-- dump date 20140618_192005 -- class Genbank::misc_feature -- table misc_feature_note -- id note 746697000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 746697000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 746697000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697000004 Walker A motif; other site 746697000005 ATP binding site [chemical binding]; other site 746697000006 Walker B motif; other site 746697000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 746697000008 arginine finger; other site 746697000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 746697000010 DnaA box-binding interface [nucleotide binding]; other site 746697000011 methionine sulfoxide reductase B; Provisional; Region: PRK00222 746697000012 SelR domain; Region: SelR; pfam01641 746697000013 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697000014 Family of unknown function (DUF490); Region: DUF490; pfam04357 746697000015 Uncharacterized conserved protein [Function unknown]; Region: COG2353 746697000016 Pirin-related protein [General function prediction only]; Region: COG1741 746697000017 Pirin; Region: Pirin; pfam02678 746697000018 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 746697000019 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 746697000020 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746697000021 ligand binding site [chemical binding]; other site 746697000022 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 746697000023 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 746697000024 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 746697000025 Outer membrane efflux protein; Region: OEP; pfam02321 746697000026 Outer membrane efflux protein; Region: OEP; pfam02321 746697000027 HlyD family secretion protein; Region: HlyD_2; pfam12700 746697000028 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697000029 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 746697000030 putative DNA binding helix; other site 746697000031 metal binding site 2 [ion binding]; metal-binding site 746697000032 metal binding site 1 [ion binding]; metal-binding site 746697000033 dimer interface [polypeptide binding]; other site 746697000034 structural Zn2+ binding site [ion binding]; other site 746697000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 746697000036 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 746697000037 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746697000038 Soluble P-type ATPase [General function prediction only]; Region: COG4087 746697000039 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 746697000040 H+ Antiporter protein; Region: 2A0121; TIGR00900 746697000041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697000042 putative substrate translocation pore; other site 746697000043 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 746697000044 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000045 Ligand Binding Site [chemical binding]; other site 746697000046 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 746697000047 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 746697000048 active site 746697000049 FMN binding site [chemical binding]; other site 746697000050 substrate binding site [chemical binding]; other site 746697000051 3Fe-4S cluster binding site [ion binding]; other site 746697000052 pyruvate dehydrogenase; Provisional; Region: PRK09124 746697000053 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 746697000054 PYR/PP interface [polypeptide binding]; other site 746697000055 dimer interface [polypeptide binding]; other site 746697000056 tetramer interface [polypeptide binding]; other site 746697000057 TPP binding site [chemical binding]; other site 746697000058 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 746697000059 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 746697000060 TPP-binding site [chemical binding]; other site 746697000061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697000062 non-specific DNA binding site [nucleotide binding]; other site 746697000063 salt bridge; other site 746697000064 sequence-specific DNA binding site [nucleotide binding]; other site 746697000065 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 746697000066 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 746697000067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697000068 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 746697000069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697000070 DNA binding residues [nucleotide binding] 746697000071 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 746697000072 TrkA-C domain; Region: TrkA_C; pfam02080 746697000073 TrkA-C domain; Region: TrkA_C; pfam02080 746697000074 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 746697000075 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 746697000076 Conserved TM helix; Region: TM_helix; pfam05552 746697000077 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746697000078 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697000079 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 746697000080 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697000081 ligand binding site [chemical binding]; other site 746697000082 short chain dehydrogenase; Provisional; Region: PRK07326 746697000083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697000084 NAD(P) binding site [chemical binding]; other site 746697000085 active site 746697000086 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 746697000087 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746697000088 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697000089 integral membrane protein; Region: integ_memb_HG; TIGR03954 746697000090 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697000091 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746697000092 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 746697000093 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 746697000094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 746697000095 GMP synthase; Reviewed; Region: guaA; PRK00074 746697000096 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 746697000097 AMP/PPi binding site [chemical binding]; other site 746697000098 candidate oxyanion hole; other site 746697000099 catalytic triad [active] 746697000100 potential glutamine specificity residues [chemical binding]; other site 746697000101 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 746697000102 ATP Binding subdomain [chemical binding]; other site 746697000103 Ligand Binding sites [chemical binding]; other site 746697000104 Dimerization subdomain; other site 746697000105 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697000106 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 746697000107 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697000108 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 746697000109 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697000110 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697000111 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 746697000112 ligand binding site [chemical binding]; other site 746697000113 OsmC-like protein; Region: OsmC; pfam02566 746697000114 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 746697000115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697000116 CTP synthetase; Validated; Region: pyrG; PRK05380 746697000117 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 746697000118 Catalytic site [active] 746697000119 active site 746697000120 UTP binding site [chemical binding]; other site 746697000121 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 746697000122 active site 746697000123 putative oxyanion hole; other site 746697000124 catalytic triad [active] 746697000125 membrane protein insertase; Provisional; Region: PRK01318 746697000126 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 746697000127 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 746697000128 Zn binding site [ion binding]; other site 746697000129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697000130 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 746697000131 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 746697000132 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 746697000133 active site 746697000134 catalytic residues [active] 746697000135 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000136 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 746697000137 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 746697000138 FMN binding site [chemical binding]; other site 746697000139 substrate binding site [chemical binding]; other site 746697000140 putative catalytic residue [active] 746697000141 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 746697000142 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 746697000143 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 746697000144 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 746697000145 Zn binding site [ion binding]; other site 746697000146 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 746697000147 HYR domain; Region: HYR; pfam02494 746697000148 HYR domain; Region: HYR; pfam02494 746697000149 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000150 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746697000151 DNA-binding site [nucleotide binding]; DNA binding site 746697000152 RNA-binding motif; other site 746697000153 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 746697000154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746697000155 diaminopimelate decarboxylase; Region: lysA; TIGR01048 746697000156 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 746697000157 active site 746697000158 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746697000159 substrate binding site [chemical binding]; other site 746697000160 catalytic residues [active] 746697000161 dimer interface [polypeptide binding]; other site 746697000162 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 746697000163 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 746697000164 CoA-ligase; Region: Ligase_CoA; pfam00549 746697000165 Predicted membrane protein [Function unknown]; Region: COG4325 746697000166 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 746697000167 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 746697000168 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 746697000169 putative dimer interface [polypeptide binding]; other site 746697000170 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 746697000171 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746697000172 RNA binding surface [nucleotide binding]; other site 746697000173 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 746697000174 probable active site [active] 746697000175 GH3 auxin-responsive promoter; Region: GH3; pfam03321 746697000176 excinuclease ABC subunit B; Provisional; Region: PRK05298 746697000177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697000178 ATP binding site [chemical binding]; other site 746697000179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697000180 nucleotide binding region [chemical binding]; other site 746697000181 ATP-binding site [chemical binding]; other site 746697000182 Ultra-violet resistance protein B; Region: UvrB; pfam12344 746697000183 UvrB/uvrC motif; Region: UVR; pfam02151 746697000184 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 746697000185 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 746697000186 phosphopeptide binding site; other site 746697000187 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 746697000188 Protein phosphatase 2C; Region: PP2C; pfam00481 746697000189 active site 746697000190 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 746697000191 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 746697000192 active site 746697000193 ATP binding site [chemical binding]; other site 746697000194 substrate binding site [chemical binding]; other site 746697000195 activation loop (A-loop); other site 746697000196 Helix-turn-helix domain; Region: HTH_28; pfam13518 746697000197 IS2 transposase TnpB; Reviewed; Region: PRK09409 746697000198 Homeodomain-like domain; Region: HTH_32; pfam13565 746697000199 Integrase core domain; Region: rve; pfam00665 746697000200 Integrase core domain; Region: rve_3; pfam13683 746697000201 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 746697000202 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 746697000203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697000204 TPR motif; other site 746697000205 binding surface 746697000206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697000207 binding surface 746697000208 TPR motif; other site 746697000209 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 746697000210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697000211 salt bridge; other site 746697000212 non-specific DNA binding site [nucleotide binding]; other site 746697000213 sequence-specific DNA binding site [nucleotide binding]; other site 746697000214 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 746697000215 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 746697000216 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 746697000217 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 746697000218 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 746697000219 Predicted membrane protein [Function unknown]; Region: COG2855 746697000220 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746697000221 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697000222 EamA-like transporter family; Region: EamA; pfam00892 746697000223 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 746697000224 EamA-like transporter family; Region: EamA; pfam00892 746697000225 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 746697000226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697000227 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 746697000228 NAD(P) binding site [chemical binding]; other site 746697000229 active site 746697000230 META domain; Region: META; pfam03724 746697000231 META domain; Region: META; pfam03724 746697000232 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 746697000233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697000234 putative substrate translocation pore; other site 746697000235 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 746697000236 active site 746697000237 homotetramer interface [polypeptide binding]; other site 746697000238 Domain of unknown function (DUF336); Region: DUF336; cl01249 746697000239 TrkA-C domain; Region: TrkA_C; pfam02080 746697000240 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746697000241 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 746697000242 ligand binding site [chemical binding]; other site 746697000243 flexible hinge region; other site 746697000244 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 746697000245 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000246 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 746697000247 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 746697000248 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 746697000249 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 746697000250 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 746697000251 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 746697000252 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697000253 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697000254 catalytic residues [active] 746697000255 starch binding outer membrane protein SusD; Region: SusD; cd08977 746697000256 FecR protein; Region: FecR; pfam04773 746697000257 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 746697000258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697000259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697000260 