-- dump date 20140618_191441 -- class Genbank::misc_feature -- table misc_feature_note -- id note 512565000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 512565000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 512565000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565000004 Walker A motif; other site 512565000005 ATP binding site [chemical binding]; other site 512565000006 Walker B motif; other site 512565000007 arginine finger; other site 512565000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 512565000009 DnaA box-binding interface [nucleotide binding]; other site 512565000010 DNA polymerase III subunit beta; Validated; Region: PRK07761 512565000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 512565000012 putative DNA binding surface [nucleotide binding]; other site 512565000013 dimer interface [polypeptide binding]; other site 512565000014 beta-clamp/clamp loader binding surface; other site 512565000015 beta-clamp/translesion DNA polymerase binding surface; other site 512565000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 512565000017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 512565000018 recombination protein F; Reviewed; Region: recF; PRK00064 512565000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 512565000020 Walker A/P-loop; other site 512565000021 ATP binding site [chemical binding]; other site 512565000022 Q-loop/lid; other site 512565000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565000024 ABC transporter signature motif; other site 512565000025 Walker B; other site 512565000026 D-loop; other site 512565000027 H-loop/switch region; other site 512565000028 Protein of unknown function (DUF721); Region: DUF721; cl02324 512565000029 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 512565000030 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 512565000031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565000032 Mg2+ binding site [ion binding]; other site 512565000033 G-X-G motif; other site 512565000034 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 512565000035 anchoring element; other site 512565000036 dimer interface [polypeptide binding]; other site 512565000037 ATP binding site [chemical binding]; other site 512565000038 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 512565000039 active site 512565000040 metal binding site [ion binding]; metal-binding site 512565000041 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 512565000042 DNA gyrase subunit A; Validated; Region: PRK05560 512565000043 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 512565000044 CAP-like domain; other site 512565000045 active site 512565000046 primary dimer interface [polypeptide binding]; other site 512565000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565000053 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 512565000054 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 512565000055 putative deacylase active site [active] 512565000056 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 512565000057 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 512565000058 catalytic residues [active] 512565000059 Fe-S metabolism associated domain; Region: SufE; cl00951 512565000060 FOG: CBS domain [General function prediction only]; Region: COG0517 512565000061 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 512565000062 prolyl-tRNA synthetase; Provisional; Region: PRK09194 512565000063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565000064 motif 1; other site 512565000065 dimer interface [polypeptide binding]; other site 512565000066 active site 512565000067 motif 2; other site 512565000068 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 512565000069 putative deacylase active site [active] 512565000070 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565000071 active site 512565000072 motif 3; other site 512565000073 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 512565000074 anticodon binding site; other site 512565000075 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 512565000076 active site 512565000077 catalytic triad [active] 512565000078 oxyanion hole [active] 512565000079 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 512565000080 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 512565000081 active site residue [active] 512565000082 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 512565000083 active site residue [active] 512565000084 HSP90 family protein; Provisional; Region: PRK14083 512565000085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565000086 ATP binding site [chemical binding]; other site 512565000087 Mg2+ binding site [ion binding]; other site 512565000088 G-X-G motif; other site 512565000089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565000090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565000091 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 512565000092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512565000093 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565000094 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 512565000095 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 512565000096 active site 512565000097 catalytic residues [active] 512565000098 metal binding site [ion binding]; metal-binding site 512565000099 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 512565000100 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 512565000101 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 512565000102 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565000103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565000104 active site 512565000105 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565000106 MarR family; Region: MarR; pfam01047 512565000107 MarR family; Region: MarR_2; cl17246 512565000108 Uncharacterized conserved protein [Function unknown]; Region: COG2353 512565000109 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565000111 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565000112 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 512565000113 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 512565000114 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 512565000115 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 512565000116 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 512565000117 phosphopeptide binding site; other site 512565000118 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 512565000119 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 512565000120 phosphopeptide binding site; other site 512565000121 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 512565000122 active site 512565000123 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 512565000124 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 512565000125 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 512565000126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 512565000127 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565000128 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565000129 active site 512565000130 ATP binding site [chemical binding]; other site 512565000131 substrate binding site [chemical binding]; other site 512565000132 activation loop (A-loop); other site 512565000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565000135 active site 512565000136 ATP binding site [chemical binding]; other site 512565000137 substrate binding site [chemical binding]; other site 512565000138 activation loop (A-loop); other site 512565000139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565000142 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 512565000143 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 512565000144 glutamine binding [chemical binding]; other site 512565000145 catalytic triad [active] 512565000146 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 512565000147 active site 512565000148 catalytic site [active] 512565000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 512565000150 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 512565000151 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 512565000152 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 512565000153 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 512565000154 4Fe-4S binding domain; Region: Fer4; pfam00037 512565000155 Cysteine-rich domain; Region: CCG; pfam02754 512565000156 Cysteine-rich domain; Region: CCG; pfam02754 512565000157 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 512565000158 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512565000159 Domain of unknown function DUF21; Region: DUF21; pfam01595 512565000160 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512565000161 Transporter associated domain; Region: CorC_HlyC; smart01091 512565000162 Domain of unknown function DUF21; Region: DUF21; pfam01595 512565000163 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512565000164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512565000165 Laminin G domain; Region: Laminin_G_2; pfam02210 512565000166 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565000167 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 512565000168 trimer interface [polypeptide binding]; other site 512565000169 active site 512565000170 YcxB-like protein; Region: YcxB; pfam14317 512565000171 YCII-related domain; Region: YCII; cl00999 512565000172 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565000173 active site 512565000174 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565000175 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 512565000176 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 512565000177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565000178 active site 512565000179 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 512565000180 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565000181 active site 512565000182 catalytic residues [active] 512565000183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565000184 catalytic core [active] 512565000185 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 512565000186 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 512565000187 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 512565000188 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 512565000189 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 512565000190 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 512565000191 putative active site [active] 512565000192 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565000193 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512565000194 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 512565000195 NHL repeat; Region: NHL; pfam01436 512565000196 Sec24-related protein; Provisional; Region: PTZ00395 512565000197 Vta1 like; Region: DUF605; pfam04652 512565000198 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 512565000199 E3 interaction surface; other site 512565000200 lipoyl attachment site [posttranslational modification]; other site 512565000201 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 512565000202 e3 binding domain; Region: E3_binding; pfam02817 512565000203 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 512565000204 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 512565000205 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 512565000206 alpha subunit interface [polypeptide binding]; other site 512565000207 TPP binding site [chemical binding]; other site 512565000208 heterodimer interface [polypeptide binding]; other site 512565000209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565000210 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 512565000211 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 512565000212 TPP-binding site [chemical binding]; other site 512565000213 tetramer interface [polypeptide binding]; other site 512565000214 heterodimer interface [polypeptide binding]; other site 512565000215 phosphorylation loop region [posttranslational modification] 512565000216 Dynamin family; Region: Dynamin_N; pfam00350 512565000217 YfjP GTPase; Region: YfjP; cd11383 512565000218 G1 box; other site 512565000219 GTP/Mg2+ binding site [chemical binding]; other site 512565000220 Switch I region; other site 512565000221 G2 box; other site 512565000222 Switch II region; other site 512565000223 G3 box; other site 512565000224 G4 box; other site 512565000225 G5 box; other site 512565000226 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565000227 G1 box; other site 512565000228 GTP/Mg2+ binding site [chemical binding]; other site 512565000229 G2 box; other site 512565000230 Switch I region; other site 512565000231 G3 box; other site 512565000232 Switch II region; other site 512565000233 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 512565000234 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 512565000235 nucleotide binding site [chemical binding]; other site 512565000236 NEF interaction site [polypeptide binding]; other site 512565000237 SBD interface [polypeptide binding]; other site 512565000238 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 512565000239 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 512565000240 dimer interface [polypeptide binding]; other site 512565000241 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 512565000242 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 512565000243 HSP70 interaction site [polypeptide binding]; other site 512565000244 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 512565000245 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 512565000246 Zn binding sites [ion binding]; other site 512565000247 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 512565000248 dimer interface [polypeptide binding]; other site 512565000249 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 512565000250 DNA binding residues [nucleotide binding] 512565000251 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565000252 putative dimer interface [polypeptide binding]; other site 512565000253 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 512565000254 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 512565000255 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 512565000256 TrkA-C domain; Region: TrkA_C; pfam02080 512565000257 sugar efflux transporter; Region: 2A0120; TIGR00899 512565000258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000259 putative substrate translocation pore; other site 512565000260 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 512565000261 Clp amino terminal domain; Region: Clp_N; pfam02861 512565000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565000263 Walker A motif; other site 512565000264 ATP binding site [chemical binding]; other site 512565000265 Walker B motif; other site 512565000266 arginine finger; other site 512565000267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565000268 Walker A motif; other site 512565000269 ATP binding site [chemical binding]; other site 512565000270 Walker B motif; other site 512565000271 arginine finger; other site 512565000272 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 512565000273 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565000274 dimerization interface [polypeptide binding]; other site 512565000275 putative DNA binding site [nucleotide binding]; other site 512565000276 putative Zn2+ binding site [ion binding]; other site 512565000277 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 512565000278 intersubunit interface [polypeptide binding]; other site 512565000279 active site 512565000280 Zn2+ binding site [ion binding]; other site 512565000281 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565000282 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 512565000283 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 512565000284 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 512565000285 active site 512565000286 metal binding site [ion binding]; metal-binding site 512565000287 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 512565000288 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 512565000289 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 512565000290 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 512565000291 active site 512565000292 intersubunit interface [polypeptide binding]; other site 512565000293 zinc binding site [ion binding]; other site 512565000294 Na+ binding site [ion binding]; other site 512565000295 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 512565000296 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 512565000297 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 512565000298 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 512565000299 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565000300 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 512565000301 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 512565000302 GDP-binding site [chemical binding]; other site 512565000303 ACT binding site; other site 512565000304 IMP binding site; other site 512565000305 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 512565000306 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 512565000307 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 512565000308 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 512565000309 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 512565000310 SCP-2 sterol transfer family; Region: SCP2; pfam02036 512565000311 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 512565000312 adenylosuccinate lyase; Region: purB; TIGR00928 512565000313 tetramer interface [polypeptide binding]; other site 512565000314 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565000315 cleavage site 512565000316 active site 512565000317 substrate binding sites [chemical binding]; other site 512565000318 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 512565000319 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 512565000320 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 512565000321 putative active site [active] 512565000322 catalytic triad [active] 512565000323 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 512565000324 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 512565000325 dimerization interface [polypeptide binding]; other site 512565000326 ATP binding site [chemical binding]; other site 512565000327 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 512565000328 dimerization interface [polypeptide binding]; other site 512565000329 ATP binding site [chemical binding]; other site 512565000330 Cytochrome C biogenesis protein; Region: CcmH; cl01179 512565000331 amidophosphoribosyltransferase; Provisional; Region: PRK07847 512565000332 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 512565000333 active site 512565000334 tetramer interface [polypeptide binding]; other site 512565000335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565000336 active site 512565000337 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 512565000338 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 512565000339 dimerization interface [polypeptide binding]; other site 512565000340 putative ATP binding site [chemical binding]; other site 512565000341 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 512565000342 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565000343 FeS/SAM binding site; other site 512565000344 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 512565000345 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 512565000346 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 512565000347 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 512565000348 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 512565000349 NAD binding site [chemical binding]; other site 512565000350 Phe binding site; other site 512565000351 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 512565000352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565000353 S-adenosylmethionine binding site [chemical binding]; other site 512565000354 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 512565000355 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 512565000356 Protease prsW family; Region: PrsW-protease; pfam13367 512565000357 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565000358 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565000359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565000360 DNA binding residues [nucleotide binding] 512565000361 rod shape-determining protein MreC; Region: MreC; pfam04085 512565000362 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 512565000363 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 512565000364 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 512565000365 CoenzymeA binding site [chemical binding]; other site 512565000366 subunit interaction site [polypeptide binding]; other site 512565000367 PHB binding site; other site 512565000368 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565000369 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565000370 DNA binding residues [nucleotide binding] 512565000371 B12 binding domain; Region: B12-binding_2; pfam02607 512565000372 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565000373 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 512565000374 nudix motif; other site 512565000375 phytoene desaturase; Region: crtI_fam; TIGR02734 512565000376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565000377 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 512565000378 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 512565000379 substrate binding pocket [chemical binding]; other site 512565000380 chain length determination region; other site 512565000381 substrate-Mg2+ binding site; other site 512565000382 catalytic residues [active] 512565000383 aspartate-rich region 1; other site 512565000384 active site lid residues [active] 512565000385 aspartate-rich region 2; other site 512565000386 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 512565000387 active site lid residues [active] 512565000388 substrate binding pocket [chemical binding]; other site 512565000389 catalytic residues [active] 512565000390 substrate-Mg2+ binding site; other site 512565000391 aspartate-rich region 1; other site 512565000392 aspartate-rich region 2; other site 512565000393 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 512565000394 DNA photolyase; Region: DNA_photolyase; pfam00875 512565000395 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 512565000396 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565000397 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565000398 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 512565000399 iron-sulfur cluster [ion binding]; other site 512565000400 [2Fe-2S] cluster binding site [ion binding]; other site 512565000401 Phytase; Region: Phytase; cl17685 512565000402 YcfA-like protein; Region: YcfA; cl00752 512565000403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565000404 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 512565000405 putative ADP-binding pocket [chemical binding]; other site 512565000406 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 512565000407 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 512565000408 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 512565000409 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 512565000410 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 512565000411 CGNR zinc finger; Region: zf-CGNR; pfam11706 512565000412 Predicted integral membrane protein [Function unknown]; Region: COG5660 512565000413 Putative zinc-finger; Region: zf-HC2; pfam13490 512565000414 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 512565000415 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 512565000416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565000417 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565000418 anti sigma factor interaction site; other site 512565000419 regulatory phosphorylation site [posttranslational modification]; other site 512565000420 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 512565000421 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 512565000422 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 512565000423 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 512565000424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565000425 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565000426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565000427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565000428 dimer interface [polypeptide binding]; other site 512565000429 phosphorylation site [posttranslational modification] 512565000430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565000431 ATP binding site [chemical binding]; other site 512565000432 Mg2+ binding site [ion binding]; other site 512565000433 G-X-G motif; other site 512565000434 Response regulator receiver domain; Region: Response_reg; pfam00072 512565000435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565000436 active site 512565000437 phosphorylation site [posttranslational modification] 512565000438 intermolecular recognition site; other site 512565000439 dimerization interface [polypeptide binding]; other site 512565000440 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 512565000441 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565000442 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565000443 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565000444 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565000445 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565000446 Walker A/P-loop; other site 512565000447 ATP binding site [chemical binding]; other site 512565000448 Q-loop/lid; other site 512565000449 ABC transporter signature motif; other site 512565000450 Walker B; other site 512565000451 D-loop; other site 512565000452 H-loop/switch region; other site 512565000453 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 512565000454 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565000455 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565000456 FAD binding domain; Region: FAD_binding_4; pfam01565 512565000457 RibD C-terminal domain; Region: RibD_C; cl17279 512565000458 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512565000459 RibD C-terminal domain; Region: RibD_C; cl17279 512565000460 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565000461 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565000462 GAF domain; Region: GAF_3; pfam13492 512565000463 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 512565000464 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565000465 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565000466 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000467 dimerization interface [polypeptide binding]; other site 512565000468 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565000469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000470 dimerization interface [polypeptide binding]; other site 512565000471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000472 dimerization interface [polypeptide binding]; other site 512565000473 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565000474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000475 dimerization interface [polypeptide binding]; other site 512565000476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000477 dimerization interface [polypeptide binding]; other site 512565000478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000479 dimerization interface [polypeptide binding]; other site 512565000480 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565000481 dimerization interface [polypeptide binding]; other site 512565000482 GAF domain; Region: GAF_2; pfam13185 512565000483 GAF domain; Region: GAF; pfam01590 512565000484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565000485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565000486 ATP binding site [chemical binding]; other site 512565000487 Mg2+ binding site [ion binding]; other site 512565000488 G-X-G motif; other site 512565000489 Response regulator receiver domain; Region: Response_reg; pfam00072 512565000490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565000491 active site 512565000492 phosphorylation site [posttranslational modification] 512565000493 intermolecular recognition site; other site 512565000494 dimerization interface [polypeptide binding]; other site 512565000495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565000496 Response regulator receiver domain; Region: Response_reg; pfam00072 512565000497 active site 512565000498 phosphorylation site [posttranslational modification] 512565000499 intermolecular recognition site; other site 512565000500 dimerization interface [polypeptide binding]; other site 512565000501 Pectate lyase; Region: Pectate_lyase; pfam03211 512565000502 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565000503 anti sigma factor interaction site; other site 512565000504 regulatory phosphorylation site [posttranslational modification]; other site 512565000505 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 512565000506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565000507 inhibitor-cofactor binding pocket; inhibition site 512565000508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565000509 catalytic residue [active] 512565000510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565000511 catalytic core [active] 512565000512 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 512565000513 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512565000514 catalytic residues [active] 512565000515 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 512565000516 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 512565000517 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 512565000518 ResB-like family; Region: ResB; pfam05140 512565000519 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 512565000520 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 512565000521 prenyltransferase; Reviewed; Region: ubiA; PRK12888 512565000522 UbiA prenyltransferase family; Region: UbiA; pfam01040 512565000523 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565000524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565000525 DNA binding residues [nucleotide binding] 512565000526 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 512565000527 Flavoprotein; Region: Flavoprotein; pfam02441 512565000528 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 512565000529 DNA binding residues [nucleotide binding] 512565000530 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565000531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565000532 putative DNA binding site [nucleotide binding]; other site 512565000533 putative Zn2+ binding site [ion binding]; other site 512565000534 AsnC family; Region: AsnC_trans_reg; pfam01037 512565000535 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 512565000536 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 512565000537 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512565000538 ATP binding site [chemical binding]; other site 512565000539 Mg++ binding site [ion binding]; other site 512565000540 motif III; other site 512565000541 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565000542 nucleotide binding region [chemical binding]; other site 512565000543 ATP-binding site [chemical binding]; other site 512565000544 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 512565000545 NlpC/P60 family; Region: NLPC_P60; pfam00877 512565000546 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 512565000547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565000548 FeS/SAM binding site; other site 512565000549 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 512565000550 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 512565000551 putative binding site residues; other site 512565000552 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565000553 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565000554 dimer interface [polypeptide binding]; other site 512565000555 putative PBP binding regions; other site 512565000556 ABC-ATPase subunit interface; other site 512565000557 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565000558 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565000559 Walker A/P-loop; other site 512565000560 ATP binding site [chemical binding]; other site 512565000561 Q-loop/lid; other site 512565000562 ABC transporter signature motif; other site 512565000563 Walker B; other site 512565000564 D-loop; other site 512565000565 H-loop/switch region; other site 512565000566 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 512565000567 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 512565000568 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 512565000569 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565000570 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 512565000571 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565000572 Part of AAA domain; Region: AAA_19; pfam13245 512565000573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565000574 putative DNA binding site [nucleotide binding]; other site 512565000575 dimerization interface [polypeptide binding]; other site 512565000576 putative Zn2+ binding site [ion binding]; other site 512565000577 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565000578 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 512565000579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565000580 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565000581 active site 512565000582 catalytic tetrad [active] 512565000583 Uncharacterized conserved protein [Function unknown]; Region: COG4279 512565000584 SWIM zinc finger; Region: SWIM; pfam04434 512565000585 SNF2 Helicase protein; Region: DUF3670; pfam12419 512565000586 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 512565000587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565000588 ATP binding site [chemical binding]; other site 512565000589 putative Mg++ binding site [ion binding]; other site 512565000590 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 512565000591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565000592 nucleotide binding region [chemical binding]; other site 512565000593 ATP-binding site [chemical binding]; other site 512565000594 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 512565000595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565000596 FeS/SAM binding site; other site 512565000597 seryl-tRNA synthetase; Provisional; Region: PRK05431 512565000598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565000599 DNA-binding site [nucleotide binding]; DNA binding site 512565000600 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565000601 Helix-turn-helix domain; Region: HTH_17; cl17695 512565000602 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 512565000603 Domain of unknown function DUF87; Region: DUF87; pfam01935 512565000604 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 512565000605 catalytic triad [active] 512565000606 conserved cis-peptide bond; other site 512565000607 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565000608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565000609 non-specific DNA binding site [nucleotide binding]; other site 512565000610 salt bridge; other site 512565000611 sequence-specific DNA binding site [nucleotide binding]; other site 512565000612 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 512565000613 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 512565000614 IPT/TIG domain; Region: TIG; pfam01833 512565000615 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 512565000616 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 512565000617 Phage terminase large subunit; Region: Terminase_3; cl12054 512565000618 Terminase-like family; Region: Terminase_6; pfam03237 512565000619 Helix-turn-helix domain; Region: HTH_38; pfam13936 512565000620 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565000621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565000622 non-specific DNA binding site [nucleotide binding]; other site 512565000623 salt bridge; other site 512565000624 sequence-specific DNA binding site [nucleotide binding]; other site 512565000625 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512565000626 Family description; Region: UvrD_C_2; pfam13538 512565000627 AAA domain; Region: AAA_24; pfam13479 512565000628 Helix-turn-helix domain; Region: HTH_17; cl17695 512565000629 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 512565000630 sequence-specific DNA binding site [nucleotide binding]; other site 512565000631 salt bridge; other site 512565000632 conjugal transfer protein TrbA; Provisional; Region: PRK13890 512565000633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565000634 sequence-specific DNA binding site [nucleotide binding]; other site 512565000635 salt bridge; other site 512565000636 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 512565000637 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 512565000638 Int/Topo IB signature motif; other site 512565000639 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 512565000640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565000641 S-adenosylmethionine binding site [chemical binding]; other site 512565000642 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 512565000643 NADH dehydrogenase subunit A; Validated; Region: PRK07928 512565000644 NADH dehydrogenase subunit B; Validated; Region: PRK06411 512565000645 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 512565000646 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 512565000647 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 512565000648 NADH dehydrogenase subunit D; Validated; Region: PRK06075 512565000649 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 512565000650 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 512565000651 putative dimer interface [polypeptide binding]; other site 512565000652 [2Fe-2S] cluster binding site [ion binding]; other site 512565000653 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 512565000654 SLBB domain; Region: SLBB; pfam10531 512565000655 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 512565000656 NADH dehydrogenase subunit G; Validated; Region: PRK07860 512565000657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565000658 catalytic loop [active] 512565000659 iron binding site [ion binding]; other site 512565000660 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 512565000661 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565000662 molybdopterin cofactor binding site; other site 512565000663 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 512565000664 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 512565000665 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 512565000666 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 512565000667 4Fe-4S binding domain; Region: Fer4; pfam00037 512565000668 4Fe-4S binding domain; Region: Fer4; pfam00037 512565000669 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 512565000670 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 512565000671 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 512565000672 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 512565000673 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 512565000674 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 512565000675 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 512565000676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 512565000677 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 512565000678 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 512565000679 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 512565000680 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 512565000681 substrate binding pocket [chemical binding]; other site 512565000682 chain length determination region; other site 512565000683 substrate-Mg2+ binding site; other site 512565000684 catalytic residues [active] 512565000685 aspartate-rich region 1; other site 512565000686 active site lid residues [active] 512565000687 aspartate-rich region 2; other site 512565000688 putative transporter; Provisional; Region: PRK12382 512565000689 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565000690 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 512565000691 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565000692 Putative zinc-finger; Region: zf-HC2; pfam13490 512565000693 Predicted permeases [General function prediction only]; Region: RarD; COG2962 512565000694 Predicted membrane protein [Function unknown]; Region: COG1950 512565000695 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 512565000696 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 512565000697 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 512565000698 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565000699 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565000700 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565000701 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 512565000702 active site 512565000703 catalytic residues [active] 512565000704 acetyl-CoA synthetase; Provisional; Region: PRK00174 512565000705 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 512565000706 active site 512565000707 CoA binding site [chemical binding]; other site 512565000708 acyl-activating enzyme (AAE) consensus motif; other site 512565000709 AMP binding site [chemical binding]; other site 512565000710 acetate binding site [chemical binding]; other site 512565000711 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 512565000712 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565000713 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565000714 anti sigma factor interaction site; other site 512565000715 regulatory phosphorylation site [posttranslational modification]; other site 512565000716 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 512565000717 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565000718 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 512565000719 ATP binding site [chemical binding]; other site 512565000720 Walker B motif; other site 512565000721 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 512565000722 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 512565000723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565000724 ATP binding site [chemical binding]; other site 512565000725 putative Mg++ binding site [ion binding]; other site 512565000726 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 512565000727 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565000728 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565000729 anti sigma factor interaction site; other site 512565000730 regulatory phosphorylation site [posttranslational modification]; other site 512565000731 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565000732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565000733 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 512565000734 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 512565000735 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 512565000736 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 512565000737 active site 512565000738 interdomain interaction site; other site 512565000739 putative metal-binding site [ion binding]; other site 512565000740 nucleotide binding site [chemical binding]; other site 512565000741 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 512565000742 domain I; other site 512565000743 phosphate binding site [ion binding]; other site 512565000744 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 512565000745 domain II; other site 512565000746 domain III; other site 512565000747 nucleotide binding site [chemical binding]; other site 512565000748 DNA binding groove [nucleotide binding] 512565000749 catalytic site [active] 512565000750 domain IV; other site 512565000751 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 512565000752 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 512565000753 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 512565000754 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 512565000755 FAD binding domain; Region: FAD_binding_4; pfam01565 512565000756 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 512565000757 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565000758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565000759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 512565000760 dimer interface [polypeptide binding]; other site 512565000761 active site 512565000762 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565000763 substrate binding site [chemical binding]; other site 512565000764 catalytic residue [active] 512565000765 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565000766 thymidylate kinase; Validated; Region: tmk; PRK00698 512565000767 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 512565000768 TMP-binding site; other site 512565000769 ATP-binding site [chemical binding]; other site 512565000770 DNA polymerase III subunit delta'; Validated; Region: PRK07940 512565000771 DNA polymerase III subunit delta'; Validated; Region: PRK08485 512565000772 PSP1 C-terminal conserved region; Region: PSP1; cl00770 512565000773 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565000774 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565000775 DNA binding site [nucleotide binding] 512565000776 active site 512565000777 Int/Topo IB signature motif; other site 512565000778 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 512565000779 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 512565000780 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 512565000781 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565000782 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565000783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565000784 sequence-specific DNA binding site [nucleotide binding]; other site 512565000785 salt bridge; other site 512565000786 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 512565000787 intracellular protease, PfpI family; Region: PfpI; TIGR01382 512565000788 proposed catalytic triad [active] 512565000789 conserved cys residue [active] 512565000790 enterobactin exporter EntS; Provisional; Region: PRK10489 512565000791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000792 putative substrate translocation pore; other site 512565000793 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565000794 nudix motif; other site 512565000795 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 512565000796 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 512565000797 putative DNA binding site [nucleotide binding]; other site 512565000798 putative homodimer interface [polypeptide binding]; other site 512565000799 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 512565000800 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 512565000801 active site 512565000802 DNA binding site [nucleotide binding] 512565000803 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 512565000804 DNA binding site [nucleotide binding] 512565000805 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 512565000806 nucleotide binding site [chemical binding]; other site 512565000807 PA14 domain; Region: PA14; cl08459 512565000808 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 512565000809 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 512565000810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565000811 catalytic residue [active] 512565000812 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 512565000813 substrate binding site [chemical binding]; other site 512565000814 active site 512565000815 catalytic residues [active] 512565000816 heterodimer interface [polypeptide binding]; other site 512565000817 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565000818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565000819 DNA-binding site [nucleotide binding]; DNA binding site 512565000820 UTRA domain; Region: UTRA; pfam07702 512565000821 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 512565000822 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 512565000823 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 512565000824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565000825 ATP binding site [chemical binding]; other site 512565000826 putative Mg++ binding site [ion binding]; other site 512565000827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565000828 nucleotide binding region [chemical binding]; other site 512565000829 ATP-binding site [chemical binding]; other site 512565000830 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 512565000831 WYL domain; Region: WYL; pfam13280 512565000832 ferredoxin--NADP(+) reductase; Provisional; Region: PLN03115 512565000833 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 512565000834 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 512565000835 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 512565000836 DNA-binding site [nucleotide binding]; DNA binding site 512565000837 RNA-binding motif; other site 512565000838 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 512565000839 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565000840 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000842 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 512565000843 beta-galactosidase; Region: BGL; TIGR03356 512565000844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565000845 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565000846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000847 hypothetical protein; Provisional; Region: PRK08236 512565000848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565000849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000850 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 512565000851 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 512565000852 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565000853 MarR family; Region: MarR; pfam01047 512565000854 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565000855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000856 putative substrate translocation pore; other site 512565000857 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 512565000858 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 512565000859 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 512565000860 phosphoserine aminotransferase; Provisional; Region: PRK03080 512565000861 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565000862 catalytic residue [active] 512565000863 citrate synthase 2; Provisional; Region: PRK12350 512565000864 Citrate synthase; Region: Citrate_synt; pfam00285 512565000865 oxalacetate binding site [chemical binding]; other site 512565000866 citrylCoA binding site [chemical binding]; other site 512565000867 coenzyme A binding site [chemical binding]; other site 512565000868 catalytic triad [active] 512565000869 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 512565000870 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 512565000871 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 512565000872 enterobactin exporter EntS; Provisional; Region: PRK10489 512565000873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000874 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 512565000875 active site 512565000876 catalytic residues [active] 512565000877 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 512565000878 putative FMN binding site [chemical binding]; other site 512565000879 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 512565000880 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 512565000881 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 512565000882 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 512565000883 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 512565000884 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 512565000885 Walker A/P-loop; other site 512565000886 ATP binding site [chemical binding]; other site 512565000887 Q-loop/lid; other site 512565000888 ABC transporter signature motif; other site 512565000889 Walker B; other site 512565000890 D-loop; other site 512565000891 H-loop/switch region; other site 512565000892 TOBE domain; Region: TOBE_2; pfam08402 512565000893 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565000894 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565000895 ATP binding site [chemical binding]; other site 512565000896 Mg2+ binding site [ion binding]; other site 512565000897 G-X-G motif; other site 512565000898 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 512565000899 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 512565000900 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 512565000901 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 512565000902 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 512565000903 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 512565000904 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 512565000905 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512565000906 Walker A/P-loop; other site 512565000907 ATP binding site [chemical binding]; other site 512565000908 Q-loop/lid; other site 512565000909 ABC transporter signature motif; other site 512565000910 Walker B; other site 512565000911 D-loop; other site 512565000912 H-loop/switch region; other site 512565000913 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 512565000914 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565000915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565000916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565000917 Amidinotransferase; Region: Amidinotransf; cl12043 512565000918 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 512565000919 Domain of unknown function (DUF239); Region: DUF239; pfam03080 512565000920 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 512565000921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565000922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565000923 DNA binding residues [nucleotide binding] 512565000924 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565000925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565000926 putative substrate translocation pore; other site 512565000927 Response regulator receiver domain; Region: Response_reg; pfam00072 512565000928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565000929 active site 512565000930 phosphorylation site [posttranslational modification] 512565000931 intermolecular recognition site; other site 512565000932 dimerization interface [polypeptide binding]; other site 512565000933 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 512565000934 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565000935 NAD(P) binding site [chemical binding]; other site 512565000936 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 512565000937 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 512565000938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512565000939 active site 512565000940 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565000941 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 512565000942 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 512565000943 inhibitor-cofactor binding pocket; inhibition site 512565000944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565000945 catalytic residue [active] 512565000946 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 512565000947 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 512565000948 NAD(P) binding site [chemical binding]; other site 512565000949 homodimer interface [polypeptide binding]; other site 512565000950 substrate binding site [chemical binding]; other site 512565000951 active site 512565000952 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 512565000953 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565000954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565000955 NAD(P) binding site [chemical binding]; other site 512565000956 active site 512565000957 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 512565000958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565000959 acyl-activating enzyme (AAE) consensus motif; other site 512565000960 AMP binding site [chemical binding]; other site 512565000961 active site 512565000962 CoA binding site [chemical binding]; other site 512565000963 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 512565000964 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565000965 NAD(P) binding site [chemical binding]; other site 512565000966 catalytic residues [active] 512565000967 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565000968 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 512565000969 Putative sensor; Region: Sensor; pfam13796 512565000970 Histidine kinase; Region: HisKA_3; pfam07730 512565000971 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565000972 Mg2+ binding site [ion binding]; other site 512565000973 G-X-G motif; other site 512565000974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565000975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565000976 active site 512565000977 phosphorylation site [posttranslational modification] 512565000978 intermolecular recognition site; other site 512565000979 dimerization interface [polypeptide binding]; other site 512565000980 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565000981 DNA binding residues [nucleotide binding] 512565000982 MMPL family; Region: MMPL; pfam03176 512565000983 MMPL family; Region: MMPL; pfam03176 512565000984 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 512565000985 CrcB-like protein; Region: CRCB; cl09114 512565000986 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 512565000987 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 512565000988 Asp-box motif; other site 512565000989 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565000990 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565000991 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 512565000992 protein-splicing catalytic site; other site 512565000993 thioester formation/cholesterol transfer; other site 512565000994 Pretoxin HINT domain; Region: PT-HINT; pfam07591 512565000995 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 512565000996 pseudaminic acid synthase; Region: PseI; TIGR03586 512565000997 NeuB family; Region: NeuB; pfam03102 512565000998 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 512565000999 NeuB binding interface [polypeptide binding]; other site 512565001000 putative substrate binding site [chemical binding]; other site 512565001001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565001002 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565001003 active site 512565001004 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565001005 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565001006 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565001007 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565001008 metal binding site [ion binding]; metal-binding site 512565001009 active site 512565001010 I-site; other site 512565001011 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565001012 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565001013 TAP-like protein; Region: Abhydrolase_4; pfam08386 512565001014 Predicted membrane protein [Function unknown]; Region: COG2119 512565001015 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 512565001016 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 512565001017 TPR repeat; Region: TPR_11; pfam13414 512565001018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565001019 binding surface 512565001020 TPR motif; other site 512565001021 TPR repeat; Region: TPR_11; pfam13414 512565001022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565001023 binding surface 512565001024 TPR motif; other site 512565001025 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 512565001026 homotrimer interaction site [polypeptide binding]; other site 512565001027 putative active site [active] 512565001028 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565001029 Glyco_18 domain; Region: Glyco_18; smart00636 512565001030 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 512565001031 active site 512565001032 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 512565001033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565001034 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 512565001035 NAD(P) binding site [chemical binding]; other site 512565001036 active site 512565001037 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565001038 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 512565001039 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 512565001040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565001041 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565001042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565001043 DNA binding residues [nucleotide binding] 512565001044 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565001045 serine hydroxymethyltransferase; Provisional; Region: PRK13580 512565001046 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 512565001047 dimer interface [polypeptide binding]; other site 512565001048 active site 512565001049 glycine-pyridoxal phosphate binding site [chemical binding]; other site 512565001050 folate binding site [chemical binding]; other site 512565001051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565001052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565001053 DNA binding site [nucleotide binding] 512565001054 domain linker motif; other site 512565001055 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565001056 dimerization interface [polypeptide binding]; other site 512565001057 ligand binding site [chemical binding]; other site 512565001058 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 512565001059 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 512565001060 ligand binding site [chemical binding]; other site 512565001061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565001062 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565001063 TM-ABC transporter signature motif; other site 512565001064 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565001065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565001066 Walker A/P-loop; other site 512565001067 ATP binding site [chemical binding]; other site 512565001068 Q-loop/lid; other site 512565001069 ABC transporter signature motif; other site 512565001070 Walker B; other site 512565001071 D-loop; other site 512565001072 H-loop/switch region; other site 512565001073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565001074 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565001075 NAD(P) binding site [chemical binding]; other site 512565001076 active site 512565001077 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565001078 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565001079 metal binding site [ion binding]; metal-binding site 512565001080 active site 512565001081 I-site; other site 512565001082 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565001083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565001084 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512565001085 substrate binding pocket [chemical binding]; other site 512565001086 membrane-bound complex binding site; other site 512565001087 hinge residues; other site 512565001088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565001089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565001090 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565001091 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565001092 Walker A/P-loop; other site 512565001093 ATP binding site [chemical binding]; other site 512565001094 Q-loop/lid; other site 512565001095 ABC transporter signature motif; other site 512565001096 Walker B; other site 512565001097 D-loop; other site 512565001098 H-loop/switch region; other site 512565001099 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 512565001100 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 512565001101 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 512565001102 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 512565001103 Adenosylhomocysteinase; Provisional; Region: PTZ00075 512565001104 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 512565001105 homotetramer interface [polypeptide binding]; other site 512565001106 ligand binding site [chemical binding]; other site 512565001107 catalytic site [active] 512565001108 NAD binding site [chemical binding]; other site 512565001109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565001110 DNA binding site [nucleotide binding] 512565001111 domain linker motif; other site 512565001112 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565001113 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 512565001114 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 512565001115 putative metal binding site [ion binding]; other site 512565001116 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 512565001117 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512565001118 active site 512565001119 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 512565001120 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 512565001121 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565001123 NAD(P) binding site [chemical binding]; other site 512565001124 active site 512565001125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565001126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565001127 dimerization interface [polypeptide binding]; other site 512565001128 DNA binding residues [nucleotide binding] 512565001129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565001130 putative substrate translocation pore; other site 512565001131 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 512565001132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565001133 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565001134 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565001135 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512565001136 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 512565001137 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 512565001138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565001139 FeS/SAM binding site; other site 512565001140 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 512565001141 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 512565001142 active site 512565001143 catalytic site [active] 512565001144 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 512565001145 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 512565001146 Ca binding site [ion binding]; other site 512565001147 substrate binding site [chemical binding]; other site 512565001148 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565001149 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 512565001150 DNA binding residues [nucleotide binding] 512565001151 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 512565001152 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 512565001153 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 512565001154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565001155 Uncharacterized conserved protein [Function unknown]; Region: COG3268 512565001156 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 512565001157 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512565001158 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 512565001159 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565001160 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565001161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565001162 dimerization interface [polypeptide binding]; other site 512565001163 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 512565001164 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 512565001165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565001166 MASE1; Region: MASE1; cl17823 512565001167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 512565001168 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565001169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565001170 dimer interface [polypeptide binding]; other site 512565001171 phosphorylation site [posttranslational modification] 512565001172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565001173 ATP binding site [chemical binding]; other site 512565001174 Mg2+ binding site [ion binding]; other site 512565001175 G-X-G motif; other site 512565001176 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 512565001177 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 512565001178 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 512565001179 intersubunit interface [polypeptide binding]; other site 512565001180 active site 512565001181 catalytic residue [active] 512565001182 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565001183 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565001184 DNA-binding site [nucleotide binding]; DNA binding site 512565001185 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 512565001186 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 512565001187 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 512565001188 generic binding surface I; other site 512565001189 generic binding surface II; other site 512565001190 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 512565001191 putative active site [active] 512565001192 putative catalytic site [active] 512565001193 putative Mg binding site IVb [ion binding]; other site 512565001194 putative phosphate binding site [ion binding]; other site 512565001195 putative DNA binding site [nucleotide binding]; other site 512565001196 putative Mg binding site IVa [ion binding]; other site 512565001197 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 512565001198 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 512565001199 putative active site [active] 512565001200 putative metal binding site [ion binding]; other site 512565001201 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 512565001202 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 512565001203 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 512565001204 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 512565001205 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 512565001206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565001207 HAMP domain; Region: HAMP; pfam00672 512565001208 dimerization interface [polypeptide binding]; other site 512565001209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565001210 dimer interface [polypeptide binding]; other site 512565001211 phosphorylation site [posttranslational modification] 512565001212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565001213 ATP binding site [chemical binding]; other site 512565001214 Mg2+ binding site [ion binding]; other site 512565001215 G-X-G motif; other site 512565001216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565001217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565001218 active site 512565001219 phosphorylation site [posttranslational modification] 512565001220 intermolecular recognition site; other site 512565001221 dimerization interface [polypeptide binding]; other site 512565001222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565001223 DNA binding site [nucleotide binding] 512565001224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565001225 binding surface 512565001226 TPR motif; other site 512565001227 Smr domain; Region: Smr; pfam01713 512565001228 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 512565001229 Peptidase family M28; Region: Peptidase_M28; pfam04389 512565001230 metal binding site [ion binding]; metal-binding site 512565001231 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565001232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565001233 active site 512565001234 phosphorylation site [posttranslational modification] 512565001235 intermolecular recognition site; other site 512565001236 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565001237 CHASE3 domain; Region: CHASE3; pfam05227 512565001238 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 512565001239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565001240 dimer interface [polypeptide binding]; other site 512565001241 phosphorylation site [posttranslational modification] 512565001242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565001243 ATP binding site [chemical binding]; other site 512565001244 Mg2+ binding site [ion binding]; other site 512565001245 G-X-G motif; other site 512565001246 Response regulator receiver domain; Region: Response_reg; pfam00072 512565001247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565001248 active site 512565001249 phosphorylation site [posttranslational modification] 512565001250 intermolecular recognition site; other site 512565001251 dimerization interface [polypeptide binding]; other site 512565001252 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512565001253 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 512565001254 active site 512565001255 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565001256 classical (c) SDRs; Region: SDR_c; cd05233 512565001257 NAD(P) binding site [chemical binding]; other site 512565001258 active site 512565001259 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 512565001260 catalytic motif [active] 512565001261 Zn binding site [ion binding]; other site 512565001262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512565001263 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565001264 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565001265 active site 512565001266 ATP binding site [chemical binding]; other site 512565001267 substrate binding site [chemical binding]; other site 512565001268 activation loop (A-loop); other site 512565001269 Cellulose binding domain; Region: CBM_2; cl17741 512565001270 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 512565001271 classical (c) SDRs; Region: SDR_c; cd05233 512565001272 NAD(P) binding site [chemical binding]; other site 512565001273 active site 512565001274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565001275 sequence-specific DNA binding site [nucleotide binding]; other site 512565001276 salt bridge; other site 512565001277 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 512565001278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565001279 ATP binding site [chemical binding]; other site 512565001280 putative Mg++ binding site [ion binding]; other site 512565001281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565001282 nucleotide binding region [chemical binding]; other site 512565001283 ATP-binding site [chemical binding]; other site 512565001284 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565001285 Coenzyme A binding pocket [chemical binding]; other site 512565001286 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 512565001287 metal-binding site [ion binding] 512565001288 Methyltransferase domain; Region: Methyltransf_32; pfam13679 512565001289 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512565001290 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 512565001291 heme binding pocket [chemical binding]; other site 512565001292 heme ligand [chemical binding]; other site 512565001293 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 512565001294 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512565001295 ATP binding site [chemical binding]; other site 512565001296 Mg++ binding site [ion binding]; other site 512565001297 motif III; other site 512565001298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565001299 nucleotide binding region [chemical binding]; other site 512565001300 ATP-binding site [chemical binding]; other site 512565001301 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 512565001302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565001303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565001304 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565001305 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 512565001306 catalytic site [active] 512565001307 TAP-like protein; Region: Abhydrolase_4; pfam08386 512565001308 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 512565001309 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 512565001310 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 512565001311 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 512565001312 ATP binding site [chemical binding]; other site 512565001313 substrate interface [chemical binding]; other site 512565001314 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 512565001315 active site residue [active] 512565001316 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 512565001317 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 512565001318 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 512565001319 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 512565001320 putative catalytic cysteine [active] 512565001321 gamma-glutamyl kinase; Provisional; Region: PRK05429 512565001322 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 512565001323 nucleotide binding site [chemical binding]; other site 512565001324 homotetrameric interface [polypeptide binding]; other site 512565001325 putative phosphate binding site [ion binding]; other site 512565001326 putative allosteric binding site; other site 512565001327 PUA domain; Region: PUA; pfam01472 512565001328 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 512565001329 DNA binding site [nucleotide binding] 512565001330 active site 512565001331 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 512565001332 Leucine carboxyl methyltransferase; Region: LCM; cl01306 512565001333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565001334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565001335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565001336 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565001337 NAD(P) binding site [chemical binding]; other site 512565001338 active site 512565001339 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 512565001340 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 512565001341 MFS/sugar transport protein; Region: MFS_2; pfam13347 512565001342 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 512565001343 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 512565001344 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565001345 catalytic residue [active] 512565001346 Fic family protein [Function unknown]; Region: COG3177 512565001347 Fic/DOC family; Region: Fic; pfam02661 512565001348 NADH dehydrogenase subunit B; Validated; Region: PRK06411 512565001349 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 512565001350 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 512565001351 domain interfaces; other site 512565001352 active site 512565001353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 512565001354 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 512565001355 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565001356 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565001357 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565001358 DNA binding residues [nucleotide binding] 512565001359 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 512565001360 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 512565001361 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 512565001362 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 512565001363 4Fe-4S binding domain; Region: Fer4; pfam00037 512565001364 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 512565001365 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 512565001366 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 512565001367 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 512565001368 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 512565001369 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 512565001370 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 512565001371 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 512565001372 heat shock protein HtpX; Provisional; Region: PRK03072 512565001373 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 512565001374 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565001375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 512565001376 MOSC domain; Region: MOSC; pfam03473 512565001377 3-alpha domain; Region: 3-alpha; pfam03475 512565001378 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565001379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565001380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565001381 DNA binding residues [nucleotide binding] 512565001382 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 512565001383 putative RNAase interaction site [polypeptide binding]; other site 512565001384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 512565001385 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 512565001386 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 512565001387 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 512565001388 active site residue [active] 512565001389 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 512565001390 active site residue [active] 512565001391 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565001392 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565001393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565001394 metal binding site [ion binding]; metal-binding site 512565001395 active site 512565001396 I-site; other site 512565001397 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565001398 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 512565001399 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 512565001400 active site 512565001401 catalytic site [active] 512565001402 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565001403 active site 2 [active] 512565001404 active site 1 [active] 512565001405 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 512565001406 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 512565001407 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 512565001408 putative homodimer interface [polypeptide binding]; other site 512565001409 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 512565001410 heterodimer interface [polypeptide binding]; other site 512565001411 homodimer interface [polypeptide binding]; other site 512565001412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 512565001413 mRNA/rRNA interface [nucleotide binding]; other site 512565001414 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 512565001415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565001416 Walker A/P-loop; other site 512565001417 ATP binding site [chemical binding]; other site 512565001418 Q-loop/lid; other site 512565001419 ABC transporter signature motif; other site 512565001420 Walker B; other site 512565001421 D-loop; other site 512565001422 H-loop/switch region; other site 512565001423 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 512565001424 23S rRNA interface [nucleotide binding]; other site 512565001425 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 512565001426 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 512565001427 core dimer interface [polypeptide binding]; other site 512565001428 peripheral dimer interface [polypeptide binding]; other site 512565001429 L10 interface [polypeptide binding]; other site 512565001430 L11 interface [polypeptide binding]; other site 512565001431 putative EF-Tu interaction site [polypeptide binding]; other site 512565001432 putative EF-G interaction site [polypeptide binding]; other site 512565001433 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 512565001434 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 512565001435 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 512565001436 RPB1 interaction site [polypeptide binding]; other site 512565001437 RPB10 interaction site [polypeptide binding]; other site 512565001438 RPB11 interaction site [polypeptide binding]; other site 512565001439 RPB3 interaction site [polypeptide binding]; other site 512565001440 RPB12 interaction site [polypeptide binding]; other site 512565001441 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 512565001442 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 512565001443 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 512565001444 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 512565001445 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 512565001446 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 512565001447 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 512565001448 G-loop; other site 512565001449 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 512565001450 DNA binding site [nucleotide binding] 512565001451 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 512565001452 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 512565001453 S17 interaction site [polypeptide binding]; other site 512565001454 S8 interaction site; other site 512565001455 16S rRNA interaction site [nucleotide binding]; other site 512565001456 streptomycin interaction site [chemical binding]; other site 512565001457 23S rRNA interaction site [nucleotide binding]; other site 512565001458 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 512565001459 30S ribosomal protein S7; Validated; Region: PRK05302 512565001460 elongation factor G; Reviewed; Region: PRK00007 512565001461 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 512565001462 G1 box; other site 512565001463 putative GEF interaction site [polypeptide binding]; other site 512565001464 GTP/Mg2+ binding site [chemical binding]; other site 512565001465 Switch I region; other site 512565001466 G2 box; other site 512565001467 G3 box; other site 512565001468 Switch II region; other site 512565001469 G4 box; other site 512565001470 G5 box; other site 512565001471 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 512565001472 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 512565001473 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 512565001474 elongation factor Tu; Reviewed; Region: PRK00049 512565001475 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 512565001476 G1 box; other site 512565001477 GEF interaction site [polypeptide binding]; other site 512565001478 GTP/Mg2+ binding site [chemical binding]; other site 512565001479 Switch I region; other site 512565001480 G2 box; other site 512565001481 G3 box; other site 512565001482 Switch II region; other site 512565001483 G4 box; other site 512565001484 G5 box; other site 512565001485 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 512565001486 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 512565001487 Antibiotic Binding Site [chemical binding]; other site 512565001488 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 512565001489 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 512565001490 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 512565001491 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 512565001492 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 512565001493 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 512565001494 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 512565001495 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 512565001496 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 512565001497 putative translocon binding site; other site 512565001498 protein-rRNA interface [nucleotide binding]; other site 512565001499 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 512565001500 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 512565001501 G-X-X-G motif; other site 512565001502 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 512565001503 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 512565001504 23S rRNA interface [nucleotide binding]; other site 512565001505 5S rRNA interface [nucleotide binding]; other site 512565001506 putative antibiotic binding site [chemical binding]; other site 512565001507 L25 interface [polypeptide binding]; other site 512565001508 L27 interface [polypeptide binding]; other site 512565001509 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 512565001510 putative translocon interaction site; other site 512565001511 signal recognition particle (SRP54) interaction site; other site 512565001512 L23 interface [polypeptide binding]; other site 512565001513 trigger factor interaction site; other site 512565001514 23S rRNA interface [nucleotide binding]; other site 512565001515 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 512565001516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 512565001517 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 512565001518 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 512565001519 RNA binding site [nucleotide binding]; other site 512565001520 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 512565001521 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 512565001522 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 512565001523 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 512565001524 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 512565001525 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 512565001526 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 512565001527 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 512565001528 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 512565001529 5S rRNA interface [nucleotide binding]; other site 512565001530 L27 interface [polypeptide binding]; other site 512565001531 23S rRNA interface [nucleotide binding]; other site 512565001532 L5 interface [polypeptide binding]; other site 512565001533 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 512565001534 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 512565001535 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 512565001536 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 512565001537 23S rRNA binding site [nucleotide binding]; other site 512565001538 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 512565001539 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 512565001540 SecY translocase; Region: SecY; pfam00344 512565001541 adenylate kinase; Reviewed; Region: adk; PRK00279 512565001542 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 512565001543 AMP-binding site [chemical binding]; other site 512565001544 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 512565001545 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 512565001546 active site 512565001547 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 512565001548 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 512565001549 rRNA binding site [nucleotide binding]; other site 512565001550 predicted 30S ribosome binding site; other site 512565001551 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 512565001552 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 512565001553 30S ribosomal protein S13; Region: bact_S13; TIGR03631 512565001554 30S ribosomal protein S11; Validated; Region: PRK05309 512565001555 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 512565001556 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 512565001557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512565001558 RNA binding surface [nucleotide binding]; other site 512565001559 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 512565001560 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 512565001561 alphaNTD homodimer interface [polypeptide binding]; other site 512565001562 alphaNTD - beta interaction site [polypeptide binding]; other site 512565001563 alphaNTD - beta' interaction site [polypeptide binding]; other site 512565001564 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 512565001565 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 512565001566 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 512565001567 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 512565001568 dimerization interface 3.5A [polypeptide binding]; other site 512565001569 active site 512565001570 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565001571 S-adenosylmethionine binding site [chemical binding]; other site 512565001572 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512565001573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565001574 Walker A/P-loop; other site 512565001575 ATP binding site [chemical binding]; other site 512565001576 Q-loop/lid; other site 512565001577 ABC transporter signature motif; other site 512565001578 Walker B; other site 512565001579 D-loop; other site 512565001580 H-loop/switch region; other site 512565001581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565001582 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 512565001583 thiamine phosphate binding site [chemical binding]; other site 512565001584 active site 512565001585 pyrophosphate binding site [ion binding]; other site 512565001586 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 512565001587 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 512565001588 thiS-thiF/thiG interaction site; other site 512565001589 thiazole synthase; Reviewed; Region: thiG; PRK00208 512565001590 phosphate binding site [ion binding]; other site 512565001591 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 512565001592 thiamine phosphate binding site [chemical binding]; other site 512565001593 active site 512565001594 pyrophosphate binding site [ion binding]; other site 512565001595 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 512565001596 dimer interface [polypeptide binding]; other site 512565001597 substrate binding site [chemical binding]; other site 512565001598 ATP binding site [chemical binding]; other site 512565001599 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 512565001600 ThiC-associated domain; Region: ThiC-associated; pfam13667 512565001601 ThiC family; Region: ThiC; pfam01964 512565001602 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 512565001603 Catalytic site [active] 512565001604 DDE superfamily endonuclease; Region: DDE_5; pfam13546 512565001605 ribonuclease; Region: Ribonuclease; pfam00545 512565001606 active site 512565001607 Topoisomerase II-associated protein PAT1; Region: PAT1; pfam09770 512565001608 Nitrate and nitrite sensing; Region: NIT; pfam08376 512565001609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565001610 ATP binding site [chemical binding]; other site 512565001611 Mg2+ binding site [ion binding]; other site 512565001612 G-X-G motif; other site 512565001613 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 512565001614 Protein of unknown function (DUF742); Region: DUF742; pfam05331 512565001615 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565001616 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 512565001617 G1 box; other site 512565001618 GTP/Mg2+ binding site [chemical binding]; other site 512565001619 G2 box; other site 512565001620 Switch I region; other site 512565001621 G3 box; other site 512565001622 Switch II region; other site 512565001623 G4 box; other site 512565001624 G5 box; other site 512565001625 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 512565001626 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 512565001627 active site 512565001628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 512565001629 DNA binding site [nucleotide binding] 512565001630 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 512565001631 23S rRNA interface [nucleotide binding]; other site 512565001632 L3 interface [polypeptide binding]; other site 512565001633 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 512565001634 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 512565001635 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 512565001636 active site 512565001637 substrate binding site [chemical binding]; other site 512565001638 metal binding site [ion binding]; metal-binding site 512565001639 aminotransferase; Validated; Region: PRK07777 512565001640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565001641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565001642 homodimer interface [polypeptide binding]; other site 512565001643 catalytic residue [active] 512565001644 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 512565001645 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 512565001646 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 512565001647 glutaminase active site [active] 512565001648 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 512565001649 dimer interface [polypeptide binding]; other site 512565001650 active site 512565001651 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 512565001652 dimer interface [polypeptide binding]; other site 512565001653 active site 512565001654 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 512565001655 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 512565001656 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 512565001657 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 512565001658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 512565001659 alanine racemase; Reviewed; Region: alr; PRK00053 512565001660 active site 512565001661 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565001662 dimer interface [polypeptide binding]; other site 512565001663 substrate binding site [chemical binding]; other site 512565001664 catalytic residues [active] 512565001665 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565001666 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565001667 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565001668 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 512565001669 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 512565001670 ligand binding site [chemical binding]; other site 512565001671 active site 512565001672 UGI interface [polypeptide binding]; other site 512565001673 catalytic site [active] 512565001674 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 512565001675 Glycoprotease family; Region: Peptidase_M22; pfam00814 512565001676 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 512565001677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565001678 Coenzyme A binding pocket [chemical binding]; other site 512565001679 UGMP family protein; Validated; Region: PRK09604 512565001680 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 512565001681 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565001682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565001683 ABC transporter signature motif; other site 512565001684 Walker B; other site 512565001685 D-loop; other site 512565001686 H-loop/switch region; other site 512565001687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565001688 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565001689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565001690 Walker A/P-loop; other site 512565001691 ATP binding site [chemical binding]; other site 512565001692 Q-loop/lid; other site 512565001693 ABC transporter signature motif; other site 512565001694 Walker B; other site 512565001695 D-loop; other site 512565001696 H-loop/switch region; other site 512565001697 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 512565001698 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 512565001699 ring oligomerisation interface [polypeptide binding]; other site 512565001700 ATP/Mg binding site [chemical binding]; other site 512565001701 stacking interactions; other site 512565001702 hinge regions; other site 512565001703 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 512565001704 oligomerisation interface [polypeptide binding]; other site 512565001705 mobile loop; other site 512565001706 roof hairpin; other site 512565001707 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 512565001708 putative deacylase active site [active] 512565001709 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 512565001710 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 512565001711 putative ligand binding site [chemical binding]; other site 512565001712 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565001713 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565001714 Walker A/P-loop; other site 512565001715 ATP binding site [chemical binding]; other site 512565001716 Q-loop/lid; other site 512565001717 ABC transporter signature motif; other site 512565001718 Walker B; other site 512565001719 D-loop; other site 512565001720 H-loop/switch region; other site 512565001721 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565001722 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565001723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565001724 TM-ABC transporter signature motif; other site 512565001725 MarR family; Region: MarR_2; pfam12802 512565001726 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565001727 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565001728 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 512565001729 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512565001730 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512565001731 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 512565001732 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 512565001733 Moco binding site; other site 512565001734 metal coordination site [ion binding]; other site 512565001735 dimerization interface [polypeptide binding]; other site 512565001736 Transcription factor WhiB; Region: Whib; pfam02467 512565001737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565001738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565001739 DNA binding residues [nucleotide binding] 512565001740 dimerization interface [polypeptide binding]; other site 512565001741 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 512565001742 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512565001743 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 512565001744 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 512565001745 active site 512565001746 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 512565001747 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512565001748 phosphate binding site [ion binding]; other site 512565001749 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 512565001750 Zn binding site [ion binding]; other site 512565001751 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 512565001752 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 512565001753 active site 512565001754 catalytic triad [active] 512565001755 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 512565001756 GMP synthase; Reviewed; Region: guaA; PRK00074 512565001757 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 512565001758 AMP/PPi binding site [chemical binding]; other site 512565001759 candidate oxyanion hole; other site 512565001760 catalytic triad [active] 512565001761 potential glutamine specificity residues [chemical binding]; other site 512565001762 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 512565001763 ATP Binding subdomain [chemical binding]; other site 512565001764 Ligand Binding sites [chemical binding]; other site 512565001765 Dimerization subdomain; other site 512565001766 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 512565001767 nudix motif; other site 512565001768 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565001769 nudix motif; other site 512565001770 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565001771 nudix motif; other site 512565001772 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565001773 nudix motif; other site 512565001774 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 512565001775 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 512565001776 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 512565001777 PspC domain; Region: PspC; pfam04024 512565001778 PspC domain; Region: PspC; cl00864 512565001779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565001780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565001781 ATP binding site [chemical binding]; other site 512565001782 G-X-G motif; other site 512565001783 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565001784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565001785 active site 512565001786 phosphorylation site [posttranslational modification] 512565001787 intermolecular recognition site; other site 512565001788 dimerization interface [polypeptide binding]; other site 512565001789 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565001790 DNA binding residues [nucleotide binding] 512565001791 dimerization interface [polypeptide binding]; other site 512565001792 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 512565001793 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 512565001794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565001795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565001796 dimer interface [polypeptide binding]; other site 512565001797 conserved gate region; other site 512565001798 putative PBP binding loops; other site 512565001799 ABC-ATPase subunit interface; other site 512565001800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512565001801 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 512565001802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565001803 dimer interface [polypeptide binding]; other site 512565001804 conserved gate region; other site 512565001805 putative PBP binding loops; other site 512565001806 ABC-ATPase subunit interface; other site 512565001807 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565001808 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565001809 Walker A/P-loop; other site 512565001810 ATP binding site [chemical binding]; other site 512565001811 Q-loop/lid; other site 512565001812 ABC transporter signature motif; other site 512565001813 Walker B; other site 512565001814 D-loop; other site 512565001815 H-loop/switch region; other site 512565001816 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 512565001817 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 512565001818 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565001819 Walker A/P-loop; other site 512565001820 ATP binding site [chemical binding]; other site 512565001821 Q-loop/lid; other site 512565001822 ABC transporter signature motif; other site 512565001823 Walker B; other site 512565001824 D-loop; other site 512565001825 H-loop/switch region; other site 512565001826 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565001827 Chorismate mutase type II; Region: CM_2; cl00693 512565001828 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 512565001829 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 512565001830 putative active site [active] 512565001831 putative metal binding site [ion binding]; other site 512565001832 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 512565001833 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 512565001834 Part of AAA domain; Region: AAA_19; pfam13245 512565001835 Family description; Region: UvrD_C_2; pfam13538 512565001836 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565001837 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565001838 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565001839 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565001840 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 512565001841 B12 binding site [chemical binding]; other site 512565001842 cobalt ligand [ion binding]; other site 512565001843 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 512565001844 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 512565001845 CoA-ligase; Region: Ligase_CoA; pfam00549 512565001846 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 512565001847 CoA binding domain; Region: CoA_binding; smart00881 512565001848 CoA-ligase; Region: Ligase_CoA; pfam00549 512565001849 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 512565001850 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 512565001851 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 512565001852 active site 512565001853 substrate binding site [chemical binding]; other site 512565001854 cosubstrate binding site; other site 512565001855 catalytic site [active] 512565001856 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 512565001857 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 512565001858 purine monophosphate binding site [chemical binding]; other site 512565001859 dimer interface [polypeptide binding]; other site 512565001860 putative catalytic residues [active] 512565001861 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 512565001862 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 512565001863 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 512565001864 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565001865 putative active site [active] 512565001866 isocitrate dehydrogenase; Validated; Region: PRK08299 512565001867 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 512565001868 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 512565001869 putative catalytic cysteine [active] 512565001870 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 512565001871 putative active site [active] 512565001872 metal binding site [ion binding]; metal-binding site 512565001873 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 512565001874 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 512565001875 dimer interface [polypeptide binding]; other site 512565001876 active site 512565001877 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512565001878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565001879 DNA-binding site [nucleotide binding]; DNA binding site 512565001880 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512565001881 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565001882 active site 512565001883 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 512565001884 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 512565001885 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 512565001886 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565001887 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 512565001888 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 512565001889 Chain length determinant protein; Region: Wzz; cl15801 512565001890 Chain length determinant protein; Region: Wzz; cl15801 512565001891 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 512565001892 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 512565001893 PUA-like domain; Region: PUA_2; pfam14306 512565001894 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 512565001895 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 512565001896 ligand-binding site [chemical binding]; other site 512565001897 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 512565001898 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565001899 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 512565001900 Walker A/P-loop; other site 512565001901 ATP binding site [chemical binding]; other site 512565001902 Q-loop/lid; other site 512565001903 ABC transporter signature motif; other site 512565001904 Walker B; other site 512565001905 D-loop; other site 512565001906 H-loop/switch region; other site 512565001907 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 512565001908 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 512565001909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565001910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565001911 Walker A/P-loop; other site 512565001912 ATP binding site [chemical binding]; other site 512565001913 Q-loop/lid; other site 512565001914 ABC transporter signature motif; other site 512565001915 Walker B; other site 512565001916 D-loop; other site 512565001917 H-loop/switch region; other site 512565001918 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 512565001919 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 512565001920 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 512565001921 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 512565001922 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 512565001923 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 512565001924 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 512565001925 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 512565001926 DXD motif; other site 512565001927 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 512565001928 putative active site [active] 512565001929 putative substrate binding site [chemical binding]; other site 512565001930 putative cosubstrate binding site; other site 512565001931 catalytic site [active] 512565001932 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 512565001933 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565001934 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565001935 substrate binding site [chemical binding]; other site 512565001936 oxyanion hole (OAH) forming residues; other site 512565001937 trimer interface [polypeptide binding]; other site 512565001938 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 512565001939 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 512565001940 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565001941 ATP binding site [chemical binding]; other site 512565001942 putative Mg++ binding site [ion binding]; other site 512565001943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565001944 nucleotide binding region [chemical binding]; other site 512565001945 ATP-binding site [chemical binding]; other site 512565001946 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 512565001947 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 512565001948 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 512565001949 homodimer interface [polypeptide binding]; other site 512565001950 metal binding site [ion binding]; metal-binding site 512565001951 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 512565001952 enolase; Provisional; Region: eno; PRK00077 512565001953 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 512565001954 dimer interface [polypeptide binding]; other site 512565001955 metal binding site [ion binding]; metal-binding site 512565001956 substrate binding pocket [chemical binding]; other site 512565001957 Septum formation initiator; Region: DivIC; pfam04977 512565001958 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 512565001959 Uncharacterized conserved protein [Function unknown]; Region: COG1507 512565001960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565001961 Coenzyme A binding pocket [chemical binding]; other site 512565001962 exopolyphosphatase; Region: exo_poly_only; TIGR03706 512565001963 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 512565001964 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565001965 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565001966 Predicted membrane protein [Function unknown]; Region: COG4709 512565001967 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 512565001968 Fe-S cluster binding site [ion binding]; other site 512565001969 DNA binding site [nucleotide binding] 512565001970 active site 512565001971 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 512565001972 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565001973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565001974 Walker A motif; other site 512565001975 ATP binding site [chemical binding]; other site 512565001976 Walker B motif; other site 512565001977 arginine finger; other site 512565001978 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 512565001979 Protein of unknown function DUF58; Region: DUF58; pfam01882 512565001980 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 512565001981 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565001982 Bax inhibitor 1 like; Region: BaxI_1; cl17691 512565001983 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565001984 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512565001985 Coenzyme A binding pocket [chemical binding]; other site 512565001986 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 512565001987 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565001988 dimer interface [polypeptide binding]; other site 512565001989 active site 512565001990 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 512565001991 active site 512565001992 catalytic triad [active] 512565001993 oxyanion hole [active] 512565001994 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 512565001995 active site 512565001996 catalytic triad [active] 512565001997 oxyanion hole [active] 512565001998 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 512565001999 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 512565002000 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 512565002001 dimer interface [polypeptide binding]; other site 512565002002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565002003 catalytic residue [active] 512565002004 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 512565002005 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565002006 active site 512565002007 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565002008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565002009 Coenzyme A binding pocket [chemical binding]; other site 512565002010 ribonuclease Z; Reviewed; Region: PRK00055 512565002011 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 512565002012 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 512565002013 putative active site; other site 512565002014 putative metal binding residues [ion binding]; other site 512565002015 signature motif; other site 512565002016 putative triphosphate binding site [ion binding]; other site 512565002017 CHAD domain; Region: CHAD; pfam05235 512565002018 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 512565002019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565002020 binding surface 512565002021 TPR motif; other site 512565002022 TPR repeat; Region: TPR_11; pfam13414 512565002023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565002024 TPR motif; other site 512565002025 binding surface 512565002026 Restriction endonuclease; Region: Mrr_cat; pfam04471 512565002027 Transcriptional regulators [Transcription]; Region: FadR; COG2186 512565002028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565002029 DNA-binding site [nucleotide binding]; DNA binding site 512565002030 methionine sulfoxide reductase A; Provisional; Region: PRK00058 512565002031 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 512565002032 nucleotide binding site/active site [active] 512565002033 HIT family signature motif; other site 512565002034 catalytic residue [active] 512565002035 cystathionine gamma-synthase; Provisional; Region: PRK07811 512565002036 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 512565002037 homodimer interface [polypeptide binding]; other site 512565002038 substrate-cofactor binding pocket; other site 512565002039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565002040 catalytic residue [active] 512565002041 amidase; Provisional; Region: PRK12470 512565002042 Amidase; Region: Amidase; cl11426 512565002043 threonine dehydratase; Provisional; Region: PRK08198 512565002044 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 512565002045 tetramer interface [polypeptide binding]; other site 512565002046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565002047 catalytic residue [active] 512565002048 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 512565002049 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 512565002050 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 512565002051 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 512565002052 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 512565002053 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 512565002054 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565002055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565002056 metal binding site [ion binding]; metal-binding site 512565002057 active site 512565002058 I-site; other site 512565002059 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565002060 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565002061 AAA domain; Region: AAA_14; pfam13173 512565002062 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 512565002063 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 512565002064 catalytic residues [active] 512565002065 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 512565002066 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 512565002067 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565002068 putative active site [active] 512565002069 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 512565002070 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565002071 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 512565002072 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565002073 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565002074 active site 512565002075 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565002076 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565002077 DNA binding site [nucleotide binding] 512565002078 domain linker motif; other site 512565002079 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565002080 dimerization interface [polypeptide binding]; other site 512565002081 ligand binding site [chemical binding]; other site 512565002082 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565002083 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565002084 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565002085 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 512565002086 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 512565002087 FMN-binding pocket [chemical binding]; other site 512565002088 flavin binding motif; other site 512565002089 phosphate binding motif [ion binding]; other site 512565002090 beta-alpha-beta structure motif; other site 512565002091 NAD binding pocket [chemical binding]; other site 512565002092 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565002093 catalytic loop [active] 512565002094 iron binding site [ion binding]; other site 512565002095 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565002096 Cytochrome P450; Region: p450; cl12078 512565002097 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 512565002098 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 512565002099 NAD binding site [chemical binding]; other site 512565002100 catalytic Zn binding site [ion binding]; other site 512565002101 substrate binding site [chemical binding]; other site 512565002102 structural Zn binding site [ion binding]; other site 512565002103 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565002104 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565002105 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 512565002106 substrate binding pocket [chemical binding]; other site 512565002107 dimerization interface [polypeptide binding]; other site 512565002108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565002109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565002110 DNA binding site [nucleotide binding] 512565002111 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565002112 ligand binding site [chemical binding]; other site 512565002113 dimerization interface [polypeptide binding]; other site 512565002114 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565002115 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565002117 dimer interface [polypeptide binding]; other site 512565002118 conserved gate region; other site 512565002119 putative PBP binding loops; other site 512565002120 ABC-ATPase subunit interface; other site 512565002121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565002122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565002123 dimer interface [polypeptide binding]; other site 512565002124 conserved gate region; other site 512565002125 putative PBP binding loops; other site 512565002126 ABC-ATPase subunit interface; other site 512565002127 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565002128 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 512565002129 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565002130 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565002131 DNA binding site [nucleotide binding] 512565002132 domain linker motif; other site 512565002133 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565002134 dimerization interface [polypeptide binding]; other site 512565002135 ligand binding site [chemical binding]; other site 512565002136 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 512565002137 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512565002138 Domain of unknown function DUF20; Region: UPF0118; pfam01594 512565002139 GAF domain; Region: GAF; cl17456 512565002140 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 512565002141 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565002142 GAF domain; Region: GAF; cl17456 512565002143 ANTAR domain; Region: ANTAR; pfam03861 512565002144 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 512565002145 putative di-iron ligands [ion binding]; other site 512565002146 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 512565002147 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565002148 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565002149 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 512565002150 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565002151 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565002152 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565002153 DNA binding site [nucleotide binding] 512565002154 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565002155 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 512565002156 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565002157 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565002158 putative sugar binding sites [chemical binding]; other site 512565002159 Q-X-W motif; other site 512565002160 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565002161 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 512565002162 AsnC family; Region: AsnC_trans_reg; pfam01037 512565002163 dimerization interface [polypeptide binding]; other site 512565002164 putative DNA binding site [nucleotide binding]; other site 512565002165 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565002166 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 512565002167 putative Zn2+ binding site [ion binding]; other site 512565002168 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 512565002169 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 512565002170 metal binding site [ion binding]; metal-binding site 512565002171 dimer interface [polypeptide binding]; other site 512565002172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565002173 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 512565002174 Mg++ binding site [ion binding]; other site 512565002175 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 512565002176 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 512565002177 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565002178 acyl-activating enzyme (AAE) consensus motif; other site 512565002179 AMP binding site [chemical binding]; other site 512565002180 active site 512565002181 CoA binding site [chemical binding]; other site 512565002182 TIGR03089 family protein; Region: TIGR03089 512565002183 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 512565002184 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565002185 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 512565002186 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 512565002187 Substrate binding site; other site 512565002188 Cupin domain; Region: Cupin_2; cl17218 512565002189 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 512565002190 nudix motif; other site 512565002191 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 512565002192 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 512565002193 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 512565002194 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 512565002195 phosphate binding site [ion binding]; other site 512565002196 dimer interface [polypeptide binding]; other site 512565002197 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit; Region: F420_cofG; TIGR03550 512565002198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565002199 FeS/SAM binding site; other site 512565002200 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 512565002201 Transcription factor WhiB; Region: Whib; pfam02467 512565002202 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 512565002203 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 512565002204 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565002205 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565002206 NodB motif; other site 512565002207 active site 512565002208 catalytic site [active] 512565002209 metal binding site [ion binding]; metal-binding site 512565002210 Protein of unknown function (DUF779); Region: DUF779; pfam05610 512565002211 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 512565002212 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565002213 NAD(P) binding site [chemical binding]; other site 512565002214 catalytic residues [active] 512565002215 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 512565002216 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 512565002217 Active_site [active] 512565002218 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 512565002219 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 512565002220 active site 512565002221 substrate binding site [chemical binding]; other site 512565002222 metal binding site [ion binding]; metal-binding site 512565002223 Uncharacterized conserved protein [Function unknown]; Region: COG2835 512565002224 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 512565002225 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 512565002226 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 512565002227 dimer interface [polypeptide binding]; other site 512565002228 active site 512565002229 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 512565002230 Cation efflux family; Region: Cation_efflux; pfam01545 512565002231 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 512565002232 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 512565002233 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 512565002234 Adenosylhomocysteinase; Provisional; Region: PTZ00075 512565002235 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 512565002236 homotetramer interface [polypeptide binding]; other site 512565002237 ligand binding site [chemical binding]; other site 512565002238 catalytic site [active] 512565002239 NAD binding site [chemical binding]; other site 512565002240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565002241 sequence-specific DNA binding site [nucleotide binding]; other site 512565002242 salt bridge; other site 512565002243 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565002244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565002245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565002246 active site 512565002247 phosphorylation site [posttranslational modification] 512565002248 intermolecular recognition site; other site 512565002249 dimerization interface [polypeptide binding]; other site 512565002250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565002251 DNA binding site [nucleotide binding] 512565002252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565002253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565002254 dimer interface [polypeptide binding]; other site 512565002255 phosphorylation site [posttranslational modification] 512565002256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565002257 ATP binding site [chemical binding]; other site 512565002258 Mg2+ binding site [ion binding]; other site 512565002259 G-X-G motif; other site 512565002260 lipoprotein LpqB; Provisional; Region: PRK13616 512565002261 Sporulation and spore germination; Region: Germane; pfam10646 512565002262 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 512565002263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565002264 active site 512565002265 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 512565002266 30S subunit binding site; other site 512565002267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565002268 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565002269 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 512565002270 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 512565002271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 512565002272 nucleotide binding region [chemical binding]; other site 512565002273 SEC-C motif; Region: SEC-C; pfam02810 512565002274 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565002275 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 512565002276 putative DNA binding site [nucleotide binding]; other site 512565002277 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565002278 putative Zn2+ binding site [ion binding]; other site 512565002279 peptide chain release factor 2; Validated; Region: prfB; PRK00578 512565002280 This domain is found in peptide chain release factors; Region: PCRF; smart00937 512565002281 RF-1 domain; Region: RF-1; pfam00472 512565002282 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 512565002283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565002284 Walker A/P-loop; other site 512565002285 ATP binding site [chemical binding]; other site 512565002286 Q-loop/lid; other site 512565002287 ABC transporter signature motif; other site 512565002288 Walker B; other site 512565002289 D-loop; other site 512565002290 H-loop/switch region; other site 512565002291 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 512565002292 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 512565002293 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565002294 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565002295 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 512565002296 SmpB-tmRNA interface; other site 512565002297 Cellulose binding domain; Region: CBM_2; cl17741 512565002298 MarR family; Region: MarR_2; cl17246 512565002299 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565002300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565002301 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565002302 NAD(P) binding site [chemical binding]; other site 512565002303 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 512565002304 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 512565002305 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 512565002306 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 512565002307 hypothetical protein; Validated; Region: PRK00228 512565002308 Pilus assembly protein, PilO; Region: PilO; cl01234 512565002309 Competence protein A; Region: Competence_A; pfam11104 512565002310 Cell division protein FtsA; Region: FtsA; cl17206 512565002311 Cell division protein FtsA; Region: FtsA; pfam14450 512565002312 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 512565002313 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 512565002314 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 512565002315 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 512565002316 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 512565002317 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 512565002318 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 512565002319 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565002320 Walker A motif; other site 512565002321 ATP binding site [chemical binding]; other site 512565002322 Walker B motif; other site 512565002323 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 512565002324 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 512565002325 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 512565002326 Walker A motif; other site 512565002327 ATP binding site [chemical binding]; other site 512565002328 Walker B motif; other site 512565002329 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 512565002330 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 512565002331 conserved cys residue [active] 512565002332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565002333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565002334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565002335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565002336 putative substrate translocation pore; other site 512565002337 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565002338 anti sigma factor interaction site; other site 512565002339 regulatory phosphorylation site [posttranslational modification]; other site 512565002340 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565002341 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565002342 Tetratricopeptide repeat; Region: TPR_10; pfam13374 512565002343 Tetratricopeptide repeat; Region: TPR_10; pfam13374 512565002344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565002345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565002346 metal binding site [ion binding]; metal-binding site 512565002347 active site 512565002348 I-site; other site 512565002349 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565002350 HEXXH motif domain; Region: mod_HExxH; TIGR04267 512565002351 Domain of unknown function (DUF427); Region: DUF427; pfam04248 512565002352 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565002353 GAF domain; Region: GAF; pfam01590 512565002354 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565002355 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 512565002356 polymerase nucleotide-binding site; other site 512565002357 DNA-binding residues [nucleotide binding]; DNA binding site 512565002358 nucleotide binding site [chemical binding]; other site 512565002359 primase nucleotide-binding site [nucleotide binding]; other site 512565002360 Part of AAA domain; Region: AAA_19; pfam13245 512565002361 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565002362 AAA domain; Region: AAA_12; pfam13087 512565002363 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565002364 Walker A motif; other site 512565002365 ATP binding site [chemical binding]; other site 512565002366 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565002367 AAA domain; Region: AAA_12; pfam13087 512565002368 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565002369 putative active site [active] 512565002370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565002371 PAS fold; Region: PAS_3; pfam08447 512565002372 putative active site [active] 512565002373 heme pocket [chemical binding]; other site 512565002374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565002375 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 512565002376 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565002377 MarR family; Region: MarR; pfam01047 512565002378 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 512565002379 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 512565002380 active site 512565002381 DNA binding site [nucleotide binding] 512565002382 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565002383 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 512565002384 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 512565002385 D-pathway; other site 512565002386 Putative ubiquinol binding site [chemical binding]; other site 512565002387 Low-spin heme (heme b) binding site [chemical binding]; other site 512565002388 Putative water exit pathway; other site 512565002389 Binuclear center (heme o3/CuB) [ion binding]; other site 512565002390 K-pathway; other site 512565002391 Putative proton exit pathway; other site 512565002392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565002393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565002394 putative substrate translocation pore; other site 512565002395 Serine hydrolase; Region: Ser_hydrolase; pfam06821 512565002396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565002397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512565002398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565002399 Coenzyme A binding pocket [chemical binding]; other site 512565002400 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 512565002401 Isochorismatase family; Region: Isochorismatase; pfam00857 512565002402 catalytic triad [active] 512565002403 conserved cis-peptide bond; other site 512565002404 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 512565002405 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 512565002406 active site 512565002407 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 512565002408 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 512565002409 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 512565002410 MPN+ (JAMM) motif; other site 512565002411 Zinc-binding site [ion binding]; other site 512565002412 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 512565002413 MoaE interaction surface [polypeptide binding]; other site 512565002414 MoeB interaction surface [polypeptide binding]; other site 512565002415 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 512565002416 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 512565002417 dimer interface [polypeptide binding]; other site 512565002418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565002419 catalytic residue [active] 512565002420 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 512565002421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565002422 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 512565002423 ribonuclease PH; Reviewed; Region: rph; PRK00173 512565002424 Ribonuclease PH; Region: RNase_PH_bact; cd11362 512565002425 hexamer interface [polypeptide binding]; other site 512565002426 active site 512565002427 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 512565002428 active site 512565002429 dimerization interface [polypeptide binding]; other site 512565002430 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 512565002431 active sites [active] 512565002432 tetramer interface [polypeptide binding]; other site 512565002433 imidazolonepropionase; Provisional; Region: PRK14085 512565002434 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 512565002435 active site 512565002436 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565002437 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 512565002438 active site 512565002439 allantoate amidohydrolase; Reviewed; Region: PRK09290 512565002440 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 512565002441 active site 512565002442 metal binding site [ion binding]; metal-binding site 512565002443 dimer interface [polypeptide binding]; other site 512565002444 urocanate hydratase; Provisional; Region: PRK05414 512565002445 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512565002446 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512565002447 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512565002448 putative active site [active] 512565002449 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 512565002450 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 512565002451 MOSC domain; Region: MOSC; pfam03473 512565002452 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 512565002453 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 512565002454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565002455 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565002456 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565002457 Serine hydrolase; Region: Ser_hydrolase; cl17834 512565002458 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 512565002459 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 512565002460 catalytic triad [active] 512565002461 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 512565002462 Asp23 family; Region: Asp23; cl00574 512565002463 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 512565002464 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 512565002465 catalytic residues [active] 512565002466 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 512565002467 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565002468 CopC domain; Region: CopC; pfam04234 512565002469 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 512565002470 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 512565002471 catalytic site [active] 512565002472 putative active site [active] 512565002473 putative substrate binding site [chemical binding]; other site 512565002474 dimer interface [polypeptide binding]; other site 512565002475 Cellulose binding domain; Region: CBM_2; pfam00553 512565002476 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 512565002477 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565002478 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565002479 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565002480 DNA binding residues [nucleotide binding] 512565002481 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 512565002482 transcriptional regulator BetI; Validated; Region: PRK00767 512565002483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565002484 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565002485 Bacterial Ig-like domain; Region: Big_5; pfam13205 512565002486 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 512565002487 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 512565002488 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 512565002489 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 512565002490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 512565002491 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 512565002492 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 512565002493 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565002494 NodB motif; other site 512565002495 active site 512565002496 catalytic site [active] 512565002497 Zn binding site [ion binding]; other site 512565002498 dimer interface [polypeptide binding]; other site 512565002499 CBD_II domain; Region: CBD_II; smart00637 512565002500 SEC-C motif; Region: SEC-C; pfam02810 512565002501 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 512565002502 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565002503 Predicted flavoprotein [General function prediction only]; Region: COG0431 512565002504 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 512565002505 Sulfatase; Region: Sulfatase; pfam00884 512565002506 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565002507 Cytochrome P450; Region: p450; cl12078 512565002508 Domain of unknown function (DUF305); Region: DUF305; pfam03713 512565002509 Uncharacterized conserved protein [Function unknown]; Region: COG5276 512565002510 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565002511 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565002512 non-specific DNA binding site [nucleotide binding]; other site 512565002513 salt bridge; other site 512565002514 sequence-specific DNA binding site [nucleotide binding]; other site 512565002515 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 512565002516 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 512565002517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565002518 Coenzyme A binding pocket [chemical binding]; other site 512565002519 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 512565002520 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565002521 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 512565002522 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 512565002523 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565002524 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565002525 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565002526 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 512565002527 ligand binding site [chemical binding]; other site 512565002528 MarR family; Region: MarR_2; pfam12802 512565002529 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565002530 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565002531 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565002532 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512565002533 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 512565002534 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565002536 dimer interface [polypeptide binding]; other site 512565002537 conserved gate region; other site 512565002538 ABC-ATPase subunit interface; other site 512565002539 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 512565002540 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 512565002541 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 512565002542 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 512565002543 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 512565002544 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 512565002545 conserved cys residue [active] 512565002546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565002547 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 512565002548 active site residue [active] 512565002549 FAD binding domain; Region: FAD_binding_4; pfam01565 512565002550 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 512565002551 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565002552 Transcriptional regulator PadR-like family; Region: PadR; cl17335 512565002553 Response regulator receiver domain; Region: Response_reg; pfam00072 512565002554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565002555 active site 512565002556 phosphorylation site [posttranslational modification] 512565002557 intermolecular recognition site; other site 512565002558 dimerization interface [polypeptide binding]; other site 512565002559 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565002560 GAF domain; Region: GAF; pfam01590 512565002561 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 512565002562 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 512565002563 PRC-barrel domain; Region: PRC; pfam05239 512565002564 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 512565002565 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 512565002566 oligomer interface [polypeptide binding]; other site 512565002567 metal binding site [ion binding]; metal-binding site 512565002568 metal binding site [ion binding]; metal-binding site 512565002569 putative Cl binding site [ion binding]; other site 512565002570 basic sphincter; other site 512565002571 hydrophobic gate; other site 512565002572 periplasmic entrance; other site 512565002573 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565002574 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565002575 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565002576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565002577 Walker A/P-loop; other site 512565002578 ATP binding site [chemical binding]; other site 512565002579 Q-loop/lid; other site 512565002580 ABC transporter signature motif; other site 512565002581 Walker B; other site 512565002582 D-loop; other site 512565002583 H-loop/switch region; other site 512565002584 Predicted transcriptional regulator [Transcription]; Region: COG2378 512565002585 HTH domain; Region: HTH_11; pfam08279 512565002586 WYL domain; Region: WYL; pfam13280 512565002587 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 512565002588 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 512565002589 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 512565002590 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 512565002591 active site 512565002592 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565002593 Cytochrome P450; Region: p450; cl12078 512565002594 Nitrate and nitrite sensing; Region: NIT; pfam08376 512565002595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 512565002596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565002597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565002598 ATP binding site [chemical binding]; other site 512565002599 Mg2+ binding site [ion binding]; other site 512565002600 G-X-G motif; other site 512565002601 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 512565002602 Protein of unknown function (DUF742); Region: DUF742; pfam05331 512565002603 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565002604 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 512565002605 G1 box; other site 512565002606 GTP/Mg2+ binding site [chemical binding]; other site 512565002607 G2 box; other site 512565002608 Switch I region; other site 512565002609 G3 box; other site 512565002610 Switch II region; other site 512565002611 G4 box; other site 512565002612 G5 box; other site 512565002613 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565002614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565002615 DNA binding site [nucleotide binding] 512565002616 domain linker motif; other site 512565002617 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565002618 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 512565002619 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 512565002620 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565002621 metal ion-dependent adhesion site (MIDAS); other site 512565002622 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565002623 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565002624 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 512565002625 xylose isomerase; Provisional; Region: PRK12677 512565002626 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565002627 D-xylulose kinase; Region: XylB; TIGR01312 512565002628 nucleotide binding site [chemical binding]; other site 512565002629 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565002630 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565002631 putative sugar binding sites [chemical binding]; other site 512565002632 Q-X-W motif; other site 512565002633 putative pectinesterase; Region: PLN02432; cl01911 512565002634 Pectinesterase; Region: Pectinesterase; pfam01095 512565002635 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565002636 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565002637 putative sugar binding sites [chemical binding]; other site 512565002638 Q-X-W motif; other site 512565002639 Pectate lyase; Region: Pec_lyase_C; cl01593 512565002640 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 512565002641 active site 512565002642 catalytic triad [active] 512565002643 oxyanion hole [active] 512565002644 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 512565002645 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 512565002646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565002647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565002648 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 512565002649 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512565002650 active site 512565002651 catalytic site [active] 512565002652 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 512565002653 HD domain; Region: HD_4; pfam13328 512565002654 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 512565002655 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512565002656 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 512565002657 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512565002658 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 512565002659 active site 512565002660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565002661 NAD(P) binding site [chemical binding]; other site 512565002662 active site 512565002663 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 512565002664 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 512565002665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565002666 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565002667 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565002668 DNA binding residues [nucleotide binding] 512565002669 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 512565002670 NlpC/P60 family; Region: NLPC_P60; pfam00877 512565002671 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 512565002672 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 512565002673 ANTAR domain; Region: ANTAR; pfam03861 512565002674 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 512565002675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565002676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565002677 putative substrate translocation pore; other site 512565002678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565002679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565002680 putative DNA binding site [nucleotide binding]; other site 512565002681 putative Zn2+ binding site [ion binding]; other site 512565002682 Predicted methyltransferase [General function prediction only]; Region: COG3897 512565002683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565002684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565002685 active site 512565002686 phosphorylation site [posttranslational modification] 512565002687 intermolecular recognition site; other site 512565002688 dimerization interface [polypeptide binding]; other site 512565002689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565002690 DNA binding residues [nucleotide binding] 512565002691 dimerization interface [polypeptide binding]; other site 512565002692 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 512565002693 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 512565002694 ligand binding site [chemical binding]; other site 512565002695 NAD binding site [chemical binding]; other site 512565002696 tetramer interface [polypeptide binding]; other site 512565002697 catalytic site [active] 512565002698 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 512565002699 L-serine binding site [chemical binding]; other site 512565002700 ACT domain interface; other site 512565002701 Phosphotransferase enzyme family; Region: APH; pfam01636 512565002702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565002703 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 512565002704 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565002705 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 512565002706 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 512565002707 dimer interface [polypeptide binding]; other site 512565002708 ssDNA binding site [nucleotide binding]; other site 512565002709 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512565002710 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 512565002711 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565002712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565002713 putative DNA binding site [nucleotide binding]; other site 512565002714 putative Zn2+ binding site [ion binding]; other site 512565002715 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 512565002716 putative hydrophobic ligand binding site [chemical binding]; other site 512565002717 cobyric acid synthase; Provisional; Region: PRK00784 512565002718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565002719 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 512565002720 catalytic triad [active] 512565002721 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 512565002722 hypothetical protein; Provisional; Region: PRK07907 512565002723 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 512565002724 active site 512565002725 metal binding site [ion binding]; metal-binding site 512565002726 dimer interface [polypeptide binding]; other site 512565002727 FAD binding domain; Region: FAD_binding_3; pfam01494 512565002728 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565002729 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 512565002730 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 512565002731 active site 512565002732 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 512565002733 DNA binding site [nucleotide binding] 512565002734 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 512565002735 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 512565002736 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512565002737 conserved cys residue [active] 512565002738 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565002739 TIGR03086 family protein; Region: TIGR03086 512565002740 Transglycosylase; Region: Transgly; pfam00912 512565002741 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 512565002742 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512565002743 hypothetical protein; Provisional; Region: PRK07908 512565002744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565002745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565002746 homodimer interface [polypeptide binding]; other site 512565002747 catalytic residue [active] 512565002748 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 512565002749 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 512565002750 putative dimer interface [polypeptide binding]; other site 512565002751 active site pocket [active] 512565002752 putative cataytic base [active] 512565002753 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 512565002754 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 512565002755 active site 512565002756 SAM binding site [chemical binding]; other site 512565002757 homodimer interface [polypeptide binding]; other site 512565002758 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 512565002759 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 512565002760 active site 512565002761 homotetramer interface [polypeptide binding]; other site 512565002762 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 512565002763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565002764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565002765 ABC transporter; Region: ABC_tran_2; pfam12848 512565002766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565002767 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512565002768 active site 512565002769 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 512565002770 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 512565002771 apolar tunnel; other site 512565002772 heme binding site [chemical binding]; other site 512565002773 dimerization interface [polypeptide binding]; other site 512565002774 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565002775 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 512565002776 Mechanosensitive ion channel; Region: MS_channel; pfam00924 512565002777 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 512565002778 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 512565002779 active site 512565002780 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 512565002781 active site 512565002782 putative catalytic site [active] 512565002783 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565002784 Repair protein; Region: Repair_PSII; cl01535 512565002785 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565002786 putative active site [active] 512565002787 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 512565002788 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 512565002789 Zn binding site [ion binding]; other site 512565002790 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 512565002791 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 512565002792 catalytic residues [active] 512565002793 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 512565002794 Uncharacterized conserved protein [Function unknown]; Region: COG4198 512565002795 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565002796 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565002797 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 512565002798 hypothetical protein; Provisional; Region: PRK01346 512565002799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565002800 Coenzyme A binding pocket [chemical binding]; other site 512565002801 LysE type translocator; Region: LysE; cl00565 512565002802 oxidoreductase; Provisional; Region: PRK06128 512565002803 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 512565002804 NAD binding site [chemical binding]; other site 512565002805 metal binding site [ion binding]; metal-binding site 512565002806 active site 512565002807 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565002808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512565002809 active site 512565002810 Helix-turn-helix domain; Region: HTH_18; pfam12833 512565002811 Helix-turn-helix domain; Region: HTH_20; pfam12840 512565002812 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 512565002813 putative DNA binding site [nucleotide binding]; other site 512565002814 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565002815 hydrophobic ligand binding site; other site 512565002816 trigger factor; Provisional; Region: tig; PRK01490 512565002817 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 512565002818 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 512565002819 Clp protease; Region: CLP_protease; pfam00574 512565002820 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 512565002821 oligomer interface [polypeptide binding]; other site 512565002822 active site residues [active] 512565002823 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 512565002824 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 512565002825 oligomer interface [polypeptide binding]; other site 512565002826 active site residues [active] 512565002827 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 512565002828 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 512565002829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565002830 Walker A motif; other site 512565002831 ATP binding site [chemical binding]; other site 512565002832 Walker B motif; other site 512565002833 arginine finger; other site 512565002834 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 512565002835 nitrilase; Region: PLN02798 512565002836 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 512565002837 putative active site [active] 512565002838 catalytic triad [active] 512565002839 dimer interface [polypeptide binding]; other site 512565002840 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 512565002841 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 512565002842 HIGH motif; other site 512565002843 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 512565002844 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 512565002845 active site 512565002846 KMSKS motif; other site 512565002847 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 512565002848 tRNA binding surface [nucleotide binding]; other site 512565002849 anticodon binding site; other site 512565002850 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 512565002851 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 512565002852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565002853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512565002854 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 512565002855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565002856 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565002857 active site 512565002858 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 512565002859 active site 512565002860 multimer interface [polypeptide binding]; other site 512565002861 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565002862 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565002863 dimerization interface [polypeptide binding]; other site 512565002864 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565002865 dimer interface [polypeptide binding]; other site 512565002866 putative CheW interface [polypeptide binding]; other site 512565002867 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 512565002868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565002869 active site 512565002870 HIGH motif; other site 512565002871 nucleotide binding site [chemical binding]; other site 512565002872 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 512565002873 active site 512565002874 KMSKS motif; other site 512565002875 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 512565002876 tRNA binding surface [nucleotide binding]; other site 512565002877 anticodon binding site; other site 512565002878 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565002879 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565002880 putative acyl-acceptor binding pocket; other site 512565002881 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565002882 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 512565002883 catalytic site [active] 512565002884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565002885 PAS domain; Region: PAS_9; pfam13426 512565002886 putative active site [active] 512565002887 heme pocket [chemical binding]; other site 512565002888 GAF domain; Region: GAF; cl17456 512565002889 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565002890 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565002891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565002892 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565002893 anti sigma factor interaction site; other site 512565002894 regulatory phosphorylation site [posttranslational modification]; other site 512565002895 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 512565002896 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 512565002897 B12 binding site [chemical binding]; other site 512565002898 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565002899 FeS/SAM binding site; other site 512565002900 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 512565002901 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 512565002902 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 512565002903 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 512565002904 homodimer interface [polypeptide binding]; other site 512565002905 oligonucleotide binding site [chemical binding]; other site 512565002906 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 512565002907 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 512565002908 GTPase CgtA; Reviewed; Region: obgE; PRK12296 512565002909 GTP1/OBG; Region: GTP1_OBG; pfam01018 512565002910 Obg GTPase; Region: Obg; cd01898 512565002911 G1 box; other site 512565002912 GTP/Mg2+ binding site [chemical binding]; other site 512565002913 Switch I region; other site 512565002914 G2 box; other site 512565002915 G3 box; other site 512565002916 Switch II region; other site 512565002917 G4 box; other site 512565002918 G5 box; other site 512565002919 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 512565002920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565002921 Coenzyme A binding pocket [chemical binding]; other site 512565002922 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 512565002923 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 512565002924 active site 512565002925 HIGH motif; other site 512565002926 dimer interface [polypeptide binding]; other site 512565002927 KMSKS motif; other site 512565002928 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 512565002929 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 512565002930 Zn binding site [ion binding]; other site 512565002931 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 512565002932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565002933 putative active site [active] 512565002934 heme pocket [chemical binding]; other site 512565002935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565002936 dimer interface [polypeptide binding]; other site 512565002937 phosphorylation site [posttranslational modification] 512565002938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565002939 ATP binding site [chemical binding]; other site 512565002940 Mg2+ binding site [ion binding]; other site 512565002941 G-X-G motif; other site 512565002942 Response regulator receiver domain; Region: Response_reg; pfam00072 512565002943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565002944 active site 512565002945 phosphorylation site [posttranslational modification] 512565002946 intermolecular recognition site; other site 512565002947 dimerization interface [polypeptide binding]; other site 512565002948 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 512565002949 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 512565002950 active site 512565002951 (T/H)XGH motif; other site 512565002952 Oligomerisation domain; Region: Oligomerisation; pfam02410 512565002953 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565002954 catalytic core [active] 512565002955 EDD domain protein, DegV family; Region: DegV; TIGR00762 512565002956 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 512565002957 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 512565002958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565002959 S-adenosylmethionine binding site [chemical binding]; other site 512565002960 comEA protein; Region: comE; TIGR01259 512565002961 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 512565002962 Competence protein; Region: Competence; pfam03772 512565002963 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 512565002964 Competence protein; Region: Competence; pfam03772 512565002965 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 512565002966 DNA polymerase III, delta subunit; Region: holA; TIGR01128 512565002967 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 512565002968 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 512565002969 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565002970 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 512565002971 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 512565002972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 512565002973 GTP-binding protein LepA; Provisional; Region: PRK05433 512565002974 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 512565002975 G1 box; other site 512565002976 putative GEF interaction site [polypeptide binding]; other site 512565002977 GTP/Mg2+ binding site [chemical binding]; other site 512565002978 Switch I region; other site 512565002979 G2 box; other site 512565002980 G3 box; other site 512565002981 Switch II region; other site 512565002982 G4 box; other site 512565002983 G5 box; other site 512565002984 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 512565002985 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 512565002986 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 512565002987 PAS domain S-box; Region: sensory_box; TIGR00229 512565002988 PAS domain; Region: PAS; smart00091 512565002989 putative active site [active] 512565002990 heme pocket [chemical binding]; other site 512565002991 enoyl-CoA hydratase; Provisional; Region: PRK07827 512565002992 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565002993 substrate binding site [chemical binding]; other site 512565002994 oxyanion hole (OAH) forming residues; other site 512565002995 trimer interface [polypeptide binding]; other site 512565002996 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 512565002997 coproporphyrinogen III oxidase; Validated; Region: PRK05628 512565002998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565002999 FeS/SAM binding site; other site 512565003000 Tic20-like protein; Region: Tic20; pfam09685 512565003001 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 512565003002 HTH domain; Region: HTH_11; cl17392 512565003003 chaperone protein DnaJ; Provisional; Region: PRK14278 512565003004 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 512565003005 HSP70 interaction site [polypeptide binding]; other site 512565003006 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 512565003007 Zn binding sites [ion binding]; other site 512565003008 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 512565003009 dimer interface [polypeptide binding]; other site 512565003010 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 512565003011 RNA methyltransferase, RsmE family; Region: TIGR00046 512565003012 Transposase domain (DUF772); Region: DUF772; pfam05598 512565003013 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 512565003014 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565003015 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565003016 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 512565003017 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565003018 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 512565003019 nucleotide binding site/active site [active] 512565003020 HIT family signature motif; other site 512565003021 catalytic residue [active] 512565003022 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565003023 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565003024 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 512565003025 PhoH-like protein; Region: PhoH; pfam02562 512565003026 metal-binding heat shock protein; Provisional; Region: PRK00016 512565003027 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512565003028 Domain of unknown function DUF21; Region: DUF21; pfam01595 512565003029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512565003030 Transporter associated domain; Region: CorC_HlyC; smart01091 512565003031 GTPase Era; Reviewed; Region: era; PRK00089 512565003032 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 512565003033 G1 box; other site 512565003034 GTP/Mg2+ binding site [chemical binding]; other site 512565003035 Switch I region; other site 512565003036 G2 box; other site 512565003037 Switch II region; other site 512565003038 G3 box; other site 512565003039 G4 box; other site 512565003040 G5 box; other site 512565003041 KH domain; Region: KH_2; pfam07650 512565003042 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 512565003043 Recombination protein O N terminal; Region: RecO_N; pfam11967 512565003044 Recombination protein O C terminal; Region: RecO_C; pfam02565 512565003045 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 512565003046 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 512565003047 catalytic residue [active] 512565003048 putative FPP diphosphate binding site; other site 512565003049 putative FPP binding hydrophobic cleft; other site 512565003050 dimer interface [polypeptide binding]; other site 512565003051 putative IPP diphosphate binding site; other site 512565003052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565003053 catalytic core [active] 512565003054 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 512565003055 Domain of unknown function DUF77; Region: DUF77; pfam01910 512565003056 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 512565003057 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 512565003058 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 512565003059 active site 512565003060 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565003061 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 512565003062 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512565003063 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512565003064 Walker A/P-loop; other site 512565003065 ATP binding site [chemical binding]; other site 512565003066 Q-loop/lid; other site 512565003067 ABC transporter signature motif; other site 512565003068 Walker B; other site 512565003069 D-loop; other site 512565003070 H-loop/switch region; other site 512565003071 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512565003072 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 512565003073 Walker A/P-loop; other site 512565003074 ATP binding site [chemical binding]; other site 512565003075 Q-loop/lid; other site 512565003076 ABC transporter signature motif; other site 512565003077 Walker B; other site 512565003078 D-loop; other site 512565003079 H-loop/switch region; other site 512565003080 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 512565003081 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565003082 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 512565003083 metal binding site 2 [ion binding]; metal-binding site 512565003084 putative DNA binding helix; other site 512565003085 metal binding site 1 [ion binding]; metal-binding site 512565003086 dimer interface [polypeptide binding]; other site 512565003087 structural Zn2+ binding site [ion binding]; other site 512565003088 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565003089 dimerization interface [polypeptide binding]; other site 512565003090 putative DNA binding site [nucleotide binding]; other site 512565003091 putative Zn2+ binding site [ion binding]; other site 512565003092 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512565003093 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565003094 ABC-ATPase subunit interface; other site 512565003095 dimer interface [polypeptide binding]; other site 512565003096 putative PBP binding regions; other site 512565003097 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 512565003098 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 512565003099 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565003100 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 512565003101 intersubunit interface [polypeptide binding]; other site 512565003102 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 512565003103 glycyl-tRNA synthetase; Provisional; Region: PRK04173 512565003104 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565003105 motif 1; other site 512565003106 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 512565003107 active site 512565003108 motif 2; other site 512565003109 motif 3; other site 512565003110 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 512565003111 anticodon binding site; other site 512565003112 XdhC Rossmann domain; Region: XdhC_C; pfam13478 512565003113 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 512565003114 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 512565003115 FMN binding site [chemical binding]; other site 512565003116 active site 512565003117 catalytic residues [active] 512565003118 substrate binding site [chemical binding]; other site 512565003119 Histidine kinase; Region: HisKA_3; pfam07730 512565003120 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565003121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565003122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565003123 active site 512565003124 phosphorylation site [posttranslational modification] 512565003125 intermolecular recognition site; other site 512565003126 dimerization interface [polypeptide binding]; other site 512565003127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565003128 DNA binding residues [nucleotide binding] 512565003129 dimerization interface [polypeptide binding]; other site 512565003130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565003131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565003132 Protein of unknown function (DUF713); Region: DUF713; pfam05218 512565003133 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 512565003134 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 512565003135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565003136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565003137 active site 512565003138 metal binding site [ion binding]; metal-binding site 512565003139 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 512565003140 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565003141 Zn2+ binding site [ion binding]; other site 512565003142 Mg2+ binding site [ion binding]; other site 512565003143 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 512565003144 DNA primase; Validated; Region: dnaG; PRK05667 512565003145 CHC2 zinc finger; Region: zf-CHC2; pfam01807 512565003146 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 512565003147 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 512565003148 active site 512565003149 metal binding site [ion binding]; metal-binding site 512565003150 interdomain interaction site; other site 512565003151 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 512565003152 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 512565003153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565003154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565003155 Walker A/P-loop; other site 512565003156 ATP binding site [chemical binding]; other site 512565003157 Q-loop/lid; other site 512565003158 ABC transporter signature motif; other site 512565003159 Walker B; other site 512565003160 D-loop; other site 512565003161 H-loop/switch region; other site 512565003162 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565003163 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565003164 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565003165 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 512565003166 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565003167 dimerization interface [polypeptide binding]; other site 512565003168 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 512565003169 putative Zn2+ binding site [ion binding]; other site 512565003170 putative DNA binding site [nucleotide binding]; other site 512565003171 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565003172 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565003173 nucleotide binding site [chemical binding]; other site 512565003174 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 512565003175 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565003176 Walker A/P-loop; other site 512565003177 ATP binding site [chemical binding]; other site 512565003178 Q-loop/lid; other site 512565003179 ABC transporter signature motif; other site 512565003180 Walker B; other site 512565003181 D-loop; other site 512565003182 H-loop/switch region; other site 512565003183 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512565003184 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565003185 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565003186 TM-ABC transporter signature motif; other site 512565003187 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 512565003188 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565003189 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565003190 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565003191 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512565003192 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565003193 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565003194 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 512565003195 Metal-binding active site; metal-binding site 512565003196 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 512565003197 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 512565003198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565003199 TrkA-C domain; Region: TrkA_C; pfam02080 512565003200 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 512565003201 amphipathic channel; other site 512565003202 Asn-Pro-Ala signature motifs; other site 512565003203 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 512565003204 N-acetyl-D-glucosamine binding site [chemical binding]; other site 512565003205 catalytic residue [active] 512565003206 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 512565003207 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565003208 putative active site [active] 512565003209 Domain of unknown function DUF87; Region: DUF87; pfam01935 512565003210 AAA-like domain; Region: AAA_10; pfam12846 512565003211 Zonular occludens toxin (Zot); Region: Zot; cl17485 512565003212 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 512565003213 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565003214 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 512565003215 glycerol kinase; Provisional; Region: glpK; PRK00047 512565003216 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 512565003217 N- and C-terminal domain interface [polypeptide binding]; other site 512565003218 active site 512565003219 MgATP binding site [chemical binding]; other site 512565003220 catalytic site [active] 512565003221 metal binding site [ion binding]; metal-binding site 512565003222 glycerol binding site [chemical binding]; other site 512565003223 homotetramer interface [polypeptide binding]; other site 512565003224 homodimer interface [polypeptide binding]; other site 512565003225 FBP binding site [chemical binding]; other site 512565003226 protein IIAGlc interface [polypeptide binding]; other site 512565003227 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565003228 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 512565003229 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565003230 glycerol kinase; Provisional; Region: glpK; PRK00047 512565003231 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565003232 nucleotide binding site [chemical binding]; other site 512565003233 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 512565003234 Zn binding site [ion binding]; other site 512565003235 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 512565003236 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 512565003237 Putative esterase; Region: Esterase; pfam00756 512565003238 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565003239 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 512565003240 NodB motif; other site 512565003241 putative active site [active] 512565003242 putative catalytic site [active] 512565003243 putative Zn binding site [ion binding]; other site 512565003244 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565003245 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 512565003246 DXD motif; other site 512565003247 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 512565003248 active site 512565003249 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512565003250 active site 512565003251 catalytic triad [active] 512565003252 oxyanion hole [active] 512565003253 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565003254 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565003255 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565003256 AAA-like domain; Region: AAA_10; pfam12846 512565003257 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 512565003258 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565003259 Walker A motif; other site 512565003260 ATP binding site [chemical binding]; other site 512565003261 Walker B motif; other site 512565003262 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 512565003263 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 512565003264 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512565003265 Zeta toxin; Region: Zeta_toxin; pfam06414 512565003266 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565003267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565003268 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 512565003269 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 512565003270 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 512565003271 active site 512565003272 HIGH motif; other site 512565003273 KMSK motif region; other site 512565003274 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 512565003275 tRNA binding surface [nucleotide binding]; other site 512565003276 anticodon binding site; other site 512565003277 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 512565003278 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 512565003279 active site 512565003280 metal binding site [ion binding]; metal-binding site 512565003281 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 512565003282 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565003283 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565003284 active site 512565003285 ATP binding site [chemical binding]; other site 512565003286 substrate binding site [chemical binding]; other site 512565003287 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565003288 substrate binding site [chemical binding]; other site 512565003289 activation loop (A-loop); other site 512565003290 activation loop (A-loop); other site 512565003291 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565003292 anti sigma factor interaction site; other site 512565003293 regulatory phosphorylation site [posttranslational modification]; other site 512565003294 Survival protein SurE; Region: SurE; cl00448 512565003295 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565003296 substrate binding site [chemical binding]; other site 512565003297 ATP binding site [chemical binding]; other site 512565003298 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 512565003299 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 512565003300 Family description; Region: UvrD_C_2; pfam13538 512565003301 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565003302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565003303 Serine hydrolase; Region: Ser_hydrolase; cl17834 512565003304 TAP-like protein; Region: Abhydrolase_4; pfam08386 512565003305 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 512565003306 active site clefts [active] 512565003307 zinc binding site [ion binding]; other site 512565003308 dimer interface [polypeptide binding]; other site 512565003309 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 512565003310 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565003311 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565003312 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 512565003313 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 512565003314 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 512565003315 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 512565003316 dimer interface [polypeptide binding]; other site 512565003317 active site 512565003318 acyl carrier protein; Provisional; Region: acpP; PRK00982 512565003319 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 512565003320 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 512565003321 dimer interface [polypeptide binding]; other site 512565003322 active site 512565003323 CoA binding pocket [chemical binding]; other site 512565003324 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 512565003325 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 512565003326 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 512565003327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565003328 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 512565003329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565003330 active site 512565003331 HIGH motif; other site 512565003332 nucleotide binding site [chemical binding]; other site 512565003333 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 512565003334 active site 512565003335 KMSKS motif; other site 512565003336 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565003337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565003338 dimer interface [polypeptide binding]; other site 512565003339 putative CheW interface [polypeptide binding]; other site 512565003340 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 512565003341 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 512565003342 dimer interface [polypeptide binding]; other site 512565003343 TPP-binding site [chemical binding]; other site 512565003344 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 512565003345 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 512565003346 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 512565003347 PYR/PP interface [polypeptide binding]; other site 512565003348 dimer interface [polypeptide binding]; other site 512565003349 TPP binding site [chemical binding]; other site 512565003350 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565003351 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 512565003352 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 512565003353 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 512565003354 dimer interface [polypeptide binding]; other site 512565003355 catalytic triad [active] 512565003356 Protein of unknown function (DUF402); Region: DUF402; cl00979 512565003357 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 512565003358 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565003359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565003360 non-specific DNA binding site [nucleotide binding]; other site 512565003361 salt bridge; other site 512565003362 sequence-specific DNA binding site [nucleotide binding]; other site 512565003363 Flavoprotein; Region: Flavoprotein; pfam02441 512565003364 Uncharacterized conserved protein [Function unknown]; Region: COG0327 512565003365 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 512565003366 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 512565003367 Putative zinc ribbon domain; Region: DUF164; pfam02591 512565003368 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 512565003369 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 512565003370 RNA/DNA hybrid binding site [nucleotide binding]; other site 512565003371 active site 512565003372 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565003373 catalytic core [active] 512565003374 Glyco_18 domain; Region: Glyco_18; smart00636 512565003375 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 512565003376 active site 512565003377 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 512565003378 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 512565003379 Na binding site [ion binding]; other site 512565003380 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 512565003381 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 512565003382 dimerization interface [polypeptide binding]; other site 512565003383 active site 512565003384 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 512565003385 threonine dehydratase; Provisional; Region: PRK08246 512565003386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565003387 catalytic residue [active] 512565003388 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 512565003389 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 512565003390 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 512565003391 TIR domain; Region: TIR_2; pfam13676 512565003392 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512565003393 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512565003394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565003395 S-adenosylmethionine binding site [chemical binding]; other site 512565003396 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 512565003397 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 512565003398 RNB domain; Region: RNB; pfam00773 512565003399 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 512565003400 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 512565003401 oligomerization interface [polypeptide binding]; other site 512565003402 active site 512565003403 metal binding site [ion binding]; metal-binding site 512565003404 NAD synthetase; Provisional; Region: PRK13981 512565003405 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 512565003406 multimer interface [polypeptide binding]; other site 512565003407 active site 512565003408 catalytic triad [active] 512565003409 protein interface 1 [polypeptide binding]; other site 512565003410 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 512565003411 homodimer interface [polypeptide binding]; other site 512565003412 NAD binding pocket [chemical binding]; other site 512565003413 ATP binding pocket [chemical binding]; other site 512565003414 Mg binding site [ion binding]; other site 512565003415 active-site loop [active] 512565003416 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 512565003417 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 512565003418 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 512565003419 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565003420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565003421 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565003422 DNA binding residues [nucleotide binding] 512565003423 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 512565003424 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 512565003425 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565003426 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565003427 NAD(P) binding site [chemical binding]; other site 512565003428 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 512565003429 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 512565003430 catalytic triad [active] 512565003431 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 512565003432 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 512565003433 metal binding triad; other site 512565003434 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 512565003435 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 512565003436 metal binding triad; other site 512565003437 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 512565003438 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565003439 MarR family; Region: MarR; pfam01047 512565003440 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 512565003441 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 512565003442 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 512565003443 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 512565003444 putative active site [active] 512565003445 glutamine synthetase, type I; Region: GlnA; TIGR00653 512565003446 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 512565003447 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 512565003448 RDD family; Region: RDD; pfam06271 512565003449 Proteins of 100 residues with WXG; Region: WXG100; cl02005 512565003450 Proteins of 100 residues with WXG; Region: WXG100; cl02005 512565003451 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 512565003452 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565003453 catalytic residues [active] 512565003454 Protein of unknown function (DUF690); Region: DUF690; cl04939 512565003455 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 512565003456 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 512565003457 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565003458 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 512565003459 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565003460 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565003461 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 512565003462 Right handed beta helix region; Region: Beta_helix; pfam13229 512565003463 stage V sporulation protein K; Region: spore_V_K; TIGR02881 512565003464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565003465 Walker A motif; other site 512565003466 ATP binding site [chemical binding]; other site 512565003467 Walker B motif; other site 512565003468 arginine finger; other site 512565003469 The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase; Region: Cdt1_c; cd08767 512565003470 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 512565003471 AAA ATPase domain; Region: AAA_16; pfam13191 512565003472 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565003473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565003474 DNA binding residues [nucleotide binding] 512565003475 dimerization interface [polypeptide binding]; other site 512565003476 lipoyl synthase; Provisional; Region: PRK05481 512565003477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565003478 FeS/SAM binding site; other site 512565003479 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 512565003480 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 512565003481 Dimer interface [polypeptide binding]; other site 512565003482 anticodon binding site; other site 512565003483 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565003484 motif 1; other site 512565003485 dimer interface [polypeptide binding]; other site 512565003486 active site 512565003487 motif 2; other site 512565003488 motif 3; other site 512565003489 Predicted membrane protein [General function prediction only]; Region: COG4194 512565003490 lipoate-protein ligase B; Provisional; Region: PRK14345 512565003491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565003492 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 512565003493 NAD(P) binding site [chemical binding]; other site 512565003494 active site 512565003495 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 512565003496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 512565003497 E3 interaction surface; other site 512565003498 lipoyl attachment site [posttranslational modification]; other site 512565003499 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 512565003500 E3 interaction surface; other site 512565003501 lipoyl attachment site [posttranslational modification]; other site 512565003502 e3 binding domain; Region: E3_binding; pfam02817 512565003503 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 512565003504 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 512565003505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565003506 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565003507 multifunctional aminopeptidase A; Provisional; Region: PRK00913 512565003508 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 512565003509 interface (dimer of trimers) [polypeptide binding]; other site 512565003510 Substrate-binding/catalytic site; other site 512565003511 Zn-binding sites [ion binding]; other site 512565003512 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 512565003513 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 512565003514 cobalamin synthase; Reviewed; Region: cobS; PRK00235 512565003515 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 512565003516 homotrimer interface [polypeptide binding]; other site 512565003517 Walker A motif; other site 512565003518 GTP binding site [chemical binding]; other site 512565003519 Walker B motif; other site 512565003520 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 512565003521 putative cataytic base [active] 512565003522 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 512565003523 Peptidase family M50; Region: Peptidase_M50; pfam02163 512565003524 active site 512565003525 putative substrate binding region [chemical binding]; other site 512565003526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565003527 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565003528 active site 512565003529 catalytic tetrad [active] 512565003530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565003531 TPR motif; other site 512565003532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565003533 binding surface 512565003534 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 512565003535 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 512565003536 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 512565003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565003538 Walker A/P-loop; other site 512565003539 ATP binding site [chemical binding]; other site 512565003540 Q-loop/lid; other site 512565003541 ABC transporter signature motif; other site 512565003542 Walker B; other site 512565003543 D-loop; other site 512565003544 H-loop/switch region; other site 512565003545 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565003546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565003547 non-specific DNA binding site [nucleotide binding]; other site 512565003548 salt bridge; other site 512565003549 sequence-specific DNA binding site [nucleotide binding]; other site 512565003550 Cupin domain; Region: Cupin_2; cl17218 512565003551 AzlC protein; Region: AzlC; pfam03591 512565003552 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 512565003553 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 512565003554 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 512565003555 hinge; other site 512565003556 active site 512565003557 quinolinate synthetase; Provisional; Region: PRK09375 512565003558 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 512565003559 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 512565003560 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 512565003561 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565003562 substrate binding site [chemical binding]; other site 512565003563 ATP binding site [chemical binding]; other site 512565003564 AAA domain; Region: AAA_33; pfam13671 512565003565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512565003566 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 512565003567 CPxP motif; other site 512565003568 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565003569 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 512565003570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565003571 catalytic residue [active] 512565003572 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 512565003573 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 512565003574 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 512565003575 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 512565003576 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 512565003577 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 512565003578 FAD binding domain; Region: FAD_binding_3; pfam01494 512565003579 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 512565003580 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 512565003581 Subunit I/III interface [polypeptide binding]; other site 512565003582 Cytochrome c; Region: Cytochrom_C; cl11414 512565003583 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 512565003584 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 512565003585 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 512565003586 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 512565003587 iron-sulfur cluster [ion binding]; other site 512565003588 [2Fe-2S] cluster binding site [ion binding]; other site 512565003589 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 512565003590 heme bH binding site [chemical binding]; other site 512565003591 intrachain domain interface; other site 512565003592 heme bL binding site [chemical binding]; other site 512565003593 interchain domain interface [polypeptide binding]; other site 512565003594 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 512565003595 Qo binding site; other site 512565003596 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565003597 AsnC family; Region: AsnC_trans_reg; pfam01037 512565003598 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 512565003599 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512565003600 active site 512565003601 NUDIX domain; Region: NUDIX; pfam00293 512565003602 nudix motif; other site 512565003603 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 512565003604 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565003605 Zn2+ binding site [ion binding]; other site 512565003606 Mg2+ binding site [ion binding]; other site 512565003607 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 512565003608 synthetase active site [active] 512565003609 NTP binding site [chemical binding]; other site 512565003610 metal binding site [ion binding]; metal-binding site 512565003611 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 512565003612 hypothetical protein; Validated; Region: PRK07883 512565003613 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 512565003614 active site 512565003615 catalytic site [active] 512565003616 substrate binding site [chemical binding]; other site 512565003617 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 512565003618 GIY-YIG motif/motif A; other site 512565003619 active site 512565003620 catalytic site [active] 512565003621 putative DNA binding site [nucleotide binding]; other site 512565003622 metal binding site [ion binding]; metal-binding site 512565003623 YacP-like NYN domain; Region: NYN_YacP; cl01491 512565003624 Peptidase family M48; Region: Peptidase_M48; cl12018 512565003625 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565003626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565003627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565003628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565003629 Walker A/P-loop; other site 512565003630 ATP binding site [chemical binding]; other site 512565003631 Q-loop/lid; other site 512565003632 ABC transporter signature motif; other site 512565003633 Walker B; other site 512565003634 D-loop; other site 512565003635 H-loop/switch region; other site 512565003636 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512565003637 catalytic residues [active] 512565003638 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565003639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565003640 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565003641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565003642 putative Zn2+ binding site [ion binding]; other site 512565003643 putative DNA binding site [nucleotide binding]; other site 512565003644 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565003645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565003646 active site 512565003647 phosphorylation site [posttranslational modification] 512565003648 intermolecular recognition site; other site 512565003649 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565003650 DNA binding residues [nucleotide binding] 512565003651 dimerization interface [polypeptide binding]; other site 512565003652 GAF domain; Region: GAF_3; pfam13492 512565003653 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565003654 Histidine kinase; Region: HisKA_3; pfam07730 512565003655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565003656 ATP binding site [chemical binding]; other site 512565003657 Mg2+ binding site [ion binding]; other site 512565003658 G-X-G motif; other site 512565003659 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 512565003660 putative hydrophobic ligand binding site [chemical binding]; other site 512565003661 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 512565003662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565003663 nucleotide binding site [chemical binding]; other site 512565003664 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565003665 putative metal binding site [ion binding]; other site 512565003666 putative catalytic site [active] 512565003667 putative phosphate binding site [ion binding]; other site 512565003668 putative metal binding site [ion binding]; other site 512565003669 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565003670 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 512565003671 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565003672 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 512565003673 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 512565003674 active site 512565003675 homotetramer interface [polypeptide binding]; other site 512565003676 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565003677 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565003678 putative acyl-acceptor binding pocket; other site 512565003679 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565003680 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565003681 ligand binding site [chemical binding]; other site 512565003682 flexible hinge region; other site 512565003683 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 512565003684 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 512565003685 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565003686 ATP binding site [chemical binding]; other site 512565003687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565003688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565003689 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565003690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565003691 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 512565003692 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565003693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565003694 putative substrate translocation pore; other site 512565003695 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565003696 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565003697 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565003698 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565003699 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565003700 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 512565003701 phosphofructokinase; Region: PFK_mixed; TIGR02483 512565003702 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 512565003703 active site 512565003704 ADP/pyrophosphate binding site [chemical binding]; other site 512565003705 dimerization interface [polypeptide binding]; other site 512565003706 allosteric effector site; other site 512565003707 fructose-1,6-bisphosphate binding site; other site 512565003708 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 512565003709 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 512565003710 Uncharacterized conserved protein [Function unknown]; Region: COG3375 512565003711 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 512565003712 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 512565003713 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565003714 Protein of unknown function (DUF429); Region: DUF429; pfam04250 512565003715 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 512565003716 aromatic chitin/cellulose binding site residues [chemical binding]; other site 512565003717 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 512565003718 Glyco_18 domain; Region: Glyco_18; smart00636 512565003719 active site 512565003720 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 512565003721 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565003722 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 512565003723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565003724 catalytic residue [active] 512565003725 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512565003726 Glutamine amidotransferase class-I; Region: GATase; pfam00117 512565003727 conserved cys residue [active] 512565003728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565003729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565003730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565003731 dimerization interface [polypeptide binding]; other site 512565003732 AP endonuclease family 2; Region: AP2Ec; smart00518 512565003733 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 512565003734 AP (apurinic/apyrimidinic) site pocket; other site 512565003735 DNA interaction; other site 512565003736 Metal-binding active site; metal-binding site 512565003737 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565003738 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565003739 active site 512565003740 ATP binding site [chemical binding]; other site 512565003741 substrate binding site [chemical binding]; other site 512565003742 activation loop (A-loop); other site 512565003743 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565003744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 512565003745 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565003746 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565003747 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565003748 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565003749 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565003750 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 512565003751 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 512565003752 substrate binding pocket [chemical binding]; other site 512565003753 chain length determination region; other site 512565003754 substrate-Mg2+ binding site; other site 512565003755 catalytic residues [active] 512565003756 aspartate-rich region 1; other site 512565003757 active site lid residues [active] 512565003758 aspartate-rich region 2; other site 512565003759 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 512565003760 FAD binding site [chemical binding]; other site 512565003761 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 512565003762 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 512565003763 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 512565003764 active site 512565003765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565003766 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 512565003767 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565003768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565003769 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 512565003770 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 512565003771 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 512565003772 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 512565003773 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 512565003774 L-aspartate oxidase; Provisional; Region: PRK06175 512565003775 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 512565003776 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 512565003777 proximal heme binding site [chemical binding]; other site 512565003778 distal heme binding site [chemical binding]; other site 512565003779 putative dimer interface [polypeptide binding]; other site 512565003780 putative Iron-sulfur protein interface [polypeptide binding]; other site 512565003781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565003782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565003783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512565003784 dimerization interface [polypeptide binding]; other site 512565003785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565003786 S-adenosylmethionine binding site [chemical binding]; other site 512565003787 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 512565003788 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565003789 metal ion-dependent adhesion site (MIDAS); other site 512565003790 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565003791 phytoene desaturase; Region: crtI_fam; TIGR02734 512565003792 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 512565003793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512565003794 active site 512565003795 Protein of unknown function (DUF422); Region: DUF422; cl00991 512565003796 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565003797 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 512565003798 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 512565003799 putative deacylase active site [active] 512565003800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565003801 NAD(P) binding site [chemical binding]; other site 512565003802 active site 512565003803 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565003804 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565003805 dimerization interface [polypeptide binding]; other site 512565003806 putative DNA binding site [nucleotide binding]; other site 512565003807 putative Zn2+ binding site [ion binding]; other site 512565003808 DNA Polymerase Y-family; Region: PolY_like; cd03468 512565003809 active site 512565003810 DNA binding site [nucleotide binding] 512565003811 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 512565003812 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512565003813 active site 512565003814 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 512565003815 generic binding surface II; other site 512565003816 generic binding surface I; other site 512565003817 Subtilisin inhibitor-like; Region: SSI; cl11594 512565003818 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 512565003819 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 512565003820 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 512565003821 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 512565003822 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 512565003823 Protein of unknown function DUF58; Region: DUF58; pfam01882 512565003824 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565003825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565003826 Walker A motif; other site 512565003827 ATP binding site [chemical binding]; other site 512565003828 Walker B motif; other site 512565003829 arginine finger; other site 512565003830 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 512565003831 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 512565003832 HIGH motif; other site 512565003833 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 512565003834 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565003835 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565003836 active site 512565003837 KMSKS motif; other site 512565003838 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 512565003839 tRNA binding surface [nucleotide binding]; other site 512565003840 Uncharacterized conserved protein [Function unknown]; Region: COG0398 512565003841 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565003842 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 512565003843 catalytic triad [active] 512565003844 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565003845 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 512565003846 NlpC/P60 family; Region: NLPC_P60; cl17555 512565003847 cell division protein MraZ; Reviewed; Region: PRK00326 512565003848 MraZ protein; Region: MraZ; pfam02381 512565003849 MraZ protein; Region: MraZ; pfam02381 512565003850 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 512565003851 MraW methylase family; Region: Methyltransf_5; cl17771 512565003852 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 512565003853 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 512565003854 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 512565003855 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 512565003856 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 512565003857 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565003858 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512565003859 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 512565003860 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 512565003861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565003862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512565003863 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 512565003864 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 512565003865 Mg++ binding site [ion binding]; other site 512565003866 putative catalytic motif [active] 512565003867 putative substrate binding site [chemical binding]; other site 512565003868 cell division protein FtsW; Region: ftsW; TIGR02614 512565003869 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 512565003870 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 512565003871 active site 512565003872 homodimer interface [polypeptide binding]; other site 512565003873 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 512565003874 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 512565003875 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565003876 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512565003877 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 512565003878 Cell division protein FtsQ; Region: FtsQ; pfam03799 512565003879 cell division protein FtsZ; Validated; Region: PRK09330 512565003880 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 512565003881 nucleotide binding site [chemical binding]; other site 512565003882 SulA interaction site; other site 512565003883 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 512565003884 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565003885 catalytic residue [active] 512565003886 Protein of unknown function (DUF552); Region: DUF552; pfam04472 512565003887 YGGT family; Region: YGGT; pfam02325 512565003888 DivIVA protein; Region: DivIVA; pfam05103 512565003889 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565003890 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 512565003891 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 512565003892 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 512565003893 lipoprotein signal peptidase; Provisional; Region: PRK14764 512565003894 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 512565003895 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512565003896 RNA binding surface [nucleotide binding]; other site 512565003897 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 512565003898 active site 512565003899 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 512565003900 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565003901 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 512565003902 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 512565003903 active site 512565003904 PHP Thumb interface [polypeptide binding]; other site 512565003905 metal binding site [ion binding]; metal-binding site 512565003906 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 512565003907 generic binding surface II; other site 512565003908 generic binding surface I; other site 512565003909 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 512565003910 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 512565003911 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 512565003912 NAD binding site [chemical binding]; other site 512565003913 dimerization interface [polypeptide binding]; other site 512565003914 product binding site; other site 512565003915 substrate binding site [chemical binding]; other site 512565003916 zinc binding site [ion binding]; other site 512565003917 catalytic residues [active] 512565003918 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 512565003919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565003920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565003921 homodimer interface [polypeptide binding]; other site 512565003922 catalytic residue [active] 512565003923 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 512565003924 putative active site pocket [active] 512565003925 4-fold oligomerization interface [polypeptide binding]; other site 512565003926 metal binding residues [ion binding]; metal-binding site 512565003927 3-fold/trimer interface [polypeptide binding]; other site 512565003928 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 512565003929 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 512565003930 putative active site [active] 512565003931 oxyanion strand; other site 512565003932 catalytic triad [active] 512565003933 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 512565003934 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 512565003935 catalytic residues [active] 512565003936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565003937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565003938 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 512565003939 putative dimerization interface [polypeptide binding]; other site 512565003940 EamA-like transporter family; Region: EamA; pfam00892 512565003941 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 512565003942 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 512565003943 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 512565003944 substrate binding site [chemical binding]; other site 512565003945 glutamase interaction surface [polypeptide binding]; other site 512565003946 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512565003947 Predicted membrane protein [Function unknown]; Region: COG2364 512565003948 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 512565003949 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565003950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565003951 homodimer interface [polypeptide binding]; other site 512565003952 catalytic residue [active] 512565003953 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 512565003954 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 512565003955 acyl-activating enzyme (AAE) consensus motif; other site 512565003956 putative AMP binding site [chemical binding]; other site 512565003957 putative active site [active] 512565003958 putative CoA binding site [chemical binding]; other site 512565003959 TIGR03085 family protein; Region: TIGR03085 512565003960 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565003961 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565003962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565003963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565003964 Walker A/P-loop; other site 512565003965 ATP binding site [chemical binding]; other site 512565003966 Q-loop/lid; other site 512565003967 ABC transporter signature motif; other site 512565003968 Walker B; other site 512565003969 D-loop; other site 512565003970 H-loop/switch region; other site 512565003971 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565003972 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565003973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565003974 Walker A/P-loop; other site 512565003975 ATP binding site [chemical binding]; other site 512565003976 Q-loop/lid; other site 512565003977 ABC transporter signature motif; other site 512565003978 Walker B; other site 512565003979 D-loop; other site 512565003980 H-loop/switch region; other site 512565003981 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 512565003982 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 512565003983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512565003984 RNA binding surface [nucleotide binding]; other site 512565003985 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 512565003986 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 512565003987 anthranilate synthase component I; Provisional; Region: PRK13571 512565003988 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 512565003989 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 512565003990 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 512565003991 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 512565003992 active site 512565003993 ribulose/triose binding site [chemical binding]; other site 512565003994 phosphate binding site [ion binding]; other site 512565003995 substrate (anthranilate) binding pocket [chemical binding]; other site 512565003996 product (indole) binding pocket [chemical binding]; other site 512565003997 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 512565003998 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 512565003999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565004000 catalytic residue [active] 512565004001 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 512565004002 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 512565004003 substrate binding site [chemical binding]; other site 512565004004 active site 512565004005 catalytic residues [active] 512565004006 heterodimer interface [polypeptide binding]; other site 512565004007 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 512565004008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 512565004009 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 512565004010 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 512565004011 active site 512565004012 dimer interface [polypeptide binding]; other site 512565004013 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 512565004014 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 512565004015 active site 512565004016 FMN binding site [chemical binding]; other site 512565004017 substrate binding site [chemical binding]; other site 512565004018 3Fe-4S cluster binding site [ion binding]; other site 512565004019 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 512565004020 domain interface; other site 512565004021 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 512565004022 pyruvate kinase; Provisional; Region: PRK06247 512565004023 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 512565004024 domain interfaces; other site 512565004025 active site 512565004026 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 512565004027 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 512565004028 active site 512565004029 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 512565004030 catalytic triad [active] 512565004031 dimer interface [polypeptide binding]; other site 512565004032 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 512565004033 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 512565004034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004035 active site 512565004036 phosphorylation site [posttranslational modification] 512565004037 intermolecular recognition site; other site 512565004038 dimerization interface [polypeptide binding]; other site 512565004039 ANTAR domain; Region: ANTAR; pfam03861 512565004040 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 512565004041 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512565004042 TM-ABC transporter signature motif; other site 512565004043 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565004044 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 512565004045 TM-ABC transporter signature motif; other site 512565004046 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565004047 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512565004048 Walker A/P-loop; other site 512565004049 ATP binding site [chemical binding]; other site 512565004050 Q-loop/lid; other site 512565004051 ABC transporter signature motif; other site 512565004052 Walker B; other site 512565004053 D-loop; other site 512565004054 H-loop/switch region; other site 512565004055 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565004056 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512565004057 Walker A/P-loop; other site 512565004058 ATP binding site [chemical binding]; other site 512565004059 Q-loop/lid; other site 512565004060 ABC transporter signature motif; other site 512565004061 Walker B; other site 512565004062 D-loop; other site 512565004063 H-loop/switch region; other site 512565004064 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 512565004065 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 512565004066 ligand binding site [chemical binding]; other site 512565004067 DNA polymerase I; Provisional; Region: PRK05755 512565004068 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 512565004069 active site 512565004070 metal binding site 1 [ion binding]; metal-binding site 512565004071 putative 5' ssDNA interaction site; other site 512565004072 metal binding site 3; metal-binding site 512565004073 metal binding site 2 [ion binding]; metal-binding site 512565004074 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 512565004075 putative DNA binding site [nucleotide binding]; other site 512565004076 putative metal binding site [ion binding]; other site 512565004077 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 512565004078 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 512565004079 active site 512565004080 DNA binding site [nucleotide binding] 512565004081 catalytic site [active] 512565004082 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565004083 dimerization interface [polypeptide binding]; other site 512565004084 putative DNA binding site [nucleotide binding]; other site 512565004085 putative Zn2+ binding site [ion binding]; other site 512565004086 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 512565004087 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 512565004088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565004089 S-adenosylmethionine binding site [chemical binding]; other site 512565004090 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 512565004091 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 512565004092 RNA binding site [nucleotide binding]; other site 512565004093 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 512565004094 RNA binding site [nucleotide binding]; other site 512565004095 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 512565004096 RNA binding site [nucleotide binding]; other site 512565004097 S1 RNA binding domain; Region: S1; pfam00575 512565004098 RNA binding site [nucleotide binding]; other site 512565004099 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 512565004100 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 512565004101 CoA-binding site [chemical binding]; other site 512565004102 ATP-binding [chemical binding]; other site 512565004103 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 512565004104 excinuclease ABC subunit B; Provisional; Region: PRK05298 512565004105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565004106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565004107 nucleotide binding region [chemical binding]; other site 512565004108 ATP-binding site [chemical binding]; other site 512565004109 Ultra-violet resistance protein B; Region: UvrB; pfam12344 512565004110 UvrB/uvrC motif; Region: UVR; pfam02151 512565004111 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 512565004112 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 512565004113 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 512565004114 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 512565004115 G1 box; other site 512565004116 putative GEF interaction site [polypeptide binding]; other site 512565004117 GTP/Mg2+ binding site [chemical binding]; other site 512565004118 Switch I region; other site 512565004119 G2 box; other site 512565004120 G3 box; other site 512565004121 Switch II region; other site 512565004122 G4 box; other site 512565004123 G5 box; other site 512565004124 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 512565004125 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 512565004126 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 512565004127 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 512565004128 N-acetyl-D-glucosamine binding site [chemical binding]; other site 512565004129 catalytic residue [active] 512565004130 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 512565004131 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 512565004132 23S rRNA interface [nucleotide binding]; other site 512565004133 L7/L12 interface [polypeptide binding]; other site 512565004134 putative thiostrepton binding site; other site 512565004135 L25 interface [polypeptide binding]; other site 512565004136 Clp protease; Region: CLP_protease; pfam00574 512565004137 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 512565004138 active site 512565004139 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 512565004140 RNA polymerase factor sigma-70; Validated; Region: PRK09047 512565004141 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565004142 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565004143 DNA binding residues [nucleotide binding] 512565004144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565004145 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 512565004146 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565004147 Predicted GTPases [General function prediction only]; Region: COG1162 512565004148 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 512565004149 RNA binding site [nucleotide binding]; other site 512565004150 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 512565004151 GTPase/Zn-binding domain interface [polypeptide binding]; other site 512565004152 GTP/Mg2+ binding site [chemical binding]; other site 512565004153 G4 box; other site 512565004154 G5 box; other site 512565004155 G1 box; other site 512565004156 Switch I region; other site 512565004157 G2 box; other site 512565004158 G3 box; other site 512565004159 Switch II region; other site 512565004160 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 512565004161 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512565004162 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512565004163 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 512565004164 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 512565004165 iron-sulfur cluster [ion binding]; other site 512565004166 [2Fe-2S] cluster binding site [ion binding]; other site 512565004167 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 512565004168 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 512565004169 GIY-YIG motif/motif A; other site 512565004170 active site 512565004171 catalytic site [active] 512565004172 putative DNA binding site [nucleotide binding]; other site 512565004173 metal binding site [ion binding]; metal-binding site 512565004174 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 512565004175 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 512565004176 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 512565004177 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 512565004178 phosphate binding site [ion binding]; other site 512565004179 putative substrate binding pocket [chemical binding]; other site 512565004180 dimer interface [polypeptide binding]; other site 512565004181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 512565004182 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 512565004183 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 512565004184 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 512565004185 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 512565004186 Phosphoglycerate kinase; Region: PGK; pfam00162 512565004187 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 512565004188 substrate binding site [chemical binding]; other site 512565004189 hinge regions; other site 512565004190 ADP binding site [chemical binding]; other site 512565004191 catalytic site [active] 512565004192 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 512565004193 triosephosphate isomerase; Provisional; Region: PRK14565 512565004194 substrate binding site [chemical binding]; other site 512565004195 dimer interface [polypeptide binding]; other site 512565004196 catalytic triad [active] 512565004197 Preprotein translocase SecG subunit; Region: SecG; cl09123 512565004198 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 512565004199 putative acetyltransferase; Provisional; Region: PRK03624 512565004200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565004201 Coenzyme A binding pocket [chemical binding]; other site 512565004202 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 512565004203 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 512565004204 putative active site [active] 512565004205 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 512565004206 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 512565004207 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 512565004208 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 512565004209 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 512565004210 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 512565004211 putative active site [active] 512565004212 transaldolase; Provisional; Region: PRK03903 512565004213 catalytic residue [active] 512565004214 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 512565004215 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 512565004216 TPP-binding site [chemical binding]; other site 512565004217 dimer interface [polypeptide binding]; other site 512565004218 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512565004219 PYR/PP interface [polypeptide binding]; other site 512565004220 dimer interface [polypeptide binding]; other site 512565004221 TPP binding site [chemical binding]; other site 512565004222 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565004223 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 512565004224 UbiA prenyltransferase family; Region: UbiA; pfam01040 512565004225 Domain of unknown function (DUF362); Region: DUF362; pfam04015 512565004226 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565004227 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 512565004228 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 512565004229 Predicted transcriptional regulator [Transcription]; Region: COG2345 512565004230 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 512565004231 FeS assembly protein SufB; Region: sufB; TIGR01980 512565004232 FeS assembly protein SufD; Region: sufD; TIGR01981 512565004233 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 512565004234 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 512565004235 [2Fe-2S] cluster binding site [ion binding]; other site 512565004236 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 512565004237 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 512565004238 Walker A/P-loop; other site 512565004239 ATP binding site [chemical binding]; other site 512565004240 Q-loop/lid; other site 512565004241 ABC transporter signature motif; other site 512565004242 Walker B; other site 512565004243 D-loop; other site 512565004244 H-loop/switch region; other site 512565004245 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 512565004246 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 512565004247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565004248 catalytic residue [active] 512565004249 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 512565004250 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 512565004251 trimerization site [polypeptide binding]; other site 512565004252 active site 512565004253 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 512565004254 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565004255 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565004256 SCP-2 sterol transfer family; Region: SCP2; cl01225 512565004257 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565004258 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565004259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565004260 putative substrate translocation pore; other site 512565004261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565004262 catalytic core [active] 512565004263 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 512565004264 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 512565004265 active site 512565004266 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 512565004267 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512565004268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565004269 Walker A/P-loop; other site 512565004270 ATP binding site [chemical binding]; other site 512565004271 Q-loop/lid; other site 512565004272 ABC transporter signature motif; other site 512565004273 Walker B; other site 512565004274 D-loop; other site 512565004275 H-loop/switch region; other site 512565004276 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565004277 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565004278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565004279 substrate binding site [chemical binding]; other site 512565004280 oxyanion hole (OAH) forming residues; other site 512565004281 trimer interface [polypeptide binding]; other site 512565004282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565004283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565004284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565004285 Walker A/P-loop; other site 512565004286 ATP binding site [chemical binding]; other site 512565004287 Q-loop/lid; other site 512565004288 ABC transporter signature motif; other site 512565004289 Walker B; other site 512565004290 D-loop; other site 512565004291 H-loop/switch region; other site 512565004292 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 512565004293 active site 512565004294 SUMO-1 interface [polypeptide binding]; other site 512565004295 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 512565004296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565004297 NAD(P) binding site [chemical binding]; other site 512565004298 active site 512565004299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565004300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565004301 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 512565004302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565004303 motif II; other site 512565004304 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 512565004305 ATP binding site [chemical binding]; other site 512565004306 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 512565004307 aconitate hydratase; Validated; Region: PRK09277 512565004308 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 512565004309 substrate binding site [chemical binding]; other site 512565004310 ligand binding site [chemical binding]; other site 512565004311 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 512565004312 substrate binding site [chemical binding]; other site 512565004313 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512565004314 carbohydrate binding site [chemical binding]; other site 512565004315 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512565004316 carbohydrate binding site [chemical binding]; other site 512565004317 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 512565004318 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 512565004319 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 512565004320 Ca binding site [ion binding]; other site 512565004321 active site 512565004322 catalytic site [active] 512565004323 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 512565004324 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565004325 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565004326 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 512565004327 NB-ARC domain; Region: NB-ARC; pfam00931 512565004328 proline aminopeptidase P II; Provisional; Region: PRK10879 512565004329 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 512565004330 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 512565004331 active site 512565004332 E-class dimer interface [polypeptide binding]; other site 512565004333 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 512565004334 P-class dimer interface [polypeptide binding]; other site 512565004335 active site 512565004336 Cu2+ binding site [ion binding]; other site 512565004337 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565004338 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 512565004339 putative substrate binding site [chemical binding]; other site 512565004340 putative ATP binding site [chemical binding]; other site 512565004341 Predicted thioesterase [General function prediction only]; Region: COG5496 512565004342 Predicted membrane protein [Function unknown]; Region: COG3428 512565004343 Bacterial PH domain; Region: DUF304; pfam03703 512565004344 Bacterial PH domain; Region: DUF304; pfam03703 512565004345 Uncharacterized conserved protein [Function unknown]; Region: COG3402 512565004346 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565004347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565004348 Walker A motif; other site 512565004349 ATP binding site [chemical binding]; other site 512565004350 Walker B motif; other site 512565004351 arginine finger; other site 512565004352 Protein of unknown function DUF58; Region: DUF58; pfam01882 512565004353 Aerotolerance regulator N-terminal; Region: BatA; cl06567 512565004354 hypothetical protein; Provisional; Region: PRK13685 512565004355 von Willebrand factor type A domain; Region: VWA_2; pfam13519 512565004356 metal ion-dependent adhesion site (MIDAS); other site 512565004357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565004358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004359 active site 512565004360 phosphorylation site [posttranslational modification] 512565004361 intermolecular recognition site; other site 512565004362 dimerization interface [polypeptide binding]; other site 512565004363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565004364 DNA binding residues [nucleotide binding] 512565004365 dimerization interface [polypeptide binding]; other site 512565004366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565004367 Histidine kinase; Region: HisKA_3; pfam07730 512565004368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004369 ATP binding site [chemical binding]; other site 512565004370 Mg2+ binding site [ion binding]; other site 512565004371 G-X-G motif; other site 512565004372 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 512565004373 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 512565004374 NAD(P) binding site [chemical binding]; other site 512565004375 homotetramer interface [polypeptide binding]; other site 512565004376 homodimer interface [polypeptide binding]; other site 512565004377 active site 512565004378 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 512565004379 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 512565004380 NAD binding site [chemical binding]; other site 512565004381 homotetramer interface [polypeptide binding]; other site 512565004382 homodimer interface [polypeptide binding]; other site 512565004383 substrate binding site [chemical binding]; other site 512565004384 active site 512565004385 ferrochelatase; Reviewed; Region: hemH; PRK00035 512565004386 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 512565004387 C-terminal domain interface [polypeptide binding]; other site 512565004388 active site 512565004389 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 512565004390 active site 512565004391 N-terminal domain interface [polypeptide binding]; other site 512565004392 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 512565004393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565004394 active site 512565004395 motif I; other site 512565004396 motif II; other site 512565004397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565004398 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565004399 nudix motif; other site 512565004400 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 512565004401 nudix motif; other site 512565004402 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565004403 nudix motif; other site 512565004404 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 512565004405 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 512565004406 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565004407 DNA-binding site [nucleotide binding]; DNA binding site 512565004408 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565004409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565004410 homodimer interface [polypeptide binding]; other site 512565004411 catalytic residue [active] 512565004412 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 512565004413 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 512565004414 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 512565004415 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565004416 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565004417 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565004418 anti sigma factor interaction site; other site 512565004419 regulatory phosphorylation site [posttranslational modification]; other site 512565004420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565004421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004422 active site 512565004423 phosphorylation site [posttranslational modification] 512565004424 intermolecular recognition site; other site 512565004425 dimerization interface [polypeptide binding]; other site 512565004426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565004427 DNA binding site [nucleotide binding] 512565004428 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 512565004429 FMN reductase; Validated; Region: fre; PRK08051 512565004430 FAD binding pocket [chemical binding]; other site 512565004431 FAD binding motif [chemical binding]; other site 512565004432 phosphate binding motif [ion binding]; other site 512565004433 beta-alpha-beta structure motif; other site 512565004434 NAD binding pocket [chemical binding]; other site 512565004435 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 512565004436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512565004437 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565004438 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565004439 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 512565004440 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565004441 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512565004442 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512565004443 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512565004444 putative active site [active] 512565004445 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565004446 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565004447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565004448 dimer interface [polypeptide binding]; other site 512565004449 conserved gate region; other site 512565004450 putative PBP binding loops; other site 512565004451 ABC-ATPase subunit interface; other site 512565004452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565004453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565004454 ABC-ATPase subunit interface; other site 512565004455 putative PBP binding loops; other site 512565004456 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 512565004457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565004458 putative PBP binding loops; other site 512565004459 dimer interface [polypeptide binding]; other site 512565004460 ABC-ATPase subunit interface; other site 512565004461 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565004462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565004463 dimer interface [polypeptide binding]; other site 512565004464 conserved gate region; other site 512565004465 putative PBP binding loops; other site 512565004466 ABC-ATPase subunit interface; other site 512565004467 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 512565004468 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 512565004469 active site 512565004470 DNA binding site [nucleotide binding] 512565004471 catalytic site [active] 512565004472 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 512565004473 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 512565004474 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 512565004475 substrate binding pocket [chemical binding]; other site 512565004476 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 512565004477 B12 binding site [chemical binding]; other site 512565004478 cobalt ligand [ion binding]; other site 512565004479 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 512565004480 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 512565004481 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 512565004482 2TM domain; Region: 2TM; pfam13239 512565004483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565004484 Histidine kinase; Region: HisKA_3; pfam07730 512565004485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004486 ATP binding site [chemical binding]; other site 512565004487 Mg2+ binding site [ion binding]; other site 512565004488 G-X-G motif; other site 512565004489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565004490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004491 active site 512565004492 phosphorylation site [posttranslational modification] 512565004493 intermolecular recognition site; other site 512565004494 dimerization interface [polypeptide binding]; other site 512565004495 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565004496 DNA binding residues [nucleotide binding] 512565004497 dimerization interface [polypeptide binding]; other site 512565004498 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 512565004499 nudix motif; other site 512565004500 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565004501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565004502 metal binding site [ion binding]; metal-binding site 512565004503 active site 512565004504 I-site; other site 512565004505 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 512565004506 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565004507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565004508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565004509 DNA binding residues [nucleotide binding] 512565004510 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 512565004511 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 512565004512 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512565004513 conserved cys residue [active] 512565004514 Spt5 C-terminal nonapeptide repeat binding Spt4; Region: CTD; cl17750 512565004515 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512565004516 Response regulator receiver domain; Region: Response_reg; pfam00072 512565004517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004518 active site 512565004519 phosphorylation site [posttranslational modification] 512565004520 intermolecular recognition site; other site 512565004521 dimerization interface [polypeptide binding]; other site 512565004522 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565004523 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565004524 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 512565004525 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565004526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565004527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565004528 LabA_like proteins; Region: LabA_like; cd06167 512565004529 putative metal binding site [ion binding]; other site 512565004530 Uncharacterized conserved protein [Function unknown]; Region: COG1432 512565004531 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565004532 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565004533 Right handed beta helix region; Region: Beta_helix; pfam13229 512565004534 DNA polymerase IV; Provisional; Region: PRK03348 512565004535 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 512565004536 active site 512565004537 DNA binding site [nucleotide binding] 512565004538 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 512565004539 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 512565004540 dimer interface [polypeptide binding]; other site 512565004541 PYR/PP interface [polypeptide binding]; other site 512565004542 TPP binding site [chemical binding]; other site 512565004543 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512565004544 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 512565004545 TPP-binding site [chemical binding]; other site 512565004546 dimer interface [polypeptide binding]; other site 512565004547 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 512565004548 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 512565004549 D-pathway; other site 512565004550 Putative ubiquinol binding site [chemical binding]; other site 512565004551 Low-spin heme (heme b) binding site [chemical binding]; other site 512565004552 Putative water exit pathway; other site 512565004553 Binuclear center (heme o3/CuB) [ion binding]; other site 512565004554 K-pathway; other site 512565004555 Putative proton exit pathway; other site 512565004556 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565004557 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565004558 GtrA-like protein; Region: GtrA; pfam04138 512565004559 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 512565004560 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 512565004561 metal binding site [ion binding]; metal-binding site 512565004562 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565004563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565004564 NAD(P) binding site [chemical binding]; other site 512565004565 active site 512565004566 Cytochrome P450; Region: p450; cl12078 512565004567 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565004568 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565004569 active site 512565004570 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 512565004571 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565004572 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565004573 acyl-activating enzyme (AAE) consensus motif; other site 512565004574 acyl-activating enzyme (AAE) consensus motif; other site 512565004575 AMP binding site [chemical binding]; other site 512565004576 active site 512565004577 CoA binding site [chemical binding]; other site 512565004578 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565004579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565004580 active site 512565004581 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 512565004582 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 512565004583 active site 512565004584 PAS fold; Region: PAS; pfam00989 512565004585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004586 putative active site [active] 512565004587 heme pocket [chemical binding]; other site 512565004588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004589 dimer interface [polypeptide binding]; other site 512565004590 phosphorylation site [posttranslational modification] 512565004591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004592 ATP binding site [chemical binding]; other site 512565004593 G-X-G motif; other site 512565004594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004595 active site 512565004596 phosphorylation site [posttranslational modification] 512565004597 intermolecular recognition site; other site 512565004598 dimerization interface [polypeptide binding]; other site 512565004599 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565004600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565004601 active site 512565004602 ATP binding site [chemical binding]; other site 512565004603 substrate binding site [chemical binding]; other site 512565004604 activation loop (A-loop); other site 512565004605 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 512565004606 active site 512565004607 putative catalytic site [active] 512565004608 PAS domain S-box; Region: sensory_box; TIGR00229 512565004609 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004610 putative active site [active] 512565004611 heme pocket [chemical binding]; other site 512565004612 GAF domain; Region: GAF; pfam01590 512565004613 GAF domain; Region: GAF_2; pfam13185 512565004614 PAS domain S-box; Region: sensory_box; TIGR00229 512565004615 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004616 putative active site [active] 512565004617 heme pocket [chemical binding]; other site 512565004618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004619 PAS domain; Region: PAS_9; pfam13426 512565004620 putative active site [active] 512565004621 heme pocket [chemical binding]; other site 512565004622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004623 PAS domain; Region: PAS_9; pfam13426 512565004624 putative active site [active] 512565004625 heme pocket [chemical binding]; other site 512565004626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565004627 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004628 dimer interface [polypeptide binding]; other site 512565004629 phosphorylation site [posttranslational modification] 512565004630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004631 ATP binding site [chemical binding]; other site 512565004632 Mg2+ binding site [ion binding]; other site 512565004633 G-X-G motif; other site 512565004634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565004635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565004636 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565004637 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 512565004638 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512565004639 Domain of unknown function DUF21; Region: DUF21; pfam01595 512565004640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512565004641 Transporter associated domain; Region: CorC_HlyC; smart01091 512565004642 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 512565004643 transmembrane helices; other site 512565004644 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 512565004645 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 512565004646 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 512565004647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512565004648 Soluble P-type ATPase [General function prediction only]; Region: COG4087 512565004649 K+-transporting ATPase, c chain; Region: KdpC; cl00944 512565004650 K+-transporting ATPase, c chain; Region: KdpC; cl00944 512565004651 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 512565004652 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 512565004653 Ligand Binding Site [chemical binding]; other site 512565004654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004655 dimer interface [polypeptide binding]; other site 512565004656 phosphorylation site [posttranslational modification] 512565004657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004658 ATP binding site [chemical binding]; other site 512565004659 Mg2+ binding site [ion binding]; other site 512565004660 G-X-G motif; other site 512565004661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004662 dimer interface [polypeptide binding]; other site 512565004663 phosphorylation site [posttranslational modification] 512565004664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004665 ATP binding site [chemical binding]; other site 512565004666 Mg2+ binding site [ion binding]; other site 512565004667 G-X-G motif; other site 512565004668 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 512565004669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004670 active site 512565004671 phosphorylation site [posttranslational modification] 512565004672 intermolecular recognition site; other site 512565004673 dimerization interface [polypeptide binding]; other site 512565004674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565004675 DNA binding site [nucleotide binding] 512565004676 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565004677 GAF domain; Region: GAF_2; pfam13185 512565004678 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565004679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565004680 dimer interface [polypeptide binding]; other site 512565004681 putative CheW interface [polypeptide binding]; other site 512565004682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565004683 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565004684 NAD(P) binding site [chemical binding]; other site 512565004685 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 512565004686 classical (c) SDRs; Region: SDR_c; cd05233 512565004687 NAD(P) binding site [chemical binding]; other site 512565004688 active site 512565004689 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565004690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565004691 putative substrate translocation pore; other site 512565004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565004693 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 512565004694 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 512565004695 putative molybdopterin cofactor binding site [chemical binding]; other site 512565004696 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 512565004697 putative molybdopterin cofactor binding site; other site 512565004698 hypothetical protein; Provisional; Region: PRK06547 512565004699 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 512565004700 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565004701 substrate binding site [chemical binding]; other site 512565004702 ATP binding site [chemical binding]; other site 512565004703 CHASE domain; Region: CHASE; pfam03924 512565004704 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565004705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004706 dimer interface [polypeptide binding]; other site 512565004707 phosphorylation site [posttranslational modification] 512565004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004709 ATP binding site [chemical binding]; other site 512565004710 Mg2+ binding site [ion binding]; other site 512565004711 G-X-G motif; other site 512565004712 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 512565004713 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565004714 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 512565004715 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 512565004716 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 512565004717 calcium binding site 2 [ion binding]; other site 512565004718 active site 512565004719 catalytic triad [active] 512565004720 calcium binding site 1 [ion binding]; other site 512565004721 MASE1; Region: MASE1; cl17823 512565004722 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565004723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004724 dimer interface [polypeptide binding]; other site 512565004725 phosphorylation site [posttranslational modification] 512565004726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004727 ATP binding site [chemical binding]; other site 512565004728 Mg2+ binding site [ion binding]; other site 512565004729 G-X-G motif; other site 512565004730 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565004731 GAF domain; Region: GAF; pfam01590 512565004732 PAS fold; Region: PAS; pfam00989 512565004733 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004734 putative active site [active] 512565004735 heme pocket [chemical binding]; other site 512565004736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004737 PAS domain; Region: PAS_9; pfam13426 512565004738 putative active site [active] 512565004739 heme pocket [chemical binding]; other site 512565004740 PAS domain S-box; Region: sensory_box; TIGR00229 512565004741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004742 putative active site [active] 512565004743 heme pocket [chemical binding]; other site 512565004744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565004745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004746 dimer interface [polypeptide binding]; other site 512565004747 phosphorylation site [posttranslational modification] 512565004748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004749 ATP binding site [chemical binding]; other site 512565004750 Mg2+ binding site [ion binding]; other site 512565004751 G-X-G motif; other site 512565004752 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565004753 GAF domain; Region: GAF; pfam01590 512565004754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565004755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004756 dimer interface [polypeptide binding]; other site 512565004757 phosphorylation site [posttranslational modification] 512565004758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004759 ATP binding site [chemical binding]; other site 512565004760 Mg2+ binding site [ion binding]; other site 512565004761 G-X-G motif; other site 512565004762 MASE1; Region: MASE1; cl17823 512565004763 PAS domain; Region: PAS; smart00091 512565004764 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565004765 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004766 dimer interface [polypeptide binding]; other site 512565004767 phosphorylation site [posttranslational modification] 512565004768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004769 ATP binding site [chemical binding]; other site 512565004770 Mg2+ binding site [ion binding]; other site 512565004771 G-X-G motif; other site 512565004772 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 512565004773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565004774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565004775 homodimer interface [polypeptide binding]; other site 512565004776 catalytic residue [active] 512565004777 RDD family; Region: RDD; pfam06271 512565004778 Short C-terminal domain; Region: SHOCT; pfam09851 512565004779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 512565004780 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 512565004781 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 512565004782 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 512565004783 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 512565004784 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565004785 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 512565004786 Sulfate transporter family; Region: Sulfate_transp; pfam00916 512565004787 Sulfate transporter family; Region: Sulfate_transp; pfam00916 512565004788 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 512565004789 alpha-glucosidase; Provisional; Region: PRK10137 512565004790 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 512565004791 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565004792 active site 512565004793 catalytic site [active] 512565004794 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 512565004795 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565004796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565004797 DNA binding residues [nucleotide binding] 512565004798 dimerization interface [polypeptide binding]; other site 512565004799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565004800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565004801 DNA binding residues [nucleotide binding] 512565004802 dimerization interface [polypeptide binding]; other site 512565004803 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 512565004804 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 512565004805 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 512565004806 putative active site [active] 512565004807 putative dimer interface [polypeptide binding]; other site 512565004808 Amidinotransferase; Region: Amidinotransf; cl12043 512565004809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565004810 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512565004811 active site 512565004812 metal binding site [ion binding]; metal-binding site 512565004813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565004814 putative substrate translocation pore; other site 512565004815 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565004816 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 512565004817 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 512565004818 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 512565004819 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 512565004820 Ion channel; Region: Ion_trans_2; pfam07885 512565004821 hypothetical protein; Provisional; Region: PRK07907 512565004822 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 512565004823 active site 512565004824 metal binding site [ion binding]; metal-binding site 512565004825 dimer interface [polypeptide binding]; other site 512565004826 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 512565004827 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 512565004828 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 512565004829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565004830 putative substrate translocation pore; other site 512565004831 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 512565004832 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 512565004833 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 512565004834 active site 512565004835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565004836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565004837 DNA binding residues [nucleotide binding] 512565004838 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565004839 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565004840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565004841 Walker A/P-loop; other site 512565004842 ATP binding site [chemical binding]; other site 512565004843 Q-loop/lid; other site 512565004844 ABC transporter signature motif; other site 512565004845 Walker B; other site 512565004846 D-loop; other site 512565004847 H-loop/switch region; other site 512565004848 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565004849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565004850 Q-loop/lid; other site 512565004851 ABC transporter signature motif; other site 512565004852 Walker B; other site 512565004853 D-loop; other site 512565004854 H-loop/switch region; other site 512565004855 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565004856 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 512565004857 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 512565004858 FAD binding pocket [chemical binding]; other site 512565004859 FAD binding motif [chemical binding]; other site 512565004860 phosphate binding motif [ion binding]; other site 512565004861 NAD binding pocket [chemical binding]; other site 512565004862 GAF domain; Region: GAF; pfam01590 512565004863 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565004864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004865 dimer interface [polypeptide binding]; other site 512565004866 phosphorylation site [posttranslational modification] 512565004867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004868 ATP binding site [chemical binding]; other site 512565004869 Mg2+ binding site [ion binding]; other site 512565004870 G-X-G motif; other site 512565004871 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565004872 GAF domain; Region: GAF_2; pfam13185 512565004873 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 512565004874 NmrA-like family; Region: NmrA; pfam05368 512565004875 NADP binding site [chemical binding]; other site 512565004876 active site 512565004877 regulatory binding site [polypeptide binding]; other site 512565004878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565004879 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512565004880 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 512565004881 Soluble P-type ATPase [General function prediction only]; Region: COG4087 512565004882 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 512565004883 putative ADP-binding pocket [chemical binding]; other site 512565004884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565004885 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565004886 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565004887 active site 512565004888 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 512565004889 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 512565004890 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 512565004891 active site 512565004892 catalytic triad [active] 512565004893 oxyanion hole [active] 512565004894 Rdx family; Region: Rdx; cl01407 512565004895 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 512565004896 Predicted permease; Region: DUF318; cl17795 512565004897 TIGR03943 family protein; Region: TIGR03943 512565004898 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 512565004899 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 512565004900 dimer interface [polypeptide binding]; other site 512565004901 active site 512565004902 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565004903 catalytic residues [active] 512565004904 substrate binding site [chemical binding]; other site 512565004905 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 512565004906 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 512565004907 dimer interface [polypeptide binding]; other site 512565004908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565004909 catalytic residue [active] 512565004910 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 512565004911 active site residue [active] 512565004912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565004913 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 512565004914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565004915 catalytic residue [active] 512565004916 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565004917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565004918 S-adenosylmethionine binding site [chemical binding]; other site 512565004919 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 512565004920 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 512565004921 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 512565004922 CopC domain; Region: CopC; pfam04234 512565004923 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 512565004924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 512565004925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565004926 Protein of unknown function (DUF419); Region: DUF419; cl15265 512565004927 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512565004928 DDE superfamily endonuclease; Region: DDE_5; pfam13546 512565004929 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 512565004930 dimer interface [polypeptide binding]; other site 512565004931 putative radical transfer pathway; other site 512565004932 diiron center [ion binding]; other site 512565004933 tyrosyl radical; other site 512565004934 ATP cone domain; Region: ATP-cone; pfam03477 512565004935 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 512565004936 Class I ribonucleotide reductase; Region: RNR_I; cd01679 512565004937 active site 512565004938 dimer interface [polypeptide binding]; other site 512565004939 catalytic residues [active] 512565004940 effector binding site; other site 512565004941 R2 peptide binding site; other site 512565004942 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 512565004943 putative lipid kinase; Reviewed; Region: PRK13057 512565004944 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565004945 AAA ATPase domain; Region: AAA_16; pfam13191 512565004946 Predicted ATPase [General function prediction only]; Region: COG3903 512565004947 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565004948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565004949 S-adenosylmethionine binding site [chemical binding]; other site 512565004950 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 512565004951 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 512565004952 VanW like protein; Region: VanW; pfam04294 512565004953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004954 Response regulator receiver domain; Region: Response_reg; pfam00072 512565004955 active site 512565004956 phosphorylation site [posttranslational modification] 512565004957 intermolecular recognition site; other site 512565004958 dimerization interface [polypeptide binding]; other site 512565004959 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565004960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004961 putative active site [active] 512565004962 heme pocket [chemical binding]; other site 512565004963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 512565004964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004965 ATP binding site [chemical binding]; other site 512565004966 Mg2+ binding site [ion binding]; other site 512565004967 G-X-G motif; other site 512565004968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004969 Response regulator receiver domain; Region: Response_reg; pfam00072 512565004970 active site 512565004971 phosphorylation site [posttranslational modification] 512565004972 intermolecular recognition site; other site 512565004973 dimerization interface [polypeptide binding]; other site 512565004974 PAS fold; Region: PAS_4; pfam08448 512565004975 PAS domain S-box; Region: sensory_box; TIGR00229 512565004976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004977 putative active site [active] 512565004978 heme pocket [chemical binding]; other site 512565004979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565004980 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565004981 putative active site [active] 512565004982 heme pocket [chemical binding]; other site 512565004983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565004984 dimer interface [polypeptide binding]; other site 512565004985 phosphorylation site [posttranslational modification] 512565004986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565004987 ATP binding site [chemical binding]; other site 512565004988 Mg2+ binding site [ion binding]; other site 512565004989 G-X-G motif; other site 512565004990 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565004991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 512565004992 active site 512565004993 phosphorylation site [posttranslational modification] 512565004994 intermolecular recognition site; other site 512565004995 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565004996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565004997 active site 512565004998 phosphorylation site [posttranslational modification] 512565004999 intermolecular recognition site; other site 512565005000 dimerization interface [polypeptide binding]; other site 512565005001 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 512565005002 Integral membrane protein TerC family; Region: TerC; cl10468 512565005003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565005004 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 512565005005 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 512565005006 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565005007 active site 512565005008 catalytic site [active] 512565005009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005010 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565005011 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565005012 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565005013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565005014 active site 512565005015 ATP binding site [chemical binding]; other site 512565005016 substrate binding site [chemical binding]; other site 512565005017 activation loop (A-loop); other site 512565005018 AAA ATPase domain; Region: AAA_16; pfam13191 512565005019 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565005020 GAF domain; Region: GAF_3; pfam13492 512565005021 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565005022 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565005023 metal binding site [ion binding]; metal-binding site 512565005024 active site 512565005025 I-site; other site 512565005026 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565005027 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565005028 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565005029 DNA binding residues [nucleotide binding] 512565005030 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512565005031 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 512565005032 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 512565005033 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 512565005034 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512565005035 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565005036 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 512565005037 Ligand binding site; other site 512565005038 Putative Catalytic site; other site 512565005039 DXD motif; other site 512565005040 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 512565005041 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 512565005042 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 512565005043 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 512565005044 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 512565005045 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565005046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565005047 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 512565005048 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565005049 metal ion-dependent adhesion site (MIDAS); other site 512565005050 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 512565005051 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565005052 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565005053 Methyltransferase domain; Region: Methyltransf_11; pfam08241 512565005054 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 512565005055 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 512565005056 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 512565005057 molybdopterin cofactor binding site; other site 512565005058 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 512565005059 molybdopterin cofactor binding site; other site 512565005060 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 512565005061 Flavodoxin; Region: Flavodoxin_1; pfam00258 512565005062 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 512565005063 FAD binding pocket [chemical binding]; other site 512565005064 FAD binding motif [chemical binding]; other site 512565005065 catalytic residues [active] 512565005066 NAD binding pocket [chemical binding]; other site 512565005067 phosphate binding motif [ion binding]; other site 512565005068 beta-alpha-beta structure motif; other site 512565005069 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 512565005070 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 512565005071 tetramer interface [polypeptide binding]; other site 512565005072 active site 512565005073 Mg2+/Mn2+ binding site [ion binding]; other site 512565005074 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565005075 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565005076 PAS fold; Region: PAS_4; pfam08448 512565005077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565005078 putative active site [active] 512565005079 heme pocket [chemical binding]; other site 512565005080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565005081 PAS fold; Region: PAS_3; pfam08447 512565005082 putative active site [active] 512565005083 heme pocket [chemical binding]; other site 512565005084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565005085 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565005086 dimer interface [polypeptide binding]; other site 512565005087 phosphorylation site [posttranslational modification] 512565005088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565005089 ATP binding site [chemical binding]; other site 512565005090 Mg2+ binding site [ion binding]; other site 512565005091 G-X-G motif; other site 512565005092 Response regulator receiver domain; Region: Response_reg; pfam00072 512565005093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565005094 active site 512565005095 phosphorylation site [posttranslational modification] 512565005096 intermolecular recognition site; other site 512565005097 dimerization interface [polypeptide binding]; other site 512565005098 Pectinesterase; Region: Pectinesterase; pfam01095 512565005099 putative pectinesterase; Region: PLN02432; cl01911 512565005100 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 512565005101 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 512565005102 DNA binding residues [nucleotide binding] 512565005103 drug binding residues [chemical binding]; other site 512565005104 dimer interface [polypeptide binding]; other site 512565005105 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 512565005106 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565005107 active site 512565005108 metal binding site [ion binding]; metal-binding site 512565005109 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 512565005110 CoenzymeA binding site [chemical binding]; other site 512565005111 subunit interaction site [polypeptide binding]; other site 512565005112 PHB binding site; other site 512565005113 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 512565005114 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 512565005115 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 512565005116 hydrophobic ligand binding site; other site 512565005117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005118 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005119 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 512565005120 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005123 active site 512565005124 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565005125 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 512565005126 DUF35 OB-fold domain; Region: DUF35; pfam01796 512565005127 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565005128 active site 2 [active] 512565005129 active site 1 [active] 512565005130 lipid-transfer protein; Provisional; Region: PRK07855 512565005131 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 512565005132 active site 512565005133 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 512565005134 NAD(P) binding site [chemical binding]; other site 512565005135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565005136 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565005137 active site 512565005138 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565005139 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565005140 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 512565005141 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 512565005142 active site 512565005143 catalytic residues [active] 512565005144 metal binding site [ion binding]; metal-binding site 512565005145 DmpG-like communication domain; Region: DmpG_comm; pfam07836 512565005146 acetaldehyde dehydrogenase; Validated; Region: PRK08300 512565005147 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 512565005148 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 512565005149 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 512565005150 hypothetical protein; Validated; Region: PRK07121 512565005151 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 512565005152 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 512565005153 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 512565005154 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 512565005155 FAD binding pocket [chemical binding]; other site 512565005156 FAD binding motif [chemical binding]; other site 512565005157 phosphate binding motif [ion binding]; other site 512565005158 beta-alpha-beta structure motif; other site 512565005159 NAD(p) ribose binding residues [chemical binding]; other site 512565005160 NAD binding pocket [chemical binding]; other site 512565005161 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 512565005162 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565005163 catalytic loop [active] 512565005164 iron binding site [ion binding]; other site 512565005165 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 512565005166 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 512565005167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005168 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 512565005169 Flavin binding site [chemical binding]; other site 512565005170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565005171 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565005172 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 512565005173 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 512565005174 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 512565005175 active site 512565005176 Fe binding site [ion binding]; other site 512565005177 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565005178 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565005179 putative active site [active] 512565005180 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 512565005181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005182 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 512565005183 active site 512565005184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005185 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005186 active site 512565005187 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005188 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005189 active site 512565005190 enoyl-CoA hydratase; Provisional; Region: PRK08290 512565005191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565005192 substrate binding site [chemical binding]; other site 512565005193 oxyanion hole (OAH) forming residues; other site 512565005194 trimer interface [polypeptide binding]; other site 512565005195 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 512565005196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565005197 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 512565005198 acyl-activating enzyme (AAE) consensus motif; other site 512565005199 putative AMP binding site [chemical binding]; other site 512565005200 putative active site [active] 512565005201 putative CoA binding site [chemical binding]; other site 512565005202 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 512565005203 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 512565005204 FAD binding site [chemical binding]; other site 512565005205 substrate binding site [chemical binding]; other site 512565005206 catalytic base [active] 512565005207 short chain dehydrogenase; Provisional; Region: PRK07831 512565005208 classical (c) SDRs; Region: SDR_c; cd05233 512565005209 NAD(P) binding site [chemical binding]; other site 512565005210 active site 512565005211 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 512565005212 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 512565005213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565005214 dimer interface [polypeptide binding]; other site 512565005215 active site 512565005216 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565005217 Cytochrome P450; Region: p450; cl12078 512565005218 HTH domain; Region: HTH_11; pfam08279 512565005219 WYL domain; Region: WYL; pfam13280 512565005220 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512565005221 homotrimer interaction site [polypeptide binding]; other site 512565005222 putative active site [active] 512565005223 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565005224 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 512565005225 active site 512565005226 catalytic triad [active] 512565005227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565005228 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565005229 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 512565005230 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 512565005231 active site 512565005232 lipid-transfer protein; Provisional; Region: PRK07937 512565005233 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 512565005234 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 512565005235 DUF35 OB-fold domain; Region: DUF35; pfam01796 512565005236 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 512565005237 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 512565005238 DUF35 OB-fold domain; Region: DUF35; pfam01796 512565005239 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 512565005240 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565005241 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 512565005242 acyl-activating enzyme (AAE) consensus motif; other site 512565005243 putative AMP binding site [chemical binding]; other site 512565005244 putative active site [active] 512565005245 putative CoA binding site [chemical binding]; other site 512565005246 enoyl-CoA hydratase; Provisional; Region: PRK07799 512565005247 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565005248 substrate binding site [chemical binding]; other site 512565005249 oxyanion hole (OAH) forming residues; other site 512565005250 trimer interface [polypeptide binding]; other site 512565005251 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 512565005252 acyl-CoA synthetase; Validated; Region: PRK07798 512565005253 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565005254 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 512565005255 acyl-activating enzyme (AAE) consensus motif; other site 512565005256 acyl-activating enzyme (AAE) consensus motif; other site 512565005257 putative AMP binding site [chemical binding]; other site 512565005258 putative active site [active] 512565005259 putative CoA binding site [chemical binding]; other site 512565005260 Nitronate monooxygenase; Region: NMO; pfam03060 512565005261 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 512565005262 FMN binding site [chemical binding]; other site 512565005263 substrate binding site [chemical binding]; other site 512565005264 putative catalytic residue [active] 512565005265 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565005266 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565005267 active site 512565005268 DNA binding site [nucleotide binding] 512565005269 Int/Topo IB signature motif; other site 512565005270 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565005271 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565005272 DNA-binding site [nucleotide binding]; DNA binding site 512565005273 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 512565005274 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 512565005275 metal binding site [ion binding]; metal-binding site 512565005276 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 512565005277 active site 512565005278 GIY-YIG motif/motif A; other site 512565005279 catalytic site [active] 512565005280 metal binding site [ion binding]; metal-binding site 512565005281 AAA domain; Region: AAA_25; pfam13481 512565005282 AAA ATPase domain; Region: AAA_16; pfam13191 512565005283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 512565005284 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 512565005285 generic binding surface I; other site 512565005286 generic binding surface II; other site 512565005287 Protein of unknown function DUF262; Region: DUF262; pfam03235 512565005288 Uncharacterized conserved protein [Function unknown]; Region: COG1479 512565005289 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 512565005290 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565005291 Trp repressor protein; Region: Trp_repressor; cl17266 512565005292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 512565005293 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565005294 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 512565005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565005296 non-specific DNA binding site [nucleotide binding]; other site 512565005297 salt bridge; other site 512565005298 sequence-specific DNA binding site [nucleotide binding]; other site 512565005299 Helix-turn-helix domain; Region: HTH_36; pfam13730 512565005300 Helix-turn-helix domain; Region: HTH_17; cl17695 512565005301 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 512565005302 Predicted membrane protein [Function unknown]; Region: COG1511 512565005303 Phage-related protein [Function unknown]; Region: COG5412 512565005304 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565005305 Interdomain contacts; other site 512565005306 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565005307 Interdomain contacts; other site 512565005308 Cytokine receptor motif; other site 512565005309 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 512565005310 Phage terminase large subunit; Region: Terminase_3; cl12054 512565005311 Terminase-like family; Region: Terminase_6; pfam03237 512565005312 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565005313 replicative DNA helicase; Region: DnaB; TIGR00665 512565005314 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 512565005315 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 512565005316 Walker A motif; other site 512565005317 ATP binding site [chemical binding]; other site 512565005318 Walker B motif; other site 512565005319 DNA binding loops [nucleotide binding] 512565005320 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565005321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565005322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565005323 DNA binding residues [nucleotide binding] 512565005324 dimerization interface [polypeptide binding]; other site 512565005325 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 512565005326 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 512565005327 metal binding site [ion binding]; metal-binding site 512565005328 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 512565005329 GIY-YIG motif/motif A; other site 512565005330 active site 512565005331 catalytic site [active] 512565005332 metal binding site [ion binding]; metal-binding site 512565005333 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565005334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565005335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565005336 non-specific DNA binding site [nucleotide binding]; other site 512565005337 salt bridge; other site 512565005338 sequence-specific DNA binding site [nucleotide binding]; other site 512565005339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565005340 non-specific DNA binding site [nucleotide binding]; other site 512565005341 salt bridge; other site 512565005342 sequence-specific DNA binding site [nucleotide binding]; other site 512565005343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565005344 putative DNA binding site [nucleotide binding]; other site 512565005345 putative Zn2+ binding site [ion binding]; other site 512565005346 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565005347 putative active site [active] 512565005348 putative oxidoreductase; Provisional; Region: PRK08275 512565005349 flagellar capping protein; Validated; Region: fliD; PRK06798 512565005350 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 512565005351 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512565005352 cofactor binding site; other site 512565005353 DNA binding site [nucleotide binding] 512565005354 substrate interaction site [chemical binding]; other site 512565005355 T5orf172 domain; Region: T5orf172; pfam10544 512565005356 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565005357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565005358 non-specific DNA binding site [nucleotide binding]; other site 512565005359 salt bridge; other site 512565005360 sequence-specific DNA binding site [nucleotide binding]; other site 512565005361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565005362 non-specific DNA binding site [nucleotide binding]; other site 512565005363 salt bridge; other site 512565005364 sequence-specific DNA binding site [nucleotide binding]; other site 512565005365 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565005366 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565005367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565005368 Walker A/P-loop; other site 512565005369 ATP binding site [chemical binding]; other site 512565005370 Q-loop/lid; other site 512565005371 ABC transporter signature motif; other site 512565005372 Walker B; other site 512565005373 D-loop; other site 512565005374 H-loop/switch region; other site 512565005375 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565005376 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 512565005377 NAD binding site [chemical binding]; other site 512565005378 catalytic Zn binding site [ion binding]; other site 512565005379 substrate binding site [chemical binding]; other site 512565005380 structural Zn binding site [ion binding]; other site 512565005381 short chain dehydrogenase; Provisional; Region: PRK07890 512565005382 classical (c) SDRs; Region: SDR_c; cd05233 512565005383 NAD(P) binding site [chemical binding]; other site 512565005384 active site 512565005385 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 512565005386 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 512565005387 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565005388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005389 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005390 active site 512565005391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005393 active site 512565005394 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 512565005395 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565005396 dimer interface [polypeptide binding]; other site 512565005397 active site 512565005398 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 512565005399 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 512565005400 FMN binding site [chemical binding]; other site 512565005401 substrate binding site [chemical binding]; other site 512565005402 putative catalytic residue [active] 512565005403 Coenzyme A transferase; Region: CoA_trans; cl17247 512565005404 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 512565005405 enoyl-CoA hydratase; Provisional; Region: PRK06495 512565005406 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565005407 substrate binding site [chemical binding]; other site 512565005408 oxyanion hole (OAH) forming residues; other site 512565005409 trimer interface [polypeptide binding]; other site 512565005410 short chain dehydrogenase; Provisional; Region: PRK07856 512565005411 classical (c) SDRs; Region: SDR_c; cd05233 512565005412 NAD(P) binding site [chemical binding]; other site 512565005413 active site 512565005414 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 512565005415 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565005416 NAD(P) binding site [chemical binding]; other site 512565005417 catalytic residues [active] 512565005418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565005419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005421 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565005422 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 512565005423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565005424 NAD(P) binding site [chemical binding]; other site 512565005425 active site 512565005426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565005427 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 512565005428 NAD(P) binding site [chemical binding]; other site 512565005429 active site 512565005430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005432 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 512565005433 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 512565005434 NAD binding site [chemical binding]; other site 512565005435 catalytic Zn binding site [ion binding]; other site 512565005436 substrate binding site [chemical binding]; other site 512565005437 structural Zn binding site [ion binding]; other site 512565005438 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 512565005439 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565005440 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 512565005441 putative metal binding site [ion binding]; other site 512565005442 Transcriptional regulators [Transcription]; Region: GntR; COG1802 512565005443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565005444 DNA-binding site [nucleotide binding]; DNA binding site 512565005445 