DNA binding residues [nucleotide binding] 746697000261 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 746697000262 HemN C-terminal domain; Region: HemN_C; pfam06969 746697000263 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 746697000264 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 746697000265 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 746697000266 Multicopper oxidase; Region: Cu-oxidase; pfam00394 746697000267 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 746697000268 Cytochrome c; Region: Cytochrom_C; pfam00034 746697000269 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 746697000270 Uncharacterized conserved protein [Function unknown]; Region: COG1262 746697000271 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 746697000272 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 746697000273 Cu(I) binding site [ion binding]; other site 746697000274 Family description; Region: DsbD_2; pfam13386 746697000275 FixH; Region: FixH; pfam05751 746697000276 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 746697000277 4Fe-4S binding domain; Region: Fer4_5; pfam12801 746697000278 BCCT family transporter; Region: BCCT; cl00569 746697000279 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 746697000280 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 746697000281 Cytochrome c; Region: Cytochrom_C; pfam00034 746697000282 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 746697000283 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 746697000284 Low-spin heme binding site [chemical binding]; other site 746697000285 Putative water exit pathway; other site 746697000286 Binuclear center (active site) [active] 746697000287 Putative proton exit pathway; other site 746697000288 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 746697000289 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 746697000290 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 746697000291 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 746697000292 Heavy-metal-associated domain; Region: HMA; pfam00403 746697000293 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746697000294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697000295 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 746697000296 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 746697000297 Hemerythrin-like domain; Region: Hr-like; cd12108 746697000298 Hemerythrin-like domain; Region: Hr-like; cd12108 746697000299 short chain dehydrogenase; Provisional; Region: PRK07326 746697000300 classical (c) SDRs; Region: SDR_c; cd05233 746697000301 NAD(P) binding site [chemical binding]; other site 746697000302 active site 746697000303 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 746697000304 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 746697000305 FAD binding pocket [chemical binding]; other site 746697000306 conserved FAD binding motif [chemical binding]; other site 746697000307 phosphate binding motif [ion binding]; other site 746697000308 beta-alpha-beta structure motif; other site 746697000309 NAD binding pocket [chemical binding]; other site 746697000310 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 746697000311 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 746697000312 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 746697000313 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 746697000314 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 746697000315 Low-spin heme binding site [chemical binding]; other site 746697000316 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 746697000317 D-pathway; other site 746697000318 Putative water exit pathway; other site 746697000319 Binuclear center (active site) [active] 746697000320 K-pathway; other site 746697000321 Putative proton exit pathway; other site 746697000322 Rrf2 family protein; Region: rrf2_super; TIGR00738 746697000323 Transcriptional regulator; Region: Rrf2; pfam02082 746697000324 Predicted transcriptional regulator [Transcription]; Region: COG1959 746697000325 Transcriptional regulator; Region: Rrf2; pfam02082 746697000326 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 746697000327 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 746697000328 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 746697000329 Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659 746697000330 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 746697000331 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746697000332 Walker A/P-loop; other site 746697000333 ATP binding site [chemical binding]; other site 746697000334 Q-loop/lid; other site 746697000335 ABC transporter signature motif; other site 746697000336 Walker B; other site 746697000337 D-loop; other site 746697000338 H-loop/switch region; other site 746697000339 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 746697000340 NosL; Region: NosL; cl01769 746697000341 nitrous-oxide reductase, Sec-dependent; Region: nitrous_NosZ_Gp; TIGR04246 746697000342 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 746697000343 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 746697000344 Fasciclin domain; Region: Fasciclin; pfam02469 746697000345 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 746697000346 Cytochrome c; Region: Cytochrom_C; pfam00034 746697000347 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000348 Ligand Binding Site [chemical binding]; other site 746697000349 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000350 Ligand Binding Site [chemical binding]; other site 746697000351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000352 Ligand Binding Site [chemical binding]; other site 746697000353 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000354 Ligand Binding Site [chemical binding]; other site 746697000355 Response regulator receiver domain; Region: Response_reg; pfam00072 746697000356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697000357 active site 746697000358 phosphorylation site [posttranslational modification] 746697000359 intermolecular recognition site; other site 746697000360 dimerization interface [polypeptide binding]; other site 746697000361 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746697000362 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 746697000363 ligand binding site [chemical binding]; other site 746697000364 flexible hinge region; other site 746697000365 putative switch regulator; other site 746697000366 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 746697000367 non-specific DNA interactions [nucleotide binding]; other site 746697000368 DNA binding site [nucleotide binding] 746697000369 sequence specific DNA binding site [nucleotide binding]; other site 746697000370 putative cAMP binding site [chemical binding]; other site 746697000371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 746697000372 PAS domain; Region: PAS_9; pfam13426 746697000373 putative active site [active] 746697000374 heme pocket [chemical binding]; other site 746697000375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697000376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697000377 dimer interface [polypeptide binding]; other site 746697000378 phosphorylation site [posttranslational modification] 746697000379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697000380 ATP binding site [chemical binding]; other site 746697000381 Mg2+ binding site [ion binding]; other site 746697000382 G-X-G motif; other site 746697000383 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 746697000384 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746697000385 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697000386 catalytic residues [active] 746697000387 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 746697000388 intersubunit interface [polypeptide binding]; other site 746697000389 active site 746697000390 catalytic residue [active] 746697000391 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 746697000392 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 746697000393 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000394 Ligand Binding Site [chemical binding]; other site 746697000395 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697000396 Ligand Binding Site [chemical binding]; other site 746697000397 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 746697000398 30S subunit binding site; other site 746697000399 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 746697000400 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 746697000401 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 746697000402 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 746697000403 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697000404 Outer membrane efflux protein; Region: OEP; pfam02321 746697000405 Outer membrane efflux protein; Region: OEP; pfam02321 746697000406 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697000408 S-adenosylmethionine binding site [chemical binding]; other site 746697000409 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 746697000410 Domain of unknown function DUF302; Region: DUF302; pfam03625 746697000411 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 746697000412 GIY-YIG motif/motif A; other site 746697000413 putative active site [active] 746697000414 putative metal binding site [ion binding]; other site 746697000415 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 746697000416 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 746697000417 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746697000418 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 746697000419 Fic/DOC family; Region: Fic; cl00960 746697000420 Virulence protein [General function prediction only]; Region: COG3943 746697000421 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 746697000422 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 746697000423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697000424 ATP binding site [chemical binding]; other site 746697000425 putative Mg++ binding site [ion binding]; other site 746697000426 Helix-turn-helix domain; Region: HTH_17; pfam12728 746697000427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697000428 binding surface 746697000429 TPR motif; other site 746697000430 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697000431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697000432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697000433 ATP binding site [chemical binding]; other site 746697000434 Mg2+ binding site [ion binding]; other site 746697000435 G-X-G motif; other site 746697000436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697000437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 746697000438 active site 746697000439 phosphorylation site [posttranslational modification] 746697000440 intermolecular recognition site; other site 746697000441 dimerization interface [polypeptide binding]; other site 746697000442 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 746697000443 Haemolytic domain; Region: Haemolytic; cl00506 746697000444 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 746697000445 Staphylococcal nuclease homologues; Region: SNc; smart00318 746697000446 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 746697000447 Catalytic site; other site 746697000448 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 746697000449 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 746697000450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 746697000451 non-specific DNA binding site [nucleotide binding]; other site 746697000452 salt bridge; other site 746697000453 sequence-specific DNA binding site [nucleotide binding]; other site 746697000454 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 746697000455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697000456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697000457 DNA binding residues [nucleotide binding] 746697000458 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 746697000459 GIY-YIG motif/motif A; other site 746697000460 putative active site [active] 746697000461 putative metal binding site [ion binding]; other site 746697000462 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 746697000463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 746697000464 non-specific DNA binding site [nucleotide binding]; other site 746697000465 salt bridge; other site 746697000466 sequence-specific DNA binding site [nucleotide binding]; other site 746697000467 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 746697000468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697000469 active site 746697000470 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 746697000471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697000472 S-adenosylmethionine binding site [chemical binding]; other site 746697000473 cytochrome c-550; Provisional; Region: psbV; PRK13622 746697000474 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 746697000475 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 746697000476 ligand binding site [chemical binding]; other site 746697000477 flexible hinge region; other site 746697000478 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 746697000479 putative switch regulator; other site 746697000480 non-specific DNA interactions [nucleotide binding]; other site 746697000481 DNA binding site [nucleotide binding] 746697000482 sequence specific DNA binding site [nucleotide binding]; other site 746697000483 putative cAMP binding site [chemical binding]; other site 746697000484 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 746697000485 active site 746697000486 putative catalytic site [active] 746697000487 DNA binding site [nucleotide binding] 746697000488 putative phosphate binding site [ion binding]; other site 746697000489 metal binding site A [ion binding]; metal-binding site 746697000490 AP binding site [nucleotide binding]; other site 746697000491 metal binding site B [ion binding]; metal-binding site 746697000492 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697000493 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 746697000494 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 746697000495 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 746697000496 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 746697000497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746697000498 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 746697000499 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 746697000500 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 746697000501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 746697000502 carboxyltransferase (CT) interaction site; other site 746697000503 biotinylation site [posttranslational modification]; other site 746697000504 CHAT domain; Region: CHAT; pfam12770 746697000505 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 746697000506 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 746697000507 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 746697000508 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 746697000509 Catalytic site [active] 746697000510 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 746697000511 dihydrodipicolinate reductase; Provisional; Region: PRK00048 746697000512 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 746697000513 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 746697000514 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 746697000515 ParB-like nuclease domain; Region: ParBc; pfam02195 746697000516 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 746697000517 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 746697000518 P-loop; other site 746697000519 Magnesium ion binding site [ion