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 512565005446 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 512565005447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565005448 catalytic residue [active] 512565005449 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 512565005450 putative active site [active] 512565005451 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 512565005452 active site 512565005453 catalytic triad [active] 512565005454 oxyanion hole [active] 512565005455 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565005456 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 512565005457 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 512565005458 catalytic domain interface [polypeptide binding]; other site 512565005459 homodimer interface [polypeptide binding]; other site 512565005460 putative active site [active] 512565005461 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565005462 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565005463 active site 512565005464 catalytic tetrad [active] 512565005465 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 512565005466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565005467 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 512565005468 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 512565005469 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565005470 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565005471 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 512565005472 active site 512565005473 catalytic triad [active] 512565005474 oxyanion hole [active] 512565005475 DivIVA protein; Region: DivIVA; pfam05103 512565005476 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565005477 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005478 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 512565005479 active site 512565005480 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565005481 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565005482 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 512565005483 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565005484 FAD binding domain; Region: FAD_binding_4; pfam01565 512565005485 Berberine and berberine like; Region: BBE; pfam08031 512565005486 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565005487 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565005488 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565005489 substrate binding site [chemical binding]; other site 512565005490 ATP binding site [chemical binding]; other site 512565005491 Histidine kinase; Region: HisKA_3; pfam07730 512565005492 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565005493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565005494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565005495 active site 512565005496 phosphorylation site [posttranslational modification] 512565005497 intermolecular recognition site; other site 512565005498 dimerization interface [polypeptide binding]; other site 512565005499 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565005500 DNA binding residues [nucleotide binding] 512565005501 dimerization interface [polypeptide binding]; other site 512565005502 Domain of unknown function (DUF385); Region: DUF385; pfam04075 512565005503 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565005504 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565005505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565005506 ABC transporter signature motif; other site 512565005507 Walker B; other site 512565005508 D-loop; other site 512565005509 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565005510 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565005511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565005512 Walker A/P-loop; other site 512565005513 ATP binding site [chemical binding]; other site 512565005514 Q-loop/lid; other site 512565005515 ABC transporter signature motif; other site 512565005516 Walker B; other site 512565005517 D-loop; other site 512565005518 H-loop/switch region; other site 512565005519 Transposase domain (DUF772); Region: DUF772; pfam05598 512565005520 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565005521 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565005522 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 512565005523 homodimer interface [polypeptide binding]; other site 512565005524 glycosyltransferase, MGT family; Region: MGT; TIGR01426 512565005525 active site 512565005526 TDP-binding site; other site 512565005527 acceptor substrate-binding pocket; other site 512565005528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005530 Predicted amidohydrolase [General function prediction only]; Region: COG0388 512565005531 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 512565005532 active site 512565005533 catalytic triad [active] 512565005534 dimer interface [polypeptide binding]; other site 512565005535 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565005536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565005537 DNA binding residues [nucleotide binding] 512565005538 Cache domain; Region: Cache_1; pfam02743 512565005539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565005540 dimerization interface [polypeptide binding]; other site 512565005541 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565005542 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565005543 dimer interface [polypeptide binding]; other site 512565005544 putative CheW interface [polypeptide binding]; other site 512565005545 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 512565005546 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 512565005547 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 512565005548 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 512565005549 homodimer interface [polypeptide binding]; other site 512565005550 substrate-cofactor binding pocket; other site 512565005551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565005552 catalytic residue [active] 512565005553 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 512565005554 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 512565005555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005557 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 512565005558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565005559 putative substrate translocation pore; other site 512565005560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 512565005561 dimerization interface [polypeptide binding]; other site 512565005562 DNA binding residues [nucleotide binding] 512565005563 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 512565005564 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 512565005565 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 512565005566 active site 512565005567 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565005568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565005569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565005570 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565005571 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565005572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565005573 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565005574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565005575 non-specific DNA binding site [nucleotide binding]; other site 512565005576 salt bridge; other site 512565005577 sequence-specific DNA binding site [nucleotide binding]; other site 512565005578 AAA ATPase domain; Region: AAA_16; pfam13191 512565005579 AAA ATPase domain; Region: AAA_16; pfam13191 512565005580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565005581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565005582 DNA binding residues [nucleotide binding] 512565005583 dimerization interface [polypeptide binding]; other site 512565005584 EamA-like transporter family; Region: EamA; pfam00892 512565005585 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 512565005586 EamA-like transporter family; Region: EamA; pfam00892 512565005587 AAA domain; Region: AAA_11; pfam13086 512565005588 Part of AAA domain; Region: AAA_19; pfam13245 512565005589 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565005590 AAA domain; Region: AAA_12; pfam13087 512565005591 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 512565005592 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 512565005593 N- and C-terminal domain interface [polypeptide binding]; other site 512565005594 active site 512565005595 MgATP binding site [chemical binding]; other site 512565005596 catalytic site [active] 512565005597 metal binding site [ion binding]; metal-binding site 512565005598 xylulose binding site [chemical binding]; other site 512565005599 putative homodimer interface [polypeptide binding]; other site 512565005600 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 512565005601 intersubunit interface [polypeptide binding]; other site 512565005602 active site 512565005603 Zn2+ binding site [ion binding]; other site 512565005604 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 512565005605 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565005606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565005607 catalytic residue [active] 512565005608 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 512565005609 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 512565005610 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565005611 N-acetyltransferase; Region: Acetyltransf_2; cl00949 512565005612 PAS domain S-box; Region: sensory_box; TIGR00229 512565005613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565005614 putative active site [active] 512565005615 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565005616 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565005617 metal binding site [ion binding]; metal-binding site 512565005618 active site 512565005619 I-site; other site 512565005620 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565005621 Cytochrome P450; Region: p450; cl12078 512565005622 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 512565005623 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 512565005624 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 512565005625 hypothetical protein; Provisional; Region: PRK11770 512565005626 Domain of unknown function (DUF307); Region: DUF307; pfam03733 512565005627 Domain of unknown function (DUF307); Region: DUF307; pfam03733 512565005628 Ion transport protein; Region: Ion_trans; pfam00520 512565005629 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 512565005630 active site 512565005631 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 512565005632 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 512565005633 active site 512565005634 metal binding site [ion binding]; metal-binding site 512565005635 nudix motif; other site 512565005636 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; TIGR03429 512565005637 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 512565005638 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 512565005639 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565005640 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565005641 catalytic residue [active] 512565005642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565005643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565005644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565005645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565005646 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 512565005647 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565005648 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 512565005649 G1 box; other site 512565005650 GTP/Mg2+ binding site [chemical binding]; other site 512565005651 G2 box; other site 512565005652 Switch I region; other site 512565005653 G3 box; other site 512565005654 Switch II region; other site 512565005655 G4 box; other site 512565005656 Protein of unknown function (DUF742); Region: DUF742; pfam05331 512565005657 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 512565005658 Nitrate and nitrite sensing; Region: NIT; pfam08376 512565005659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565005660 ATP binding site [chemical binding]; other site 512565005661 Mg2+ binding site [ion binding]; other site 512565005662 G-X-G motif; other site 512565005663 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 512565005664 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 512565005665 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 512565005666 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565005667 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565005668 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565005669 anti sigma factor interaction site; other site 512565005670 regulatory phosphorylation site [posttranslational modification]; other site 512565005671 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565005672 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 512565005673 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512565005674 ATP binding site [chemical binding]; other site 512565005675 Mg++ binding site [ion binding]; other site 512565005676 motif III; other site 512565005677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565005678 nucleotide binding region [chemical binding]; other site 512565005679 ATP-binding site [chemical binding]; other site 512565005680 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 512565005681 RNA binding site [nucleotide binding]; other site 512565005682 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 512565005683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565005684 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 512565005685 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565005686 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 512565005687 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 512565005688 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 512565005689 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 512565005690 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 512565005691 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565005692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565005693 dimerization interface [polypeptide binding]; other site 512565005694 putative DNA binding site [nucleotide binding]; other site 512565005695 putative Zn2+ binding site [ion binding]; other site 512565005696 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 512565005697 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565005698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565005699 DNA-binding site [nucleotide binding]; DNA binding site 512565005700 UTRA domain; Region: UTRA; pfam07702 512565005701 Phosphotransferase enzyme family; Region: APH; pfam01636 512565005702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565005703 active site 512565005704 ATP binding site [chemical binding]; other site 512565005705 MarC family integral membrane protein; Region: MarC; cl00919 512565005706 arginine deiminase; Provisional; Region: PRK01388 512565005707 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 512565005708 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 512565005709 NACHT domain; Region: NACHT; pfam05729 512565005710 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 512565005711 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 512565005712 putative active site pocket [active] 512565005713 putative metal binding site [ion binding]; other site 512565005714 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512565005715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565005716 dimer interface [polypeptide binding]; other site 512565005717 conserved gate region; other site 512565005718 putative PBP binding loops; other site 512565005719 ABC-ATPase subunit interface; other site 512565005720 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 512565005721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565005722 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512565005723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565005724 Walker A/P-loop; other site 512565005725 ATP binding site [chemical binding]; other site 512565005726 Q-loop/lid; other site 512565005727 ABC transporter signature motif; other site 512565005728 Walker B; other site 512565005729 D-loop; other site 512565005730 H-loop/switch region; other site 512565005731 TOBE domain; Region: TOBE_2; pfam08402 512565005732 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 512565005733 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 512565005734 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565005735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565005736 DNA binding site [nucleotide binding] 512565005737 domain linker motif; other site 512565005738 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565005739 dimerization interface [polypeptide binding]; other site 512565005740 ligand binding site [chemical binding]; other site 512565005741 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 512565005742 Predicted transcriptional regulators [Transcription]; Region: COG1725 512565005743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565005744 DNA-binding site [nucleotide binding]; DNA binding site 512565005745 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565005746 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565005747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005748 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 512565005749 active site 512565005750 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565005751 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 512565005752 NAD(P) binding site [chemical binding]; other site 512565005753 catalytic residues [active] 512565005754 Transcriptional regulators [Transcription]; Region: GntR; COG1802 512565005755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565005756 DNA-binding site [nucleotide binding]; DNA binding site 512565005757 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 512565005758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005760 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 512565005761 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 512565005762 catalytic Zn binding site [ion binding]; other site 512565005763 NAD binding site [chemical binding]; other site 512565005764 structural Zn binding site [ion binding]; other site 512565005765 GXWXG protein; Region: GXWXG; pfam14231 512565005766 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 512565005767 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565005768 Cellulose binding domain; Region: CBM_2; pfam00553 512565005769 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565005770 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 512565005771 molybdopterin cofactor binding site; other site 512565005772 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 512565005773 putative molybdopterin cofactor binding site; other site 512565005774 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565005775 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565005776 Walker A/P-loop; other site 512565005777 ATP binding site [chemical binding]; other site 512565005778 Q-loop/lid; other site 512565005779 ABC transporter signature motif; other site 512565005780 Walker B; other site 512565005781 D-loop; other site 512565005782 H-loop/switch region; other site 512565005783 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565005784 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565005785 Walker A/P-loop; other site 512565005786 ATP binding site [chemical binding]; other site 512565005787 Q-loop/lid; other site 512565005788 ABC transporter signature motif; other site 512565005789 Walker B; other site 512565005790 D-loop; other site 512565005791 H-loop/switch region; other site 512565005792 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565005793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565005794 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565005795 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 512565005796 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565005797 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 512565005798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565005799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565005800 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565005801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565005802 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512565005803 Walker A/P-loop; other site 512565005804 ATP binding site [chemical binding]; other site 512565005805 Q-loop/lid; other site 512565005806 ABC transporter signature motif; other site 512565005807 Walker B; other site 512565005808 D-loop; other site 512565005809 H-loop/switch region; other site 512565005810 ABC transporter; Region: ABC_tran_2; pfam12848 512565005811 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565005812 AAA ATPase domain; Region: AAA_16; pfam13191 512565005813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565005814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565005815 DNA binding residues [nucleotide binding] 512565005816 dimerization interface [polypeptide binding]; other site 512565005817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565005818 Ligand Binding Site [chemical binding]; other site 512565005819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565005820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565005821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512565005822 EamA-like transporter family; Region: EamA; pfam00892 512565005823 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 512565005824 synthetase active site [active] 512565005825 NTP binding site [chemical binding]; other site 512565005826 metal binding site [ion binding]; metal-binding site 512565005827 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565005828 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 512565005829 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 512565005830 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 512565005831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565005832 Asp23 family; Region: Asp23; cl00574 512565005833 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 512565005834 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565005835 active site 512565005836 Ca binding site [ion binding]; other site 512565005837 catalytic site [active] 512565005838 Aamy_C domain; Region: Aamy_C; smart00632 512565005839 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 512565005840 starch-binding site 2 [chemical binding]; other site 512565005841 starch-binding site 1 [chemical binding]; other site 512565005842 AzlC protein; Region: AzlC; pfam03591 512565005843 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 512565005844 active site 512565005845 Zn binding site [ion binding]; other site 512565005846 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565005847 anti sigma factor interaction site; other site 512565005848 regulatory phosphorylation site [posttranslational modification]; other site 512565005849 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 512565005850 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 512565005851 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 512565005852 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 512565005853 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 512565005854 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512565005855 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 512565005856 active site 512565005857 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565005858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565005859 active site 512565005860 phosphorylation site [posttranslational modification] 512565005861 intermolecular recognition site; other site 512565005862 dimerization interface [polypeptide binding]; other site 512565005863 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565005864 DNA binding residues [nucleotide binding] 512565005865 dimerization interface [polypeptide binding]; other site 512565005866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565005867 Histidine kinase; Region: HisKA_3; pfam07730 512565005868 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565005869 ATP binding site [chemical binding]; other site 512565005870 Mg2+ binding site [ion binding]; other site 512565005871 G-X-G motif; other site 512565005872 RibD C-terminal domain; Region: RibD_C; cl17279 512565005873 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512565005874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 512565005876 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 512565005877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565005878 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 512565005879 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 512565005880 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 512565005881 active site 512565005882 catalytic residues [active] 512565005883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565005884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565005885 dimer interface [polypeptide binding]; other site 512565005886 conserved gate region; other site 512565005887 putative PBP binding loops; other site 512565005888 ABC-ATPase subunit interface; other site 512565005889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565005890 dimer interface [polypeptide binding]; other site 512565005891 conserved gate region; other site 512565005892 putative PBP binding loops; other site 512565005893 ABC-ATPase subunit interface; other site 512565005894 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 512565005895 hypothetical protein; Provisional; Region: PRK02947 512565005896 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512565005897 putative active site [active] 512565005898 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512565005899 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512565005900 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512565005901 putative active site [active] 512565005902 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 512565005903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565005904 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 512565005905 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 512565005906 P-loop; other site 512565005907 Magnesium ion binding site [ion binding]; other site 512565005908 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565005909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565005910 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565005911 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565005912 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 512565005913 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 512565005914 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 512565005915 HEXXH motif domain; Region: mod_HExxH; TIGR04267 512565005916 EamA-like transporter family; Region: EamA; pfam00892 512565005917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565005918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565005919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565005920 dimerization interface [polypeptide binding]; other site 512565005921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565005922 Zn2+ binding site [ion binding]; other site 512565005923 Mg2+ binding site [ion binding]; other site 512565005924 ferredoxin-NADP+ reductase; Region: PLN02852 512565005925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565005926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565005927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565005928 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512565005929 active site 512565005930 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565005931 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565005932 Phospholipid methyltransferase; Region: PEMT; cl17370 512565005933 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 512565005934 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 512565005935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565005936 NAD(P) binding site [chemical binding]; other site 512565005937 active site 512565005938 GAF domain; Region: GAF_2; pfam13185 512565005939 GAF domain; Region: GAF; pfam01590 512565005940 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 512565005941 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 512565005942 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 512565005943 DNA-binding site [nucleotide binding]; DNA binding site 512565005944 RNA-binding motif; other site 512565005945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565005946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565005947 active site 512565005948 phosphorylation site [posttranslational modification] 512565005949 intermolecular recognition site; other site 512565005950 dimerization interface [polypeptide binding]; other site 512565005951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565005952 DNA binding residues [nucleotide binding] 512565005953 dimerization interface [polypeptide binding]; other site 512565005954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565005955 Histidine kinase; Region: HisKA_3; pfam07730 512565005956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565005957 ATP binding site [chemical binding]; other site 512565005958 Mg2+ binding site [ion binding]; other site 512565005959 G-X-G motif; other site 512565005960 Tannase and feruloyl esterase; Region: Tannase; pfam07519 512565005961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565005962 putative substrate translocation pore; other site 512565005963 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565005964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565005965 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565005966 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565005967 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 512565005968 catalytic triad [active] 512565005969 MMPL family; Region: MMPL; pfam03176 512565005970 MMPL family; Region: MMPL; pfam03176 512565005971 Membrane transport protein; Region: Mem_trans; cl09117 512565005972 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 512565005973 active site 512565005974 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565005975 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565005976 putative sugar binding sites [chemical binding]; other site 512565005977 Q-X-W motif; other site 512565005978 Amb_all domain; Region: Amb_all; smart00656 512565005979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 512565005980 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512565005981 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 512565005982 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565005983 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 512565005984 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 512565005985 carboxyltransferase (CT) interaction site; other site 512565005986 biotinylation site [posttranslational modification]; other site 512565005987 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 512565005988 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 512565005989 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512565005990 Domain of unknown function DUF21; Region: DUF21; pfam01595 512565005991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512565005992 Transporter associated domain; Region: CorC_HlyC; pfam03471 512565005993 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512565005994 Domain of unknown function DUF21; Region: DUF21; pfam01595 512565005995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512565005996 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565005997 active site 512565005998 catalytic residues [active] 512565005999 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 512565006000 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 512565006001 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565006002 succinic semialdehyde dehydrogenase; Region: PLN02278 512565006003 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 512565006004 tetramerization interface [polypeptide binding]; other site 512565006005 NAD(P) binding site [chemical binding]; other site 512565006006 catalytic residues [active] 512565006007 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 512565006008 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565006009 inhibitor-cofactor binding pocket; inhibition site 512565006010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565006011 catalytic residue [active] 512565006012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565006013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512565006014 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 512565006015 active site 512565006016 catalytic residues [active] 512565006017 MMPL family; Region: MMPL; pfam03176 512565006018 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 512565006019 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565006020 Histidine kinase; Region: HisKA_3; pfam07730 512565006021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006023 active site 512565006024 phosphorylation site [posttranslational modification] 512565006025 intermolecular recognition site; other site 512565006026 dimerization interface [polypeptide binding]; other site 512565006027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006028 DNA binding residues [nucleotide binding] 512565006029 dimerization interface [polypeptide binding]; other site 512565006030 Integrase core domain; Region: rve; pfam00665 512565006031 Integrase core domain; Region: rve_3; pfam13683 512565006032 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565006033 DNA binding site [nucleotide binding] 512565006034 active site 512565006035 Int/Topo IB signature motif; other site 512565006036 Predicted transcriptional regulator [Transcription]; Region: COG2378 512565006037 HTH domain; Region: HTH_11; pfam08279 512565006038 WYL domain; Region: WYL; pfam13280 512565006039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565006040 active site 512565006041 Caspase domain; Region: Peptidase_C14; pfam00656 512565006042 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 512565006043 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565006044 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565006045 catalytic residue [active] 512565006046 Protein of unknown function (DUF2695); Region: DUF2695; pfam10905 512565006047 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 512565006048 aldehyde dehydrogenase family 7 member; Region: PLN02315 512565006049 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 512565006050 tetrameric interface [polypeptide binding]; other site 512565006051 NAD binding site [chemical binding]; other site 512565006052 catalytic residues [active] 512565006053 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 512565006054 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565006055 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565006056 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565006057 ligand binding site [chemical binding]; other site 512565006058 flexible hinge region; other site 512565006059 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 512565006060 Rhodanese Homology Domain; Region: RHOD; smart00450 512565006061 active site residue [active] 512565006062 Domain of unknown function (DUF385); Region: DUF385; cl04387 512565006063 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565006064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006066 DNA binding residues [nucleotide binding] 512565006067 dimerization interface [polypeptide binding]; other site 512565006068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565006069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565006070 metal binding site [ion binding]; metal-binding site 512565006071 active site 512565006072 I-site; other site 512565006073 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565006074 LexA repressor; Validated; Region: PRK00215 512565006075 putative DNA binding site [nucleotide binding]; other site 512565006076 putative Zn2+ binding site [ion binding]; other site 512565006077 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 512565006078 Catalytic site [active] 512565006079 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 512565006080 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 512565006081 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 512565006082 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565006083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565006084 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 512565006085 DNA binding residues [nucleotide binding] 512565006086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565006087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565006088 active site 512565006089 catalytic tetrad [active] 512565006090 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 512565006091 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 512565006092 NADP binding site [chemical binding]; other site 512565006093 active site 512565006094 putative substrate binding site [chemical binding]; other site 512565006095 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 512565006096 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 512565006097 NAD binding site [chemical binding]; other site 512565006098 substrate binding site [chemical binding]; other site 512565006099 homodimer interface [polypeptide binding]; other site 512565006100 active site 512565006101 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 512565006102 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 512565006103 substrate binding site; other site 512565006104 tetramer interface; other site 512565006105 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 512565006106 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 512565006107 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565006108 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 512565006109 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 512565006110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512565006111 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 512565006112 metal ion-dependent adhesion site (MIDAS); other site 512565006113 hypothetical protein; Provisional; Region: PRK07236 512565006114 hypothetical protein; Provisional; Region: PRK07588 512565006115 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565006116 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006117 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 512565006118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565006119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565006120 DNA binding site [nucleotide binding] 512565006121 domain linker motif; other site 512565006122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565006123 ligand binding site [chemical binding]; other site 512565006124 dimerization interface [polypeptide binding]; other site 512565006125 Methane oxygenase PmoA; Region: PmoA; pfam14100 512565006126 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 512565006127 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512565006128 Walker A/P-loop; other site 512565006129 ATP binding site [chemical binding]; other site 512565006130 Q-loop/lid; other site 512565006131 ABC transporter signature motif; other site 512565006132 Walker B; other site 512565006133 D-loop; other site 512565006134 H-loop/switch region; other site 512565006135 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512565006136 Walker A/P-loop; other site 512565006137 ATP binding site [chemical binding]; other site 512565006138 Q-loop/lid; other site 512565006139 ABC transporter signature motif; other site 512565006140 Walker B; other site 512565006141 D-loop; other site 512565006142 H-loop/switch region; other site 512565006143 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 512565006144 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 512565006145 Clp protease ATP binding subunit; Region: clpC; CHL00095 512565006146 Clp amino terminal domain; Region: Clp_N; pfam02861 512565006147 Clp amino terminal domain; Region: Clp_N; pfam02861 512565006148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565006149 Walker A motif; other site 512565006150 ATP binding site [chemical binding]; other site 512565006151 Walker B motif; other site 512565006152 arginine finger; other site 512565006153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565006154 Walker A motif; other site 512565006155 ATP binding site [chemical binding]; other site 512565006156 Walker B motif; other site 512565006157 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 512565006158 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565006159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565006160 non-specific DNA binding site [nucleotide binding]; other site 512565006161 salt bridge; other site 512565006162 sequence-specific DNA binding site [nucleotide binding]; other site 512565006163 AAA ATPase domain; Region: AAA_16; pfam13191 512565006164 NB-ARC domain; Region: NB-ARC; pfam00931 512565006165 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 512565006166 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 512565006167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565006168 DNA-binding site [nucleotide binding]; DNA binding site 512565006169 FCD domain; Region: FCD; pfam07729 512565006170 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 512565006171 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 512565006172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565006173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565006174 dimer interface [polypeptide binding]; other site 512565006175 conserved gate region; other site 512565006176 putative PBP binding loops; other site 512565006177 ABC-ATPase subunit interface; other site 512565006178 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512565006179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565006180 dimer interface [polypeptide binding]; other site 512565006181 conserved gate region; other site 512565006182 putative PBP binding loops; other site 512565006183 ABC-ATPase subunit interface; other site 512565006184 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565006185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565006186 Walker A/P-loop; other site 512565006187 ATP binding site [chemical binding]; other site 512565006188 Q-loop/lid; other site 512565006189 ABC transporter signature motif; other site 512565006190 Walker B; other site 512565006191 D-loop; other site 512565006192 H-loop/switch region; other site 512565006193 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565006194 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565006195 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565006196 Walker A/P-loop; other site 512565006197 ATP binding site [chemical binding]; other site 512565006198 Q-loop/lid; other site 512565006199 ABC transporter signature motif; other site 512565006200 Walker B; other site 512565006201 D-loop; other site 512565006202 H-loop/switch region; other site 512565006203 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565006204 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 512565006205 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 512565006206 inhibitor site; inhibition site 512565006207 active site 512565006208 dimer interface [polypeptide binding]; other site 512565006209 catalytic residue [active] 512565006210 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565006211 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565006212 nucleotide binding site [chemical binding]; other site 512565006213 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 512565006214 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512565006215 phosphate binding site [ion binding]; other site 512565006216 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565006217 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565006218 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 512565006219 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 512565006220 Mechanosensitive ion channel; Region: MS_channel; pfam00924 512565006221 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565006222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006224 DNA binding residues [nucleotide binding] 512565006225 dimerization interface [polypeptide binding]; other site 512565006226 AAA ATPase domain; Region: AAA_16; pfam13191 512565006227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006229 DNA binding residues [nucleotide binding] 512565006230 dimerization interface [polypeptide binding]; other site 512565006231 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 512565006232 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565006233 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565006234 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565006235 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 512565006236 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565006237 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565006238 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565006239 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565006240 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565006241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 512565006242 Cupin domain; Region: Cupin_2; cl17218 512565006243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565006244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565006245 active site 512565006246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565006247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006248 YwiC-like protein; Region: YwiC; pfam14256 512565006249 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 512565006250 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 512565006251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565006252 Walker A/P-loop; other site 512565006253 ATP binding site [chemical binding]; other site 512565006254 Q-loop/lid; other site 512565006255 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 512565006256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565006257 putative PBP binding loops; other site 512565006258 ABC-ATPase subunit interface; other site 512565006259 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 512565006260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512565006261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 512565006262 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 512565006263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565006264 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565006265 calcium mediated ligand binding site; other site 512565006266 intermolecular salt bridges; other site 512565006267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 512565006268 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 512565006269 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 512565006270 putative hydrophobic ligand binding site [chemical binding]; other site 512565006271 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 512565006272 potential frameshift: common BLAST hit: gi|271964551|ref|YP_003338747.1| thiamine pyrophosphate-requiring protein-like protein 512565006273 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 512565006274 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 512565006275 PYR/PP interface [polypeptide binding]; other site 512565006276 dimer interface [polypeptide binding]; other site 512565006277 TPP binding site [chemical binding]; other site 512565006278 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512565006279 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 512565006280 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565006281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565006282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565006283 DNA binding residues [nucleotide binding] 512565006284 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512565006285 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 512565006286 phosphate binding site [ion binding]; other site 512565006287 Dodecin; Region: Dodecin; pfam07311 512565006288 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 512565006289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565006290 non-specific DNA binding site [nucleotide binding]; other site 512565006291 salt bridge; other site 512565006292 sequence-specific DNA binding site [nucleotide binding]; other site 512565006293 Cupin domain; Region: Cupin_2; pfam07883 512565006294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565006295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565006296 putative substrate translocation pore; other site 512565006297 CHASE4 domain; Region: CHASE4; cl01308 512565006298 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565006299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565006300 dimer interface [polypeptide binding]; other site 512565006301 phosphorylation site [posttranslational modification] 512565006302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565006303 ATP binding site [chemical binding]; other site 512565006304 Mg2+ binding site [ion binding]; other site 512565006305 G-X-G motif; other site 512565006306 Response regulator receiver domain; Region: Response_reg; pfam00072 512565006307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006308 active site 512565006309 phosphorylation site [posttranslational modification] 512565006310 intermolecular recognition site; other site 512565006311 dimerization interface [polypeptide binding]; other site 512565006312 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565006313 Ricin-type beta-trefoil; Region: RICIN; smart00458 512565006314 putative sugar binding sites [chemical binding]; other site 512565006315 Q-X-W motif; other site 512565006316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565006317 S-adenosylmethionine binding site [chemical binding]; other site 512565006318 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565006319 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565006320 Walker A/P-loop; other site 512565006321 ATP binding site [chemical binding]; other site 512565006322 Q-loop/lid; other site 512565006323 ABC transporter signature motif; other site 512565006324 Walker B; other site 512565006325 D-loop; other site 512565006326 H-loop/switch region; other site 512565006327 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565006328 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 512565006329 intersubunit interface [polypeptide binding]; other site 512565006330 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565006331 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565006332 ABC-ATPase subunit interface; other site 512565006333 dimer interface [polypeptide binding]; other site 512565006334 putative PBP binding regions; other site 512565006335 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565006336 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 512565006337 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 512565006338 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 512565006339 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565006340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565006341 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 512565006342 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565006343 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 512565006344 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 512565006345 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 512565006346 metal binding site [ion binding]; metal-binding site 512565006347 ligand binding site [chemical binding]; other site 512565006348 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565006349 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565006350 putative sugar binding sites [chemical binding]; other site 512565006351 Q-X-W motif; other site 512565006352 Trehalose utilisation; Region: ThuA; pfam06283 512565006353 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 512565006354 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565006355 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565006356 putative sugar binding sites [chemical binding]; other site 512565006357 Q-X-W motif; other site 512565006358 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 512565006359 Low molecular weight phosphatase family; Region: LMWPc; cd00115 512565006360 active site 512565006361 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 512565006362 amphipathic channel; other site 512565006363 Asn-Pro-Ala signature motifs; other site 512565006364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565006365 dimerization interface [polypeptide binding]; other site 512565006366 putative DNA binding site [nucleotide binding]; other site 512565006367 putative Zn2+ binding site [ion binding]; other site 512565006368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565006369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565006370 potential frameshift: common BLAST hit: gi|256397706|ref|YP_003119270.1| major facilitator superfamily protein 512565006371 Amb_all domain; Region: Amb_all; smart00656 512565006372 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512565006373 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 512565006374 active site 512565006375 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565006376 MarR family; Region: MarR; pfam01047 512565006377 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565006378 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565006379 putative NAD(P) binding site [chemical binding]; other site 512565006380 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 512565006381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565006382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006383 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565006384 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 512565006385 Nitronate monooxygenase; Region: NMO; pfam03060 512565006386 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 512565006387 FMN binding site [chemical binding]; other site 512565006388 substrate binding site [chemical binding]; other site 512565006389 putative catalytic residue [active] 512565006390 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 512565006391 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 512565006392 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565006393 hydrophobic ligand binding site; other site 512565006394 EVE domain; Region: EVE; cl00728 512565006395 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565006396 MarR family; Region: MarR; pfam01047 512565006397 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 512565006398 CHASE3 domain; Region: CHASE3; pfam05227 512565006399 Response regulator receiver domain; Region: Response_reg; pfam00072 512565006400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006401 active site 512565006402 phosphorylation site [posttranslational modification] 512565006403 intermolecular recognition site; other site 512565006404 dimerization interface [polypeptide binding]; other site 512565006405 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 512565006406 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 512565006407 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565006408 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 512565006409 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 512565006410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565006411 motif II; other site 512565006412 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 512565006413 Short C-terminal domain; Region: SHOCT; pfam09851 512565006414 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565006415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565006416 putative substrate translocation pore; other site 512565006417 HTH domain; Region: HTH_11; pfam08279 512565006418 WYL domain; Region: WYL; pfam13280 512565006419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512565006420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565006421 Coenzyme A binding pocket [chemical binding]; other site 512565006422 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565006423 putative oxidoreductase; Provisional; Region: PRK10083 512565006424 NAD(P) binding site [chemical binding]; other site 512565006425 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 512565006426 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565006427 Radical SAM superfamily; Region: Radical_SAM; pfam04055 512565006428 FeS/SAM binding site; other site 512565006429 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 512565006430 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 512565006431 active site 512565006432 acyl-activating enzyme (AAE) consensus motif; other site 512565006433 putative CoA binding site [chemical binding]; other site 512565006434 AMP binding site [chemical binding]; other site 512565006435 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565006436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565006437 substrate binding site [chemical binding]; other site 512565006438 oxyanion hole (OAH) forming residues; other site 512565006439 trimer interface [polypeptide binding]; other site 512565006440 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565006441 RibD C-terminal domain; Region: RibD_C; cl17279 512565006442 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565006443 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565006444 putative active site [active] 512565006445 heme pocket [chemical binding]; other site 512565006446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565006447 dimer interface [polypeptide binding]; other site 512565006448 phosphorylation site [posttranslational modification] 512565006449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565006450 ATP binding site [chemical binding]; other site 512565006451 Mg2+ binding site [ion binding]; other site 512565006452 G-X-G motif; other site 512565006453 Response regulator receiver domain; Region: Response_reg; pfam00072 512565006454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006455 active site 512565006456 phosphorylation site [posttranslational modification] 512565006457 intermolecular recognition site; other site 512565006458 dimerization interface [polypeptide binding]; other site 512565006459 PemK-like protein; Region: PemK; pfam02452 512565006460 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565006461 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565006462 DNA binding residues [nucleotide binding] 512565006463 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565006464 GAF domain; Region: GAF; pfam01590 512565006465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565006466 ATP binding site [chemical binding]; other site 512565006467 Mg2+ binding site [ion binding]; other site 512565006468 G-X-G motif; other site 512565006469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006470 Response regulator receiver domain; Region: Response_reg; pfam00072 512565006471 active site 512565006472 phosphorylation site [posttranslational modification] 512565006473 intermolecular recognition site; other site 512565006474 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006476 active site 512565006477 phosphorylation site [posttranslational modification] 512565006478 intermolecular recognition site; other site 512565006479 dimerization interface [polypeptide binding]; other site 512565006480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006481 DNA binding residues [nucleotide binding] 512565006482 AAA ATPase domain; Region: AAA_16; pfam13191 512565006483 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006484 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006485 DNA binding residues [nucleotide binding] 512565006486 dimerization interface [polypeptide binding]; other site 512565006487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565006488 AAA ATPase domain; Region: AAA_16; pfam13191 512565006489 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006490 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006491 DNA binding residues [nucleotide binding] 512565006492 dimerization interface [polypeptide binding]; other site 512565006493 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 512565006494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565006495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565006496 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565006497 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 512565006498 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565006499 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512565006500 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 512565006501 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 512565006502 short chain dehydrogenase; Provisional; Region: PRK06180 512565006503 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 512565006504 NADP binding site [chemical binding]; other site 512565006505 active site 512565006506 steroid binding site; other site 512565006507 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565006508 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565006509 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565006510 FAD binding domain; Region: FAD_binding_4; pfam01565 512565006511 Berberine and berberine like; Region: BBE; pfam08031 512565006512 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 512565006513 Tannase and feruloyl esterase; Region: Tannase; pfam07519 512565006514 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 512565006515 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 512565006516 PYR/PP interface [polypeptide binding]; other site 512565006517 dimer interface [polypeptide binding]; other site 512565006518 TPP binding site [chemical binding]; other site 512565006519 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512565006520 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 512565006521 TPP-binding site [chemical binding]; other site 512565006522 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565006523 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 512565006524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565006525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565006526 DNA binding residues [nucleotide binding] 512565006527 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512565006528 active site 512565006529 AAA ATPase domain; Region: AAA_16; pfam13191 512565006530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006532 DNA binding residues [nucleotide binding] 512565006533 dimerization interface [polypeptide binding]; other site 512565006534 oxidoreductase; Provisional; Region: PRK06196 512565006535 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 512565006536 putative NAD(P) binding site [chemical binding]; other site 512565006537 active site 512565006538 CHAT domain; Region: CHAT; cl17868 512565006539 NB-ARC domain; Region: NB-ARC; pfam00931 512565006540 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 512565006541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565006542 NAD(P) binding site [chemical binding]; other site 512565006543 active site 512565006544 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565006545 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565006546 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 512565006547 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 512565006548 Cupin; Region: Cupin_6; pfam12852 512565006549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565006550 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565006551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565006552 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 512565006553 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 512565006554 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565006555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565006556 DNA binding residues [nucleotide binding] 512565006557 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512565006558 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565006559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565006560 dimerization interface [polypeptide binding]; other site 512565006561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565006562 dimer interface [polypeptide binding]; other site 512565006563 phosphorylation site [posttranslational modification] 512565006564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565006565 ATP binding site [chemical binding]; other site 512565006566 Mg2+ binding site [ion binding]; other site 512565006567 G-X-G motif; other site 512565006568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565006569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006570 active site 512565006571 phosphorylation site [posttranslational modification] 512565006572 intermolecular recognition site; other site 512565006573 dimerization interface [polypeptide binding]; other site 512565006574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565006575 DNA binding site [nucleotide binding] 512565006576 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565006577 classical (c) SDRs; Region: SDR_c; cd05233 512565006578 NAD(P) binding site [chemical binding]; other site 512565006579 active site 512565006580 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565006581 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565006582 FtsX-like permease family; Region: FtsX; pfam02687 512565006583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565006584 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565006585 Walker A/P-loop; other site 512565006586 ATP binding site [chemical binding]; other site 512565006587 Q-loop/lid; other site 512565006588 ABC transporter signature motif; other site 512565006589 Walker B; other site 512565006590 D-loop; other site 512565006591 H-loop/switch region; other site 512565006592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565006593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006594 active site 512565006595 phosphorylation site [posttranslational modification] 512565006596 intermolecular recognition site; other site 512565006597 dimerization interface [polypeptide binding]; other site 512565006598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565006599 DNA binding site [nucleotide binding] 512565006600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565006601 HAMP domain; Region: HAMP; pfam00672 512565006602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565006603 dimer interface [polypeptide binding]; other site 512565006604 phosphorylation site [posttranslational modification] 512565006605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565006606 ATP binding site [chemical binding]; other site 512565006607 Mg2+ binding site [ion binding]; other site 512565006608 G-X-G motif; other site 512565006609 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565006610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565006611 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565006612 Walker A/P-loop; other site 512565006613 ATP binding site [chemical binding]; other site 512565006614 Q-loop/lid; other site 512565006615 ABC transporter signature motif; other site 512565006616 Walker B; other site 512565006617 D-loop; other site 512565006618 H-loop/switch region; other site 512565006619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006621 active site 512565006622 phosphorylation site [posttranslational modification] 512565006623 intermolecular recognition site; other site 512565006624 dimerization interface [polypeptide binding]; other site 512565006625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006626 DNA binding residues [nucleotide binding] 512565006627 dimerization interface [polypeptide binding]; other site 512565006628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565006629 Histidine kinase; Region: HisKA_3; pfam07730 512565006630 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565006631 Protein of unknown function, DUF488; Region: DUF488; pfam04343 512565006632 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512565006633 homotrimer interaction site [polypeptide binding]; other site 512565006634 putative active site [active] 512565006635 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565006636 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565006637 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 512565006638 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 512565006639 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 512565006640 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 512565006641 Short repeats of unknown function; Region: ALF; pfam03752 512565006642 Short repeats of unknown function; Region: ALF; pfam03752 512565006643 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 512565006644 protein-splicing catalytic site; other site 512565006645 thioester formation/cholesterol transfer; other site 512565006646 Pretoxin HINT domain; Region: PT-HINT; pfam07591 512565006647 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565006648 active site 512565006649 substrate binding sites [chemical binding]; other site 512565006650 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565006651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565006652 DNA binding site [nucleotide binding] 512565006653 domain linker motif; other site 512565006654 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565006655 dimerization interface [polypeptide binding]; other site 512565006656 ligand binding site [chemical binding]; other site 512565006657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565006658 dimer interface [polypeptide binding]; other site 512565006659 conserved gate region; other site 512565006660 putative PBP binding loops; other site 512565006661 ABC-ATPase subunit interface; other site 512565006662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565006663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565006664 dimer interface [polypeptide binding]; other site 512565006665 conserved gate region; other site 512565006666 putative PBP binding loops; other site 512565006667 ABC-ATPase subunit interface; other site 512565006668 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565006669 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 512565006670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565006671 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565006672 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565006673 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565006674 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 512565006675 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 512565006676 beta-galactosidase; Region: BGL; TIGR03356 512565006677 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 512565006678 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 512565006679 substrate binding pocket [chemical binding]; other site 512565006680 catalytic triad [active] 512565006681 hypothetical protein; Provisional; Region: PRK07236 512565006682 hypothetical protein; Validated; Region: PRK05868 512565006683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565006684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565006685 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 512565006686 putative dimerization interface [polypeptide binding]; other site 512565006687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565006688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565006689 metal binding site [ion binding]; metal-binding site 512565006690 active site 512565006691 I-site; other site 512565006692 RHS Repeat; Region: RHS_repeat; pfam05593 512565006693 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 512565006694 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565006695 RHS Repeat; Region: RHS_repeat; cl11982 512565006696 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 512565006697 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565006698 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 512565006699 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 512565006700 protein-splicing catalytic site; other site 512565006701 thioester formation/cholesterol transfer; other site 512565006702 Pretoxin HINT domain; Region: PT-HINT; pfam07591 512565006703 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 512565006704 active site 512565006705 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 512565006706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006708 active site 512565006709 phosphorylation site [posttranslational modification] 512565006710 intermolecular recognition site; other site 512565006711 dimerization interface [polypeptide binding]; other site 512565006712 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006713 DNA binding residues [nucleotide binding] 512565006714 dimerization interface [polypeptide binding]; other site 512565006715 Putative sensor; Region: Sensor; pfam13796 512565006716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565006717 Histidine kinase; Region: HisKA_3; pfam07730 512565006718 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 512565006719 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 512565006720 VanW like protein; Region: VanW; pfam04294 512565006721 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565006722 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565006723 putative NAD(P) binding site [chemical binding]; other site 512565006724 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 512565006725 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 512565006726 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565006727 ig-like, plexins, transcription factors; Region: IPT; smart00429 512565006728 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 512565006729 Predicted flavoprotein [General function prediction only]; Region: COG0431 512565006730 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565006731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565006732 MarR family; Region: MarR_2; pfam12802 512565006733 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 512565006734 short chain dehydrogenase; Provisional; Region: PRK06197 512565006735 Predicted ATPase [General function prediction only]; Region: COG3910 512565006736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565006737 Walker A/P-loop; other site 512565006738 ATP binding site [chemical binding]; other site 512565006739 Q-loop/lid; other site 512565006740 ABC transporter signature motif; other site 512565006741 Walker B; other site 512565006742 D-loop; other site 512565006743 H-loop/switch region; other site 512565006744 hypothetical protein; Provisional; Region: PRK06834 512565006745 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565006746 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565006747 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006748 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 512565006749 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 512565006750 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565006751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565006752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565006753 Walker A/P-loop; other site 512565006754 ATP binding site [chemical binding]; other site 512565006755 Q-loop/lid; other site 512565006756 ABC transporter signature motif; other site 512565006757 Walker B; other site 512565006758 D-loop; other site 512565006759 H-loop/switch region; other site 512565006760 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565006761 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565006762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565006763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565006764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565006765 Histidine kinase; Region: HisKA_3; pfam07730 512565006766 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565006767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006769 active site 512565006770 phosphorylation site [posttranslational modification] 512565006771 intermolecular recognition site; other site 512565006772 dimerization interface [polypeptide binding]; other site 512565006773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006774 DNA binding residues [nucleotide binding] 512565006775 dimerization interface [polypeptide binding]; other site 512565006776 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565006777 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565006778 Walker A/P-loop; other site 512565006779 ATP binding site [chemical binding]; other site 512565006780 Q-loop/lid; other site 512565006781 ABC transporter signature motif; other site 512565006782 Walker B; other site 512565006783 D-loop; other site 512565006784 H-loop/switch region; other site 512565006785 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565006786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006787 active site 512565006788 phosphorylation site [posttranslational modification] 512565006789 intermolecular recognition site; other site 512565006790 dimerization interface [polypeptide binding]; other site 512565006791 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565006792 DNA binding site [nucleotide binding] 512565006793 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565006794 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 512565006795 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 512565006796 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512565006797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006798 Response regulator receiver domain; Region: Response_reg; pfam00072 512565006799 active site 512565006800 phosphorylation site [posttranslational modification] 512565006801 intermolecular recognition site; other site 512565006802 dimerization interface [polypeptide binding]; other site 512565006803 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 512565006804 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 512565006805 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 512565006806 dimer interface [polypeptide binding]; other site 512565006807 putative anticodon binding site; other site 512565006808 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565006809 motif 1; other site 512565006810 dimer interface [polypeptide binding]; other site 512565006811 active site 512565006812 motif 2; other site 512565006813 motif 3; other site 512565006814 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565006815 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565006816 NodB motif; other site 512565006817 active site 512565006818 catalytic site [active] 512565006819 metal binding site [ion binding]; metal-binding site 512565006820 Putative esterase; Region: Esterase; pfam00756 512565006821 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 512565006822 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565006823 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565006824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565006825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006826 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565006827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006828 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 512565006829 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565006830 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 512565006831 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 512565006832 NAD(P) binding site [chemical binding]; other site 512565006833 catalytic residues [active] 512565006834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565006835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006836 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 512565006837 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 512565006838 NAD binding site [chemical binding]; other site 512565006839 catalytic Zn binding site [ion binding]; other site 512565006840 substrate binding site [chemical binding]; other site 512565006841 structural Zn binding site [ion binding]; other site 512565006842 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512565006843 active site 512565006844 thiolase; Provisional; Region: PRK06158 512565006845 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 512565006846 active site 512565006847 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 512565006848 DUF35 OB-fold domain; Region: DUF35; pfam01796 512565006849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565006850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565006852 NAD(P) binding site [chemical binding]; other site 512565006853 active site 512565006854 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565006855 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565006856 active site 512565006857 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 512565006858 CoA binding domain; Region: CoA_binding_2; pfam13380 512565006859 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 512565006860 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 512565006861 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565006862 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 512565006863 dimer interaction site [polypeptide binding]; other site 512565006864 substrate-binding tunnel; other site 512565006865 active site 512565006866 catalytic site [active] 512565006867 substrate binding site [chemical binding]; other site 512565006868 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565006869 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565006870 metal binding site [ion binding]; metal-binding site 512565006871 active site 512565006872 I-site; other site 512565006873 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565006874 Helix-turn-helix domain; Region: HTH_18; pfam12833 512565006875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565006876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565006877 putative substrate translocation pore; other site 512565006878 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 512565006879 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 512565006880 Probable Catalytic site; other site 512565006881 metal-binding site 512565006882 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 512565006883 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 512565006884 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512565006885 phosphate binding site [ion binding]; other site 512565006886 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 512565006887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565006888 FeS/SAM binding site; other site 512565006889 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 512565006890 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 512565006891 mycofactocin precursor; Region: mycofactocin; TIGR03969 512565006892 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565006893 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 512565006894 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565006895 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 512565006896 classical (c) SDRs; Region: SDR_c; cd05233 512565006897 NAD(P) binding site [chemical binding]; other site 512565006898 active site 512565006899 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 512565006900 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565006901 inhibitor-cofactor binding pocket; inhibition site 512565006902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565006903 catalytic residue [active] 512565006904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565006905 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565006906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565006907 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565006908 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 512565006909 Cytochrome P450; Region: p450; cl12078 512565006910 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565006911 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 512565006912 classical (c) SDRs; Region: SDR_c; cd05233 512565006913 NAD(P) binding site [chemical binding]; other site 512565006914 active site 512565006915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565006916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565006918 putative substrate translocation pore; other site 512565006919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565006920 hypothetical protein; Provisional; Region: PRK07236 512565006921 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 512565006922 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 512565006923 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 512565006924 active site 512565006925 MMPL family; Region: MMPL; pfam03176 512565006926 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565006927 Bacterial Ig-like domain; Region: Big_5; pfam13205 512565006928 haloalkane dehalogenase; Provisional; Region: PRK03592 512565006929 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 512565006930 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565006931 MarR family; Region: MarR; pfam01047 512565006932 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565006933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565006934 active site 512565006935 phosphorylation site [posttranslational modification] 512565006936 intermolecular recognition site; other site 512565006937 dimerization interface [polypeptide binding]; other site 512565006938 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565006939 DNA binding residues [nucleotide binding] 512565006940 dimerization interface [polypeptide binding]; other site 512565006941 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565006942 Histidine kinase; Region: HisKA_3; pfam07730 512565006943 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565006944 ATP binding site [chemical binding]; other site 512565006945 Mg2+ binding site [ion binding]; other site 512565006946 G-X-G motif; other site 512565006947 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 512565006948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565006949 Walker A/P-loop; other site 512565006950 ATP binding site [chemical binding]; other site 512565006951 Q-loop/lid; other site 512565006952 ABC transporter signature motif; other site 512565006953 Walker B; other site 512565006954 D-loop; other site 512565006955 H-loop/switch region; other site 512565006956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565006957 dimerization interface [polypeptide binding]; other site 512565006958 putative DNA binding site [nucleotide binding]; other site 512565006959 putative Zn2+ binding site [ion binding]; other site 512565006960 RibD C-terminal domain; Region: RibD_C; cl17279 512565006961 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565006962 hydrophobic ligand binding site; other site 512565006963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565006964 MarR family; Region: MarR_2; pfam12802 512565006965 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565006966 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565006967 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 512565006968 active site 512565006969 catalytic residues [active] 512565006970 DNA binding site [nucleotide binding] 512565006971 Int/Topo IB signature motif; other site 512565006972 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 512565006973 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 512565006974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512565006975 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565006976 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565006977 Secretory lipase; Region: LIP; pfam03583 512565006978 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 512565006979 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 512565006980 hypothetical protein; Provisional; Region: PRK07236 512565006981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565006982 MarR family; Region: MarR_2; pfam12802 512565006983 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 512565006984 putative metal binding site [ion binding]; other site 512565006985 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 512565006986 putative metal binding site [ion binding]; other site 512565006987 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 512565006988 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 512565006989 active site 512565006990 catalytic site [active] 512565006991 TPR repeat; Region: TPR_11; pfam13414 512565006992 TPR repeat; Region: TPR_11; pfam13414 512565006993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565006994 binding surface 512565006995 TPR motif; other site 512565006996 TPR repeat; Region: TPR_11; pfam13414 512565006997 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565006998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565006999 binding surface 512565007000 TPR motif; other site 512565007001 TPR repeat; Region: TPR_11; pfam13414 512565007002 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565007003 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565007004 active site 512565007005 ATP binding site [chemical binding]; other site 512565007006 substrate binding site [chemical binding]; other site 512565007007 activation loop (A-loop); other site 512565007008 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565007009 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565007010 structural tetrad; other site 512565007011 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565007012 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565007013 structural tetrad; other site 512565007014 Excalibur calcium-binding domain; Region: Excalibur; cl05460 512565007015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565007016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565007017 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 512565007018 dimerization interface [polypeptide binding]; other site 512565007019 substrate binding pocket [chemical binding]; other site 512565007020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565007021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007022 WHG domain; Region: WHG; pfam13305 512565007023 SnoaL-like domain; Region: SnoaL_2; pfam12680 512565007024 Domain of unknown function (DUF427); Region: DUF427; pfam04248 512565007025 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 512565007026 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 512565007027 putative active site [active] 512565007028 catalytic site [active] 512565007029 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 512565007030 putative active site [active] 512565007031 catalytic site [active] 512565007032 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565007033 sugar binding site [chemical binding]; other site 512565007034 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 512565007035 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 512565007036 potential frameshift: common BLAST hit: gi|119962079|ref|YP_946843.1| helix-turn-helix domain-containing protein 512565007037 Cupin domain; Region: Cupin_2; pfam07883 512565007038 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565007039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007040 dimerization interface [polypeptide binding]; other site 512565007041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565007042 dimer interface [polypeptide binding]; other site 512565007043 putative CheW interface [polypeptide binding]; other site 512565007044 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 512565007045 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565007046 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565007047 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565007048 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565007049 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565007050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565007051 putative PBP binding loops; other site 512565007052 dimer interface [polypeptide binding]; other site 512565007053 ABC-ATPase subunit interface; other site 512565007054 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565007055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565007056 dimer interface [polypeptide binding]; other site 512565007057 conserved gate region; other site 512565007058 putative PBP binding loops; other site 512565007059 ABC-ATPase subunit interface; other site 512565007060 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 512565007061 dihydroxy-acid dehydratase; Validated; Region: PRK06131 512565007062 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565007063 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565007064 metal binding site [ion binding]; metal-binding site 512565007065 active site 512565007066 I-site; other site 512565007067 alpha-galactosidase; Region: PLN02808; cl17638 512565007068 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565007069 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007070 putative sugar binding sites [chemical binding]; other site 512565007071 Q-X-W motif; other site 512565007072 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 512565007073 active site 512565007074 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 512565007075 PaaX-like protein; Region: PaaX; pfam07848 512565007076 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 512565007077 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 512565007078 substrate binding site [chemical binding]; other site 512565007079 active site 512565007080 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565007081 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007082 putative sugar binding sites [chemical binding]; other site 512565007083 Q-X-W motif; other site 512565007084 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 512565007085 active site 512565007086 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565007087 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565007088 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565007089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565007090 substrate binding site [chemical binding]; other site 512565007091 oxyanion hole (OAH) forming residues; other site 512565007092 trimer interface [polypeptide binding]; other site 512565007093 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 512565007094 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565007095 intersubunit interface [polypeptide binding]; other site 512565007096 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 512565007097 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512565007098 dimer interface [polypeptide binding]; other site 512565007099 putative PBP binding regions; other site 512565007100 ABC-ATPase subunit interface; other site 512565007101 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 512565007102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565007103 Walker A/P-loop; other site 512565007104 ATP binding site [chemical binding]; other site 512565007105 Q-loop/lid; other site 512565007106 ABC transporter signature motif; other site 512565007107 Walker B; other site 512565007108 D-loop; other site 512565007109 H-loop/switch region; other site 512565007110 PQQ-like domain; Region: PQQ_2; pfam13360 512565007111 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 512565007112 Ca binding site [ion binding]; other site 512565007113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 512565007114 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 512565007115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565007116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565007117 dimer interface [polypeptide binding]; other site 512565007118 conserved gate region; other site 512565007119 putative PBP binding loops; other site 512565007120 ABC-ATPase subunit interface; other site 512565007121 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512565007122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565007123 dimer interface [polypeptide binding]; other site 512565007124 conserved gate region; other site 512565007125 putative PBP binding loops; other site 512565007126 ABC-ATPase subunit interface; other site 512565007127 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565007128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565007129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565007130 DNA binding site [nucleotide binding] 512565007131 domain linker motif; other site 512565007132 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565007133 dimerization interface [polypeptide binding]; other site 512565007134 ligand binding site [chemical binding]; other site 512565007135 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565007136 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512565007137 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 512565007138 putative metal binding site [ion binding]; other site 512565007139 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 512565007140 Ca binding site [ion binding]; other site 512565007141 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 512565007142 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512565007143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565007144 ABC-ATPase subunit interface; other site 512565007145 dimer interface [polypeptide binding]; other site 512565007146 putative PBP binding regions; other site 512565007147 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 512565007148 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 512565007149 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 512565007150 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565007151 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 512565007152 intersubunit interface [polypeptide binding]; other site 512565007153 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 512565007154 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565007155 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 512565007156 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 512565007157 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 512565007158 WxL domain surface cell wall-binding; Region: WxL; pfam13731 512565007159 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 512565007160 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 512565007161 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 512565007162 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 512565007163 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565007164 Transcriptional regulator PadR-like family; Region: PadR; cl17335 512565007165 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 512565007166 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565007167 Cellulose binding domain; Region: CBM_2; cl17741 512565007168 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 512565007169 CBD_II domain; Region: CBD_II; smart00637 512565007170 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 512565007171 active site 512565007172 catalytic triad [active] 512565007173 oxyanion hole [active] 512565007174 Ricin-type beta-trefoil; Region: RICIN; smart00458 512565007175 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007176 putative sugar binding sites [chemical binding]; other site 512565007177 Q-X-W motif; other site 512565007178 alpha-galactosidase; Region: PLN02808; cl17638 512565007179 Ricin-type beta-trefoil; Region: RICIN; smart00458 512565007180 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007181 putative sugar binding sites [chemical binding]; other site 512565007182 Q-X-W motif; other site 512565007183 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 512565007184 substrate binding site [chemical binding]; other site 512565007185 active site 512565007186 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 512565007187 metal binding site [ion binding]; metal-binding site 512565007188 ligand binding site [chemical binding]; other site 512565007189 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565007190 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007191 putative sugar binding sites [chemical binding]; other site 512565007192 Q-X-W motif; other site 512565007193 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 512565007194 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 512565007195 active site 512565007196 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007197 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565007198 putative sugar binding sites [chemical binding]; other site 512565007199 Q-X-W motif; other site 512565007200 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 512565007201 active site 512565007202 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 512565007203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565007204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007205 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565007206 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565007207 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 512565007208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565007209 putative DNA binding site [nucleotide binding]; other site 512565007210 putative Zn2+ binding site [ion binding]; other site 512565007211 NmrA-like family; Region: NmrA; pfam05368 512565007212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007213 NAD(P) binding site [chemical binding]; other site 512565007214 active site 512565007215 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565007216 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565007217 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 512565007218 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts; Region: FAS1; smart00554 512565007219 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565007220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565007221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565007222 DNA binding residues [nucleotide binding] 512565007223 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565007224 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565007225 FtsX-like permease family; Region: FtsX; pfam02687 512565007226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565007227 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565007228 Walker A/P-loop; other site 512565007229 ATP binding site [chemical binding]; other site 512565007230 Q-loop/lid; other site 512565007231 ABC transporter signature motif; other site 512565007232 Walker B; other site 512565007233 D-loop; other site 512565007234 H-loop/switch region; other site 512565007235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565007236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565007237 metal binding site [ion binding]; metal-binding site 512565007238 active site 512565007239 I-site; other site 512565007240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565007241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565007242 active site 512565007243 catalytic tetrad [active] 512565007244 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565007245 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565007246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565007247 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565007248 Penicillin amidase; Region: Penicil_amidase; pfam01804 512565007249 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 512565007250 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 512565007251 active site 512565007252 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 512565007253 AAA ATPase domain; Region: AAA_16; pfam13191 512565007254 Ras GTPase Activating Domain; Region: RasGAP; cl02569 512565007255 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 512565007256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565007257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007258 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 512565007259 Fatty acid desaturase; Region: FA_desaturase; pfam00487 512565007260 Di-iron ligands [ion binding]; other site 512565007261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565007262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007263 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 512565007264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565007265 putative substrate translocation pore; other site 512565007266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007267 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565007268 NAD(P) binding site [chemical binding]; other site 512565007269 active site 512565007270 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 512565007271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565007272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565007273 DNA binding residues [nucleotide binding] 512565007274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565007276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565007277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565007278 hypothetical protein; Provisional; Region: PRK06184 512565007279 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565007280 RibD C-terminal domain; Region: RibD_C; cl17279 512565007281 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512565007282 uridine kinase; Validated; Region: PRK06696 512565007283 active site 512565007284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007286 DNA binding residues [nucleotide binding] 512565007287 dimerization interface [polypeptide binding]; other site 512565007288 Pectate lyase; Region: Pectate_lyase; pfam03211 512565007289 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 512565007290 NlpC/P60 family; Region: NLPC_P60; pfam00877 512565007291 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 512565007292 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 512565007293 putative active site [active] 512565007294 metal binding site [ion binding]; metal-binding site 512565007295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007296 Response regulator receiver domain; Region: Response_reg; pfam00072 512565007297 active site 512565007298 phosphorylation site [posttranslational modification] 512565007299 intermolecular recognition site; other site 512565007300 dimerization interface [polypeptide binding]; other site 512565007301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007302 Response regulator receiver domain; Region: Response_reg; pfam00072 512565007303 active site 512565007304 phosphorylation site [posttranslational modification] 512565007305 intermolecular recognition site; other site 512565007306 dimerization interface [polypeptide binding]; other site 512565007307 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 512565007308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007309 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565007310 NAD(P) binding site [chemical binding]; other site 512565007311 active site 512565007312 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 512565007313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565007314 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 512565007315 Homeodomain-like domain; Region: HTH_23; cl17451 512565007316 Winged helix-turn helix; Region: HTH_29; pfam13551 512565007317 Integrase core domain; Region: rve; pfam00665 512565007318 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 512565007319 Integrase core domain; Region: rve_3; pfam13683 512565007320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565007321 dimerization interface [polypeptide binding]; other site 512565007322 putative DNA binding site [nucleotide binding]; other site 512565007323 putative Zn2+ binding site [ion binding]; other site 512565007324 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565007325 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565007326 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565007327 dimerization interface [polypeptide binding]; other site 512565007328 putative DNA binding site [nucleotide binding]; other site 512565007329 putative Zn2+ binding site [ion binding]; other site 512565007330 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 512565007331 active site 512565007332 catalytic triad [active] 512565007333 oxyanion hole [active] 512565007334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007335 dimerization interface [polypeptide binding]; other site 512565007336 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565007337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007338 dimerization interface [polypeptide binding]; other site 512565007339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007340 dimerization interface [polypeptide binding]; other site 512565007341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007342 dimerization interface [polypeptide binding]; other site 512565007343 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565007344 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007345 dimerization interface [polypeptide binding]; other site 512565007346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007347 dimerization interface [polypeptide binding]; other site 512565007348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007349 dimerization interface [polypeptide binding]; other site 512565007350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007351 dimerization interface [polypeptide binding]; other site 512565007352 GAF domain; Region: GAF_2; pfam13185 512565007353 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565007354 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 512565007355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007356 ATP binding site [chemical binding]; other site 512565007357 Mg2+ binding site [ion binding]; other site 512565007358 G-X-G motif; other site 512565007359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007360 phosphorylation site [posttranslational modification] 512565007361 intermolecular recognition site; other site 512565007362 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565007363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007364 active site 512565007365 phosphorylation site [posttranslational modification] 512565007366 intermolecular recognition site; other site 512565007367 dimerization interface [polypeptide binding]; other site 512565007368 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 512565007369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565007370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565007371 DNA binding residues [nucleotide binding] 512565007372 Putative zinc-finger; Region: zf-HC2; pfam13490 512565007373 Anti-sigma-K factor rskA; Region: RskA; pfam10099 512565007374 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 512565007375 Fasciclin domain; Region: Fasciclin; pfam02469 512565007376 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 512565007377 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 512565007378 Moco binding site; other site 512565007379 metal coordination site [ion binding]; other site 512565007380 dimerization interface [polypeptide binding]; other site 512565007381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 512565007383 active site 512565007384 phosphorylation site [posttranslational modification] 512565007385 intermolecular recognition site; other site 512565007386 dimerization interface [polypeptide binding]; other site 512565007387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007388 DNA binding residues [nucleotide binding] 512565007389 Putative sensor; Region: Sensor; pfam13796 512565007390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565007391 Histidine kinase; Region: HisKA_3; pfam07730 512565007392 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565007393 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565007394 FtsX-like permease family; Region: FtsX; pfam02687 512565007395 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565007396 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565007397 Walker A/P-loop; other site 512565007398 ATP binding site [chemical binding]; other site 512565007399 Q-loop/lid; other site 512565007400 ABC transporter signature motif; other site 512565007401 Walker B; other site 512565007402 D-loop; other site 512565007403 H-loop/switch region; other site 512565007404 GAF domain; Region: GAF; pfam01590 512565007405 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565007406 Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ERO1; COG5061 512565007407 PilZ domain; Region: PilZ; pfam07238 512565007408 CopC domain; Region: CopC; pfam04234 512565007409 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 512565007410 Protein of unknown function (DUF461); Region: DUF461; pfam04314 512565007411 Copper resistance protein D; Region: CopD; cl00563 512565007412 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 512565007413 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 512565007414 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565007415 intersubunit interface [polypeptide binding]; other site 512565007416 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565007417 FecCD transport family; Region: FecCD; pfam01032 512565007418 ABC-ATPase subunit interface; other site 512565007419 dimer interface [polypeptide binding]; other site 512565007420 putative PBP binding regions; other site 512565007421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565007422 ABC-ATPase subunit interface; other site 512565007423 dimer interface [polypeptide binding]; other site 512565007424 putative PBP binding regions; other site 512565007425 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565007426 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565007427 Walker A/P-loop; other site 512565007428 ATP binding site [chemical binding]; other site 512565007429 Q-loop/lid; other site 512565007430 ABC transporter signature motif; other site 512565007431 Walker B; other site 512565007432 D-loop; other site 512565007433 H-loop/switch region; other site 512565007434 tartrate dehydrogenase; Provisional; Region: PRK08194 512565007435 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 512565007436 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 512565007437 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565007438 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565007439 putative sugar binding sites [chemical binding]; other site 512565007440 Q-X-W motif; other site 512565007441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565007442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565007443 Walker A/P-loop; other site 512565007444 ATP binding site [chemical binding]; other site 512565007445 Q-loop/lid; other site 512565007446 ABC transporter signature motif; other site 512565007447 Walker B; other site 512565007448 D-loop; other site 512565007449 H-loop/switch region; other site 512565007450 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 512565007451 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565007452 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565007453 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565007454 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565007455 putative NAD(P) binding site [chemical binding]; other site 512565007456 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565007457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565007458 Histidine kinase; Region: HisKA_3; pfam07730 512565007459 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565007460 ATP binding site [chemical binding]; other site 512565007461 Mg2+ binding site [ion binding]; other site 512565007462 G-X-G motif; other site 512565007463 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007465 active site 512565007466 phosphorylation site [posttranslational modification] 512565007467 intermolecular recognition site; other site 512565007468 dimerization interface [polypeptide binding]; other site 512565007469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007470 DNA binding residues [nucleotide binding] 512565007471 dimerization interface [polypeptide binding]; other site 512565007472 AAA ATPase domain; Region: AAA_16; pfam13191 512565007473 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007475 DNA binding residues [nucleotide binding] 512565007476 dimerization interface [polypeptide binding]; other site 512565007477 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007479 DNA binding residues [nucleotide binding] 512565007480 dimerization interface [polypeptide binding]; other site 512565007481 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 512565007482 FMN binding site [chemical binding]; other site 512565007483 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 512565007484 dimer interface [polypeptide binding]; other site 512565007485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565007486 S-adenosylmethionine binding site [chemical binding]; other site 512565007487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 512565007488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 512565007489 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565007490 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 512565007491 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565007492 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565007493 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 512565007494 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565007495 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565007496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007497 NAD(P) binding site [chemical binding]; other site 512565007498 active site 512565007499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007500 active site 512565007501 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565007502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565007503 DNA binding site [nucleotide binding] 512565007504 domain linker motif; other site 512565007505 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565007506 HTH domain; Region: HTH_11; pfam08279 512565007507 Predicted transcriptional regulator [Transcription]; Region: COG2378 512565007508 WYL domain; Region: WYL; pfam13280 512565007509 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 512565007510 dimer interface [polypeptide binding]; other site 512565007511 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565007512 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565007513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565007514 dimer interface [polypeptide binding]; other site 512565007515 putative CheW interface [polypeptide binding]; other site 512565007516 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565007517 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565007518 DDE superfamily endonuclease; Region: DDE_5; pfam13546 512565007519 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 512565007520 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 512565007521 Transcriptional regulators [Transcription]; Region: GntR; COG1802 512565007522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565007523 DNA-binding site [nucleotide binding]; DNA binding site 512565007524 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 512565007525 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 512565007526 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 512565007527 active site pocket [active] 512565007528 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565007529 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565007530 active site 512565007531 catalytic tetrad [active] 512565007532 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 512565007533 Amidohydrolase; Region: Amidohydro_2; pfam04909 512565007534 active site 512565007535 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 512565007536 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 512565007537 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 512565007538 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 512565007539 metal binding site [ion binding]; metal-binding site 512565007540 substrate binding pocket [chemical binding]; other site 512565007541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565007542 classical (c) SDRs; Region: SDR_c; cd05233 512565007543 NAD(P) binding site [chemical binding]; other site 512565007544 active site 512565007545 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565007546 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565007547 Transcriptional regulators [Transcription]; Region: GntR; COG1802 512565007548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565007549 DNA-binding site [nucleotide binding]; DNA binding site 512565007550 FCD domain; Region: FCD; pfam07729 512565007551 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565007552 active site 512565007553 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565007554 nudix motif; other site 512565007555 alpha-galactosidase; Region: PLN02808; cl17638 512565007556 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 512565007557 MarR family; Region: MarR_2; pfam12802 512565007558 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565007559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565007560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565007561 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512565007562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565007563 dimer interface [polypeptide binding]; other site 512565007564 conserved gate region; other site 512565007565 ABC-ATPase subunit interface; other site 512565007566 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565007567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565007568 dimer interface [polypeptide binding]; other site 512565007569 conserved gate region; other site 512565007570 putative PBP binding loops; other site 512565007571 ABC-ATPase subunit interface; other site 512565007572 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565007573 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 512565007574 active site 512565007575 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 512565007576 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 512565007577 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565007578 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565007579 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565007580 DNA binding residues [nucleotide binding] 512565007581 Trypsin; Region: Trypsin; pfam00089 512565007582 active site 512565007583 substrate binding sites [chemical binding]; other site 512565007584 Short repeats of unknown function; Region: ALF; pfam03752 512565007585 Short repeats of unknown function; Region: ALF; pfam03752 512565007586 Short repeats of unknown function; Region: ALF; pfam03752 512565007587 Short repeats of unknown function; Region: ALF; pfam03752 512565007588 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 512565007589 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 512565007590 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 512565007591 Melibiase; Region: Melibiase; pfam02065 512565007592 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565007593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565007594 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 512565007595 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 512565007596 Electron transfer DM13; Region: DM13; pfam10517 512565007597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565007598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007599 active site 512565007600 phosphorylation site [posttranslational modification] 512565007601 intermolecular recognition site; other site 512565007602 dimerization interface [polypeptide binding]; other site 512565007603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565007604 DNA binding site [nucleotide binding] 512565007605 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565007606 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007607 dimer interface [polypeptide binding]; other site 512565007608 phosphorylation site [posttranslational modification] 512565007609 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007610 ATP binding site [chemical binding]; other site 512565007611 Mg2+ binding site [ion binding]; other site 512565007612 G-X-G motif; other site 512565007613 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 512565007614 Response regulator receiver domain; Region: Response_reg; pfam00072 512565007615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007616 active site 512565007617 phosphorylation site [posttranslational modification] 512565007618 intermolecular recognition site; other site 512565007619 dimerization interface [polypeptide binding]; other site 512565007620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 512565007621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565007622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007623 dimer interface [polypeptide binding]; other site 512565007624 phosphorylation site [posttranslational modification] 512565007625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007626 ATP binding site [chemical binding]; other site 512565007627 Mg2+ binding site [ion binding]; other site 512565007628 G-X-G motif; other site 512565007629 Sporulation and spore germination; Region: Germane; cl11253 512565007630 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 512565007631 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565007632 anti sigma factor interaction site; other site 512565007633 regulatory phosphorylation site [posttranslational modification]; other site 512565007634 BON domain; Region: BON; pfam04972 512565007635 high affinity sulphate transporter 1; Region: sulP; TIGR00815 512565007636 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 512565007637 Sulfate transporter family; Region: Sulfate_transp; pfam00916 512565007638 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 512565007639 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 512565007640 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565007641 DNA binding residues [nucleotide binding] 512565007642 Transcriptional regulators [Transcription]; Region: FadR; COG2186 512565007643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565007644 DNA-binding site [nucleotide binding]; DNA binding site 512565007645 FCD domain; Region: FCD; pfam07729 512565007646 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 512565007647 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 512565007648 dimerization interface [polypeptide binding]; other site 512565007649 DPS ferroxidase diiron center [ion binding]; other site 512565007650 ion pore; other site 512565007651 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 512565007652 Verru_Chthon cassette protein D; Region: TIGR02596 512565007653 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 512565007654 Low molecular weight phosphatase family; Region: LMWPc; cl00105 512565007655 Chromate transporter; Region: Chromate_transp; pfam02417 512565007656 Chromate transporter; Region: Chromate_transp; pfam02417 512565007657 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565007658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565007659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565007660 DNA binding residues [nucleotide binding] 512565007661 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565007662 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565007663 ligand binding site [chemical binding]; other site 512565007664 flexible hinge region; other site 512565007665 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 512565007666 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 512565007667 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 512565007668 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565007669 DNA binding residues [nucleotide binding] 512565007670 drug binding residues [chemical binding]; other site 512565007671 dimer interface [polypeptide binding]; other site 512565007672 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 512565007673 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 512565007674 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565007675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565007676 dimerization interface [polypeptide binding]; other site 512565007677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007678 phosphorylation site [posttranslational modification] 512565007679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007680 ATP binding site [chemical binding]; other site 512565007681 G-X-G motif; other site 512565007682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565007683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007684 active site 512565007685 phosphorylation site [posttranslational modification] 512565007686 intermolecular recognition site; other site 512565007687 dimerization interface [polypeptide binding]; other site 512565007688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565007689 DNA binding site [nucleotide binding] 512565007690 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565007691 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 512565007692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565007693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007694 active site 512565007695 phosphorylation site [posttranslational modification] 512565007696 intermolecular recognition site; other site 512565007697 dimerization interface [polypeptide binding]; other site 512565007698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565007699 DNA binding site [nucleotide binding] 512565007700 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565007701 Cytochrome P450; Region: p450; cl12078 512565007702 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 512565007703 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 512565007704 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565007705 short chain dehydrogenase; Provisional; Region: PRK06940 512565007706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007707 NAD(P) binding site [chemical binding]; other site 512565007708 active site 512565007709 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565007710 substrate binding site [chemical binding]; other site 512565007711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565007712 Histidine kinase; Region: HisKA_3; pfam07730 512565007713 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565007714 ATP binding site [chemical binding]; other site 512565007715 Mg2+ binding site [ion binding]; other site 512565007716 G-X-G motif; other site 512565007717 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007719 active site 512565007720 phosphorylation site [posttranslational modification] 512565007721 intermolecular recognition site; other site 512565007722 dimerization interface [polypeptide binding]; other site 512565007723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007724 DNA binding residues [nucleotide binding] 512565007725 dimerization interface [polypeptide binding]; other site 512565007726 MMPL family; Region: MMPL; pfam03176 512565007727 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 512565007728 PAS domain S-box; Region: sensory_box; TIGR00229 512565007729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565007730 putative active site [active] 512565007731 heme pocket [chemical binding]; other site 512565007732 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565007733 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565007734 metal binding site [ion binding]; metal-binding site 512565007735 active site 512565007736 I-site; other site 512565007737 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565007738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565007739 metal binding site [ion binding]; metal-binding site 512565007740 active site 512565007741 I-site; other site 512565007742 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565007743 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 512565007744 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 512565007745 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565007746 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565007747 short chain dehydrogenase; Validated; Region: PRK08264 512565007748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007749 NAD(P) binding site [chemical binding]; other site 512565007750 active site 512565007751 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 512565007752 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565007753 DNA binding residues [nucleotide binding] 512565007754 putative dimer interface [polypeptide binding]; other site 512565007755 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 512565007756 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 512565007757 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 512565007758 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512565007759 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 512565007760 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 512565007761 Transposase domain (DUF772); Region: DUF772; pfam05598 512565007762 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 512565007763 hypothetical protein; Provisional; Region: PRK06753 512565007764 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565007765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 512565007766 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565007767 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565007768 putative catalytic site [active] 512565007769 putative phosphate binding site [ion binding]; other site 512565007770 putative metal binding site [ion binding]; other site 512565007771 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 512565007772 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565007773 Cellulose binding domain; Region: CBM_2; cl17741 512565007774 YcxB-like protein; Region: YcxB; pfam14317 512565007775 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 512565007776 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 512565007777 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 512565007778 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 512565007779 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 512565007780 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 512565007781 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512565007782 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 512565007783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565007784 motif II; other site 512565007785 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 512565007786 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565007787 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565007788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565007789 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 512565007790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565007791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565007792 DNA binding residues [nucleotide binding] 512565007793 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565007794 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565007795 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565007796 NodB motif; other site 512565007797 active site 512565007798 metal binding site [ion binding]; metal-binding site 512565007799 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 512565007800 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 512565007801 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 512565007802 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512565007803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565007804 Coenzyme A binding pocket [chemical binding]; other site 512565007805 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 512565007806 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565007807 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565007808 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 512565007809 short chain dehydrogenase; Provisional; Region: PRK06180 512565007810 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 512565007811 NADP binding site [chemical binding]; other site 512565007812 active site 512565007813 steroid binding site; other site 512565007814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565007815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007816 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512565007817 active site 512565007818 catalytic triad [active] 512565007819 oxyanion hole [active] 512565007820 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565007821 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 512565007822 active site 512565007823 ATP binding site [chemical binding]; other site 512565007824 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565007825 substrate binding site [chemical binding]; other site 512565007826 activation loop (A-loop); other site 512565007827 Predicted ATPase [General function prediction only]; Region: COG3899 512565007828 AAA ATPase domain; Region: AAA_16; pfam13191 512565007829 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565007830 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565007831 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565007832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565007833 putative active site [active] 512565007834 heme pocket [chemical binding]; other site 512565007835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007836 dimer interface [polypeptide binding]; other site 512565007837 phosphorylation site [posttranslational modification] 512565007838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007839 ATP binding site [chemical binding]; other site 512565007840 Mg2+ binding site [ion binding]; other site 512565007841 G-X-G motif; other site 512565007842 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565007843 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565007844 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 512565007845 cleavage site 512565007846 active site 512565007847 substrate binding sites [chemical binding]; other site 512565007848 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 512565007849 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 512565007850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565007851 active site 512565007852 nucleotide binding site [chemical binding]; other site 512565007853 HIGH motif; other site 512565007854 KMSKS motif; other site 512565007855 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565007856 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565007857 putative acyl-acceptor binding pocket; other site 512565007858 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565007859 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565007860 Walker A/P-loop; other site 512565007861 ATP binding site [chemical binding]; other site 512565007862 Q-loop/lid; other site 512565007863 ABC transporter signature motif; other site 512565007864 Walker B; other site 512565007865 D-loop; other site 512565007866 H-loop/switch region; other site 512565007867 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565007868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565007869 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565007870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565007871 S-adenosylmethionine binding site [chemical binding]; other site 512565007872 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 512565007873 NMT1/THI5 like; Region: NMT1; pfam09084 512565007874 membrane-bound complex binding site; other site 512565007875 hinge residues; other site 512565007876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565007877 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 512565007878 putative active site [active] 512565007879 heme pocket [chemical binding]; other site 512565007880 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565007881 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 512565007882 putative active site [active] 512565007883 heme pocket [chemical binding]; other site 512565007884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007885 dimer interface [polypeptide binding]; other site 512565007886 phosphorylation site [posttranslational modification] 512565007887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007888 ATP binding site [chemical binding]; other site 512565007889 Mg2+ binding site [ion binding]; other site 512565007890 G-X-G motif; other site 512565007891 Response regulator receiver domain; Region: Response_reg; pfam00072 512565007892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007893 active site 512565007894 phosphorylation site [posttranslational modification] 512565007895 intermolecular recognition site; other site 512565007896 dimerization interface [polypeptide binding]; other site 512565007897 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565007898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007899 dimer interface [polypeptide binding]; other site 512565007900 phosphorylation site [posttranslational modification] 512565007901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007902 ATP binding site [chemical binding]; other site 512565007903 Mg2+ binding site [ion binding]; other site 512565007904 G-X-G motif; other site 512565007905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007906 active site 512565007907 phosphorylation site [posttranslational modification] 512565007908 intermolecular recognition site; other site 512565007909 dimerization interface [polypeptide binding]; other site 512565007910 PAS domain S-box; Region: sensory_box; TIGR00229 512565007911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565007912 putative active site [active] 512565007913 heme pocket [chemical binding]; other site 512565007914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565007915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565007916 dimer interface [polypeptide binding]; other site 512565007917 phosphorylation site [posttranslational modification] 512565007918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565007919 ATP binding site [chemical binding]; other site 512565007920 Mg2+ binding site [ion binding]; other site 512565007921 G-X-G motif; other site 512565007922 Response regulator receiver domain; Region: Response_reg; pfam00072 512565007923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565007924 active site 512565007925 phosphorylation site [posttranslational modification] 512565007926 intermolecular recognition site; other site 512565007927 dimerization interface [polypeptide binding]; other site 512565007928 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 512565007929 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565007930 Sulfate transporter family; Region: Sulfate_transp; pfam00916 512565007931 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 512565007932 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 512565007933 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 512565007934 putative dimer interface [polypeptide binding]; other site 512565007935 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 512565007936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565007937 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565007938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565007939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007940 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 512565007941 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 512565007942 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565007943 Ligand Binding Site [chemical binding]; other site 512565007944 FIST N domain; Region: FIST; pfam08495 512565007945 FIST C domain; Region: FIST_C; pfam10442 512565007946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565007947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565007948 metal binding site [ion binding]; metal-binding site 512565007949 active site 512565007950 I-site; other site 512565007951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565007952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565007953 S-adenosylmethionine binding site [chemical binding]; other site 512565007954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565007955 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 512565007956 TPR motif; other site 512565007957 binding surface 512565007958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565007959 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565007960 AAA ATPase domain; Region: AAA_16; pfam13191 512565007961 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 512565007962 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565007963 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565007964 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 512565007965 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565007966 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 512565007967 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565007968 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 512565007969 TIR domain; Region: TIR_2; cl17458 512565007970 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565007971 structural tetrad; other site 512565007972 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565007973 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565007974 structural tetrad; other site 512565007975 potential frameshift: common BLAST hit: gi|315506644|ref|YP_004085531.1| transposase is4 family protein 512565007976 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565007977 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565007978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565007979 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565007980 NAD(P) binding site [chemical binding]; other site 512565007981 active site 512565007982 short chain dehydrogenase; Provisional; Region: PRK06500 512565007983 classical (c) SDRs; Region: SDR_c; cd05233 512565007984 NAD(P) binding site [chemical binding]; other site 512565007985 active site 512565007986 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 512565007987 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 512565007988 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565007989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565007990 AAA ATPase domain; Region: AAA_16; pfam13191 512565007991 WD domain, G-beta repeat; Region: WD40; pfam00400 512565007992 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565007993 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 512565007994 structural tetrad; other site 512565007995 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 512565007996 structural tetrad; other site 512565007997 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565007998 Cytochrome P450; Region: p450; cl12078 512565007999 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565008000 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565008001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565008002 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565008003 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 512565008004 oligomer interface [polypeptide binding]; other site 512565008005 Protein of unknown function DUF262; Region: DUF262; pfam03235 512565008006 Uncharacterized conserved protein [Function unknown]; Region: COG1479 512565008007 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 512565008008 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 512565008009 AAA domain; Region: AAA_17; cl17253 512565008010 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565008011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565008012 Mg2+ binding site [ion binding]; other site 512565008013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565008014 anti sigma factor interaction site; other site 512565008015 regulatory phosphorylation site [posttranslational modification]; other site 512565008016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565008017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565008018 salt bridge; other site 512565008019 non-specific DNA binding site [nucleotide binding]; other site 512565008020 sequence-specific DNA binding site [nucleotide binding]; other site 512565008021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 512565008022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565008023 NAD(P) binding site [chemical binding]; other site 512565008024 active site 512565008025 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 512565008026 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565008027 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 512565008028 putative NAD(P) binding site [chemical binding]; other site 512565008029 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 512565008030 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 512565008031 homodimer interface [polypeptide binding]; other site 512565008032 active site 512565008033 TDP-binding site; other site 512565008034 acceptor substrate-binding pocket; other site 512565008035 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565008036 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512565008037 RibD C-terminal domain; Region: RibD_C; cl17279 512565008038 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 512565008039 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 512565008040 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 512565008041 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 512565008042 Uncharacterized conserved protein [Function unknown]; Region: COG1262 512565008043 AAA ATPase domain; Region: AAA_16; pfam13191 512565008044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008046 dimerization interface [polypeptide binding]; other site 512565008047 DNA binding residues [nucleotide binding] 512565008048 AAA ATPase domain; Region: AAA_16; pfam13191 512565008049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008050 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008051 DNA binding residues [nucleotide binding] 512565008052 dimerization interface [polypeptide binding]; other site 512565008053 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008055 DNA binding residues [nucleotide binding] 512565008056 dimerization interface [polypeptide binding]; other site 512565008057 Homeodomain-like domain; Region: HTH_23; pfam13384 512565008058 Winged helix-turn helix; Region: HTH_29; pfam13551 512565008059 Homeodomain-like domain; Region: HTH_32; pfam13565 512565008060 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512565008061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 512565008062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512565008063 AAA ATPase domain; Region: AAA_16; pfam13191 512565008064 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008065 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008066 DNA binding residues [nucleotide binding] 512565008067 dimerization interface [polypeptide binding]; other site 512565008068 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565008069 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565008070 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565008071 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565008072 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565008073 MASE1; Region: MASE1; cl17823 512565008074 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565008075 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565008076 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565008077 anti sigma factor interaction site; other site 512565008078 regulatory phosphorylation site [posttranslational modification]; other site 512565008079 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565008080 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565008081 ATP binding site [chemical binding]; other site 512565008082 Mg2+ binding site [ion binding]; other site 512565008083 G-X-G motif; other site 512565008084 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565008085 anti sigma factor interaction site; other site 512565008086 regulatory phosphorylation site [posttranslational modification]; other site 512565008087 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 512565008088 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 512565008089 structural tetrad; other site 512565008090 PQQ-like domain; Region: PQQ_2; pfam13360 512565008091 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565008092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565008093 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 512565008094 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565008095 NAD binding site [chemical binding]; other site 512565008096 catalytic Zn binding site [ion binding]; other site 512565008097 structural Zn binding site [ion binding]; other site 512565008098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565008099 Coenzyme A binding pocket [chemical binding]; other site 512565008100 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565008101 cleavage site 512565008102 active site 512565008103 substrate binding sites [chemical binding]; other site 512565008104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565008105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565008106 active site 512565008107 phosphorylation site [posttranslational modification] 512565008108 intermolecular recognition site; other site 512565008109 dimerization interface [polypeptide binding]; other site 512565008110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565008111 DNA binding site [nucleotide binding] 512565008112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565008113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565008114 dimerization interface [polypeptide binding]; other site 512565008115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565008116 dimer interface [polypeptide binding]; other site 512565008117 phosphorylation site [posttranslational modification] 512565008118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565008119 ATP binding site [chemical binding]; other site 512565008120 Mg2+ binding site [ion binding]; other site 512565008121 G-X-G motif; other site 512565008122 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565008123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565008124 dimer interface [polypeptide binding]; other site 512565008125 putative CheW interface [polypeptide binding]; other site 512565008126 MepB protein; Region: MepB; cl01985 512565008127 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565008128 MarR family; Region: MarR_2; pfam12802 512565008129 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 512565008130 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565008131 Epoxide hydrolase N terminus; Region: EHN; pfam06441 512565008132 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 512565008133 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 512565008134 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565008135 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565008136 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565008137 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 512565008138 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565008139 Walker A/P-loop; other site 512565008140 ATP binding site [chemical binding]; other site 512565008141 Q-loop/lid; other site 512565008142 ABC transporter signature motif; other site 512565008143 Walker B; other site 512565008144 D-loop; other site 512565008145 H-loop/switch region; other site 512565008146 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 512565008147 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565008148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565008149 Walker A/P-loop; other site 512565008150 ATP binding site [chemical binding]; other site 512565008151 Q-loop/lid; other site 512565008152 ABC transporter signature motif; other site 512565008153 Walker B; other site 512565008154 D-loop; other site 512565008155 H-loop/switch region; other site 512565008156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 512565008157 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 512565008158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565008159 dimer interface [polypeptide binding]; other site 512565008160 ABC-ATPase subunit interface; other site 512565008161 putative PBP binding loops; other site 512565008162 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565008163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565008164 putative PBP binding loops; other site 512565008165 ABC-ATPase subunit interface; other site 512565008166 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 512565008167 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 512565008168 peptide binding site [polypeptide binding]; other site 512565008169 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565008170 transcriptional regulator BetI; Validated; Region: PRK00767 512565008171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008172 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 512565008173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565008174 DNA binding site [nucleotide binding] 512565008175 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 512565008176 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565008177 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 512565008178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565008179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565008180 homodimer interface [polypeptide binding]; other site 512565008181 catalytic residue [active] 512565008182 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 512565008183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565008184 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565008185 active site 512565008186 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 512565008187 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565008188 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 512565008189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565008190 putative DNA binding site [nucleotide binding]; other site 512565008191 putative Zn2+ binding site [ion binding]; other site 512565008192 AsnC family; Region: AsnC_trans_reg; pfam01037 512565008193 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 512565008194 active site 512565008195 dimer interface [polypeptide binding]; other site 512565008196 metal binding site [ion binding]; metal-binding site 512565008197 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 512565008198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565008199 active site 512565008200 motif I; other site 512565008201 motif II; other site 512565008202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565008203 NAD(P) binding site [chemical binding]; other site 512565008204 active site 512565008205 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 512565008206 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565008207 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 512565008208 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565008209 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565008210 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565008211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565008212 classical (c) SDRs; Region: SDR_c; cd05233 512565008213 NAD(P) binding site [chemical binding]; other site 512565008214 active site 512565008215 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 512565008216 Glucose dehydrogenase; Region: glucose_DH; cd08230 512565008217 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565008218 NADP binding site [chemical binding]; other site 512565008219 catalytic Zn binding site [ion binding]; other site 512565008220 structural Zn binding site [ion binding]; other site 512565008221 dimer interface [polypeptide binding]; other site 512565008222 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565008223 Cytochrome P450; Region: p450; cl12078 512565008224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565008225 S-adenosylmethionine binding site [chemical binding]; other site 512565008226 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565008227 hypothetical protein; Provisional; Region: PRK08244 512565008228 Domain of unknown function (DUF385); Region: DUF385; pfam04075 512565008229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565008230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565008231 putative substrate translocation pore; other site 512565008232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565008233 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 512565008234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565008235 Walker A/P-loop; other site 512565008236 ATP binding site [chemical binding]; other site 512565008237 Q-loop/lid; other site 512565008238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565008239 ABC transporter signature motif; other site 512565008240 Walker B; other site 512565008241 D-loop; other site 512565008242 H-loop/switch region; other site 512565008243 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565008244 Walker A/P-loop; other site 512565008245 ATP binding site [chemical binding]; other site 512565008246 Q-loop/lid; other site 512565008247 ABC transporter signature motif; other site 512565008248 Walker B; other site 512565008249 D-loop; other site 512565008250 H-loop/switch region; other site 512565008251 Uncharacterized conserved protein [Function unknown]; Region: COG2353 512565008252 acyl-CoA synthetase; Validated; Region: PRK05850 512565008253 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 512565008254 acyl-activating enzyme (AAE) consensus motif; other site 512565008255 active site 512565008256 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 512565008257 Condensation domain; Region: Condensation; pfam00668 512565008258 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565008259 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565008260 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565008261 acyl-activating enzyme (AAE) consensus motif; other site 512565008262 AMP binding site [chemical binding]; other site 512565008263 active site 512565008264 CoA binding site [chemical binding]; other site 512565008265 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565008266 Condensation domain; Region: Condensation; pfam00668 512565008267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565008268 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565008269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565008270 acyl-activating enzyme (AAE) consensus motif; other site 512565008271 AMP binding site [chemical binding]; other site 512565008272 active site 512565008273 CoA binding site [chemical binding]; other site 512565008274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565008275 Condensation domain; Region: Condensation; pfam00668 512565008276 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 512565008277 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565008278 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565008279 acyl-activating enzyme (AAE) consensus motif; other site 512565008280 AMP binding site [chemical binding]; other site 512565008281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565008282 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 512565008283 putative NAD(P) binding site [chemical binding]; other site 512565008284 active site 512565008285 putative substrate binding site [chemical binding]; other site 512565008286 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 512565008287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565008288 S-adenosylmethionine binding site [chemical binding]; other site 512565008289 MbtH-like protein; Region: MbtH; pfam03621 512565008290 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565008291 FAD binding domain; Region: FAD_binding_4; pfam01565 512565008292 Berberine and berberine like; Region: BBE; pfam08031 512565008293 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565008294 Peptidase family M28; Region: Peptidase_M28; pfam04389 512565008295 metal binding site [ion binding]; metal-binding site 512565008296 short chain dehydrogenase; Provisional; Region: PRK08303 512565008297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565008298 NAD(P) binding site [chemical binding]; other site 512565008299 active site 512565008300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565008301 TPR motif; other site 512565008302 binding surface 512565008303 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565008304 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 512565008305 acyl-activating enzyme (AAE) consensus motif; other site 512565008306 AMP binding site [chemical binding]; other site 512565008307 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565008308 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 512565008309 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 512565008310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565008311 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 512565008312 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 512565008313 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 512565008314 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 512565008315 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 512565008316 Right handed beta helix region; Region: Beta_helix; pfam13229 512565008317 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565008318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565008319 dimer interface [polypeptide binding]; other site 512565008320 conserved gate region; other site 512565008321 putative PBP binding loops; other site 512565008322 ABC-ATPase subunit interface; other site 512565008323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565008324 dimer interface [polypeptide binding]; other site 512565008325 conserved gate region; other site 512565008326 putative PBP binding loops; other site 512565008327 ABC-ATPase subunit interface; other site 512565008328 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565008329 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565008330 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 512565008331 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565008332 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565008333 putative sugar binding sites [chemical binding]; other site 512565008334 Q-X-W motif; other site 512565008335 HEAT repeats; Region: HEAT_2; pfam13646 512565008336 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 512565008337 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565008338 DNA binding residues [nucleotide binding] 512565008339 putative dimer interface [polypeptide binding]; other site 512565008340 HEAT repeats; Region: HEAT_2; pfam13646 512565008341 YCII-related domain; Region: YCII; cl00999 512565008342 pyridoxamine kinase; Validated; Region: PRK05756 512565008343 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 512565008344 dimer interface [polypeptide binding]; other site 512565008345 pyridoxal binding site [chemical binding]; other site 512565008346 ATP binding site [chemical binding]; other site 512565008347 YCII-related domain; Region: YCII; cl00999 512565008348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565008349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008350 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565008351 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008352 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 512565008353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565008354 NAD(P) binding site [chemical binding]; other site 512565008355 active site 512565008356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565008357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565008358 active site 512565008359 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 512565008360 Phosphotransferase enzyme family; Region: APH; pfam01636 512565008361 putative active site [active] 512565008362 putative substrate binding site [chemical binding]; other site 512565008363 ATP binding site [chemical binding]; other site 512565008364 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 512565008365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565008366 active site 512565008367 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 512565008368 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565008369 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 512565008370 active site 512565008371 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565008372 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565008373 active site 512565008374 metal binding site [ion binding]; metal-binding site 512565008375 Helix-turn-helix domain; Region: HTH_18; pfam12833 512565008376 Nitrate and nitrite sensing; Region: NIT; pfam08376 512565008377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565008378 ATP binding site [chemical binding]; other site 512565008379 Mg2+ binding site [ion binding]; other site 512565008380 G-X-G motif; other site 512565008381 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 512565008382 Protein of unknown function (DUF742); Region: DUF742; pfam05331 512565008383 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565008384 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 512565008385 G1 box; other site 512565008386 GTP/Mg2+ binding site [chemical binding]; other site 512565008387 G2 box; other site 512565008388 Switch I region; other site 512565008389 G3 box; other site 512565008390 Switch II region; other site 512565008391 G4 box; other site 512565008392 G5 box; other site 512565008393 Family description; Region: VCBS; pfam13517 512565008394 Family description; Region: VCBS; pfam13517 512565008395 Family description; Region: VCBS; pfam13517 512565008396 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565008397 Transcriptional regulator PadR-like family; Region: PadR; cl17335 512565008398 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 512565008399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565008400 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 512565008401 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 512565008402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565008403 NAD(P) binding site [chemical binding]; other site 512565008404 active site 512565008405 Tubby C 2; Region: Tub_2; cl02043 512565008406 short chain dehydrogenase; Provisional; Region: PRK08267 512565008407 classical (c) SDRs; Region: SDR_c; cd05233 512565008408 NAD(P) binding site [chemical binding]; other site 512565008409 active site 512565008410 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565008411 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 512565008412 acyl-activating enzyme (AAE) consensus motif; other site 512565008413 AMP binding site [chemical binding]; other site 512565008414 active site 512565008415 CoA binding site [chemical binding]; other site 512565008416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565008417 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 512565008418 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565008419 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565008420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565008421 active site 512565008422 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 512565008423 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565008424 NAD(P) binding site [chemical binding]; other site 512565008425 catalytic residues [active] 512565008426 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565008427 Cytochrome P450; Region: p450; cl12078 512565008428 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565008429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565008430 putative substrate translocation pore; other site 512565008431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565008432 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 512565008433 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565008434 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 512565008435 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 512565008436 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 512565008437 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 512565008438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565008439 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 512565008440 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 512565008441 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 512565008442 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565008443 motif 1; other site 512565008444 dimer interface [polypeptide binding]; other site 512565008445 active site 512565008446 motif 2; other site 512565008447 motif 3; other site 512565008448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 512565008449 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 512565008450 Fic family protein [Function unknown]; Region: COG3177 512565008451 Fic/DOC family; Region: Fic; pfam02661 512565008452 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 512565008453 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565008454 DNA binding residues [nucleotide binding] 512565008455 dimer interface [polypeptide binding]; other site 512565008456 Uncharacterized protein family (UPF0253); Region: UPF0253; cl11640 512565008457 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565008458 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565008459 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 512565008460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565008461 Walker A/P-loop; other site 512565008462 ATP binding site [chemical binding]; other site 512565008463 Q-loop/lid; other site 512565008464 ABC transporter signature motif; other site 512565008465 Walker B; other site 512565008466 D-loop; other site 512565008467 H-loop/switch region; other site 512565008468 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 512565008469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565008470 salt bridge; other site 512565008471 non-specific DNA binding site [nucleotide binding]; other site 512565008472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565008473 sequence-specific DNA binding site [nucleotide binding]; other site 512565008474 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565008475 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 512565008476 putative NAD(P) binding site [chemical binding]; other site 512565008477 putative substrate binding site [chemical binding]; other site 512565008478 catalytic Zn binding site [ion binding]; other site 512565008479 structural Zn binding site [ion binding]; other site 512565008480 dimer interface [polypeptide binding]; other site 512565008481 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565008482 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 512565008483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008484 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565008485 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 512565008486 NAD(P) binding site [chemical binding]; other site 512565008487 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565008488 hydrophobic ligand binding site; other site 512565008489 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565008490 dimerization interface [polypeptide binding]; other site 512565008491 putative DNA binding site [nucleotide binding]; other site 512565008492 putative Zn2+ binding site [ion binding]; other site 512565008493 Cation efflux family; Region: Cation_efflux; cl00316 512565008494 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 512565008495 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 512565008496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565008497 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 512565008498 PAS domain S-box; Region: sensory_box; TIGR00229 512565008499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565008500 putative active site [active] 512565008501 heme pocket [chemical binding]; other site 512565008502 PAS domain S-box; Region: sensory_box; TIGR00229 512565008503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565008504 putative active site [active] 512565008505 heme pocket [chemical binding]; other site 512565008506 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 512565008507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565008508 putative active site [active] 512565008509 heme pocket [chemical binding]; other site 512565008510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565008511 dimer interface [polypeptide binding]; other site 512565008512 phosphorylation site [posttranslational modification] 512565008513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565008514 ATP binding site [chemical binding]; other site 512565008515 Mg2+ binding site [ion binding]; other site 512565008516 G-X-G motif; other site 512565008517 Response regulator receiver domain; Region: Response_reg; pfam00072 512565008518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565008519 active site 512565008520 phosphorylation site [posttranslational modification] 512565008521 intermolecular recognition site; other site 512565008522 dimerization interface [polypeptide binding]; other site 512565008523 Flavodoxin; Region: Flavodoxin_1; pfam00258 512565008524 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565008525 Ligand Binding Site [chemical binding]; other site 512565008526 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565008527 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 512565008528 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 512565008529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 512565008530 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565008531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565008532 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565008533 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 512565008534 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 512565008535 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 512565008536 active site 512565008537 putative catalytic site [active] 512565008538 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 512565008539 catalytic residues [active] 512565008540 dimer interface [polypeptide binding]; other site 512565008541 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 512565008542 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 512565008543 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 512565008544 ligand binding site [chemical binding]; other site 512565008545 active site 512565008546 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 512565008547 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 512565008548 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565008549 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565008550 catalytic residue [active] 512565008551 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 512565008552 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512565008553 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512565008554 Walker A/P-loop; other site 512565008555 ATP binding site [chemical binding]; other site 512565008556 Q-loop/lid; other site 512565008557 ABC transporter signature motif; other site 512565008558 Walker B; other site 512565008559 D-loop; other site 512565008560 H-loop/switch region; other site 512565008561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565008562 dimer interface [polypeptide binding]; other site 512565008563 conserved gate region; other site 512565008564 putative PBP binding loops; other site 512565008565 ABC-ATPase subunit interface; other site 512565008566 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512565008567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565008568 substrate binding pocket [chemical binding]; other site 512565008569 membrane-bound complex binding site; other site 512565008570 hinge residues; other site 512565008571 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 512565008572 catalytic triad [active] 512565008573 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565008574 Interdomain contacts; other site 512565008575 Cytokine receptor motif; other site 512565008576 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565008577 Interdomain contacts; other site 512565008578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 512565008579 Putative esterase; Region: Esterase; pfam00756 512565008580 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565008581 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565008582 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 512565008583 Bacterial Ig-like domain; Region: Big_5; pfam13205 512565008584 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 512565008585 CBD_II domain; Region: CBD_II; smart00637 512565008586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 512565008588 active site 512565008589 phosphorylation site [posttranslational modification] 512565008590 intermolecular recognition site; other site 512565008591 dimerization interface [polypeptide binding]; other site 512565008592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008593 DNA binding residues [nucleotide binding] 512565008594 dimerization interface [polypeptide binding]; other site 512565008595 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 512565008596 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 512565008597 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 512565008598 conserved cys residue [active] 512565008599 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565008600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565008601 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 512565008602 Isochorismatase family; Region: Isochorismatase; pfam00857 512565008603 catalytic triad [active] 512565008604 conserved cis-peptide bond; other site 512565008605 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 512565008606 Protein of unknown function, DUF624; Region: DUF624; pfam04854 512565008607 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 512565008608 EamA-like transporter family; Region: EamA; pfam00892 512565008609 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 512565008610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565008611 DNA-binding site [nucleotide binding]; DNA binding site 512565008612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565008613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565008614 homodimer interface [polypeptide binding]; other site 512565008615 catalytic residue [active] 512565008616 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565008617 DinB superfamily; Region: DinB_2; pfam12867 512565008618 Putative sensor; Region: Sensor; pfam13796 512565008619 Histidine kinase; Region: HisKA_3; pfam07730 512565008620 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565008621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565008622 active site 512565008623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008624 phosphorylation site [posttranslational modification] 512565008625 intermolecular recognition site; other site 512565008626 dimerization interface [polypeptide binding]; other site 512565008627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008628 DNA binding residues [nucleotide binding] 512565008629 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565008630 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565008631 Walker A/P-loop; other site 512565008632 ATP binding site [chemical binding]; other site 512565008633 Q-loop/lid; other site 512565008634 ABC transporter signature motif; other site 512565008635 Walker B; other site 512565008636 D-loop; other site 512565008637 H-loop/switch region; other site 512565008638 FtsX-like permease family; Region: FtsX; pfam02687 512565008639 Lipase (class 2); Region: Lipase_2; pfam01674 512565008640 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 512565008641 dimer interface [polypeptide binding]; other site 512565008642 catalytic triad [active] 512565008643 malate dehydrogenase; Provisional; Region: PRK05442 512565008644 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 512565008645 NAD(P) binding site [chemical binding]; other site 512565008646 dimer interface [polypeptide binding]; other site 512565008647 malate binding site [chemical binding]; other site 512565008648 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 512565008649 E3 interaction surface; other site 512565008650 lipoyl attachment site [posttranslational modification]; other site 512565008651 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 512565008652 e3 binding domain; Region: E3_binding; pfam02817 512565008653 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 512565008654 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 512565008655 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 512565008656 alpha subunit interface [polypeptide binding]; other site 512565008657 TPP binding site [chemical binding]; other site 512565008658 heterodimer interface [polypeptide binding]; other site 512565008659 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565008660 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 512565008661 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 512565008662 tetramer interface [polypeptide binding]; other site 512565008663 TPP-binding site [chemical binding]; other site 512565008664 heterodimer interface [polypeptide binding]; other site 512565008665 phosphorylation loop region [posttranslational modification] 512565008666 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565008667 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 512565008668 putative DNA binding site [nucleotide binding]; other site 512565008669 putative Zn2+ binding site [ion binding]; other site 512565008670 AsnC family; Region: AsnC_trans_reg; pfam01037 512565008671 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 512565008672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565008673 DNA-binding site [nucleotide binding]; DNA binding site 512565008674 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565008675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565008676 homodimer interface [polypeptide binding]; other site 512565008677 catalytic residue [active] 512565008678 transaminase; Validated; Region: PRK07324 512565008679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565008681 homodimer interface [polypeptide binding]; other site 512565008682 catalytic residue [active] 512565008683 Predicted transcriptional regulator [Transcription]; Region: COG2378 512565008684 WYL domain; Region: WYL; pfam13280 512565008685 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565008686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565008687 active site 512565008688 DoxX-like family; Region: DoxX_2; pfam13564 512565008689 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 512565008690 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 512565008691 putative dimer interface [polypeptide binding]; other site 512565008692 ligand binding site [chemical binding]; other site 512565008693 Zn binding site [ion binding]; other site 512565008694 Excalibur calcium-binding domain; Region: Excalibur; smart00894 512565008695 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 512565008696 Zn binding site [ion binding]; other site 512565008697 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 512565008698 GAF domain; Region: GAF; pfam01590 512565008699 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565008700 PAS domain; Region: PAS_9; pfam13426 512565008701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565008702 dimer interface [polypeptide binding]; other site 512565008703 phosphorylation site [posttranslational modification] 512565008704 PAS domain; Region: PAS_9; pfam13426 512565008705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565008706 dimer interface [polypeptide binding]; other site 512565008707 phosphorylation site [posttranslational modification] 512565008708 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565008709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565008710 ATP binding site [chemical binding]; other site 512565008711 Mg2+ binding site [ion binding]; other site 512565008712 G-X-G motif; other site 512565008713 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 512565008714 nudix motif; other site 512565008715 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 512565008716 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 512565008717 active site 512565008718 metal binding site [ion binding]; metal-binding site 512565008719 homotetramer interface [polypeptide binding]; other site 512565008720 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 512565008721 active site 512565008722 Family description; Region: VCBS; pfam13517 512565008723 Family description; Region: VCBS; pfam13517 512565008724 Family description; Region: VCBS; pfam13517 512565008725 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 512565008726 DNA protecting protein DprA; Region: dprA; TIGR00732 512565008727 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 512565008728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565008729 putative substrate translocation pore; other site 512565008730 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565008731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565008732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565008733 DNA binding residues [nucleotide binding] 512565008734 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565008735 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565008736 putative NAD(P) binding site [chemical binding]; other site 512565008737 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565008738 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565008739 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 512565008740 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 512565008741 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 512565008742 metal binding site [ion binding]; metal-binding site 512565008743 dimer interface [polypeptide binding]; other site 512565008744 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 512565008745 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 512565008746 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565008747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565008748 catalytic residue [active] 512565008749 PAS fold; Region: PAS_4; pfam08448 512565008750 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565008751 putative active site [active] 512565008752 heme pocket [chemical binding]; other site 512565008753 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565008754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565008755 metal binding site [ion binding]; metal-binding site 512565008756 active site 512565008757 I-site; other site 512565008758 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565008759 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 512565008760 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 512565008761 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565008762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565008763 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 512565008764 putative hydrophobic ligand binding site [chemical binding]; other site 512565008765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565008766 dimerization interface [polypeptide binding]; other site 512565008767 putative DNA binding site [nucleotide binding]; other site 512565008768 putative Zn2+ binding site [ion binding]; other site 512565008769 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565008770 anti sigma factor interaction site; other site 512565008771 regulatory phosphorylation site [posttranslational modification]; other site 512565008772 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 512565008773 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 512565008774 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565008775 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565008776 active site 512565008777 ATP binding site [chemical binding]; other site 512565008778 substrate binding site [chemical binding]; other site 512565008779 activation loop (A-loop); other site 512565008780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565008782 active site 512565008783 phosphorylation site [posttranslational modification] 512565008784 intermolecular recognition site; other site 512565008785 dimerization interface [polypeptide binding]; other site 512565008786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008787 DNA binding residues [nucleotide binding] 512565008788 dimerization interface [polypeptide binding]; other site 512565008789 Histidine kinase; Region: HisKA_3; pfam07730 512565008790 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565008791 CAAX protease self-immunity; Region: Abi; pfam02517 512565008792 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 512565008793 metal binding triad [ion binding]; metal-binding site 512565008794 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 512565008795 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565008796 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565008797 PQQ-like domain; Region: PQQ_2; pfam13360 512565008798 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512565008799 histidinol-phosphatase; Provisional; Region: PRK05588 512565008800 active site 512565008801 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 512565008802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565008803 dimerization interface [polypeptide binding]; other site 512565008804 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565008805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565008806 dimer interface [polypeptide binding]; other site 512565008807 putative CheW interface [polypeptide binding]; other site 512565008808 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 512565008809 apolar tunnel; other site 512565008810 heme binding site [chemical binding]; other site 512565008811 dimerization interface [polypeptide binding]; other site 512565008812 Short C-terminal domain; Region: SHOCT; pfam09851 512565008813 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565008814 Methyltransferase domain; Region: Methyltransf_24; pfam13578 512565008815 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512565008816 homotrimer interaction site [polypeptide binding]; other site 512565008817 putative active site [active] 512565008818 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 512565008819 Amidase; Region: Amidase; cl11426 512565008820 Transcriptional regulators [Transcription]; Region: GntR; COG1802 512565008821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565008822 DNA-binding site [nucleotide binding]; DNA binding site 512565008823 FCD domain; Region: FCD; pfam07729 512565008824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565008825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565008826 DNA binding site [nucleotide binding] 512565008827 domain linker motif; other site 512565008828 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565008829 ligand binding site [chemical binding]; other site 512565008830 dimerization interface [polypeptide binding]; other site 512565008831 Protein of unknown function DUF72; Region: DUF72; pfam01904 512565008832 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565008833 hypothetical protein; Reviewed; Region: PRK09588 512565008834 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 512565008835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565008836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008837 WHG domain; Region: WHG; pfam13305 512565008838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565008839 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565008840 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565008841 active site 512565008842 metal binding site [ion binding]; metal-binding site 512565008843 Homeodomain-like domain; Region: HTH_23; pfam13384 512565008844 Winged helix-turn helix; Region: HTH_29; pfam13551 512565008845 Homeodomain-like domain; Region: HTH_32; pfam13565 512565008846 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512565008847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 512565008848 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565008849 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565008850 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 512565008851 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565008852 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 512565008853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565008854 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 512565008855 AsnC family; Region: AsnC_trans_reg; pfam01037 512565008856 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565008857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565008858 putative substrate translocation pore; other site 512565008859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008860 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 512565008861 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565008862 maltose O-acetyltransferase; Provisional; Region: PRK10092 512565008863 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 512565008864 active site 512565008865 substrate binding site [chemical binding]; other site 512565008866 trimer interface [polypeptide binding]; other site 512565008867 CoA binding site [chemical binding]; other site 512565008868 short chain dehydrogenase; Validated; Region: PRK08324 512565008869 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 512565008870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565008871 NAD(P) binding site [chemical binding]; other site 512565008872 active site 512565008873 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 512565008874 N- and C-terminal domain interface [polypeptide binding]; other site 512565008875 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 512565008876 active site 512565008877 putative catalytic site [active] 512565008878 metal binding site [ion binding]; metal-binding site 512565008879 ATP binding site [chemical binding]; other site 512565008880 carbohydrate binding site [chemical binding]; other site 512565008881 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 512565008882 Cysteine-rich domain; Region: CCG; pfam02754 512565008883 Cysteine-rich domain; Region: CCG; pfam02754 512565008884 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 512565008885 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 512565008886 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 512565008887 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 512565008888 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 512565008889 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565008890 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 512565008891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565008892 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565008893 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 512565008894 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 512565008895 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565008896 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565008897 O-methyltransferase; Region: Methyltransf_2; pfam00891 512565008898 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 512565008899 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565008900 MarR family; Region: MarR; pfam01047 512565008901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565008902 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565008903 active site 512565008904 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 512565008905 homotetrameric interface [polypeptide binding]; other site 512565008906 putative active site [active] 512565008907 metal binding site [ion binding]; metal-binding site 512565008908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565008909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565008910 active site 512565008911 phosphorylation site [posttranslational modification] 512565008912 intermolecular recognition site; other site 512565008913 dimerization interface [polypeptide binding]; other site 512565008914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565008915 DNA binding residues [nucleotide binding] 512565008916 dimerization interface [polypeptide binding]; other site 512565008917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565008918 Histidine kinase; Region: HisKA_3; pfam07730 512565008919 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565008920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565008921 Walker A/P-loop; other site 512565008922 ATP binding site [chemical binding]; other site 512565008923 Q-loop/lid; other site 512565008924 ABC transporter signature motif; other site 512565008925 Walker B; other site 512565008926 D-loop; other site 512565008927 H-loop/switch region; other site 512565008928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565008929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008930 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 512565008931 putative acetyltransferase; Provisional; Region: PRK03624 512565008932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565008933 Coenzyme A binding pocket [chemical binding]; other site 512565008934 Protein of unknown function (DUF419); Region: DUF419; cl15265 512565008935 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 512565008936 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565008937 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 512565008938 EamA-like transporter family; Region: EamA; pfam00892 512565008939 EamA-like transporter family; Region: EamA; pfam00892 512565008940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565008941 MarR family; Region: MarR_2; cl17246 512565008942 AAA domain; Region: AAA_22; pfam13401 512565008943 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565008944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565008945 Tetratricopeptide repeat; Region: TPR_10; pfam13374 512565008946 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565008947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565008948 binding surface 512565008949 TPR motif; other site 512565008950 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565008951 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 512565008952 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 512565008953 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 512565008954 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 512565008955 homodimer interaction site [polypeptide binding]; other site 512565008956 cofactor binding site; other site 512565008957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565008958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565008959 hypothetical protein; Provisional; Region: PRK07236 512565008960 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 512565008961 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565008962 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 512565008963 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565008964 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 512565008965 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565008966 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 512565008967 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 512565008968 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 512565008969 Trehalase; Region: Trehalase; cl17346 512565008970 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565008971 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565008972 DNA binding site [nucleotide binding] 512565008973 domain linker motif; other site 512565008974 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565008975 ligand binding site [chemical binding]; other site 512565008976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565008977 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565008978 active site 512565008979 metal binding site [ion binding]; metal-binding site 512565008980 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565008981 NIPSNAP; Region: NIPSNAP; pfam07978 512565008982 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 512565008983 [4Fe-4S] binding site [ion binding]; other site 512565008984 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 512565008985 molybdopterin cofactor binding site; other site 512565008986 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 512565008987 molybdopterin cofactor binding site; other site 512565008988 Protein of unknown function (DUF998); Region: DUF998; pfam06197 512565008989 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565008990 G5 box; other site 512565008991 endoglucanase; Region: PLN02420 512565008992 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 512565008993 Cellulose binding domain; Region: CBM_3; cl03026 512565008994 Cellulose binding domain; Region: CBM_2; pfam00553 512565008995 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 512565008996 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 512565008997 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565008998 catalytic residue [active] 512565008999 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565009000 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 512565009001 metal binding site [ion binding]; metal-binding site 512565009002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565009003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565009004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565009005 dimerization interface [polypeptide binding]; other site 512565009006 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565009007 AAA ATPase domain; Region: AAA_16; pfam13191 512565009008 Predicted ATPase [General function prediction only]; Region: COG3903 512565009009 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565009010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009011 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 512565009012 Walker A/P-loop; other site 512565009013 ATP binding site [chemical binding]; other site 512565009014 Q-loop/lid; other site 512565009015 ABC transporter signature motif; other site 512565009016 Walker B; other site 512565009017 D-loop; other site 512565009018 H-loop/switch region; other site 512565009019 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 512565009020 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 512565009021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565009022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009023 Secretory lipase; Region: LIP; pfam03583 512565009024 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 512565009025 SnoaL-like domain; Region: SnoaL_3; pfam13474 512565009026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 512565009027 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565009028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565009029 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565009030 Coenzyme A binding pocket [chemical binding]; other site 512565009031 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565009032 DNA binding site [nucleotide binding] 512565009033 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512565009034 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 512565009035 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 512565009036 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565009037 anti sigma factor interaction site; other site 512565009038 regulatory phosphorylation site [posttranslational modification]; other site 512565009039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 512565009040 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565009041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565009042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565009043 dimer interface [polypeptide binding]; other site 512565009044 phosphorylation site [posttranslational modification] 512565009045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009046 ATP binding site [chemical binding]; other site 512565009047 Mg2+ binding site [ion binding]; other site 512565009048 G-X-G motif; other site 512565009049 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 512565009050 classical (c) SDRs; Region: SDR_c; cd05233 512565009051 NAD(P) binding site [chemical binding]; other site 512565009052 active site 512565009053 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565009054 MarR family; Region: MarR; pfam01047 512565009055 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 512565009056 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 512565009057 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565009058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565009059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009060 Walker A/P-loop; other site 512565009061 ATP binding site [chemical binding]; other site 512565009062 Q-loop/lid; other site 512565009063 ABC transporter signature motif; other site 512565009064 Walker B; other site 512565009065 D-loop; other site 512565009066 H-loop/switch region; other site 512565009067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565009068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565009069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009070 Walker A/P-loop; other site 512565009071 ATP binding site [chemical binding]; other site 512565009072 Q-loop/lid; other site 512565009073 ABC transporter signature motif; other site 512565009074 Walker B; other site 512565009075 D-loop; other site 512565009076 H-loop/switch region; other site 512565009077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565009078 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565009079 Walker A/P-loop; other site 512565009080 ATP binding site [chemical binding]; other site 512565009081 Q-loop/lid; other site 512565009082 ABC transporter signature motif; other site 512565009083 Walker B; other site 512565009084 D-loop; other site 512565009085 H-loop/switch region; other site 512565009086 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565009087 ABC-ATPase subunit interface; other site 512565009088 dimer interface [polypeptide binding]; other site 512565009089 putative PBP binding regions; other site 512565009090 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565009091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 512565009092 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565009093 ABC-ATPase subunit interface; other site 512565009094 dimer interface [polypeptide binding]; other site 512565009095 putative PBP binding regions; other site 512565009096 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 512565009097 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 512565009098 siderophore binding site; other site 512565009099 active site 512565009100 metal binding site [ion binding]; metal-binding site 512565009101 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565009102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565009103 Coenzyme A binding pocket [chemical binding]; other site 512565009104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565009105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565009106 dimer interface [polypeptide binding]; other site 512565009107 phosphorylation site [posttranslational modification] 512565009108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009109 ATP binding site [chemical binding]; other site 512565009110 Mg2+ binding site [ion binding]; other site 512565009111 G-X-G motif; other site 512565009112 Response regulator receiver domain; Region: Response_reg; pfam00072 512565009113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009114 active site 512565009115 phosphorylation site [posttranslational modification] 512565009116 intermolecular recognition site; other site 512565009117 dimerization interface [polypeptide binding]; other site 512565009118 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 512565009119 putative hydrophobic ligand binding site [chemical binding]; other site 512565009120 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 512565009121 A new structural DNA glycosylase; Region: AlkD_like; cd06561 512565009122 active site 512565009123 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 512565009124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565009125 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565009126 Coenzyme A binding pocket [chemical binding]; other site 512565009127 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565009128 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 512565009129 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565009130 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565009131 active site 512565009132 catalytic tetrad [active] 512565009133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565009134 active site 512565009135 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565009136 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565009137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565009138 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 512565009139 NAD(P) binding site [chemical binding]; other site 512565009140 active site 512565009141 acyl-CoA synthetase; Validated; Region: PRK07788 512565009142 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565009143 acyl-activating enzyme (AAE) consensus motif; other site 512565009144 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565009145 AMP binding site [chemical binding]; other site 512565009146 active site 512565009147 acyl-activating enzyme (AAE) consensus motif; other site 512565009148 CoA binding site [chemical binding]; other site 512565009149 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565009150 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565009152 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565009153 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565009154 NodB motif; other site 512565009155 active site 512565009156 catalytic site [active] 512565009157 metal binding site [ion binding]; metal-binding site 512565009158 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512565009159 oxyanion hole [active] 512565009160 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 512565009161 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 512565009162 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 512565009163 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 512565009164 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565009165 ChaB; Region: ChaB; pfam06150 512565009166 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 512565009167 Phosphotransferase enzyme family; Region: APH; pfam01636 512565009168 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565009169 active site 512565009170 ATP binding site [chemical binding]; other site 512565009171 substrate binding site [chemical binding]; other site 512565009172 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565009173 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565009174 dimerization interface [polypeptide binding]; other site 512565009175 putative DNA binding site [nucleotide binding]; other site 512565009176 putative Zn2+ binding site [ion binding]; other site 512565009177 PRC-barrel domain; Region: PRC; pfam05239 512565009178 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 512565009179 putative hydrophobic ligand binding site [chemical binding]; other site 512565009180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565009181 putative DNA binding site [nucleotide binding]; other site 512565009182 putative Zn2+ binding site [ion binding]; other site 512565009183 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 512565009184 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 512565009185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565009186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009187 active site 512565009188 phosphorylation site [posttranslational modification] 512565009189 intermolecular recognition site; other site 512565009190 dimerization interface [polypeptide binding]; other site 512565009191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565009192 DNA binding residues [nucleotide binding] 512565009193 dimerization interface [polypeptide binding]; other site 512565009194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565009195 Histidine kinase; Region: HisKA_3; pfam07730 512565009196 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565009197 ATP binding site [chemical binding]; other site 512565009198 Mg2+ binding site [ion binding]; other site 512565009199 G-X-G motif; other site 512565009200 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 512565009201 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 512565009202 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 512565009203 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 512565009204 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 512565009205 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565009206 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565009207 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565009208 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 512565009209 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565009210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565009211 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565009212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565009213 Transcriptional regulator [Transcription]; Region: LytR; COG1316 512565009214 aminotransferase; Validated; Region: PRK07337 512565009215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565009216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565009217 homodimer interface [polypeptide binding]; other site 512565009218 catalytic residue [active] 512565009219 Helix-turn-helix domain; Region: HTH_17; cl17695 512565009220 Cupin domain; Region: Cupin_2; pfam07883 512565009221 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 512565009222 phosphoenolpyruvate synthase; Validated; Region: PRK06241 512565009223 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 512565009224 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 512565009225 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565009226 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 512565009227 putative NAD(P) binding site [chemical binding]; other site 512565009228 catalytic Zn binding site [ion binding]; other site 512565009229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565009230 HAMP domain; Region: HAMP; pfam00672 512565009231 dimerization interface [polypeptide binding]; other site 512565009232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565009233 dimer interface [polypeptide binding]; other site 512565009234 phosphorylation site [posttranslational modification] 512565009235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009236 ATP binding site [chemical binding]; other site 512565009237 Mg2+ binding site [ion binding]; other site 512565009238 G-X-G motif; other site 512565009239 Response regulator receiver domain; Region: Response_reg; pfam00072 512565009240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009241 active site 512565009242 phosphorylation site [posttranslational modification] 512565009243 intermolecular recognition site; other site 512565009244 dimerization interface [polypeptide binding]; other site 512565009245 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 512565009246 putative binding surface; other site 512565009247 active site 512565009248 Response regulator receiver domain; Region: Response_reg; pfam00072 512565009249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009250 active site 512565009251 phosphorylation site [posttranslational modification] 512565009252 intermolecular recognition site; other site 512565009253 dimerization interface [polypeptide binding]; other site 512565009254 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 512565009255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565009256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565009257 dimer interface [polypeptide binding]; other site 512565009258 phosphorylation site [posttranslational modification] 512565009259 HlyD family secretion protein; Region: HlyD_3; pfam13437 512565009260 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 512565009261 HlyD family secretion protein; Region: HlyD_3; pfam13437 512565009262 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565009263 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565009264 Walker A/P-loop; other site 512565009265 ATP binding site [chemical binding]; other site 512565009266 Q-loop/lid; other site 512565009267 ABC transporter signature motif; other site 512565009268 Walker B; other site 512565009269 D-loop; other site 512565009270 H-loop/switch region; other site 512565009271 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565009272 FtsX-like permease family; Region: FtsX; pfam02687 512565009273 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565009274 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 512565009275 metal binding site [ion binding]; metal-binding site 512565009276 Uncharacterized conserved protein [Function unknown]; Region: COG3375 512565009277 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512565009278 putative active site [active] 512565009279 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 512565009280 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 512565009281 metal binding site [ion binding]; metal-binding site 512565009282 substrate binding pocket [chemical binding]; other site 512565009283 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565009284 active site 512565009285 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 512565009286 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 512565009287 Predicted transcription factor, homolog of eukaryotic MBF1 [Transcription]; Region: COG1813 512565009288 Homeodomain-like domain; Region: HTH_23; cl17451 512565009289 Winged helix-turn helix; Region: HTH_29; pfam13551 512565009290 Integrase core domain; Region: rve; pfam00665 512565009291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 512565009292 Integrase core domain; Region: rve_3; pfam13683 512565009293 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 512565009294 nudix motif; other site 512565009295 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565009296 catalytic core [active] 512565009297 ATP binding site [chemical binding]; other site 512565009298 Phosphotransferase enzyme family; Region: APH; pfam01636 512565009299 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565009300 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565009301 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565009302 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565009303 DNA binding residues [nucleotide binding] 512565009304 aminotransferase; Validated; Region: PRK07046 512565009305 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565009306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565009307 catalytic residue [active] 512565009308 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 512565009309 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 512565009310 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 512565009311 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 512565009312 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 512565009313 amino acid transporter; Region: 2A0306; TIGR00909 512565009314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565009315 Ligand Binding Site [chemical binding]; other site 512565009316 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 512565009317 active site 512565009318 putative catalytic site [active] 512565009319 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 512565009320 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 512565009321 Peptidase family M28; Region: Peptidase_M28; pfam04389 512565009322 active site 512565009323 metal binding site [ion binding]; metal-binding site 512565009324 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565009325 TAP-like protein; Region: Abhydrolase_4; pfam08386 512565009326 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565009327 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565009328 Walker A/P-loop; other site 512565009329 ATP binding site [chemical binding]; other site 512565009330 Q-loop/lid; other site 512565009331 ABC transporter signature motif; other site 512565009332 Walker B; other site 512565009333 D-loop; other site 512565009334 H-loop/switch region; other site 512565009335 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565009336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009337 putative PBP binding loops; other site 512565009338 ABC-ATPase subunit interface; other site 512565009339 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565009340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009341 dimer interface [polypeptide binding]; other site 512565009342 conserved gate region; other site 512565009343 putative PBP binding loops; other site 512565009344 ABC-ATPase subunit interface; other site 512565009345 NMT1-like family; Region: NMT1_2; pfam13379 512565009346 NMT1/THI5 like; Region: NMT1; pfam09084 512565009347 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 512565009348 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565009349 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565009350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565009351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565009352 metal binding site [ion binding]; metal-binding site 512565009353 active site 512565009354 I-site; other site 512565009355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565009356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565009357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009358 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565009359 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009360 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 512565009361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565009362 Coenzyme A binding pocket [chemical binding]; other site 512565009363 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 512565009364 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 512565009365 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565009366 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 512565009367 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 512565009368 Uncharacterized conserved protein [Function unknown]; Region: COG1479 512565009369 Protein of unknown function DUF262; Region: DUF262; pfam03235 512565009370 Protein of unknown function DUF262; Region: DUF262; pfam03235 512565009371 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565009372 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565009373 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 512565009374 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565009375 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565009376 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565009377 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565009378 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 512565009379 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 512565009380 active site 512565009381 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 512565009382 active site 512565009383 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 512565009384 tetramer interface [polypeptide binding]; other site 512565009385 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 512565009386 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565009387 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 512565009388 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565009389 Cellulose binding domain; Region: CBM_2; pfam00553 512565009390 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 512565009391 Protease prsW family; Region: PrsW-protease; pfam13367 512565009392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565009393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565009394 putative substrate translocation pore; other site 512565009395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565009396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565009397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565009398 dimerization interface [polypeptide binding]; other site 512565009399 hypothetical protein; Provisional; Region: PRK06847 512565009400 hypothetical protein; Provisional; Region: PRK07236 512565009401 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 512565009402 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565009403 active site 512565009404 metal binding site [ion binding]; metal-binding site 512565009405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565009406 active site 512565009407 metal binding site [ion binding]; metal-binding site 512565009408 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 512565009409 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 512565009410 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 512565009411 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565009412 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 512565009413 Putative cyclase; Region: Cyclase; pfam04199 512565009414 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 512565009415 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 512565009416 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 512565009417 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565009418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565009419 S-adenosylmethionine binding site [chemical binding]; other site 512565009420 PAS domain S-box; Region: sensory_box; TIGR00229 512565009421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565009422 putative active site [active] 512565009423 heme pocket [chemical binding]; other site 512565009424 PAS domain S-box; Region: sensory_box; TIGR00229 512565009425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565009426 putative active site [active] 512565009427 heme pocket [chemical binding]; other site 512565009428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009429 ATP binding site [chemical binding]; other site 512565009430 Mg2+ binding site [ion binding]; other site 512565009431 G-X-G motif; other site 512565009432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009433 active site 512565009434 phosphorylation site [posttranslational modification] 512565009435 intermolecular recognition site; other site 512565009436 dimerization interface [polypeptide binding]; other site 512565009437 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 512565009438 Domain interface; other site 512565009439 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 512565009440 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 512565009441 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565009442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565009443 S-adenosylmethionine binding site [chemical binding]; other site 512565009444 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 512565009445 SpoOM protein; Region: Spo0M; pfam07070 512565009446 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 512565009447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565009448 S-adenosylmethionine binding site [chemical binding]; other site 512565009449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 512565009450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009451 Walker A/P-loop; other site 512565009452 ATP binding site [chemical binding]; other site 512565009453 Q-loop/lid; other site 512565009454 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512565009455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009456 Walker A/P-loop; other site 512565009457 ATP binding site [chemical binding]; other site 512565009458 Q-loop/lid; other site 512565009459 ABC transporter; Region: ABC_tran; pfam00005 512565009460 ABC transporter signature motif; other site 512565009461 Walker B; other site 512565009462 D-loop; other site 512565009463 H-loop/switch region; other site 512565009464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009465 active site 512565009466 phosphorylation site [posttranslational modification] 512565009467 intermolecular recognition site; other site 512565009468 dimerization interface [polypeptide binding]; other site 512565009469 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 512565009470 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 512565009471 FAD binding pocket [chemical binding]; other site 512565009472 FAD binding motif [chemical binding]; other site 512565009473 phosphate binding motif [ion binding]; other site 512565009474 NAD binding pocket [chemical binding]; other site 512565009475 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565009476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565009477 dimerization interface [polypeptide binding]; other site 512565009478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565009479 dimer interface [polypeptide binding]; other site 512565009480 putative CheW interface [polypeptide binding]; other site 512565009481 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565009482 Ligand Binding Site [chemical binding]; other site 512565009483 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 512565009484 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 512565009485 potential catalytic triad [active] 512565009486 conserved cys residue [active] 512565009487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565009488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565009489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565009490 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565009491 MarR family; Region: MarR; pfam01047 512565009492 glutamine synthetase; Region: PLN02284 512565009493 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 512565009494 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 512565009495 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 512565009496 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565009497 anti sigma factor interaction site; other site 512565009498 regulatory phosphorylation site [posttranslational modification]; other site 512565009499 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565009500 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565009501 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565009502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565009503 non-specific DNA binding site [nucleotide binding]; other site 512565009504 salt bridge; other site 512565009505 sequence-specific DNA binding site [nucleotide binding]; other site 512565009506 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565009507 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565009508 Walker A motif; other site 512565009509 ATP binding site [chemical binding]; other site 512565009510 Walker B motif; other site 512565009511 PAS fold; Region: PAS_3; pfam08447 512565009512 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565009513 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565009514 active site 512565009515 ATP binding site [chemical binding]; other site 512565009516 substrate binding site [chemical binding]; other site 512565009517 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 512565009518 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 512565009519 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565009520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009521 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565009522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565009523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565009524 active site 512565009525 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 512565009526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565009527 NAD(P) binding site [chemical binding]; other site 512565009528 active site 512565009529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565009530 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565009531 active site 512565009532 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565009533 cleavage site 512565009534 active site 512565009535 substrate binding sites [chemical binding]; other site 512565009536 glycogen branching enzyme; Provisional; Region: PRK14705 512565009537 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 512565009538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565009539 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565009540 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 512565009541 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565009542 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 512565009543 ligand binding site [chemical binding]; other site 512565009544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565009545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565009546 DNA binding site [nucleotide binding] 512565009547 domain linker motif; other site 512565009548 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565009549 dimerization interface [polypeptide binding]; other site 512565009550 ligand binding site [chemical binding]; other site 512565009551 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565009552 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565009553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009554 dimer interface [polypeptide binding]; other site 512565009555 conserved gate region; other site 512565009556 putative PBP binding loops; other site 512565009557 ABC-ATPase subunit interface; other site 512565009558 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565009559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009560 dimer interface [polypeptide binding]; other site 512565009561 conserved gate region; other site 512565009562 putative PBP binding loops; other site 512565009563 ABC-ATPase subunit interface; other site 512565009564 putative alpha-glucosidase; Provisional; Region: PRK10658 512565009565 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 512565009566 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 512565009567 active site 512565009568 homotrimer interface [polypeptide binding]; other site 512565009569 catalytic site [active] 512565009570 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 512565009571 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565009572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565009573 substrate binding site [chemical binding]; other site 512565009574 oxyanion hole (OAH) forming residues; other site 512565009575 trimer interface [polypeptide binding]; other site 512565009576 putative phosphoketolase; Provisional; Region: PRK05261 512565009577 XFP N-terminal domain; Region: XFP_N; pfam09364 512565009578 XFP C-terminal domain; Region: XFP_C; pfam09363 512565009579 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 512565009580 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 512565009581 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 512565009582 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512565009583 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512565009584 Walker A/P-loop; other site 512565009585 ATP binding site [chemical binding]; other site 512565009586 Q-loop/lid; other site 512565009587 ABC transporter signature motif; other site 512565009588 Walker B; other site 512565009589 D-loop; other site 512565009590 H-loop/switch region; other site 512565009591 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 512565009592 PDGLE domain; Region: PDGLE; pfam13190 512565009593 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 512565009594 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 512565009595 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 512565009596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565009597 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565009598 Histidine kinase; Region: HisKA_3; pfam07730 512565009599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565009600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009601 ATP binding site [chemical binding]; other site 512565009602 Mg2+ binding site [ion binding]; other site 512565009603 G-X-G motif; other site 512565009604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565009605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009606 active site 512565009607 phosphorylation site [posttranslational modification] 512565009608 intermolecular recognition site; other site 512565009609 dimerization interface [polypeptide binding]; other site 512565009610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565009611 DNA binding residues [nucleotide binding] 512565009612 dimerization interface [polypeptide binding]; other site 512565009613 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565009614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565009615 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 512565009616 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565009617 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565009618 dimer interface [polypeptide binding]; other site 512565009619 putative CheW interface [polypeptide binding]; other site 512565009620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565009621 GAF domain; Region: GAF; pfam01590 512565009622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565009623 dimer interface [polypeptide binding]; other site 512565009624 phosphorylation site [posttranslational modification] 512565009625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009626 ATP binding site [chemical binding]; other site 512565009627 Mg2+ binding site [ion binding]; other site 512565009628 G-X-G motif; other site 512565009629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009630 active site 512565009631 phosphorylation site [posttranslational modification] 512565009632 intermolecular recognition site; other site 512565009633 dimerization interface [polypeptide binding]; other site 512565009634 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 512565009635 putative binding surface; other site 512565009636 active site 512565009637 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 512565009638 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565009639 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565009640 TM-ABC transporter signature motif; other site 512565009641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565009642 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565009643 TM-ABC transporter signature motif; other site 512565009644 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 512565009645 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565009646 Walker A/P-loop; other site 512565009647 ATP binding site [chemical binding]; other site 512565009648 Q-loop/lid; other site 512565009649 ABC transporter signature motif; other site 512565009650 Walker B; other site 512565009651 D-loop; other site 512565009652 H-loop/switch region; other site 512565009653 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512565009654 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565009655 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 512565009656 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 512565009657 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 512565009658 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 512565009659 active site 512565009660 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565009661 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565009662 active site 512565009663 ATP binding site [chemical binding]; other site 512565009664 substrate binding site [chemical binding]; other site 512565009665 activation loop (A-loop); other site 512565009666 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565009667 putative active site [active] 512565009668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565009669 DNA-binding site [nucleotide binding]; DNA binding site 512565009670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565009671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565009672 homodimer interface [polypeptide binding]; other site 512565009673 catalytic residue [active] 512565009674 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 512565009675 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 512565009676 tetrameric interface [polypeptide binding]; other site 512565009677 NAD binding site [chemical binding]; other site 512565009678 catalytic residues [active] 512565009679 hypothetical protein; Provisional; Region: PRK06062 512565009680 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565009681 inhibitor-cofactor binding pocket; inhibition site 512565009682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565009683 catalytic residue [active] 512565009684 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 512565009685 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 512565009686 tetrameric interface [polypeptide binding]; other site 512565009687 NAD binding site [chemical binding]; other site 512565009688 catalytic residues [active] 512565009689 substrate binding site [chemical binding]; other site 512565009690 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512565009691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009692 Walker A/P-loop; other site 512565009693 ATP binding site [chemical binding]; other site 512565009694 Q-loop/lid; other site 512565009695 ABC transporter signature motif; other site 512565009696 Walker B; other site 512565009697 D-loop; other site 512565009698 H-loop/switch region; other site 512565009699 TOBE domain; Region: TOBE_2; pfam08402 512565009700 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 512565009701 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 512565009702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009703 dimer interface [polypeptide binding]; other site 512565009704 conserved gate region; other site 512565009705 putative PBP binding loops; other site 512565009706 ABC-ATPase subunit interface; other site 512565009707 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512565009708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009709 dimer interface [polypeptide binding]; other site 512565009710 conserved gate region; other site 512565009711 putative PBP binding loops; other site 512565009712 ABC-ATPase subunit interface; other site 512565009713 hypothetical protein; Provisional; Region: PRK06541 512565009714 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565009715 inhibitor-cofactor binding pocket; inhibition site 512565009716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565009717 catalytic residue [active] 512565009718 Response regulator receiver domain; Region: Response_reg; pfam00072 512565009719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565009720 active site 512565009721 phosphorylation site [posttranslational modification] 512565009722 intermolecular recognition site; other site 512565009723 dimerization interface [polypeptide binding]; other site 512565009724 GAF domain; Region: GAF; pfam01590 512565009725 GAF domain; Region: GAF_2; pfam13185 512565009726 PAS domain; Region: PAS; smart00091 512565009727 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565009728 GAF domain; Region: GAF; pfam01590 512565009729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565009730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565009731 dimer interface [polypeptide binding]; other site 512565009732 phosphorylation site [posttranslational modification] 512565009733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565009734 ATP binding site [chemical binding]; other site 512565009735 Mg2+ binding site [ion binding]; other site 512565009736 G-X-G motif; other site 512565009737 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 512565009738 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 512565009739 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565009740 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 512565009741 AsnC family; Region: AsnC_trans_reg; pfam01037 512565009742 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 512565009743 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565009744 inhibitor-cofactor binding pocket; inhibition site 512565009745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565009746 catalytic residue [active] 512565009747 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 512565009748 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 512565009749 tetrameric interface [polypeptide binding]; other site 512565009750 NAD binding site [chemical binding]; other site 512565009751 catalytic residues [active] 512565009752 substrate binding site [chemical binding]; other site 512565009753 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565009754 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565009755 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565009756 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565009757 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565009758 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 512565009759 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565009760 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565009761 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565009762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009763 dimer interface [polypeptide binding]; other site 512565009764 conserved gate region; other site 512565009765 putative PBP binding loops; other site 512565009766 ABC-ATPase subunit interface; other site 512565009767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565009768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009769 dimer interface [polypeptide binding]; other site 512565009770 conserved gate region; other site 512565009771 putative PBP binding loops; other site 512565009772 ABC-ATPase subunit interface; other site 512565009773 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565009774 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565009775 DNA binding site [nucleotide binding] 512565009776 domain linker motif; other site 512565009777 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 512565009778 putative dimerization interface [polypeptide binding]; other site 512565009779 putative ligand binding site [chemical binding]; other site 512565009780 Protein of unknown function (DUF402); Region: DUF402; cl00979 512565009781 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565009782 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 512565009783 exopolyphosphatase; Region: exo_poly_only; TIGR03706 512565009784 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 512565009785 Uncharacterized conserved protein [Function unknown]; Region: COG1262 512565009786 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 512565009787 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 512565009788 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 512565009789 putative dimer interface [polypeptide binding]; other site 512565009790 hydroperoxidase II; Provisional; Region: katE; PRK11249 512565009791 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 512565009792 heme binding pocket [chemical binding]; other site 512565009793 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 512565009794 domain interactions; other site 512565009795 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 512565009796 putative active site pocket [active] 512565009797 cleavage site 512565009798 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 512565009799 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565009800 Domain of unknown function (DUF427); Region: DUF427; cl00998 512565009801 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 512565009802 putative deacylase active site [active] 512565009803 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 512565009804 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 512565009805 NADP binding site [chemical binding]; other site 512565009806 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565009807 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565009808 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 512565009809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565009810 dimerization interface [polypeptide binding]; other site 512565009811 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565009812 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565009813 dimer interface [polypeptide binding]; other site 512565009814 putative CheW interface [polypeptide binding]; other site 512565009815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565009816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565009817 metal binding site [ion binding]; metal-binding site 512565009818 active site 512565009819 I-site; other site 512565009820 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 512565009821 CoA-transferase family III; Region: CoA_transf_3; pfam02515 512565009822 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565009823 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565009824 active site 512565009825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565009826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009827 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 512565009828 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565009829 acyl-activating enzyme (AAE) consensus motif; other site 512565009830 AMP binding site [chemical binding]; other site 512565009831 active site 512565009832 CoA binding site [chemical binding]; other site 512565009833 Sulfatase; Region: Sulfatase; cl17466 512565009834 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565009835 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 512565009836 active site 512565009837 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 512565009838 non-prolyl cis peptide bond; other site 512565009839 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565009840 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 512565009841 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565009842 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 512565009843 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565009844 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565009845 putative NAD(P) binding site [chemical binding]; other site 512565009846 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565009847 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565009848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565009849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565009850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512565009851 dimerization interface [polypeptide binding]; other site 512565009852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565009853 Coenzyme A binding pocket [chemical binding]; other site 512565009854 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512565009855 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565009856 substrate binding pocket [chemical binding]; other site 512565009857 membrane-bound complex binding site; other site 512565009858 hinge residues; other site 512565009859 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512565009860 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512565009861 Walker A/P-loop; other site 512565009862 ATP binding site [chemical binding]; other site 512565009863 Q-loop/lid; other site 512565009864 ABC transporter signature motif; other site 512565009865 Walker B; other site 512565009866 D-loop; other site 512565009867 H-loop/switch region; other site 512565009868 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565009869 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 512565009870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565009871 dimer interface [polypeptide binding]; other site 512565009872 conserved gate region; other site 512565009873 putative PBP binding loops; other site 512565009874 ABC-ATPase subunit interface; other site 512565009875 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565009876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512565009877 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 512565009878 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512565009879 active site 512565009880 catalytic site [active] 512565009881 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 512565009882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565009883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565009884 DNA binding site [nucleotide binding] 512565009885 domain linker motif; other site 512565009886 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565009887 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 512565009888 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 512565009889 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 512565009890 active site 512565009891 dimer interface [polypeptide binding]; other site 512565009892 non-prolyl cis peptide bond; other site 512565009893 insertion regions; other site 512565009894 MMPL family; Region: MMPL; pfam03176 512565009895 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565009896 MarR family; Region: MarR; pfam01047 512565009897 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565009898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565009899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565009900 Walker A/P-loop; other site 512565009901 ATP binding site [chemical binding]; other site 512565009902 Q-loop/lid; other site 512565009903 ABC transporter signature motif; other site 512565009904 Walker B; other site 512565009905 D-loop; other site 512565009906 H-loop/switch region; other site 512565009907 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565009908 MarR family; Region: MarR; pfam01047 512565009909 MarR family; Region: MarR_2; cl17246 512565009910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565009911 TPR motif; other site 512565009912 TPR repeat; Region: TPR_11; pfam13414 512565009913 binding surface 512565009914 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 512565009915 active site 512565009916 catalytic residues [active] 512565009917 FMN binding site [chemical binding]; other site 512565009918 Nitroreductase family; Region: Nitroreductase; pfam00881 512565009919 dimer interface [polypeptide binding]; other site 512565009920 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565009921 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 512565009922 Citrate synthase; Region: Citrate_synt; pfam00285 512565009923 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 512565009924 dimer interface [polypeptide binding]; other site 512565009925 active site 512565009926 oxalacetate/citrate binding site [chemical binding]; other site 512565009927 citrylCoA binding site [chemical binding]; other site 512565009928 coenzyme A binding site [chemical binding]; other site 512565009929 catalytic triad [active] 512565009930 citrate synthase 2; Provisional; Region: PRK12350 512565009931 Citrate synthase; Region: Citrate_synt; pfam00285 512565009932 oxalacetate binding site [chemical binding]; other site 512565009933 citrylCoA binding site [chemical binding]; other site 512565009934 coenzyme A binding site [chemical binding]; other site 512565009935 catalytic triad [active] 512565009936 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565009937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565009938 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 512565009939 NAD(P) binding site [chemical binding]; other site 512565009940 active site 512565009941 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565009942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565009943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565009944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565009945 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 512565009946 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 512565009947 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 512565009948 active site 512565009949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 512565009950 DNA binding site [nucleotide binding] 512565009951 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 512565009952 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 512565009953 putative active site [active] 512565009954 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 512565009955 active site 512565009956 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 512565009957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565009958 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 512565009959 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 512565009960 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 512565009961 iron-sulfur cluster [ion binding]; other site 512565009962 [2Fe-2S] cluster binding site [ion binding]; other site 512565009963 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 512565009964 Acyltransferase family; Region: Acyl_transf_3; pfam01757 512565009965 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 512565009966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565009967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565009968 DNA binding site [nucleotide binding] 512565009969 domain linker motif; other site 512565009970 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 512565009971 putative dimerization interface [polypeptide binding]; other site 512565009972 putative ligand binding site [chemical binding]; other site 512565009973 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 512565009974 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 512565009975 putative metal binding site [ion binding]; other site 512565009976 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 512565009977 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565009978 metal binding site [ion binding]; metal-binding site 512565009979 active site 512565009980 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 512565009981 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565009982 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565009983 Walker A/P-loop; other site 512565009984 ATP binding site [chemical binding]; other site 512565009985 Q-loop/lid; other site 512565009986 ABC transporter signature motif; other site 512565009987 Walker B; other site 512565009988 D-loop; other site 512565009989 H-loop/switch region; other site 512565009990 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565009991 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 512565009992 heme-binding site [chemical binding]; other site 512565009993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565009994 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 512565009995 NAD(P) binding site [chemical binding]; other site 512565009996 active site 512565009997 short chain dehydrogenase; Provisional; Region: PRK06179 512565009998 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 512565009999 NADP binding site [chemical binding]; other site 512565010000 active site 512565010001 steroid binding site; other site 512565010002 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 512565010003 Esterase/lipase [General function prediction only]; Region: COG1647 512565010004 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 512565010005 classical (c) SDRs; Region: SDR_c; cd05233 512565010006 NAD(P) binding site [chemical binding]; other site 512565010007 active site 512565010008 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 512565010009 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565010010 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565010011 catalytic residue [active] 512565010012 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565010013 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565010014 DNA binding site [nucleotide binding] 512565010015 domain linker motif; other site 512565010016 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565010017 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565010018 sugar binding site [chemical binding]; other site 512565010019 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 512565010020 Domain of unknown function (DUF305); Region: DUF305; cl17794 512565010021 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565010022 sugar binding site [chemical binding]; other site 512565010023 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 512565010024 active site 512565010025 catalytic residues [active] 512565010026 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 512565010027 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565010028 sugar binding site [chemical binding]; other site 512565010029 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565010030 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565010031 sugar binding site [chemical binding]; other site 512565010032 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 512565010033 active site 512565010034 catalytic residues [active] 512565010035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565010036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565010037 dimer interface [polypeptide binding]; other site 512565010038 phosphorylation site [posttranslational modification] 512565010039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565010040 ATP binding site [chemical binding]; other site 512565010041 Mg2+ binding site [ion binding]; other site 512565010042 G-X-G motif; other site 512565010043 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565010044 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565010045 DNA binding site [nucleotide binding] 512565010046 domain linker motif; other site 512565010047 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 512565010048 putative dimerization interface [polypeptide binding]; other site 512565010049 putative ligand binding site [chemical binding]; other site 512565010050 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 512565010051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565010052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565010053 homodimer interface [polypeptide binding]; other site 512565010054 catalytic residue [active] 512565010055 EamA-like transporter family; Region: EamA; pfam00892 512565010056 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565010057 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565010058 putative Zn2+ binding site [ion binding]; other site 512565010059 putative DNA binding site [nucleotide binding]; other site 512565010060 dimerization interface [polypeptide binding]; other site 512565010061 AsnC family; Region: AsnC_trans_reg; pfam01037 512565010062 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565010063 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 512565010064 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 512565010065 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565010066 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 512565010067 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 512565010068 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 512565010069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565010070 catalytic loop [active] 512565010071 iron binding site [ion binding]; other site 512565010072 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 512565010073 TIGR03086 family protein; Region: TIGR03086 512565010074 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565010075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565010076 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565010077 NAD(P) binding site [chemical binding]; other site 512565010078 active site 512565010079 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 512565010080 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 512565010081 CAAX protease self-immunity; Region: Abi; pfam02517 512565010082 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 512565010083 nucleoside/Zn binding site; other site 512565010084 dimer interface [polypeptide binding]; other site 512565010085 catalytic motif [active] 512565010086 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565010087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565010088 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565010089 dimerization interface [polypeptide binding]; other site 512565010090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565010091 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565010092 NAD(P) binding site [chemical binding]; other site 512565010093 active site 512565010094 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 512565010095 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565010096 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565010097 Interdomain contacts; other site 512565010098 Cellulose binding domain; Region: CBM_2; pfam00553 512565010099 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 512565010100 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565010101 NAD binding site [chemical binding]; other site 512565010102 catalytic Zn binding site [ion binding]; other site 512565010103 structural Zn binding site [ion binding]; other site 512565010104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565010105 putative DNA binding site [nucleotide binding]; other site 512565010106 putative Zn2+ binding site [ion binding]; other site 512565010107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565010109 putative substrate translocation pore; other site 512565010110 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565010111 MarR family; Region: MarR_2; pfam12802 512565010112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565010113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010114 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 512565010115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010116 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565010117 putative substrate translocation pore; other site 512565010118 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565010119 MarR family; Region: MarR_2; cl17246 512565010120 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 512565010121 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 512565010122 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565010123 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565010124 thymidine kinase; Provisional; Region: PRK04296 512565010125 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 512565010126 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565010127 substrate binding site [chemical binding]; other site 512565010128 ATP binding site [chemical binding]; other site 512565010129 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 512565010130 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 512565010131 D-pathway; other site 512565010132 Putative ubiquinol binding site [chemical binding]; other site 512565010133 Low-spin heme (heme b) binding site [chemical binding]; other site 512565010134 Putative water exit pathway; other site 512565010135 Binuclear center (heme o3/CuB) [ion binding]; other site 512565010136 K-pathway; other site 512565010137 Putative proton exit pathway; other site 512565010138 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 512565010139 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 512565010140 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565010141 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565010142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565010144 Transmembrane secretion effector; Region: MFS_3; pfam05977 512565010145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010146 putative substrate translocation pore; other site 512565010147 CAAX protease self-immunity; Region: Abi; pfam02517 512565010148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565010149 Histidine kinase; Region: HisKA_3; pfam07730 512565010150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010152 active site 512565010153 phosphorylation site [posttranslational modification] 512565010154 intermolecular recognition site; other site 512565010155 dimerization interface [polypeptide binding]; other site 512565010156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010157 DNA binding residues [nucleotide binding] 512565010158 dimerization interface [polypeptide binding]; other site 512565010159 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565010160 GAF domain; Region: GAF_3; pfam13492 512565010161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565010162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565010163 dimer interface [polypeptide binding]; other site 512565010164 phosphorylation site [posttranslational modification] 512565010165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565010166 ATP binding site [chemical binding]; other site 512565010167 Mg2+ binding site [ion binding]; other site 512565010168 G-X-G motif; other site 512565010169 Response regulator receiver domain; Region: Response_reg; pfam00072 512565010170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010171 active site 512565010172 phosphorylation site [posttranslational modification] 512565010173 intermolecular recognition site; other site 512565010174 dimerization interface [polypeptide binding]; other site 512565010175 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565010176 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565010177 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565010178 GAF domain; Region: GAF; pfam01590 512565010179 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565010180 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 512565010181 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565010182 putative active site [active] 512565010183 putative metal binding site [ion binding]; other site 512565010184 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565010185 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 512565010186 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 512565010187 putative NAD(P) binding site [chemical binding]; other site 512565010188 dimer interface [polypeptide binding]; other site 512565010189 AAA ATPase domain; Region: AAA_16; pfam13191 512565010190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010192 DNA binding residues [nucleotide binding] 512565010193 dimerization interface [polypeptide binding]; other site 512565010194 AAA ATPase domain; Region: AAA_16; pfam13191 512565010195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010197 DNA binding residues [nucleotide binding] 512565010198 dimerization interface [polypeptide binding]; other site 512565010199 AAA ATPase domain; Region: AAA_16; pfam13191 512565010200 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010202 DNA binding residues [nucleotide binding] 512565010203 dimerization interface [polypeptide binding]; other site 512565010204 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010206 DNA binding residues [nucleotide binding] 512565010207 dimerization interface [polypeptide binding]; other site 512565010208 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010210 DNA binding residues [nucleotide binding] 512565010211 dimerization interface [polypeptide binding]; other site 512565010212 Major royal jelly protein; Region: MRJP; pfam03022 512565010213 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 512565010214 substrate binding site [chemical binding]; other site 512565010215 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 512565010216 gating phenylalanine in ion channel; other site 512565010217 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565010218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010219 S-adenosylmethionine binding site [chemical binding]; other site 512565010220 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565010221 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565010222 metal binding site [ion binding]; metal-binding site 512565010223 active site 512565010224 I-site; other site 512565010225 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565010226 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 512565010227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565010228 active site 512565010229 motif I; other site 512565010230 motif II; other site 512565010231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565010232 MarR family; Region: MarR; pfam01047 512565010233 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565010234 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 512565010235 Hemerythrin-like domain; Region: Hr-like; cd12108 512565010236 Fe binding site [ion binding]; other site 512565010237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565010238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565010239 metal binding site [ion binding]; metal-binding site 512565010240 active site 512565010241 I-site; other site 512565010242 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010244 putative substrate translocation pore; other site 512565010245 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 512565010246 dimer interface [polypeptide binding]; other site 512565010247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565010248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565010249 DivIVA protein; Region: DivIVA; pfam05103 512565010250 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565010251 large tegument protein UL36; Provisional; Region: PHA03247 512565010252 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 512565010253 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 512565010254 EamA-like transporter family; Region: EamA; pfam00892 512565010255 EamA-like transporter family; Region: EamA; pfam00892 512565010256 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 512565010257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565010258 substrate binding site [chemical binding]; other site 512565010259 oxyanion hole (OAH) forming residues; other site 512565010260 trimer interface [polypeptide binding]; other site 512565010261 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 512565010262 Protease prsW family; Region: PrsW-protease; pfam13367 512565010263 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565010264 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 512565010265 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 512565010266 ligand binding site [chemical binding]; other site 512565010267 homodimer interface [polypeptide binding]; other site 512565010268 NAD(P) binding site [chemical binding]; other site 512565010269 trimer interface B [polypeptide binding]; other site 512565010270 trimer interface A [polypeptide binding]; other site 512565010271 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 512565010272 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 512565010273 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 512565010274 PAS fold; Region: PAS_4; pfam08448 512565010275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565010276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565010277 dimer interface [polypeptide binding]; other site 512565010278 phosphorylation site [posttranslational modification] 512565010279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565010280 ATP binding site [chemical binding]; other site 512565010281 Mg2+ binding site [ion binding]; other site 512565010282 G-X-G motif; other site 512565010283 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 512565010284 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 512565010285 active site 512565010286 dimer interface [polypeptide binding]; other site 512565010287 non-prolyl cis peptide bond; other site 512565010288 insertion regions; other site 512565010289 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 512565010290 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 512565010291 active site 512565010292 non-prolyl cis peptide bond; other site 512565010293 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565010294 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565010295 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565010296 Walker A/P-loop; other site 512565010297 ATP binding site [chemical binding]; other site 512565010298 Q-loop/lid; other site 512565010299 ABC transporter signature motif; other site 512565010300 Walker B; other site 512565010301 D-loop; other site 512565010302 H-loop/switch region; other site 512565010303 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565010304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565010305 dimer interface [polypeptide binding]; other site 512565010306 conserved gate region; other site 512565010307 putative PBP binding loops; other site 512565010308 ABC-ATPase subunit interface; other site 512565010309 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 512565010310 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 512565010311 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565010312 MarR family; Region: MarR_2; pfam12802 512565010313 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565010314 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565010315 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 512565010316 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 512565010317 catalytic residues [active] 512565010318 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 512565010319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010320 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565010321 CHAT domain; Region: CHAT; cl17868 512565010322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010323 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 512565010324 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 512565010325 acetylornithine deacetylase; Validated; Region: PRK06915 512565010326 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 512565010327 metal binding site [ion binding]; metal-binding site 512565010328 dimer interface [polypeptide binding]; other site 512565010329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565010330 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 512565010331 High-affinity nickel-transport protein; Region: NicO; cl00964 512565010332 Transglycosylase; Region: Transgly; pfam00912 512565010333 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 512565010334 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512565010335 hypothetical protein; Provisional; Region: PRK06834 512565010336 hypothetical protein; Provisional; Region: PRK07236 512565010337 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565010338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010339 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565010340 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565010341 DNA binding site [nucleotide binding] 512565010342 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565010343 ligand binding site [chemical binding]; other site 512565010344 dimerization interface [polypeptide binding]; other site 512565010345 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 512565010346 substrate binding site [chemical binding]; other site 512565010347 active site 512565010348 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565010349 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 512565010350 Clp amino terminal domain; Region: Clp_N; pfam02861 512565010351 Clp amino terminal domain; Region: Clp_N; pfam02861 512565010352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565010353 Walker A motif; other site 512565010354 ATP binding site [chemical binding]; other site 512565010355 Walker B motif; other site 512565010356 arginine finger; other site 512565010357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565010358 Walker A motif; other site 512565010359 ATP binding site [chemical binding]; other site 512565010360 Walker B motif; other site 512565010361 arginine finger; other site 512565010362 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 512565010363 FAD dependent oxidoreductase; Region: DAO; pfam01266 512565010364 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565010365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565010366 Walker A motif; other site 512565010367 ATP binding site [chemical binding]; other site 512565010368 Walker B motif; other site 512565010369 arginine finger; other site 512565010370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 512565010371 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565010372 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 512565010373 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565010374 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565010375 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565010376 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 512565010377 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565010378 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565010379 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565010380 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565010381 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 512565010382 enoyl-CoA hydratase; Provisional; Region: PRK07509 512565010383 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565010384 substrate binding site [chemical binding]; other site 512565010385 oxyanion hole (OAH) forming residues; other site 512565010386 trimer interface [polypeptide binding]; other site 512565010387 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 512565010388 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 512565010389 active site 512565010390 FMN binding site [chemical binding]; other site 512565010391 2,4-decadienoyl-CoA binding site; other site 512565010392 catalytic residue [active] 512565010393 4Fe-4S cluster binding site [ion binding]; other site 512565010394 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 512565010395 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 512565010396 aromatic chitin/cellulose binding site residues [chemical binding]; other site 512565010397 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 512565010398 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 512565010399 putative active site [active] 512565010400 Cutinase; Region: Cutinase; pfam01083 512565010401 Transcriptional regulators [Transcription]; Region: GntR; COG1802 512565010402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565010403 DNA-binding site [nucleotide binding]; DNA binding site 512565010404 FCD domain; Region: FCD; pfam07729 512565010405 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565010406 FAD binding domain; Region: FAD_binding_4; pfam01565 512565010407 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 512565010408 Cysteine-rich domain; Region: CCG; pfam02754 512565010409 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565010410 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565010411 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 512565010412 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 512565010413 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 512565010414 active site 512565010415 catalytic triad [active] 512565010416 oxyanion hole [active] 512565010417 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565010418 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565010419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010420 S-adenosylmethionine binding site [chemical binding]; other site 512565010421 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 512565010422 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 512565010423 [4Fe-4S] binding site [ion binding]; other site 512565010424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565010425 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565010426 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565010427 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 512565010428 molybdopterin cofactor binding site; other site 512565010429 nitrate reductase, beta subunit; Region: narH; TIGR01660 512565010430 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 512565010431 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 512565010432 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 512565010433 CHAT domain; Region: CHAT; pfam12770 512565010434 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565010435 structural tetrad; other site 512565010436 Predicted peptidase [General function prediction only]; Region: COG4099 512565010437 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565010438 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 512565010439 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565010440 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 512565010441 active site 512565010442 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 512565010443 active site 512565010444 catalytic site [active] 512565010445 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512565010446 carbohydrate binding site [chemical binding]; other site 512565010447 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 512565010448 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 512565010449 nucleotide binding site [chemical binding]; other site 512565010450 putative NEF/HSP70 interaction site [polypeptide binding]; other site 512565010451 SBD interface [polypeptide binding]; other site 512565010452 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 512565010453 Fatty acid desaturase; Region: FA_desaturase; pfam00487 512565010454 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 512565010455 putative di-iron ligands [ion binding]; other site 512565010456 2-isopropylmalate synthase; Validated; Region: PRK03739 512565010457 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 512565010458 active site 512565010459 catalytic residues [active] 512565010460 metal binding site [ion binding]; metal-binding site 512565010461 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 512565010462 Transcriptional regulators [Transcription]; Region: FadR; COG2186 512565010463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565010464 DNA-binding site [nucleotide binding]; DNA binding site 512565010465 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 512565010466 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 512565010467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565010468 active site 512565010469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565010470 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 512565010471 Sulfatase; Region: Sulfatase; pfam00884 512565010472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565010473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565010474 metal binding site [ion binding]; metal-binding site 512565010475 active site 512565010476 I-site; other site 512565010477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565010478 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 512565010479 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565010480 dimerization interface [polypeptide binding]; other site 512565010481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565010482 dimer interface [polypeptide binding]; other site 512565010483 phosphorylation site [posttranslational modification] 512565010484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565010485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010486 active site 512565010487 phosphorylation site [posttranslational modification] 512565010488 intermolecular recognition site; other site 512565010489 dimerization interface [polypeptide binding]; other site 512565010490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565010491 DNA binding site [nucleotide binding] 512565010492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010494 dimerization interface [polypeptide binding]; other site 512565010495 DNA binding residues [nucleotide binding] 512565010496 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 512565010497 Cellulose binding domain; Region: CBM_2; pfam00553 512565010498 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565010499 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565010500 nucleotide binding site [chemical binding]; other site 512565010501 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565010502 Uncharacterized conserved protein [Function unknown]; Region: COG0397 512565010503 hypothetical protein; Validated; Region: PRK00029 512565010504 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 512565010505 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565010506 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565010507 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 512565010508 active site 512565010509 metal binding site [ion binding]; metal-binding site 512565010510 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565010511 Cellulose binding domain; Region: CBM_2; pfam00553 512565010512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565010513 dimerization interface [polypeptide binding]; other site 512565010514 putative DNA binding site [nucleotide binding]; other site 512565010515 putative Zn2+ binding site [ion binding]; other site 512565010516 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565010517 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565010518 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 512565010519 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 512565010520 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 512565010521 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 512565010522 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 512565010523 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565010524 ligand binding site [chemical binding]; other site 512565010525 dimerization interface [polypeptide binding]; other site 512565010526 Leucine rich repeat; Region: LRR_8; pfam13855 512565010527 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 512565010528 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565010529 G1 box; other site 512565010530 GTP/Mg2+ binding site [chemical binding]; other site 512565010531 G2 box; other site 512565010532 Switch I region; other site 512565010533 G3 box; other site 512565010534 Switch II region; other site 512565010535 G4 box; other site 512565010536 G5 box; other site 512565010537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565010538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565010539 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565010540 Response regulator receiver domain; Region: Response_reg; pfam00072 512565010541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010542 active site 512565010543 phosphorylation site [posttranslational modification] 512565010544 intermolecular recognition site; other site 512565010545 dimerization interface [polypeptide binding]; other site 512565010546 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565010547 ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726 512565010548 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 512565010549 Protein of unknown function DUF58; Region: DUF58; pfam01882 512565010550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565010551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565010552 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 512565010553 NAD(P) binding site [chemical binding]; other site 512565010554 active site 512565010555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565010556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010557 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 512565010558 Integral membrane protein DUF95; Region: DUF95; pfam01944 512565010559 RDD family; Region: RDD; pfam06271 512565010560 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565010561 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 512565010562 active site 512565010563 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565010564 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 512565010565 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 512565010566 putative substrate binding site [chemical binding]; other site 512565010567 active site 512565010568 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565010569 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565010570 NodB motif; other site 512565010571 active site 512565010572 catalytic site [active] 512565010573 metal binding site [ion binding]; metal-binding site 512565010574 PAS domain S-box; Region: sensory_box; TIGR00229 512565010575 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 512565010576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565010577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565010578 dimer interface [polypeptide binding]; other site 512565010579 phosphorylation site [posttranslational modification] 512565010580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565010581 ATP binding site [chemical binding]; other site 512565010582 G-X-G motif; other site 512565010583 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 512565010584 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565010585 NAD binding site [chemical binding]; other site 512565010586 catalytic Zn binding site [ion binding]; other site 512565010587 structural Zn binding site [ion binding]; other site 512565010588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565010589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010590 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 512565010591 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 512565010592 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 512565010593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512565010595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565010596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565010597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565010598 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 512565010599 Domain of unknown function (DUF385); Region: DUF385; cl04387 512565010600 Transcriptional regulator [Transcription]; Region: LytR; COG1316 512565010601 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 512565010602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565010603 Coenzyme A binding pocket [chemical binding]; other site 512565010604 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 512565010605 putative hydrophobic ligand binding site [chemical binding]; other site 512565010606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565010607 dimerization interface [polypeptide binding]; other site 512565010608 putative DNA binding site [nucleotide binding]; other site 512565010609 putative Zn2+ binding site [ion binding]; other site 512565010610 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565010611 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565010612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010613 S-adenosylmethionine binding site [chemical binding]; other site 512565010614 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565010615 TIGR03086 family protein; Region: TIGR03086 512565010616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 512565010617 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 512565010618 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565010619 active site 512565010620 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 512565010621 Epoxide hydrolase N terminus; Region: EHN; pfam06441 512565010622 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565010623 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 512565010624 Class I aldolases; Region: Aldolase_Class_I; cl17187 512565010625 catalytic residue [active] 512565010626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565010627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565010628 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 512565010629 putative dimerization interface [polypeptide binding]; other site 512565010630 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565010631 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565010632 active site 512565010633 Int/Topo IB signature motif; other site 512565010634 DNA binding site [nucleotide binding] 512565010635 Predicted membrane protein [Function unknown]; Region: COG2259 512565010636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 512565010637 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 512565010638 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 512565010639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565010640 DNA-binding site [nucleotide binding]; DNA binding site 512565010641 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565010642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565010643 Walker A/P-loop; other site 512565010644 ATP binding site [chemical binding]; other site 512565010645 Q-loop/lid; other site 512565010646 ABC transporter signature motif; other site 512565010647 Walker B; other site 512565010648 D-loop; other site 512565010649 H-loop/switch region; other site 512565010650 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 512565010651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565010652 NAD(P) binding site [chemical binding]; other site 512565010653 active site 512565010654 Clp amino terminal domain; Region: Clp_N; pfam02861 512565010655 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 512565010656 active site 512565010657 catalytic triad [active] 512565010658 oxyanion hole [active] 512565010659 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 512565010660 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565010661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565010662 Walker A/P-loop; other site 512565010663 ATP binding site [chemical binding]; other site 512565010664 Q-loop/lid; other site 512565010665 ABC transporter signature motif; other site 512565010666 Walker B; other site 512565010667 D-loop; other site 512565010668 H-loop/switch region; other site 512565010669 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565010670 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 512565010671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565010672 Histidine kinase; Region: HisKA_3; pfam07730 512565010673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010675 intermolecular recognition site; other site 512565010676 active site 512565010677 dimerization interface [polypeptide binding]; other site 512565010678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010679 DNA binding residues [nucleotide binding] 512565010680 dimerization interface [polypeptide binding]; other site 512565010681 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 512565010682 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565010683 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565010684 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565010685 DNA binding residues [nucleotide binding] 512565010686 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565010687 Transcriptional regulator PadR-like family; Region: PadR; cl17335 512565010688 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512565010689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565010690 Walker A/P-loop; other site 512565010691 ATP binding site [chemical binding]; other site 512565010692 Q-loop/lid; other site 512565010693 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565010694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565010695 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 512565010696 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 512565010697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565010698 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565010699 Histidine kinase; Region: HisKA_3; pfam07730 512565010700 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565010701 ATP binding site [chemical binding]; other site 512565010702 Mg2+ binding site [ion binding]; other site 512565010703 G-X-G motif; other site 512565010704 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010706 active site 512565010707 phosphorylation site [posttranslational modification] 512565010708 intermolecular recognition site; other site 512565010709 dimerization interface [polypeptide binding]; other site 512565010710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010711 DNA binding residues [nucleotide binding] 512565010712 dimerization interface [polypeptide binding]; other site 512565010713 Predicted transcriptional regulators [Transcription]; Region: COG1725 512565010714 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565010715 DNA-binding site [nucleotide binding]; DNA binding site 512565010716 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 512565010717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010718 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565010719 Dynamin family; Region: Dynamin_N; pfam00350 512565010720 G1 box; other site 512565010721 GTP/Mg2+ binding site [chemical binding]; other site 512565010722 G2 box; other site 512565010723 Switch I region; other site 512565010724 G3 box; other site 512565010725 Switch II region; other site 512565010726 G4 box; other site 512565010727 G5 box; other site 512565010728 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565010729 G1 box; other site 512565010730 GTP/Mg2+ binding site [chemical binding]; other site 512565010731 G2 box; other site 512565010732 Switch I region; other site 512565010733 G3 box; other site 512565010734 Switch II region; other site 512565010735 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565010736 AAA domain; Region: AAA_22; pfam13401 512565010737 G1 box; other site 512565010738 GTP/Mg2+ binding site [chemical binding]; other site 512565010739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010740 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010741 DNA binding residues [nucleotide binding] 512565010742 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 512565010743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565010744 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565010745 putative acyl-acceptor binding pocket; other site 512565010746 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 512565010747 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565010748 active site 512565010749 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 512565010750 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565010751 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565010752 putative sugar binding sites [chemical binding]; other site 512565010753 Q-X-W motif; other site 512565010754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565010755 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 512565010756 active site 512565010757 DNA binding site [nucleotide binding] 512565010758 Int/Topo IB signature motif; other site 512565010759 Cupin; Region: Cupin_6; pfam12852 512565010760 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 512565010761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565010762 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565010763 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565010764 putative NAD(P) binding site [chemical binding]; other site 512565010765 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 512565010766 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565010767 MarR family; Region: MarR; pfam01047 512565010768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565010769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565010770 Coenzyme A binding pocket [chemical binding]; other site 512565010771 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565010772 putative metal binding site [ion binding]; other site 512565010773 putative metal binding site [ion binding]; other site 512565010774 hypothetical protein; Provisional; Region: PRK10621 512565010775 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512565010776 hypothetical protein; Provisional; Region: PRK02487 512565010777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565010778 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565010779 NAD(P) binding site [chemical binding]; other site 512565010780 active site 512565010781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565010782 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 512565010783 CGNR zinc finger; Region: zf-CGNR; pfam11706 512565010784 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 512565010785 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 512565010786 FAD binding domain; Region: FAD_binding_2; pfam00890 512565010787 IucA / IucC family; Region: IucA_IucC; pfam04183 512565010788 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 512565010789 IucA / IucC family; Region: IucA_IucC; pfam04183 512565010790 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 512565010791 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 512565010792 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 512565010793 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565010794 catalytic residue [active] 512565010795 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565010796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010797 S-adenosylmethionine binding site [chemical binding]; other site 512565010798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010799 S-adenosylmethionine binding site [chemical binding]; other site 512565010800 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 512565010801 active site 512565010802 catalytic residues [active] 512565010803 metal binding site [ion binding]; metal-binding site 512565010804 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565010805 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565010806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565010807 DNA binding residues [nucleotide binding] 512565010808 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 512565010809 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 512565010810 glycine dehydrogenase; Provisional; Region: PRK05367 512565010811 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 512565010812 tetramer interface [polypeptide binding]; other site 512565010813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565010814 catalytic residue [active] 512565010815 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 512565010816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565010817 catalytic residue [active] 512565010818 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565010819 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565010820 active site 512565010821 catalytic tetrad [active] 512565010822 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 512565010823 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 512565010824 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565010825 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 512565010826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512565010827 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 512565010828 PAS domain S-box; Region: sensory_box; TIGR00229 512565010829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565010830 putative active site [active] 512565010831 heme pocket [chemical binding]; other site 512565010832 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565010833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565010834 metal binding site [ion binding]; metal-binding site 512565010835 active site 512565010836 I-site; other site 512565010837 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565010838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565010839 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565010840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010841 S-adenosylmethionine binding site [chemical binding]; other site 512565010842 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565010843 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565010844 active site 512565010845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565010846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010847 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 512565010848 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 512565010849 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 512565010850 active site 512565010851 enoyl-CoA hydratase; Provisional; Region: PRK08252 512565010852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565010853 substrate binding site [chemical binding]; other site 512565010854 oxyanion hole (OAH) forming residues; other site 512565010855 trimer interface [polypeptide binding]; other site 512565010856 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 512565010857 acyl-CoA synthetase; Validated; Region: PRK07788 512565010858 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565010859 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 512565010860 acyl-activating enzyme (AAE) consensus motif; other site 512565010861 putative AMP binding site [chemical binding]; other site 512565010862 putative active site [active] 512565010863 putative CoA binding site [chemical binding]; other site 512565010864 DivIVA protein; Region: DivIVA; pfam05103 512565010865 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565010866 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 512565010867 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565010868 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565010869 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 512565010870 putative dimerization interface [polypeptide binding]; other site 512565010871 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 512565010872 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 512565010873 homodimer interface [polypeptide binding]; other site 512565010874 NAD binding pocket [chemical binding]; other site 512565010875 ATP binding pocket [chemical binding]; other site 512565010876 Mg binding site [ion binding]; other site 512565010877 active-site loop [active] 512565010878 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 512565010879 gating phenylalanine in ion channel; other site 512565010880 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 512565010881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 512565010882 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565010883 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565010884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565010885 putative substrate translocation pore; other site 512565010886 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 512565010887 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565010888 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 512565010889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565010890 dimerization interface [polypeptide binding]; other site 512565010891 putative DNA binding site [nucleotide binding]; other site 512565010892 putative Zn2+ binding site [ion binding]; other site 512565010893 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 512565010894 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 512565010895 heme-binding site [chemical binding]; other site 512565010896 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 512565010897 FAD binding pocket [chemical binding]; other site 512565010898 FAD binding motif [chemical binding]; other site 512565010899 phosphate binding motif [ion binding]; other site 512565010900 beta-alpha-beta structure motif; other site 512565010901 NAD binding pocket [chemical binding]; other site 512565010902 Heme binding pocket [chemical binding]; other site 512565010903 Hemerythrin-like domain; Region: Hr-like; cd12108 512565010904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565010905 Histidine kinase; Region: HisKA_3; pfam07730 512565010906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565010907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565010908 active site 512565010909 phosphorylation site [posttranslational modification] 512565010910 intermolecular recognition site; other site 512565010911 dimerization interface [polypeptide binding]; other site 512565010912 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565010913 DNA binding residues [nucleotide binding] 512565010914 dimerization interface [polypeptide binding]; other site 512565010915 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565010916 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 512565010917 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 512565010918 active site 512565010919 substrate binding site [chemical binding]; other site 512565010920 trimer interface [polypeptide binding]; other site 512565010921 CoA binding site [chemical binding]; other site 512565010922 classical (c) SDRs; Region: SDR_c; cd05233 512565010923 NAD(P) binding site [chemical binding]; other site 512565010924 active site 512565010925 hypothetical protein; Provisional; Region: PRK07588 512565010926 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565010927 hypothetical protein; Provisional; Region: PRK07236 512565010928 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 512565010929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565010930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565010931 homodimer interface [polypeptide binding]; other site 512565010932 catalytic residue [active] 512565010933 hypothetical protein; Provisional; Region: PRK08244 512565010934 hypothetical protein; Provisional; Region: PRK07236 512565010935 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565010936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565010937 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565010938 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565010939 active site 512565010940 