binding]; other site 746697000520 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 746697000521 Magnesium ion binding site [ion binding]; other site 746697000522 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 746697000523 short chain dehydrogenase; Provisional; Region: PRK07677 746697000524 NAD(P) binding site [chemical binding]; other site 746697000525 substrate binding site [chemical binding]; other site 746697000526 homotetramer interface [polypeptide binding]; other site 746697000527 active site 746697000528 homodimer interface [polypeptide binding]; other site 746697000529 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 746697000530 NADH(P)-binding; Region: NAD_binding_10; pfam13460 746697000531 NAD(P) binding site [chemical binding]; other site 746697000532 putative active site [active] 746697000533 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 746697000534 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000535 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 746697000536 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 746697000537 NAD(P) binding site [chemical binding]; other site 746697000538 catalytic residues [active] 746697000539 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697000540 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 746697000541 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746697000542 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 746697000543 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 746697000544 ATP binding site [chemical binding]; other site 746697000545 Mg++ binding site [ion binding]; other site 746697000546 motif III; other site 746697000547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697000548 nucleotide binding region [chemical binding]; other site 746697000549 ATP-binding site [chemical binding]; other site 746697000550 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 746697000551 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 746697000552 active site 746697000553 dimerization interface [polypeptide binding]; other site 746697000554 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746697000555 NAD-dependent deacetylase; Provisional; Region: PRK00481 746697000556 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 746697000557 NAD+ binding site [chemical binding]; other site 746697000558 substrate binding site [chemical binding]; other site 746697000559 Zn binding site [ion binding]; other site 746697000560 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 746697000561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697000562 Predicted membrane protein [Function unknown]; Region: COG2323 746697000563 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 746697000564 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 746697000565 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 746697000566 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 746697000567 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 746697000568 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000569 HYR domain; Region: HYR; pfam02494 746697000570 HYR domain; Region: HYR; pfam02494 746697000571 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000572 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 746697000573 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746697000574 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746697000575 active site residue [active] 746697000576 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877 746697000577 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697000578 metal binding site [ion binding]; metal-binding site 746697000579 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 746697000580 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 746697000581 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 746697000582 homodimer interface [polypeptide binding]; other site 746697000583 substrate-cofactor binding pocket; other site 746697000584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697000585 catalytic residue [active] 746697000586 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 746697000587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697000588 Coenzyme A binding pocket [chemical binding]; other site 746697000589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697000590 binding surface 746697000591 TPR repeat; Region: TPR_11; pfam13414 746697000592 TPR motif; other site 746697000593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697000594 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 746697000595 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 746697000596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746697000597 dimerization interface [polypeptide binding]; other site 746697000598 putative DNA binding site [nucleotide binding]; other site 746697000599 putative Zn2+ binding site [ion binding]; other site 746697000600 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 746697000601 SdpI/YhfL protein family; Region: SdpI; pfam13630 746697000602 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 746697000603 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 746697000604 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 746697000605 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697000606 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697000607 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697000608 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 746697000609 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 746697000610 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 746697000611 putative active site [active] 746697000612 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000613 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 746697000614 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 746697000615 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 746697000616 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 746697000617 active site 746697000618 dimer interface [polypeptide binding]; other site 746697000619 motif 1; other site 746697000620 motif 2; other site 746697000621 motif 3; other site 746697000622 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 746697000623 anticodon binding site; other site 746697000624 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 746697000625 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 746697000626 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 746697000627 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 746697000628 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 746697000629 23S rRNA binding site [nucleotide binding]; other site 746697000630 L21 binding site [polypeptide binding]; other site 746697000631 L13 binding site [polypeptide binding]; other site 746697000632 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697000633 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697000634 ligand binding site [chemical binding]; other site 746697000635 replicative DNA helicase; Region: DnaB; TIGR00665 746697000636 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 746697000637 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 746697000638 Walker A motif; other site 746697000639 ATP binding site [chemical binding]; other site 746697000640 Walker B motif; other site 746697000641 DNA binding loops [nucleotide binding] 746697000642 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 746697000643 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 746697000644 EamA-like transporter family; Region: EamA; pfam00892 746697000645 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 746697000646 Predicted permeases [General function prediction only]; Region: COG0795 746697000647 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 746697000648 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 746697000649 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 746697000650 transketolase; Reviewed; Region: PRK05899 746697000651 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 746697000652 TPP-binding site [chemical binding]; other site 746697000653 dimer interface [polypeptide binding]; other site 746697000654 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 746697000655 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 746697000656 PYR/PP interface [polypeptide binding]; other site 746697000657 dimer interface [polypeptide binding]; other site 746697000658 TPP binding site [chemical binding]; other site 746697000659 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746697000660 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 746697000661 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746697000662 RNA binding surface [nucleotide binding]; other site 746697000663 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697000664 active site 746697000665 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 746697000666 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 746697000667 ADP binding site [chemical binding]; other site 746697000668 magnesium binding site [ion binding]; other site 746697000669 putative shikimate binding site; other site 746697000670 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 746697000671 DNA binding residues [nucleotide binding] 746697000672 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 746697000673 B12 binding domain; Region: B12-binding_2; pfam02607 746697000674 phytoene desaturase; Region: crtI_fam; TIGR02734 746697000675 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746697000676 Alpha-helical domain of GINS complex proteins; Sld5, Psf1, Psf2 and Psf3; Region: GINS_A; cl17012 746697000677 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 746697000678 active site lid residues [active] 746697000679 substrate binding pocket [chemical binding]; other site 746697000680 catalytic residues [active] 746697000681 substrate-Mg2+ binding site; other site 746697000682 aspartate-rich region 1; other site 746697000683 aspartate-rich region 2; other site 746697000684 beta-carotene hydroxylase; Region: PLN02601 746697000685 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 746697000686 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697000687 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697000688 catalytic residues [active] 746697000689 aconitate hydratase; Validated; Region: PRK07229 746697000690 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584 746697000691 substrate binding site [chemical binding]; other site 746697000692 ligand binding site [chemical binding]; other site 746697000693 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 746697000694 substrate binding site [chemical binding]; other site 746697000695 MoxR-like ATPases [General function prediction only]; Region: COG0714 746697000696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697000697 Walker A motif; other site 746697000698 ATP binding site [chemical binding]; other site 746697000699 Walker B motif; other site 746697000700 arginine finger; other site 746697000701 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 746697000702 SurA N-terminal domain; Region: SurA_N; pfam09312 746697000703 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 746697000704 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 746697000705 peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925 746697000706 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 746697000707 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 746697000708 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 746697000709 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 746697000710 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 746697000711 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 746697000712 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 746697000713 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 746697000714 active site 746697000715 Haem-binding domain; Region: Haem_bd; pfam14376 746697000716 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 746697000717 Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406 746697000718 putative active site [active] 746697000719 putative metal binding site [ion binding]; other site 746697000720 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 746697000721 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 746697000722 active site 746697000723 catalytic residues [active] 746697000724 metal binding site [ion binding]; metal-binding site 746697000725 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 746697000726 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 746697000727 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 746697000728 quinone interaction residues [chemical binding]; other site 746697000729 active site 746697000730 catalytic residues [active] 746697000731 FMN binding site [chemical binding]; other site 746697000732 substrate binding site [chemical binding]; other site 746697000733 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 746697000734 active site 746697000735 NTP binding site [chemical binding]; other site 746697000736 metal binding triad [ion binding]; metal-binding site 746697000737 antibiotic binding site [chemical binding]; other site 746697000738 peptidase T; Region: peptidase-T; TIGR01882 746697000739 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 746697000740 metal binding site [ion binding]; metal-binding site 746697000741 dimer interface [polypeptide binding]; other site 746697000742 Preprotein translocase subunit; Region: YajC; pfam02699 746697000743 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 746697000744 transcription antitermination factor NusB; Region: nusB; TIGR01951 746697000745 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 746697000746 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 746697000747 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 746697000748 NAD binding site [chemical binding]; other site 746697000749 Phe binding site; other site 746697000750 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746697000751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746697000752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697000753 Walker A/P-loop; other site 746697000754 ATP binding site [chemical binding]; other site 746697000755 Q-loop/lid; other site 746697000756 ABC transporter signature motif; other site 746697000757 Walker B; other site 746697000758 D-loop; other site 746697000759 H-loop/switch region; other site 746697000760 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 746697000761 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 746697000762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746697000763 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 746697000764 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 746697000765 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 746697000766 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 746697000767 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 746697000768 Sulfate transporter family; Region: Sulfate_transp; pfam00916 746697000769 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 746697000770 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 746697000771 dimer interface [polypeptide binding]; other site 746697000772 putative tRNA-binding site [nucleotide binding]; other site 746697000773 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 746697000774 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 746697000775 putative catalytic residue [active] 746697000776 metal-dependent hydrolase; Provisional; Region: PRK13291 746697000777 DinB superfamily; Region: DinB_2; pfam12867 746697000778 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 746697000779 active site 746697000780 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 