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565010941 MarR family; Region: MarR_2; pfam12802 512565010942 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565010943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010944 S-adenosylmethionine binding site [chemical binding]; other site 512565010945 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565010946 active site 512565010947 metal binding site [ion binding]; metal-binding site 512565010948 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 512565010949 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 512565010950 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 512565010951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565010952 S-adenosylmethionine binding site [chemical binding]; other site 512565010953 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 512565010954 CGNR zinc finger; Region: zf-CGNR; pfam11706 512565010955 hypothetical protein; Provisional; Region: PRK08201 512565010956 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565010957 metal binding site [ion binding]; metal-binding site 512565010958 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565010959 putative metal binding site [ion binding]; other site 512565010960 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565010961 putative catalytic site [active] 512565010962 putative phosphate binding site [ion binding]; other site 512565010963 putative metal binding site [ion binding]; other site 512565010964 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 512565010965 Cadmium resistance transporter; Region: Cad; pfam03596 512565010966 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512565010967 active site 512565010968 metal binding site [ion binding]; metal-binding site 512565010969 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 512565010970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565010971 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 512565010972 dimerization interface [polypeptide binding]; other site 512565010973 substrate binding pocket [chemical binding]; other site 512565010974 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565010975 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 512565010976 dimer interface [polypeptide binding]; other site 512565010977 active site 512565010978 Coenzyme A transferase; Region: CoA_trans; cl17247 512565010979 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 512565010980 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565010981 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133 512565010982 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 512565010983 Strictosidine synthase; Region: Str_synth; pfam03088 512565010984 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565010985 catalytic core [active] 512565010986 short chain dehydrogenase; Provisional; Region: PRK08251 512565010987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565010988 NAD(P) binding site [chemical binding]; other site 512565010989 active site 512565010990 GAF domain; Region: GAF; pfam01590 512565010991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565010992 PAS domain; Region: PAS_9; pfam13426 512565010993 putative active site [active] 512565010994 heme pocket [chemical binding]; other site 512565010995 GAF domain; Region: GAF; pfam01590 512565010996 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565010997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565010998 dimer interface [polypeptide binding]; other site 512565010999 phosphorylation site [posttranslational modification] 512565011000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565011001 ATP binding site [chemical binding]; other site 512565011002 Mg2+ binding site [ion binding]; other site 512565011003 G-X-G motif; other site 512565011004 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 512565011005 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 512565011006 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 512565011007 Erythromycin esterase; Region: Erythro_esteras; pfam05139 512565011008 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 512565011009 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565011010 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 512565011011 putative active site [active] 512565011012 putative metal-binding site [ion binding]; other site 512565011013 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 512565011014 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 512565011015 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512565011016 active site 512565011017 oxyanion hole [active] 512565011018 catalytic triad [active] 512565011019 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565011020 active site 512565011021 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565011022 short chain dehydrogenase; Provisional; Region: PRK06181 512565011023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565011024 NAD(P) binding site [chemical binding]; other site 512565011025 active site 512565011026 Patatin-like phospholipase; Region: Patatin; pfam01734 512565011027 active site 512565011028 nucleophile elbow; other site 512565011029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565011030 Histidine kinase; Region: HisKA_3; pfam07730 512565011031 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565011033 active site 512565011034 phosphorylation site [posttranslational modification] 512565011035 intermolecular recognition site; other site 512565011036 dimerization interface [polypeptide binding]; other site 512565011037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011038 DNA binding residues [nucleotide binding] 512565011039 dimerization interface [polypeptide binding]; other site 512565011040 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 512565011041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 512565011042 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 512565011043 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565011044 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565011045 putative sugar binding sites [chemical binding]; other site 512565011046 Q-X-W motif; other site 512565011047 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 512565011048 putative FMN binding site [chemical binding]; other site 512565011049 fumarylacetoacetase; Region: PLN02856 512565011050 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 512565011051 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 512565011052 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 512565011053 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 512565011054 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 512565011055 dimer interface [polypeptide binding]; other site 512565011056 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 512565011057 active site 512565011058 Fe binding site [ion binding]; other site 512565011059 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565011060 active site 512565011061 substrate binding sites [chemical binding]; other site 512565011062 short chain dehydrogenase; Provisional; Region: PRK12937 512565011063 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 512565011064 NADP binding site [chemical binding]; other site 512565011065 homodimer interface [polypeptide binding]; other site 512565011066 active site 512565011067 substrate binding site [chemical binding]; other site 512565011068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011070 RibD C-terminal domain; Region: RibD_C; cl17279 512565011071 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512565011072 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 512565011073 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011074 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011075 DNA binding residues [nucleotide binding] 512565011076 dimerization interface [polypeptide binding]; other site 512565011077 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565011078 ligand binding site [chemical binding]; other site 512565011079 flexible hinge region; other site 512565011080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565011081 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565011082 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 512565011083 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 512565011084 SEC-C motif; Region: SEC-C; pfam02810 512565011085 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 512565011086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565011087 S-adenosylmethionine binding site [chemical binding]; other site 512565011088 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 512565011089 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512565011090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 512565011091 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 512565011092 active site 512565011093 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 512565011094 TPP-binding site [chemical binding]; other site 512565011095 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 512565011096 PYR/PP interface [polypeptide binding]; other site 512565011097 dimer interface [polypeptide binding]; other site 512565011098 TPP binding site [chemical binding]; other site 512565011099 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 512565011100 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565011101 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 512565011102 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565011103 putative NAD(P) binding site [chemical binding]; other site 512565011104 catalytic Zn binding site [ion binding]; other site 512565011105 structural Zn binding site [ion binding]; other site 512565011106 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 512565011107 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 512565011108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 512565011109 metal ion-dependent adhesion site (MIDAS); other site 512565011110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565011111 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565011112 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 512565011113 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 512565011114 NAD binding site [chemical binding]; other site 512565011115 homodimer interface [polypeptide binding]; other site 512565011116 homotetramer interface [polypeptide binding]; other site 512565011117 active site 512565011118 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 512565011119 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 512565011120 FMN binding site [chemical binding]; other site 512565011121 substrate binding site [chemical binding]; other site 512565011122 putative catalytic residue [active] 512565011123 enoyl-CoA hydratase; Provisional; Region: PRK06688 512565011124 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565011125 substrate binding site [chemical binding]; other site 512565011126 oxyanion hole (OAH) forming residues; other site 512565011127 trimer interface [polypeptide binding]; other site 512565011128 elongation factor G; Reviewed; Region: PRK13351 512565011129 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565011130 G1 box; other site 512565011131 GTP/Mg2+ binding site [chemical binding]; other site 512565011132 G2 box; other site 512565011133 Switch I region; other site 512565011134 G3 box; other site 512565011135 Switch II region; other site 512565011136 G4 box; other site 512565011137 G5 box; other site 512565011138 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 512565011139 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 512565011140 Elongation factor G C-terminus; Region: EFG_C; pfam00679 512565011141 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565011142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565011143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565011144 DNA binding residues [nucleotide binding] 512565011145 Putative zinc-finger; Region: zf-HC2; pfam13490 512565011146 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 512565011147 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 512565011148 Walker A/P-loop; other site 512565011149 ATP binding site [chemical binding]; other site 512565011150 Q-loop/lid; other site 512565011151 ABC transporter signature motif; other site 512565011152 Walker B; other site 512565011153 D-loop; other site 512565011154 H-loop/switch region; other site 512565011155 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 512565011156 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 512565011157 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565011158 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565011159 Walker A/P-loop; other site 512565011160 ATP binding site [chemical binding]; other site 512565011161 Q-loop/lid; other site 512565011162 ABC transporter signature motif; other site 512565011163 Walker B; other site 512565011164 D-loop; other site 512565011165 H-loop/switch region; other site 512565011166 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 512565011167 FecCD transport family; Region: FecCD; pfam01032 512565011168 ABC-ATPase subunit interface; other site 512565011169 dimer interface [polypeptide binding]; other site 512565011170 putative PBP binding regions; other site 512565011171 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565011172 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565011173 ABC-ATPase subunit interface; other site 512565011174 dimer interface [polypeptide binding]; other site 512565011175 putative PBP binding regions; other site 512565011176 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 512565011177 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565011178 intersubunit interface [polypeptide binding]; other site 512565011179 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 512565011180 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565011181 HAMP domain; Region: HAMP; pfam00672 512565011182 dimerization interface [polypeptide binding]; other site 512565011183 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565011184 dimer interface [polypeptide binding]; other site 512565011185 putative CheW interface [polypeptide binding]; other site 512565011186 Predicted ATPase [General function prediction only]; Region: COG3899 512565011187 AAA ATPase domain; Region: AAA_16; pfam13191 512565011188 Walker A motif; other site 512565011189 ATP binding site [chemical binding]; other site 512565011190 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011192 DNA binding residues [nucleotide binding] 512565011193 dimerization interface [polypeptide binding]; other site 512565011194 ANTAR domain; Region: ANTAR; cl04297 512565011195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011196 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565011197 Predicted integral membrane protein [Function unknown]; Region: COG0392 512565011198 Patatin-like phospholipase; Region: Patatin; pfam01734 512565011199 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 512565011200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565011201 dimerization interface [polypeptide binding]; other site 512565011202 putative DNA binding site [nucleotide binding]; other site 512565011203 putative Zn2+ binding site [ion binding]; other site 512565011204 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565011205 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565011206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011207 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011208 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 512565011209 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 512565011210 FAD binding pocket [chemical binding]; other site 512565011211 FAD binding motif [chemical binding]; other site 512565011212 phosphate binding motif [ion binding]; other site 512565011213 beta-alpha-beta structure motif; other site 512565011214 NAD(p) ribose binding residues [chemical binding]; other site 512565011215 NAD binding pocket [chemical binding]; other site 512565011216 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 512565011217 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565011218 catalytic loop [active] 512565011219 iron binding site [ion binding]; other site 512565011220 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 512565011221 Domain of unknown function DUF59; Region: DUF59; cl00941 512565011222 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 512565011223 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 512565011224 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 512565011225 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 512565011226 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 512565011227 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 512565011228 substrate binding site [chemical binding]; other site 512565011229 dimer interface [polypeptide binding]; other site 512565011230 NADP binding site [chemical binding]; other site 512565011231 catalytic residues [active] 512565011232 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565011233 active site 2 [active] 512565011234 active site 1 [active] 512565011235 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565011236 Phosphotransferase enzyme family; Region: APH; pfam01636 512565011237 active site 512565011238 ATP binding site [chemical binding]; other site 512565011239 Part of AAA domain; Region: AAA_19; pfam13245 512565011240 Family description; Region: UvrD_C_2; pfam13538 512565011241 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565011242 anti sigma factor interaction site; other site 512565011243 regulatory phosphorylation site [posttranslational modification]; other site 512565011244 SprT homologues; Region: SprT; cl01182 512565011245 SprT-like family; Region: SprT-like; pfam10263 512565011246 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565011247 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565011248 metal binding site [ion binding]; metal-binding site 512565011249 active site 512565011250 I-site; other site 512565011251 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 512565011252 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 512565011253 FMN binding site [chemical binding]; other site 512565011254 active site 512565011255 substrate binding site [chemical binding]; other site 512565011256 catalytic residue [active] 512565011257 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565011258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011261 short chain dehydrogenase; Provisional; Region: PRK06197 512565011262 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 512565011263 putative NAD(P) binding site [chemical binding]; other site 512565011264 active site 512565011265 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 512565011266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011268 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 512565011269 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512565011270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565011271 S-adenosylmethionine binding site [chemical binding]; other site 512565011272 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565011273 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 512565011274 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565011275 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565011276 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 512565011277 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 512565011278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 512565011279 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565011280 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565011281 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 512565011282 putative NAD(P) binding site [chemical binding]; other site 512565011283 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565011284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565011285 non-specific DNA binding site [nucleotide binding]; other site 512565011286 salt bridge; other site 512565011287 sequence-specific DNA binding site [nucleotide binding]; other site 512565011288 CHAT domain; Region: CHAT; cl17868 512565011289 AAA ATPase domain; Region: AAA_16; pfam13191 512565011290 AAA domain; Region: AAA_22; pfam13401 512565011291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565011292 TPR repeat; Region: TPR_11; pfam13414 512565011293 binding surface 512565011294 TPR motif; other site 512565011295 TPR repeat; Region: TPR_11; pfam13414 512565011296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565011297 binding surface 512565011298 TPR motif; other site 512565011299 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011300 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565011302 binding surface 512565011303 TPR motif; other site 512565011304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011305 MarR family; Region: MarR_2; pfam12802 512565011306 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565011307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 512565011308 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 512565011309 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 512565011310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565011311 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565011312 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565011313 DNA binding residues [nucleotide binding] 512565011314 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565011315 Ligand Binding Site [chemical binding]; other site 512565011316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565011317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565011318 putative substrate translocation pore; other site 512565011319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565011320 Ligand Binding Site [chemical binding]; other site 512565011321 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 512565011322 putative active site [active] 512565011323 putative catalytic triad [active] 512565011324 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565011325 catalytic residues [active] 512565011326 MarR family; Region: MarR_2; pfam12802 512565011327 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565011328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565011329 dimerization interface [polypeptide binding]; other site 512565011330 putative DNA binding site [nucleotide binding]; other site 512565011331 putative Zn2+ binding site [ion binding]; other site 512565011332 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565011333 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 512565011334 putative NAD(P) binding site [chemical binding]; other site 512565011335 putative substrate binding site [chemical binding]; other site 512565011336 catalytic Zn binding site [ion binding]; other site 512565011337 structural Zn binding site [ion binding]; other site 512565011338 dimer interface [polypeptide binding]; other site 512565011339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565011340 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565011341 salt bridge; other site 512565011342 non-specific DNA binding site [nucleotide binding]; other site 512565011343 sequence-specific DNA binding site [nucleotide binding]; other site 512565011344 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 512565011345 Amb_all domain; Region: Amb_all; smart00656 512565011346 Amb_all domain; Region: Amb_all; smart00656 512565011347 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 512565011348 Amb_all domain; Region: Amb_all; smart00656 512565011349 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 512565011350 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 512565011351 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 512565011352 Proline racemase; Region: Pro_racemase; pfam05544 512565011353 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011354 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011355 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565011356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565011357 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565011358 MarR family; Region: MarR_2; pfam12802 512565011359 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 512565011360 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 512565011361 putative N- and C-terminal domain interface [polypeptide binding]; other site 512565011362 putative active site [active] 512565011363 MgATP binding site [chemical binding]; other site 512565011364 catalytic site [active] 512565011365 metal binding site [ion binding]; metal-binding site 512565011366 putative carbohydrate binding site [chemical binding]; other site 512565011367 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 512565011368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565011369 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 512565011370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565011371 NAD(P) binding site [chemical binding]; other site 512565011372 active site 512565011373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011375 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 512565011376 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565011377 dimerization interface [polypeptide binding]; other site 512565011378 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565011379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565011380 dimer interface [polypeptide binding]; other site 512565011381 putative CheW interface [polypeptide binding]; other site 512565011382 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565011383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565011384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565011385 DNA binding residues [nucleotide binding] 512565011386 Fasciclin domain; Region: Fasciclin; cl02663 512565011387 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565011388 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 512565011389 putative substrate binding site [chemical binding]; other site 512565011390 active site 512565011391 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565011392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565011393 dimer interface [polypeptide binding]; other site 512565011394 conserved gate region; other site 512565011395 putative PBP binding loops; other site 512565011396 ABC-ATPase subunit interface; other site 512565011397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565011398 dimer interface [polypeptide binding]; other site 512565011399 conserved gate region; other site 512565011400 putative PBP binding loops; other site 512565011401 ABC-ATPase subunit interface; other site 512565011402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512565011403 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565011404 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 512565011405 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 512565011406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565011407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565011408 DNA binding site [nucleotide binding] 512565011409 domain linker motif; other site 512565011410 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565011411 dimerization interface [polypeptide binding]; other site 512565011412 ligand binding site [chemical binding]; other site 512565011413 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 512565011414 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 512565011415 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565011416 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 512565011417 RHS Repeat; Region: RHS_repeat; pfam05593 512565011418 RHS Repeat; Region: RHS_repeat; cl11982 512565011419 RHS Repeat; Region: RHS_repeat; cl11982 512565011420 RHS Repeat; Region: RHS_repeat; pfam05593 512565011421 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 512565011422 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 512565011423 protein-splicing catalytic site; other site 512565011424 thioester formation/cholesterol transfer; other site 512565011425 Pretoxin HINT domain; Region: PT-HINT; pfam07591 512565011426 GIY-YIG catalytic domain; Region: GIY-YIG; pfam01541 512565011427 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 512565011428 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 512565011429 Na binding site [ion binding]; other site 512565011430 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 512565011431 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 512565011432 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 512565011433 active site 512565011434 substrate binding site [chemical binding]; other site 512565011435 trimer interface [polypeptide binding]; other site 512565011436 CoA binding site [chemical binding]; other site 512565011437 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 512565011438 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 512565011439 dimer interface [polypeptide binding]; other site 512565011440 active site 512565011441 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565011442 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565011443 Peptidase family M48; Region: Peptidase_M48; cl12018 512565011444 putative lyase; Provisional; Region: PRK09687 512565011445 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 512565011446 Pretoxin HINT domain; Region: PT-HINT; pfam07591 512565011447 Iron permease FTR1 family; Region: FTR1; pfam03239 512565011448 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 512565011449 Imelysin; Region: Peptidase_M75; pfam09375 512565011450 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 512565011451 Penicillinase repressor; Region: Pencillinase_R; cl17580 512565011452 TIR domain; Region: TIR_2; pfam13676 512565011453 AAA ATPase domain; Region: AAA_16; pfam13191 512565011454 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011455 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565011457 binding surface 512565011458 TPR motif; other site 512565011459 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011460 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 512565011461 RibD C-terminal domain; Region: RibD_C; cl17279 512565011462 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565011463 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 512565011464 HEAT repeats; Region: HEAT_2; pfam13646 512565011465 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565011466 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565011467 putative sugar binding sites [chemical binding]; other site 512565011468 Q-X-W motif; other site 512565011469 Cupin domain; Region: Cupin_2; cl17218 512565011470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565011471 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565011472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565011473 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565011474 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565011475 Walker A/P-loop; other site 512565011476 ATP binding site [chemical binding]; other site 512565011477 Q-loop/lid; other site 512565011478 ABC transporter signature motif; other site 512565011479 Walker B; other site 512565011480 D-loop; other site 512565011481 H-loop/switch region; other site 512565011482 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 512565011483 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 512565011484 siderophore binding site; other site 512565011485 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565011486 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565011487 ABC-ATPase subunit interface; other site 512565011488 dimer interface [polypeptide binding]; other site 512565011489 putative PBP binding regions; other site 512565011490 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565011491 ABC-ATPase subunit interface; other site 512565011492 dimer interface [polypeptide binding]; other site 512565011493 putative PBP binding regions; other site 512565011494 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 512565011495 DNA binding residues [nucleotide binding] 512565011496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565011497 dimer interface [polypeptide binding]; other site 512565011498 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 512565011499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565011500 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565011501 active site 512565011502 catalytic tetrad [active] 512565011503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565011504 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565011505 Pleckstrin homology-like domain; Region: PH-like; cl17171 512565011506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565011507 Walker A/P-loop; other site 512565011508 ATP binding site [chemical binding]; other site 512565011509 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 512565011510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565011511 NAD(P) binding site [chemical binding]; other site 512565011512 active site 512565011513 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 512565011514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565011515 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565011516 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565011517 Walker A/P-loop; other site 512565011518 ATP binding site [chemical binding]; other site 512565011519 Q-loop/lid; other site 512565011520 ABC transporter signature motif; other site 512565011521 Walker B; other site 512565011522 D-loop; other site 512565011523 H-loop/switch region; other site 512565011524 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565011525 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565011526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565011527 Histidine kinase; Region: HisKA_3; pfam07730 512565011528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565011529 ATP binding site [chemical binding]; other site 512565011530 Mg2+ binding site [ion binding]; other site 512565011531 G-X-G motif; other site 512565011532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565011534 active site 512565011535 phosphorylation site [posttranslational modification] 512565011536 intermolecular recognition site; other site 512565011537 dimerization interface [polypeptide binding]; other site 512565011538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011539 DNA binding residues [nucleotide binding] 512565011540 dimerization interface [polypeptide binding]; other site 512565011541 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 512565011542 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 512565011543 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 512565011544 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565011545 Coenzyme A binding pocket [chemical binding]; other site 512565011546 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 512565011547 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 512565011548 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565011549 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565011550 Walker A/P-loop; other site 512565011551 ATP binding site [chemical binding]; other site 512565011552 Q-loop/lid; other site 512565011553 ABC transporter signature motif; other site 512565011554 Walker B; other site 512565011555 D-loop; other site 512565011556 H-loop/switch region; other site 512565011557 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 512565011558 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565011559 substrate binding pocket [chemical binding]; other site 512565011560 membrane-bound complex binding site; other site 512565011561 hinge residues; other site 512565011562 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565011563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565011564 dimer interface [polypeptide binding]; other site 512565011565 conserved gate region; other site 512565011566 putative PBP binding loops; other site 512565011567 ABC-ATPase subunit interface; other site 512565011568 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 512565011569 Sulfatase; Region: Sulfatase; pfam00884 512565011570 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512565011571 active site 512565011572 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 512565011573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565011574 active site 512565011575 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565011576 YCII-related domain; Region: YCII; cl00999 512565011577 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 512565011578 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 512565011579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565011580 S-adenosylmethionine binding site [chemical binding]; other site 512565011581 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565011582 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565011583 ATP binding site [chemical binding]; other site 512565011584 Mg2+ binding site [ion binding]; other site 512565011585 G-X-G motif; other site 512565011586 hypothetical protein; Provisional; Region: PRK07588 512565011587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565011588 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565011589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565011590 S-adenosylmethionine binding site [chemical binding]; other site 512565011591 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 512565011592 Protein of unknown function, DUF608; Region: DUF608; pfam04685 512565011593 Methyltransferase domain; Region: Methyltransf_24; pfam13578 512565011594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565011595 S-adenosylmethionine binding site [chemical binding]; other site 512565011596 EXLDI protein; Region: EXLDI; TIGR04342 512565011597 Domain of unknown function (DUF389); Region: DUF389; pfam04087 512565011598 Transcriptional regulator PadR-like family; Region: PadR; cl17335 512565011599 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565011600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565011601 putative DNA binding site [nucleotide binding]; other site 512565011602 putative Zn2+ binding site [ion binding]; other site 512565011603 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565011604 hydrophobic ligand binding site; other site 512565011605 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 512565011606 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 512565011607 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565011608 DDE superfamily endonuclease; Region: DDE_5; pfam13546 512565011609 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565011610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565011611 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565011612 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565011613 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565011614 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 512565011615 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 512565011616 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 512565011617 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 512565011618 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 512565011619 DDE superfamily endonuclease; Region: DDE_5; pfam13546 512565011620 Adaptin N terminal region; Region: Adaptin_N; pfam01602 512565011621 Protein of unknown function (DUF419); Region: DUF419; pfam04237 512565011622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565011623 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565011624 active site 512565011625 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565011626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565011627 S-adenosylmethionine binding site [chemical binding]; other site 512565011628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565011629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565011630 NAD(P) binding site [chemical binding]; other site 512565011631 active site 512565011632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565011633 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 512565011634 putative ADP-binding pocket [chemical binding]; other site 512565011635 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 512565011636 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 512565011637 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 512565011638 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 512565011639 active site 512565011640 TatD related DNase; Region: TatD_DNase; pfam01026 512565011641 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565011642 UbiA prenyltransferase family; Region: UbiA; pfam01040 512565011643 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 512565011644 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 512565011645 YCII-related domain; Region: YCII; cl00999 512565011646 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565011647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565011648 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565011649 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 512565011650 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 512565011651 Transposase domain (DUF772); Region: DUF772; pfam05598 512565011652 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 512565011653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 512565011654 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512565011655 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512565011656 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 512565011657 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 512565011658 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 512565011659 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 512565011660 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565011661 intersubunit interface [polypeptide binding]; other site 512565011662 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 512565011663 metal binding site 2 [ion binding]; metal-binding site 512565011664 putative DNA binding helix; other site 512565011665 metal binding site 1 [ion binding]; metal-binding site 512565011666 dimer interface [polypeptide binding]; other site 512565011667 structural Zn2+ binding site [ion binding]; other site 512565011668 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 512565011669 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 512565011670 dimer interface [polypeptide binding]; other site 512565011671 active site 512565011672 heme binding site [chemical binding]; other site 512565011673 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 512565011674 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 512565011675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565011676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565011677 homodimer interface [polypeptide binding]; other site 512565011678 catalytic residue [active] 512565011679 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565011680 DinB superfamily; Region: DinB_2; pfam12867 512565011681 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 512565011682 CGNR zinc finger; Region: zf-CGNR; pfam11706 512565011683 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 512565011684 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 512565011685 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 512565011686 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565011687 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 512565011688 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565011689 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565011690 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 512565011691 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 512565011692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011694 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 512565011695 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565011696 putative active site [active] 512565011697 putative metal binding site [ion binding]; other site 512565011698 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 512565011699 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 512565011700 DNA binding residues [nucleotide binding] 512565011701 putative dimer interface [polypeptide binding]; other site 512565011702 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 512565011703 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 512565011704 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565011705 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565011706 hypothetical protein; Provisional; Region: PRK08204 512565011707 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565011708 active site 512565011709 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 512565011710 CoA-transferase family III; Region: CoA_transf_3; pfam02515 512565011711 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 512565011712 active site 512565011713 citrylCoA binding site [chemical binding]; other site 512565011714 oxalacetate binding site [chemical binding]; other site 512565011715 coenzyme A binding site [chemical binding]; other site 512565011716 catalytic triad [active] 512565011717 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 512565011718 active site 512565011719 Fe(II) binding site [ion binding]; other site 512565011720 dimer interface [polypeptide binding]; other site 512565011721 tetramer interface [polypeptide binding]; other site 512565011722 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 512565011723 dimer interface [polypeptide binding]; other site 512565011724 tetramer interface [polypeptide binding]; other site 512565011725 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565011726 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565011727 NAD(P) binding site [chemical binding]; other site 512565011728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565011729 Coenzyme A binding pocket [chemical binding]; other site 512565011730 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565011731 anti sigma factor interaction site; other site 512565011732 regulatory phosphorylation site [posttranslational modification]; other site 512565011733 AAA ATPase domain; Region: AAA_16; pfam13191 512565011734 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565011735 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565011736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011738 DNA binding residues [nucleotide binding] 512565011739 dimerization interface [polypeptide binding]; other site 512565011740 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 512565011741 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565011742 substrate binding pocket [chemical binding]; other site 512565011743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011745 DNA binding residues [nucleotide binding] 512565011746 dimerization interface [polypeptide binding]; other site 512565011747 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 512565011748 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565011749 substrate binding pocket [chemical binding]; other site 512565011750 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565011751 coproporphyrinogen III oxidase; Validated; Region: PRK08208 512565011752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565011753 FeS/SAM binding site; other site 512565011754 HemN C-terminal domain; Region: HemN_C; pfam06969 512565011755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565011756 Radical SAM superfamily; Region: Radical_SAM; pfam04055 512565011757 FeS/SAM binding site; other site 512565011758 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 512565011759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565011760 FeS/SAM binding site; other site 512565011761 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 512565011762 HEXXH motif domain; Region: mod_HExxH; TIGR04267 512565011763 TIR domain; Region: TIR_2; cl17458 512565011764 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 512565011765 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 512565011766 P-loop; other site 512565011767 Magnesium ion binding site [ion binding]; other site 512565011768 AAA ATPase domain; Region: AAA_16; pfam13191 512565011769 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011771 Tetratricopeptide repeat; Region: TPR_10; pfam13374 512565011772 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011773 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565011775 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 512565011776 oxyanion hole [active] 512565011777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565011778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565011779 metal binding site [ion binding]; metal-binding site 512565011780 active site 512565011781 I-site; other site 512565011782 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 512565011783 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 512565011784 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 512565011785 nucleotide binding pocket [chemical binding]; other site 512565011786 K-X-D-G motif; other site 512565011787 catalytic site [active] 512565011788 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 512565011789 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 512565011790 Dimer interface [polypeptide binding]; other site 512565011791 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565011792 MarR family; Region: MarR_2; cl17246 512565011793 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 512565011794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565011795 putative substrate translocation pore; other site 512565011796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565011797 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565011798 active site 512565011799 catalytic tetrad [active] 512565011800 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565011801 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512565011802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565011803 ATP binding site [chemical binding]; other site 512565011804 putative Mg++ binding site [ion binding]; other site 512565011805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565011806 nucleotide binding region [chemical binding]; other site 512565011807 ATP-binding site [chemical binding]; other site 512565011808 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 512565011809 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565011810 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565011811 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565011812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565011813 dimer interface [polypeptide binding]; other site 512565011814 conserved gate region; other site 512565011815 putative PBP binding loops; other site 512565011816 ABC-ATPase subunit interface; other site 512565011817 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565011818 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565011819 Walker A/P-loop; other site 512565011820 ATP binding site [chemical binding]; other site 512565011821 Q-loop/lid; other site 512565011822 ABC transporter signature motif; other site 512565011823 Walker B; other site 512565011824 D-loop; other site 512565011825 H-loop/switch region; other site 512565011826 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 512565011827 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 512565011828 AAA ATPase domain; Region: AAA_16; pfam13191 512565011829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011831 DNA binding residues [nucleotide binding] 512565011832 dimerization interface [polypeptide binding]; other site 512565011833 potential frameshift: common BLAST hit: gi|331698097|ref|YP_004334336.1| dihydrolipoyl dehydrogenase 512565011834 mercuric reductase; Validated; Region: PRK06370 512565011835 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 512565011836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565011837 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565011838 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565011839 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565011840 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 512565011841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565011842 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565011843 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565011844 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565011845 NAD(P) binding site [chemical binding]; other site 512565011846 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 512565011847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565011848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565011849 NAD(P) binding site [chemical binding]; other site 512565011850 active site 512565011851 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565011852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565011853 substrate binding site [chemical binding]; other site 512565011854 oxyanion hole (OAH) forming residues; other site 512565011855 trimer interface [polypeptide binding]; other site 512565011856 Epoxide hydrolase N terminus; Region: EHN; pfam06441 512565011857 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565011858 Epoxide hydrolase N terminus; Region: EHN; pfam06441 512565011859 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565011860 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 512565011861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 512565011862 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512565011863 oxyanion hole [active] 512565011864 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 512565011865 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565011866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565011867 active site 512565011868 phosphorylation site [posttranslational modification] 512565011869 intermolecular recognition site; other site 512565011870 dimerization interface [polypeptide binding]; other site 512565011871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565011872 DNA binding residues [nucleotide binding] 512565011873 dimerization interface [polypeptide binding]; other site 512565011874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565011875 Histidine kinase; Region: HisKA_3; pfam07730 512565011876 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565011877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565011878 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565011879 Walker A/P-loop; other site 512565011880 ATP binding site [chemical binding]; other site 512565011881 Q-loop/lid; other site 512565011882 ABC transporter signature motif; other site 512565011883 Walker B; other site 512565011884 D-loop; other site 512565011885 H-loop/switch region; other site 512565011886 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 512565011887 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 512565011888 homodimer interface [polypeptide binding]; other site 512565011889 substrate-cofactor binding pocket; other site 512565011890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565011891 catalytic residue [active] 512565011892 Transcriptional regulators [Transcription]; Region: FadR; COG2186 512565011893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565011894 DNA-binding site [nucleotide binding]; DNA binding site 512565011895 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 512565011896 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 512565011897 RibD C-terminal domain; Region: RibD_C; cl17279 512565011898 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565011899 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 512565011900 substrate binding site [chemical binding]; other site 512565011901 ATP binding site [chemical binding]; other site 512565011902 Entner-Doudoroff aldolase; Region: eda; TIGR01182 512565011903 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 512565011904 active site 512565011905 intersubunit interface [polypeptide binding]; other site 512565011906 catalytic residue [active] 512565011907 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 512565011908 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 512565011909 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 512565011910 glucuronate isomerase; Reviewed; Region: PRK02925 512565011911 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 512565011912 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 512565011913 galactarate dehydratase; Region: galactar-dH20; TIGR03248 512565011914 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 512565011915 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512565011916 conserved cys residue [active] 512565011917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565011918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565011919 DNA binding site [nucleotide binding] 512565011920 domain linker motif; other site 512565011921 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565011922 ligand binding site [chemical binding]; other site 512565011923 dimerization interface [polypeptide binding]; other site 512565011924 Proteins of 100 residues with WXG; Region: WXG100; cl02005 512565011925 Lamin Tail Domain; Region: LTD; pfam00932 512565011926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565011927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565011928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565011929 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 512565011930 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565011931 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 512565011932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565011933 catalytic residue [active] 512565011934 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565011935 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 512565011936 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565011937 sugar binding site [chemical binding]; other site 512565011938 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565011939 sugar binding site [chemical binding]; other site 512565011940 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565011941 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 512565011942 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512565011943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565011944 Coenzyme A binding pocket [chemical binding]; other site 512565011945 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565011946 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565011947 structural tetrad; other site 512565011948 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565011949 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565011950 structural tetrad; other site 512565011951 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 512565011952 homodimer interface [polypeptide binding]; other site 512565011953 metal binding site [ion binding]; metal-binding site 512565011954 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 512565011955 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 512565011956 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 512565011957 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 512565011958 lipoyl attachment site [posttranslational modification]; other site 512565011959 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 512565011960 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 512565011961 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 512565011962 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565011963 anti sigma factor interaction site; other site 512565011964 regulatory phosphorylation site [posttranslational modification]; other site 512565011965 PAS domain; Region: PAS_9; pfam13426 512565011966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565011967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565011968 dimer interface [polypeptide binding]; other site 512565011969 phosphorylation site [posttranslational modification] 512565011970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565011971 ATP binding site [chemical binding]; other site 512565011972 Mg2+ binding site [ion binding]; other site 512565011973 G-X-G motif; other site 512565011974 Response regulator receiver domain; Region: Response_reg; pfam00072 512565011975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565011976 active site 512565011977 phosphorylation site [posttranslational modification] 512565011978 intermolecular recognition site; other site 512565011979 dimerization interface [polypeptide binding]; other site 512565011980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565011981 PAS domain; Region: PAS_9; pfam13426 512565011982 putative active site [active] 512565011983 heme pocket [chemical binding]; other site 512565011984 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565011985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565011986 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565011987 Mg2+ binding site [ion binding]; other site 512565011988 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565011989 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 512565011990 Nitronate monooxygenase; Region: NMO; pfam03060 512565011991 FMN binding site [chemical binding]; other site 512565011992 substrate binding site [chemical binding]; other site 512565011993 putative catalytic residue [active] 512565011994 FtsX-like permease family; Region: FtsX; pfam02687 512565011995 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565011996 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565011997 Walker A/P-loop; other site 512565011998 ATP binding site [chemical binding]; other site 512565011999 Q-loop/lid; other site 512565012000 ABC transporter signature motif; other site 512565012001 Walker B; other site 512565012002 D-loop; other site 512565012003 H-loop/switch region; other site 512565012004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565012005 DNA-binding site [nucleotide binding]; DNA binding site 512565012006 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565012007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012008 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565012009 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565012010 putative catalytic site [active] 512565012011 putative metal binding site [ion binding]; other site 512565012012 putative phosphate binding site [ion binding]; other site 512565012013 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 512565012014 hypothetical protein; Provisional; Region: PRK06762 512565012015 AAA domain; Region: AAA_33; pfam13671 512565012016 tetracycline repressor protein TetR; Provisional; Region: PRK13756 512565012017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012018 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565012019 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 512565012020 active site 512565012021 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565012022 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565012023 putative sugar binding sites [chemical binding]; other site 512565012024 Q-X-W motif; other site 512565012025 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 512565012026 putative substrate binding site [chemical binding]; other site 512565012027 active site 512565012028 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 512565012029 Ca binding site [ion binding]; other site 512565012030 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 512565012031 nudix motif; other site 512565012032 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 512565012033 Chromate transporter; Region: Chromate_transp; pfam02417 512565012034 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 512565012035 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512565012036 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 512565012037 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512565012038 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 512565012039 yiaA/B two helix domain; Region: YiaAB; cl01759 512565012040 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565012041 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565012042 HTH domain; Region: HTH_11; pfam08279 512565012043 WYL domain; Region: WYL; pfam13280 512565012044 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 512565012045 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 512565012046 TPP-binding site [chemical binding]; other site 512565012047 tetramer interface [polypeptide binding]; other site 512565012048 heterodimer interface [polypeptide binding]; other site 512565012049 phosphorylation loop region [posttranslational modification] 512565012050 adenosine deaminase; Provisional; Region: PRK09358 512565012051 active site 512565012052 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 512565012053 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 512565012054 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565012055 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565012056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012058 active site 512565012059 phosphorylation site [posttranslational modification] 512565012060 intermolecular recognition site; other site 512565012061 dimerization interface [polypeptide binding]; other site 512565012062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012063 DNA binding residues [nucleotide binding] 512565012064 dimerization interface [polypeptide binding]; other site 512565012065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565012066 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 512565012067 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565012068 Walker A/P-loop; other site 512565012069 ATP binding site [chemical binding]; other site 512565012070 Q-loop/lid; other site 512565012071 ABC transporter signature motif; other site 512565012072 Walker B; other site 512565012073 D-loop; other site 512565012074 H-loop/switch region; other site 512565012075 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 512565012076 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 512565012077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565012078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565012079 dimer interface [polypeptide binding]; other site 512565012080 conserved gate region; other site 512565012081 putative PBP binding loops; other site 512565012082 ABC-ATPase subunit interface; other site 512565012083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565012084 dimer interface [polypeptide binding]; other site 512565012085 conserved gate region; other site 512565012086 ABC-ATPase subunit interface; other site 512565012087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565012088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512565012089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565012090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565012091 DNA binding site [nucleotide binding] 512565012092 domain linker motif; other site 512565012093 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565012094 ligand binding site [chemical binding]; other site 512565012095 dimerization interface [polypeptide binding]; other site 512565012096 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565012097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565012098 DNA binding site [nucleotide binding] 512565012099 domain linker motif; other site 512565012100 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565012101 dimerization interface [polypeptide binding]; other site 512565012102 ligand binding site [chemical binding]; other site 512565012103 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 512565012104 Repair protein; Region: Repair_PSII; pfam04536 512565012105 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 512565012106 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 512565012107 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 512565012108 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565012109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565012110 dimer interface [polypeptide binding]; other site 512565012111 conserved gate region; other site 512565012112 putative PBP binding loops; other site 512565012113 ABC-ATPase subunit interface; other site 512565012114 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 512565012115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565012116 dimer interface [polypeptide binding]; other site 512565012117 conserved gate region; other site 512565012118 putative PBP binding loops; other site 512565012119 ABC-ATPase subunit interface; other site 512565012120 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 512565012121 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565012122 Walker A/P-loop; other site 512565012123 ATP binding site [chemical binding]; other site 512565012124 Q-loop/lid; other site 512565012125 ABC transporter signature motif; other site 512565012126 Walker B; other site 512565012127 D-loop; other site 512565012128 H-loop/switch region; other site 512565012129 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565012130 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 512565012131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565012132 Walker A/P-loop; other site 512565012133 ATP binding site [chemical binding]; other site 512565012134 Q-loop/lid; other site 512565012135 ABC transporter signature motif; other site 512565012136 Walker B; other site 512565012137 D-loop; other site 512565012138 H-loop/switch region; other site 512565012139 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565012140 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565012141 putative catalytic site [active] 512565012142 putative metal binding site [ion binding]; other site 512565012143 putative phosphate binding site [ion binding]; other site 512565012144 Family description; Region: VCBS; pfam13517 512565012145 Family description; Region: VCBS; pfam13517 512565012146 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 512565012147 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 512565012148 active site 512565012149 FMN binding site [chemical binding]; other site 512565012150 substrate binding site [chemical binding]; other site 512565012151 3Fe-4S cluster binding site [ion binding]; other site 512565012152 PRC-barrel domain; Region: PRC; pfam05239 512565012153 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 512565012154 MASE1; Region: MASE1; cl17823 512565012155 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565012156 PAS domain; Region: PAS; smart00091 512565012157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565012158 dimer interface [polypeptide binding]; other site 512565012159 phosphorylation site [posttranslational modification] 512565012160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565012161 ATP binding site [chemical binding]; other site 512565012162 Mg2+ binding site [ion binding]; other site 512565012163 G-X-G motif; other site 512565012164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565012165 putative active site [active] 512565012166 heme pocket [chemical binding]; other site 512565012167 GAF domain; Region: GAF; pfam01590 512565012168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565012169 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565012170 dimer interface [polypeptide binding]; other site 512565012171 phosphorylation site [posttranslational modification] 512565012172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565012173 ATP binding site [chemical binding]; other site 512565012174 Mg2+ binding site [ion binding]; other site 512565012175 G-X-G motif; other site 512565012176 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 512565012177 dimanganese center [ion binding]; other site 512565012178 manganese transport protein MntH; Reviewed; Region: PRK00701 512565012179 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 512565012180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012182 active site 512565012183 phosphorylation site [posttranslational modification] 512565012184 intermolecular recognition site; other site 512565012185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 512565012186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565012187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 512565012188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565012189 Mg2+ binding site [ion binding]; other site 512565012190 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565012191 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565012192 anti sigma factor interaction site; other site 512565012193 regulatory phosphorylation site [posttranslational modification]; other site 512565012194 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565012195 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565012196 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 512565012197 High-affinity nickel-transport protein; Region: NicO; cl00964 512565012198 High-affinity nickel-transport protein; Region: NicO; cl00964 512565012199 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 512565012200 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565012201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565012202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565012203 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565012204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565012205 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565012206 active site 512565012207 catalytic tetrad [active] 512565012208 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 512565012209 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 512565012210 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565012211 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 512565012212 Ligand binding site; other site 512565012213 Putative Catalytic site; other site 512565012214 DXD motif; other site 512565012215 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 512565012216 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 512565012217 putative active site [active] 512565012218 catalytic triad [active] 512565012219 putative dimer interface [polypeptide binding]; other site 512565012220 Part of AAA domain; Region: AAA_19; pfam13245 512565012221 Family description; Region: UvrD_C_2; pfam13538 512565012222 MutL protein; Region: MutL; pfam13941 512565012223 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565012224 active site 2 [active] 512565012225 B12 binding domain; Region: B12-binding; pfam02310 512565012226 B12 binding site [chemical binding]; other site 512565012227 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 512565012228 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 512565012229 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565012230 active site 512565012231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 512565012232 CsbD-like; Region: CsbD; pfam05532 512565012233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565012234 S-adenosylmethionine binding site [chemical binding]; other site 512565012235 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 512565012236 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565012237 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565012238 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 512565012239 dimerization interface [polypeptide binding]; other site 512565012240 substrate binding pocket [chemical binding]; other site 512565012241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565012242 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565012243 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 512565012244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565012245 putative DNA binding site [nucleotide binding]; other site 512565012246 putative Zn2+ binding site [ion binding]; other site 512565012247 AsnC family; Region: AsnC_trans_reg; pfam01037 512565012248 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565012249 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565012250 active site 512565012251 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012253 active site 512565012254 phosphorylation site [posttranslational modification] 512565012255 intermolecular recognition site; other site 512565012256 dimerization interface [polypeptide binding]; other site 512565012257 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012258 DNA binding residues [nucleotide binding] 512565012259 dimerization interface [polypeptide binding]; other site 512565012260 Histidine kinase; Region: HisKA_3; pfam07730 512565012261 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565012262 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565012263 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565012264 Walker A/P-loop; other site 512565012265 ATP binding site [chemical binding]; other site 512565012266 Q-loop/lid; other site 512565012267 ABC transporter signature motif; other site 512565012268 Walker B; other site 512565012269 D-loop; other site 512565012270 H-loop/switch region; other site 512565012271 FtsX-like permease family; Region: FtsX; pfam02687 512565012272 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565012273 FtsX-like permease family; Region: FtsX; pfam02687 512565012274 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565012275 5'-3' exonuclease; Region: 53EXOc; smart00475 512565012276 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 512565012277 active site 512565012278 metal binding site 1 [ion binding]; metal-binding site 512565012279 putative 5' ssDNA interaction site; other site 512565012280 metal binding site 3; metal-binding site 512565012281 metal binding site 2 [ion binding]; metal-binding site 512565012282 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 512565012283 putative DNA binding site [nucleotide binding]; other site 512565012284 putative metal binding site [ion binding]; other site 512565012285 PAS domain S-box; Region: sensory_box; TIGR00229 512565012286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565012287 putative active site [active] 512565012288 heme pocket [chemical binding]; other site 512565012289 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565012290 metal binding site [ion binding]; metal-binding site 512565012291 active site 512565012292 I-site; other site 512565012293 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565012294 Predicted acetyltransferase [General function prediction only]; Region: COG3393 512565012295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565012296 Coenzyme A binding pocket [chemical binding]; other site 512565012297 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 512565012298 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565012299 active site 512565012300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565012301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565012302 metal binding site [ion binding]; metal-binding site 512565012303 active site 512565012304 I-site; other site 512565012305 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512565012306 active site 512565012307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565012308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565012309 metal binding site [ion binding]; metal-binding site 512565012310 active site 512565012311 I-site; other site 512565012312 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565012313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565012314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565012315 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 512565012316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 512565012317 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 512565012318 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 512565012319 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 512565012320 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565012321 NAD(P) binding site [chemical binding]; other site 512565012322 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565012323 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 512565012324 sugar binding site [chemical binding]; other site 512565012325 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 512565012326 Cupin; Region: Cupin_6; pfam12852 512565012327 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565012328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565012329 NmrA-like family; Region: NmrA; pfam05368 512565012330 NAD(P) binding site [chemical binding]; other site 512565012331 active site 512565012332 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 512565012333 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 512565012334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565012335 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 512565012336 NAD(P) binding site [chemical binding]; other site 512565012337 active site 512565012338 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 512565012339 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 512565012340 Zn binding site [ion binding]; other site 512565012341 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565012342 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565012343 active site 512565012344 catalytic tetrad [active] 512565012345 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 512565012346 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565012347 DNA binding residues [nucleotide binding] 512565012348 putative dimer interface [polypeptide binding]; other site 512565012349 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565012350 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 512565012351 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 512565012352 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 512565012353 active site 512565012354 catalytic site [active] 512565012355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565012356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565012357 putative substrate translocation pore; other site 512565012358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565012359 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 512565012360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 512565012361 dimerization interface [polypeptide binding]; other site 512565012362 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565012363 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565012364 dimer interface [polypeptide binding]; other site 512565012365 putative CheW interface [polypeptide binding]; other site 512565012366 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565012367 Secretory lipase; Region: LIP; pfam03583 512565012368 Erythromycin esterase; Region: Erythro_esteras; pfam05139 512565012369 PAS fold; Region: PAS_3; pfam08447 512565012370 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 512565012371 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565012372 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 512565012373 PemK-like protein; Region: PemK; pfam02452 512565012374 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565012375 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565012376 metal binding site [ion binding]; metal-binding site 512565012377 active site 512565012378 I-site; other site 512565012379 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 512565012380 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 512565012381 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 512565012382 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565012383 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565012384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565012385 metal binding site [ion binding]; metal-binding site 512565012386 active site 512565012387 I-site; other site 512565012388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565012389 phosphoglucomutase; Validated; Region: PRK07564 512565012390 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 512565012391 active site 512565012392 substrate binding site [chemical binding]; other site 512565012393 metal binding site [ion binding]; metal-binding site 512565012394 CopC domain; Region: CopC; cl01012 512565012395 Copper resistance protein D; Region: CopD; cl00563 512565012396 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565012397 anti sigma factor interaction site; other site 512565012398 regulatory phosphorylation site [posttranslational modification]; other site 512565012399 hypothetical protein; Validated; Region: PRK02101 512565012400 MMPL family; Region: MMPL; pfam03176 512565012401 MMPL family; Region: MMPL; pfam03176 512565012402 Uncharacterized conserved protein (DUF2039); Region: DUF2039; pfam10217 512565012403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565012404 NAD(P) binding site [chemical binding]; other site 512565012405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565012406 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 512565012407 active site 512565012408 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 512565012409 Uncharacterized conserved protein [Function unknown]; Region: COG4279 512565012410 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 512565012411 SNF2 Helicase protein; Region: DUF3670; pfam12419 512565012412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565012413 putative Mg++ binding site [ion binding]; other site 512565012414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565012415 nucleotide binding region [chemical binding]; other site 512565012416 ATP-binding site [chemical binding]; other site 512565012417 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 512565012418 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565012419 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 512565012420 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 512565012421 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 512565012422 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565012423 Cytochrome P450; Region: p450; cl12078 512565012424 Cytochrome P450; Region: p450; cl12078 512565012425 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565012426 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565012427 anti sigma factor interaction site; other site 512565012428 regulatory phosphorylation site [posttranslational modification]; other site 512565012429 amino acid transporter; Region: 2A0306; TIGR00909 512565012430 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 512565012431 Universal stress protein family; Region: Usp; pfam00582 512565012432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565012433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565012434 active site 512565012435 ATP binding site [chemical binding]; other site 512565012436 substrate binding site [chemical binding]; other site 512565012437 activation loop (A-loop); other site 512565012438 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 512565012439 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 512565012440 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 512565012441 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512565012442 active site 512565012443 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 512565012444 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565012445 putative active site [active] 512565012446 putative metal binding site [ion binding]; other site 512565012447 potential frameshift: common BLAST hit: gi|158315627|ref|YP_001508135.1| transposase IS4 family protein 512565012448 Transposase domain (DUF772); Region: DUF772; pfam05598 512565012449 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 512565012450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565012451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012452 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512565012453 Walker A/P-loop; other site 512565012454 ATP binding site [chemical binding]; other site 512565012455 Q-loop/lid; other site 512565012456 ABC transporter signature motif; other site 512565012457 Walker B; other site 512565012458 D-loop; other site 512565012459 H-loop/switch region; other site 512565012460 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512565012461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012462 Walker A/P-loop; other site 512565012463 ATP binding site [chemical binding]; other site 512565012464 Q-loop/lid; other site 512565012465 ABC transporter signature motif; other site 512565012466 Walker B; other site 512565012467 D-loop; other site 512565012468 H-loop/switch region; other site 512565012469 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565012470 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 512565012471 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565012472 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 512565012473 putative heme binding site [chemical binding]; other site 512565012474 putative substrate binding site [chemical binding]; other site 512565012475 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512565012476 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512565012477 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565012478 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565012479 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512565012480 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565012481 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565012482 Walker A/P-loop; other site 512565012483 ATP binding site [chemical binding]; other site 512565012484 Q-loop/lid; other site 512565012485 ABC transporter signature motif; other site 512565012486 Walker B; other site 512565012487 D-loop; other site 512565012488 H-loop/switch region; other site 512565012489 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565012490 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565012491 TM-ABC transporter signature motif; other site 512565012492 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 512565012493 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 512565012494 putative ligand binding site [chemical binding]; other site 512565012495 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565012496 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 512565012497 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 512565012498 tetrameric interface [polypeptide binding]; other site 512565012499 NAD binding site [chemical binding]; other site 512565012500 catalytic residues [active] 512565012501 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 512565012502 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 512565012503 PYR/PP interface [polypeptide binding]; other site 512565012504 dimer interface [polypeptide binding]; other site 512565012505 TPP binding site [chemical binding]; other site 512565012506 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512565012507 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 512565012508 TPP-binding site; other site 512565012509 KduI/IolB family; Region: KduI; pfam04962 512565012510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565012511 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512565012512 Coenzyme A binding pocket [chemical binding]; other site 512565012513 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 512565012514 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 512565012515 Integral membrane protein TerC family; Region: TerC; cl10468 512565012516 AAA ATPase domain; Region: AAA_16; pfam13191 512565012517 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012518 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012519 DNA binding residues [nucleotide binding] 512565012520 dimerization interface [polypeptide binding]; other site 512565012521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565012522 FtsX-like permease family; Region: FtsX; pfam02687 512565012523 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565012524 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565012525 Walker A/P-loop; other site 512565012526 ATP binding site [chemical binding]; other site 512565012527 Q-loop/lid; other site 512565012528 ABC transporter signature motif; other site 512565012529 Walker B; other site 512565012530 D-loop; other site 512565012531 H-loop/switch region; other site 512565012532 HlyD family secretion protein; Region: HlyD_3; pfam13437 512565012533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565012534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565012535 dimerization interface [polypeptide binding]; other site 512565012536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565012537 dimer interface [polypeptide binding]; other site 512565012538 phosphorylation site [posttranslational modification] 512565012539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565012540 ATP binding site [chemical binding]; other site 512565012541 Mg2+ binding site [ion binding]; other site 512565012542 G-X-G motif; other site 512565012543 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565012544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012545 active site 512565012546 phosphorylation site [posttranslational modification] 512565012547 intermolecular recognition site; other site 512565012548 dimerization interface [polypeptide binding]; other site 512565012549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565012550 DNA binding site [nucleotide binding] 512565012551 HlyD family secretion protein; Region: HlyD_3; pfam13437 512565012552 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565012553 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565012554 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012556 DNA binding residues [nucleotide binding] 512565012557 dimerization interface [polypeptide binding]; other site 512565012558 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565012559 catalytic core [active] 512565012560 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 512565012561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565012562 S-adenosylmethionine binding site [chemical binding]; other site 512565012563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565012564 S-adenosylmethionine binding site [chemical binding]; other site 512565012565 Isochorismatase family; Region: Isochorismatase; pfam00857 512565012566 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 512565012567 catalytic triad [active] 512565012568 conserved cis-peptide bond; other site 512565012569 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565012570 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565012571 DNA binding site [nucleotide binding] 512565012572 domain linker motif; other site 512565012573 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565012574 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565012575 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 512565012576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 512565012577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565012579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012580 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565012581 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565012582 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565012583 RHS Repeat; Region: RHS_repeat; pfam05593 512565012584 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565012585 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 512565012586 RHS Repeat; Region: RHS_repeat; pfam05593 512565012587 RHS Repeat; Region: RHS_repeat; pfam05593 512565012588 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565012589 RHS Repeat; Region: RHS_repeat; pfam05593 512565012590 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565012591 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 512565012592 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 512565012593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565012594 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565012595 active site 512565012596 ATP binding site [chemical binding]; other site 512565012597 substrate binding site [chemical binding]; other site 512565012598 activation loop (A-loop); other site 512565012599 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012601 active site 512565012602 phosphorylation site [posttranslational modification] 512565012603 intermolecular recognition site; other site 512565012604 dimerization interface [polypeptide binding]; other site 512565012605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012606 DNA binding residues [nucleotide binding] 512565012607 dimerization interface [polypeptide binding]; other site 512565012608 Putative sensor; Region: Sensor; pfam13796 512565012609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565012610 Histidine kinase; Region: HisKA_3; pfam07730 512565012611 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 512565012612 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565012613 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 512565012614 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 512565012615 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565012616 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565012617 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 512565012618 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 512565012619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565012620 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 512565012621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012622 Walker A/P-loop; other site 512565012623 ATP binding site [chemical binding]; other site 512565012624 Q-loop/lid; other site 512565012625 ABC transporter signature motif; other site 512565012626 Walker B; other site 512565012627 D-loop; other site 512565012628 H-loop/switch region; other site 512565012629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565012630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012631 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 512565012632 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 512565012633 phosphopeptide binding site; other site 512565012634 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 512565012635 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565012636 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 512565012637 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565012638 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 512565012639 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 512565012640 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 512565012641 putative active site [active] 512565012642 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 512565012643 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 512565012644 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 512565012645 active site 512565012646 dimer interface [polypeptide binding]; other site 512565012647 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 512565012648 dimer interface [polypeptide binding]; other site 512565012649 active site 512565012650 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 512565012651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 512565012652 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 512565012653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565012654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565012655 dimer interface [polypeptide binding]; other site 512565012656 conserved gate region; other site 512565012657 putative PBP binding loops; other site 512565012658 ABC-ATPase subunit interface; other site 512565012659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565012660 putative PBP binding loops; other site 512565012661 ABC-ATPase subunit interface; other site 512565012662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565012663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565012664 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565012665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565012666 DNA binding site [nucleotide binding] 512565012667 domain linker motif; other site 512565012668 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565012669 dimerization interface [polypeptide binding]; other site 512565012670 ligand binding site [chemical binding]; other site 512565012671 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 512565012672 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 512565012673 substrate binding site [chemical binding]; other site 512565012674 active site 512565012675 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512565012676 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 512565012677 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565012678 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 512565012679 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512565012680 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512565012681 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 512565012682 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 512565012683 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 512565012684 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 512565012685 active site 512565012686 dimer interface [polypeptide binding]; other site 512565012687 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565012688 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 512565012689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012691 active site 512565012692 phosphorylation site [posttranslational modification] 512565012693 intermolecular recognition site; other site 512565012694 dimerization interface [polypeptide binding]; other site 512565012695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012696 DNA binding residues [nucleotide binding] 512565012697 dimerization interface [polypeptide binding]; other site 512565012698 Histidine kinase; Region: HisKA_3; pfam07730 512565012699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012700 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 512565012701 Walker A/P-loop; other site 512565012702 ATP binding site [chemical binding]; other site 512565012703 Q-loop/lid; other site 512565012704 ABC transporter signature motif; other site 512565012705 Walker B; other site 512565012706 D-loop; other site 512565012707 H-loop/switch region; other site 512565012708 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 512565012709 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 512565012710 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 512565012711 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565012712 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565012713 DNA binding residues [nucleotide binding] 512565012714 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 512565012715 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 512565012716 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565012717 metal ion-dependent adhesion site (MIDAS); other site 512565012718 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565012719 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565012720 putative sugar binding sites [chemical binding]; other site 512565012721 Q-X-W motif; other site 512565012722 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565012723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565012724 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565012725 TM-ABC transporter signature motif; other site 512565012726 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 512565012727 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565012728 Walker A/P-loop; other site 512565012729 ATP binding site [chemical binding]; other site 512565012730 Q-loop/lid; other site 512565012731 ABC transporter signature motif; other site 512565012732 Walker B; other site 512565012733 D-loop; other site 512565012734 H-loop/switch region; other site 512565012735 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512565012736 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 512565012737 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 512565012738 putative ligand binding site [chemical binding]; other site 512565012739 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565012740 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565012741 nucleotide binding site [chemical binding]; other site 512565012742 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 512565012743 L-lactate permease; Region: Lactate_perm; cl00701 512565012744 L-lactate permease; Region: Lactate_perm; cl00701 512565012745 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 512565012746 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 512565012747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565012748 catalytic loop [active] 512565012749 iron binding site [ion binding]; other site 512565012750 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 512565012751 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 512565012752 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 512565012753 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565012754 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565012755 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 512565012756 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 512565012757 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 512565012758 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 512565012759 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 512565012760 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 512565012761 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565012762 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512565012763 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 512565012764 Walker A/P-loop; other site 512565012765 ATP binding site [chemical binding]; other site 512565012766 Q-loop/lid; other site 512565012767 ABC transporter signature motif; other site 512565012768 Walker B; other site 512565012769 D-loop; other site 512565012770 H-loop/switch region; other site 512565012771 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 512565012772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012773 Walker A/P-loop; other site 512565012774 ATP binding site [chemical binding]; other site 512565012775 Q-loop/lid; other site 512565012776 ABC transporter signature motif; other site 512565012777 Walker B; other site 512565012778 D-loop; other site 512565012779 H-loop/switch region; other site 512565012780 CHASE3 domain; Region: CHASE3; pfam05227 512565012781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 512565012782 dimerization interface [polypeptide binding]; other site 512565012783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565012784 dimer interface [polypeptide binding]; other site 512565012785 phosphorylation site [posttranslational modification] 512565012786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565012787 ATP binding site [chemical binding]; other site 512565012788 Mg2+ binding site [ion binding]; other site 512565012789 G-X-G motif; other site 512565012790 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 512565012791 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 512565012792 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565012793 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565012794 active site 512565012795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565012796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012797 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 512565012798 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565012799 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565012800 metal binding site [ion binding]; metal-binding site 512565012801 active site 512565012802 I-site; other site 512565012803 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 512565012804 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 512565012805 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 512565012806 homodimer interface [polypeptide binding]; other site 512565012807 substrate-cofactor binding pocket; other site 512565012808 catalytic residue [active] 512565012809 SnoaL-like domain; Region: SnoaL_2; pfam12680 512565012810 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 512565012811 Condensation domain; Region: Condensation; pfam00668 512565012812 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565012813 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565012814 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565012815 acyl-activating enzyme (AAE) consensus motif; other site 512565012816 AMP binding site [chemical binding]; other site 512565012817 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565012818 Condensation domain; Region: Condensation; pfam00668 512565012819 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565012820 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565012821 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565012822 acyl-activating enzyme (AAE) consensus motif; other site 512565012823 AMP binding site [chemical binding]; other site 512565012824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565012825 Condensation domain; Region: Condensation; pfam00668 512565012826 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565012827 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565012828 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565012829 acyl-activating enzyme (AAE) consensus motif; other site 512565012830 AMP binding site [chemical binding]; other site 512565012831 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565012832 Condensation domain; Region: Condensation; pfam00668 512565012833 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565012834 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565012835 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565012836 acyl-activating enzyme (AAE) consensus motif; other site 512565012837 AMP binding site [chemical binding]; other site 512565012838 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565012839 acyl-CoA synthetase; Validated; Region: PRK05850 512565012840 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 512565012841 acyl-activating enzyme (AAE) consensus motif; other site 512565012842 active site 512565012843 Phosphopantetheine attachment site; Region: PP-binding; cl09936 512565012844 Condensation domain; Region: Condensation; pfam00668 512565012845 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565012846 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 512565012847 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 512565012848 acyl-activating enzyme (AAE) consensus motif; other site 512565012849 AMP binding site [chemical binding]; other site 512565012850 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565012851 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565012852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012853 Walker A/P-loop; other site 512565012854 ATP binding site [chemical binding]; other site 512565012855 Q-loop/lid; other site 512565012856 ABC transporter signature motif; other site 512565012857 Walker B; other site 512565012858 D-loop; other site 512565012859 H-loop/switch region; other site 512565012860 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565012861 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565012862 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565012863 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 512565012864 Peptidase family M28; Region: Peptidase_M28; pfam04389 512565012865 metal binding site [ion binding]; metal-binding site 512565012866 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 512565012867 B12 binding site [chemical binding]; other site 512565012868 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 512565012869 MbtH-like protein; Region: MbtH; cl01279 512565012870 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 512565012871 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 512565012872 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 512565012873 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 512565012874 dimer interface [polypeptide binding]; other site 512565012875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565012876 catalytic residue [active] 512565012877 Condensation domain; Region: Condensation; pfam00668 512565012878 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 512565012879 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565012880 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565012881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 512565012882 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 512565012883 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 512565012884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565012885 short chain dehydrogenase; Provisional; Region: PRK12937 512565012886 NAD(P) binding site [chemical binding]; other site 512565012887 active site 512565012888 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565012889 sequence-specific DNA binding site [nucleotide binding]; other site 512565012890 salt bridge; other site 512565012891 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565012892 active site 512565012893 catalytic residues [active] 512565012894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565012895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012896 active site 512565012897 phosphorylation site [posttranslational modification] 512565012898 intermolecular recognition site; other site 512565012899 dimerization interface [polypeptide binding]; other site 512565012900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565012901 dimerization interface [polypeptide binding]; other site 512565012902 DNA binding residues [nucleotide binding] 512565012903 Histidine kinase; Region: HisKA_3; pfam07730 512565012904 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565012905 ATP binding site [chemical binding]; other site 512565012906 Mg2+ binding site [ion binding]; other site 512565012907 G-X-G motif; other site 512565012908 BCCT family transporter; Region: BCCT; pfam02028 512565012909 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 512565012910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565012911 Walker A motif; other site 512565012912 ATP binding site [chemical binding]; other site 512565012913 Walker B motif; other site 512565012914 arginine finger; other site 512565012915 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 512565012916 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 512565012917 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565012918 CBD_II domain; Region: CBD_II; smart00637 512565012919 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 512565012920 Phosphotransferase enzyme family; Region: APH; pfam01636 512565012921 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565012922 active site 512565012923 substrate binding site [chemical binding]; other site 512565012924 ATP binding site [chemical binding]; other site 512565012925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565012926 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565012927 NAD(P) binding site [chemical binding]; other site 512565012928 active site 512565012929 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565012930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012931 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 512565012932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565012933 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 512565012934 dimerization interface [polypeptide binding]; other site 512565012935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565012936 dimer interface [polypeptide binding]; other site 512565012937 phosphorylation site [posttranslational modification] 512565012938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565012939 ATP binding site [chemical binding]; other site 512565012940 Mg2+ binding site [ion binding]; other site 512565012941 G-X-G motif; other site 512565012942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565012943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565012944 active site 512565012945 phosphorylation site [posttranslational modification] 512565012946 intermolecular recognition site; other site 512565012947 dimerization interface [polypeptide binding]; other site 512565012948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565012949 DNA binding site [nucleotide binding] 512565012950 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 512565012951 putative active site [active] 512565012952 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 512565012953 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 512565012954 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 512565012955 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 512565012956 active site 512565012957 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 512565012958 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 512565012959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565012960 ATP binding site [chemical binding]; other site 512565012961 Walker B motif; other site 512565012962 arginine finger; other site 512565012963 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 512565012964 NlpC/P60 family; Region: NLPC_P60; pfam00877 512565012965 Penicillinase repressor; Region: Pencillinase_R; pfam03965 512565012966 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 512565012967 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 512565012968 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 512565012969 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 512565012970 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565012971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012972 Walker A/P-loop; other site 512565012973 ATP binding site [chemical binding]; other site 512565012974 Q-loop/lid; other site 512565012975 ABC transporter signature motif; other site 512565012976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 512565012977 Walker B; other site 512565012978 D-loop; other site 512565012979 H-loop/switch region; other site 512565012980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565012981 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512565012982 Walker A/P-loop; other site 512565012983 ATP binding site [chemical binding]; other site 512565012984 ABC transporter signature motif; other site 512565012985 Walker B; other site 512565012986 D-loop; other site 512565012987 H-loop/switch region; other site 512565012988 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 512565012989 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565012990 dimer interface [polypeptide binding]; other site 512565012991 active site 512565012992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565012993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565012994 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 512565012995 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 512565012996 active site 512565012997 DNA binding site [nucleotide binding] 512565012998 Int/Topo IB signature motif; other site 512565012999 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 512565013000 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 512565013001 putative active site [active] 512565013002 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 512565013003 classical (c) SDRs; Region: SDR_c; cd05233 512565013004 NAD(P) binding site [chemical binding]; other site 512565013005 active site 512565013006 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 512565013007 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565013008 substrate binding site [chemical binding]; other site 512565013009 ATP binding site [chemical binding]; other site 512565013010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565013011 active site 512565013012 HIGH motif; other site 512565013013 nucleotide binding site [chemical binding]; other site 512565013014 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 512565013015 dimer interface [polypeptide binding]; other site 512565013016 active site 512565013017 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 512565013018 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 512565013019 putative ADP-binding pocket [chemical binding]; other site 512565013020 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565013021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565013022 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 512565013023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565013024 active site 512565013025 motif I; other site 512565013026 motif II; other site 512565013027 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 512565013028 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 512565013029 putative active site [active] 512565013030 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512565013031 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 512565013032 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 512565013033 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565013034 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 512565013035 NAD(P) binding site [chemical binding]; other site 512565013036 catalytic residues [active] 512565013037 Domain of unknown function (DUF222); Region: DUF222; pfam02720 512565013038 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 512565013039 active site 512565013040 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565013041 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 512565013042 Probable Catalytic site; other site 512565013043 metal-binding site 512565013044 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 512565013045 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565013046 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565013047 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 512565013048 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 512565013049 dihydropteroate synthase; Region: DHPS; TIGR01496 512565013050 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 512565013051 substrate binding pocket [chemical binding]; other site 512565013052 dimer interface [polypeptide binding]; other site 512565013053 inhibitor binding site; inhibition site 512565013054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565013055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565013056 D-galactonate transporter; Region: 2A0114; TIGR00893 512565013057 putative substrate translocation pore; other site 512565013058 PQQ-like domain; Region: PQQ_2; pfam13360 512565013059 Laminin G domain; Region: Laminin_G_2; pfam02210 512565013060 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 512565013061 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565013062 Domain of unknown function (DUF385); Region: DUF385; cl04387 512565013063 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 512565013064 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 512565013065 active site 512565013066 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565013067 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565013068 substrate binding site [chemical binding]; other site 512565013069 oxyanion hole (OAH) forming residues; other site 512565013070 trimer interface [polypeptide binding]; other site 512565013071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565013072 substrate binding site [chemical binding]; other site 512565013073 trimer interface [polypeptide binding]; other site 512565013074 oxyanion hole (OAH) forming residues; other site 512565013075 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 512565013076 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 512565013077 dimer interface [polypeptide binding]; other site 512565013078 active site 512565013079 acyl carrier protein; Validated; Region: PRK07117 512565013080 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 512565013081 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 512565013082 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 512565013083 active site 512565013084 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 512565013085 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 512565013086 dimer interface [polypeptide binding]; other site 512565013087 active site 512565013088 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565013089 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 512565013090 dimer interface [polypeptide binding]; other site 512565013091 active site 512565013092 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 512565013093 classical (c) SDRs; Region: SDR_c; cd05233 512565013094 NAD(P) binding site [chemical binding]; other site 512565013095 active site 512565013096 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 512565013097 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565013098 Hemerythrin-like domain; Region: Hr-like; cd12108 512565013099 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565013100 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565013101 active site 512565013102 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565013103 DNA binding site [nucleotide binding] 512565013104 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565013105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565013106 SnoaL-like domain; Region: SnoaL_4; pfam13577 512565013107 Domain of unknown function (DUF385); Region: DUF385; pfam04075 512565013108 Hemerythrin-like domain; Region: Hr-like; cd12108 512565013109 Fe binding site [ion binding]; other site 512565013110 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512565013111 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 512565013112 Cytochrome P450; Region: p450; cl12078 512565013113 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 512565013114 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 512565013115 homodimer interface [polypeptide binding]; other site 512565013116 active site 512565013117 TDP-binding site; other site 512565013118 acceptor substrate-binding pocket; other site 512565013119 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565013120 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565013121 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 512565013122 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 512565013123 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 512565013124 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 512565013125 inhibitor-cofactor binding pocket; inhibition site 512565013126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565013127 catalytic residue [active] 512565013128 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565013129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565013130 S-adenosylmethionine binding site [chemical binding]; other site 512565013131 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 512565013132 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 512565013133 extended (e) SDRs; Region: SDR_e; cd08946 512565013134 NAD(P) binding site [chemical binding]; other site 512565013135 active site 512565013136 substrate binding site [chemical binding]; other site 512565013137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565013138 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565013139 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565013140 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 512565013141 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 512565013142 dimer interface [polypeptide binding]; other site 512565013143 active site 512565013144 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 512565013145 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 512565013146 active site 512565013147 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 512565013148 putative hydrophobic ligand binding site [chemical binding]; other site 512565013149 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 512565013150 putative hydrophobic ligand binding site [chemical binding]; other site 512565013151 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565013152 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565013153 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565013154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565013155 NAD(P) binding site [chemical binding]; other site 512565013156 active site 512565013157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565013158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565013159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565013160 Walker A/P-loop; other site 512565013161 ATP binding site [chemical binding]; other site 512565013162 Q-loop/lid; other site 512565013163 ABC transporter signature motif; other site 512565013164 Walker B; other site 512565013165 D-loop; other site 512565013166 H-loop/switch region; other site 512565013167 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 512565013168 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 512565013169 NAD binding site [chemical binding]; other site 512565013170 substrate binding site [chemical binding]; other site 512565013171 homodimer interface [polypeptide binding]; other site 512565013172 active site 512565013173 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 512565013174 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 512565013175 substrate binding site; other site 512565013176 tetramer interface; other site 512565013177 Predicted flavoprotein [General function prediction only]; Region: COG0431 512565013178 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565013179 fructuronate transporter; Provisional; Region: PRK10034; cl15264 512565013180 GntP family permease; Region: GntP_permease; pfam02447 512565013181 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565013182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565013183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565013184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565013185 putative substrate translocation pore; other site 512565013186 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565013187 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565013188 substrate binding site [chemical binding]; other site 512565013189 ATP binding site [chemical binding]; other site 512565013190 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 512565013191 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512565013192 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 512565013193 heat shock protein 90; Provisional; Region: PRK05218 512565013194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013195 ATP binding site [chemical binding]; other site 512565013196 Mg2+ binding site [ion binding]; other site 512565013197 G-X-G motif; other site 512565013198 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565013199 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565013200 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565013201 putative catalytic site [active] 512565013202 putative metal binding site [ion binding]; other site 512565013203 putative phosphate binding site [ion binding]; other site 512565013204 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 512565013205 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 512565013206 cobalamin binding residues [chemical binding]; other site 512565013207 putative BtuC binding residues; other site 512565013208 dimer interface [polypeptide binding]; other site 512565013209 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 512565013210 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565013211 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 512565013212 putative NAD(P) binding site [chemical binding]; other site 512565013213 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 512565013214 active site 512565013215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565013216 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565013217 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565013218 Methyltransferase domain; Region: Methyltransf_18; pfam12847 512565013219 RibD C-terminal domain; Region: RibD_C; cl17279 512565013220 RibD C-terminal domain; Region: RibD_C; cl17279 512565013221 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 512565013222 dimerization interface [polypeptide binding]; other site 512565013223 active site 512565013224 PAS fold; Region: PAS_4; pfam08448 512565013225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565013226 putative active site [active] 512565013227 heme pocket [chemical binding]; other site 512565013228 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565013229 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565013230 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565013231 ATP binding site [chemical binding]; other site 512565013232 Mg2+ binding site [ion binding]; other site 512565013233 G-X-G motif; other site 512565013234 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565013235 anti sigma factor interaction site; other site 512565013236 regulatory phosphorylation site [posttranslational modification]; other site 512565013237 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 512565013238 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565013239 ATP binding site [chemical binding]; other site 512565013240 putative Mg++ binding site [ion binding]; other site 512565013241 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565013242 nucleotide binding region [chemical binding]; other site 512565013243 ATP-binding site [chemical binding]; other site 512565013244 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 512565013245 HRDC domain; Region: HRDC; pfam00570 512565013246 YceI-like domain; Region: YceI; smart00867 512565013247 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 512565013248 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565013249 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 512565013250 dimer interface [polypeptide binding]; other site 512565013251 pyruvate phosphate dikinase; Provisional; Region: PRK09279 512565013252 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 512565013253 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 512565013254 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 512565013255 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 512565013256 FAD binding domain; Region: FAD_binding_4; pfam01565 512565013257 FAD binding domain; Region: FAD_binding_4; pfam01565 512565013258 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565013259 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 512565013260 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 512565013261 Cysteine-rich domain; Region: CCG; pfam02754 512565013262 Cysteine-rich domain; Region: CCG; pfam02754 512565013263 Cellulose binding domain; Region: CBM_2; pfam00553 512565013264 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 512565013265 active site 512565013266 catalytic triad [active] 512565013267 oxyanion hole [active] 512565013268 Uncharacterized conserved protein [Function unknown]; Region: COG1359 512565013269 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 512565013270 SmpB-tmRNA interface; other site 512565013271 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512565013272 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 512565013273 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 512565013274 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 512565013275 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 512565013276 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 512565013277 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 512565013278 putative ligand binding site [chemical binding]; other site 512565013279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565013280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013281 dimer interface [polypeptide binding]; other site 512565013282 conserved gate region; other site 512565013283 putative PBP binding loops; other site 512565013284 ABC-ATPase subunit interface; other site 512565013285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013286 ABC-ATPase subunit interface; other site 512565013287 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565013288 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565013289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512565013290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565013291 Coenzyme A binding pocket [chemical binding]; other site 512565013292 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565013293 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 512565013294 tetramerization interface [polypeptide binding]; other site 512565013295 NAD(P) binding site [chemical binding]; other site 512565013296 catalytic residues [active] 512565013297 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 512565013298 active site 512565013299 catalytic site [active] 512565013300 GLTT repeat (6 copies); Region: GLTT; pfam01744 512565013301 Domain of unknown function (DUF222); Region: DUF222; pfam02720 512565013302 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 512565013303 active site 512565013304 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 512565013305 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512565013306 active site 512565013307 catalytic triad [active] 512565013308 oxyanion hole [active] 512565013309 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565013310 Cellulose binding domain; Region: CBM_2; pfam00553 512565013311 Cellulose binding domain; Region: CBM_2; pfam00553 512565013312 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 512565013313 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 512565013314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565013315 NAD(P) binding site [chemical binding]; other site 512565013316 active site 512565013317 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 512565013318 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 512565013319 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565013320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013321 dimer interface [polypeptide binding]; other site 512565013322 conserved gate region; other site 512565013323 putative PBP binding loops; other site 512565013324 ABC-ATPase subunit interface; other site 512565013325 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565013326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013327 dimer interface [polypeptide binding]; other site 512565013328 conserved gate region; other site 512565013329 putative PBP binding loops; other site 512565013330 ABC-ATPase subunit interface; other site 512565013331 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565013332 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565013333 Walker A/P-loop; other site 512565013334 ATP binding site [chemical binding]; other site 512565013335 Q-loop/lid; other site 512565013336 ABC transporter signature motif; other site 512565013337 Walker B; other site 512565013338 D-loop; other site 512565013339 H-loop/switch region; other site 512565013340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565013341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565013342 Walker A/P-loop; other site 512565013343 ATP binding site [chemical binding]; other site 512565013344 Q-loop/lid; other site 512565013345 ABC transporter signature motif; other site 512565013346 Walker B; other site 512565013347 D-loop; other site 512565013348 H-loop/switch region; other site 512565013349 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 512565013350 active site 512565013351 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 512565013352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565013353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565013354 dimerization interface [polypeptide binding]; other site 512565013355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565013356 dimer interface [polypeptide binding]; other site 512565013357 phosphorylation site [posttranslational modification] 512565013358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013359 Mg2+ binding site [ion binding]; other site 512565013360 G-X-G motif; other site 512565013361 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565013362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013363 active site 512565013364 phosphorylation site [posttranslational modification] 512565013365 intermolecular recognition site; other site 512565013366 dimerization interface [polypeptide binding]; other site 512565013367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565013368 DNA binding site [nucleotide binding] 512565013369 Amino acid permease; Region: AA_permease_2; pfam13520 512565013370 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565013371 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565013372 active site 512565013373 ATP binding site [chemical binding]; other site 512565013374 substrate binding site [chemical binding]; other site 512565013375 activation loop (A-loop); other site 512565013376 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 512565013377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565013378 dimerization interface [polypeptide binding]; other site 512565013379 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565013380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565013381 dimer interface [polypeptide binding]; other site 512565013382 putative CheW interface [polypeptide binding]; other site 512565013383 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565013384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565013385 DNA binding residues [nucleotide binding] 512565013386 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565013387 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 512565013388 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 512565013389 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 512565013390 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 512565013391 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 512565013392 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 512565013393 putative sugar binding sites [chemical binding]; other site 512565013394 Q-X-W motif; other site 512565013395 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565013396 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 512565013397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013398 ABC-ATPase subunit interface; other site 512565013399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013400 dimer interface [polypeptide binding]; other site 512565013401 conserved gate region; other site 512565013402 putative PBP binding loops; other site 512565013403 ABC-ATPase subunit interface; other site 512565013404 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 512565013405 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 512565013406 Walker A/P-loop; other site 512565013407 ATP binding site [chemical binding]; other site 512565013408 Q-loop/lid; other site 512565013409 ABC transporter signature motif; other site 512565013410 Walker B; other site 512565013411 D-loop; other site 512565013412 H-loop/switch region; other site 512565013413 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 512565013414 active sites [active] 512565013415 tetramer interface [polypeptide binding]; other site 512565013416 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 512565013417 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565013418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565013419 DNA binding site [nucleotide binding] 512565013420 domain linker motif; other site 512565013421 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565013422 dimerization interface [polypeptide binding]; other site 512565013423 ligand binding site [chemical binding]; other site 512565013424 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 512565013425 active sites [active] 512565013426 tetramer interface [polypeptide binding]; other site 512565013427 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512565013428 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512565013429 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512565013430 putative active site [active] 512565013431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565013432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565013433 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565013434 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 512565013435 FAD dependent oxidoreductase; Region: DAO; pfam01266 512565013436 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 512565013437 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 512565013438 ATP binding site [chemical binding]; other site 512565013439 substrate interface [chemical binding]; other site 512565013440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565013441 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 512565013442 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 512565013443 NAD binding site [chemical binding]; other site 512565013444 catalytic Zn binding site [ion binding]; other site 512565013445 substrate binding site [chemical binding]; other site 512565013446 structural Zn binding site [ion binding]; other site 512565013447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565013448 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 512565013449 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 512565013450 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 512565013451 putative active site [active] 512565013452 putative substrate binding site [chemical binding]; other site 512565013453 putative cosubstrate binding site; other site 512565013454 catalytic site [active] 512565013455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565013456 dimerization interface [polypeptide binding]; other site 512565013457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565013458 dimer interface [polypeptide binding]; other site 512565013459 phosphorylation site [posttranslational modification] 512565013460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013461 ATP binding site [chemical binding]; other site 512565013462 Mg2+ binding site [ion binding]; other site 512565013463 G-X-G motif; other site 512565013464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565013465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013466 active site 512565013467 phosphorylation site [posttranslational modification] 512565013468 intermolecular recognition site; other site 512565013469 dimerization interface [polypeptide binding]; other site 512565013470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565013471 DNA binding site [nucleotide binding] 512565013472 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 512565013473 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 512565013474 dimer interface [polypeptide binding]; other site 512565013475 active site 512565013476 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 512565013477 Ligand Binding Site [chemical binding]; other site 512565013478 Molecular Tunnel; other site 512565013479 VanZ like family; Region: VanZ; cl01971 512565013480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565013481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013482 active site 512565013483 phosphorylation site [posttranslational modification] 512565013484 intermolecular recognition site; other site 512565013485 dimerization interface [polypeptide binding]; other site 512565013486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565013487 DNA binding site [nucleotide binding] 512565013488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565013489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565013490 dimerization interface [polypeptide binding]; other site 512565013491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565013492 dimer interface [polypeptide binding]; other site 512565013493 phosphorylation site [posttranslational modification] 512565013494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013495 ATP binding site [chemical binding]; other site 512565013496 Mg2+ binding site [ion binding]; other site 512565013497 G-X-G motif; other site 512565013498 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 512565013499 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 512565013500 RNA polymerase factor sigma-70; Validated; Region: PRK08241 512565013501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565013502 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565013503 DNA binding residues [nucleotide binding] 512565013504 SnoaL-like domain; Region: SnoaL_2; pfam12680 512565013505 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565013506 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 512565013507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565013508 Walker A/P-loop; other site 512565013509 ATP binding site [chemical binding]; other site 512565013510 Q-loop/lid; other site 512565013511 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 512565013512 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512565013513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565013514 Walker A/P-loop; other site 512565013515 ATP binding site [chemical binding]; other site 512565013516 Q-loop/lid; other site 512565013517 ABC transporter signature motif; other site 512565013518 Walker B; other site 512565013519 D-loop; other site 512565013520 H-loop/switch region; other site 512565013521 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565013522 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565013523 DNA binding residues [nucleotide binding] 512565013524 Bifunctional nuclease; Region: DNase-RNase; pfam02577 512565013525 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 512565013526 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565013527 DNA binding residues [nucleotide binding] 512565013528 dimer interface [polypeptide binding]; other site 512565013529 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 512565013530 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 512565013531 phosphopeptide binding site; other site 512565013532 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 512565013533 lipoyl attachment site [posttranslational modification]; other site 512565013534 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 512565013535 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 512565013536 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 512565013537 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 512565013538 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565013539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565013540 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 512565013541 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 512565013542 metal ion-dependent adhesion site (MIDAS); other site 512565013543 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 512565013544 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 512565013545 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 512565013546 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512565013547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565013548 Walker A/P-loop; other site 512565013549 ATP binding site [chemical binding]; other site 512565013550 Q-loop/lid; other site 512565013551 ABC transporter signature motif; other site 512565013552 Walker B; other site 512565013553 D-loop; other site 512565013554 H-loop/switch region; other site 512565013555 ABC transporter; Region: ABC_tran_2; pfam12848 512565013556 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565013557 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 512565013558 PKC phosphorylation site [posttranslational modification]; other site 512565013559 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565013560 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 512565013561 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 512565013562 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565013563 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 512565013564 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 512565013565 ligand binding site; other site 512565013566 oligomer interface; other site 512565013567 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 512565013568 dimer interface [polypeptide binding]; other site 512565013569 N-terminal domain interface [polypeptide binding]; other site 512565013570 sulfate 1 binding site; other site 512565013571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565013572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565013573 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 512565013574 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565013575 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 512565013576 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 512565013577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512565013578 RNA binding surface [nucleotide binding]; other site 512565013579 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 512565013580 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 512565013581 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 512565013582 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 512565013583 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 512565013584 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565013585 anti sigma factor interaction site; other site 512565013586 regulatory phosphorylation site [posttranslational modification]; other site 512565013587 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565013588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565013589 nucleotide binding site [chemical binding]; other site 512565013590 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 512565013591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 512565013592 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565013593 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565013594 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565013595 TM-ABC transporter signature motif; other site 512565013596 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 512565013597 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565013598 Walker A/P-loop; other site 512565013599 ATP binding site [chemical binding]; other site 512565013600 Q-loop/lid; other site 512565013601 ABC transporter signature motif; other site 512565013602 Walker B; other site 512565013603 D-loop; other site 512565013604 H-loop/switch region; other site 512565013605 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512565013606 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 512565013607 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 512565013608 putative ligand binding site [chemical binding]; other site 512565013609 L-arabinose isomerase; Provisional; Region: PRK02929 512565013610 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 512565013611 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 512565013612 trimer interface [polypeptide binding]; other site 512565013613 putative substrate binding site [chemical binding]; other site 512565013614 putative metal binding site [ion binding]; other site 512565013615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565013616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565013617 DNA binding site [nucleotide binding] 512565013618 domain linker motif; other site 512565013619 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 512565013620 ligand binding site [chemical binding]; other site 512565013621 dimerization interface (open form) [polypeptide binding]; other site 512565013622 dimerization interface (closed form) [polypeptide binding]; other site 512565013623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 512565013624 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 512565013625 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 512565013626 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 512565013627 active site 512565013628 Pirin-related protein [General function prediction only]; Region: COG1741 512565013629 Pirin; Region: Pirin; pfam02678 512565013630 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 512565013631 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 512565013632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565013633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565013634 binding surface 512565013635 TPR motif; other site 512565013636 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565013637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565013638 metal binding site [ion binding]; metal-binding site 512565013639 active site 512565013640 I-site; other site 512565013641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565013642 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565013643 FtsX-like permease family; Region: FtsX; pfam02687 512565013644 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565013645 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565013646 Walker A/P-loop; other site 512565013647 ATP binding site [chemical binding]; other site 512565013648 Q-loop/lid; other site 512565013649 ABC transporter signature motif; other site 512565013650 Walker B; other site 512565013651 D-loop; other site 512565013652 H-loop/switch region; other site 512565013653 HlyD family secretion protein; Region: HlyD_3; pfam13437 512565013654 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 512565013655 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 512565013656 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 512565013657 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 512565013658 Acyltransferase family; Region: Acyl_transf_3; pfam01757 512565013659 CheW-like domain; Region: CheW; pfam01584 512565013660 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 512565013661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565013662 S-adenosylmethionine binding site [chemical binding]; other site 512565013663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 512565013664 TPR motif; other site 512565013665 binding surface 512565013666 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 512565013667 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565013668 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565013669 dimer interface [polypeptide binding]; other site 512565013670 putative CheW interface [polypeptide binding]; other site 512565013671 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 512565013672 putative binding surface; other site 512565013673 active site 512565013674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013675 ATP binding site [chemical binding]; other site 512565013676 Mg2+ binding site [ion binding]; other site 512565013677 G-X-G motif; other site 512565013678 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 512565013679 Response regulator receiver domain; Region: Response_reg; pfam00072 512565013680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013681 active site 512565013682 phosphorylation site [posttranslational modification] 512565013683 intermolecular recognition site; other site 512565013684 dimerization interface [polypeptide binding]; other site 512565013685 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 512565013686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013687 active