746697000781 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 746697000782 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 746697000783 hydrophobic ligand binding site; other site 746697000784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 746697000785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697000786 Walker A/P-loop; other site 746697000787 ATP binding site [chemical binding]; other site 746697000788 Q-loop/lid; other site 746697000789 ABC transporter signature motif; other site 746697000790 Walker B; other site 746697000791 D-loop; other site 746697000792 H-loop/switch region; other site 746697000793 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 746697000794 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 746697000795 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 746697000796 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746697000797 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746697000798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697000799 Walker A/P-loop; other site 746697000800 ATP binding site [chemical binding]; other site 746697000801 Q-loop/lid; other site 746697000802 ABC transporter signature motif; other site 746697000803 Walker B; other site 746697000804 D-loop; other site 746697000805 H-loop/switch region; other site 746697000806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697000807 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 746697000808 G1 box; other site 746697000809 Walker A/P-loop; other site 746697000810 GTP/Mg2+ binding site [chemical binding]; other site 746697000811 ATP binding site [chemical binding]; other site 746697000812 Switch I region; other site 746697000813 G3 box; other site 746697000814 Switch II region; other site 746697000815 G4 box; other site 746697000816 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 746697000817 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 746697000818 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 746697000819 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 746697000820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697000821 non-specific DNA binding site [nucleotide binding]; other site 746697000822 salt bridge; other site 746697000823 sequence-specific DNA binding site [nucleotide binding]; other site 746697000824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697000825 S-adenosylmethionine binding site [chemical binding]; other site 746697000826 Helix-turn-helix domain; Region: HTH_18; pfam12833 746697000827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697000828 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697000829 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697000830 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697000831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697000832 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746697000833 Walker A motif; other site 746697000834 ATP binding site [chemical binding]; other site 746697000835 Walker B motif; other site 746697000836 arginine finger; other site 746697000837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 746697000838 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 746697000839 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 746697000840 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697000841 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 746697000842 PA/protease or protease-like domain interface [polypeptide binding]; other site 746697000843 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 746697000844 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697000845 metal binding site [ion binding]; metal-binding site 746697000846 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 746697000847 Response regulator receiver domain; Region: Response_reg; pfam00072 746697000848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697000849 active site 746697000850 phosphorylation site [posttranslational modification] 746697000851 intermolecular recognition site; other site 746697000852 dimerization interface [polypeptide binding]; other site 746697000853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697000854 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746697000855 Walker A motif; other site 746697000856 ATP binding site [chemical binding]; other site 746697000857 Walker B motif; other site 746697000858 arginine finger; other site 746697000859 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 746697000860 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 746697000861 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 746697000862 Walker A/P-loop; other site 746697000863 ATP binding site [chemical binding]; other site 746697000864 Q-loop/lid; other site 746697000865 ABC transporter signature motif; other site 746697000866 Walker B; other site 746697000867 D-loop; other site 746697000868 H-loop/switch region; other site 746697000869 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 746697000870 chaperone protein DnaJ; Provisional; Region: PRK14289 746697000871 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 746697000872 HSP70 interaction site [polypeptide binding]; other site 746697000873 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 746697000874 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 746697000875 dimer interface [polypeptide binding]; other site 746697000876 GrpE; Region: GrpE; pfam01025 746697000877 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 746697000878 dimer interface [polypeptide binding]; other site 746697000879 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 746697000880 YceI-like domain; Region: YceI; pfam04264 746697000881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697000882 TIGR01777 family protein; Region: yfcH 746697000883 NAD(P) binding site [chemical binding]; other site 746697000884 active site 746697000885 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 746697000886 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 746697000887 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 746697000888 homodimer interface [polypeptide binding]; other site 746697000889 substrate-cofactor binding pocket; other site 746697000890 catalytic residue [active] 746697000891 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 746697000892 metal binding site [ion binding]; metal-binding site 746697000893 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697000894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697000895 DNA binding residues [nucleotide binding] 746697000896 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 746697000897 active site 746697000898 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 746697000899 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 746697000900 Sel1-like repeats; Region: SEL1; smart00671 746697000901 Ion transport protein; Region: Ion_trans; pfam00520 746697000902 Ion channel; Region: Ion_trans_2; pfam07885 746697000903 CHASE2 domain; Region: CHASE2; pfam05226 746697000904 Peptidase family M49; Region: Peptidase_M49; pfam03571 746697000905 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 746697000906 putative hydrophobic ligand binding site [chemical binding]; other site 746697000907 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 746697000908 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 746697000909 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 746697000910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697000911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746697000912 putative substrate translocation pore; other site 746697000913 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 746697000914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746697000915 putative DNA binding site [nucleotide binding]; other site 746697000916 putative Zn2+ binding site [ion binding]; other site 746697000917 AsnC family; Region: AsnC_trans_reg; pfam01037 746697000918 RES domain; Region: RES; pfam08808 746697000919 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 746697000920 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 746697000921 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 746697000922 B12 binding site [chemical binding]; other site 746697000923 cobalt ligand [ion binding]; other site 746697000924 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 746697000925 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 746697000926 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 746697000927 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000928 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000929 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697000930 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 746697000931 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 746697000932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 746697000933 intersubunit interface [polypeptide binding]; other site 746697000934 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 746697000935 active site 746697000936 dimer interface [polypeptide binding]; other site 746697000937 peptide chain release factor 1; Validated; Region: prfA; PRK00591 746697000938 PCRF domain; Region: PCRF; pfam03462 746697000939 RF-1 domain; Region: RF-1; pfam00472 746697000940 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 746697000941 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 746697000942 dimerization interface [polypeptide binding]; other site 746697000943 ATP binding site [chemical binding]; other site 746697000944 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697000945 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 746697000946 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 746697000947 Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; pfam10614 746697000948 Curli assembly protein CsgE; Region: CsgE; cl08115 746697000949 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 746697000950 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 746697000951 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 746697000952 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 746697000953 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 746697000954 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 746697000955 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 746697000956 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 746697000957 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697000958 active site 746697000959 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 746697000960 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 746697000961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697000962 S-adenosylmethionine binding site [chemical binding]; other site 746697000963 triosephosphate isomerase; Provisional; Region: PRK14567 746697000964 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 746697000965 substrate binding site [chemical binding]; other site 746697000966 dimer interface [polypeptide binding]; other site 746697000967 catalytic triad [active] 746697000968 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697000969 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697000970 catalytic residues [active] 746697000971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 746697000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 746697000973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746697000974 putative PBP binding loops; other site 746697000975 dimer interface [polypeptide binding]; other site 746697000976 ABC-ATPase subunit interface; other site 746697000977 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 746697000978 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 746697000979 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 746697000980 dihydropteroate synthase; Region: DHPS; TIGR01496 746697000981 substrate binding pocket [chemical binding]; other site 746697000982 dimer interface [polypeptide binding]; other site 746697000983 inhibitor binding site; inhibition site 746697000984 Uncharacterized conserved protein [Function unknown]; Region: COG1624 746697000985 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 746697000986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746697000987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746697000988 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 746697000989 Walker A/P-loop; other site 746697000990 ATP binding site [chemical binding]; other site 746697000991 Q-loop/lid; other site 746697000992 ABC transporter signature motif; other site 746697000993 Walker B; other site 746697000994 D-loop; other site 746697000995 H-loop/switch region; other site 746697000996 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 746697000997 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 746697000998 dimerization interface 3.5A [polypeptide binding]; other site 746697000999 active site 746697001000 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 746697001001 active site 746697001002 metal binding site [ion binding]; metal-binding site 746697001003 homotetramer interface [polypeptide binding]; other site 746697001004 Domain of unknown function (DUF4293); Region: DUF4293; pfam14126 746697001005 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 746697001006 transcription termination factor Rho; Provisional; Region: PRK12608 746697001007 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 746697001008 RNA binding site [nucleotide binding]; other site 746697001009 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 746697001010 multimer interface [polypeptide binding]; other site 746697001011 Walker A motif; other site 746697001012 ATP binding site [chemical binding]; other site 746697001013 Walker B motif; other site 746697001014 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697001015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697001016 active site 746697001017 phosphorylation site [posttranslational modification] 746697001018 intermolecular recognition site; other site 746697001019 dimerization interface [polypeptide binding]; other site 746697001020 LytTr DNA-binding domain; Region: LytTR; smart00850 746697001021 Histidine kinase; Region: His_kinase; pfam06580 746697001022 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 746697001023 Galactose oxidase, central domain; Region: Kelch_3; cl02701 746697001024 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 746697001025 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 746697001026 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001027 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 746697001028 putative active site [active] 746697001029 Zn binding site [ion binding]; other site 746697001030 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 746697001031 active site 746697001032 Ap6A binding site [chemical binding]; other site 746697001033 nudix motif; other site 746697001034 metal binding site [ion binding]; metal-binding site 746697001035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697001036 active site 746697001037 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 746697001038 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 746697001039 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 746697001040 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 746697001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697001042 Walker A motif; other site 746697001043 ATP binding site [chemical binding]; other site 746697001044 Walker B motif; other site 746697001045 arginine finger; other site 746697001046 Peptidase family M41; Region: Peptidase_M41; pfam01434 746697001047 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 746697001048 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 746697001049 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 