site 512565013688 phosphorylation site [posttranslational modification] 512565013689 intermolecular recognition site; other site 512565013690 dimerization interface [polypeptide binding]; other site 512565013691 CheB methylesterase; Region: CheB_methylest; pfam01339 512565013692 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565013693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013694 active site 512565013695 phosphorylation site [posttranslational modification] 512565013696 intermolecular recognition site; other site 512565013697 dimerization interface [polypeptide binding]; other site 512565013698 Response regulator receiver domain; Region: Response_reg; pfam00072 512565013699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013700 active site 512565013701 phosphorylation site [posttranslational modification] 512565013702 intermolecular recognition site; other site 512565013703 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565013704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013705 intermolecular recognition site; other site 512565013706 active site 512565013707 dimerization interface [polypeptide binding]; other site 512565013708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565013709 dimer interface [polypeptide binding]; other site 512565013710 phosphorylation site [posttranslational modification] 512565013711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013712 ATP binding site [chemical binding]; other site 512565013713 Mg2+ binding site [ion binding]; other site 512565013714 G-X-G motif; other site 512565013715 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 512565013716 amidase catalytic site [active] 512565013717 Zn binding residues [ion binding]; other site 512565013718 substrate binding site [chemical binding]; other site 512565013719 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565013720 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565013721 FtsX-like permease family; Region: FtsX; pfam02687 512565013722 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565013723 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565013724 Walker A/P-loop; other site 512565013725 ATP binding site [chemical binding]; other site 512565013726 Q-loop/lid; other site 512565013727 ABC transporter signature motif; other site 512565013728 Walker B; other site 512565013729 D-loop; other site 512565013730 H-loop/switch region; other site 512565013731 Histidine kinase; Region: HisKA_3; pfam07730 512565013732 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565013733 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565013734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013735 active site 512565013736 phosphorylation site [posttranslational modification] 512565013737 intermolecular recognition site; other site 512565013738 dimerization interface [polypeptide binding]; other site 512565013739 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565013740 DNA binding residues [nucleotide binding] 512565013741 dimerization interface [polypeptide binding]; other site 512565013742 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 512565013743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565013744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565013745 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 512565013746 putative dimerization interface [polypeptide binding]; other site 512565013747 Predicted acetyltransferase [General function prediction only]; Region: COG3981 512565013748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565013749 Domain of unknown function (DUF305); Region: DUF305; pfam03713 512565013750 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565013751 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 512565013752 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565013753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565013754 non-specific DNA binding site [nucleotide binding]; other site 512565013755 salt bridge; other site 512565013756 sequence-specific DNA binding site [nucleotide binding]; other site 512565013757 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 512565013758 Domain of unknown function (DUF955); Region: DUF955; pfam06114 512565013759 isocitrate lyase; Provisional; Region: PRK15063 512565013760 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 512565013761 tetramer interface [polypeptide binding]; other site 512565013762 active site 512565013763 Mg2+/Mn2+ binding site [ion binding]; other site 512565013764 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 512565013765 malate synthase A; Region: malate_syn_A; TIGR01344 512565013766 active site 512565013767 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 512565013768 aromatic arch; other site 512565013769 DCoH dimer interaction site [polypeptide binding]; other site 512565013770 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 512565013771 DCoH tetramer interaction site [polypeptide binding]; other site 512565013772 substrate binding site [chemical binding]; other site 512565013773 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565013774 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 512565013775 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 512565013776 Sulfatase; Region: Sulfatase; pfam00884 512565013777 Protein of unknown function (DUF402); Region: DUF402; pfam04167 512565013778 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512565013779 homotrimer interaction site [polypeptide binding]; other site 512565013780 putative active site [active] 512565013781 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 512565013782 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 512565013783 active site 512565013784 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 512565013785 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 512565013786 active site 512565013787 CHASE4 domain; Region: CHASE4; cl01308 512565013788 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565013789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565013790 dimer interface [polypeptide binding]; other site 512565013791 putative CheW interface [polypeptide binding]; other site 512565013792 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565013793 activation loop (A-loop); other site 512565013794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565013795 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565013796 Walker A motif; other site 512565013797 ATP binding site [chemical binding]; other site 512565013798 Walker B motif; other site 512565013799 arginine finger; other site 512565013800 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565013801 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 512565013802 PA/protease or protease-like domain interface [polypeptide binding]; other site 512565013803 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 512565013804 Peptidase family M28; Region: Peptidase_M28; pfam04389 512565013805 active site 512565013806 metal binding site [ion binding]; metal-binding site 512565013807 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565013808 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 512565013809 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565013810 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 512565013811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565013812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565013813 dimer interface [polypeptide binding]; other site 512565013814 conserved gate region; other site 512565013815 putative PBP binding loops; other site 512565013816 ABC-ATPase subunit interface; other site 512565013817 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512565013818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565013819 Walker A/P-loop; other site 512565013820 ATP binding site [chemical binding]; other site 512565013821 Q-loop/lid; other site 512565013822 ABC transporter signature motif; other site 512565013823 Walker B; other site 512565013824 D-loop; other site 512565013825 H-loop/switch region; other site 512565013826 TOBE domain; Region: TOBE_2; pfam08402 512565013827 Cellulose binding domain; Region: CBM_2; pfam00553 512565013828 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565013829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 512565013830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565013831 ATP binding site [chemical binding]; other site 512565013832 G-X-G motif; other site 512565013833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565013834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013835 active site 512565013836 phosphorylation site [posttranslational modification] 512565013837 intermolecular recognition site; other site 512565013838 dimerization interface [polypeptide binding]; other site 512565013839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565013840 DNA binding residues [nucleotide binding] 512565013841 dimerization interface [polypeptide binding]; other site 512565013842 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565013843 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565013844 Walker A/P-loop; other site 512565013845 ATP binding site [chemical binding]; other site 512565013846 Q-loop/lid; other site 512565013847 ABC transporter signature motif; other site 512565013848 Walker B; other site 512565013849 D-loop; other site 512565013850 H-loop/switch region; other site 512565013851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565013852 ABC-ATPase subunit interface; other site 512565013853 dimer interface [polypeptide binding]; other site 512565013854 putative PBP binding regions; other site 512565013855 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565013856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565013857 ABC-ATPase subunit interface; other site 512565013858 dimer interface [polypeptide binding]; other site 512565013859 putative PBP binding regions; other site 512565013860 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 512565013861 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 512565013862 siderophore binding site; other site 512565013863 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 512565013864 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 512565013865 intersubunit interface [polypeptide binding]; other site 512565013866 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565013867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565013868 ABC-ATPase subunit interface; other site 512565013869 dimer interface [polypeptide binding]; other site 512565013870 putative PBP binding regions; other site 512565013871 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 512565013872 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565013873 ABC-ATPase subunit interface; other site 512565013874 dimer interface [polypeptide binding]; other site 512565013875 putative PBP binding regions; other site 512565013876 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565013877 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565013878 Walker A/P-loop; other site 512565013879 ATP binding site [chemical binding]; other site 512565013880 Q-loop/lid; other site 512565013881 ABC transporter signature motif; other site 512565013882 Walker B; other site 512565013883 D-loop; other site 512565013884 H-loop/switch region; other site 512565013885 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565013886 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565013887 dimerization interface [polypeptide binding]; other site 512565013888 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565013889 putative CheW interface [polypeptide binding]; other site 512565013890 Predicted dehydrogenase [General function prediction only]; Region: COG0579 512565013891 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565013892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565013893 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 512565013894 dimerization interface [polypeptide binding]; other site 512565013895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565013896 dimer interface [polypeptide binding]; other site 512565013897 phosphorylation site [posttranslational modification] 512565013898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565013899 ATP binding site [chemical binding]; other site 512565013900 Mg2+ binding site [ion binding]; other site 512565013901 G-X-G motif; other site 512565013902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565013903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013904 active site 512565013905 phosphorylation site [posttranslational modification] 512565013906 intermolecular recognition site; other site 512565013907 dimerization interface [polypeptide binding]; other site 512565013908 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565013909 DNA binding site [nucleotide binding] 512565013910 FMN-binding domain; Region: FMN_bind; cl01081 512565013911 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 512565013912 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 512565013913 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 512565013914 FAD binding pocket [chemical binding]; other site 512565013915 FAD binding motif [chemical binding]; other site 512565013916 phosphate binding motif [ion binding]; other site 512565013917 beta-alpha-beta structure motif; other site 512565013918 NAD binding pocket [chemical binding]; other site 512565013919 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 512565013920 putative metal binding residues [ion binding]; other site 512565013921 signature motif; other site 512565013922 dimer interface [polypeptide binding]; other site 512565013923 active site 512565013924 polyP binding site; other site 512565013925 substrate binding site [chemical binding]; other site 512565013926 acceptor-phosphate pocket; other site 512565013927 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 512565013928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565013929 non-specific DNA binding site [nucleotide binding]; other site 512565013930 salt bridge; other site 512565013931 sequence-specific DNA binding site [nucleotide binding]; other site 512565013932 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 512565013933 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 512565013934 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565013935 Ligand binding site; other site 512565013936 Putative Catalytic site; other site 512565013937 DXD motif; other site 512565013938 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 512565013939 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565013940 Walker A motif; other site 512565013941 ATP binding site [chemical binding]; other site 512565013942 Walker B motif; other site 512565013943 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565013944 Walker A motif; other site 512565013945 ATP binding site [chemical binding]; other site 512565013946 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 512565013947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565013948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565013949 metal binding site [ion binding]; metal-binding site 512565013950 active site 512565013951 I-site; other site 512565013952 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565013953 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565013954 AAA ATPase domain; Region: AAA_16; pfam13191 512565013955 Predicted ATPase [General function prediction only]; Region: COG3903 512565013956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565013957 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 512565013958 Walker A/P-loop; other site 512565013959 ATP binding site [chemical binding]; other site 512565013960 Q-loop/lid; other site 512565013961 ABC transporter signature motif; other site 512565013962 Walker B; other site 512565013963 D-loop; other site 512565013964 H-loop/switch region; other site 512565013965 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565013966 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565013967 Uncharacterized conserved protein [Function unknown]; Region: COG3342 512565013968 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 512565013969 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 512565013970 FtsX-like permease family; Region: FtsX; pfam02687 512565013971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565013972 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565013973 Walker A/P-loop; other site 512565013974 ATP binding site [chemical binding]; other site 512565013975 Q-loop/lid; other site 512565013976 ABC transporter signature motif; other site 512565013977 Walker B; other site 512565013978 D-loop; other site 512565013979 H-loop/switch region; other site 512565013980 Putative sensor; Region: Sensor; pfam13796 512565013981 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565013982 Histidine kinase; Region: HisKA_3; pfam07730 512565013983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565013984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565013985 active site 512565013986 phosphorylation site [posttranslational modification] 512565013987 intermolecular recognition site; other site 512565013988 dimerization interface [polypeptide binding]; other site 512565013989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565013990 DNA binding residues [nucleotide binding] 512565013991 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 512565013992 active site 512565013993 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 512565013994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565013995 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 512565013996 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 512565013997 acyl-activating enzyme (AAE) consensus motif; other site 512565013998 putative AMP binding site [chemical binding]; other site 512565013999 putative active site [active] 512565014000 putative CoA binding site [chemical binding]; other site 512565014001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565014002 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512565014003 substrate binding pocket [chemical binding]; other site 512565014004 membrane-bound complex binding site; other site 512565014005 hinge residues; other site 512565014006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565014007 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565014008 active site 512565014009 ATP binding site [chemical binding]; other site 512565014010 substrate binding site [chemical binding]; other site 512565014011 activation loop (A-loop); other site 512565014012 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 512565014013 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565014014 metal ion-dependent adhesion site (MIDAS); other site 512565014015 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 512565014016 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 512565014017 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 512565014018 phosphopeptide binding site; other site 512565014019 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565014020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565014021 non-specific DNA binding site [nucleotide binding]; other site 512565014022 salt bridge; other site 512565014023 sequence-specific DNA binding site [nucleotide binding]; other site 512565014024 AAA ATPase domain; Region: AAA_16; pfam13191 512565014025 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565014026 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565014027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565014028 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565014029 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565014030 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 512565014031 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 512565014032 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 512565014033 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512565014034 active site 512565014035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565014036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565014037 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 512565014038 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 512565014039 acyl-activating enzyme (AAE) consensus motif; other site 512565014040 putative AMP binding site [chemical binding]; other site 512565014041 putative active site [active] 512565014042 putative CoA binding site [chemical binding]; other site 512565014043 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565014044 active site 512565014045 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565014046 anti sigma factor interaction site; other site 512565014047 regulatory phosphorylation site [posttranslational modification]; other site 512565014048 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565014049 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565014050 ATP binding site [chemical binding]; other site 512565014051 Mg2+ binding site [ion binding]; other site 512565014052 G-X-G motif; other site 512565014053 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 512565014054 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565014055 ATP binding site [chemical binding]; other site 512565014056 putative Mg++ binding site [ion binding]; other site 512565014057 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565014058 nucleotide binding region [chemical binding]; other site 512565014059 ATP-binding site [chemical binding]; other site 512565014060 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 512565014061 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 512565014062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565014063 motif II; other site 512565014064 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 512565014065 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 512565014066 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 512565014067 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 512565014068 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 512565014069 Predicted transcriptional regulator [Transcription]; Region: COG2378 512565014070 WYL domain; Region: WYL; pfam13280 512565014071 Predicted transcriptional regulator [Transcription]; Region: COG2378 512565014072 WYL domain; Region: WYL; pfam13280 512565014073 Cation efflux family; Region: Cation_efflux; pfam01545 512565014074 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 512565014075 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 512565014076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565014077 S-adenosylmethionine binding site [chemical binding]; other site 512565014078 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 512565014079 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 512565014080 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 512565014081 active site 512565014082 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 512565014083 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 512565014084 active site 512565014085 Pup-like protein; Region: Pup; pfam05639 512565014086 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 512565014087 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512565014088 proteasome ATPase; Region: pup_AAA; TIGR03689 512565014089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565014090 Walker A motif; other site 512565014091 ATP binding site [chemical binding]; other site 512565014092 Walker B motif; other site 512565014093 arginine finger; other site 512565014094 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 512565014095 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 512565014096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565014097 S-adenosylmethionine binding site [chemical binding]; other site 512565014098 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 512565014099 Peptidase family M50; Region: Peptidase_M50; pfam02163 512565014100 active site 512565014101 putative substrate binding region [chemical binding]; other site 512565014102 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512565014103 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512565014104 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565014105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565014106 active site 512565014107 phosphorylation site [posttranslational modification] 512565014108 intermolecular recognition site; other site 512565014109 dimerization interface [polypeptide binding]; other site 512565014110 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565014111 DNA binding residues [nucleotide binding] 512565014112 dimerization interface [polypeptide binding]; other site 512565014113 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 512565014114 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565014115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565014116 motif II; other site 512565014117 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 512565014118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565014119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565014120 active site 512565014121 catalytic tetrad [active] 512565014122 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565014123 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565014124 Walker A/P-loop; other site 512565014125 ATP binding site [chemical binding]; other site 512565014126 Q-loop/lid; other site 512565014127 ABC transporter signature motif; other site 512565014128 Walker B; other site 512565014129 D-loop; other site 512565014130 H-loop/switch region; other site 512565014131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565014132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512565014133 FtsX-like permease family; Region: FtsX; pfam02687 512565014134 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565014135 PAC2 family; Region: PAC2; pfam09754 512565014136 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565014137 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565014138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565014139 non-specific DNA binding site [nucleotide binding]; other site 512565014140 sequence-specific DNA binding site [nucleotide binding]; other site 512565014141 salt bridge; other site 512565014142 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565014143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565014144 DNA-binding site [nucleotide binding]; DNA binding site 512565014145 UTRA domain; Region: UTRA; pfam07702 512565014146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565014147 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 512565014148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565014149 Histidine kinase; Region: HisKA_3; pfam07730 512565014150 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565014151 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565014152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565014153 active site 512565014154 phosphorylation site [posttranslational modification] 512565014155 intermolecular recognition site; other site 512565014156 dimerization interface [polypeptide binding]; other site 512565014157 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565014158 DNA binding residues [nucleotide binding] 512565014159 dimerization interface [polypeptide binding]; other site 512565014160 Homeodomain-like domain; Region: HTH_23; cl17451 512565014161 Winged helix-turn helix; Region: HTH_29; pfam13551 512565014162 Integrase core domain; Region: rve; pfam00665 512565014163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 512565014164 Integrase core domain; Region: rve_3; pfam13683 512565014165 Histidine kinase; Region: HisKA_3; pfam07730 512565014166 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565014167 ATP binding site [chemical binding]; other site 512565014168 Mg2+ binding site [ion binding]; other site 512565014169 G-X-G motif; other site 512565014170 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565014171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565014172 active site 512565014173 phosphorylation site [posttranslational modification] 512565014174 intermolecular recognition site; other site 512565014175 dimerization interface [polypeptide binding]; other site 512565014176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565014177 DNA binding residues [nucleotide binding] 512565014178 dimerization interface [polypeptide binding]; other site 512565014179 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565014180 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 512565014181 active site 512565014182 HIGH motif; other site 512565014183 nucleotide binding site [chemical binding]; other site 512565014184 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565014185 active site 512565014186 KMSKS motif; other site 512565014187 conserved hypothetical protein; Region: TIGR03843 512565014188 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 512565014189 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565014190 catalytic core [active] 512565014191 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565014192 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 512565014193 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565014194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565014195 active site 512565014196 catalytic tetrad [active] 512565014197 hypothetical protein; Provisional; Region: PRK07906 512565014198 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 512565014199 putative metal binding site [ion binding]; other site 512565014200 Hemerythrin-like domain; Region: Hr-like; cd12108 512565014201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565014202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565014203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512565014204 dimerization interface [polypeptide binding]; other site 512565014205 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 512565014206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565014207 Walker A motif; other site 512565014208 ATP binding site [chemical binding]; other site 512565014209 Walker B motif; other site 512565014210 arginine finger; other site 512565014211 UvrB/uvrC motif; Region: UVR; pfam02151 512565014212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565014213 Walker A motif; other site 512565014214 ATP binding site [chemical binding]; other site 512565014215 Walker B motif; other site 512565014216 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 512565014217 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 512565014218 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565014219 Cupin superfamily protein; Region: Cupin_4; pfam08007 512565014220 Cupin-like domain; Region: Cupin_8; pfam13621 512565014221 Protein of unknown function DUF72; Region: DUF72; pfam01904 512565014222 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 512565014223 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512565014224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565014225 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565014226 DNA binding site [nucleotide binding] 512565014227 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 512565014228 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 512565014229 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 512565014230 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 512565014231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 512565014232 nucleotide binding region [chemical binding]; other site 512565014233 ATP-binding site [chemical binding]; other site 512565014234 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565014235 NAD(P) binding site [chemical binding]; other site 512565014236 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565014237 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565014238 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 512565014239 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 512565014240 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565014241 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 512565014242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565014243 putative ADP-binding pocket [chemical binding]; other site 512565014244 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565014245 CheB methylesterase; Region: CheB_methylest; pfam01339 512565014246 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 512565014247 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 512565014248 PAS fold; Region: PAS_4; pfam08448 512565014249 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565014250 PAS domain; Region: PAS_9; pfam13426 512565014251 putative active site [active] 512565014252 heme pocket [chemical binding]; other site 512565014253 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565014254 anti sigma factor interaction site; other site 512565014255 regulatory phosphorylation site [posttranslational modification]; other site 512565014256 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565014257 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565014258 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 512565014259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565014260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565014261 DNA binding residues [nucleotide binding] 512565014262 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565014263 anti sigma factor interaction site; other site 512565014264 regulatory phosphorylation site [posttranslational modification]; other site 512565014265 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565014266 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 512565014267 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 512565014268 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 512565014269 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 512565014270 catalytic triad [active] 512565014271 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 512565014272 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 512565014273 Walker A motif; other site 512565014274 homodimer interface [polypeptide binding]; other site 512565014275 ATP binding site [chemical binding]; other site 512565014276 hydroxycobalamin binding site [chemical binding]; other site 512565014277 Walker B motif; other site 512565014278 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 512565014279 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 512565014280 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 512565014281 metal ion-dependent adhesion site (MIDAS); other site 512565014282 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 512565014283 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 512565014284 N- and C-terminal domain interface [polypeptide binding]; other site 512565014285 active site 512565014286 catalytic site [active] 512565014287 metal binding site [ion binding]; metal-binding site 512565014288 carbohydrate binding site [chemical binding]; other site 512565014289 ATP binding site [chemical binding]; other site 512565014290 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 512565014291 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 512565014292 dimer interface [polypeptide binding]; other site 512565014293 active site 512565014294 citrylCoA binding site [chemical binding]; other site 512565014295 NADH binding [chemical binding]; other site 512565014296 cationic pore residues; other site 512565014297 oxalacetate/citrate binding site [chemical binding]; other site 512565014298 coenzyme A binding site [chemical binding]; other site 512565014299 catalytic triad [active] 512565014300 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512565014301 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565014302 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565014303 metal binding site [ion binding]; metal-binding site 512565014304 active site 512565014305 I-site; other site 512565014306 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565014307 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 512565014308 putative catalytic site [active] 512565014309 putative phosphate binding site [ion binding]; other site 512565014310 active site 512565014311 metal binding site A [ion binding]; metal-binding site 512565014312 DNA binding site [nucleotide binding] 512565014313 putative AP binding site [nucleotide binding]; other site 512565014314 putative metal binding site B [ion binding]; other site 512565014315 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 512565014316 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565014317 B12 binding domain; Region: B12-binding_2; pfam02607 512565014318 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 512565014319 B12 binding domain; Region: B12-binding; pfam02310 512565014320 B12 binding site [chemical binding]; other site 512565014321 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 512565014322 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 512565014323 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565014324 ATP binding site [chemical binding]; other site 512565014325 putative Mg++ binding site [ion binding]; other site 512565014326 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565014327 nucleotide binding region [chemical binding]; other site 512565014328 ATP-binding site [chemical binding]; other site 512565014329 Helicase associated domain (HA2); Region: HA2; pfam04408 512565014330 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 512565014331 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 512565014332 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 512565014333 Response regulator receiver domain; Region: Response_reg; pfam00072 512565014334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565014335 active site 512565014336 phosphorylation site [posttranslational modification] 512565014337 intermolecular recognition site; other site 512565014338 dimerization interface [polypeptide binding]; other site 512565014339 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 512565014340 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565014341 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565014342 dimer interface [polypeptide binding]; other site 512565014343 phosphorylation site [posttranslational modification] 512565014344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565014345 ATP binding site [chemical binding]; other site 512565014346 Mg2+ binding site [ion binding]; other site 512565014347 G-X-G motif; other site 512565014348 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 512565014349 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 512565014350 active site 512565014351 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 512565014352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565014353 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565014354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565014355 DNA binding residues [nucleotide binding] 512565014356 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565014357 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565014358 nucleotide binding site [chemical binding]; other site 512565014359 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 512565014360 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 512565014361 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 512565014362 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565014363 active site 512565014364 homodimer interface [polypeptide binding]; other site 512565014365 catalytic site [active] 512565014366 acceptor binding site [chemical binding]; other site 512565014367 trehalose synthase; Region: treS_nterm; TIGR02456 512565014368 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 512565014369 active site 512565014370 catalytic site [active] 512565014371 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 512565014372 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 512565014373 glycogen branching enzyme; Provisional; Region: PRK05402 512565014374 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 512565014375 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 512565014376 active site 512565014377 catalytic site [active] 512565014378 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 512565014379 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565014380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565014381 Protein of unknown function (DUF419); Region: DUF419; pfam04237 512565014382 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 512565014383 active site 512565014384 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 512565014385 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 512565014386 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 512565014387 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 512565014388 RNA binding site [nucleotide binding]; other site 512565014389 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565014390 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565014391 active site 512565014392 ATP binding site [chemical binding]; other site 512565014393 substrate binding site [chemical binding]; other site 512565014394 activation loop (A-loop); other site 512565014395 PspC domain; Region: PspC; pfam04024 512565014396 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 512565014397 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 512565014398 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 512565014399 intracellular protease, PfpI family; Region: PfpI; TIGR01382 512565014400 conserved cys residue [active] 512565014401 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565014402 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512565014403 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 512565014404 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 512565014405 SLBB domain; Region: SLBB; pfam10531 512565014406 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 512565014407 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 512565014408 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 512565014409 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 512565014410 Cellulose binding domain; Region: CBM_2; pfam00553 512565014411 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 512565014412 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565014413 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 512565014414 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565014415 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565014416 metal binding site [ion binding]; metal-binding site 512565014417 active site 512565014418 I-site; other site 512565014419 acyl-coenzyme A oxidase; Region: PLN02526 512565014420 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565014421 active site 512565014422 glycyl-tRNA synthetase; Provisional; Region: PRK14908 512565014423 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565014424 motif 1; other site 512565014425 dimer interface [polypeptide binding]; other site 512565014426 active site 512565014427 motif 2; other site 512565014428 motif 3; other site 512565014429 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 512565014430 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 512565014431 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 512565014432 putative active site [active] 512565014433 catalytic site [active] 512565014434 putative metal binding site [ion binding]; other site 512565014435 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 512565014436 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565014437 FOG: PKD repeat [General function prediction only]; Region: COG3291 512565014438 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 512565014439 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565014440 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565014441 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 512565014442 inhibitor-cofactor binding pocket; inhibition site 512565014443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565014444 catalytic residue [active] 512565014445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565014446 DNA-binding site [nucleotide binding]; DNA binding site 512565014447 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565014448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565014449 homodimer interface [polypeptide binding]; other site 512565014450 catalytic residue [active] 512565014451 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 512565014452 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 512565014453 active site 512565014454 catalytic triad [active] 512565014455 dimer interface [polypeptide binding]; other site 512565014456 phenylhydantoinase; Validated; Region: PRK08323 512565014457 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 512565014458 tetramer interface [polypeptide binding]; other site 512565014459 active site 512565014460 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565014461 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 512565014462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014463 dimer interface [polypeptide binding]; other site 512565014464 conserved gate region; other site 512565014465 ABC-ATPase subunit interface; other site 512565014466 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565014467 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565014468 Walker A/P-loop; other site 512565014469 ATP binding site [chemical binding]; other site 512565014470 Q-loop/lid; other site 512565014471 ABC transporter signature motif; other site 512565014472 Walker B; other site 512565014473 D-loop; other site 512565014474 H-loop/switch region; other site 512565014475 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565014476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565014477 NMT1/THI5 like; Region: NMT1; pfam09084 512565014478 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 512565014479 PAS domain S-box; Region: sensory_box; TIGR00229 512565014480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565014481 putative active site [active] 512565014482 heme pocket [chemical binding]; other site 512565014483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565014484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565014485 metal binding site [ion binding]; metal-binding site 512565014486 active site 512565014487 I-site; other site 512565014488 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565014489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565014490 active site 512565014491 ATP binding site [chemical binding]; other site 512565014492 substrate binding site [chemical binding]; other site 512565014493 substrate binding site [chemical binding]; other site 512565014494 activation loop (A-loop); other site 512565014495 activation loop (A-loop); other site 512565014496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565014497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565014498 DNA binding site [nucleotide binding] 512565014499 domain linker motif; other site 512565014500 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 512565014501 putative dimerization interface [polypeptide binding]; other site 512565014502 putative ligand binding site [chemical binding]; other site 512565014503 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 512565014504 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 512565014505 conserved cys residue [active] 512565014506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565014507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565014508 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 512565014509 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 512565014510 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 512565014511 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565014512 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565014513 DNA binding site [nucleotide binding] 512565014514 domain linker motif; other site 512565014515 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565014516 ligand binding site [chemical binding]; other site 512565014517 dimerization interface [polypeptide binding]; other site 512565014518 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565014519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565014520 non-specific DNA binding site [nucleotide binding]; other site 512565014521 salt bridge; other site 512565014522 sequence-specific DNA binding site [nucleotide binding]; other site 512565014523 Cupin domain; Region: Cupin_2; pfam07883 512565014524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565014525 S-adenosylmethionine binding site [chemical binding]; other site 512565014526 Amb_all domain; Region: Amb_all; smart00656 512565014527 Cupin domain; Region: Cupin_2; pfam07883 512565014528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565014529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565014530 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 512565014531 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 512565014532 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 512565014533 glucuronate isomerase; Reviewed; Region: PRK02925 512565014534 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 512565014535 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565014536 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565014537 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512565014538 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565014539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565014540 DNA binding site [nucleotide binding] 512565014541 domain linker motif; other site 512565014542 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565014543 dimerization interface [polypeptide binding]; other site 512565014544 ligand binding site [chemical binding]; other site 512565014545 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565014546 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565014547 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512565014548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014549 dimer interface [polypeptide binding]; other site 512565014550 conserved gate region; other site 512565014551 putative PBP binding loops; other site 512565014552 ABC-ATPase subunit interface; other site 512565014553 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565014554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014555 dimer interface [polypeptide binding]; other site 512565014556 conserved gate region; other site 512565014557 putative PBP binding loops; other site 512565014558 ABC-ATPase subunit interface; other site 512565014559 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565014560 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 512565014561 AsnC family; Region: AsnC_trans_reg; pfam01037 512565014562 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 512565014563 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 512565014564 hexamer interface [polypeptide binding]; other site 512565014565 ligand binding site [chemical binding]; other site 512565014566 putative active site [active] 512565014567 NAD(P) binding site [chemical binding]; other site 512565014568 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565014569 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 512565014570 aromatic chitin/cellulose binding site residues [chemical binding]; other site 512565014571 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 512565014572 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 512565014573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014574 dimer interface [polypeptide binding]; other site 512565014575 conserved gate region; other site 512565014576 ABC-ATPase subunit interface; other site 512565014577 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 512565014578 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 512565014579 Walker A/P-loop; other site 512565014580 ATP binding site [chemical binding]; other site 512565014581 Q-loop/lid; other site 512565014582 ABC transporter signature motif; other site 512565014583 Walker B; other site 512565014584 D-loop; other site 512565014585 H-loop/switch region; other site 512565014586 NIL domain; Region: NIL; pfam09383 512565014587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565014588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565014589 active site 512565014590 phosphorylation site [posttranslational modification] 512565014591 intermolecular recognition site; other site 512565014592 dimerization interface [polypeptide binding]; other site 512565014593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565014594 DNA binding residues [nucleotide binding] 512565014595 dimerization interface [polypeptide binding]; other site 512565014596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565014597 Histidine kinase; Region: HisKA_3; pfam07730 512565014598 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 512565014599 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 512565014600 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 512565014601 FAD binding pocket [chemical binding]; other site 512565014602 FAD binding motif [chemical binding]; other site 512565014603 phosphate binding motif [ion binding]; other site 512565014604 beta-alpha-beta structure motif; other site 512565014605 NAD binding pocket [chemical binding]; other site 512565014606 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565014607 catalytic loop [active] 512565014608 iron binding site [ion binding]; other site 512565014609 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 512565014610 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 512565014611 putative di-iron ligands [ion binding]; other site 512565014612 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 512565014613 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 512565014614 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 512565014615 NAD(P) binding site [chemical binding]; other site 512565014616 LDH/MDH dimer interface [polypeptide binding]; other site 512565014617 substrate binding site [chemical binding]; other site 512565014618 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565014619 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 512565014620 substrate binding site [chemical binding]; other site 512565014621 ATP binding site [chemical binding]; other site 512565014622 GAF domain; Region: GAF; pfam01590 512565014623 HAMP domain; Region: HAMP; pfam00672 512565014624 dimerization interface [polypeptide binding]; other site 512565014625 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565014626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565014627 dimer interface [polypeptide binding]; other site 512565014628 putative CheW interface [polypeptide binding]; other site 512565014629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565014630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565014631 putative substrate translocation pore; other site 512565014632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565014633 putative substrate translocation pore; other site 512565014634 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565014635 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 512565014636 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 512565014637 FAD binding pocket [chemical binding]; other site 512565014638 FAD binding motif [chemical binding]; other site 512565014639 phosphate binding motif [ion binding]; other site 512565014640 beta-alpha-beta structure motif; other site 512565014641 NAD binding pocket [chemical binding]; other site 512565014642 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 512565014643 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 512565014644 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 512565014645 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565014646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565014647 dimerization interface [polypeptide binding]; other site 512565014648 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565014649 dimer interface [polypeptide binding]; other site 512565014650 putative CheW interface [polypeptide binding]; other site 512565014651 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 512565014652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565014653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565014654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565014655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014656 dimer interface [polypeptide binding]; other site 512565014657 conserved gate region; other site 512565014658 putative PBP binding loops; other site 512565014659 ABC-ATPase subunit interface; other site 512565014660 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565014661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014662 dimer interface [polypeptide binding]; other site 512565014663 conserved gate region; other site 512565014664 putative PBP binding loops; other site 512565014665 ABC-ATPase subunit interface; other site 512565014666 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565014667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565014668 DNA binding site [nucleotide binding] 512565014669 domain linker motif; other site 512565014670 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 512565014671 putative dimerization interface [polypeptide binding]; other site 512565014672 putative ligand binding site [chemical binding]; other site 512565014673 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 512565014674 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 512565014675 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 512565014676 DNA binding site [nucleotide binding] 512565014677 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565014678 Predicted ATPase [General function prediction only]; Region: COG3903 512565014679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565014680 putative Zn2+ binding site [ion binding]; other site 512565014681 putative DNA binding site [nucleotide binding]; other site 512565014682 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565014683 hydrophobic ligand binding site; other site 512565014684 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 512565014685 MMPL family; Region: MMPL; pfam03176 512565014686 MMPL family; Region: MMPL; pfam03176 512565014687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565014688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565014689 MarR family; Region: MarR_2; cl17246 512565014690 Part of AAA domain; Region: AAA_19; pfam13245 512565014691 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 512565014692 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 512565014693 active site 512565014694 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 512565014695 L-arabinose isomerase; Provisional; Region: PRK02929 512565014696 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 512565014697 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 512565014698 trimer interface [polypeptide binding]; other site 512565014699 putative substrate binding site [chemical binding]; other site 512565014700 putative metal binding site [ion binding]; other site 512565014701 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565014702 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565014703 TM-ABC transporter signature motif; other site 512565014704 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565014705 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512565014706 TM-ABC transporter signature motif; other site 512565014707 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 512565014708 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565014709 Walker A/P-loop; other site 512565014710 ATP binding site [chemical binding]; other site 512565014711 Q-loop/lid; other site 512565014712 ABC transporter signature motif; other site 512565014713 Walker B; other site 512565014714 D-loop; other site 512565014715 H-loop/switch region; other site 512565014716 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512565014717 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 512565014718 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 512565014719 putative ligand binding site [chemical binding]; other site 512565014720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565014721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565014722 DNA binding site [nucleotide binding] 512565014723 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 512565014724 ligand binding site [chemical binding]; other site 512565014725 dimerization interface (open form) [polypeptide binding]; other site 512565014726 dimerization interface (closed form) [polypeptide binding]; other site 512565014727 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 512565014728 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 512565014729 intersubunit interface [polypeptide binding]; other site 512565014730 active site 512565014731 Zn2+ binding site [ion binding]; other site 512565014732 PBP superfamily domain; Region: PBP_like_2; cl17296 512565014733 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 512565014734 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 512565014735 Part of AAA domain; Region: AAA_19; pfam13245 512565014736 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565014737 AAA domain; Region: AAA_12; pfam13087 512565014738 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565014739 putative active site [active] 512565014740 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 512565014741 HIRAN domain; Region: HIRAN; cl07418 512565014742 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 512565014743 Prostaglandin dehydrogenases; Region: PGDH; cd05288 512565014744 NAD(P) binding site [chemical binding]; other site 512565014745 substrate binding site [chemical binding]; other site 512565014746 dimer interface [polypeptide binding]; other site 512565014747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565014748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565014749 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 512565014750 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 512565014751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565014752 dimerization interface [polypeptide binding]; other site 512565014753 putative DNA binding site [nucleotide binding]; other site 512565014754 putative Zn2+ binding site [ion binding]; other site 512565014755 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 512565014756 putative hydrophobic ligand binding site [chemical binding]; other site 512565014757 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565014758 dimer interface [polypeptide binding]; other site 512565014759 putative CheW interface [polypeptide binding]; other site 512565014760 PilZ domain; Region: PilZ; pfam07238 512565014761 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 512565014762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565014763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565014764 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565014765 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565014766 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512565014767 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565014768 Walker A/P-loop; other site 512565014769 ATP binding site [chemical binding]; other site 512565014770 Q-loop/lid; other site 512565014771 ABC transporter signature motif; other site 512565014772 Walker B; other site 512565014773 D-loop; other site 512565014774 H-loop/switch region; other site 512565014775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565014776 active site 512565014777 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565014778 GAF domain; Region: GAF; pfam01590 512565014779 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565014780 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 512565014781 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 512565014782 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 512565014783 active site 512565014784 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 512565014785 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565014786 putative catalytic site [active] 512565014787 putative metal binding site [ion binding]; other site 512565014788 putative phosphate binding site [ion binding]; other site 512565014789 Jacalin-like lectin domain; Region: Jacalin_like; cl03205 512565014790 putative sugar binding site [chemical binding]; other site 512565014791 Protease prsW family; Region: PrsW-protease; pfam13367 512565014792 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 512565014793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565014794 catalytic residue [active] 512565014795 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512565014796 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 512565014797 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512565014798 Caspase domain; Region: Peptidase_C14; pfam00656 512565014799 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565014800 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565014801 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565014802 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 512565014803 putative dimerization interface [polypeptide binding]; other site 512565014804 Proline dehydrogenase; Region: Pro_dh; cl03282 512565014805 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565014806 NAD(P) binding site [chemical binding]; other site 512565014807 catalytic residues [active] 512565014808 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 512565014809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565014810 motif II; other site 512565014811 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 512565014812 FAD binding domain; Region: FAD_binding_4; pfam01565 512565014813 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565014814 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565014815 NAD(P) binding site [chemical binding]; other site 512565014816 catalytic residues [active] 512565014817 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565014818 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565014819 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565014820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565014821 NAD-dependent benzaldehyde dehydrogenase II-like; Region: ALDH_BenzADH; cd07152 512565014822 NAD(P) binding site [chemical binding]; other site 512565014823 catalytic residues [active] 512565014824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565014825 active site 512565014826 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565014827 catalytic tetrad [active] 512565014828 YGGT family; Region: YGGT; pfam02325 512565014829 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 512565014830 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565014831 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 512565014832 AAA domain; Region: AAA_30; pfam13604 512565014833 Family description; Region: UvrD_C_2; pfam13538 512565014834 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 512565014835 YibE/F-like protein; Region: YibE_F; pfam07907 512565014836 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 512565014837 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565014838 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565014839 dimer interface [polypeptide binding]; other site 512565014840 putative CheW interface [polypeptide binding]; other site 512565014841 DAK2 domain; Region: Dak2; cl03685 512565014842 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 512565014843 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 512565014844 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 512565014845 active site 512565014846 active pocket/dimerization site; other site 512565014847 phosphorylation site [posttranslational modification] 512565014848 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 512565014849 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565014850 dimer interface [polypeptide binding]; other site 512565014851 active site 512565014852 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 512565014853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565014854 NAD(P) binding site [chemical binding]; other site 512565014855 active site 512565014856 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565014857 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565014858 active site 1 [active] 512565014859 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565014860 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565014861 active site 512565014862 acyl-CoA synthetase; Validated; Region: PRK07788 512565014863 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565014864 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 512565014865 acyl-activating enzyme (AAE) consensus motif; other site 512565014866 putative AMP binding site [chemical binding]; other site 512565014867 putative active site [active] 512565014868 acyl-activating enzyme (AAE) consensus motif; other site 512565014869 putative CoA binding site [chemical binding]; other site 512565014870 oxidoreductase; Provisional; Region: PRK12743 512565014871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565014872 NAD(P) binding site [chemical binding]; other site 512565014873 active site 512565014874 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 512565014875 Part of AAA domain; Region: AAA_19; pfam13245 512565014876 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565014877 AAA domain; Region: AAA_12; pfam13087 512565014878 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 512565014879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 512565014880 tellurite resistance protein TehB; Provisional; Region: PRK11207 512565014881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565014882 S-adenosylmethionine binding site [chemical binding]; other site 512565014883 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 512565014884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565014885 non-specific DNA binding site [nucleotide binding]; other site 512565014886 salt bridge; other site 512565014887 sequence-specific DNA binding site [nucleotide binding]; other site 512565014888 Cupin domain; Region: Cupin_2; pfam07883 512565014889 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 512565014890 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 512565014891 NAD binding site [chemical binding]; other site 512565014892 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 512565014893 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 512565014894 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 512565014895 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 512565014896 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 512565014897 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 512565014898 active site 512565014899 Predicted transcriptional regulator [Transcription]; Region: COG1959 512565014900 Transcriptional regulator; Region: Rrf2; cl17282 512565014901 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 512565014902 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 512565014903 heme-binding site [chemical binding]; other site 512565014904 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 512565014905 FAD binding pocket [chemical binding]; other site 512565014906 FAD binding motif [chemical binding]; other site 512565014907 phosphate binding motif [ion binding]; other site 512565014908 beta-alpha-beta structure motif; other site 512565014909 NAD binding pocket [chemical binding]; other site 512565014910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 512565014911 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 512565014912 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 512565014913 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565014914 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565014915 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565014916 NAD-dependent deacetylase; Provisional; Region: PRK00481 512565014917 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 512565014918 NAD+ binding site [chemical binding]; other site 512565014919 substrate binding site [chemical binding]; other site 512565014920 Zn binding site [ion binding]; other site 512565014921 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565014922 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 512565014923 acyl-activating enzyme (AAE) consensus motif; other site 512565014924 AMP binding site [chemical binding]; other site 512565014925 active site 512565014926 CoA binding site [chemical binding]; other site 512565014927 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 512565014928 putative active site [active] 512565014929 putative catalytic site [active] 512565014930 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 512565014931 active site 512565014932 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06077 512565014933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565014934 NAD(P) binding site [chemical binding]; other site 512565014935 active site 512565014936 MarR family; Region: MarR_2; cl17246 512565014937 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565014938 amidase; Provisional; Region: PRK07487 512565014939 Amidase; Region: Amidase; cl11426 512565014940 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 512565014941 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565014942 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 512565014943 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 512565014944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565014945 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565014946 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 512565014947 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565014948 Walker A/P-loop; other site 512565014949 ATP binding site [chemical binding]; other site 512565014950 Q-loop/lid; other site 512565014951 ABC transporter signature motif; other site 512565014952 Walker B; other site 512565014953 D-loop; other site 512565014954 H-loop/switch region; other site 512565014955 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565014956 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565014957 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565014958 Walker A/P-loop; other site 512565014959 ATP binding site [chemical binding]; other site 512565014960 Q-loop/lid; other site 512565014961 ABC transporter signature motif; other site 512565014962 Walker B; other site 512565014963 D-loop; other site 512565014964 H-loop/switch region; other site 512565014965 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565014966 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512565014967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014968 dimer interface [polypeptide binding]; other site 512565014969 conserved gate region; other site 512565014970 putative PBP binding loops; other site 512565014971 ABC-ATPase subunit interface; other site 512565014972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565014973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565014974 dimer interface [polypeptide binding]; other site 512565014975 conserved gate region; other site 512565014976 putative PBP binding loops; other site 512565014977 ABC-ATPase subunit interface; other site 512565014978 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 512565014979 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 512565014980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565014981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565014982 metal binding site [ion binding]; metal-binding site 512565014983 active site 512565014984 I-site; other site 512565014985 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565014986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565014987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565014988 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565014989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565014990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565014991 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 512565014992 Part of AAA domain; Region: AAA_19; pfam13245 512565014993 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565014994 AAA domain; Region: AAA_12; pfam13087 512565014995 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565014996 putative active site [active] 512565014997 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 512565014998 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 512565014999 NAD(P) binding site [chemical binding]; other site 512565015000 homodimer interface [polypeptide binding]; other site 512565015001 substrate binding site [chemical binding]; other site 512565015002 active site 512565015003 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 512565015004 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 512565015005 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565015006 Methyltransferase domain; Region: Methyltransf_24; pfam13578 512565015007 transketolase; Reviewed; Region: PRK05899 512565015008 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 512565015009 TPP-binding site [chemical binding]; other site 512565015010 dimer interface [polypeptide binding]; other site 512565015011 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 512565015012 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512565015013 PYR/PP interface [polypeptide binding]; other site 512565015014 dimer interface [polypeptide binding]; other site 512565015015 TPP binding site [chemical binding]; other site 512565015016 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565015017 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 512565015018 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 512565015019 inhibitor-cofactor binding pocket; inhibition site 512565015020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565015021 catalytic residue [active] 512565015022 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565015023 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 512565015024 Ligand binding site; other site 512565015025 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565015026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565015027 catalytic residue [active] 512565015028 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 512565015029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565015030 Coenzyme A binding pocket [chemical binding]; other site 512565015031 Bacterial sugar transferase; Region: Bac_transf; pfam02397 512565015032 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 512565015033 O-Antigen ligase; Region: Wzy_C; pfam04932 512565015034 LexA repressor; Validated; Region: PRK00215 512565015035 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565015036 putative DNA binding site [nucleotide binding]; other site 512565015037 putative Zn2+ binding site [ion binding]; other site 512565015038 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 512565015039 Catalytic site [active] 512565015040 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565015041 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 512565015042 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 512565015043 TM-ABC transporter signature motif; other site 512565015044 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512565015045 TM-ABC transporter signature motif; other site 512565015046 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565015047 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512565015048 Walker A/P-loop; other site 512565015049 ATP binding site [chemical binding]; other site 512565015050 Q-loop/lid; other site 512565015051 ABC transporter signature motif; other site 512565015052 Walker B; other site 512565015053 D-loop; other site 512565015054 H-loop/switch region; other site 512565015055 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565015056 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512565015057 Walker A/P-loop; other site 512565015058 ATP binding site [chemical binding]; other site 512565015059 Q-loop/lid; other site 512565015060 ABC transporter signature motif; other site 512565015061 Walker B; other site 512565015062 D-loop; other site 512565015063 H-loop/switch region; other site 512565015064 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 512565015065 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565015066 PaaX-like protein; Region: PaaX; pfam07848 512565015067 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 512565015068 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 512565015069 Domain of unknown function (DUF718); Region: DUF718; pfam05336 512565015070 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 512565015071 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 512565015072 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 512565015073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565015074 thymidine kinase; Provisional; Region: PRK04296 512565015075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512565015076 Walker A motif; other site 512565015077 ATP binding site [chemical binding]; other site 512565015078 Walker B motif; other site 512565015079 arginine finger; other site 512565015080 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 512565015081 Catalytic site; other site 512565015082 Lamin Tail Domain; Region: LTD; pfam00932 512565015083 RDD family; Region: RDD; pfam06271 512565015084 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 512565015085 active site 512565015086 Zn binding site [ion binding]; other site 512565015087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565015088 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565015089 NACHT domain; Region: NACHT; pfam05729 512565015090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565015091 Walker A/P-loop; other site 512565015092 ATP binding site [chemical binding]; other site 512565015093 ABC transporter signature motif; other site 512565015094 Walker B; other site 512565015095 D-loop; other site 512565015096 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 512565015097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565015098 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565015099 active site 512565015100 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 512565015101 DUF35 OB-fold domain; Region: DUF35; pfam01796 512565015102 thiolase; Provisional; Region: PRK06158 512565015103 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 512565015104 active site 512565015105 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565015106 active site 2 [active] 512565015107 active site 1 [active] 512565015108 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 512565015109 active site 2 [active] 512565015110 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512565015111 putative active site [active] 512565015112 homotrimer interaction site [polypeptide binding]; other site 512565015113 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 512565015114 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 512565015115 CoA-transferase family III; Region: CoA_transf_3; pfam02515 512565015116 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 512565015117 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565015118 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 512565015119 putative active site [active] 512565015120 putative catalytic site [active] 512565015121 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565015122 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565015123 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565015124 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565015125 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 512565015126 metal binding site [ion binding]; metal-binding site 512565015127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565015128 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 512565015129 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565015130 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 512565015131 NAD(P) binding site [chemical binding]; other site 512565015132 catalytic residues [active] 512565015133 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 512565015134 tetramer interface [polypeptide binding]; other site 512565015135 active site 512565015136 Mg2+/Mn2+ binding site [ion binding]; other site 512565015137 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 512565015138 hypothetical protein; Provisional; Region: PRK07236 512565015139 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565015140 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565015141 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565015142 NAD(P) binding site [chemical binding]; other site 512565015143 catalytic residues [active] 512565015144 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 512565015145 Predicted amidohydrolase [General function prediction only]; Region: COG0388 512565015146 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 512565015147 active site 512565015148 catalytic triad [active] 512565015149 dimer interface [polypeptide binding]; other site 512565015150 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 512565015151 active site 512565015152 catalytic triad [active] 512565015153 dimer interface [polypeptide binding]; other site 512565015154 Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747 512565015155 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565015156 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 512565015157 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 512565015158 iron-sulfur cluster [ion binding]; other site 512565015159 [2Fe-2S] cluster binding site [ion binding]; other site 512565015160 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565015161 hydrophobic ligand binding site; other site 512565015162 Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747 512565015163 classical (c) SDRs; Region: SDR_c; cd05233 512565015164 NAD(P) binding site [chemical binding]; other site 512565015165 active site 512565015166 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 512565015167 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565015168 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512565015169 TM-ABC transporter signature motif; other site 512565015170 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 512565015171 TM-ABC transporter signature motif; other site 512565015172 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565015173 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512565015174 Walker A/P-loop; other site 512565015175 ATP binding site [chemical binding]; other site 512565015176 Q-loop/lid; other site 512565015177 ABC transporter signature motif; other site 512565015178 Walker B; other site 512565015179 D-loop; other site 512565015180 H-loop/switch region; other site 512565015181 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565015182 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512565015183 Walker A/P-loop; other site 512565015184 ATP binding site [chemical binding]; other site 512565015185 Q-loop/lid; other site 512565015186 ABC transporter signature motif; other site 512565015187 Walker B; other site 512565015188 D-loop; other site 512565015189 H-loop/switch region; other site 512565015190 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 512565015191 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565015192 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 512565015193 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 512565015194 Putative cyclase; Region: Cyclase; pfam04199 512565015195 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 512565015196 CoA-transferase family III; Region: CoA_transf_3; pfam02515 512565015197 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 512565015198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565015199 active site 512565015200 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 512565015201 oligomeric interface; other site 512565015202 homodimer interface [polypeptide binding]; other site 512565015203 putative active site [active] 512565015204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565015205 acyl-coenzyme A oxidase; Region: PLN02636 512565015206 active site 512565015207 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 512565015208 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 512565015209 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565015210 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 512565015211 acyl-activating enzyme (AAE) consensus motif; other site 512565015212 acyl-activating enzyme (AAE) consensus motif; other site 512565015213 putative AMP binding site [chemical binding]; other site 512565015214 putative active site [active] 512565015215 putative CoA binding site [chemical binding]; other site 512565015216 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 512565015217 active site 512565015218 catalytic residues [active] 512565015219 metal binding site [ion binding]; metal-binding site 512565015220 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 512565015221 CoA-transferase family III; Region: CoA_transf_3; pfam02515 512565015222 Isochorismatase family; Region: Isochorismatase; pfam00857 512565015223 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 512565015224 catalytic triad [active] 512565015225 conserved cis-peptide bond; other site 512565015226 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 512565015227 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 512565015228 transmembrane helices; other site 512565015229 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 512565015230 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 512565015231 DXD motif; other site 512565015232 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 512565015233 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 512565015234 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565015235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565015236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565015237 DNA binding residues [nucleotide binding] 512565015238 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 512565015239 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 512565015240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565015241 S-adenosylmethionine binding site [chemical binding]; other site 512565015242 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 512565015243 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 512565015244 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 512565015245 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 512565015246 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565015247 PBP superfamily domain; Region: PBP_like_2; cl17296 512565015248 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565015249 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565015250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015251 dimer interface [polypeptide binding]; other site 512565015252 conserved gate region; other site 512565015253 putative PBP binding loops; other site 512565015254 ABC-ATPase subunit interface; other site 512565015255 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512565015256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015257 dimer interface [polypeptide binding]; other site 512565015258 conserved gate region; other site 512565015259 putative PBP binding loops; other site 512565015260 ABC-ATPase subunit interface; other site 512565015261 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565015262 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565015263 DNA binding site [nucleotide binding] 512565015264 domain linker motif; other site 512565015265 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 512565015266 ligand binding site [chemical binding]; other site 512565015267 dimerization interface (open form) [polypeptide binding]; other site 512565015268 dimerization interface (closed form) [polypeptide binding]; other site 512565015269 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565015270 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565015271 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565015272 DNA binding residues [nucleotide binding] 512565015273 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 512565015274 substrate binding site [chemical binding]; other site 512565015275 active site 512565015276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565015277 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565015278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565015279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565015280 LysR substrate binding domain; Region: LysR_substrate; pfam03466 512565015281 dimerization interface [polypeptide binding]; other site 512565015282 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 512565015283 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 512565015284 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 512565015285 putative hydrophobic ligand binding site [chemical binding]; other site 512565015286 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565015287 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 512565015288 Ligand binding site; other site 512565015289 metal-binding site 512565015290 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 512565015291 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 512565015292 XdhC Rossmann domain; Region: XdhC_C; pfam13478 512565015293 metallochaperone-like domain; Region: TRASH; smart00746 512565015294 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 512565015295 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 512565015296 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 512565015297 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 512565015298 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 512565015299 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 512565015300 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 512565015301 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 512565015302 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 512565015303 XdhC Rossmann domain; Region: XdhC_C; pfam13478 512565015304 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 512565015305 putative homodimer interface [polypeptide binding]; other site 512565015306 putative homotetramer interface [polypeptide binding]; other site 512565015307 putative allosteric switch controlling residues; other site 512565015308 putative metal binding site [ion binding]; other site 512565015309 putative homodimer-homodimer interface [polypeptide binding]; other site 512565015310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 512565015311 metal-binding site [ion binding] 512565015312 potassium/proton antiporter; Reviewed; Region: PRK05326 512565015313 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 512565015314 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 512565015315 metal-binding site [ion binding] 512565015316 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512565015317 elongation factor Tu; Reviewed; Region: PRK12736 512565015318 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 512565015319 G1 box; other site 512565015320 GEF interaction site [polypeptide binding]; other site 512565015321 GTP/Mg2+ binding site [chemical binding]; other site 512565015322 Switch I region; other site 512565015323 G2 box; other site 512565015324 G3 box; other site 512565015325 Switch II region; other site 512565015326 G4 box; other site 512565015327 G5 box; other site 512565015328 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 512565015329 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 512565015330 Antibiotic Binding Site [chemical binding]; other site 512565015331 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565015332 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565015333 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 512565015334 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 512565015335 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 512565015336 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 512565015337 active site 512565015338 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565015339 Ca binding site [ion binding]; other site 512565015340 catalytic site [active] 512565015341 Aamy_C domain; Region: Aamy_C; smart00632 512565015342 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 512565015343 starch-binding site 1 [chemical binding]; other site 512565015344 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 512565015345 starch-binding site 2 [chemical binding]; other site 512565015346 starch-binding site 1 [chemical binding]; other site 512565015347 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 512565015348 glycerol kinase; Provisional; Region: glpK; PRK00047 512565015349 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 512565015350 N- and C-terminal domain interface [polypeptide binding]; other site 512565015351 active site 512565015352 MgATP binding site [chemical binding]; other site 512565015353 catalytic site [active] 512565015354 metal binding site [ion binding]; metal-binding site 512565015355 putative homotetramer interface [polypeptide binding]; other site 512565015356 glycerol binding site [chemical binding]; other site 512565015357 homodimer interface [polypeptide binding]; other site 512565015358 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 512565015359 amphipathic channel; other site 512565015360 Asn-Pro-Ala signature motifs; other site 512565015361 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 512565015362 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565015363 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565015364 glycerol kinase; Provisional; Region: glpK; PRK00047 512565015365 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565015366 nucleotide binding site [chemical binding]; other site 512565015367 Hemerythrin-like domain; Region: Hr-like; cd12108 512565015368 Fe binding site [ion binding]; other site 512565015369 PAS domain; Region: PAS_9; pfam13426 512565015370 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 512565015371 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565015372 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565015373 quinohemoprotein amine dehydrogenase, beta subunit; Region: QH_beta; TIGR03907 512565015374 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565015375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565015376 putative substrate translocation pore; other site 512565015377 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 512565015378 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 512565015379 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 512565015380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 512565015381 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565015382 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 512565015383 putative active site [active] 512565015384 putative metal binding site [ion binding]; other site 512565015385 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 512565015386 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 512565015387 inhibitor-cofactor binding pocket; inhibition site 512565015388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565015389 catalytic residue [active] 512565015390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565015391 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 512565015392 Chain length determinant protein; Region: Wzz; cl15801 512565015393 AAA domain; Region: AAA_31; pfam13614 512565015394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565015395 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 512565015396 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 512565015397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565015398 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 512565015399 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 512565015400 putative active site [active] 512565015401 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 512565015402 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 512565015403 NAD binding site [chemical binding]; other site 512565015404 catalytic Zn binding site [ion binding]; other site 512565015405 structural Zn binding site [ion binding]; other site 512565015406 Bacterial sugar transferase; Region: Bac_transf; pfam02397 512565015407 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 512565015408 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565015409 NAD(P) binding site [chemical binding]; other site 512565015410 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 512565015411 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 512565015412 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 512565015413 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565015414 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 512565015415 NAD(P) binding site [chemical binding]; other site 512565015416 homodimer interface [polypeptide binding]; other site 512565015417 substrate binding site [chemical binding]; other site 512565015418 active site 512565015419 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565015420 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565015421 VanZ like family; Region: VanZ; cl01971 512565015422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565015423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565015424 DNA binding residues [nucleotide binding] 512565015425 dimerization interface [polypeptide binding]; other site 512565015426 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 512565015427 active site 512565015428 Zn binding site [ion binding]; other site 512565015429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512565015430 Walker A motif; other site 512565015431 ATP binding site [chemical binding]; other site 512565015432 Phosphotransferase enzyme family; Region: APH; pfam01636 512565015433 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565015434 active site 512565015435 substrate binding site [chemical binding]; other site 512565015436 ATP binding site [chemical binding]; other site 512565015437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565015438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565015439 putative substrate translocation pore; other site 512565015440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565015441 CAAX protease self-immunity; Region: Abi; pfam02517 512565015442 elongation factor G; Reviewed; Region: PRK13351 512565015443 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565015444 G1 box; other site 512565015445 GTP/Mg2+ binding site [chemical binding]; other site 512565015446 G2 box; other site 512565015447 Switch I region; other site 512565015448 G3 box; other site 512565015449 Switch II region; other site 512565015450 G4 box; other site 512565015451 G5 box; other site 512565015452 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 512565015453 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 512565015454 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 512565015455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565015456 S-adenosylmethionine binding site [chemical binding]; other site 512565015457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565015458 Coenzyme A binding pocket [chemical binding]; other site 512565015459 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565015460 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 512565015461 nudix motif; other site 512565015462 RibD C-terminal domain; Region: RibD_C; cl17279 512565015463 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 512565015464 YcfA-like protein; Region: YcfA; pfam07927 512565015465 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565015466 classical (c) SDRs; Region: SDR_c; cd05233 512565015467 NAD(P) binding site [chemical binding]; other site 512565015468 active site 512565015469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565015470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565015471 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565015472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565015473 S-adenosylmethionine binding site [chemical binding]; other site 512565015474 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 512565015475 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 512565015476 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 512565015477 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 512565015478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565015479 active site 512565015480 phosphorylation site [posttranslational modification] 512565015481 intermolecular recognition site; other site 512565015482 dimerization interface [polypeptide binding]; other site 512565015483 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 512565015484 PAS domain; Region: PAS; smart00091 512565015485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565015486 ATP binding site [chemical binding]; other site 512565015487 Mg2+ binding site [ion binding]; other site 512565015488 G-X-G motif; other site 512565015489 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 512565015490 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 512565015491 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 512565015492 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565015493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565015494 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 512565015495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565015496 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 512565015497 Walker A/P-loop; other site 512565015498 ATP binding site [chemical binding]; other site 512565015499 Q-loop/lid; other site 512565015500 ABC transporter signature motif; other site 512565015501 Walker B; other site 512565015502 D-loop; other site 512565015503 H-loop/switch region; other site 512565015504 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565015505 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565015506 Predicted ATPase [General function prediction only]; Region: COG3903 512565015507 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 512565015508 TrkA-N domain; Region: TrkA_N; pfam02254 512565015509 TrkA-C domain; Region: TrkA_C; pfam02080 512565015510 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 512565015511 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 512565015512 Amb_all domain; Region: Amb_all; smart00656 512565015513 Starch binding domain; Region: CBM_20; pfam00686 512565015514 starch-binding site 2 [chemical binding]; other site 512565015515 starch-binding site 1 [chemical binding]; other site 512565015516 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565015517 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 512565015518 Clp amino terminal domain; Region: Clp_N; pfam02861 512565015519 Clp amino terminal domain; Region: Clp_N; pfam02861 512565015520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565015521 Walker A motif; other site 512565015522 ATP binding site [chemical binding]; other site 512565015523 Walker B motif; other site 512565015524 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 512565015525 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 512565015526 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565015527 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 512565015528 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565015529 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 512565015530 PA/protease or protease-like domain interface [polypeptide binding]; other site 512565015531 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 512565015532 Peptidase family M28; Region: Peptidase_M28; pfam04389 512565015533 active site 512565015534 metal binding site [ion binding]; metal-binding site 512565015535 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565015536 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 512565015537 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 512565015538 nucleophile elbow; other site 512565015539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565015540 Coenzyme A binding pocket [chemical binding]; other site 512565015541 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 512565015542 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 512565015543 active site 512565015544 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 512565015545 homodimer interface [polypeptide binding]; other site 512565015546 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 512565015547 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 512565015548 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565015549 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 512565015550 DXD motif; other site 512565015551 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 512565015552 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 512565015553 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565015554 acyl-activating enzyme (AAE) consensus motif; other site 512565015555 AMP binding site [chemical binding]; other site 512565015556 active site 512565015557 CoA binding site [chemical binding]; other site 512565015558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565015559 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 512565015560 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 512565015561 active site 512565015562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565015563 NAD(P) binding site [chemical binding]; other site 512565015564 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 512565015565 Condensation domain; Region: Condensation; pfam00668 512565015566 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 512565015567 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 512565015568 acyl-activating enzyme (AAE) consensus motif; other site 512565015569 AMP binding site [chemical binding]; other site 512565015570 Condensation domain; Region: Condensation; pfam00668 512565015571 HIRAN domain; Region: HIRAN; pfam08797 512565015572 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 512565015573 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 512565015574 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 512565015575 calcium binding site 2 [ion binding]; other site 512565015576 active site 512565015577 catalytic triad [active] 512565015578 calcium binding site 1 [ion binding]; other site 512565015579 YhhN-like protein; Region: YhhN; cl01505 512565015580 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565015581 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 512565015582 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565015583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565015584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565015585 active site 512565015586 catalytic tetrad [active] 512565015587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565015588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565015589 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512565015590 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 512565015591 NAD binding site [chemical binding]; other site 512565015592 substrate binding site [chemical binding]; other site 512565015593 catalytic Zn binding site [ion binding]; other site 512565015594 tetramer interface [polypeptide binding]; other site 512565015595 structural Zn binding site [ion binding]; other site 512565015596 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 512565015597 Pyruvate formate lyase 1; Region: PFL1; cd01678 512565015598 coenzyme A binding site [chemical binding]; other site 512565015599 active site 512565015600 catalytic residues [active] 512565015601 glycine loop; other site 512565015602 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 512565015603 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565015604 FeS/SAM binding site; other site 512565015605 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 512565015606 lycopene cyclase; Region: lycopene_cycl; TIGR01789 512565015607 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 512565015608 Lipase (class 2); Region: Lipase_2; pfam01674 512565015609 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565015610 VanZ like family; Region: VanZ; pfam04892 512565015611 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 512565015612 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 512565015613 G1 box; other site 512565015614 putative GEF interaction site [polypeptide binding]; other site 512565015615 GTP/Mg2+ binding site [chemical binding]; other site 512565015616 Switch I region; other site 512565015617 G2 box; other site 512565015618 G3 box; other site 512565015619 Switch II region; other site 512565015620 G4 box; other site 512565015621 G5 box; other site 512565015622 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 512565015623 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 512565015624 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565015625 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 512565015626 potential protein location (hypothetical protein AMIS_59070 [Actinoplanes missouriensis 431]) that overlaps RNA (tRNA-U) 512565015627 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 512565015628 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 512565015629 dimerization interface [polypeptide binding]; other site 512565015630 putative ATP binding site [chemical binding]; other site 512565015631 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 512565015632 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565015633 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565015634 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 512565015635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565015636 dimerization interface [polypeptide binding]; other site 512565015637 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565015638 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565015639 dimer interface [polypeptide binding]; other site 512565015640 putative CheW interface [polypeptide binding]; other site 512565015641 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 512565015642 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 512565015643 4Fe-4S binding domain; Region: Fer4; pfam00037 512565015644 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565015645 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565015646 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565015647 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 512565015648 molybdopterin cofactor binding site; other site 512565015649 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 512565015650 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 512565015651 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 512565015652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565015653 NAD(P) binding site [chemical binding]; other site 512565015654 active site 512565015655 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 512565015656 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 512565015657 active site 512565015658 catalytic site [active] 512565015659 Predicted amidohydrolase [General function prediction only]; Region: COG0388 512565015660 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 512565015661 active site 512565015662 catalytic triad [active] 512565015663 dimer interface [polypeptide binding]; other site 512565015664 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 512565015665 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 512565015666 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565015667 Interdomain contacts; other site 512565015668 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565015669 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565015670 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565015671 DNA binding residues [nucleotide binding] 512565015672 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 512565015673 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 512565015674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565015675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565015676 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 512565015677 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565015678 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 512565015679 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 512565015680 conserved cys residue [active] 512565015681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565015682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565015683 NAD(P) binding site [chemical binding]; other site 512565015684 active site 512565015685 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 512565015686 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 512565015687 CBD_II domain; Region: CBD_II; smart00637 512565015688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565015689 non-specific DNA binding site [nucleotide binding]; other site 512565015690 salt bridge; other site 512565015691 sequence-specific DNA binding site [nucleotide binding]; other site 512565015692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565015693 S-adenosylmethionine binding site [chemical binding]; other site 512565015694 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 512565015695 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 512565015696 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 512565015697 active site 512565015698 dimer interface [polypeptide binding]; other site 512565015699 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565015700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565015701 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 512565015702 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565015703 active site 512565015704 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565015705 active site 512565015706 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 512565015707 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 512565015708 putative ligand binding site [chemical binding]; other site 512565015709 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565015710 dimerization interface [polypeptide binding]; other site 512565015711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565015712 putative CheW interface [polypeptide binding]; other site 512565015713 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 512565015714 RDD family; Region: RDD; pfam06271 512565015715 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565015716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565015717 DNA-binding site [nucleotide binding]; DNA binding site 512565015718 UTRA domain; Region: UTRA; pfam07702 512565015719 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 512565015720 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 512565015721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565015722 motif II; other site 512565015723 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565015724 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 512565015725 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512565015726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565015727 Walker A/P-loop; other site 512565015728 ATP binding site [chemical binding]; other site 512565015729 Q-loop/lid; other site 512565015730 ABC transporter signature motif; other site 512565015731 Walker B; other site 512565015732 D-loop; other site 512565015733 H-loop/switch region; other site 512565015734 TOBE domain; Region: TOBE_2; pfam08402 512565015735 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 512565015736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015737 dimer interface [polypeptide binding]; other site 512565015738 conserved gate region; other site 512565015739 putative PBP binding loops; other site 512565015740 ABC-ATPase subunit interface; other site 512565015741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015742 dimer interface [polypeptide binding]; other site 512565015743 conserved gate region; other site 512565015744 putative PBP binding loops; other site 512565015745 ABC-ATPase subunit interface; other site 512565015746 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565015747 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 512565015748 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565015749 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512565015750 TM-ABC transporter signature motif; other site 512565015751 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 512565015752 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 512565015753 TM-ABC transporter signature motif; other site 512565015754 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565015755 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512565015756 Walker A/P-loop; other site 512565015757 ATP binding site [chemical binding]; other site 512565015758 Q-loop/lid; other site 512565015759 ABC transporter signature motif; other site 512565015760 Walker B; other site 512565015761 D-loop; other site 512565015762 H-loop/switch region; other site 512565015763 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565015764 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512565015765 Walker A/P-loop; other site 512565015766 ATP binding site [chemical binding]; other site 512565015767 Q-loop/lid; other site 512565015768 ABC transporter signature motif; other site 512565015769 Walker B; other site 512565015770 D-loop; other site 512565015771 H-loop/switch region; other site 512565015772 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 512565015773 VanZ like family; Region: VanZ; pfam04892 512565015774 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565015775 MarR family; Region: MarR; pfam01047 512565015776 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 512565015777 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565015778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565015779 short chain dehydrogenase; Provisional; Region: PRK06197 512565015780 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 512565015781 putative NAD(P) binding site [chemical binding]; other site 512565015782 active site 512565015783 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 512565015784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565015785 S-adenosylmethionine binding site [chemical binding]; other site 512565015786 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565015787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565015788 sequence-specific DNA binding site [nucleotide binding]; other site 512565015789 salt bridge; other site 512565015790 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 512565015791 active site 512565015792 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 512565015793 POT family; Region: PTR2; cl17359 512565015794 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 512565015795 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 512565015796 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 512565015797 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 512565015798 metal binding site [ion binding]; metal-binding site 512565015799 substrate binding pocket [chemical binding]; other site 512565015800 Class I aldolases; Region: Aldolase_Class_I; cl17187 512565015801 catalytic residue [active] 512565015802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565015803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015804 dimer interface [polypeptide binding]; other site 512565015805 conserved gate region; other site 512565015806 putative PBP binding loops; other site 512565015807 ABC-ATPase subunit interface; other site 512565015808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565015809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015810 ABC-ATPase subunit interface; other site 512565015811 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565015812 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565015813 extended (e) SDRs; Region: SDR_e; cd08946 512565015814 NAD(P) binding site [chemical binding]; other site 512565015815 active site 512565015816 substrate binding site [chemical binding]; other site 512565015817 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 512565015818 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 512565015819 dimer interface [polypeptide binding]; other site 512565015820 NADP binding site [chemical binding]; other site 512565015821 catalytic residues [active] 512565015822 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565015823 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 512565015824 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565015825 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 512565015826 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 512565015827 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 512565015828 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 512565015829 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565015830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015831 dimer interface [polypeptide binding]; other site 512565015832 conserved gate region; other site 512565015833 putative PBP binding loops; other site 512565015834 ABC-ATPase subunit interface; other site 512565015835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565015836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565015837 dimer interface [polypeptide binding]; other site 512565015838 conserved gate region; other site 512565015839 putative PBP binding loops; other site 512565015840 ABC-ATPase subunit interface; other site 512565015841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565015842 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565015843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565015844 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565015845 ligand binding site [chemical binding]; other site 512565015846 dimerization interface [polypeptide binding]; other site 512565015847 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 512565015848 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565015849 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565015850 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 512565015851 DNA binding residues [nucleotide binding] 512565015852 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565015853 drug binding residues [chemical binding]; other site 512565015854 dimer interface [polypeptide binding]; other site 512565015855 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 512565015856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565015857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 512565015858 active site 512565015859 metal binding site [ion binding]; metal-binding site 512565015860 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565015861 anti sigma factor interaction site; other site 512565015862 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565015863 regulatory phosphorylation site [posttranslational modification]; other site 512565015864 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565015865 tetracycline repressor protein TetR; Provisional; Region: PRK13756 512565015866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565015867 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565015868 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565015869 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 512565015870 putative NAD(P) binding site [chemical binding]; other site 512565015871 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 512565015872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565015873 FeS/SAM binding site; other site 512565015874 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 512565015875 Transglycosylase; Region: Transgly; pfam00912 512565015876 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 512565015877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512565015878 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565015879 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 512565015880 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 512565015881 G1 box; other site 512565015882 putative GEF interaction site [polypeptide binding]; other site 512565015883 GTP/Mg2+ binding site [chemical binding]; other site 512565015884 Switch I region; other site 512565015885 G2 box; other site 512565015886 G3 box; other site 512565015887 Switch II region; other site 512565015888 G4 box; other site 512565015889 G5 box; other site 512565015890 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 512565015891 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 512565015892 Peptidase family M1; Region: Peptidase_M1; pfam01433 512565015893 Zn binding site [ion binding]; other site 512565015894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565015895 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 512565015896 acyl-activating enzyme (AAE) consensus motif; other site 512565015897 AMP binding site [chemical binding]; other site 512565015898 active site 512565015899 CoA binding site [chemical binding]; other site 512565015900 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565015901 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 512565015902 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 512565015903 putative trimer interface [polypeptide binding]; other site 512565015904 putative CoA binding site [chemical binding]; other site 512565015905 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 512565015906 putative trimer interface [polypeptide binding]; other site 512565015907 putative CoA binding site [chemical binding]; other site 512565015908 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 512565015909 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 512565015910 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 512565015911 active site 512565015912 catalytic site [active] 512565015913 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565015914 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565015915 putative sugar binding sites [chemical binding]; other site 512565015916 Q-X-W motif; other site 512565015917 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 512565015918 chitosan binding site [chemical binding]; other site 512565015919 catalytic residues [active] 512565015920 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 512565015921 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 512565015922 N- and C-terminal domain interface [polypeptide binding]; other site 512565015923 active site 512565015924 catalytic site [active] 512565015925 metal binding site [ion binding]; metal-binding site 512565015926 carbohydrate binding site [chemical binding]; other site 512565015927 ATP binding site [chemical binding]; other site 512565015928 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 512565015929 AAA domain; Region: AAA_11; pfam13086 512565015930 AAA domain; Region: AAA_12; pfam13087 512565015931 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 512565015932 Part of AAA domain; Region: AAA_19; pfam13245 512565015933 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565015934 AAA domain; Region: AAA_12; pfam13087 512565015935 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565015936 putative active site [active] 512565015937 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 512565015938 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512565015939 Family description; Region: UvrD_C_2; pfam13538 512565015940 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565015941 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565015942 active site 512565015943 ATP binding site [chemical binding]; other site 512565015944 substrate binding site [chemical binding]; other site 512565015945 activation loop (A-loop); other site 512565015946 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512565015947 Family description; Region: UvrD_C_2; pfam13538 512565015948 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 512565015949 DEAD/DEAH box helicase; Region: DEAD; pfam00270 512565015950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565015951 ATP-binding site [chemical binding]; other site 512565015952 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 512565015953 50S ribosomal protein L12P; Reviewed; Region: rpl12p; PRK06402 512565015954 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512565015955 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565015956 ATP binding site [chemical binding]; other site 512565015957 putative Mg++ binding site [ion binding]; other site 512565015958 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 512565015959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565015960 nucleotide binding region [chemical binding]; other site 512565015961 ATP-binding site [chemical binding]; other site 512565015962 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565015963 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565015964 active site 512565015965 ATP binding site [chemical binding]; other site 512565015966 substrate binding site [chemical binding]; other site 512565015967 activation loop (A-loop); other site 512565015968 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 512565015969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565015970 S-adenosylmethionine binding site [chemical binding]; other site 512565015971 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 512565015972 YCII-related domain; Region: YCII; cl00999 512565015973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565015974 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565015975 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565015976 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 512565015977 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 512565015978 G1 box; other site 512565015979 GTP/Mg2+ binding site [chemical binding]; other site 512565015980 Switch I region; other site 512565015981 G2 box; other site 512565015982 Switch II region; other site 512565015983 G3 box; other site 512565015984 G4 box; other site 512565015985 G5 box; other site 512565015986 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 512565015987 G1 box; other site 512565015988 GTP/Mg2+ binding site [chemical binding]; other site 512565015989 Switch I region; other site 512565015990 G2 box; other site 512565015991 G3 box; other site 512565015992 Switch II region; other site 512565015993 G4 box; other site 512565015994 G5 box; other site 512565015995 cytidylate kinase; Provisional; Region: cmk; PRK00023 512565015996 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 512565015997 CMP-binding site; other site 512565015998 The sites determining sugar specificity; other site 512565015999 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565016000 MarR family; Region: MarR_2; pfam12802 512565016001 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 512565016002 catalytic motif [active] 512565016003 Zn binding site [ion binding]; other site 512565016004 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 512565016005 dimerization interface [polypeptide binding]; other site 512565016006 active site 512565016007 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 512565016008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565016009 putative substrate translocation pore; other site 512565016010 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 512565016011 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 512565016012 protein-splicing catalytic site; other site 512565016013 thioester formation/cholesterol transfer; other site 512565016014 Pretoxin HINT domain; Region: PT-HINT; pfam07591 512565016015 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 512565016016 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565016017 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565016018 putative sugar binding sites [chemical binding]; other site 512565016019 Q-X-W motif; other site 512565016020 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 512565016021 dimerization interface [polypeptide binding]; other site 512565016022 mannose binding site [chemical binding]; other site 512565016023 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565016024 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565016025 putative sugar binding sites [chemical binding]; other site 512565016026 Q-X-W motif; other site 512565016027 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 512565016028 Predicted transcriptional regulator [Transcription]; Region: COG3655 512565016029 sequence-specific DNA binding site [nucleotide binding]; other site 512565016030 salt bridge; other site 512565016031 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565016032 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565016033 Glyco_18 domain; Region: Glyco_18; smart00636 512565016034 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 512565016035 active site 512565016036 Ricin-type beta-trefoil; Region: RICIN; smart00458 512565016037 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565016038 putative sugar binding sites [chemical binding]; other site 512565016039 Q-X-W motif; other site 512565016040 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 512565016041 putative active site [active] 512565016042 Zn binding site [ion binding]; other site 512565016043 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565016044 Phosphotransferase enzyme family; Region: APH; pfam01636 512565016045 active site 512565016046 substrate binding site [chemical binding]; other site 512565016047 ATP binding site [chemical binding]; other site 512565016048 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 512565016049 cleavage site 512565016050 active site 512565016051 substrate binding sites [chemical binding]; other site 512565016052 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 512565016053 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 512565016054 acyl-activating enzyme (AAE) consensus motif; other site 512565016055 putative AMP binding site [chemical binding]; other site 512565016056 putative active site [active] 512565016057 putative CoA binding site [chemical binding]; other site 512565016058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565016059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565016060 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 512565016061 catalytic site [active] 512565016062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565016063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565016064 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 512565016065 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565016066 dimer interface [polypeptide binding]; other site 512565016067 active site 512565016068 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 512565016069 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565016070 substrate binding site [chemical binding]; other site 512565016071 oxyanion hole (OAH) forming residues; other site 512565016072 trimer interface [polypeptide binding]; other site 512565016073 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 512565016074 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 512565016075 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 512565016076 Phosphotransferase enzyme family; Region: APH; pfam01636 512565016077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512565016078 active site 512565016079 ATP binding site [chemical binding]; other site 512565016080 substrate binding site [chemical binding]; other site 512565016081 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565016082 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565016083 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565016084 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565016085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565016086 Walker A/P-loop; other site 512565016087 ATP binding site [chemical binding]; other site 512565016088 Q-loop/lid; other site 512565016089 ABC transporter signature motif; other site 512565016090 Walker B; other site 512565016091 D-loop; other site 512565016092 H-loop/switch region; other site 512565016093 acyl-CoA synthetase; Validated; Region: PRK07787 512565016094 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565016095 acyl-activating enzyme (AAE) consensus motif; other site 512565016096 AMP binding site [chemical binding]; other site 512565016097 active site 512565016098 CoA binding site [chemical binding]; other site 512565016099 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565016100 metal binding site [ion binding]; metal-binding site 512565016101 active site 512565016102 I-site; other site 512565016103 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565016104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 512565016105 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565016106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565016107 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 512565016108 putative dimerization interface [polypeptide binding]; other site 512565016109 Flavoprotein; Region: Flavoprotein; pfam02441 512565016110 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 512565016111 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512565016112 RNA binding surface [nucleotide binding]; other site 512565016113 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 512565016114 active site 512565016115 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 512565016116 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 512565016117 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565016118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565016119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565016120 S-adenosylmethionine binding site [chemical binding]; other site 512565016121 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 512565016122 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 512565016123 P-loop; other site 512565016124 Magnesium ion binding site [ion binding]; other site 512565016125 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 512565016126 Magnesium ion binding site [ion binding]; other site 512565016127 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 512565016128 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565016129 active site 512565016130 DNA binding site [nucleotide binding] 512565016131 Int/Topo IB signature motif; other site 512565016132 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 512565016133 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 512565016134 hexamer interface [polypeptide binding]; other site 512565016135 ligand binding site [chemical binding]; other site 512565016136 putative active site [active] 512565016137 NAD(P) binding site [chemical binding]; other site 512565016138 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 512565016139 RNAase interaction site [polypeptide binding]; other site 512565016140 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565016141 active site 512565016142 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565016143 CAAX protease self-immunity; Region: Abi; pfam02517 512565016144 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 512565016145 dimer interface [polypeptide binding]; other site 512565016146 active site 512565016147 ADP-ribose binding site [chemical binding]; other site 512565016148 nudix motif; other site 512565016149 metal binding site [ion binding]; metal-binding site 512565016150 CTP synthetase; Validated; Region: pyrG; PRK05380 512565016151 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 512565016152 Catalytic site [active] 512565016153 active site 512565016154 UTP binding site [chemical binding]; other site 512565016155 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 512565016156 active site 512565016157 putative oxyanion hole; other site 512565016158 catalytic triad [active] 512565016159 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565016160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565016161 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 512565016162 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 512565016163 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 512565016164 Thiamine pyrophosphokinase; Region: TPK; cl08415 512565016165 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 512565016166 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 512565016167 Walker A/P-loop; other site 512565016168 ATP binding site [chemical binding]; other site 512565016169 Q-loop/lid; other site 512565016170 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 512565016171 ABC transporter signature motif; other site 512565016172 Walker B; other site 512565016173 D-loop; other site 512565016174 H-loop/switch region; other site 512565016175 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 512565016176 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 512565016177 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 512565016178 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512565016179 RNA binding surface [nucleotide binding]; other site 512565016180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565016181 S-adenosylmethionine binding site [chemical binding]; other site 512565016182 Uncharacterized conserved protein [Function unknown]; Region: COG3937 512565016183 SCP-2 sterol transfer family; Region: SCP2; pfam02036 512565016184 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565016185 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565016186 dimer interface [polypeptide binding]; other site 512565016187 putative CheW interface [polypeptide binding]; other site 512565016188 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 512565016189 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565016190 active site 512565016191 motif I; other site 512565016192 motif II; other site 512565016193 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 512565016194 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 512565016195 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 512565016196 active site 512565016197 HIGH motif; other site 512565016198 dimer interface [polypeptide binding]; other site 512565016199 KMSKS motif; other site 512565016200 S4 RNA-binding domain; Region: S4; smart00363 512565016201 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 512565016202 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 512565016203 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 512565016204 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 512565016205 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 512565016206 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 512565016207 dimerization domain swap beta strand [polypeptide binding]; other site 512565016208 regulatory protein interface [polypeptide binding]; other site 512565016209 active site 512565016210 regulatory phosphorylation site [posttranslational modification]; other site 512565016211 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512565016212 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 512565016213 putative NAD(P) binding site [chemical binding]; other site 512565016214 catalytic Zn binding site [ion binding]; other site 512565016215 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512565016216 active site 512565016217 phosphorylation site [posttranslational modification] 512565016218 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 512565016219 active site 512565016220 P-loop; other site 512565016221 phosphorylation site [posttranslational modification] 512565016222 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 512565016223 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 512565016224 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 512565016225 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 512565016226 putative substrate binding site [chemical binding]; other site 512565016227 putative ATP binding site [chemical binding]; other site 512565016228 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512565016229 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 512565016230 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512565016231 adenylate kinase; Reviewed; Region: adk; PRK00279 512565016232 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 512565016233 AMP-binding site [chemical binding]; other site 512565016234 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 512565016235 PemK-like protein; Region: PemK; pfam02452 512565016236 agmatinase; Region: agmatinase; TIGR01230 512565016237 Agmatinase-like family; Region: Agmatinase-like; cd09990 512565016238 active site 512565016239 oligomer interface [polypeptide binding]; other site 512565016240 Mn binding site [ion binding]; other site 512565016241 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 512565016242 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565016243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565016244 non-specific DNA binding site [nucleotide binding]; other site 512565016245 salt bridge; other site 512565016246 sequence-specific DNA binding site [nucleotide binding]; other site 512565016247 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 512565016248 active site 512565016249 DNA binding site [nucleotide binding] 512565016250 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512565016251 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 512565016252 Family description; Region: UvrD_C_2; pfam13538 512565016253 FOG: CBS domain [General function prediction only]; Region: COG0517 512565016254 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 512565016255 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565016256 substrate binding site [chemical binding]; other site 512565016257 ATP binding site [chemical binding]; other site 512565016258 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565016259 catalytic core [active] 512565016260 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512565016261 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 512565016262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565016263 dimerization interface [polypeptide binding]; other site 512565016264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565016265 PAS domain; Region: PAS_9; pfam13426 512565016266 putative active site [active] 512565016267 heme pocket [chemical binding]; other site 512565016268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565016269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565016270 metal binding site [ion binding]; metal-binding site 512565016271 active site 512565016272 I-site; other site 512565016273 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565016274 DinB superfamily; Region: DinB_2; pfam12867 512565016275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565016276 DNA-binding site [nucleotide binding]; DNA binding site 512565016277 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 512565016278 FCD domain; Region: FCD; pfam07729 512565016279 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 512565016280 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 512565016281 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565016282 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 512565016283 active site 512565016284 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 512565016285 active site 512565016286 catalytic site [active] 512565016287 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 512565016288 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512565016289 carbohydrate binding site [chemical binding]; other site 512565016290 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512565016291 carbohydrate binding site [chemical binding]; other site 512565016292 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 512565016293 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 512565016294 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 512565016295 Ca binding site [ion binding]; other site 512565016296 active site 512565016297 catalytic site [active] 512565016298 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 512565016299 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 512565016300 maltodextrin glucosidase; Provisional; Region: PRK10785 512565016301 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 512565016302 active site 512565016303 homodimer interface [polypeptide binding]; other site 512565016304 catalytic site [active] 512565016305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565016306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565016307 dimer interface [polypeptide binding]; other site 512565016308 conserved gate region; other site 512565016309 putative PBP binding loops; other site 512565016310 ABC-ATPase subunit interface; other site 512565016311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565016312 dimer interface [polypeptide binding]; other site 512565016313 conserved gate region; other site 512565016314 ABC-ATPase subunit interface; other site 512565016315 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 512565016316 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565016317 potential frameshift: common BLAST hit: gi|159036403|ref|YP_001535656.1| LacI family transcriptional regulator 512565016318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565016319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565016320 DNA binding site [nucleotide binding] 512565016321 domain linker motif; other site 512565016322 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565016323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565016324 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565016325 argininosuccinate lyase; Provisional; Region: PRK00855 512565016326 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 512565016327 active sites [active] 512565016328 tetramer interface [polypeptide binding]; other site 512565016329 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 512565016330 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 512565016331 metal binding site [ion binding]; metal-binding site 512565016332 putative dimer interface [polypeptide binding]; other site 512565016333 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 512565016334 Ligand Binding Site [chemical binding]; other site 512565016335 arginine repressor; Provisional; Region: PRK03341 512565016336 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 512565016337 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 512565016338 ornithine carbamoyltransferase; Provisional; Region: PRK00779 512565016339 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 512565016340 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 512565016341 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 512565016342 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565016343 inhibitor-cofactor binding pocket; inhibition site 512565016344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565016345 catalytic residue [active] 512565016346 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 512565016347 feedback inhibition sensing region; other site 512565016348 homohexameric interface [polypeptide binding]; other site 512565016349 nucleotide binding site [chemical binding]; other site 512565016350 N-acetyl-L-glutamate binding site [chemical binding]; other site 512565016351 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 512565016352 heterotetramer interface [polypeptide binding]; other site 512565016353 active site pocket [active] 512565016354 cleavage site 512565016355 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 512565016356 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 512565016357 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 512565016358 putative active site [active] 512565016359 Predicted acetyltransferase [General function prediction only]; Region: COG3393 512565016360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565016361 S-adenosylmethionine binding site [chemical binding]; other site 512565016362 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565016363 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565016364 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 512565016365 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 512565016366 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 512565016367 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565016368 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 512565016369 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 512565016370 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 512565016371 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 512565016372 putative active site [active] 512565016373 putative dimer interface [polypeptide binding]; other site 512565016374 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 512565016375 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 512565016376 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 512565016377 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 512565016378 metal ion-dependent adhesion site (MIDAS); other site 512565016379 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565016380 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 512565016381 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 512565016382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565016383 Coenzyme A binding pocket [chemical binding]; other site 512565016384 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 512565016385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565016386 NAD(P) binding site [chemical binding]; other site 512565016387 active site 512565016388 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 512565016389 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 512565016390 putative dimer interface [polypeptide binding]; other site 512565016391 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512565016392 metal binding site [ion binding]; metal-binding site 512565016393 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565016394 Interdomain contacts; other site 512565016395 Cytokine receptor motif; other site 512565016396 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 512565016397 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 512565016398 putative tRNA-binding site [nucleotide binding]; other site 512565016399 B3/4 domain; Region: B3_4; pfam03483 512565016400 tRNA synthetase B5 domain; Region: B5; smart00874 512565016401 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 512565016402 dimer interface [polypeptide binding]; other site 512565016403 motif 1; other site 512565016404 motif 3; other site 512565016405 motif 2; other site 512565016406 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 512565016407 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 512565016408 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 512565016409 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 512565016410 dimer interface [polypeptide binding]; other site 512565016411 motif 1; other site 512565016412 active site 512565016413 motif 2; other site 512565016414 motif 3; other site 