746697001050 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 746697001051 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 746697001052 acyl-CoA binding pocket [chemical binding]; other site 746697001053 CoA binding site [chemical binding]; other site 746697001054 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 746697001055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697001056 active site 746697001057 HIGH motif; other site 746697001058 nucleotide binding site [chemical binding]; other site 746697001059 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 746697001060 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 746697001061 active site 746697001062 KMSKS motif; other site 746697001063 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 746697001064 tRNA binding surface [nucleotide binding]; other site 746697001065 anticodon binding site; other site 746697001066 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 746697001067 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 746697001068 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 746697001069 catalytic motif [active] 746697001070 Catalytic residue [active] 746697001071 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 746697001072 aspartate aminotransferase; Provisional; Region: PRK07568 746697001073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746697001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697001075 homodimer interface [polypeptide binding]; other site 746697001076 catalytic residue [active] 746697001077 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 746697001078 FAD binding domain; Region: FAD_binding_4; pfam01565 746697001079 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 746697001080 Fasciclin domain; Region: Fasciclin; pfam02469 746697001081 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697001082 active site 746697001083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697001084 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697001085 lipoyl synthase; Provisional; Region: PRK05481 746697001086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697001087 FeS/SAM binding site; other site 746697001088 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 746697001089 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 746697001090 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 746697001091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697001092 dimer interface [polypeptide binding]; other site 746697001093 phosphorylation site [posttranslational modification] 746697001094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697001095 ATP binding site [chemical binding]; other site 746697001096 Mg2+ binding site [ion binding]; other site 746697001097 G-X-G motif; other site 746697001098 Response regulator receiver domain; Region: Response_reg; pfam00072 746697001099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697001100 active site 746697001101 phosphorylation site [posttranslational modification] 746697001102 intermolecular recognition site; other site 746697001103 dimerization interface [polypeptide binding]; other site 746697001104 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 746697001105 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 746697001106 Uncharacterized conserved protein [Function unknown]; Region: COG0327 746697001107 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 746697001108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 746697001109 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 746697001110 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 746697001111 Putative zinc ribbon domain; Region: DUF164; pfam02591 746697001112 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 746697001113 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746697001114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001115 S-adenosylmethionine binding site [chemical binding]; other site 746697001116 Predicted acetyltransferase [General function prediction only]; Region: COG2388 746697001117 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 746697001118 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 746697001119 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 746697001120 kynureninase; Region: kynureninase; TIGR01814 746697001121 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697001122 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697001123 catalytic residue [active] 746697001124 catalytic residue [active] 746697001125 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 746697001126 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 746697001127 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 746697001128 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 746697001129 homotrimer interaction site [polypeptide binding]; other site 746697001130 putative active site [active] 746697001131 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 746697001132 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 746697001133 NAD binding site [chemical binding]; other site 746697001134 catalytic residues [active] 746697001135 short chain dehydrogenase; Provisional; Region: PRK08339 746697001136 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 746697001137 putative NAD(P) binding site [chemical binding]; other site 746697001138 putative active site [active] 746697001139 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 746697001140 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 746697001141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697001142 putative substrate translocation pore; other site 746697001143 POT family; Region: PTR2; cl17359 746697001144 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 746697001145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001146 S-adenosylmethionine binding site [chemical binding]; other site 746697001147 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 746697001148 active site 746697001149 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 746697001150 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 746697001151 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 746697001152 Zn binding site [ion binding]; other site 746697001153 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001154 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001155 Family description; Region: VCBS; pfam13517 746697001156 Family description; Region: VCBS; pfam13517 746697001157 Family description; Region: VCBS; pfam13517 746697001158 Family description; Region: VCBS; pfam13517 746697001159 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001160 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 746697001161 active site pocket [active] 746697001162 oxyanion hole [active] 746697001163 catalytic triad [active] 746697001164 active site nucleophile [active] 746697001165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697001166 Coenzyme A binding pocket [chemical binding]; other site 746697001167 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 746697001168 BNR repeat-like domain; Region: BNR_2; pfam13088 746697001169 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001170 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 746697001171 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 746697001172 phosphoglyceromutase; Provisional; Region: PRK05434 746697001173 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746697001174 catalytic residues [active] 746697001175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 746697001176 active site 746697001177 motif I; other site 746697001178 motif II; other site 746697001179 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 746697001180 active site 746697001181 Methyltransferase domain; Region: Methyltransf_23; pfam13489 746697001182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001183 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 746697001184 ApbE family; Region: ApbE; pfam02424 746697001185 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 746697001186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 746697001187 catalytic loop [active] 746697001188 iron binding site [ion binding]; other site 746697001189 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 746697001190 FAD binding pocket [chemical binding]; other site 746697001191 FAD binding motif [chemical binding]; other site 746697001192 phosphate binding motif [ion binding]; other site 746697001193 beta-alpha-beta structure motif; other site 746697001194 NAD binding pocket [chemical binding]; other site 746697001195 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 746697001196 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 746697001197 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 746697001198 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 746697001199 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 746697001200 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 746697001201 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 746697001202 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697001203 binding surface 746697001204 TPR motif; other site 746697001205 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 746697001206 Protein of unknown function (DUF3667); Region: DUF3667; pfam12412 746697001207 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 746697001208 NRDE protein; Region: NRDE; cl01315 746697001209 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 746697001210 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 746697001211 Glutamate binding site [chemical binding]; other site 746697001212 NAD binding site [chemical binding]; other site 746697001213 catalytic residues [active] 746697001214 Outer membrane protein Omp28; Region: Omp28; pfam11551 746697001215 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697001216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697001217 catalytic residues [active] 746697001218 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001219 Outer membrane protein Omp28; Region: Omp28; pfam11551 746697001220 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001221 Outer membrane protein Omp28; Region: Omp28; pfam11551 746697001222 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001223 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 746697001224 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 746697001225 dimer interface [polypeptide binding]; other site 746697001226 ADP-ribose binding site [chemical binding]; other site 746697001227 active site 746697001228 nudix motif; other site 746697001229 metal binding site [ion binding]; metal-binding site 746697001230 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 746697001231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001232 S-adenosylmethionine binding site [chemical binding]; other site 746697001233 Fatty acid desaturase; Region: FA_desaturase; pfam00487 746697001234 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 746697001235 putative di-iron ligands [ion binding]; other site 746697001236 aspartate aminotransferase; Provisional; Region: PRK05764 746697001237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746697001238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697001239 homodimer interface [polypeptide binding]; other site 746697001240 catalytic residue [active] 746697001241 CARDB; Region: CARDB; pfam07705 746697001242 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001243 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 746697001244 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 746697001245 ATP-grasp domain; Region: ATP-grasp; pfam02222 746697001246 Cation transport protein; Region: TrkH; cl17365 746697001247 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 746697001248 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 746697001249 TrkA-N domain; Region: TrkA_N; pfam02254 746697001250 TrkA-C domain; Region: TrkA_C; pfam02080 746697001251 TrkA-N domain; Region: TrkA_N; pfam02254 746697001252 TrkA-C domain; Region: TrkA_C; pfam02080 746697001253 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 746697001254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001255 S-adenosylmethionine binding site [chemical binding]; other site 746697001256 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697001257 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 746697001258 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746697001259 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 746697001260 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697001261 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 746697001262 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 746697001263 active site 746697001264 intersubunit interface [polypeptide binding]; other site 746697001265 zinc binding site [ion binding]; other site 746697001266 Na+ binding site [ion binding]; other site 746697001267 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 746697001268 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 746697001269 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 746697001270 16S/18S rRNA binding site [nucleotide binding]; other site 746697001271 S13e-L30e interaction site [polypeptide binding]; other site 746697001272 25S rRNA binding site [nucleotide binding]; other site 746697001273 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 746697001274 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 746697001275 RNase E interface [polypeptide binding]; other site 746697001276 trimer interface [polypeptide binding]; other site 746697001277 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 746697001278 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 746697001279 RNase E interface [polypeptide binding]; other site 746697001280 trimer interface [polypeptide binding]; other site 746697001281 active site 746697001282 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 746697001283 nucleic acid binding region [nucleotide binding]; other site 746697001284 G-X-X-G motif; other site 746697001285 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 746697001286 RNA binding site [nucleotide binding]; other site 746697001287 domain interface; other site 746697001288 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697001289 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697001290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697001291 DNA binding residues [nucleotide binding] 746697001292 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 746697001293 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 746697001294 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697001295 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 746697001296 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697001297 DNA binding residues [nucleotide binding] 746697001298 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 746697001299 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 746697001300 substrate binding site [chemical binding]; other site 746697001301 hexamer interface [polypeptide binding]; other site 746697001302 metal binding site [ion binding]; metal-binding site 746697001303 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 746697001304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 746697001305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697001306 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 746697001307 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 746697001308 starch binding outer membrane protein SusD; Region: SusD; cl17845 746697001309 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 746697001310 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001311 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697001312 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697001313 