512565016415 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 512565016416 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 512565016417 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512565016418 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 512565016419 23S rRNA binding site [nucleotide binding]; other site 512565016420 L21 binding site [polypeptide binding]; other site 512565016421 L13 binding site [polypeptide binding]; other site 512565016422 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 512565016423 translation initiation factor IF-3; Region: infC; TIGR00168 512565016424 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 512565016425 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 512565016426 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 512565016427 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 512565016428 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 512565016429 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 512565016430 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 512565016431 homodimer interface [polypeptide binding]; other site 512565016432 putative metal binding site [ion binding]; other site 512565016433 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565016434 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512565016435 substrate binding pocket [chemical binding]; other site 512565016436 membrane-bound complex binding site; other site 512565016437 hinge residues; other site 512565016438 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 512565016439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565016440 dimer interface [polypeptide binding]; other site 512565016441 conserved gate region; other site 512565016442 putative PBP binding loops; other site 512565016443 ABC-ATPase subunit interface; other site 512565016444 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512565016445 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512565016446 Walker A/P-loop; other site 512565016447 ATP binding site [chemical binding]; other site 512565016448 Q-loop/lid; other site 512565016449 ABC transporter signature motif; other site 512565016450 Walker B; other site 512565016451 D-loop; other site 512565016452 H-loop/switch region; other site 512565016453 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 512565016454 homopentamer interface [polypeptide binding]; other site 512565016455 active site 512565016456 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 512565016457 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 512565016458 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 512565016459 dimerization interface [polypeptide binding]; other site 512565016460 active site 512565016461 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 512565016462 Lumazine binding domain; Region: Lum_binding; pfam00677 512565016463 Lumazine binding domain; Region: Lum_binding; pfam00677 512565016464 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 512565016465 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 512565016466 catalytic motif [active] 512565016467 Zn binding site [ion binding]; other site 512565016468 RibD C-terminal domain; Region: RibD_C; cl17279 512565016469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565016470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565016471 WHG domain; Region: WHG; pfam13305 512565016472 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565016473 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565016474 putative acyl-acceptor binding pocket; other site 512565016475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565016476 active site 512565016477 phosphorylation site [posttranslational modification] 512565016478 intermolecular recognition site; other site 512565016479 dimerization interface [polypeptide binding]; other site 512565016480 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565016481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565016482 metal binding site [ion binding]; metal-binding site 512565016483 active site 512565016484 I-site; other site 512565016485 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 512565016486 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 512565016487 substrate binding site [chemical binding]; other site 512565016488 hexamer interface [polypeptide binding]; other site 512565016489 metal binding site [ion binding]; metal-binding site 512565016490 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512565016491 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 512565016492 16S rRNA methyltransferase B; Provisional; Region: PRK14902 512565016493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565016494 S-adenosylmethionine binding site [chemical binding]; other site 512565016495 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 512565016496 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 512565016497 putative active site [active] 512565016498 substrate binding site [chemical binding]; other site 512565016499 putative cosubstrate binding site; other site 512565016500 catalytic site [active] 512565016501 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 512565016502 substrate binding site [chemical binding]; other site 512565016503 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 512565016504 active site 512565016505 catalytic residues [active] 512565016506 metal binding site [ion binding]; metal-binding site 512565016507 primosome assembly protein PriA; Provisional; Region: PRK14873 512565016508 S-adenosylmethionine synthetase; Validated; Region: PRK05250 512565016509 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 512565016510 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 512565016511 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 512565016512 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 512565016513 Flavoprotein; Region: Flavoprotein; pfam02441 512565016514 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 512565016515 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 512565016516 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 512565016517 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 512565016518 catalytic site [active] 512565016519 G-X2-G-X-G-K; other site 512565016520 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 512565016521 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 512565016522 active site 512565016523 dimer interface [polypeptide binding]; other site 512565016524 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 512565016525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565016526 inhibitor-cofactor binding pocket; inhibition site 512565016527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565016528 catalytic residue [active] 512565016529 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 512565016530 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 512565016531 quinone interaction residues [chemical binding]; other site 512565016532 active site 512565016533 catalytic residues [active] 512565016534 FMN binding site [chemical binding]; other site 512565016535 substrate binding site [chemical binding]; other site 512565016536 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 512565016537 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512565016538 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 512565016539 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 512565016540 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512565016541 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565016542 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 512565016543 IMP binding site; other site 512565016544 dimer interface [polypeptide binding]; other site 512565016545 interdomain contacts; other site 512565016546 partial ornithine binding site; other site 512565016547 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 512565016548 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 512565016549 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 512565016550 catalytic site [active] 512565016551 subunit interface [polypeptide binding]; other site 512565016552 dihydroorotase; Validated; Region: pyrC; PRK09357 512565016553 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 512565016554 active site 512565016555 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 512565016556 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 512565016557 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 512565016558 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 512565016559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565016560 active site 512565016561 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565016562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565016563 non-specific DNA binding site [nucleotide binding]; other site 512565016564 salt bridge; other site 512565016565 sequence-specific DNA binding site [nucleotide binding]; other site 512565016566 transcription antitermination factor NusB; Region: nusB; TIGR01951 512565016567 elongation factor P; Validated; Region: PRK00529 512565016568 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 512565016569 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 512565016570 RNA binding site [nucleotide binding]; other site 512565016571 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 512565016572 RNA binding site [nucleotide binding]; other site 512565016573 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 512565016574 Dehydroquinase class II; Region: DHquinase_II; pfam01220 512565016575 active site 512565016576 trimer interface [polypeptide binding]; other site 512565016577 dimer interface [polypeptide binding]; other site 512565016578 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 512565016579 dimer interface [polypeptide binding]; other site 512565016580 active site 512565016581 metal binding site [ion binding]; metal-binding site 512565016582 Clp amino terminal domain; Region: Clp_N; pfam02861 512565016583 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565016584 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565016585 NodB motif; other site 512565016586 active site 512565016587 catalytic site [active] 512565016588 metal binding site [ion binding]; metal-binding site 512565016589 shikimate kinase; Reviewed; Region: aroK; PRK00131 512565016590 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 512565016591 ADP binding site [chemical binding]; other site 512565016592 magnesium binding site [ion binding]; other site 512565016593 putative shikimate binding site; other site 512565016594 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 512565016595 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 512565016596 Tetramer interface [polypeptide binding]; other site 512565016597 active site 512565016598 FMN-binding site [chemical binding]; other site 512565016599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565016600 putative substrate translocation pore; other site 512565016601 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 512565016602 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 512565016603 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 512565016604 shikimate binding site; other site 512565016605 NAD(P) binding site [chemical binding]; other site 512565016606 YceG-like family; Region: YceG; pfam02618 512565016607 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 512565016608 dimerization interface [polypeptide binding]; other site 512565016609 YceG-like family; Region: YceG; pfam02618 512565016610 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 512565016611 dimerization interface [polypeptide binding]; other site 512565016612 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 512565016613 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 512565016614 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 512565016615 motif 1; other site 512565016616 active site 512565016617 motif 2; other site 512565016618 motif 3; other site 512565016619 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 512565016620 recombination factor protein RarA; Reviewed; Region: PRK13342 512565016621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565016622 Walker A motif; other site 512565016623 ATP binding site [chemical binding]; other site 512565016624 Walker B motif; other site 512565016625 arginine finger; other site 512565016626 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 512565016627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565016628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565016629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565016630 dimerization interface [polypeptide binding]; other site 512565016631 putative DNA binding site [nucleotide binding]; other site 512565016632 putative Zn2+ binding site [ion binding]; other site 512565016633 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 512565016634 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 512565016635 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 512565016636 dimer interface [polypeptide binding]; other site 512565016637 anticodon binding site; other site 512565016638 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 512565016639 homodimer interface [polypeptide binding]; other site 512565016640 motif 1; other site 512565016641 active site 512565016642 motif 2; other site 512565016643 GAD domain; Region: GAD; pfam02938 512565016644 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 512565016645 motif 3; other site 512565016646 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 512565016647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 512565016648 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 512565016649 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565016650 catalytic residue [active] 512565016651 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 512565016652 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 512565016653 active site 512565016654 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565016655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565016656 dimer interface [polypeptide binding]; other site 512565016657 conserved gate region; other site 512565016658 putative PBP binding loops; other site 512565016659 ABC-ATPase subunit interface; other site 512565016660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512565016661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565016662 putative PBP binding loops; other site 512565016663 ABC-ATPase subunit interface; other site 512565016664 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565016665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565016666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 512565016667 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 512565016668 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565016669 active site 512565016670 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512565016671 homotrimer interaction site [polypeptide binding]; other site 512565016672 putative active site [active] 512565016673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565016674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565016675 active site 512565016676 ATP binding site [chemical binding]; other site 512565016677 substrate binding site [chemical binding]; other site 512565016678 activation loop (A-loop); other site 512565016679 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512565016680 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 512565016681 alpha-gamma subunit interface [polypeptide binding]; other site 512565016682 beta-gamma subunit interface [polypeptide binding]; other site 512565016683 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 512565016684 alpha-beta subunit interface [polypeptide binding]; other site 512565016685 urease subunit alpha; Reviewed; Region: ureC; PRK13206 512565016686 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 512565016687 subunit interactions [polypeptide binding]; other site 512565016688 active site 512565016689 flap region; other site 512565016690 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 512565016691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565016692 UreD urease accessory protein; Region: UreD; cl00530 512565016693 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 512565016694 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565016695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565016696 DNA binding residues [nucleotide binding] 512565016697 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565016698 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565016699 active site 512565016700 ATP binding site [chemical binding]; other site 512565016701 substrate binding site [chemical binding]; other site 512565016702 activation loop (A-loop); other site 512565016703 cyanophycin synthetase; Provisional; Region: PRK14016 512565016704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565016705 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512565016706 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512565016707 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 512565016708 proposed catalytic triad [active] 512565016709 active site nucleophile [active] 512565016710 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 512565016711 CoenzymeA binding site [chemical binding]; other site 512565016712 subunit interaction site [polypeptide binding]; other site 512565016713 PHB binding site; other site 512565016714 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565016715 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 512565016716 Transmembrane secretion effector; Region: MFS_3; pfam05977 512565016717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565016718 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 512565016719 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 512565016720 dimer interface [polypeptide binding]; other site 512565016721 motif 1; other site 512565016722 active site 512565016723 motif 2; other site 512565016724 motif 3; other site 512565016725 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 512565016726 anticodon binding site; other site 512565016727 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 512565016728 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 512565016729 active site 512565016730 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 512565016731 active site 512565016732 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 512565016733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565016734 Zn2+ binding site [ion binding]; other site 512565016735 Mg2+ binding site [ion binding]; other site 512565016736 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 512565016737 synthetase active site [active] 512565016738 NTP binding site [chemical binding]; other site 512565016739 metal binding site [ion binding]; metal-binding site 512565016740 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 512565016741 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 512565016742 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565016743 active site 512565016744 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 512565016745 Protein export membrane protein; Region: SecD_SecF; cl14618 512565016746 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 512565016747 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 512565016748 Preprotein translocase subunit; Region: YajC; pfam02699 512565016749 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 512565016750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565016751 Walker A motif; other site 512565016752 ATP binding site [chemical binding]; other site 512565016753 Walker B motif; other site 512565016754 arginine finger; other site 512565016755 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 512565016756 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 512565016757 RuvA N terminal domain; Region: RuvA_N; pfam01330 512565016758 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 512565016759 active site 512565016760 putative DNA-binding cleft [nucleotide binding]; other site 512565016761 dimer interface [polypeptide binding]; other site 512565016762 hypothetical protein; Validated; Region: PRK00110 512565016763 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 512565016764 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 512565016765 predicted active site [active] 512565016766 catalytic triad [active] 512565016767 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 512565016768 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 512565016769 active site 512565016770 multimer interface [polypeptide binding]; other site 512565016771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565016772 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565016773 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 512565016774 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 512565016775 putative acyl-acceptor binding pocket; other site 512565016776 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 512565016777 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565016778 elongation factor G; Reviewed; Region: PRK12740 512565016779 G1 box; other site 512565016780 GTP/Mg2+ binding site [chemical binding]; other site 512565016781 G2 box; other site 512565016782 Switch I region; other site 512565016783 G3 box; other site 512565016784 Switch II region; other site 512565016785 G4 box; other site 512565016786 G5 box; other site 512565016787 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 512565016788 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 512565016789 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 512565016790 hypothetical protein; Provisional; Region: PRK07236 512565016791 hypothetical protein; Provisional; Region: PRK07588 512565016792 hypothetical protein; Provisional; Region: PRK07236 512565016793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565016794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565016795 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 512565016796 nucleotide binding site/active site [active] 512565016797 HIT family signature motif; other site 512565016798 catalytic residue [active] 512565016799 GAF domain; Region: GAF_3; pfam13492 512565016800 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565016801 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565016802 metal binding site [ion binding]; metal-binding site 512565016803 active site 512565016804 I-site; other site 512565016805 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 512565016806 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 512565016807 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 512565016808 active site 512565016809 dimer interface [polypeptide binding]; other site 512565016810 motif 1; other site 512565016811 motif 2; other site 512565016812 motif 3; other site 512565016813 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 512565016814 anticodon binding site; other site 512565016815 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 512565016816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565016817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565016818 active site 512565016819 phosphorylation site [posttranslational modification] 512565016820 intermolecular recognition site; other site 512565016821 dimerization interface [polypeptide binding]; other site 512565016822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565016823 DNA binding site [nucleotide binding] 512565016824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565016825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565016826 dimerization interface [polypeptide binding]; other site 512565016827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565016828 dimer interface [polypeptide binding]; other site 512565016829 phosphorylation site [posttranslational modification] 512565016830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565016831 ATP binding site [chemical binding]; other site 512565016832 Mg2+ binding site [ion binding]; other site 512565016833 G-X-G motif; other site 512565016834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565016835 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 512565016836 adenosine deaminase; Provisional; Region: PRK09358 512565016837 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 512565016838 active site 512565016839 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 512565016840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565016841 S-adenosylmethionine binding site [chemical binding]; other site 512565016842 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565016843 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565016844 active site 512565016845 catalytic tetrad [active] 512565016846 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 512565016847 DNA-binding site [nucleotide binding]; DNA binding site 512565016848 RNA-binding motif; other site 512565016849 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 512565016850 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 512565016851 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 512565016852 Mechanosensitive ion channel; Region: MS_channel; pfam00924 512565016853 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 512565016854 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 512565016855 Predicted acetyltransferase [General function prediction only]; Region: COG2388 512565016856 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565016857 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 512565016858 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565016859 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 512565016860 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 512565016861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565016862 ATP binding site [chemical binding]; other site 512565016863 putative Mg++ binding site [ion binding]; other site 512565016864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565016865 nucleotide binding region [chemical binding]; other site 512565016866 ATP-binding site [chemical binding]; other site 512565016867 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 512565016868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565016869 FeS/SAM binding site; other site 512565016870 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 512565016871 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 512565016872 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 512565016873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565016874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565016875 DNA binding site [nucleotide binding] 512565016876 domain linker motif; other site 512565016877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565016878 dimerization interface [polypeptide binding]; other site 512565016879 ligand binding site [chemical binding]; other site 512565016880 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 512565016881 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 512565016882 putative ligand binding site [chemical binding]; other site 512565016883 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512565016884 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565016885 TM-ABC transporter signature motif; other site 512565016886 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 512565016887 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 512565016888 TM-ABC transporter signature motif; other site 512565016889 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565016890 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512565016891 Walker A/P-loop; other site 512565016892 ATP binding site [chemical binding]; other site 512565016893 Q-loop/lid; other site 512565016894 ABC transporter signature motif; other site 512565016895 Walker B; other site 512565016896 D-loop; other site 512565016897 H-loop/switch region; other site 512565016898 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565016899 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512565016900 Walker A/P-loop; other site 512565016901 ATP binding site [chemical binding]; other site 512565016902 Q-loop/lid; other site 512565016903 ABC transporter signature motif; other site 512565016904 Walker B; other site 512565016905 D-loop; other site 512565016906 H-loop/switch region; other site 512565016907 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 512565016908 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 512565016909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565016910 AAA ATPase domain; Region: AAA_16; pfam13191 512565016911 AAA domain; Region: AAA_22; pfam13401 512565016912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565016913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565016914 DNA binding residues [nucleotide binding] 512565016915 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512565016916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565016917 S-adenosylmethionine binding site [chemical binding]; other site 512565016918 hypothetical protein; Provisional; Region: PRK07236 512565016919 hypothetical protein; Provisional; Region: PRK06753 512565016920 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565016921 Helix-turn-helix domain; Region: HTH_18; pfam12833 512565016922 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565016923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 512565016924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565016925 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 512565016926 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565016927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565016928 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565016929 DNA binding residues [nucleotide binding] 512565016930 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565016931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565016932 active site 512565016933 phosphorylation site [posttranslational modification] 512565016934 intermolecular recognition site; other site 512565016935 dimerization interface [polypeptide binding]; other site 512565016936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565016937 DNA binding residues [nucleotide binding] 512565016938 dimerization interface [polypeptide binding]; other site 512565016939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565016940 Histidine kinase; Region: HisKA_3; pfam07730 512565016941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565016942 ATP binding site [chemical binding]; other site 512565016943 Mg2+ binding site [ion binding]; other site 512565016944 G-X-G motif; other site 512565016945 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565016946 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565016947 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565016948 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565016949 Walker A/P-loop; other site 512565016950 ATP binding site [chemical binding]; other site 512565016951 Q-loop/lid; other site 512565016952 ABC transporter signature motif; other site 512565016953 Walker B; other site 512565016954 D-loop; other site 512565016955 H-loop/switch region; other site 512565016956 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 512565016957 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 512565016958 putative ADP-binding pocket [chemical binding]; other site 512565016959 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 512565016960 hydrophobic ligand binding site; other site 512565016961 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 512565016962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565016963 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565016964 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 512565016965 putative hydrophobic ligand binding site [chemical binding]; other site 512565016966 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565016967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565016968 non-specific DNA binding site [nucleotide binding]; other site 512565016969 salt bridge; other site 512565016970 sequence-specific DNA binding site [nucleotide binding]; other site 512565016971 Conserved TM helix; Region: TM_helix; pfam05552 512565016972 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 512565016973 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565016974 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565016975 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565016976 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 512565016977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565016978 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 512565016979 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 512565016980 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 512565016981 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 512565016982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 512565016983 Clp amino terminal domain; Region: Clp_N; pfam02861 512565016984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512565016985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565016986 Coenzyme A binding pocket [chemical binding]; other site 512565016987 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565016988 MarR family; Region: MarR_2; pfam12802 512565016989 Pirin-related protein [General function prediction only]; Region: COG1741 512565016990 Pirin; Region: Pirin; pfam02678 512565016991 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 512565016992 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 512565016993 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 512565016994 putative active site [active] 512565016995 catalytic site [active] 512565016996 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 512565016997 putative active site [active] 512565016998 catalytic site [active] 512565016999 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565017000 Coenzyme A binding pocket [chemical binding]; other site 512565017001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565017002 S-adenosylmethionine binding site [chemical binding]; other site 512565017003 Phosphotransferase enzyme family; Region: APH; pfam01636 512565017004 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565017005 allantoicase; Provisional; Region: PRK13257 512565017006 Allantoicase repeat; Region: Allantoicase; pfam03561 512565017007 Allantoicase repeat; Region: Allantoicase; pfam03561 512565017008 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 512565017009 allantoinase; Region: allantoinase; TIGR03178 512565017010 active site 512565017011 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565017012 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 512565017013 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 512565017014 malate synthase A; Region: malate_syn_A; TIGR01344 512565017015 active site 512565017016 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 512565017017 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 512565017018 active site 512565017019 putative substrate binding pocket [chemical binding]; other site 512565017020 urate oxidase; Region: urate_oxi; TIGR03383 512565017021 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 512565017022 active site 512565017023 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 512565017024 active site 512565017025 homotetramer interface [polypeptide binding]; other site 512565017026 putative OHCU decarboxylase; Provisional; Region: PRK13798 512565017027 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 512565017028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 512565017029 ATP binding site [chemical binding]; other site 512565017030 putative Mg++ binding site [ion binding]; other site 512565017031 Helicase associated domain (HA2); Region: HA2; cl04503 512565017032 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 512565017033 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565017034 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565017035 metal binding site [ion binding]; metal-binding site 512565017036 active site 512565017037 I-site; other site 512565017038 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565017039 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 512565017040 active site 512565017041 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565017042 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512565017043 substrate binding pocket [chemical binding]; other site 512565017044 membrane-bound complex binding site; other site 512565017045 hinge residues; other site 512565017046 Haemolytic domain; Region: Haemolytic; pfam01809 512565017047 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 512565017048 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 512565017049 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 512565017050 catalytic site [active] 512565017051 active site 512565017052 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 512565017053 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 512565017054 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 512565017055 active site 512565017056 catalytic site [active] 512565017057 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 512565017058 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 512565017059 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 512565017060 active site 512565017061 catalytic site [active] 512565017062 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 512565017063 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 512565017064 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 512565017065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565017066 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565017067 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 512565017068 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 512565017069 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 512565017070 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 512565017071 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 512565017072 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565017073 PAC2 family; Region: PAC2; pfam09754 512565017074 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565017075 YCII-related domain; Region: YCII; cl00999 512565017076 PAS fold; Region: PAS_4; pfam08448 512565017077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565017078 putative active site [active] 512565017079 heme pocket [chemical binding]; other site 512565017080 GAF domain; Region: GAF_3; pfam13492 512565017081 GAF domain; Region: GAF_2; pfam13185 512565017082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565017083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565017084 dimer interface [polypeptide binding]; other site 512565017085 phosphorylation site [posttranslational modification] 512565017086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565017087 ATP binding site [chemical binding]; other site 512565017088 Mg2+ binding site [ion binding]; other site 512565017089 G-X-G motif; other site 512565017090 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 512565017091 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 512565017092 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 512565017093 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 512565017094 TAP-like protein; Region: Abhydrolase_4; pfam08386 512565017095 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565017096 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 512565017097 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 512565017098 Na binding site [ion binding]; other site 512565017099 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 512565017100 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565017101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565017102 motif II; other site 512565017103 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 512565017104 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 512565017105 Ligand binding site; other site 512565017106 Putative Catalytic site; other site 512565017107 DXD motif; other site 512565017108 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 512565017109 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 512565017110 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565017111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565017112 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 512565017113 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565017114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565017115 ATP binding site [chemical binding]; other site 512565017116 Mg2+ binding site [ion binding]; other site 512565017117 G-X-G motif; other site 512565017118 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565017119 MarR family; Region: MarR; pfam01047 512565017120 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 512565017121 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565017122 Lsr2; Region: Lsr2; pfam11774 512565017123 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 512565017124 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 512565017125 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 512565017126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565017127 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565017128 DNA binding residues [nucleotide binding] 512565017129 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 512565017130 Family description; Region: UvrD_C_2; pfam13538 512565017131 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 512565017132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565017133 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565017134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565017135 DNA binding residues [nucleotide binding] 512565017136 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512565017137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 512565017138 ATP binding site [chemical binding]; other site 512565017139 putative Mg++ binding site [ion binding]; other site 512565017140 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565017141 nucleotide binding region [chemical binding]; other site 512565017142 ATP-binding site [chemical binding]; other site 512565017143 YceI-like domain; Region: YceI; pfam04264 512565017144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565017145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565017146 DNA binding residues [nucleotide binding] 512565017147 dimerization interface [polypeptide binding]; other site 512565017148 AAA ATPase domain; Region: AAA_16; pfam13191 512565017149 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 512565017150 Uncharacterized conserved protein [Function unknown]; Region: COG4850 512565017151 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 512565017152 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 512565017153 NAD-dependent deacetylase; Provisional; Region: PRK00481 512565017154 NAD+ binding site [chemical binding]; other site 512565017155 substrate binding site [chemical binding]; other site 512565017156 Zn binding site [ion binding]; other site 512565017157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565017158 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565017159 DNA binding site [nucleotide binding] 512565017160 domain linker motif; other site 512565017161 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565017162 dimerization interface [polypeptide binding]; other site 512565017163 ligand binding site [chemical binding]; other site 512565017164 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 512565017165 substrate binding site [chemical binding]; other site 512565017166 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 512565017167 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565017168 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565017169 Walker A/P-loop; other site 512565017170 ATP binding site [chemical binding]; other site 512565017171 Q-loop/lid; other site 512565017172 ABC transporter signature motif; other site 512565017173 Walker B; other site 512565017174 D-loop; other site 512565017175 H-loop/switch region; other site 512565017176 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565017177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565017178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565017179 dimer interface [polypeptide binding]; other site 512565017180 conserved gate region; other site 512565017181 putative PBP binding loops; other site 512565017182 ABC-ATPase subunit interface; other site 512565017183 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512565017184 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 512565017185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565017186 dimer interface [polypeptide binding]; other site 512565017187 conserved gate region; other site 512565017188 putative PBP binding loops; other site 512565017189 ABC-ATPase subunit interface; other site 512565017190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565017191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565017192 Walker A/P-loop; other site 512565017193 ATP binding site [chemical binding]; other site 512565017194 Q-loop/lid; other site 512565017195 ABC transporter signature motif; other site 512565017196 Walker B; other site 512565017197 D-loop; other site 512565017198 H-loop/switch region; other site 512565017199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565017200 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 512565017201 beta-galactosidase; Region: BGL; TIGR03356 512565017202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565017203 S-adenosylmethionine binding site [chemical binding]; other site 512565017204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565017205 active site 512565017206 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565017207 catalytic tetrad [active] 512565017208 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565017209 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565017210 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 512565017211 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 512565017212 CAP-like domain; other site 512565017213 active site 512565017214 primary dimer interface [polypeptide binding]; other site 512565017215 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565017216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512565017217 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 512565017218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565017219 ATP binding site [chemical binding]; other site 512565017220 Mg2+ binding site [ion binding]; other site 512565017221 G-X-G motif; other site 512565017222 DNA gyrase B; Region: DNA_gyraseB; pfam00204 512565017223 ATP binding site [chemical binding]; other site 512565017224 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 512565017225 active site 512565017226 metal binding site [ion binding]; metal-binding site 512565017227 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 512565017228 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 512565017229 cyclase homology domain; Region: CHD; cd07302 512565017230 nucleotidyl binding site; other site 512565017231 metal binding site [ion binding]; metal-binding site 512565017232 dimer interface [polypeptide binding]; other site 512565017233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565017234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565017235 DNA binding residues [nucleotide binding] 512565017236 dimerization interface [polypeptide binding]; other site 512565017237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565017238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565017239 dimer interface [polypeptide binding]; other site 512565017240 phosphorylation site [posttranslational modification] 512565017241 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 512565017242 Mg2+ binding site [ion binding]; other site 512565017243 G-X-G motif; other site 512565017244 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565017245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017246 active site 512565017247 phosphorylation site [posttranslational modification] 512565017248 intermolecular recognition site; other site 512565017249 dimerization interface [polypeptide binding]; other site 512565017250 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565017251 DNA binding site [nucleotide binding] 512565017252 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 512565017253 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512565017254 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 512565017255 putative dimer interface [polypeptide binding]; other site 512565017256 N-terminal domain interface [polypeptide binding]; other site 512565017257 putative substrate binding pocket (H-site) [chemical binding]; other site 512565017258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565017259 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 512565017260 NAD(P) binding site [chemical binding]; other site 512565017261 active site 512565017262 SWIM zinc finger; Region: SWIM; pfam04434 512565017263 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565017264 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 512565017265 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 512565017266 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565017267 metal ion-dependent adhesion site (MIDAS); other site 512565017268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565017269 S-adenosylmethionine binding site [chemical binding]; other site 512565017270 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 512565017271 active site 512565017272 catalytic triad [active] 512565017273 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 512565017274 nudix motif; other site 512565017275 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 512565017276 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 512565017277 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 512565017278 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 512565017279 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565017280 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565017281 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565017282 DNA binding residues [nucleotide binding] 512565017283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565017284 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565017285 Walker A motif; other site 512565017286 ATP binding site [chemical binding]; other site 512565017287 Walker B motif; other site 512565017288 arginine finger; other site 512565017289 Domain of unknown function (DUF385); Region: DUF385; pfam04075 512565017290 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565017291 active site 512565017292 catalytic residues [active] 512565017293 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 512565017294 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 512565017295 Moco binding site; other site 512565017296 metal coordination site [ion binding]; other site 512565017297 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 512565017298 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 512565017299 FAD binding pocket [chemical binding]; other site 512565017300 FAD binding motif [chemical binding]; other site 512565017301 phosphate binding motif [ion binding]; other site 512565017302 beta-alpha-beta structure motif; other site 512565017303 NAD binding pocket [chemical binding]; other site 512565017304 Melibiase; Region: Melibiase; pfam02065 512565017305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565017306 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565017307 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565017308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565017309 dimer interface [polypeptide binding]; other site 512565017310 conserved gate region; other site 512565017311 putative PBP binding loops; other site 512565017312 ABC-ATPase subunit interface; other site 512565017313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565017314 dimer interface [polypeptide binding]; other site 512565017315 conserved gate region; other site 512565017316 ABC-ATPase subunit interface; other site 512565017317 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 512565017318 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 512565017319 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 512565017320 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 512565017321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565017322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565017323 DNA binding site [nucleotide binding] 512565017324 domain linker motif; other site 512565017325 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565017326 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 512565017327 active site 512565017328 catalytic triad [active] 512565017329 oxyanion hole [active] 512565017330 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 512565017331 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565017332 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565017333 active site 512565017334 ATP binding site [chemical binding]; other site 512565017335 substrate binding site [chemical binding]; other site 512565017336 activation loop (A-loop); other site 512565017337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565017338 PAS domain; Region: PAS_9; pfam13426 512565017339 putative active site [active] 512565017340 heme pocket [chemical binding]; other site 512565017341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565017342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565017343 dimer interface [polypeptide binding]; other site 512565017344 phosphorylation site [posttranslational modification] 512565017345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565017346 ATP binding site [chemical binding]; other site 512565017347 Mg2+ binding site [ion binding]; other site 512565017348 G-X-G motif; other site 512565017349 Response regulator receiver domain; Region: Response_reg; pfam00072 512565017350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017351 active site 512565017352 phosphorylation site [posttranslational modification] 512565017353 intermolecular recognition site; other site 512565017354 dimerization interface [polypeptide binding]; other site 512565017355 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 512565017356 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 512565017357 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565017358 active site 512565017359 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565017360 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565017361 Walker A/P-loop; other site 512565017362 ATP binding site [chemical binding]; other site 512565017363 Q-loop/lid; other site 512565017364 ABC transporter signature motif; other site 512565017365 Walker B; other site 512565017366 D-loop; other site 512565017367 H-loop/switch region; other site 512565017368 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565017369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565017370 Walker A/P-loop; other site 512565017371 ATP binding site [chemical binding]; other site 512565017372 Q-loop/lid; other site 512565017373 ABC transporter signature motif; other site 512565017374 Walker B; other site 512565017375 D-loop; other site 512565017376 H-loop/switch region; other site 512565017377 FtsX-like permease family; Region: FtsX; pfam02687 512565017378 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 512565017379 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 512565017380 oligomer interface [polypeptide binding]; other site 512565017381 metal binding site [ion binding]; metal-binding site 512565017382 metal binding site [ion binding]; metal-binding site 512565017383 putative Cl binding site [ion binding]; other site 512565017384 aspartate ring; other site 512565017385 basic sphincter; other site 512565017386 hydrophobic gate; other site 512565017387 periplasmic entrance; other site 512565017388 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 512565017389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565017390 putative substrate translocation pore; other site 512565017391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565017392 tetracycline repressor protein TetR; Provisional; Region: PRK13756 512565017393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565017394 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565017395 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 512565017396 Carbohydrate binding domain; Region: CBM_25; smart01066 512565017397 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 512565017398 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512565017399 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 512565017400 active site 512565017401 catalytic site [active] 512565017402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565017403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565017404 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 512565017405 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512565017406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565017407 active site 512565017408 metal binding site [ion binding]; metal-binding site 512565017409 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 512565017410 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565017411 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 512565017412 TIR domain; Region: TIR_2; cl17458 512565017413 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565017414 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565017415 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565017416 structural tetrad; other site 512565017417 FOG: WD40 repeat [General function prediction only]; Region: COG2319 512565017418 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565017419 structural tetrad; other site 512565017420 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 512565017421 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565017422 DNA binding site [nucleotide binding] 512565017423 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565017424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565017425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565017426 TPR motif; other site 512565017427 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565017428 binding surface 512565017429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565017430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017431 active site 512565017432 phosphorylation site [posttranslational modification] 512565017433 intermolecular recognition site; other site 512565017434 dimerization interface [polypeptide binding]; other site 512565017435 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565017436 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 512565017437 Walker A motif; other site 512565017438 ATP binding site [chemical binding]; other site 512565017439 Walker B motif; other site 512565017440 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565017441 Walker A motif; other site 512565017442 ATP binding site [chemical binding]; other site 512565017443 Walker B motif; other site 512565017444 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565017445 G1 box; other site 512565017446 GTP/Mg2+ binding site [chemical binding]; other site 512565017447 G2 box; other site 512565017448 Switch I region; other site 512565017449 G3 box; other site 512565017450 Switch II region; other site 512565017451 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565017452 G1 box; other site 512565017453 GTP/Mg2+ binding site [chemical binding]; other site 512565017454 G2 box; other site 512565017455 Switch I region; other site 512565017456 G3 box; other site 512565017457 Switch II region; other site 512565017458 G4 box; other site 512565017459 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565017460 G1 box; other site 512565017461 GTP/Mg2+ binding site [chemical binding]; other site 512565017462 G2 box; other site 512565017463 Switch I region; other site 512565017464 G3 box; other site 512565017465 Switch II region; other site 512565017466 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565017467 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565017468 putative NAD(P) binding site [chemical binding]; other site 512565017469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565017470 Histidine kinase; Region: HisKA_3; pfam07730 512565017471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565017472 ATP binding site [chemical binding]; other site 512565017473 Mg2+ binding site [ion binding]; other site 512565017474 G-X-G motif; other site 512565017475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565017476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017477 active site 512565017478 phosphorylation site [posttranslational modification] 512565017479 intermolecular recognition site; other site 512565017480 dimerization interface [polypeptide binding]; other site 512565017481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565017482 DNA binding residues [nucleotide binding] 512565017483 dimerization interface [polypeptide binding]; other site 512565017484 Lipase (class 2); Region: Lipase_2; pfam01674 512565017485 PGAP1-like protein; Region: PGAP1; pfam07819 512565017486 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 512565017487 Domain of unknown function DUF11; Region: DUF11; pfam01345 512565017488 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565017489 DNA binding site [nucleotide binding] 512565017490 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565017491 AAA ATPase domain; Region: AAA_16; pfam13191 512565017492 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 512565017493 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 512565017494 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565017495 Rrf2 family protein; Region: rrf2_super; TIGR00738 512565017496 Transcriptional regulator; Region: Rrf2; pfam02082 512565017497 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 512565017498 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 512565017499 Interdomain contacts; other site 512565017500 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565017501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565017502 metal binding site [ion binding]; metal-binding site 512565017503 active site 512565017504 I-site; other site 512565017505 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565017506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 512565017507 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 512565017508 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 512565017509 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 512565017510 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 512565017511 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 512565017512 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 512565017513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 512565017514 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 512565017515 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565017516 DinB superfamily; Region: DinB_2; pfam12867 512565017517 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565017518 putative catalytic site [active] 512565017519 putative metal binding site [ion binding]; other site 512565017520 putative phosphate binding site [ion binding]; other site 512565017521 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 512565017522 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 512565017523 active site 512565017524 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 512565017525 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 512565017526 active site 512565017527 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 512565017528 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 512565017529 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 512565017530 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512565017531 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 512565017532 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565017533 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565017534 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 512565017535 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565017536 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565017537 DNA binding site [nucleotide binding] 512565017538 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 512565017539 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565017540 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 512565017541 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 512565017542 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 512565017543 calcium binding site 2 [ion binding]; other site 512565017544 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 512565017545 active site 512565017546 catalytic triad [active] 512565017547 calcium binding site 1 [ion binding]; other site 512565017548 Putative Ig domain; Region: He_PIG; pfam05345 512565017549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565017550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017551 active site 512565017552 phosphorylation site [posttranslational modification] 512565017553 intermolecular recognition site; other site 512565017554 dimerization interface [polypeptide binding]; other site 512565017555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565017556 DNA binding residues [nucleotide binding] 512565017557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565017558 Histidine kinase; Region: HisKA_3; pfam07730 512565017559 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 512565017560 Pectate lyase; Region: Pectate_lyase; pfam03211 512565017561 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 512565017562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565017563 motif II; other site 512565017564 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 512565017565 conserved cys residue [active] 512565017566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565017567 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 512565017568 Isochorismatase family; Region: Isochorismatase; pfam00857 512565017569 catalytic triad [active] 512565017570 conserved cis-peptide bond; other site 512565017571 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 512565017572 DNA binding residues [nucleotide binding] 512565017573 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565017574 putative dimer interface [polypeptide binding]; other site 512565017575 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 512565017576 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565017577 DNA binding residues [nucleotide binding] 512565017578 putative dimer interface [polypeptide binding]; other site 512565017579 PRC-barrel domain; Region: PRC; pfam05239 512565017580 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 512565017581 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565017582 substrate binding site [chemical binding]; other site 512565017583 ATP binding site [chemical binding]; other site 512565017584 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 512565017585 active site 512565017586 intersubunit interface [polypeptide binding]; other site 512565017587 catalytic residue [active] 512565017588 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565017589 Bacterial transcriptional activator domain; Region: BTAD; smart01043 512565017590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512565017591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565017592 S-adenosylmethionine binding site [chemical binding]; other site 512565017593 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565017594 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 512565017595 putative NAD(P) binding site [chemical binding]; other site 512565017596 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 512565017597 amidase catalytic site [active] 512565017598 Zn binding residues [ion binding]; other site 512565017599 substrate binding site [chemical binding]; other site 512565017600 TspO/MBR family; Region: TspO_MBR; pfam03073 512565017601 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512565017602 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 512565017603 Ca binding site [ion binding]; other site 512565017604 active site 512565017605 catalytic site [active] 512565017606 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 512565017607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565017608 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 512565017609 putative ADP-binding pocket [chemical binding]; other site 512565017610 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 512565017611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565017612 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 512565017613 active site 512565017614 hypothetical protein; Provisional; Region: PRK08317 512565017615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565017616 S-adenosylmethionine binding site [chemical binding]; other site 512565017617 putative oxidoreductase; Provisional; Region: PRK11579 512565017618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565017619 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512565017620 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565017621 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565017622 active site 512565017623 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565017624 kynureninase; Region: kynureninase; TIGR01814 512565017625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565017626 catalytic residue [active] 512565017627 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 512565017628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 512565017629 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565017630 putative CheW interface [polypeptide binding]; other site 512565017631 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565017632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565017633 DNA binding site [nucleotide binding] 512565017634 domain linker motif; other site 512565017635 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565017636 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565017637 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512565017638 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 512565017639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565017640 dimer interface [polypeptide binding]; other site 512565017641 conserved gate region; other site 512565017642 putative PBP binding loops; other site 512565017643 ABC-ATPase subunit interface; other site 512565017644 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565017645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565017646 dimer interface [polypeptide binding]; other site 512565017647 conserved gate region; other site 512565017648 ABC-ATPase subunit interface; other site 512565017649 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512565017650 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 512565017651 active site 512565017652 catalytic site [active] 512565017653 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565017654 sugar binding site [chemical binding]; other site 512565017655 CARDB; Region: CARDB; pfam07705 512565017656 CARDB; Region: CARDB; pfam07705 512565017657 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 512565017658 putative metal binding site [ion binding]; other site 512565017659 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 512565017660 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 512565017661 Sulfate transporter family; Region: Sulfate_transp; pfam00916 512565017662 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 512565017663 active site clefts [active] 512565017664 zinc binding site [ion binding]; other site 512565017665 dimer interface [polypeptide binding]; other site 512565017666 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565017667 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 512565017668 NAD binding site [chemical binding]; other site 512565017669 homotetramer interface [polypeptide binding]; other site 512565017670 homodimer interface [polypeptide binding]; other site 512565017671 active site 512565017672 substrate binding site [chemical binding]; other site 512565017673 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 512565017674 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565017675 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565017676 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 512565017677 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 512565017678 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 512565017679 active site 512565017680 dimer interface [polypeptide binding]; other site 512565017681 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 512565017682 Ligand Binding Site [chemical binding]; other site 512565017683 Molecular Tunnel; other site 512565017684 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565017685 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565017686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565017687 putative substrate translocation pore; other site 512565017688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565017689 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 512565017690 DinB superfamily; Region: DinB_2; pfam12867 512565017691 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565017692 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565017693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565017694 ligand binding site [chemical binding]; other site 512565017695 flexible hinge region; other site 512565017696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565017697 ATP binding site [chemical binding]; other site 512565017698 Mg2+ binding site [ion binding]; other site 512565017699 G-X-G motif; other site 512565017700 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565017701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017702 active site 512565017703 phosphorylation site [posttranslational modification] 512565017704 intermolecular recognition site; other site 512565017705 dimerization interface [polypeptide binding]; other site 512565017706 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 512565017707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565017708 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565017709 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 512565017710 ATP-NAD kinase; Region: NAD_kinase; pfam01513 512565017711 Predicted acetyltransferase [General function prediction only]; Region: COG2388 512565017712 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565017713 Phosphotransferase enzyme family; Region: APH; pfam01636 512565017714 active site 512565017715 ATP binding site [chemical binding]; other site 512565017716 Domain of unknown function (DUF222); Region: DUF222; pfam02720 512565017717 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 512565017718 active site 512565017719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512565017720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512565017721 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 512565017722 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565017723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565017724 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 512565017725 dimer interface [polypeptide binding]; other site 512565017726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565017727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565017728 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565017729 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565017730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565017731 Walker A/P-loop; other site 512565017732 ATP binding site [chemical binding]; other site 512565017733 Q-loop/lid; other site 512565017734 ABC transporter signature motif; other site 512565017735 Walker B; other site 512565017736 D-loop; other site 512565017737 H-loop/switch region; other site 512565017738 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512565017739 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512565017740 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 512565017741 Walker A/P-loop; other site 512565017742 ATP binding site [chemical binding]; other site 512565017743 Q-loop/lid; other site 512565017744 ABC transporter signature motif; other site 512565017745 Walker B; other site 512565017746 D-loop; other site 512565017747 H-loop/switch region; other site 512565017748 Calx-beta domain; Region: Calx-beta; cl02522 512565017749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565017750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017751 active site 512565017752 phosphorylation site [posttranslational modification] 512565017753 intermolecular recognition site; other site 512565017754 dimerization interface [polypeptide binding]; other site 512565017755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565017756 DNA binding residues [nucleotide binding] 512565017757 dimerization interface [polypeptide binding]; other site 512565017758 Histidine kinase; Region: HisKA_3; pfam07730 512565017759 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565017760 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 512565017761 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565017762 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565017763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565017764 Walker A/P-loop; other site 512565017765 ATP binding site [chemical binding]; other site 512565017766 Q-loop/lid; other site 512565017767 ABC transporter signature motif; other site 512565017768 Walker B; other site 512565017769 D-loop; other site 512565017770 H-loop/switch region; other site 512565017771 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565017772 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512565017773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565017774 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565017775 Walker A/P-loop; other site 512565017776 ATP binding site [chemical binding]; other site 512565017777 Q-loop/lid; other site 512565017778 ABC transporter signature motif; other site 512565017779 Walker B; other site 512565017780 D-loop; other site 512565017781 H-loop/switch region; other site 512565017782 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 512565017783 RNA/DNA hybrid binding site [nucleotide binding]; other site 512565017784 active site 512565017785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565017786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565017787 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 512565017788 nucleotide binding site [chemical binding]; other site 512565017789 Histidine kinase; Region: HisKA_3; pfam07730 512565017790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565017791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565017792 active site 512565017793 phosphorylation site [posttranslational modification] 512565017794 intermolecular recognition site; other site 512565017795 dimerization interface [polypeptide binding]; other site 512565017796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565017797 DNA binding residues [nucleotide binding] 512565017798 dimerization interface [polypeptide binding]; other site 512565017799 PAS domain S-box; Region: sensory_box; TIGR00229 512565017800 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565017801 putative active site [active] 512565017802 heme pocket [chemical binding]; other site 512565017803 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565017804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565017805 metal binding site [ion binding]; metal-binding site 512565017806 active site 512565017807 I-site; other site 512565017808 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565017809 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565017810 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 512565017811 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 512565017812 metal binding site [ion binding]; metal-binding site 512565017813 ligand binding site [chemical binding]; other site 512565017814 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 512565017815 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 512565017816 putative dimer interface [polypeptide binding]; other site 512565017817 DNA polymerase IV; Validated; Region: PRK03858 512565017818 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 512565017819 active site 512565017820 DNA binding site [nucleotide binding] 512565017821 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 512565017822 active site 512565017823 SAM binding site [chemical binding]; other site 512565017824 homodimer interface [polypeptide binding]; other site 512565017825 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 512565017826 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 512565017827 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 512565017828 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 512565017829 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 512565017830 Precorrin-8X methylmutase; Region: CbiC; pfam02570 512565017831 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 512565017832 SAM binding site [chemical binding]; other site 512565017833 active site 512565017834 homodimer interface [polypeptide binding]; other site 512565017835 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 512565017836 active site 512565017837 SAM binding site [chemical binding]; other site 512565017838 homodimer interface [polypeptide binding]; other site 512565017839 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 512565017840 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565017841 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565017842 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565017843 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 512565017844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565017845 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565017846 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 512565017847 Ligand binding site; other site 512565017848 Putative Catalytic site; other site 512565017849 DXD motif; other site 512565017850 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 512565017851 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565017852 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 512565017853 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512565017854 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 512565017855 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 512565017856 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 512565017857 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 512565017858 putative active site [active] 512565017859 catalytic site [active] 512565017860 putative metal binding site [ion binding]; other site 512565017861 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 512565017862 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 512565017863 FAD binding pocket [chemical binding]; other site 512565017864 FAD binding motif [chemical binding]; other site 512565017865 phosphate binding motif [ion binding]; other site 512565017866 NAD binding pocket [chemical binding]; other site 512565017867 cyanate transporter; Region: CynX; TIGR00896 512565017868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565017869 putative substrate translocation pore; other site 512565017870 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 512565017871 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 512565017872 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 512565017873 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 512565017874 homodimer interface [polypeptide binding]; other site 512565017875 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 512565017876 active site pocket [active] 512565017877 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565017878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565017879 DNA binding residues [nucleotide binding] 512565017880 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565017881 Ricin-type beta-trefoil; Region: RICIN; smart00458 512565017882 putative sugar binding sites [chemical binding]; other site 512565017883 Q-X-W motif; other site 512565017884 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565017885 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565017886 putative sugar binding sites [chemical binding]; other site 512565017887 Q-X-W motif; other site 512565017888 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 512565017889 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 512565017890 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 512565017891 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565017892 anti sigma factor interaction site; other site 512565017893 regulatory phosphorylation site [posttranslational modification]; other site 512565017894 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 512565017895 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 512565017896 substrate binding pocket [chemical binding]; other site 512565017897 chain length determination region; other site 512565017898 substrate-Mg2+ binding site; other site 512565017899 catalytic residues [active] 512565017900 aspartate-rich region 1; other site 512565017901 active site lid residues [active] 512565017902 aspartate-rich region 2; other site 512565017903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565017904 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565017905 active site 512565017906 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565017907 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 512565017908 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 512565017909 dimer interface [polypeptide binding]; other site 512565017910 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512565017911 active site 512565017912 metal binding site [ion binding]; metal-binding site 512565017913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565017914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565017915 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 512565017916 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 512565017917 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 512565017918 shikimate binding site; other site 512565017919 NAD(P) binding site [chemical binding]; other site 512565017920 YCII-related domain; Region: YCII; cl00999 512565017921 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 512565017922 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565017923 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565017924 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 512565017925 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565017926 metal ion-dependent adhesion site (MIDAS); other site 512565017927 hypothetical protein; Provisional; Region: PRK13685 512565017928 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565017929 metal ion-dependent adhesion site (MIDAS); other site 512565017930 von Willebrand factor type A domain; Region: VWA_2; pfam13519 512565017931 metal ion-dependent adhesion site (MIDAS); other site 512565017932 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 512565017933 Protein of unknown function DUF58; Region: DUF58; pfam01882 512565017934 MoxR-like ATPases [General function prediction only]; Region: COG0714 512565017935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565017936 Walker A motif; other site 512565017937 ATP binding site [chemical binding]; other site 512565017938 Walker B motif; other site 512565017939 arginine finger; other site 512565017940 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565017941 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 512565017942 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 512565017943 Cellulose binding domain; Region: CBM_2; pfam00553 512565017944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565017945 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565017946 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 512565017947 Walker A motif; other site 512565017948 ATP binding site [chemical binding]; other site 512565017949 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 512565017950 metal ion-dependent adhesion site (MIDAS); other site 512565017951 MMPL family; Region: MMPL; pfam03176 512565017952 MMPL family; Region: MMPL; pfam03176 512565017953 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 512565017954 3-oxoacyl-[acyl-carrier-protein] synthase; Region: PLN02836 512565017955 active site 512565017956 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 512565017957 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 512565017958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 512565017959 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 512565017960 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 512565017961 substrate-cofactor binding pocket; other site 512565017962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565017963 catalytic residue [active] 512565017964 Part of AAA domain; Region: AAA_19; pfam13245 512565017965 Family description; Region: UvrD_C_2; pfam13538 512565017966 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 512565017967 PLD-like domain; Region: PLDc_2; pfam13091 512565017968 putative active site [active] 512565017969 catalytic site [active] 512565017970 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 512565017971 putative homodimer interface [polypeptide binding]; other site 512565017972 putative active site [active] 512565017973 catalytic site [active] 512565017974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565017975 AAA domain; Region: AAA_23; pfam13476 512565017976 Walker A/P-loop; other site 512565017977 ATP binding site [chemical binding]; other site 512565017978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565017979 ABC transporter signature motif; other site 512565017980 Walker B; other site 512565017981 D-loop; other site 512565017982 H-loop/switch region; other site 512565017983 potential frameshift: common BLAST hit: gi|134101642|ref|YP_001107303.1| superfamily protein I DNA/RNA helicase 512565017984 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512565017985 AAA domain; Region: AAA_12; pfam13087 512565017986 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512565017987 putative active site [active] 512565017988 Part of AAA domain; Region: AAA_19; pfam13245 512565017989 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 512565017990 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565017991 HsdM N-terminal domain; Region: HsdM_N; pfam12161 512565017992 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 512565017993 Methyltransferase domain; Region: Methyltransf_26; pfam13659 512565017994 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512565017995 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 512565017996 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 512565017997 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 512565017998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565017999 ATP binding site [chemical binding]; other site 512565018000 putative Mg++ binding site [ion binding]; other site 512565018001 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 512565018002 NHL repeat; Region: NHL; pfam01436 512565018003 NHL repeat; Region: NHL; pfam01436 512565018004 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 512565018005 active site 512565018006 Helix-turn-helix domain; Region: HTH_17; pfam12728 512565018007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565018008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565018009 active site 512565018010 DNA binding site [nucleotide binding] 512565018011 Int/Topo IB signature motif; other site 512565018012 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512565018013 active site 512565018014 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 512565018015 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565018016 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 512565018017 protein binding site [polypeptide binding]; other site 512565018018 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565018019 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 512565018020 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512565018021 DXD motif; other site 512565018022 Baseplate structural protein, domain 2; Region: Phage-tail_2; pfam09096 512565018023 ApbE family; Region: ApbE; pfam02424 512565018024 FMN-binding domain; Region: FMN_bind; pfam04205 512565018025 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 512565018026 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 512565018027 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 512565018028 FAD binding pocket [chemical binding]; other site 512565018029 FAD binding motif [chemical binding]; other site 512565018030 phosphate binding motif [ion binding]; other site 512565018031 beta-alpha-beta structure motif; other site 512565018032 NAD binding pocket [chemical binding]; other site 512565018033 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 512565018034 putative homodimer interface [polypeptide binding]; other site 512565018035 active site 512565018036 SAM binding site [chemical binding]; other site 512565018037 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 512565018038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565018039 S-adenosylmethionine binding site [chemical binding]; other site 512565018040 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 512565018041 active site 512565018042 SAM binding site [chemical binding]; other site 512565018043 homodimer interface [polypeptide binding]; other site 512565018044 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 512565018045 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 512565018046 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512565018047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565018048 NAD(P) binding site [chemical binding]; other site 512565018049 active site 512565018050 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 512565018051 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 512565018052 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 512565018053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 512565018054 Penicillin amidase; Region: Penicil_amidase; pfam01804 512565018055 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 512565018056 active site 512565018057 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 512565018058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 512565018059 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 512565018060 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 512565018061 IucA / IucC family; Region: IucA_IucC; pfam04183 512565018062 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 512565018063 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 512565018064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565018065 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 512565018066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565018067 catalytic residue [active] 512565018068 CBD_II domain; Region: CBD_II; smart00637 512565018069 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 512565018070 substrate binding pocket [chemical binding]; other site 512565018071 catalytic residues [active] 512565018072 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 512565018073 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 512565018074 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565018075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565018076 dimer interface [polypeptide binding]; other site 512565018077 conserved gate region; other site 512565018078 putative PBP binding loops; other site 512565018079 ABC-ATPase subunit interface; other site 512565018080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565018081 dimer interface [polypeptide binding]; other site 512565018082 conserved gate region; other site 512565018083 putative PBP binding loops; other site 512565018084 ABC-ATPase subunit interface; other site 512565018085 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512565018086 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565018087 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565018088 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565018089 DNA binding site [nucleotide binding] 512565018090 domain linker motif; other site 512565018091 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565018092 ligand binding site [chemical binding]; other site 512565018093 dimerization interface [polypeptide binding]; other site 512565018094 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 512565018095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565018096 putative substrate translocation pore; other site 512565018097 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 512565018098 nucleotide binding site [chemical binding]; other site 512565018099 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 512565018100 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 512565018101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565018102 active site 512565018103 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 512565018104 PAS domain S-box; Region: sensory_box; TIGR00229 512565018105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565018106 putative active site [active] 512565018107 heme pocket [chemical binding]; other site 512565018108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565018109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565018110 metal binding site [ion binding]; metal-binding site 512565018111 active site 512565018112 I-site; other site 512565018113 Predicted membrane protein [Function unknown]; Region: COG4425 512565018114 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 512565018115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 512565018116 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 512565018117 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565018118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018119 active site 512565018120 phosphorylation site [posttranslational modification] 512565018121 intermolecular recognition site; other site 512565018122 dimerization interface [polypeptide binding]; other site 512565018123 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565018124 DNA binding residues [nucleotide binding] 512565018125 Putative sensor; Region: Sensor; pfam13796 512565018126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565018127 Histidine kinase; Region: HisKA_3; pfam07730 512565018128 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 512565018129 putative di-iron ligands [ion binding]; other site 512565018130 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 512565018131 pyruvate dehydrogenase; Provisional; Region: PRK06546 512565018132 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 512565018133 PYR/PP interface [polypeptide binding]; other site 512565018134 dimer interface [polypeptide binding]; other site 512565018135 tetramer interface [polypeptide binding]; other site 512565018136 TPP binding site [chemical binding]; other site 512565018137 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512565018138 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 512565018139 TPP-binding site [chemical binding]; other site 512565018140 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 512565018141 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 512565018142 active site 512565018143 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 512565018144 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565018145 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 512565018146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565018147 Zn2+ binding site [ion binding]; other site 512565018148 Mg2+ binding site [ion binding]; other site 512565018149 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 512565018150 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512565018151 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 512565018152 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512565018153 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 512565018154 putative lipid kinase; Reviewed; Region: PRK13057 512565018155 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 512565018156 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565018157 GAF domain; Region: GAF; pfam01590 512565018158 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 512565018159 minor groove reading motif; other site 512565018160 helix-hairpin-helix signature motif; other site 512565018161 active site 512565018162 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 512565018163 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 512565018164 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 512565018165 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 512565018166 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565018167 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565018168 DNA binding residues [nucleotide binding] 512565018169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 512565018170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565018171 AAA domain; Region: AAA_23; pfam13476 512565018172 Walker A/P-loop; other site 512565018173 ATP binding site [chemical binding]; other site 512565018174 Q-loop/lid; other site 512565018175 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 512565018176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565018177 ABC transporter signature motif; other site 512565018178 Walker B; other site 512565018179 D-loop; other site 512565018180 H-loop/switch region; other site 512565018181 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 512565018182 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 512565018183 active site 512565018184 metal binding site [ion binding]; metal-binding site 512565018185 DNA binding site [nucleotide binding] 512565018186 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 512565018187 HerA helicase [Replication, recombination, and repair]; Region: COG0433 512565018188 hypothetical protein; Provisional; Region: PRK14059 512565018189 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 512565018190 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 512565018191 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 512565018192 biotin synthase; Validated; Region: PRK06256 512565018193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565018194 FeS/SAM binding site; other site 512565018195 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 512565018196 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 512565018197 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 512565018198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565018199 catalytic residue [active] 512565018200 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 512565018201 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565018202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565018203 nucleotide binding site [chemical binding]; other site 512565018204 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 512565018205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565018206 motif II; other site 512565018207 Predicted methyltransferase [General function prediction only]; Region: COG3897 512565018208 PAS domain S-box; Region: sensory_box; TIGR00229 512565018209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565018210 putative active site [active] 512565018211 heme pocket [chemical binding]; other site 512565018212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565018213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565018214 metal binding site [ion binding]; metal-binding site 512565018215 active site 512565018216 I-site; other site 512565018217 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565018218 Lsr2; Region: Lsr2; pfam11774 512565018219 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565018220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565018221 NAD(P) binding site [chemical binding]; other site 512565018222 active site 512565018223 Actin-Fragmin Kinase (AFK); catalytic domain. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside...; Region: AFK; cl07713 512565018224 ATP binding site [chemical binding]; other site 512565018225 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 512565018226 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 512565018227 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565018228 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565018229 DNA binding residues [nucleotide binding] 512565018230 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 512565018231 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 512565018232 active site 512565018233 DNA binding site [nucleotide binding] 512565018234 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 512565018235 DNA binding site [nucleotide binding] 512565018236 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 512565018237 TAP-like protein; Region: Abhydrolase_4; pfam08386 512565018238 Ion channel; Region: Ion_trans_2; pfam07885 512565018239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565018240 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 512565018241 nucleotide binding site [chemical binding]; other site 512565018242 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 512565018243 SelR domain; Region: SelR; pfam01641 512565018244 Uncharacterized membrane protein (DUF2298); Region: DUF2298; pfam10060 512565018245 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 512565018246 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 512565018247 Ligand binding site; other site 512565018248 Putative Catalytic site; other site 512565018249 DXD motif; other site 512565018250 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 512565018251 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512565018252 folate binding site [chemical binding]; other site 512565018253 NADP+ binding site [chemical binding]; other site 512565018254 thymidylate synthase; Reviewed; Region: thyA; PRK01827 512565018255 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 512565018256 dimerization interface [polypeptide binding]; other site 512565018257 active site 512565018258 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 512565018259 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512565018260 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 512565018261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565018262 Coenzyme A binding pocket [chemical binding]; other site 512565018263 Chlorite dismutase; Region: Chlor_dismutase; pfam06778 512565018264 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 512565018265 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 512565018266 substrate binding site [chemical binding]; other site 512565018267 active site 512565018268 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 512565018269 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 512565018270 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565018271 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 512565018272 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 512565018273 catalytic site [active] 512565018274 putative active site [active] 512565018275 putative substrate binding site [chemical binding]; other site 512565018276 Helicase and RNase D C-terminal; Region: HRDC; smart00341 512565018277 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565018278 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 512565018279 dimer interface [polypeptide binding]; other site 512565018280 active site 512565018281 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 512565018282 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565018283 substrate binding site [chemical binding]; other site 512565018284 oxyanion hole (OAH) forming residues; other site 512565018285 trimer interface [polypeptide binding]; other site 512565018286 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 512565018287 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 512565018288 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 512565018289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565018290 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565018291 dimerization interface [polypeptide binding]; other site 512565018292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565018293 dimer interface [polypeptide binding]; other site 512565018294 phosphorylation site [posttranslational modification] 512565018295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565018296 ATP binding site [chemical binding]; other site 512565018297 Mg2+ binding site [ion binding]; other site 512565018298 G-X-G motif; other site 512565018299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565018300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018301 active site 512565018302 phosphorylation site [posttranslational modification] 512565018303 intermolecular recognition site; other site 512565018304 dimerization interface [polypeptide binding]; other site 512565018305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565018306 DNA binding site [nucleotide binding] 512565018307 PQQ-like domain; Region: PQQ_2; pfam13360 512565018308 PQQ-like domain; Region: PQQ_2; pfam13360 512565018309 PQQ-like domain; Region: PQQ_2; pfam13360 512565018310 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 512565018311 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 512565018312 TPP-binding site; other site 512565018313 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512565018314 PYR/PP interface [polypeptide binding]; other site 512565018315 dimer interface [polypeptide binding]; other site 512565018316 TPP binding site [chemical binding]; other site 512565018317 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512565018318 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 512565018319 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 512565018320 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 512565018321 homodimer interface [polypeptide binding]; other site 512565018322 NADP binding site [chemical binding]; other site 512565018323 substrate binding site [chemical binding]; other site 512565018324 TRAM domain; Region: TRAM; pfam01938 512565018325 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 512565018326 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 512565018327 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 512565018328 TrkA-N domain; Region: TrkA_N; pfam02254 512565018329 TrkA-C domain; Region: TrkA_C; pfam02080 512565018330 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 512565018331 TrkA-N domain; Region: TrkA_N; pfam02254 512565018332 TrkA-C domain; Region: TrkA_C; pfam02080 512565018333 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 512565018334 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 512565018335 ssDNA binding site; other site 512565018336 generic binding surface II; other site 512565018337 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 512565018338 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 512565018339 trimer interface [polypeptide binding]; other site 512565018340 active site 512565018341 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 512565018342 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 512565018343 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 512565018344 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512565018345 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 512565018346 active site 512565018347 dimerization interface [polypeptide binding]; other site 512565018348 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 512565018349 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 512565018350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565018351 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565018352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565018353 DNA binding residues [nucleotide binding] 512565018354 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 512565018355 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565018356 ATP binding site [chemical binding]; other site 512565018357 putative Mg++ binding site [ion binding]; other site 512565018358 Predicted membrane protein [Function unknown]; Region: COG2860 512565018359 UPF0126 domain; Region: UPF0126; pfam03458 512565018360 UPF0126 domain; Region: UPF0126; pfam03458 512565018361 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 512565018362 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 512565018363 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565018364 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512565018365 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 512565018366 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 512565018367 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565018368 GAF domain; Region: GAF; pfam01590 512565018369 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565018370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565018371 dimer interface [polypeptide binding]; other site 512565018372 putative CheW interface [polypeptide binding]; other site 512565018373 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565018374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018375 active site 512565018376 phosphorylation site [posttranslational modification] 512565018377 intermolecular recognition site; other site 512565018378 dimerization interface [polypeptide binding]; other site 512565018379 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 512565018380 putative binding surface; other site 512565018381 active site 512565018382 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 512565018383 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 512565018384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565018385 ATP binding site [chemical binding]; other site 512565018386 Mg2+ binding site [ion binding]; other site 512565018387 G-X-G motif; other site 512565018388 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 512565018389 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565018390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018391 active site 512565018392 phosphorylation site [posttranslational modification] 512565018393 intermolecular recognition site; other site 512565018394 dimerization interface [polypeptide binding]; other site 512565018395 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 512565018396 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 512565018397 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 512565018398 HEAT repeats; Region: HEAT_2; pfam13646 512565018399 HEAT repeats; Region: HEAT_2; pfam13646 512565018400 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 512565018401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018402 active site 512565018403 phosphorylation site [posttranslational modification] 512565018404 intermolecular recognition site; other site 512565018405 dimerization interface [polypeptide binding]; other site 512565018406 CheB methylesterase; Region: CheB_methylest; pfam01339 512565018407 CheW-like domain; Region: CheW; pfam01584 512565018408 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 512565018409 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 512565018410 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565018411 dimer interface [polypeptide binding]; other site 512565018412 putative CheW interface [polypeptide binding]; other site 512565018413 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 512565018414 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565018415 dimer interface [polypeptide binding]; other site 512565018416 putative CheW interface [polypeptide binding]; other site 512565018417 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 512565018418 putative active site [active] 512565018419 dimerization interface [polypeptide binding]; other site 512565018420 putative tRNAtyr binding site [nucleotide binding]; other site 512565018421 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565018422 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565018423 SpoOM protein; Region: Spo0M; pfam07070 512565018424 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 512565018425 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 512565018426 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565018427 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512565018428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565018429 DNA binding residues [nucleotide binding] 512565018430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565018431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565018432 Coenzyme A binding pocket [chemical binding]; other site 512565018433 CoA binding domain; Region: CoA_binding_2; pfam13380 512565018434 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 512565018435 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 512565018436 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 512565018437 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 512565018438 active site 512565018439 Zn binding site [ion binding]; other site 512565018440 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 512565018441 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 512565018442 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 512565018443 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 512565018444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565018445 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 512565018446 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 512565018447 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 512565018448 active site 512565018449 dimer interface [polypeptide binding]; other site 512565018450 effector binding site; other site 512565018451 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 512565018452 TSCPD domain; Region: TSCPD; pfam12637 512565018453 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 512565018454 ATP cone domain; Region: ATP-cone; pfam03477 512565018455 LexA repressor; Validated; Region: PRK00215 512565018456 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 512565018457 putative switch regulator; other site 512565018458 non-specific DNA interactions [nucleotide binding]; other site 512565018459 DNA binding site [nucleotide binding] 512565018460 sequence specific DNA binding site [nucleotide binding]; other site 512565018461 putative cAMP binding site [chemical binding]; other site 512565018462 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 512565018463 Catalytic site [active] 512565018464 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 512565018465 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 512565018466 HflX GTPase family; Region: HflX; cd01878 512565018467 G1 box; other site 512565018468 GTP/Mg2+ binding site [chemical binding]; other site 512565018469 Switch I region; other site 512565018470 G2 box; other site 512565018471 G3 box; other site 512565018472 Switch II region; other site 512565018473 G4 box; other site 512565018474 G5 box; other site 512565018475 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 512565018476 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 512565018477 Malic enzyme, N-terminal domain; Region: malic; pfam00390 512565018478 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 512565018479 putative NAD(P) binding site [chemical binding]; other site 512565018480 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 512565018481 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 512565018482 active site 512565018483 catalytic site [active] 512565018484 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 512565018485 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 512565018486 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 512565018487 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 512565018488 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 512565018489 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 512565018490 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 512565018491 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 512565018492 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 512565018493 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 512565018494 tetramer interface [polypeptide binding]; other site 512565018495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565018496 catalytic residue [active] 512565018497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565018498 dimerization interface [polypeptide binding]; other site 512565018499 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512565018500 putative DNA binding site [nucleotide binding]; other site 512565018501 putative Zn2+ binding site [ion binding]; other site 512565018502 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 512565018503 putative dimerization interface [polypeptide binding]; other site 512565018504 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 512565018505 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 512565018506 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565018507 FeS/SAM binding site; other site 512565018508 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512565018509 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512565018510 Walker A/P-loop; other site 512565018511 ATP binding site [chemical binding]; other site 512565018512 Q-loop/lid; other site 512565018513 ABC transporter signature motif; other site 512565018514 Walker B; other site 512565018515 D-loop; other site 512565018516 H-loop/switch region; other site 512565018517 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 512565018518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565018519 substrate binding pocket [chemical binding]; other site 512565018520 membrane-bound complex binding site; other site 512565018521 hinge residues; other site 512565018522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565018523 dimer interface [polypeptide binding]; other site 512565018524 conserved gate region; other site 512565018525 putative PBP binding loops; other site 512565018526 ABC-ATPase subunit interface; other site 512565018527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565018528 dimer interface [polypeptide binding]; other site 512565018529 conserved gate region; other site 512565018530 putative PBP binding loops; other site 512565018531 ABC-ATPase subunit interface; other site 512565018532 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 512565018533 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 512565018534 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565018535 Zn2+ binding site [ion binding]; other site 512565018536 Mg2+ binding site [ion binding]; other site 512565018537 recombination regulator RecX; Reviewed; Region: recX; PRK00117 512565018538 recombinase A; Provisional; Region: recA; PRK09354 512565018539 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 512565018540 hexamer interface [polypeptide binding]; other site 512565018541 Walker A motif; other site 512565018542 ATP binding site [chemical binding]; other site 512565018543 Walker B motif; other site 512565018544 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 512565018545 Fe-S cluster binding site [ion binding]; other site 512565018546 active site 512565018547 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565018548 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 512565018549 DNA-binding site [nucleotide binding]; DNA binding site 512565018550 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565018551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565018552 homodimer interface [polypeptide binding]; other site 512565018553 catalytic residue [active] 512565018554 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 512565018555 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565018556 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565018557 leucine export protein LeuE; Provisional; Region: PRK10958 512565018558 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565018559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565018560 active site 512565018561 ATP binding site [chemical binding]; other site 512565018562 substrate binding site [chemical binding]; other site 512565018563 activation loop (A-loop); other site 512565018564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565018565 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 512565018566 ATP binding site [chemical binding]; other site 512565018567 putative Mg++ binding site [ion binding]; other site 512565018568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565018569 nucleotide binding region [chemical binding]; other site 512565018570 ATP-binding site [chemical binding]; other site 512565018571 DEAD/H associated; Region: DEAD_assoc; pfam08494 512565018572 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 512565018573 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565018574 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 512565018575 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 512565018576 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 512565018577 putative DNA binding site [nucleotide binding]; other site 512565018578 catalytic residue [active] 512565018579 putative H2TH interface [polypeptide binding]; other site 512565018580 putative catalytic residues [active] 512565018581 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 512565018582 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512565018583 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 512565018584 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565018585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565018586 non-specific DNA binding site [nucleotide binding]; other site 512565018587 salt bridge; other site 512565018588 sequence-specific DNA binding site [nucleotide binding]; other site 512565018589 Competence-damaged protein; Region: CinA; pfam02464 512565018590 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 512565018591 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 512565018592 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 512565018593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565018594 FeS/SAM binding site; other site 512565018595 Predicted integral membrane protein [Function unknown]; Region: COG5542 512565018596 Predicted integral membrane protein [Function unknown]; Region: COG5542 512565018597 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565018598 dimerization interface [polypeptide binding]; other site 512565018599 putative DNA binding site [nucleotide binding]; other site 512565018600 Predicted transcriptional regulator [Transcription]; Region: COG2345 512565018601 putative Zn2+ binding site [ion binding]; other site 512565018602 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 512565018603 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 512565018604 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 512565018605 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565018606 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 512565018607 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 512565018608 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 512565018609 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 512565018610 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565018611 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 512565018612 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 512565018613 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 512565018614 dimer interface [polypeptide binding]; other site 512565018615 active site 512565018616 catalytic residue [active] 512565018617 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 512565018618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 512565018619 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 512565018620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512565018621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565018622 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 512565018623 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 512565018624 ligand binding site [chemical binding]; other site 512565018625 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565018626 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565018627 ligand binding site [chemical binding]; other site 512565018628 flexible hinge region; other site 512565018629 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 512565018630 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565018631 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565018632 ligand binding site [chemical binding]; other site 512565018633 flexible hinge region; other site 512565018634 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 512565018635 putative switch regulator; other site 512565018636 non-specific DNA interactions [nucleotide binding]; other site 512565018637 DNA binding site [nucleotide binding] 512565018638 sequence specific DNA binding site [nucleotide binding]; other site 512565018639 putative cAMP binding site [chemical binding]; other site 512565018640 Protein of unknown function, DUF393; Region: DUF393; pfam04134 512565018641 dihydrodipicolinate reductase; Provisional; Region: PRK00048 512565018642 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 512565018643 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 512565018644 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 512565018645 active site 512565018646 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512565018647 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 512565018648 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512565018649 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 512565018650 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 512565018651 RNase E interface [polypeptide binding]; other site 512565018652 trimer interface [polypeptide binding]; other site 512565018653 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 512565018654 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 512565018655 RNase E interface [polypeptide binding]; other site 512565018656 trimer interface [polypeptide binding]; other site 512565018657 active site 512565018658 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 512565018659 putative nucleic acid binding region [nucleotide binding]; other site 512565018660 G-X-X-G motif; other site 512565018661 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 512565018662 RNA binding site [nucleotide binding]; other site 512565018663 domain interface; other site 512565018664 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 512565018665 16S/18S rRNA binding site [nucleotide binding]; other site 512565018666 S13e-L30e interaction site [polypeptide binding]; other site 512565018667 25S rRNA binding site [nucleotide binding]; other site 512565018668 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 512565018669 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 512565018670 active site 512565018671 Riboflavin kinase; Region: Flavokinase; smart00904 512565018672 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 512565018673 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 512565018674 RNA binding site [nucleotide binding]; other site 512565018675 active site 512565018676 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 512565018677 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 512565018678 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 512565018679 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 512565018680 DHH family; Region: DHH; pfam01368 512565018681 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 512565018682 Protein of unknown function (DUF503); Region: DUF503; pfam04456 512565018683 Methyltransferase domain; Region: Methyltransf_26; pfam13659 512565018684 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 512565018685 translation initiation factor IF-2; Region: IF-2; TIGR00487 512565018686 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 512565018687 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 512565018688 G1 box; other site 512565018689 putative GEF interaction site [polypeptide binding]; other site 512565018690 GTP/Mg2+ binding site [chemical binding]; other site 512565018691 Switch I region; other site 512565018692 G2 box; other site 512565018693 G3 box; other site 512565018694 Switch II region; other site 512565018695 G4 box; other site 512565018696 G5 box; other site 512565018697 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 512565018698 Translation-initiation factor 2; Region: IF-2; pfam11987 512565018699 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 512565018700 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 512565018701 NusA N-terminal domain; Region: NusA_N; pfam08529 512565018702 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 512565018703 RNA binding site [nucleotide binding]; other site 512565018704 homodimer interface [polypeptide binding]; other site 512565018705 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 512565018706 G-X-X-G motif; other site 512565018707 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 512565018708 G-X-X-G motif; other site 512565018709 ribosome maturation protein RimP; Reviewed; Region: PRK00092 512565018710 Sm and related proteins; Region: Sm_like; cl00259 512565018711 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 512565018712 putative oligomer interface [polypeptide binding]; other site 512565018713 putative RNA binding site [nucleotide binding]; other site 512565018714 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 512565018715 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 512565018716 active site 512565018717 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 512565018718 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 512565018719 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 512565018720 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565018721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565018722 ATP binding site [chemical binding]; other site 512565018723 Mg2+ binding site [ion binding]; other site 512565018724 G-X-G motif; other site 512565018725 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 512565018726 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 512565018727 catalytic triad [active] 512565018728 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 512565018729 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 512565018730 catalytic triad [active] 512565018731 short chain dehydrogenase; Provisional; Region: PRK06057 512565018732 classical (c) SDRs; Region: SDR_c; cd05233 512565018733 NAD(P) binding site [chemical binding]; other site 512565018734 active site 512565018735 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565018736 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 512565018737 NAD(P) binding site [chemical binding]; other site 512565018738 catalytic residues [active] 512565018739 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 512565018740 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 512565018741 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 512565018742 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 512565018743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565018744 Histidine kinase; Region: HisKA_3; pfam07730 512565018745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565018746 ATP binding site [chemical binding]; other site 512565018747 Mg2+ binding site [ion binding]; other site 512565018748 G-X-G motif; other site 512565018749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565018750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018751 active site 512565018752 phosphorylation site [posttranslational modification] 512565018753 intermolecular recognition site; other site 512565018754 dimerization interface [polypeptide binding]; other site 512565018755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565018756 DNA binding residues [nucleotide binding] 512565018757 dimerization interface [polypeptide binding]; other site 512565018758 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 512565018759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565018760 Walker A/P-loop; other site 512565018761 ATP binding site [chemical binding]; other site 512565018762 Q-loop/lid; other site 512565018763 ABC transporter signature motif; other site 512565018764 Walker B; other site 512565018765 D-loop; other site 512565018766 H-loop/switch region; other site 512565018767 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 512565018768 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 512565018769 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 512565018770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565018771 Predicted membrane protein [Function unknown]; Region: COG1511 512565018772 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 512565018773 Predicted membrane protein [Function unknown]; Region: COG1511 512565018774 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 512565018775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565018776 Walker A/P-loop; other site 512565018777 ATP binding site [chemical binding]; other site 512565018778 Q-loop/lid; other site 512565018779 ABC transporter signature motif; other site 512565018780 Walker B; other site 512565018781 D-loop; other site 512565018782 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 512565018783 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 512565018784 GAF domain; Region: GAF_2; pfam13185 512565018785 GAF domain; Region: GAF_3; pfam13492 512565018786 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 512565018787 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565018788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565018789 ATP binding site [chemical binding]; other site 512565018790 Mg2+ binding site [ion binding]; other site 512565018791 G-X-G motif; other site 512565018792 GAF domain; Region: GAF; cl17456 512565018793 ANTAR domain; Region: ANTAR; pfam03861 512565018794 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565018795 anti sigma factor interaction site; other site 512565018796 regulatory phosphorylation site [posttranslational modification]; other site 512565018797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565018798 putative active site [active] 512565018799 heme pocket [chemical binding]; other site 512565018800 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565018801 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565018802 putative active site [active] 512565018803 heme pocket [chemical binding]; other site 512565018804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 512565018805 dimer interface [polypeptide binding]; other site 512565018806 phosphorylation site [posttranslational modification] 512565018807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565018808 ATP binding site [chemical binding]; other site 512565018809 Mg2+ binding site [ion binding]; other site 512565018810 G-X-G motif; other site 512565018811 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 512565018812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565018813 active site 512565018814 phosphorylation site [posttranslational modification] 512565018815 intermolecular recognition site; other site 512565018816 dimerization interface [polypeptide binding]; other site 512565018817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565018818 putative DNA binding site [nucleotide binding]; other site 512565018819 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565018820 putative Zn2+ binding site [ion binding]; other site 512565018821 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 512565018822 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565018823 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 512565018824 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 512565018825 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 512565018826 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 512565018827 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 512565018828 active site 512565018829 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 512565018830 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 512565018831 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 512565018832 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 512565018833 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 512565018834 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 512565018835 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 512565018836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565018837 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512565018838 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 512565018839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 512565018840 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 512565018841 iron-sulfur cluster [ion binding]; other site 512565018842 [2Fe-2S] cluster binding site [ion binding]; other site 512565018843 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565018844 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565018845 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 512565018846 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565018847 FeS/SAM binding site; other site 512565018848 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 512565018849 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 512565018850 ribosome recycling factor; Reviewed; Region: frr; PRK00083 512565018851 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 512565018852 hinge region; other site 512565018853 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 512565018854 putative nucleotide binding site [chemical binding]; other site 512565018855 uridine monophosphate binding site [chemical binding]; other site 512565018856 homohexameric interface [polypeptide binding]; other site 512565018857 elongation factor Ts; Provisional; Region: tsf; PRK09377 512565018858 UBA/TS-N domain; Region: UBA; pfam00627 512565018859 Elongation factor TS; Region: EF_TS; pfam00889 512565018860 Elongation factor TS; Region: EF_TS; pfam00889 512565018861 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 512565018862 rRNA interaction site [nucleotide binding]; other site 512565018863 S8 interaction site; other site 512565018864 putative laminin-1 binding site; other site 512565018865 hypothetical protein; Reviewed; Region: PRK12497 512565018866 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 512565018867 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 512565018868 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 512565018869 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 512565018870 DNA protecting protein DprA; Region: dprA; TIGR00732 512565018871 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 512565018872 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 512565018873 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 512565018874 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512565018875 active site 512565018876 DNA binding site [nucleotide binding] 512565018877 Int/Topo IB signature motif; other site 512565018878 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 512565018879 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565018880 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565018881 catalytic residue [active] 512565018882 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565018883 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 512565018884 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 512565018885 RNA/DNA hybrid binding site [nucleotide binding]; other site 512565018886 active site 512565018887 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512565018888 nudix motif; other site 512565018889 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 512565018890 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 512565018891 Catalytic site [active] 512565018892 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 512565018893 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 512565018894 Catalytic site [active] 512565018895 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 512565018896 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 512565018897 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 512565018898 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 512565018899 RimM N-terminal domain; Region: RimM; pfam01782 512565018900 PRC-barrel domain; Region: PRC; pfam05239 512565018901 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 512565018902 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 512565018903 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 512565018904 Protein of unknown function (DUF402); Region: DUF402; pfam04167 512565018905 prolyl-tRNA synthetase; Provisional; Region: PRK08661 512565018906 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 512565018907 dimer interface [polypeptide binding]; other site 512565018908 motif 1; other site 512565018909 active site 512565018910 motif 2; other site 512565018911 motif 3; other site 512565018912 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 512565018913 anticodon binding site; other site 512565018914 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565018915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565018916 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 512565018917 PQQ-like domain; Region: PQQ_2; pfam13360 512565018918 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565018919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565018920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565018921 DNA binding residues [nucleotide binding] 512565018922 PQQ-like domain; Region: PQQ_2; pfam13360 512565018923 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 512565018924 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565018925 active site 512565018926 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565018927 putative active site [active] 512565018928 signal recognition particle protein; Provisional; Region: PRK10867 512565018929 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 512565018930 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 512565018931 P loop; other site 512565018932 GTP binding site [chemical binding]; other site 512565018933 Signal peptide binding domain; Region: SRP_SPB; pfam02978 512565018934 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 512565018935 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 512565018936 TrkA-N domain; Region: TrkA_N; pfam02254 512565018937 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 512565018938 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 512565018939 GtrA-like protein; Region: GtrA; pfam04138 512565018940 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 512565018941 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 512565018942 Ligand binding site; other site 512565018943 Putative Catalytic site; other site 512565018944 DXD motif; other site 512565018945 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565018946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565018947 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 512565018948 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565018949 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565018950 active site 512565018951 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512565018952 Methyltransferase domain; Region: Methyltransf_24; pfam13578 512565018953 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512565018954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565018955 active site 512565018956 PII uridylyl-transferase; Provisional; Region: PRK03381 512565018957 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 512565018958 metal binding triad; other site 512565018959 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 512565018960 HD domain; Region: HD; pfam01966 512565018961 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 512565018962 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 512565018963 Nitrogen regulatory protein P-II; Region: P-II; smart00938 512565018964 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 512565018965 Phosphotransferase enzyme family; Region: APH; pfam01636 512565018966 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565018967 active site 512565018968 ATP binding site [chemical binding]; other site 512565018969 substrate binding site [chemical binding]; other site 512565018970 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 512565018971 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565018972 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 512565018973 putative active site [active] 512565018974 putative metal binding site [ion binding]; other site 512565018975 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512565018976 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565018977 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 512565018978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565018979 motif II; other site 512565018980 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 512565018981 AAA domain; Region: AAA_23; pfam13476 512565018982 Walker A/P-loop; other site 512565018983 ATP binding site [chemical binding]; other site 512565018984 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 512565018985 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 512565018986 ABC transporter signature motif; other site 512565018987 Walker B; other site 512565018988 D-loop; other site 512565018989 H-loop/switch region; other site 512565018990 Domain of unknown function (DUF3492); Region: DUF3492; pfam11997 512565018991 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565018992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565018993 Spherulation-specific family 4; Region: Spherulin4; pfam12138 512565018994 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 512565018995 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 512565018996 DNA binding site [nucleotide binding] 512565018997 catalytic residue [active] 512565018998 H2TH interface [polypeptide binding]; other site 512565018999 putative catalytic residues [active] 512565019000 turnover-facilitating residue; other site 512565019001 intercalation triad [nucleotide binding]; other site 512565019002 8OG recognition residue [nucleotide binding]; other site 512565019003 putative reading head residues; other site 512565019004 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 512565019005 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512565019006 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 512565019007 ribonuclease III; Reviewed; Region: rnc; PRK00102 512565019008 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 512565019009 dimerization interface [polypeptide binding]; other site 512565019010 active site 512565019011 metal binding site [ion binding]; metal-binding site 512565019012 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 512565019013 dsRNA binding site [nucleotide binding]; other site 512565019014 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 512565019015 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 512565019016 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 512565019017 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 512565019018 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 512565019019 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 512565019020 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 512565019021 active site 512565019022 (T/H)XGH motif; other site 512565019023 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 512565019024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565019025 S-adenosylmethionine binding site [chemical binding]; other site 512565019026 Protein of unknown function (DUF952); Region: DUF952; cl01393 512565019027 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 512565019028 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 512565019029 generic binding surface II; other site 512565019030 ssDNA binding site; other site 512565019031 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512565019032 ATP binding site [chemical binding]; other site 512565019033 putative Mg++ binding site [ion binding]; other site 512565019034 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512565019035 nucleotide binding region [chemical binding]; other site 512565019036 ATP-binding site [chemical binding]; other site 512565019037 DAK2 domain; Region: Dak2; pfam02734 512565019038 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 512565019039 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 512565019040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565019041 Coenzyme A binding pocket [chemical binding]; other site 512565019042 thiamine monophosphate kinase; Provisional; Region: PRK05731 512565019043 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 512565019044 ATP binding site [chemical binding]; other site 512565019045 dimerization interface [polypeptide binding]; other site 512565019046 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565019047 AsnC family; Region: AsnC_trans_reg; pfam01037 512565019048 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 512565019049 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 512565019050 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 512565019051 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 512565019052 cystathionine gamma-lyase; Validated; Region: PRK07582 512565019053 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565019054 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565019055 catalytic residue [active] 512565019056 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 512565019057 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 512565019058 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 512565019059 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565019060 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565019061 putative acyl-acceptor binding pocket; other site 512565019062 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 512565019063 polyphosphate kinase; Provisional; Region: PRK05443 512565019064 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 512565019065 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 512565019066 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 512565019067 putative domain interface [polypeptide binding]; other site 512565019068 putative active site [active] 512565019069 catalytic site [active] 512565019070 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 512565019071 putative domain interface [polypeptide binding]; other site 512565019072 putative active site [active] 512565019073 catalytic site [active] 512565019074 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 512565019075 active site 512565019076 Ap6A binding site [chemical binding]; other site 512565019077 nudix motif; other site 512565019078 metal binding site [ion binding]; metal-binding site 512565019079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565019080 catalytic core [active] 512565019081 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 512565019082 IHF dimer interface [polypeptide binding]; other site 512565019083 IHF - DNA interface [nucleotide binding]; other site 512565019084 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 512565019085 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 512565019086 substrate binding site [chemical binding]; other site 512565019087 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 512565019088 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 512565019089 substrate binding site [chemical binding]; other site 512565019090 ligand binding site [chemical binding]; other site 512565019091 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 512565019092 Transcriptional regulator [Transcription]; Region: IclR; COG1414 512565019093 Bacterial transcriptional regulator; Region: IclR; pfam01614 512565019094 AAA ATPase domain; Region: AAA_16; pfam13191 512565019095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565019096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565019097 DNA binding residues [nucleotide binding] 512565019098 dimerization interface [polypeptide binding]; other site 512565019099 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565019100 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512565019101 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 512565019102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512565019103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565019104 NmrA-like family; Region: NmrA; pfam05368 512565019105 NAD(P) binding site [chemical binding]; other site 512565019106 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 512565019107 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 512565019108 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 512565019109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565019110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565019111 non-specific DNA binding site [nucleotide binding]; other site 512565019112 salt bridge; other site 512565019113 sequence-specific DNA binding site [nucleotide binding]; other site 512565019114 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 512565019115 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512565019116 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565019117 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565019118 Walker A/P-loop; other site 512565019119 ATP binding site [chemical binding]; other site 512565019120 Q-loop/lid; other site 512565019121 ABC transporter signature motif; other site 512565019122 Walker B; other site 512565019123 D-loop; other site 512565019124 H-loop/switch region; other site 512565019125 hypothetical protein; Provisional; Region: PRK09256 512565019126 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512565019127 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 512565019128 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512565019129 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512565019130 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512565019131 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565019132 putative catalytic site [active] 512565019133 putative metal binding site [ion binding]; other site 512565019134 putative phosphate binding site [ion binding]; other site 512565019135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565019136 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512565019137 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 512565019138 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 