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 746697001314 dimerization interface [polypeptide binding]; other site 746697001315 Heavy-metal-associated domain; Region: HMA; pfam00403 746697001316 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001317 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697001318 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697001319 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 746697001320 metal-binding site [ion binding] 746697001321 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 746697001322 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 746697001323 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697001324 motif II; other site 746697001325 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 746697001326 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 746697001327 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 746697001328 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 746697001329 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 746697001330 GAF domain; Region: GAF_2; pfam13185 746697001331 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746697001332 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 746697001333 FtsX-like permease family; Region: FtsX; pfam02687 746697001334 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 746697001335 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 746697001336 purine monophosphate binding site [chemical binding]; other site 746697001337 dimer interface [polypeptide binding]; other site 746697001338 putative catalytic residues [active] 746697001339 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 746697001340 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 746697001341 rod shape-determining protein MreB; Provisional; Region: PRK13927 746697001342 MreB and similar proteins; Region: MreB_like; cd10225 746697001343 nucleotide binding site [chemical binding]; other site 746697001344 Mg binding site [ion binding]; other site 746697001345 putative protofilament interaction site [polypeptide binding]; other site 746697001346 RodZ interaction site [polypeptide binding]; other site 746697001347 rod shape-determining protein MreC; Provisional; Region: PRK13922 746697001348 rod shape-determining protein MreC; Region: MreC; pfam04085 746697001349 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 746697001350 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 746697001351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 746697001352 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 746697001353 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 746697001354 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 746697001355 active site 746697001356 substrate binding site [chemical binding]; other site 746697001357 Mg2+ binding site [ion binding]; other site 746697001358 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 746697001359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 746697001360 dimer interface [polypeptide binding]; other site 746697001361 conserved gate region; other site 746697001362 putative PBP binding loops; other site 746697001363 ABC-ATPase subunit interface; other site 746697001364 C-terminal peptidase (prc); Region: prc; TIGR00225 746697001365 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 746697001366 protein binding site [polypeptide binding]; other site 746697001367 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 746697001368 Catalytic dyad [active] 746697001369 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 746697001370 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 746697001371 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 746697001372 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 746697001373 active site 746697001374 (T/H)XGH motif; other site 746697001375 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 746697001376 prolyl-tRNA synthetase; Provisional; Region: PRK08661 746697001377 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 746697001378 dimer interface [polypeptide binding]; other site 746697001379 motif 1; other site 746697001380 active site 746697001381 motif 2; other site 746697001382 motif 3; other site 746697001383 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 746697001384 anticodon binding site; other site 746697001385 zinc-binding site [ion binding]; other site 746697001386 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 746697001387 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 746697001388 GTP cyclohydrolase I; Provisional; Region: PLN03044 746697001389 active site 746697001390 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 746697001391 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 746697001392 active site 746697001393 HIGH motif; other site 746697001394 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 746697001395 KMSKS motif; other site 746697001396 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 746697001397 Haemolytic domain; Region: Haemolytic; pfam01809 746697001398 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 746697001399 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 746697001400 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 746697001401 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 746697001402 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 746697001403 Protein export membrane protein; Region: SecD_SecF; pfam02355 746697001404 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 746697001405 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 746697001406 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 746697001407 active site 746697001408 dimer interface [polypeptide binding]; other site 746697001409 effector binding site; other site 746697001410 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 746697001411 malate dehydrogenase; Reviewed; Region: PRK06223 746697001412 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 746697001413 dimer interface [polypeptide binding]; other site 746697001414 NAD(P) binding site [chemical binding]; other site 746697001415 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746697001416 substrate binding site [chemical binding]; other site 746697001417 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 746697001418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697001419 Mg2+ binding site [ion binding]; other site 746697001420 G-X-G motif; other site 746697001421 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 746697001422 anchoring element; other site 746697001423 dimer interface [polypeptide binding]; other site 746697001424 ATP binding site [chemical binding]; other site 746697001425 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 746697001426 active site 746697001427 putative metal-binding site [ion binding]; other site 746697001428 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 746697001429 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 746697001430 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 746697001431 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 746697001432 AAA-like domain; Region: AAA_10; pfam12846 746697001433 Zonular occludens toxin (Zot); Region: Zot; cl17485 746697001434 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 746697001435 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 746697001436 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697001437 putative metal binding site [ion binding]; other site 746697001438 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 746697001439 Uncharacterized conserved protein [Function unknown]; Region: COG3339 746697001440 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185 746697001441 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 746697001442 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 746697001443 homodimer interface [polypeptide binding]; other site 746697001444 NADP binding site [chemical binding]; other site 746697001445 substrate binding site [chemical binding]; other site 746697001446 signal recognition particle protein; Provisional; Region: PRK10867 746697001447 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 746697001448 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 746697001449 P loop; other site 746697001450 GTP binding site [chemical binding]; other site 746697001451 Signal peptide binding domain; Region: SRP_SPB; pfam02978 746697001452 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 746697001453 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 746697001454 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697001455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697001456 Coenzyme A binding pocket [chemical binding]; other site 746697001457 Spore germination protein; Region: Spore_permease; cl17796 746697001458 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746697001459 dimerization interface [polypeptide binding]; other site 746697001460 putative DNA binding site [nucleotide binding]; other site 746697001461 putative Zn2+ binding site [ion binding]; other site 746697001462 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746697001463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001464 S-adenosylmethionine binding site [chemical binding]; other site 746697001465 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 746697001466 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 746697001467 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 746697001468 ATP binding site [chemical binding]; other site 746697001469 Mg++ binding site [ion binding]; other site 746697001470 motif III; other site 746697001471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697001472 nucleotide binding region [chemical binding]; other site 746697001473 ATP-binding site [chemical binding]; other site 746697001474 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 746697001475 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001476 RNA polymerase sigma factor; Provisional; Region: PRK11922 746697001477 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697001478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697001479 DNA binding residues [nucleotide binding] 746697001480 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001481 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697001483 binding surface 746697001484 TPR motif; other site 746697001485 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001486 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 746697001488 Histidine kinase; Region: HisKA_2; pfam07568 746697001489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697001490 Mg2+ binding site [ion binding]; other site 746697001491 G-X-G motif; other site 746697001492 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697001493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697001494 active site 746697001495 phosphorylation site [posttranslational modification] 746697001496 intermolecular recognition site; other site 746697001497 dimerization interface [polypeptide binding]; other site 746697001498 LytTr DNA-binding domain; Region: LytTR; smart00850 746697001499 SnoaL-like domain; Region: SnoaL_2; pfam12680 746697001500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697001501 NAD(P) binding site [chemical binding]; other site 746697001502 active site 746697001503 SnoaL-like domain; Region: SnoaL_3; pfam13474 746697001504 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 746697001505 putative active site [active] 746697001506 homotrimer interaction site [polypeptide binding]; other site 746697001507 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 746697001508 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697001509 M28 Zn-Peptidases; Region: M28_like_4; cd08015 746697001510 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697001511 metal binding site [ion binding]; metal-binding site 746697001512 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 746697001513 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 746697001514 active site 746697001515 dimer interface [polypeptide binding]; other site 746697001516 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 746697001517 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 746697001518 active site clefts [active] 746697001519 zinc binding site [ion binding]; other site 746697001520 dimer interface [polypeptide binding]; other site 746697001521 Fasciclin domain; Region: Fasciclin; pfam02469 746697001522 Fasciclin domain; Region: Fasciclin; pfam02469 746697001523 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697001524 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 746697001525 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697001526 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697001527 metal binding site [ion binding]; metal-binding site 746697001528 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 746697001529 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 746697001530 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697001531 active site 746697001532 HIGH motif; other site 746697001533 nucleotide binding site [chemical binding]; other site 746697001534 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 746697001535 KMSK motif region; other site 746697001536 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 746697001537 tRNA binding surface [nucleotide binding]; other site 746697001538 anticodon binding site; other site 746697001539 MarC family integral membrane protein; Region: MarC; cl00919 746697001540 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 746697001541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697001542 NAD(P) binding site [chemical binding]; other site 746697001543 active site 746697001544 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 746697001545 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 746697001546 Amidinotransferase; Region: Amidinotransf; pfam02274 746697001547 DinB family; Region: DinB; cl17821 746697001548 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 746697001549 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697001550 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 746697001551 ApbE family; Region: ApbE; pfam02424 746697001552 Domain of unknown function (DUF4266); Region: DUF4266; pfam14086 746697001553 Protein of unknown function (DUF3570); Region: DUF3570; pfam12094 746697001554 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746697001555 active site residue [active] 746697001556 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746697001557 active site residue [active] 746697001558 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 746697001559 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 746697001560 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 746697001561 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 746697001562 Glutamine amidotransferase class-I; Region: GATase; pfam00117 746697001563 glutamine binding [chemical binding]; other site 746697001564 catalytic triad [active] 746697001565 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 746697001566 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 746697001567 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 746697001568 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 746697001569 active site 746697001570 ribulose/triose binding site [chemical binding]; other site 746697001571 phosphate binding site [ion binding]; other site 746697001572 substrate (anthranilate) binding pocket [chemical binding]; other site 746697001573 product (indole) binding pocket [chemical binding]; other site 746697001574 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 746697001575 active site 746697001576 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 746697001577 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 746697001578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697001579 catalytic residue [active] 746697001580 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 746697001581 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 746697001582 substrate binding site [chemical binding]; other site 746697001583 active site 746697001584 catalytic residues [active] 746697001585 heterodimer interface [polypeptide binding]; other site 746697001586 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 746697001587 homodimer interface [polypeptide binding]; other site 746697001588 catalytic residues [active] 746697001589 NAD binding site [chemical binding]; other site 746697001590 substrate binding pocket [chemical binding]; other site 746697001591 flexible flap; other site 746697001592 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 746697001593 pantothenate kinase; Reviewed; Region: PRK13320 746697001594 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 746697001595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697001597 binding surface 746697001598 TPR motif; other site 746697001599 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 746697001600 Domain of unknown function DUF21; Region: DUF21; pfam01595 746697001601 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 746697001602 Transporter associated domain; Region: CorC_HlyC; smart01091 746697001603 SurA N-terminal domain; Region: SurA_N_3; cl07813 746697001604 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 746697001605 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 746697001606 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 746697001607 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 746697001608 Uncharacterized conserved protein [Function unknown]; Region: COG3189 746697001609 Protein of unknown function, DUF481; Region: DUF481; pfam04338 746697001610 alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169 746697001611 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 746697001612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697001613 FeS/SAM binding site; other site 746697001614 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 746697001615 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 746697001616 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 746697001617 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001618 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697001619 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697001620 Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771 746697001621 starch binding outer membrane protein SusD; Region: SusD; cd08977 746697001622 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 746697001623 Na binding site [ion binding]; other site 746697001624 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 746697001625 active site 746697001626 metal binding site [ion binding]; metal-binding site 746697001627 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 746697001628 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746697001629 active site residue [active] 746697001630 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 746697001631 purine nucleoside phosphorylase; Provisional; Region: PRK08202 746697001632 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 746697001633 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 746697001634 Protein of unknown function, DUF547; Region: DUF547; pfam04784 746697001635 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 746697001636 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 746697001637 Probable Catalytic site; other site 746697001638 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 746697001639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 746697001640 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697001641 4Fe-4S binding domain; Region: Fer4_5; pfam12801 746697001642 Fasciclin domain; Region: Fasciclin; pfam02469 746697001643 Fasciclin domain; Region: Fasciclin; pfam02469 746697001644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697001645 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 746697001646 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 746697001647 Ligand binding site; other site 746697001648 Putative Catalytic site; other site 746697001649 DXD motif; other site 746697001650 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 746697001651 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 746697001652 DXD motif; other site 746697001653 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 746697001654 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 746697001655 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746697001656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697001657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746697001658 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 746697001659 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 746697001660 Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574 746697001661 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 746697001662 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001663 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 746697001664 four helix bundle protein; Region: TIGR02436 746697001665 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 746697001666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697001667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697001668 DNA binding residues [nucleotide binding] 746697001669 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 746697001670 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 746697001671 dimer interface [polypeptide binding]; other site 746697001672 putative anticodon binding site; other site 746697001673 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 746697001674 motif 1; other site 746697001675 active site 746697001676 motif 2; other site 746697001677 motif 3; other site 746697001678 adenylate kinase; Reviewed; Region: adk; PRK00279 746697001679 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 746697001680 AMP-binding site [chemical binding]; other site 746697001681 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 746697001682 GTPase CgtA; Reviewed; Region: obgE; PRK12299 746697001683 GTP1/OBG; Region: GTP1_OBG; pfam01018 746697001684 Obg GTPase; Region: Obg; cd01898 746697001685 G1 box; other site 746697001686 GTP/Mg2+ binding site [chemical binding]; other site 746697001687 Switch I region; other site 746697001688 G2 box; other site 746697001689 G3 box; other site 746697001690 Switch II region; other site 746697001691 G4 box; other site 746697001692 G5 box; other site 746697001693 Family description; Region: VCBS; pfam13517 746697001694 Family description; Region: VCBS; pfam13517 746697001695 Family description; Region: VCBS; pfam13517 746697001696 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001697 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 746697001698 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001699 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 746697001700 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 746697001701 alpha subunit interface [polypeptide binding]; other site 746697001702 TPP binding site [chemical binding]; other site 746697001703 heterodimer interface [polypeptide binding]; other site 746697001704 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746697001705 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 746697001706 Ligand binding site [chemical binding]; other site 746697001707 Electron transfer flavoprotein domain; Region: ETF; pfam01012 746697001708 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 746697001709 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 746697001710 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 746697001711 Bifunctional nuclease; Region: DNase-RNase; pfam02577 746697001712 UvrB/uvrC motif; Region: UVR; pfam02151 746697001713 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 746697001714 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 746697001715 Nucleoside recognition; Region: Gate; pfam07670 746697001716 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 746697001717 thymidylate synthase; Reviewed; Region: thyA; PRK01827 746697001718 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 746697001719 dimerization interface [polypeptide binding]; other site 746697001720 active site 746697001721 Gram-negative bacterial tonB protein; Region: TonB; cl10048 746697001722 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 746697001723 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 746697001724 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 746697001725 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 746697001726 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 746697001727 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 746697001728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697001729 catalytic residue [active] 746697001730 catalytic residue [active] 746697001731 2TM domain; Region: 2TM; pfam13239 746697001732 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 746697001733 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 746697001734 folate binding site [chemical binding]; other site 746697001735 NADP+ binding site [chemical binding]; other site 746697001736 Protein of unknown function (DUF664); Region: DUF664; pfam04978 746697001737 DinB superfamily; Region: DinB_2; pfam12867 746697001738 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 746697001739 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 746697001740 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 746697001741 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 746697001742 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697001743 catalytic residue [active] 746697001744 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 746697001745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697001746 S-adenosylmethionine binding site [chemical binding]; other site 746697001747 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 746697001748 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 746697001749 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 746697001750 NAD binding site [chemical binding]; other site 746697001751 homodimer interface [polypeptide binding]; other site 746697001752 active site 746697001753 substrate binding site [chemical binding]; other site 746697001754 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 746697001755 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 746697001756 inhibitor-cofactor binding pocket; inhibition site 746697001757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697001758 catalytic residue [active] 746697001759 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 746697001760 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 746697001761 polyphosphate kinase; Provisional; Region: PRK05443 746697001762 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 746697001763 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 746697001764 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 746697001765 domain interface [polypeptide binding]; other site 746697001766 active site 746697001767 catalytic site [active] 746697001768 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 746697001769 domain interface [polypeptide binding]; other site 746697001770 active site 746697001771 catalytic site [active] 746697001772 Uncharacterized conserved protein [Function unknown]; Region: COG4850 746697001773 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 746697001774 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 746697001775 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 746697001776 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 746697001777 dimer interface [polypeptide binding]; other site 746697001778 substrate binding site [chemical binding]; other site 746697001779 metal binding sites [ion binding]; metal-binding site 746697001780 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 746697001781 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 746697001782 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 746697001783 cofactor binding site; other site 746697001784 DNA binding site [nucleotide binding] 746697001785 substrate interaction site [chemical binding]; other site 746697001786 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 746697001787 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 746697001788 active site 746697001789 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746697001790 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697001791 non-specific DNA binding site [nucleotide binding]; other site 746697001792 salt bridge; other site 746697001793 sequence-specific DNA binding site [nucleotide binding]; other site 746697001794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001795 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697001796 Domain of unknown function DUF11; Region: DUF11; cl17728 746697001797 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 746697001798 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 746697001799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697001800 binding surface 746697001801 TPR motif; other site 746697001802 TPR repeat; Region: TPR_11; pfam13414 746697001803 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697001804 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697001805 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697001806 ligand binding site [chemical binding]; other site 746697001807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697001809 binding surface 746697001810 TPR motif; other site 746697001811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697001812 HYR domain; Region: HYR; pfam02494 746697001813 HYR domain; Region: HYR; pfam02494 746697001814 HYR domain; Region: HYR; pfam02494 746697001815 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001816 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746697001817 active site 746697001818 catalytic site [active] 746697001819 substrate binding site [chemical binding]; other site 746697001820 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 746697001821 GIY-YIG motif/motif A; other site 746697001822 active site 746697001823 catalytic site [active] 746697001824 putative DNA binding site [nucleotide binding]; other site 746697001825 metal binding site [ion binding]; metal-binding site 746697001826 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 746697001827 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697001828 motif II; other site 746697001829 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001830 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 746697001831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 746697001832 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 746697001833 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 746697001834 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 746697001835 active site 746697001836 FMN binding site [chemical binding]; other site 746697001837 substrate binding site [chemical binding]; other site 746697001838 homotetramer interface [polypeptide binding]; other site 746697001839 catalytic residue [active] 746697001840 aconitate hydratase; Validated; Region: PRK09277 746697001841 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 746697001842 substrate binding site [chemical binding]; other site 746697001843 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 746697001844 ligand binding site [chemical binding]; other site 746697001845 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 746697001846 substrate binding site [chemical binding]; other site 746697001847 