512565019139 active site 512565019140 catalytic residues [active] 512565019141 metal binding site [ion binding]; metal-binding site 512565019142 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 512565019143 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 512565019144 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 512565019145 active site 512565019146 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 512565019147 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 512565019148 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 512565019149 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 512565019150 homodimer interface [polypeptide binding]; other site 512565019151 substrate-cofactor binding pocket; other site 512565019152 catalytic residue [active] 512565019153 tartrate dehydrogenase; Region: TTC; TIGR02089 512565019154 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 512565019155 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 512565019156 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 512565019157 ligand binding site [chemical binding]; other site 512565019158 NAD binding site [chemical binding]; other site 512565019159 dimerization interface [polypeptide binding]; other site 512565019160 catalytic site [active] 512565019161 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 512565019162 putative L-serine binding site [chemical binding]; other site 512565019163 ketol-acid reductoisomerase; Provisional; Region: PRK05479 512565019164 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 512565019165 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 512565019166 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 512565019167 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 512565019168 putative valine binding site [chemical binding]; other site 512565019169 dimer interface [polypeptide binding]; other site 512565019170 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 512565019171 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 512565019172 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 512565019173 PYR/PP interface [polypeptide binding]; other site 512565019174 dimer interface [polypeptide binding]; other site 512565019175 TPP binding site [chemical binding]; other site 512565019176 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 512565019177 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 512565019178 TPP-binding site [chemical binding]; other site 512565019179 dimer interface [polypeptide binding]; other site 512565019180 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565019181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565019182 metal binding site [ion binding]; metal-binding site 512565019183 active site 512565019184 I-site; other site 512565019185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565019186 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 512565019187 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 512565019188 nudix motif; other site 512565019189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512565019190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565019191 dimer interface [polypeptide binding]; other site 512565019192 conserved gate region; other site 512565019193 putative PBP binding loops; other site 512565019194 ABC-ATPase subunit interface; other site 512565019195 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512565019196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565019197 dimer interface [polypeptide binding]; other site 512565019198 conserved gate region; other site 512565019199 putative PBP binding loops; other site 512565019200 ABC-ATPase subunit interface; other site 512565019201 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512565019202 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512565019203 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565019204 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565019205 DNA binding site [nucleotide binding] 512565019206 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512565019207 ligand binding site [chemical binding]; other site 512565019208 dimerization interface [polypeptide binding]; other site 512565019209 PAS domain S-box; Region: sensory_box; TIGR00229 512565019210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565019211 putative active site [active] 512565019212 heme pocket [chemical binding]; other site 512565019213 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565019214 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565019215 metal binding site [ion binding]; metal-binding site 512565019216 active site 512565019217 I-site; other site 512565019218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565019219 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 512565019220 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 512565019221 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 512565019222 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565019223 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512565019224 active site 512565019225 metal binding site [ion binding]; metal-binding site 512565019226 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565019227 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565019228 putative sugar binding sites [chemical binding]; other site 512565019229 Q-X-W motif; other site 512565019230 Pectate lyase; Region: Pectate_lyase; pfam03211 512565019231 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 512565019232 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 512565019233 GatB domain; Region: GatB_Yqey; smart00845 512565019234 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 512565019235 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 512565019236 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 512565019237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565019238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565019239 active site 512565019240 I-site; other site 512565019241 metal binding site [ion binding]; metal-binding site 512565019242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565019243 Ligase N family; Region: LIGANc; smart00532 512565019244 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 512565019245 nucleotide binding pocket [chemical binding]; other site 512565019246 K-X-D-G motif; other site 512565019247 catalytic site [active] 512565019248 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 512565019249 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 512565019250 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 512565019251 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 512565019252 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 512565019253 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 512565019254 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 512565019255 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565019256 catalytic residue [active] 512565019257 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 512565019258 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 512565019259 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 512565019260 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 512565019261 Ligand binding site [chemical binding]; other site 512565019262 Electron transfer flavoprotein domain; Region: ETF; pfam01012 512565019263 Domain of unknown function (DUF202); Region: DUF202; cl09954 512565019264 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 512565019265 hypothetical protein; Provisional; Region: PRK05858 512565019266 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 512565019267 PYR/PP interface [polypeptide binding]; other site 512565019268 dimer interface [polypeptide binding]; other site 512565019269 TPP binding site [chemical binding]; other site 512565019270 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512565019271 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 512565019272 TPP-binding site; other site 512565019273 dimer interface [polypeptide binding]; other site 512565019274 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 512565019275 nucleotide binding site [chemical binding]; other site 512565019276 putative NEF/HSP70 interaction site [polypeptide binding]; other site 512565019277 SBD interface [polypeptide binding]; other site 512565019278 enoyl-CoA hydratase; Provisional; Region: PRK05862 512565019279 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565019280 substrate binding site [chemical binding]; other site 512565019281 oxyanion hole (OAH) forming residues; other site 512565019282 trimer interface [polypeptide binding]; other site 512565019283 Predicted membrane protein [Function unknown]; Region: COG4270 512565019284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 512565019285 dimer interface [polypeptide binding]; other site 512565019286 putative CheW interface [polypeptide binding]; other site 512565019287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512565019288 PAS fold; Region: PAS_3; pfam08447 512565019289 putative active site [active] 512565019290 heme pocket [chemical binding]; other site 512565019291 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512565019292 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 512565019293 substrate binding site [chemical binding]; other site 512565019294 dimer interface [polypeptide binding]; other site 512565019295 ATP binding site [chemical binding]; other site 512565019296 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512565019297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565019298 Walker A/P-loop; other site 512565019299 ATP binding site [chemical binding]; other site 512565019300 Q-loop/lid; other site 512565019301 ABC transporter signature motif; other site 512565019302 Walker B; other site 512565019303 D-loop; other site 512565019304 H-loop/switch region; other site 512565019305 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565019306 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565019307 nucleotide binding site [chemical binding]; other site 512565019308 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 512565019309 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 512565019310 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 512565019311 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 512565019312 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 512565019313 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 512565019314 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 512565019315 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 512565019316 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512565019317 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 512565019318 active site 512565019319 Mn binding site [ion binding]; other site 512565019320 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 512565019321 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 512565019322 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 512565019323 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512565019324 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565019325 Transcriptional regulator PadR-like family; Region: PadR; cl17335 512565019326 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 512565019327 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 512565019328 Walker A; other site 512565019329 putative acyltransferase; Provisional; Region: PRK05790 512565019330 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 512565019331 dimer interface [polypeptide binding]; other site 512565019332 active site 512565019333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512565019334 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 512565019335 dimer interface [polypeptide binding]; other site 512565019336 substrate binding site [chemical binding]; other site 512565019337 metal binding site [ion binding]; metal-binding site 512565019338 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512565019339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 512565019340 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 512565019341 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 512565019342 NAD(P) binding site [chemical binding]; other site 512565019343 catalytic residues [active] 512565019344 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 512565019345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565019346 Walker A/P-loop; other site 512565019347 ATP binding site [chemical binding]; other site 512565019348 Q-loop/lid; other site 512565019349 ABC transporter signature motif; other site 512565019350 Walker B; other site 512565019351 D-loop; other site 512565019352 H-loop/switch region; other site 512565019353 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 512565019354 hypothetical protein; Provisional; Region: PRK03298 512565019355 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 512565019356 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565019357 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 512565019358 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 512565019359 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 512565019360 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 512565019361 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 512565019362 hinge; other site 512565019363 active site 512565019364 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 512565019365 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 512565019366 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 512565019367 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 512565019368 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 512565019369 gamma subunit interface [polypeptide binding]; other site 512565019370 epsilon subunit interface [polypeptide binding]; other site 512565019371 LBP interface [polypeptide binding]; other site 512565019372 Transcriptional regulator [Transcription]; Region: LytR; COG1316 512565019373 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 512565019374 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512565019375 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 512565019376 alpha subunit interaction interface [polypeptide binding]; other site 512565019377 Walker A motif; other site 512565019378 ATP binding site [chemical binding]; other site 512565019379 Walker B motif; other site 512565019380 inhibitor binding site; inhibition site 512565019381 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512565019382 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 512565019383 core domain interface [polypeptide binding]; other site 512565019384 delta subunit interface [polypeptide binding]; other site 512565019385 epsilon subunit interface [polypeptide binding]; other site 512565019386 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 512565019387 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512565019388 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 512565019389 beta subunit interaction interface [polypeptide binding]; other site 512565019390 Walker A motif; other site 512565019391 ATP binding site [chemical binding]; other site 512565019392 Walker B motif; other site 512565019393 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512565019394 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 512565019395 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 512565019396 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 512565019397 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 512565019398 ATP synthase subunit C; Region: ATP-synt_C; cl00466 512565019399 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 512565019400 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 512565019401 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 512565019402 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 512565019403 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 512565019404 dimer interface [polypeptide binding]; other site 512565019405 active site 512565019406 glycine-pyridoxal phosphate binding site [chemical binding]; other site 512565019407 folate binding site [chemical binding]; other site 512565019408 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 512565019409 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 512565019410 putative NAD(P) binding site [chemical binding]; other site 512565019411 putative active site [active] 512565019412 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 512565019413 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 512565019414 Low molecular weight phosphatase family; Region: LMWPc; cl00105 512565019415 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 512565019416 active site 512565019417 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 512565019418 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 512565019419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565019420 S-adenosylmethionine binding site [chemical binding]; other site 512565019421 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565019422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565019423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565019424 metal binding site [ion binding]; metal-binding site 512565019425 active site 512565019426 I-site; other site 512565019427 PQQ-like domain; Region: PQQ_2; pfam13360 512565019428 PQQ-like domain; Region: PQQ_2; pfam13360 512565019429 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 512565019430 Trp docking motif [polypeptide binding]; other site 512565019431 active site 512565019432 peptide chain release factor 1; Validated; Region: prfA; PRK00591 512565019433 This domain is found in peptide chain release factors; Region: PCRF; smart00937 512565019434 RF-1 domain; Region: RF-1; pfam00472 512565019435 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 512565019436 RNA ligase; Region: RNA_lig_T4_1; pfam09511 512565019437 polynucleotide kinase; Provisional; Region: pseT; PHA02530 512565019438 hypothetical protein; Provisional; Region: PRK06762 512565019439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565019440 active site 512565019441 motif I; other site 512565019442 motif II; other site 512565019443 RNA ligase; Region: RNA_ligase; pfam09414 512565019444 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 512565019445 active site 512565019446 dimer interface [polypeptide binding]; other site 512565019447 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 512565019448 transcription termination factor Rho; Provisional; Region: PRK12608 512565019449 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 512565019450 RNA binding site [nucleotide binding]; other site 512565019451 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565019452 Walker A motif; other site 512565019453 ATP binding site [chemical binding]; other site 512565019454 Walker B motif; other site 512565019455 homoserine kinase; Provisional; Region: PRK01212 512565019456 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 512565019457 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565019458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565019459 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 512565019460 Protein export membrane protein; Region: SecD_SecF; cl14618 512565019461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512565019462 MarR family; Region: MarR; pfam01047 512565019463 Domain of unknown function (DUF305); Region: DUF305; pfam03713 512565019464 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 512565019465 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 512565019466 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 512565019467 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 512565019468 active site 512565019469 HIGH motif; other site 512565019470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565019471 KMSK motif region; other site 512565019472 tRNA binding surface [nucleotide binding]; other site 512565019473 anticodon binding site; other site 512565019474 DALR anticodon binding domain; Region: DALR_1; smart00836 512565019475 diaminopimelate decarboxylase; Region: lysA; TIGR01048 512565019476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 512565019477 active site 512565019478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512565019479 substrate binding site [chemical binding]; other site 512565019480 catalytic residues [active] 512565019481 dimer interface [polypeptide binding]; other site 512565019482 homoserine dehydrogenase; Provisional; Region: PRK06349 512565019483 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 512565019484 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 512565019485 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 512565019486 threonine synthase; Reviewed; Region: PRK06721 512565019487 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 512565019488 homodimer interface [polypeptide binding]; other site 512565019489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565019490 catalytic residue [active] 512565019491 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 512565019492 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 512565019493 glutaminase active site [active] 512565019494 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 512565019495 dimer interface [polypeptide binding]; other site 512565019496 active site 512565019497 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 512565019498 dimer interface [polypeptide binding]; other site 512565019499 active site 512565019500 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565019501 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 512565019502 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565019503 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 512565019504 DXD motif; other site 512565019505 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 512565019506 active site 512565019507 Tetratricopeptide repeat; Region: TPR_16; pfam13432 512565019508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565019509 TPR motif; other site 512565019510 binding surface 512565019511 Tetratricopeptide repeat; Region: TPR_16; pfam13432 512565019512 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 512565019513 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565019514 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565019515 active site 512565019516 ATP binding site [chemical binding]; other site 512565019517 substrate binding site [chemical binding]; other site 512565019518 activation loop (A-loop); other site 512565019519 SnoaL-like domain; Region: SnoaL_2; pfam12680 512565019520 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565019521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565019522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565019523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565019524 putative substrate translocation pore; other site 512565019525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565019526 hypothetical protein; Provisional; Region: PRK02237 512565019527 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565019528 anti sigma factor interaction site; other site 512565019529 regulatory phosphorylation site [posttranslational modification]; other site 512565019530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512565019531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565019532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565019533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565019534 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 512565019535 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565019536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565019537 NAD(P) binding site [chemical binding]; other site 512565019538 active site 512565019539 trehalose synthase; Region: treS_nterm; TIGR02456 512565019540 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 512565019541 active site 512565019542 catalytic site [active] 512565019543 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565019544 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565019545 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565019546 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565019547 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 512565019548 aromatic chitin/cellulose binding site residues [chemical binding]; other site 512565019549 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 512565019550 active site 512565019551 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 512565019552 aromatic chitin/cellulose binding site residues [chemical binding]; other site 512565019553 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 512565019554 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 512565019555 putative active site [active] 512565019556 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 512565019557 active site 512565019558 catalytic residues [active] 512565019559 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 512565019560 metal binding site [ion binding]; metal-binding site 512565019561 ligand binding site [chemical binding]; other site 512565019562 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 512565019563 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 512565019564 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565019565 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 512565019566 NodB motif; other site 512565019567 active site 512565019568 catalytic site [active] 512565019569 metal binding site [ion binding]; metal-binding site 512565019570 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 512565019571 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 512565019572 putative DNA binding site [nucleotide binding]; other site 512565019573 catalytic residue [active] 512565019574 putative H2TH interface [polypeptide binding]; other site 512565019575 putative catalytic residues [active] 512565019576 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 512565019577 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512565019578 Clp protease; Region: CLP_protease; pfam00574 512565019579 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 512565019580 oligomer interface [polypeptide binding]; other site 512565019581 active site residues [active] 512565019582 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 512565019583 Amidinotransferase; Region: Amidinotransf; cl12043 512565019584 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 512565019585 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 512565019586 inhibitor-cofactor binding pocket; inhibition site 512565019587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565019588 catalytic residue [active] 512565019589 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 512565019590 phosphopeptide binding site; other site 512565019591 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565019592 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 512565019593 putative acyl-acceptor binding pocket; other site 512565019594 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 512565019595 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 512565019596 nucleophile elbow; other site 512565019597 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 512565019598 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 512565019599 DNA binding residues [nucleotide binding] 512565019600 putative dimer interface [polypeptide binding]; other site 512565019601 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512565019602 catalytic residues [active] 512565019603 Transposase domain (DUF772); Region: DUF772; pfam05598 512565019604 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 512565019605 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 512565019606 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 512565019607 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 512565019608 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565019609 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 512565019610 protein binding site [polypeptide binding]; other site 512565019611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565019612 dimerization interface [polypeptide binding]; other site 512565019613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565019614 dimer interface [polypeptide binding]; other site 512565019615 phosphorylation site [posttranslational modification] 512565019616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565019617 ATP binding site [chemical binding]; other site 512565019618 Mg2+ binding site [ion binding]; other site 512565019619 G-X-G motif; other site 512565019620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565019621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565019622 active site 512565019623 phosphorylation site [posttranslational modification] 512565019624 intermolecular recognition site; other site 512565019625 dimerization interface [polypeptide binding]; other site 512565019626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565019627 DNA binding site [nucleotide binding] 512565019628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565019629 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565019630 putative acyl-acceptor binding pocket; other site 512565019631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 512565019632 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 512565019633 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 512565019634 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 512565019635 TPP-binding site [chemical binding]; other site 512565019636 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 512565019637 phosphate acetyltransferase; Reviewed; Region: PRK05632 512565019638 DRTGG domain; Region: DRTGG; pfam07085 512565019639 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 512565019640 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 512565019641 propionate/acetate kinase; Provisional; Region: PRK12379 512565019642 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512565019643 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 512565019644 NAD(P) binding site [chemical binding]; other site 512565019645 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 512565019646 Malic enzyme, N-terminal domain; Region: malic; pfam00390 512565019647 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 512565019648 NAD(P) binding pocket [chemical binding]; other site 512565019649 Predicted transcriptional regulator [Transcription]; Region: COG2932 512565019650 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 512565019651 Catalytic site [active] 512565019652 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 512565019653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565019654 Transcriptional regulators [Transcription]; Region: FadR; COG2186 512565019655 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565019656 DNA-binding site [nucleotide binding]; DNA binding site 512565019657 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 512565019658 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 512565019659 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 512565019660 KduI/IolB family; Region: KduI; cl01508 512565019661 Transcription factor WhiB; Region: Whib; pfam02467 512565019662 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 512565019663 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 512565019664 putative active site [active] 512565019665 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 512565019666 active site 512565019667 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 512565019668 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 512565019669 Active Sites [active] 512565019670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 512565019671 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 512565019672 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 512565019673 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 512565019674 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 512565019675 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 512565019676 PAS fold; Region: PAS_4; pfam08448 512565019677 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 512565019678 Histidine kinase; Region: HisKA_2; pfam07568 512565019679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565019680 ATP binding site [chemical binding]; other site 512565019681 Mg2+ binding site [ion binding]; other site 512565019682 G-X-G motif; other site 512565019683 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 512565019684 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 512565019685 dimer interface [polypeptide binding]; other site 512565019686 active site 512565019687 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 512565019688 dimer interface [polypeptide binding]; other site 512565019689 active site 512565019690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 512565019691 TPR motif; other site 512565019692 binding surface 512565019693 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 512565019694 carboxyltransferase (CT) interaction site; other site 512565019695 biotinylation site [posttranslational modification]; other site 512565019696 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 512565019697 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 512565019698 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565019699 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565019700 DNA binding residues [nucleotide binding] 512565019701 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 512565019702 Transcription factor WhiB; Region: Whib; pfam02467 512565019703 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 512565019704 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 512565019705 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 512565019706 hinge; other site 512565019707 active site 512565019708 Predicted GTPases [General function prediction only]; Region: COG1162 512565019709 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 512565019710 GTPase/Zn-binding domain interface [polypeptide binding]; other site 512565019711 GTP/Mg2+ binding site [chemical binding]; other site 512565019712 G4 box; other site 512565019713 G1 box; other site 512565019714 Switch I region; other site 512565019715 G2 box; other site 512565019716 G3 box; other site 512565019717 Switch II region; other site 512565019718 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 512565019719 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512565019720 active site 512565019721 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565019722 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 512565019723 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 512565019724 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 512565019725 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 512565019726 active site 512565019727 catalytic residues [active] 512565019728 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 512565019729 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 512565019730 putative sugar binding sites [chemical binding]; other site 512565019731 Q-X-W motif; other site 512565019732 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512565019733 sugar binding site [chemical binding]; other site 512565019734 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 512565019735 catalytic residue [active] 512565019736 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 512565019737 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 512565019738 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 512565019739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 512565019740 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 512565019741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565019742 S-adenosylmethionine binding site [chemical binding]; other site 512565019743 short chain dehydrogenase; Provisional; Region: PRK07576 512565019744 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 512565019745 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 512565019746 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 512565019747 hypothetical protein; Validated; Region: PRK00068 512565019748 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 512565019749 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 512565019750 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 512565019751 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 512565019752 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 512565019753 Protein of unknown function DUF45; Region: DUF45; pfam01863 512565019754 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 512565019755 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 512565019756 ABC1 family; Region: ABC1; cl17513 512565019757 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512565019758 active site 512565019759 ATP binding site [chemical binding]; other site 512565019760 Transcription factor WhiB; Region: Whib; pfam02467 512565019761 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 512565019762 Part of AAA domain; Region: AAA_19; pfam13245 512565019763 Family description; Region: UvrD_C_2; pfam13538 512565019764 HRDC domain; Region: HRDC; pfam00570 512565019765 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 512565019766 catalytic residues [active] 512565019767 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 512565019768 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 512565019769 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 512565019770 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 512565019771 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 512565019772 putative NADH binding site [chemical binding]; other site 512565019773 putative active site [active] 512565019774 nudix motif; other site 512565019775 putative metal binding site [ion binding]; other site 512565019776 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512565019777 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 512565019778 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512565019779 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512565019780 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 512565019781 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512565019782 Rrf2 family protein; Region: rrf2_super; TIGR00738 512565019783 Transcriptional regulator; Region: Rrf2; pfam02082 512565019784 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 512565019785 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512565019786 substrate binding pocket [chemical binding]; other site 512565019787 membrane-bound complex binding site; other site 512565019788 hinge residues; other site 512565019789 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512565019790 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512565019791 Walker A/P-loop; other site 512565019792 ATP binding site [chemical binding]; other site 512565019793 Q-loop/lid; other site 512565019794 ABC transporter signature motif; other site 512565019795 Walker B; other site 512565019796 D-loop; other site 512565019797 H-loop/switch region; other site 512565019798 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512565019799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565019800 dimer interface [polypeptide binding]; other site 512565019801 conserved gate region; other site 512565019802 putative PBP binding loops; other site 512565019803 ABC-ATPase subunit interface; other site 512565019804 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512565019805 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565019806 putative acyl-acceptor binding pocket; other site 512565019807 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 512565019808 DNA-binding site [nucleotide binding]; DNA binding site 512565019809 RNA-binding motif; other site 512565019810 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512565019811 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512565019812 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 512565019813 Part of AAA domain; Region: AAA_19; pfam13245 512565019814 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512565019815 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512565019816 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 512565019817 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 512565019818 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 512565019819 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 512565019820 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 512565019821 metal binding site [ion binding]; metal-binding site 512565019822 putative dimer interface [polypeptide binding]; other site 512565019823 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 512565019824 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 512565019825 putative trimer interface [polypeptide binding]; other site 512565019826 putative CoA binding site [chemical binding]; other site 512565019827 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 512565019828 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565019829 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565019830 dimerization interface [polypeptide binding]; other site 512565019831 LysE type translocator; Region: LysE; cl00565 512565019832 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 512565019833 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565019834 DNA binding residues [nucleotide binding] 512565019835 drug binding residues [chemical binding]; other site 512565019836 dimer interface [polypeptide binding]; other site 512565019837 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 512565019838 beta-clamp/clamp loader binding surface; other site 512565019839 beta-clamp/translesion DNA polymerase binding surface; other site 512565019840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512565019841 short chain dehydrogenase; Provisional; Region: PRK07109 512565019842 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 512565019843 putative NAD(P) binding site [chemical binding]; other site 512565019844 active site 512565019845 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 512565019846 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 512565019847 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 512565019848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565019849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565019850 homodimer interface [polypeptide binding]; other site 512565019851 catalytic residue [active] 512565019852 Ferredoxin [Energy production and conversion]; Region: COG1146 512565019853 4Fe-4S binding domain; Region: Fer4; pfam00037 512565019854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565019855 Coenzyme A binding pocket [chemical binding]; other site 512565019856 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 512565019857 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 512565019858 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565019859 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565019860 putative active site [active] 512565019861 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 512565019862 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 512565019863 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 512565019864 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 512565019865 L-aspartate oxidase; Provisional; Region: PRK06175 512565019866 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 512565019867 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 512565019868 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 512565019869 catalytic loop [active] 512565019870 iron binding site [ion binding]; other site 512565019871 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 512565019872 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565019873 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512565019874 Walker A/P-loop; other site 512565019875 ATP binding site [chemical binding]; other site 512565019876 Q-loop/lid; other site 512565019877 ABC transporter signature motif; other site 512565019878 Walker B; other site 512565019879 D-loop; other site 512565019880 H-loop/switch region; other site 512565019881 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512565019882 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512565019883 Walker A/P-loop; other site 512565019884 ATP binding site [chemical binding]; other site 512565019885 Q-loop/lid; other site 512565019886 ABC transporter signature motif; other site 512565019887 Walker B; other site 512565019888 D-loop; other site 512565019889 H-loop/switch region; other site 512565019890 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512565019891 TM-ABC transporter signature motif; other site 512565019892 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 512565019893 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 512565019894 TM-ABC transporter signature motif; other site 512565019895 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512565019896 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 512565019897 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 512565019898 classical (c) SDRs; Region: SDR_c; cd05233 512565019899 NAD(P) binding site [chemical binding]; other site 512565019900 active site 512565019901 short chain dehydrogenase; Provisional; Region: PRK05650 512565019902 classical (c) SDRs; Region: SDR_c; cd05233 512565019903 NAD(P) binding site [chemical binding]; other site 512565019904 active site 512565019905 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 512565019906 Phosphotransferase enzyme family; Region: APH; pfam01636 512565019907 putative active site [active] 512565019908 putative substrate binding site [chemical binding]; other site 512565019909 ATP binding site [chemical binding]; other site 512565019910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565019911 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565019912 active site 512565019913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565019914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565019915 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 512565019916 putative active site [active] 512565019917 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512565019918 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512565019919 DNA-binding site [nucleotide binding]; DNA binding site 512565019920 UTRA domain; Region: UTRA; pfam07702 512565019921 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 512565019922 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 512565019923 NAD binding site [chemical binding]; other site 512565019924 catalytic Zn binding site [ion binding]; other site 512565019925 substrate binding site [chemical binding]; other site 512565019926 structural Zn binding site [ion binding]; other site 512565019927 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 512565019928 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565019929 NAD binding site [chemical binding]; other site 512565019930 catalytic residues [active] 512565019931 tetracycline repressor protein TetR; Provisional; Region: PRK13756 512565019932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565019933 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565019934 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 512565019935 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 512565019936 acyl-activating enzyme (AAE) consensus motif; other site 512565019937 putative AMP binding site [chemical binding]; other site 512565019938 putative active site [active] 512565019939 putative CoA binding site [chemical binding]; other site 512565019940 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 512565019941 active site 512565019942 8-oxo-dGMP binding site [chemical binding]; other site 512565019943 nudix motif; other site 512565019944 metal binding site [ion binding]; metal-binding site 512565019945 Pleckstrin homology-like domain; Region: PH-like; cl17171 512565019946 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 512565019947 active site pocket [active] 512565019948 oxyanion hole [active] 512565019949 catalytic triad [active] 512565019950 active site nucleophile [active] 512565019951 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 512565019952 metal binding triad [ion binding]; metal-binding site 512565019953 G5 domain; Region: G5; pfam07501 512565019954 MarR family; Region: MarR; pfam01047 512565019955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565019956 Coenzyme A binding pocket [chemical binding]; other site 512565019957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565019958 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 512565019959 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 512565019960 putative active site [active] 512565019961 GTP-binding protein YchF; Reviewed; Region: PRK09601 512565019962 YchF GTPase; Region: YchF; cd01900 512565019963 G1 box; other site 512565019964 GTP/Mg2+ binding site [chemical binding]; other site 512565019965 Switch I region; other site 512565019966 G2 box; other site 512565019967 Switch II region; other site 512565019968 G3 box; other site 512565019969 G4 box; other site 512565019970 G5 box; other site 512565019971 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 512565019972 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565019973 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 512565019974 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 512565019975 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 512565019976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512565019977 AlkA N-terminal domain; Region: AlkA_N; pfam06029 512565019978 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 512565019979 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 512565019980 helix-hairpin-helix signature motif; other site 512565019981 substrate binding pocket [chemical binding]; other site 512565019982 active site 512565019983 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 512565019984 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 512565019985 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 512565019986 active site 512565019987 DNA binding site [nucleotide binding] 512565019988 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 512565019989 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565019990 active site 512565019991 HIGH motif; other site 512565019992 nucleotide binding site [chemical binding]; other site 512565019993 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565019994 active site 512565019995 KMSKS motif; other site 512565019996 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 512565019997 tRNA binding surface [nucleotide binding]; other site 512565019998 anticodon binding site; other site 512565019999 RmuC family; Region: RmuC; pfam02646 512565020000 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 512565020001 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 512565020002 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 512565020003 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 512565020004 generic binding surface II; other site 512565020005 generic binding surface I; other site 512565020006 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 512565020007 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 512565020008 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 512565020009 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 512565020010 putative active site [active] 512565020011 Rhomboid family; Region: Rhomboid; pfam01694 512565020012 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 512565020013 cleavage site 512565020014 active site 512565020015 substrate binding sites [chemical binding]; other site 512565020016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 512565020017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 512565020018 catalytic residue [active] 512565020019 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 512565020020 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 512565020021 putative active site [active] 512565020022 PhoH-like protein; Region: PhoH; pfam02562 512565020023 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 512565020024 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 512565020025 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 512565020026 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 512565020027 catalytic residue [active] 512565020028 putative FPP diphosphate binding site; other site 512565020029 putative FPP binding hydrophobic cleft; other site 512565020030 dimer interface [polypeptide binding]; other site 512565020031 putative IPP diphosphate binding site; other site 512565020032 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 512565020033 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 512565020034 active site 512565020035 substrate-binding site [chemical binding]; other site 512565020036 metal-binding site [ion binding] 512565020037 GTP binding site [chemical binding]; other site 512565020038 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512565020039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565020040 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565020041 DNA binding residues [nucleotide binding] 512565020042 Putative zinc-finger; Region: zf-HC2; pfam13490 512565020043 Predicted membrane protein [Function unknown]; Region: COG2246 512565020044 GtrA-like protein; Region: GtrA; pfam04138 512565020045 Predicted membrane protein [Function unknown]; Region: COG2246 512565020046 GtrA-like protein; Region: GtrA; pfam04138 512565020047 Bacterial PH domain; Region: DUF304; pfam03703 512565020048 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 512565020049 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 512565020050 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 512565020051 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 512565020052 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 512565020053 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 512565020054 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 512565020055 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565020056 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565020057 active site 512565020058 ATP binding site [chemical binding]; other site 512565020059 substrate binding site [chemical binding]; other site 512565020060 activation loop (A-loop); other site 512565020061 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 512565020062 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 512565020063 active site 512565020064 dimer interface [polypeptide binding]; other site 512565020065 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 512565020066 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512565020067 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 512565020068 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 512565020069 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 512565020070 carboxyltransferase (CT) interaction site; other site 512565020071 biotinylation site [posttranslational modification]; other site 512565020072 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 512565020073 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512565020074 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 512565020075 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565020076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565020077 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512565020078 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 512565020079 putative active site pocket [active] 512565020080 dimerization interface [polypeptide binding]; other site 512565020081 putative catalytic residue [active] 512565020082 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 512565020083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565020084 Coenzyme A binding pocket [chemical binding]; other site 512565020085 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512565020086 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 512565020087 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 512565020088 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 512565020089 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 512565020090 metal binding site [ion binding]; metal-binding site 512565020091 putative dimer interface [polypeptide binding]; other site 512565020092 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 512565020093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565020094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565020095 active site 512565020096 ATP binding site [chemical binding]; other site 512565020097 substrate binding site [chemical binding]; other site 512565020098 activation loop (A-loop); other site 512565020099 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 512565020100 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 512565020101 active site 512565020102 substrate binding site [chemical binding]; other site 512565020103 metal binding site [ion binding]; metal-binding site 512565020104 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 512565020105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512565020106 active site 512565020107 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 512565020108 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 512565020109 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 512565020110 putative active site [active] 512565020111 nucleotide binding site [chemical binding]; other site 512565020112 nudix motif; other site 512565020113 putative metal binding site [ion binding]; other site 512565020114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565020115 active site 512565020116 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 512565020117 intersubunit interface [polypeptide binding]; other site 512565020118 active site 512565020119 catalytic residue [active] 512565020120 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 512565020121 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 512565020122 NAD(P) binding site [chemical binding]; other site 512565020123 catalytic residues [active] 512565020124 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512565020125 NAD(P) binding site [chemical binding]; other site 512565020126 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 512565020127 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 512565020128 G1 box; other site 512565020129 GTP/Mg2+ binding site [chemical binding]; other site 512565020130 G2 box; other site 512565020131 Switch I region; other site 512565020132 G3 box; other site 512565020133 Switch II region; other site 512565020134 G4 box; other site 512565020135 G5 box; other site 512565020136 Protein of unknown function (DUF742); Region: DUF742; pfam05331 512565020137 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 512565020138 Nitrate and nitrite sensing; Region: NIT; pfam08376 512565020139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565020140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565020141 ATP binding site [chemical binding]; other site 512565020142 Mg2+ binding site [ion binding]; other site 512565020143 G-X-G motif; other site 512565020144 adenosine deaminase; Provisional; Region: PRK09358 512565020145 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 512565020146 active site 512565020147 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 512565020148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512565020149 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 512565020150 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 512565020151 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 512565020152 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 512565020153 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 512565020154 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 512565020155 active site 512565020156 catalytic motif [active] 512565020157 Zn binding site [ion binding]; other site 512565020158 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 512565020159 TM-ABC transporter signature motif; other site 512565020160 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512565020161 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 512565020162 TM-ABC transporter signature motif; other site 512565020163 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 512565020164 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512565020165 Walker A/P-loop; other site 512565020166 ATP binding site [chemical binding]; other site 512565020167 Q-loop/lid; other site 512565020168 ABC transporter signature motif; other site 512565020169 Walker B; other site 512565020170 D-loop; other site 512565020171 H-loop/switch region; other site 512565020172 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512565020173 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 512565020174 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 512565020175 ligand binding site [chemical binding]; other site 512565020176 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 512565020177 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 512565020178 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 512565020179 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 512565020180 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 512565020181 active site 512565020182 HIGH motif; other site 512565020183 dimer interface [polypeptide binding]; other site 512565020184 KMSKS motif; other site 512565020185 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 512565020186 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 512565020187 NAD binding site [chemical binding]; other site 512565020188 homodimer interface [polypeptide binding]; other site 512565020189 active site 512565020190 substrate binding site [chemical binding]; other site 512565020191 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 512565020192 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 512565020193 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 512565020194 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 512565020195 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565020196 Mg2+ binding site [ion binding]; other site 512565020197 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 512565020198 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 512565020199 CysD dimerization site [polypeptide binding]; other site 512565020200 G1 box; other site 512565020201 putative GEF interaction site [polypeptide binding]; other site 512565020202 GTP/Mg2+ binding site [chemical binding]; other site 512565020203 Switch I region; other site 512565020204 G2 box; other site 512565020205 G3 box; other site 512565020206 Switch II region; other site 512565020207 G4 box; other site 512565020208 G5 box; other site 512565020209 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 512565020210 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 512565020211 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 512565020212 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 512565020213 Active Sites [active] 512565020214 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512565020215 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 512565020216 active site 512565020217 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 512565020218 Bacterial sugar transferase; Region: Bac_transf; pfam02397 512565020219 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 512565020220 putative active site [active] 512565020221 catalytic residue [active] 512565020222 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 512565020223 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 512565020224 5S rRNA interface [nucleotide binding]; other site 512565020225 CTC domain interface [polypeptide binding]; other site 512565020226 L16 interface [polypeptide binding]; other site 512565020227 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 512565020228 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 512565020229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565020230 active site 512565020231 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 512565020232 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 512565020233 Substrate binding site; other site 512565020234 Mg++ binding site; other site 512565020235 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 512565020236 active site 512565020237 substrate binding site [chemical binding]; other site 512565020238 CoA binding site [chemical binding]; other site 512565020239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565020240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565020241 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512565020242 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565020243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512565020244 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 512565020245 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 512565020246 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 512565020247 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 512565020248 active site 512565020249 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 512565020250 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 512565020251 active site 512565020252 HIGH motif; other site 512565020253 KMSKS motif; other site 512565020254 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 512565020255 tRNA binding surface [nucleotide binding]; other site 512565020256 anticodon binding site; other site 512565020257 Predicted methyltransferases [General function prediction only]; Region: COG0313 512565020258 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 512565020259 putative SAM binding site [chemical binding]; other site 512565020260 putative homodimer interface [polypeptide binding]; other site 512565020261 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 512565020262 potential frameshift: common BLAST hit: gi|284033441|ref|YP_003383372.1| XRE family transcriptional regulator 512565020263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565020264 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565020265 non-specific DNA binding site [nucleotide binding]; other site 512565020266 salt bridge; other site 512565020267 sequence-specific DNA binding site [nucleotide binding]; other site 512565020268 HD domain; Region: HD_3; pfam13023 512565020269 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512565020270 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 512565020271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512565020272 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 512565020273 DXD motif; other site 512565020274 GAF domain; Region: GAF; pfam01590 512565020275 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565020276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565020277 ATP binding site [chemical binding]; other site 512565020278 Mg2+ binding site [ion binding]; other site 512565020279 G-X-G motif; other site 512565020280 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 512565020281 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565020282 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565020283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565020284 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 512565020285 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 512565020286 dimer interface [polypeptide binding]; other site 512565020287 putative functional site; other site 512565020288 putative MPT binding site; other site 512565020289 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 512565020290 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 512565020291 active site 512565020292 tetramer interface; other site 512565020293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565020294 dimerization interface [polypeptide binding]; other site 512565020295 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 512565020296 GAF domain; Region: GAF_3; pfam13492 512565020297 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565020298 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565020299 metal binding site [ion binding]; metal-binding site 512565020300 active site 512565020301 I-site; other site 512565020302 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 512565020303 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 512565020304 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 512565020305 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512565020306 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 512565020307 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 512565020308 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 512565020309 active site 512565020310 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 512565020311 Bacterial PH domain; Region: DUF304; pfam03703 512565020312 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 512565020313 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512565020314 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512565020315 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512565020316 catalytic residues [active] 512565020317 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 512565020318 protein-splicing catalytic site; other site 512565020319 thioester formation/cholesterol transfer; other site 512565020320 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 512565020321 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 512565020322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565020323 CoA binding domain; Region: CoA_binding_2; pfam13380 512565020324 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565020325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565020326 NAD(P) binding site [chemical binding]; other site 512565020327 active site 512565020328 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 512565020329 EamA-like transporter family; Region: EamA; pfam00892 512565020330 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 512565020331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512565020332 motif II; other site 512565020333 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 512565020334 MgtE intracellular N domain; Region: MgtE_N; smart00924 512565020335 FOG: CBS domain [General function prediction only]; Region: COG0517 512565020336 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 512565020337 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 512565020338 Domain of unknown function DUF59; Region: DUF59; pfam01883 512565020339 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 512565020340 sec-independent translocase; Provisional; Region: PRK01371 512565020341 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 512565020342 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565020343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 512565020344 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 512565020345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565020346 S-adenosylmethionine binding site [chemical binding]; other site 512565020347 multifunctional aminopeptidase A; Provisional; Region: PRK00913 512565020348 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 512565020349 interface (dimer of trimers) [polypeptide binding]; other site 512565020350 Substrate-binding/catalytic site; other site 512565020351 Zn-binding sites [ion binding]; other site 512565020352 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 512565020353 PaaX-like protein; Region: PaaX; pfam07848 512565020354 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 512565020355 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 512565020356 enoyl-CoA hydratase; Provisional; Region: PRK06688 512565020357 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512565020358 substrate binding site [chemical binding]; other site 512565020359 oxyanion hole (OAH) forming residues; other site 512565020360 trimer interface [polypeptide binding]; other site 512565020361 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cl10037 512565020362 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 512565020363 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 512565020364 hydrophobic ligand binding site; other site 512565020365 DivIVA domain; Region: DivI1A_domain; TIGR03544 512565020366 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 512565020367 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 512565020368 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 512565020369 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 512565020370 dimer interface [polypeptide binding]; other site 512565020371 PYR/PP interface [polypeptide binding]; other site 512565020372 TPP binding site [chemical binding]; other site 512565020373 substrate binding site [chemical binding]; other site 512565020374 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 512565020375 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 512565020376 TPP-binding site [chemical binding]; other site 512565020377 Ion channel; Region: Ion_trans_2; pfam07885 512565020378 TrkA-N domain; Region: TrkA_N; pfam02254 512565020379 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 512565020380 cyclase homology domain; Region: CHD; cd07302 512565020381 nucleotidyl binding site; other site 512565020382 metal binding site [ion binding]; metal-binding site 512565020383 dimer interface [polypeptide binding]; other site 512565020384 Predicted ATPase [General function prediction only]; Region: COG3903 512565020385 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 512565020386 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 512565020387 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 512565020388 N-acetyl-D-glucosamine binding site [chemical binding]; other site 512565020389 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 512565020390 dimer interface [polypeptide binding]; other site 512565020391 active site 512565020392 Schiff base residues; other site 512565020393 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 512565020394 active site 512565020395 homodimer interface [polypeptide binding]; other site 512565020396 SAM binding site [chemical binding]; other site 512565020397 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 512565020398 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 512565020399 active site 512565020400 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 512565020401 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 512565020402 domain interfaces; other site 512565020403 active site 512565020404 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 512565020405 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 512565020406 tRNA; other site 512565020407 putative tRNA binding site [nucleotide binding]; other site 512565020408 putative NADP binding site [chemical binding]; other site 512565020409 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 512565020410 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 512565020411 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 512565020412 CoA binding domain; Region: CoA_binding; smart00881 512565020413 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 512565020414 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 512565020415 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 512565020416 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 512565020417 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 512565020418 acyl-activating enzyme (AAE) consensus motif; other site 512565020419 AMP binding site [chemical binding]; other site 512565020420 active site 512565020421 CoA binding site [chemical binding]; other site 512565020422 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 512565020423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565020424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565020425 DNA binding residues [nucleotide binding] 512565020426 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512565020427 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 512565020428 putative acyl-acceptor binding pocket; other site 512565020429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565020430 NAD(P) binding site [chemical binding]; other site 512565020431 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 512565020432 active site 512565020433 DNA binding domain, excisionase family; Region: excise; TIGR01764 512565020434 Proline dehydrogenase; Region: Pro_dh; cl03282 512565020435 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 512565020436 CGNR zinc finger; Region: zf-CGNR; pfam11706 512565020437 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 512565020438 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565020439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565020440 active site 512565020441 phosphorylation site [posttranslational modification] 512565020442 intermolecular recognition site; other site 512565020443 dimerization interface [polypeptide binding]; other site 512565020444 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565020445 DNA binding site [nucleotide binding] 512565020446 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512565020447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565020448 dimer interface [polypeptide binding]; other site 512565020449 phosphorylation site [posttranslational modification] 512565020450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565020451 ATP binding site [chemical binding]; other site 512565020452 Mg2+ binding site [ion binding]; other site 512565020453 G-X-G motif; other site 512565020454 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 512565020455 PhoU domain; Region: PhoU; pfam01895 512565020456 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512565020457 catalytic core [active] 512565020458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565020459 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565020460 putative substrate translocation pore; other site 512565020461 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 512565020462 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 512565020463 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 512565020464 putative ADP-binding pocket [chemical binding]; other site 512565020465 malonic semialdehyde reductase; Provisional; Region: PRK10538 512565020466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565020467 NAD(P) binding site [chemical binding]; other site 512565020468 active site 512565020469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565020470 Response regulator receiver domain; Region: Response_reg; pfam00072 512565020471 active site 512565020472 phosphorylation site [posttranslational modification] 512565020473 intermolecular recognition site; other site 512565020474 dimerization interface [polypeptide binding]; other site 512565020475 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 512565020476 calcium binding site 2 [ion binding]; other site 512565020477 active site 512565020478 catalytic triad [active] 512565020479 calcium binding site 1 [ion binding]; other site 512565020480 PAS domain S-box; Region: sensory_box; TIGR00229 512565020481 PAS domain; Region: PAS_8; pfam13188 512565020482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565020483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565020484 ATP binding site [chemical binding]; other site 512565020485 Mg2+ binding site [ion binding]; other site 512565020486 G-X-G motif; other site 512565020487 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 512565020488 putative hydrophobic ligand binding site [chemical binding]; other site 512565020489 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565020490 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565020491 carbon storage regulator; Provisional; Region: PRK01712 512565020492 FliW protein; Region: FliW; pfam02623 512565020493 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 512565020494 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 512565020495 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 512565020496 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 512565020497 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 512565020498 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 512565020499 FlgN protein; Region: FlgN; pfam05130 512565020500 flagellin; Reviewed; Region: PRK08869 512565020501 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 512565020502 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 512565020503 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 512565020504 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 512565020505 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 512565020506 Flagellar protein FliS; Region: FliS; cl00654 512565020507 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 512565020508 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 512565020509 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 512565020510 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 512565020511 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 512565020512 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 512565020513 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 512565020514 FliG C-terminal domain; Region: FliG_C; pfam01706 512565020515 Flagellar assembly protein FliH; Region: FliH; pfam02108 512565020516 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 512565020517 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 512565020518 Walker A motif/ATP binding site; other site 512565020519 Walker B motif; other site 512565020520 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 512565020521 NlpC/P60 family; Region: NLPC_P60; pfam00877 512565020522 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 512565020523 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 512565020524 N-acetyl-D-glucosamine binding site [chemical binding]; other site 512565020525 catalytic residue [active] 512565020526 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 512565020527 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 512565020528 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 512565020529 FHIPEP family; Region: FHIPEP; pfam00771 512565020530 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 512565020531 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 512565020532 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 512565020533 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 512565020534 flagellar motor switch protein FliN; Region: fliN; TIGR02480 512565020535 Flagellar motor switch protein FliM; Region: FliM; pfam02154 512565020536 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 512565020537 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 512565020538 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 512565020539 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 512565020540 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 512565020541 ligand binding site [chemical binding]; other site 512565020542 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 512565020543 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 512565020544 Flagellar protein (FlbD); Region: FlbD; pfam06289 512565020545 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 512565020546 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 512565020547 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 512565020548 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 512565020549 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 512565020550 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 512565020551 Response regulator receiver domain; Region: Response_reg; pfam00072 512565020552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565020553 active site 512565020554 phosphorylation site [posttranslational modification] 512565020555 intermolecular recognition site; other site 512565020556 dimerization interface [polypeptide binding]; other site 512565020557 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 512565020558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565020559 Response regulator receiver domain; Region: Response_reg; pfam00072 512565020560 active site 512565020561 phosphorylation site [posttranslational modification] 512565020562 intermolecular recognition site; other site 512565020563 dimerization interface [polypeptide binding]; other site 512565020564 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 512565020565 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 512565020566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565020567 S-adenosylmethionine binding site [chemical binding]; other site 512565020568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565020569 active site 512565020570 phosphorylation site [posttranslational modification] 512565020571 intermolecular recognition site; other site 512565020572 dimerization interface [polypeptide binding]; other site 512565020573 CheB methylesterase; Region: CheB_methylest; pfam01339 512565020574 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 512565020575 potential frameshift: common BLAST hit: gi|256376451|ref|YP_003100111.1| CheA signal transduction histidine kinase 512565020576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 512565020577 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 512565020578 CheW-like domain; Region: CheW; pfam01584 512565020579 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 512565020580 putative binding surface; other site 512565020581 active site 512565020582 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 512565020583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565020584 Mg2+ binding site [ion binding]; other site 512565020585 G-X-G motif; other site 512565020586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565020587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565020588 active site 512565020589 phosphorylation site [posttranslational modification] 512565020590 intermolecular recognition site; other site 512565020591 dimerization interface [polypeptide binding]; other site 512565020592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565020593 DNA binding site [nucleotide binding] 512565020594 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 512565020595 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 512565020596 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 512565020597 FAD binding domain; Region: FAD_binding_4; pfam01565 512565020598 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 512565020599 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 512565020600 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 512565020601 beta-galactosidase; Region: BGL; TIGR03356 512565020602 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512565020603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512565020604 DNA binding site [nucleotide binding] 512565020605 domain linker motif; other site 512565020606 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 512565020607 putative dimerization interface [polypeptide binding]; other site 512565020608 putative ligand binding site [chemical binding]; other site 512565020609 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 512565020610 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565020611 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 512565020612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565020613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565020614 non-specific DNA binding site [nucleotide binding]; other site 512565020615 salt bridge; other site 512565020616 sequence-specific DNA binding site [nucleotide binding]; other site 512565020617 L-asparaginase II; Region: Asparaginase_II; pfam06089 512565020618 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 512565020619 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 512565020620 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 512565020621 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 512565020622 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 512565020623 metal binding site 2 [ion binding]; metal-binding site 512565020624 putative DNA binding helix; other site 512565020625 metal binding site 1 [ion binding]; metal-binding site 512565020626 dimer interface [polypeptide binding]; other site 512565020627 structural Zn2+ binding site [ion binding]; other site 512565020628 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 512565020629 homodimer interface [polypeptide binding]; other site 512565020630 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 512565020631 substrate-cofactor binding pocket; other site 512565020632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565020633 catalytic residue [active] 512565020634 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 512565020635 heme-binding site [chemical binding]; other site 512565020636 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 512565020637 NUDIX domain; Region: NUDIX; pfam00293 512565020638 nudix motif; other site 512565020639 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 512565020640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 512565020641 DEAD_2; Region: DEAD_2; pfam06733 512565020642 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 512565020643 Protein of unknown function (DUF402); Region: DUF402; cl00979 512565020644 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 512565020645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565020646 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565020647 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 512565020648 catalytic site [active] 512565020649 active site 512565020650 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 512565020651 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 512565020652 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565020653 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565020654 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512565020655 NUDIX domain; Region: NUDIX; pfam00293 512565020656 nudix motif; other site 512565020657 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 512565020658 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 512565020659 Walker A/P-loop; other site 512565020660 ATP binding site [chemical binding]; other site 512565020661 Q-loop/lid; other site 512565020662 ABC transporter signature motif; other site 512565020663 Walker B; other site 512565020664 D-loop; other site 512565020665 H-loop/switch region; other site 512565020666 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 512565020667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565020668 dimer interface [polypeptide binding]; other site 512565020669 conserved gate region; other site 512565020670 ABC-ATPase subunit interface; other site 512565020671 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 512565020672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565020673 dimer interface [polypeptide binding]; other site 512565020674 conserved gate region; other site 512565020675 putative PBP binding loops; other site 512565020676 ABC-ATPase subunit interface; other site 512565020677 PBP superfamily domain; Region: PBP_like_2; cl17296 512565020678 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 512565020679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512565020680 Coenzyme A binding pocket [chemical binding]; other site 512565020681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565020682 Coenzyme A binding pocket [chemical binding]; other site 512565020683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565020684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565020685 DNA binding site [nucleotide binding] 512565020686 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 512565020687 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 512565020688 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 512565020689 active site residue [active] 512565020690 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 512565020691 active site residue [active] 512565020692 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 512565020693 Domain of unknown function DUF20; Region: UPF0118; pfam01594 512565020694 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512565020695 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 512565020696 oligomerisation interface [polypeptide binding]; other site 512565020697 mobile loop; other site 512565020698 roof hairpin; other site 512565020699 Protease prsW family; Region: PrsW-protease; pfam13367 512565020700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 512565020701 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 512565020702 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 512565020703 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 512565020704 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 512565020705 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 512565020706 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 512565020707 ring oligomerisation interface [polypeptide binding]; other site 512565020708 ATP/Mg binding site [chemical binding]; other site 512565020709 stacking interactions; other site 512565020710 hinge regions; other site 512565020711 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512565020712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565020713 Coenzyme A binding pocket [chemical binding]; other site 512565020714 threonine synthase; Validated; Region: PRK07591 512565020715 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 512565020716 homodimer interface [polypeptide binding]; other site 512565020717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565020718 catalytic residue [active] 512565020719 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 512565020720 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 512565020721 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 512565020722 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565020723 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565020724 Walker A/P-loop; other site 512565020725 ATP binding site [chemical binding]; other site 512565020726 Q-loop/lid; other site 512565020727 ABC transporter signature motif; other site 512565020728 Walker B; other site 512565020729 D-loop; other site 512565020730 H-loop/switch region; other site 512565020731 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 512565020732 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 512565020733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565020734 Walker A motif; other site 512565020735 ATP binding site [chemical binding]; other site 512565020736 Walker B motif; other site 512565020737 arginine finger; other site 512565020738 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 512565020739 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565020740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565020741 Walker A/P-loop; other site 512565020742 ATP binding site [chemical binding]; other site 512565020743 Q-loop/lid; other site 512565020744 ABC transporter signature motif; other site 512565020745 Walker B; other site 512565020746 D-loop; other site 512565020747 H-loop/switch region; other site 512565020748 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512565020749 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 512565020750 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512565020751 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 512565020752 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 512565020753 dimer interface [polypeptide binding]; other site 512565020754 active site 512565020755 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 512565020756 dimer interface [polypeptide binding]; other site 512565020757 active site 512565020758 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565020759 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512565020760 nucleotide binding site [chemical binding]; other site 512565020761 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 512565020762 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565020763 active site 512565020764 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 512565020765 active site 512565020766 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565020767 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 512565020768 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 512565020769 TrkA-N domain; Region: TrkA_N; pfam02254 512565020770 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 512565020771 TrkA-N domain; Region: TrkA_N; pfam02254 512565020772 PQQ-like domain; Region: PQQ_2; pfam13360 512565020773 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565020774 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 512565020775 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 512565020776 Walker A/P-loop; other site 512565020777 ATP binding site [chemical binding]; other site 512565020778 Q-loop/lid; other site 512565020779 ABC transporter signature motif; other site 512565020780 Walker B; other site 512565020781 D-loop; other site 512565020782 H-loop/switch region; other site 512565020783 TOBE domain; Region: TOBE_2; pfam08402 512565020784 Acyltransferase family; Region: Acyl_transf_3; pfam01757 512565020785 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 512565020786 DNA-binding site [nucleotide binding]; DNA binding site 512565020787 RNA-binding motif; other site 512565020788 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 512565020789 Trp docking motif [polypeptide binding]; other site 512565020790 active site 512565020791 PQQ-like domain; Region: PQQ_2; pfam13360 512565020792 PQQ-like domain; Region: PQQ_2; pfam13360 512565020793 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 512565020794 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 512565020795 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512565020796 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 512565020797 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512565020798 active site 512565020799 HIGH motif; other site 512565020800 nucleotide binding site [chemical binding]; other site 512565020801 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 512565020802 KMSKS motif; other site 512565020803 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 512565020804 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565020805 active site 512565020806 catalytic residues [active] 512565020807 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565020808 catalytic residues [active] 512565020809 fumarate hydratase; Reviewed; Region: fumC; PRK00485 512565020810 Class II fumarases; Region: Fumarase_classII; cd01362 512565020811 active site 512565020812 tetramer interface [polypeptide binding]; other site 512565020813 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 512565020814 DNA binding site [nucleotide binding] 512565020815 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 512565020816 AAA ATPase domain; Region: AAA_16; pfam13191 512565020817 AAA domain; Region: AAA_22; pfam13401 512565020818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565020819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512565020820 binding surface 512565020821 TPR motif; other site 512565020822 Tetratricopeptide repeat; Region: TPR_12; pfam13424 512565020823 fumarate hydratase; Provisional; Region: PRK15389 512565020824 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 512565020825 Fumarase C-terminus; Region: Fumerase_C; pfam05683 512565020826 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 512565020827 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 512565020828 AsnC family; Region: AsnC_trans_reg; pfam01037 512565020829 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 512565020830 RDD family; Region: RDD; pfam06271 512565020831 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 512565020832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565020833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565020834 homodimer interface [polypeptide binding]; other site 512565020835 catalytic residue [active] 512565020836 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512565020837 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512565020838 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 512565020839 PQQ-like domain; Region: PQQ_2; pfam13360 512565020840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 512565020841 TPR motif; other site 512565020842 binding surface 512565020843 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 512565020844 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 512565020845 homotrimer interaction site [polypeptide binding]; other site 512565020846 zinc binding site [ion binding]; other site 512565020847 CDP-binding sites; other site 512565020848 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 512565020849 substrate binding site; other site 512565020850 dimer interface; other site 512565020851 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 512565020852 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 512565020853 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 512565020854 malonyl-CoA binding site [chemical binding]; other site 512565020855 dimer interface [polypeptide binding]; other site 512565020856 active site 512565020857 product binding site; other site 512565020858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 512565020859 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 512565020860 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 512565020861 active site 512565020862 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 512565020863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565020864 DNA repair protein RadA; Provisional; Region: PRK11823 512565020865 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512565020866 Walker A motif; other site 512565020867 ATP binding site [chemical binding]; other site 512565020868 Walker B motif; other site 512565020869 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 512565020870 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 512565020871 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 512565020872 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 512565020873 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 512565020874 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 512565020875 active site 512565020876 catalytic residues [active] 512565020877 metal binding site [ion binding]; metal-binding site 512565020878 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 512565020879 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 512565020880 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 512565020881 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 512565020882 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 512565020883 minor groove reading motif; other site 512565020884 helix-hairpin-helix signature motif; other site 512565020885 substrate binding pocket [chemical binding]; other site 512565020886 active site 512565020887 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 512565020888 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 512565020889 Clp protease ATP binding subunit; Region: clpC; CHL00095 512565020890 Clp amino terminal domain; Region: Clp_N; pfam02861 512565020891 Clp amino terminal domain; Region: Clp_N; pfam02861 512565020892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565020893 Walker A motif; other site 512565020894 ATP binding site [chemical binding]; other site 512565020895 Walker B motif; other site 512565020896 arginine finger; other site 512565020897 UvrB/uvrC motif; Region: UVR; pfam02151 512565020898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565020899 Walker A motif; other site 512565020900 ATP binding site [chemical binding]; other site 512565020901 Walker B motif; other site 512565020902 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 512565020903 Lsr2; Region: Lsr2; pfam11774 512565020904 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 512565020905 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 512565020906 dimer interface [polypeptide binding]; other site 512565020907 putative anticodon binding site; other site 512565020908 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512565020909 motif 1; other site 512565020910 dimer interface [polypeptide binding]; other site 512565020911 active site 512565020912 motif 2; other site 512565020913 motif 3; other site 512565020914 pantothenate kinase; Reviewed; Region: PRK13318 512565020915 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 512565020916 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 512565020917 dimerization interface [polypeptide binding]; other site 512565020918 active site 512565020919 L-aspartate oxidase; Provisional; Region: PRK07804 512565020920 L-aspartate oxidase; Provisional; Region: PRK06175 512565020921 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 512565020922 Septum formation; Region: Septum_form; pfam13845 512565020923 Septum formation; Region: Septum_form; pfam13845 512565020924 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 512565020925 tetramerization interface [polypeptide binding]; other site 512565020926 active site 512565020927 Pantoate-beta-alanine ligase; Region: PanC; cd00560 512565020928 pantoate--beta-alanine ligase; Region: panC; TIGR00018 512565020929 active site 512565020930 ATP-binding site [chemical binding]; other site 512565020931 pantoate-binding site; other site 512565020932 HXXH motif; other site 512565020933 Rossmann-like domain; Region: Rossmann-like; pfam10727 512565020934 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 512565020935 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 512565020936 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 512565020937 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 512565020938 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 512565020939 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 512565020940 catalytic center binding site [active] 512565020941 ATP binding site [chemical binding]; other site 512565020942 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 512565020943 homooctamer interface [polypeptide binding]; other site 512565020944 active site 512565020945 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 512565020946 dihydropteroate synthase; Region: DHPS; TIGR01496 512565020947 substrate binding pocket [chemical binding]; other site 512565020948 dimer interface [polypeptide binding]; other site 512565020949 inhibitor binding site; inhibition site 512565020950 AAA-like domain; Region: AAA_10; pfam12846 512565020951 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565020952 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 512565020953 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 512565020954 NAD binding site [chemical binding]; other site 512565020955 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 512565020956 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565020957 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 512565020958 homodecamer interface [polypeptide binding]; other site 512565020959 GTP cyclohydrolase I; Provisional; Region: PLN03044 512565020960 active site 512565020961 putative catalytic site residues [active] 512565020962 zinc binding site [ion binding]; other site 512565020963 GTP-CH-I/GFRP interaction surface; other site 512565020964 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 512565020965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565020966 Walker A motif; other site 512565020967 ATP binding site [chemical binding]; other site 512565020968 Walker B motif; other site 512565020969 arginine finger; other site 512565020970 Peptidase family M41; Region: Peptidase_M41; pfam01434 512565020971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565020972 active site 512565020973 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 512565020974 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 512565020975 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 512565020976 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 512565020977 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 512565020978 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 512565020979 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 512565020980 dimer interface [polypeptide binding]; other site 512565020981 substrate binding site [chemical binding]; other site 512565020982 metal binding sites [ion binding]; metal-binding site 512565020983 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 512565020984 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 512565020985 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565020986 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 512565020987 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565020988 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512565020989 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512565020990 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 512565020991 active site 512565020992 catalytic residues [active] 512565020993 Colicin V production protein; Region: Colicin_V; pfam02674 512565020994 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 512565020995 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512565020996 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 512565020997 putative active site [active] 512565020998 putative CoA binding site [chemical binding]; other site 512565020999 nudix motif; other site 512565021000 metal binding site [ion binding]; metal-binding site 512565021001 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 512565021002 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512565021003 catalytic residues [active] 512565021004 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 512565021005 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 512565021006 minor groove reading motif; other site 512565021007 helix-hairpin-helix signature motif; other site 512565021008 substrate binding pocket [chemical binding]; other site 512565021009 active site 512565021010 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 512565021011 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 512565021012 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 512565021013 putative active site [active] 512565021014 putative metal binding site [ion binding]; other site 512565021015 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 512565021016 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 512565021017 ligand binding site [chemical binding]; other site 512565021018 flexible hinge region; other site 512565021019 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 512565021020 non-specific DNA interactions [nucleotide binding]; other site 512565021021 DNA binding site [nucleotide binding] 512565021022 sequence specific DNA binding site [nucleotide binding]; other site 512565021023 putative cAMP binding site [chemical binding]; other site 512565021024 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 512565021025 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 512565021026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512565021027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565021028 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 512565021029 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 512565021030 carboxyltransferase (CT) interaction site; other site 512565021031 biotinylation site [posttranslational modification]; other site 512565021032 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512565021033 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512565021034 active site 512565021035 ATP binding site [chemical binding]; other site 512565021036 substrate binding site [chemical binding]; other site 512565021037 activation loop (A-loop); other site 512565021038 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 512565021039 Double zinc ribbon; Region: DZR; pfam12773 512565021040 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 512565021041 cyclase homology domain; Region: CHD; cd07302 512565021042 nucleotidyl binding site; other site 512565021043 metal binding site [ion binding]; metal-binding site 512565021044 dimer interface [polypeptide binding]; other site 512565021045 AAA ATPase domain; Region: AAA_16; pfam13191 512565021046 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 512565021047 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 512565021048 homotrimer interaction site [polypeptide binding]; other site 512565021049 putative active site [active] 512565021050 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 512565021051 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 512565021052 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 512565021053 DTAP/Switch II; other site 512565021054 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 512565021055 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 512565021056 DTAP/Switch II; other site 512565021057 Switch I; other site 512565021058 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565021059 Transcription factor WhiB; Region: Whib; pfam02467 512565021060 Transglycosylase; Region: Transgly; pfam00912 512565021061 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 512565021062 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512565021063 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512565021064 Yqey-like protein; Region: YqeY; cl17540 512565021065 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 512565021066 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512565021067 putative active site [active] 512565021068 putative metal binding site [ion binding]; other site 512565021069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512565021070 active site 512565021071 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 512565021072 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 512565021073 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 512565021074 aspartate kinase; Reviewed; Region: PRK06635 512565021075 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 512565021076 putative nucleotide binding site [chemical binding]; other site 512565021077 putative catalytic residues [active] 512565021078 putative Mg ion binding site [ion binding]; other site 512565021079 putative aspartate binding site [chemical binding]; other site 512565021080 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 512565021081 putative allosteric regulatory site; other site 512565021082 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 512565021083 putative allosteric regulatory residue; other site 512565021084 2-isopropylmalate synthase; Validated; Region: PRK03739 512565021085 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 512565021086 active site 512565021087 catalytic residues [active] 512565021088 metal binding site [ion binding]; metal-binding site 512565021089 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 512565021090 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 512565021091 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021092 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021093 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021094 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021095 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021096 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 512565021097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565021098 Walker A/P-loop; other site 512565021099 ATP binding site [chemical binding]; other site 512565021100 Q-loop/lid; other site 512565021101 ABC transporter signature motif; other site 512565021102 Walker B; other site 512565021103 D-loop; other site 512565021104 H-loop/switch region; other site 512565021105 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 512565021106 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512565021107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512565021108 Walker A/P-loop; other site 512565021109 ATP binding site [chemical binding]; other site 512565021110 Q-loop/lid; other site 512565021111 ABC transporter signature motif; other site 512565021112 Walker B; other site 512565021113 D-loop; other site 512565021114 H-loop/switch region; other site 512565021115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512565021116 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512565021117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565021118 dimer interface [polypeptide binding]; other site 512565021119 conserved gate region; other site 512565021120 putative PBP binding loops; other site 512565021121 ABC-ATPase subunit interface; other site 512565021122 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 512565021123 peptide binding site [polypeptide binding]; other site 512565021124 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 512565021125 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 512565021126 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 512565021127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512565021128 dimer interface [polypeptide binding]; other site 512565021129 conserved gate region; other site 512565021130 putative PBP binding loops; other site 512565021131 ABC-ATPase subunit interface; other site 512565021132 recombination protein RecR; Reviewed; Region: recR; PRK00076 512565021133 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 512565021134 RecR protein; Region: RecR; pfam02132 512565021135 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 512565021136 putative active site [active] 512565021137 putative metal-binding site [ion binding]; other site 512565021138 tetramer interface [polypeptide binding]; other site 512565021139 hypothetical protein; Validated; Region: PRK00153 512565021140 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 512565021141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565021142 Walker A motif; other site 512565021143 ATP binding site [chemical binding]; other site 512565021144 Walker B motif; other site 512565021145 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 512565021146 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 512565021147 anti sigma factor interaction site; other site 512565021148 regulatory phosphorylation site [posttranslational modification]; other site 512565021149 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 512565021150 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 512565021151 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 512565021152 nucleoside/Zn binding site; other site 512565021153 dimer interface [polypeptide binding]; other site 512565021154 catalytic motif [active] 512565021155 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 512565021156 Peptidase family M23; Region: Peptidase_M23; pfam01551 512565021157 Prephenate dehydrogenase; Region: PDH; pfam02153 512565021158 prephenate dehydrogenase; Validated; Region: PRK08507 512565021159 Protein of unknown function (DUF664); Region: DUF664; pfam04978 512565021160 DinB superfamily; Region: DinB_2; pfam12867 512565021161 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 512565021162 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 512565021163 hypothetical protein; Provisional; Region: PRK07945 512565021164 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 512565021165 active site 512565021166 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 512565021167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565021168 HAMP domain; Region: HAMP; pfam00672 512565021169 dimerization interface [polypeptide binding]; other site 512565021170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565021171 ATP binding site [chemical binding]; other site 512565021172 Mg2+ binding site [ion binding]; other site 512565021173 G-X-G motif; other site 512565021174 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 512565021175 Protein of unknown function (DUF742); Region: DUF742; pfam05331 512565021176 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512565021177 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512565021178 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 512565021179 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512565021180 putative catalytic site [active] 512565021181 putative metal binding site [ion binding]; other site 512565021182 putative phosphate binding site [ion binding]; other site 512565021183 active site 512565021184 metal binding site [ion binding]; metal-binding site 512565021185 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 512565021186 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 512565021187 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 512565021188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565021189 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565021190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565021191 MarR family; Region: MarR_2; pfam12802 512565021192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565021193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565021194 putative substrate translocation pore; other site 512565021195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565021196 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565021197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565021198 metal binding site [ion binding]; metal-binding site 512565021199 active site 512565021200 I-site; other site 512565021201 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 512565021202 Domain of unknown function (DUF397); Region: DUF397; pfam04149 512565021203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565021204 non-specific DNA binding site [nucleotide binding]; other site 512565021205 salt bridge; other site 512565021206 sequence-specific DNA binding site [nucleotide binding]; other site 512565021207 Predicted transcriptional regulators [Transcription]; Region: COG1733 512565021208 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565021209 dimerization interface [polypeptide binding]; other site 512565021210 putative DNA binding site [nucleotide binding]; other site 512565021211 putative Zn2+ binding site [ion binding]; other site 512565021212 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 512565021213 putative FMN binding site [chemical binding]; other site 512565021214 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 512565021215 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 512565021216 ATP binding site [chemical binding]; other site 512565021217 active site 512565021218 substrate binding site [chemical binding]; other site 512565021219 HNH endonuclease; Region: HNH_2; pfam13391 512565021220 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565021221 DDE superfamily endonuclease; Region: DDE_5; cl17874 512565021222 H+ Antiporter protein; Region: 2A0121; TIGR00900 512565021223 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 512565021224 active site 512565021225 PQQ-like domain; Region: PQQ_2; pfam13360 512565021226 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 512565021227 Domain of unknown function (DUF305); Region: DUF305; pfam03713 512565021228 Chitin binding domain; Region: Chitin_bind_3; pfam03067 512565021229 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 512565021230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565021231 dimerization interface [polypeptide binding]; other site 512565021232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565021233 ATP binding site [chemical binding]; other site 512565021234 Mg2+ binding site [ion binding]; other site 512565021235 G-X-G motif; other site 512565021236 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565021237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021238 active site 512565021239 phosphorylation site [posttranslational modification] 512565021240 intermolecular recognition site; other site 512565021241 dimerization interface [polypeptide binding]; other site 512565021242 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565021243 DNA binding site [nucleotide binding] 512565021244 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 512565021245 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 512565021246 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 512565021247 active site 512565021248 Zn binding site [ion binding]; other site 512565021249 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 512565021250 BioY family; Region: BioY; pfam02632 512565021251 Predicted RNA-binding proteins [General function prediction only]; Region: PelA; COG1537 512565021252 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512565021253 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512565021254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512565021255 dimerization interface [polypeptide binding]; other site 512565021256 putative DNA binding site [nucleotide binding]; other site 512565021257 putative Zn2+ binding site [ion binding]; other site 512565021258 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021259 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 512565021260 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 512565021261 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 512565021262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512565021263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512565021264 active site 512565021265 catalytic tetrad [active] 512565021266 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 512565021267 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 512565021268 Metal-binding active site; metal-binding site 512565021269 Protein of unknown function (DUF993); Region: DUF993; pfam06187 512565021270 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512565021271 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512565021272 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 512565021273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512565021274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512565021275 catalytic residue [active] 512565021276 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 512565021277 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 512565021278 heme binding pocket [chemical binding]; other site 512565021279 heme ligand [chemical binding]; other site 512565021280 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 512565021281 Htaa; Region: HtaA; pfam04213 512565021282 WxL domain surface cell wall-binding; Region: WxL; pfam13731 512565021283 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 512565021284 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 512565021285 putative hemin binding site; other site 512565021286 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512565021287 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512565021288 ABC-ATPase subunit interface; other site 512565021289 dimer interface [polypeptide binding]; other site 512565021290 putative PBP binding regions; other site 512565021291 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 512565021292 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512565021293 Walker A/P-loop; other site 512565021294 ATP binding site [chemical binding]; other site 512565021295 Q-loop/lid; other site 512565021296 ABC transporter signature motif; other site 512565021297 Walker B; other site 512565021298 D-loop; other site 512565021299 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 512565021300 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 512565021301 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565021302 DNA binding residues [nucleotide binding] 512565021303 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565021304 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 512565021305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512565021306 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 512565021307 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 512565021308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512565021309 Major Facilitator Superfamily; Region: MFS_1; pfam07690 512565021310 putative substrate translocation pore; other site 512565021311 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 512565021312 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 512565021313 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 512565021314 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565021315 hydrophobic ligand binding site; other site 512565021316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565021317 NACHT domain; Region: NACHT; pfam05729 512565021318 Walker A motif; other site 512565021319 ATP binding site [chemical binding]; other site 512565021320 Walker B motif; other site 512565021321 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 512565021322 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 512565021323 DNA binding site [nucleotide binding] 512565021324 AAA ATPase domain; Region: AAA_16; pfam13191 512565021325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565021326 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565021327 DNA binding residues [nucleotide binding] 512565021328 dimerization interface [polypeptide binding]; other site 512565021329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565021330 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512565021331 Walker A motif; other site 512565021332 ATP binding site [chemical binding]; other site 512565021333 Walker B motif; other site 512565021334 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 512565021335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 512565021336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565021337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565021338 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 512565021339 classical (c) SDRs; Region: SDR_c; cd05233 512565021340 NAD(P) binding site [chemical binding]; other site 512565021341 active site 512565021342 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 512565021343 hydrophobic ligand binding site; other site 512565021344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512565021345 AAA domain; Region: AAA_22; pfam13401 512565021346 Walker A motif; other site 512565021347 ATP binding site [chemical binding]; other site 512565021348 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565021349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021350 active site 512565021351 phosphorylation site [posttranslational modification] 512565021352 intermolecular recognition site; other site 512565021353 dimerization interface [polypeptide binding]; other site 512565021354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565021355 DNA binding site [nucleotide binding] 512565021356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565021357 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 512565021358 dimerization interface [polypeptide binding]; other site 512565021359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565021360 dimer interface [polypeptide binding]; other site 512565021361 phosphorylation site [posttranslational modification] 512565021362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565021363 ATP binding site [chemical binding]; other site 512565021364 Mg2+ binding site [ion binding]; other site 512565021365 G-X-G motif; other site 512565021366 HlyD family secretion protein; Region: HlyD_2; pfam12700 512565021367 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512565021368 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512565021369 Walker A/P-loop; other site 512565021370 ATP binding site [chemical binding]; other site 512565021371 Q-loop/lid; other site 512565021372 ABC transporter signature motif; other site 512565021373 Walker B; other site 512565021374 D-loop; other site 512565021375 H-loop/switch region; other site 512565021376 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512565021377 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512565021378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565021379 Walker A/P-loop; other site 512565021380 ATP binding site [chemical binding]; other site 512565021381 Q-loop/lid; other site 512565021382 ABC transporter signature motif; other site 512565021383 Walker B; other site 512565021384 D-loop; other site 512565021385 H-loop/switch region; other site 512565021386 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 512565021387 Histidine kinase; Region: HisKA_3; pfam07730 512565021388 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565021389 ATP binding site [chemical binding]; other site 512565021390 Mg2+ binding site [ion binding]; other site 512565021391 G-X-G motif; other site 512565021392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565021393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021394 active site 512565021395 phosphorylation site [posttranslational modification] 512565021396 intermolecular recognition site; other site 512565021397 dimerization interface [polypeptide binding]; other site 512565021398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565021399 DNA binding residues [nucleotide binding] 512565021400 dimerization interface [polypeptide binding]; other site 512565021401 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565021402 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565021403 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512565021404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512565021405 Walker A/P-loop; other site 512565021406 ATP binding site [chemical binding]; other site 512565021407 Q-loop/lid; other site 512565021408 ABC transporter signature motif; other site 512565021409 Walker B; other site 512565021410 D-loop; other site 512565021411 H-loop/switch region; other site 512565021412 Histidine kinase; Region: HisKA_3; pfam07730 512565021413 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565021414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565021415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021416 active site 512565021417 phosphorylation site [posttranslational modification] 512565021418 intermolecular recognition site; other site 512565021419 dimerization interface [polypeptide binding]; other site 512565021420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565021421 dimerization interface [polypeptide binding]; other site 512565021422 DNA binding residues [nucleotide binding] 512565021423 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 512565021424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512565021425 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 512565021426 homotrimer interaction site [polypeptide binding]; other site 512565021427 putative active site [active] 512565021428 NB-ARC domain; Region: NB-ARC; pfam00931 512565021429 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565021430 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565021431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565021432 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565021433 salt bridge; other site 512565021434 non-specific DNA binding site [nucleotide binding]; other site 512565021435 sequence-specific DNA binding site [nucleotide binding]; other site 512565021436 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 512565021437 active site 512565021438 catalytic triad [active] 512565021439 oxyanion hole [active] 512565021440 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 512565021441 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512565021442 DNA binding residues [nucleotide binding] 512565021443 drug binding residues [chemical binding]; other site 512565021444 dimer interface [polypeptide binding]; other site 512565021445 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565021446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021447 active site 512565021448 phosphorylation site [posttranslational modification] 512565021449 intermolecular recognition site; other site 512565021450 dimerization interface [polypeptide binding]; other site 512565021451 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565021452 DNA binding residues [nucleotide binding] 512565021453 dimerization interface [polypeptide binding]; other site 512565021454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565021455 Histidine kinase; Region: HisKA_3; pfam07730 512565021456 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565021457 CAAX protease self-immunity; Region: Abi; pfam02517 512565021458 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 512565021459 Methyltransferase domain; Region: Methyltransf_24; pfam13578 512565021460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512565021461 Histidine kinase; Region: HisKA_3; pfam07730 512565021462 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512565021463 Mg2+ binding site [ion binding]; other site 512565021464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512565021465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021466 active site 512565021467 phosphorylation site [posttranslational modification] 512565021468 intermolecular recognition site; other site 512565021469 dimerization interface [polypeptide binding]; other site 512565021470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512565021471 DNA binding residues [nucleotide binding] 512565021472 dimerization interface [polypeptide binding]; other site 512565021473 tetracycline repressor protein TetR; Provisional; Region: PRK13756 512565021474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565021475 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 512565021476 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 512565021477 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565021478 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512565021479 active site 512565021480 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 512565021481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512565021482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565021483 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 512565021484 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 512565021485 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 512565021486 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 512565021487 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 512565021488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512565021489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 512565021490 dimerization interface [polypeptide binding]; other site 512565021491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565021492 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 512565021493 NAD(P) binding site [chemical binding]; other site 512565021494 active site 512565021495 CAAX protease self-immunity; Region: Abi; pfam02517 512565021496 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 512565021497 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512565021498 NAD(P) binding site [chemical binding]; other site 512565021499 active site 512565021500 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 512565021501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512565021502 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 512565021503 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 512565021504 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512565021505 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512565021506 Beta-lactamase; Region: Beta-lactamase; pfam00144 512565021507 CAAX protease self-immunity; Region: Abi; pfam02517 512565021508 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 512565021509 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 512565021510 heme-binding site [chemical binding]; other site 512565021511 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 512565021512 FAD binding pocket [chemical binding]; other site 512565021513 FAD binding motif [chemical binding]; other site 512565021514 phosphate binding motif [ion binding]; other site 512565021515 beta-alpha-beta structure motif; other site 512565021516 NAD binding pocket [chemical binding]; other site 512565021517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512565021518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512565021519 non-specific DNA binding site [nucleotide binding]; other site 512565021520 salt bridge; other site 512565021521 sequence-specific DNA binding site [nucleotide binding]; other site 512565021522 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 512565021523 active site 512565021524 catalytic residues [active] 512565021525 metal binding site [ion binding]; metal-binding site 512565021526 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 512565021527 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 512565021528 Methyltransferase domain; Region: Methyltransf_23; pfam13489 512565021529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512565021530 S-adenosylmethionine binding site [chemical binding]; other site 512565021531 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 512565021532 substrate binding site [chemical binding]; other site 512565021533 NlpC/P60 family; Region: NLPC_P60; pfam00877 512565021534 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 512565021535 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 512565021536 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 512565021537 NAD(P) binding site [chemical binding]; other site 512565021538 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 512565021539 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 512565021540 DNA binding residues [nucleotide binding] 512565021541 dimer interface [polypeptide binding]; other site 512565021542 [2Fe-2S] cluster binding site [ion binding]; other site 512565021543 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 512565021544 TPP-binding site [chemical binding]; other site 512565021545 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512565021546 PYR/PP interface [polypeptide binding]; other site 512565021547 dimer interface [polypeptide binding]; other site 512565021548 TPP binding site [chemical binding]; other site 512565021549 Rhomboid family; Region: Rhomboid; pfam01694 512565021550 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 512565021551 active site 512565021552 Protein of unknown function (DUF690); Region: DUF690; cl04939 512565021553 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 512565021554 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 512565021555 oligomer interface [polypeptide binding]; other site 512565021556 metal binding site [ion binding]; metal-binding site 512565021557 metal binding site [ion binding]; metal-binding site 512565021558 putative Cl binding site [ion binding]; other site 512565021559 basic sphincter; other site 512565021560 hydrophobic gate; other site 512565021561 periplasmic entrance; other site 512565021562 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565021563 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 512565021564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565021565 homodimer interface [polypeptide binding]; other site 512565021566 catalytic residue [active] 512565021567 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 512565021568 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 512565021569 active site 512565021570 metal-binding site 512565021571 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 512565021572 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 512565021573 active site 512565021574 NAD binding site [chemical binding]; other site 512565021575 metal binding site [ion binding]; metal-binding site 512565021576 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 512565021577 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 512565021578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512565021579 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512565021580 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 512565021581 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 512565021582 putative DNA binding site [nucleotide binding]; other site 512565021583 catalytic residue [active] 512565021584 putative H2TH interface [polypeptide binding]; other site 512565021585 putative catalytic residues [active] 512565021586 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 512565021587 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512565021588 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 512565021589 Bacterial sugar transferase; Region: Bac_transf; pfam02397 512565021590 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 512565021591 Histidine kinase; Region: His_kinase; pfam06580 512565021592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565021593 ATP binding site [chemical binding]; other site 512565021594 Mg2+ binding site [ion binding]; other site 512565021595 G-X-G motif; other site 512565021596 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 512565021597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021598 active site 512565021599 phosphorylation site [posttranslational modification] 512565021600 intermolecular recognition site; other site 512565021601 dimerization interface [polypeptide binding]; other site 512565021602 LytTr DNA-binding domain; Region: LytTR; smart00850 512565021603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512565021604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512565021605 active site 512565021606 phosphorylation site [posttranslational modification] 512565021607 intermolecular recognition site; other site 512565021608 dimerization interface [polypeptide binding]; other site 512565021609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512565021610 DNA binding site [nucleotide binding] 512565021611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512565021612 dimerization interface [polypeptide binding]; other site 512565021613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565021614 dimer interface [polypeptide binding]; other site 512565021615 phosphorylation site [posttranslational modification] 512565021616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565021617 ATP binding site [chemical binding]; other site 512565021618 Mg2+ binding site [ion binding]; other site 512565021619 G-X-G motif; other site 512565021620 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 512565021621 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 512565021622 Na binding site [ion binding]; other site 512565021623 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512565021624 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 512565021625 Walker A/P-loop; other site 512565021626 ATP binding site [chemical binding]; other site 512565021627 Q-loop/lid; other site 512565021628 ABC transporter signature motif; other site 512565021629 Walker B; other site 512565021630 D-loop; other site 512565021631 H-loop/switch region; other site 512565021632 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 512565021633 Protein of unknown function, DUF485; Region: DUF485; pfam04341 512565021634 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 512565021635 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 512565021636 Na binding site [ion binding]; other site 512565021637 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 512565021638 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 512565021639 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 512565021640 active site residue [active] 512565021641 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 512565021642 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 512565021643 active site 512565021644 catalytic site [active] 512565021645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512565021646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512565021647 dimer interface [polypeptide binding]; other site 512565021648 phosphorylation site [posttranslational modification] 512565021649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512565021650 ATP binding site [chemical binding]; other site 512565021651 Mg2+ binding site [ion binding]; other site 512565021652 G-X-G motif; other site 512565021653 arginine deiminase; Provisional; Region: PRK01388 512565021654 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 512565021655 Uncharacterized conserved protein [Function unknown]; Region: COG3603 512565021656 Family description; Region: ACT_7; pfam13840 512565021657 prephenate dehydratase; Provisional; Region: PRK11898 512565021658 Prephenate dehydratase; Region: PDT; pfam00800 512565021659 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 512565021660 putative L-Phe binding site [chemical binding]; other site 512565021661 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 512565021662 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 512565021663 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 512565021664 seryl-tRNA synthetase; Provisional; Region: PRK05431 512565021665 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 512565021666 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 512565021667 dimer interface [polypeptide binding]; other site 512565021668 active site 512565021669 motif 1; other site 512565021670 motif 2; other site 512565021671 motif 3; other site 512565021672 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512565021673 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565021674 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565021675 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512565021676 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512565021677 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 512565021678 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 512565021679 Amidinotransferase; Region: Amidinotransf; cl12043 512565021680 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 512565021681 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 512565021682 putative DNA binding site [nucleotide binding]; other site 512565021683 putative Zn2+ binding site [ion binding]; other site 512565021684 AsnC family; Region: AsnC_trans_reg; pfam01037 512565021685 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 512565021686 active site 512565021687 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 512565021688 potential frameshift: common BLAST hit: gi|302869150|ref|YP_003837787.1| alkaline phosphatase 512565021689 PhoD-like phosphatase; Region: PhoD; pfam09423 512565021690 PhoD-like phosphatase; Region: PhoD; pfam09423 512565021691 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 512565021692 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 512565021693 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 512565021694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512565021695 Coenzyme A binding pocket [chemical binding]; other site 512565021696 Phosphotransferase enzyme family; Region: APH; pfam01636 512565021697 Fructosamine kinase; Region: Fructosamin_kin; cl17579 512565021698 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 512565021699 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512565021700 FeS/SAM binding site; other site 512565021701 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 512565021702 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 512565021703 phosphodiesterase YaeI; Provisional; Region: PRK11340 512565021704 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 512565021705 putative active site [active] 512565021706 putative metal binding site [ion binding]; other site 512565021707 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 512565021708 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 512565021709 Part of AAA domain; Region: AAA_19; pfam13245 512565021710 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512565021711 Family description; Region: UvrD_C_2; pfam13538 512565021712 AAA ATPase domain; Region: AAA_16; pfam13191 512565021713 Predicted membrane protein [Function unknown]; Region: COG2259 512565021714 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 512565021715 MoaE homodimer interface [polypeptide binding]; other site 512565021716 MoaD interaction [polypeptide binding]; other site 512565021717 active site residues [active] 512565021718 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 512565021719 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 512565021720 dimer interface [polypeptide binding]; other site 512565021721 putative functional site; other site 512565021722 putative MPT binding site; other site 512565021723 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 512565021724 MPT binding site; other site 512565021725 trimer interface [polypeptide binding]; other site 512565021726 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 512565021727 trimer interface [polypeptide binding]; other site 512565021728 dimer interface [polypeptide binding]; other site 512565021729 putative active site [active] 512565021730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 512565021731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 512565021732 metal binding site [ion binding]; metal-binding site 512565021733 active site 512565021734 I-site; other site 512565021735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 512565021736 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 512565021737 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 512565021738 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 512565021739 replicative DNA helicase; Region: DnaB; TIGR00665 512565021740 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 512565021741 Walker A motif; other site 512565021742 ATP binding site [chemical binding]; other site 512565021743 Walker B motif; other site 512565021744 DNA binding loops [nucleotide binding] 512565021745 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 512565021746 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 512565021747 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 512565021748 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 512565021749 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 512565021750 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 512565021751 dimer interface [polypeptide binding]; other site 512565021752 ssDNA binding site [nucleotide binding]; other site 512565021753 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512565021754 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 512565021755 endonuclease IV; Provisional; Region: PRK01060 512565021756 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 512565021757 AP (apurinic/apyrimidinic) site pocket; other site 512565021758 DNA interaction; other site 512565021759 Metal-binding active site; metal-binding site 512565021760 Predicted integral membrane protein [Function unknown]; Region: COG5650 512565021761 Transglycosylase; Region: Transgly; pfam00912 512565021762 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 512565021763 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512565021764 Predicted transcriptional regulators [Transcription]; Region: COG1695 512565021765 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512565021766 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 512565021767 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 512565021768 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 512565021769 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 512565021770 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 512565021771 DNA binding site [nucleotide binding] 512565021772 active site 512565021773 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565021774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565021775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565021776 DNA binding residues [nucleotide binding] 512565021777 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 512565021778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565021779 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512565021780 DNA binding residues [nucleotide binding] 512565021781 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 512565021782 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 512565021783 active site 512565021784 NTP binding site [chemical binding]; other site 512565021785 metal binding triad [ion binding]; metal-binding site 512565021786 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 512565021787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512565021788 Zn2+ binding site [ion binding]; other site 512565021789 Mg2+ binding site [ion binding]; other site 512565021790 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 512565021791 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 512565021792 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512565021793 active site 512565021794 ATP binding site [chemical binding]; other site 512565021795 substrate binding site [chemical binding]; other site 512565021796 activation loop (A-loop); other site 512565021797 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 512565021798 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512565021799 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 512565021800 DNA binding residues [nucleotide binding] 512565021801 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 512565021802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512565021803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512565021804 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512565021805 catalytic residues [active] 512565021806 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 512565021807 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 512565021808 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 512565021809 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 512565021810 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 512565021811 active site 512565021812 metal binding site [ion binding]; metal-binding site 512565021813 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 512565021814 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 512565021815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512565021816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512565021817 homodimer interface [polypeptide binding]; other site 512565021818 catalytic residue [active] 512565021819 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 512565021820 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 512565021821 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512565021822 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 512565021823 ParB-like nuclease domain; Region: ParBc; pfam02195 512565021824 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 512565021825 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512565021826 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 512565021827 Magnesium ion binding site [ion binding]; other site 512565021828 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 512565021829 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 512565021830 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 512565021831 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 512565021832 G-X-X-G motif; other site 512565021833 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 512565021834 RxxxH motif; other site 512565021835 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 512565021836 Haemolytic domain; Region: Haemolytic; pfam01809 512565021837 Ribonuclease P; Region: Ribonuclease_P; cl00457 512565021838 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399