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697001848 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697001849 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 746697001850 N-terminal plug; other site 746697001851 ligand-binding site [chemical binding]; other site 746697001852 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 746697001853 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 746697001854 intersubunit interface [polypeptide binding]; other site 746697001855 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 746697001856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 746697001857 ABC-ATPase subunit interface; other site 746697001858 dimer interface [polypeptide binding]; other site 746697001859 putative PBP binding regions; other site 746697001860 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 746697001861 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 746697001862 Walker A/P-loop; other site 746697001863 ATP binding site [chemical binding]; other site 746697001864 Q-loop/lid; other site 746697001865 ABC transporter signature motif; other site 746697001866 Walker B; other site 746697001867 D-loop; other site 746697001868 H-loop/switch region; other site 746697001869 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 746697001870 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 746697001871 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 746697001872 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 746697001873 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 746697001874 flavoprotein, HI0933 family; Region: TIGR00275 746697001875 hydroxyglutarate oxidase; Provisional; Region: PRK11728 746697001876 tyrosine decarboxylase; Region: PLN02880 746697001877 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 746697001878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697001879 catalytic residue [active] 746697001880 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697001881 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697001882 putative catalytic site [active] 746697001883 putative metal binding site [ion binding]; other site 746697001884 putative phosphate binding site [ion binding]; other site 746697001885 MarR family; Region: MarR_2; pfam12802 746697001886 META domain; Region: META; pfam03724 746697001887 META domain; Region: META; pfam03724 746697001888 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 746697001889 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 746697001890 active site 746697001891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697001892 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 746697001893 NAD(P) binding site [chemical binding]; other site 746697001894 active site 746697001895 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 746697001896 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 746697001897 putative active site [active] 746697001898 catalytic site [active] 746697001899 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 746697001900 putative active site [active] 746697001901 catalytic site [active] 746697001902 Outer membrane efflux protein; Region: OEP; pfam02321 746697001903 Outer membrane efflux protein; Region: OEP; pfam02321 746697001904 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 746697001905 Predicted transcriptional regulators [Transcription]; Region: COG1510 746697001906 hypothetical protein; Provisional; Region: PRK08201 746697001907 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 746697001908 metal binding site [ion binding]; metal-binding site 746697001909 putative dimer interface [polypeptide binding]; other site 746697001910 LytTr DNA-binding domain; Region: LytTR; smart00850 746697001911 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 746697001912 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 746697001913 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 746697001914 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 746697001915 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 746697001916 PhnA protein; Region: PhnA; pfam03831 746697001917 Penicillinase repressor; Region: Pencillinase_R; cl17580 746697001918 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 746697001919 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 746697001920 Zn binding site [ion binding]; other site 746697001921 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 746697001922 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746697001923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697001924 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697001925 ABC transporter; Region: ABC_tran_2; pfam12848 746697001926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697001927 C4-type Zn-finger protein [General function prediction only]; Region: COG1779 746697001928 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 746697001929 TrkA-N domain; Region: TrkA_N; pfam02254 746697001930 gliding motility associated protien GldN; Region: GldN; TIGR03523 746697001931 gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517 746697001932 GldM N-terminal domain; Region: GldM_N; pfam12081 746697001933 GldM C-terminal domain; Region: GldM_C; pfam12080 746697001934 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 746697001935 gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525 746697001936 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 746697001937 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 746697001938 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 746697001939 putative active site [active] 746697001940 putative metal binding site [ion binding]; other site 746697001941 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 746697001942 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 746697001943 active site 746697001944 interdomain interaction site; other site 746697001945 putative metal-binding site [ion binding]; other site 746697001946 nucleotide binding site [chemical binding]; other site 746697001947 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 746697001948 domain I; other site 746697001949 DNA binding groove [nucleotide binding] 746697001950 phosphate binding site [ion binding]; other site 746697001951 domain II; other site 746697001952 domain III; other site 746697001953 nucleotide binding site [chemical binding]; other site 746697001954 catalytic site [active] 746697001955 domain IV; other site 746697001956 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 746697001957 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 746697001958 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 746697001959 TRAM domain; Region: TRAM; pfam01938 746697001960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697001961 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746697001962 Walker A motif; other site 746697001963 ATP binding site [chemical binding]; other site 746697001964 Walker B motif; other site 746697001965 arginine finger; other site 746697001966 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 746697001967 Lipopolysaccharide-assembly; Region: LptE; pfam04390 746697001968 Preprotein translocase SecG subunit; Region: SecG; pfam03840 746697001969 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 746697001970 oligomerisation interface [polypeptide binding]; other site 746697001971 mobile loop; other site 746697001972 roof hairpin; other site 746697001973 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 746697001974 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 746697001975 ring oligomerisation interface [polypeptide binding]; other site 746697001976 ATP/Mg binding site [chemical binding]; other site 746697001977 stacking interactions; other site 746697001978 hinge regions; other site 746697001979 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 746697001980 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697001981 metal binding site [ion binding]; metal-binding site 746697001982 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 746697001983 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 746697001984 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 746697001985 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 746697001986 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 746697001987 Predicted amidohydrolase [General function prediction only]; Region: COG0388 746697001988 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 746697001989 putative active site [active] 746697001990 catalytic triad [active] 746697001991 putative dimer interface [polypeptide binding]; other site 746697001992 RES domain; Region: RES; pfam08808 746697001993 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 746697001994 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 746697001995 deoxyhypusine synthase; Region: dhys; TIGR00321 746697001996 Deoxyhypusine synthase; Region: DS; cl00826 746697001997 Deoxyhypusine synthase; Region: DS; cl00826 746697001998 agmatinase; Region: agmatinase; TIGR01230 746697001999 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 746697002000 putative active site [active] 746697002001 Mn binding site [ion binding]; other site 746697002002 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 746697002003 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 746697002004 dimer interface [polypeptide binding]; other site 746697002005 active site 746697002006 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746697002007 catalytic residues [active] 746697002008 substrate binding site [chemical binding]; other site 746697002009 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 746697002010 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746697002011 RNA binding surface [nucleotide binding]; other site 746697002012 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 746697002013 active site 746697002014 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 746697002015 catalytic center binding site [active] 746697002016 ATP binding site [chemical binding]; other site 746697002017 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 746697002018 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 746697002019 Substrate-binding site [chemical binding]; other site 746697002020 Substrate specificity [chemical binding]; other site 746697002021 Protein of unknown function; Region: DUF3971; pfam13116 746697002022 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 746697002023 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 746697002024 GH3 auxin-responsive promoter; Region: GH3; pfam03321 746697002025 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 746697002026 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 746697002027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697002028 Walker A motif; other site 746697002029 ATP binding site [chemical binding]; other site 746697002030 Walker B motif; other site 746697002031 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 746697002032 Clp protease; Region: CLP_protease; pfam00574 746697002033 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 746697002034 oligomer interface [polypeptide binding]; other site 746697002035 active site residues [active] 746697002036 trigger factor; Region: tig; TIGR00115 746697002037 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 746697002038 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 746697002039 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 746697002040 catalytic triad [active] 746697002041 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 746697002042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697002043 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 746697002044 PGAP1-like protein; Region: PGAP1; pfam07819 746697002045 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 746697002046 active site 746697002047 hydrophilic channel; other site 746697002048 dimerization interface [polypeptide binding]; other site 746697002049 catalytic residues [active] 746697002050 active site lid [active] 746697002051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 746697002052 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911 746697002053 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 746697002054 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 746697002055 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 746697002056 catalytic residue [active] 746697002057 putative FPP diphosphate binding site; other site 746697002058 putative FPP binding hydrophobic cleft; other site 746697002059 dimer interface [polypeptide binding]; other site 746697002060 putative IPP diphosphate binding site; other site 746697002061 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 746697002062 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 746697002063 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 746697002064 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 746697002065 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697002066 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 746697002067 periplasmic chaperone; Provisional; Region: PRK10780 746697002068 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 746697002069 glutamate racemase; Provisional; Region: PRK00865 746697002070 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 746697002071 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 746697002072 trimer interface [polypeptide binding]; other site 746697002073 putative metal binding site [ion binding]; other site 746697002074 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697002075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697002076 active site 746697002077 phosphorylation site [posttranslational modification] 746697002078 intermolecular recognition site; other site 746697002079 dimerization interface [polypeptide binding]; other site 746697002080 LytTr DNA-binding domain; Region: LytTR; smart00850 746697002081 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 746697002083 binding surface 746697002084 TPR motif; other site 746697002085 Histidine kinase; Region: His_kinase; pfam06580 746697002086 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 746697002087 metal ion-dependent adhesion site (MIDAS); other site 746697002088 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 746697002089 CARDB; Region: CARDB; pfam07705 746697002090 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 746697002091 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 746697002092 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 746697002093 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 746697002094 Dodecin; Region: Dodecin; pfam07311 746697002095 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 746697002096 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 746697002097 catalytic residues [active] 746697002098 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 746697002099 active site 746697002100 zinc binding site [ion binding]; other site 746697002101 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697002102 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 746697002103 Glycoprotease family; Region: Peptidase_M22; pfam00814 746697002104 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 746697002105 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 746697002106 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697002107 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 746697002108 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 746697002109 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 746697002110 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697002111 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 746697002112 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746697002113 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 746697002114 FtsX-like permease family; Region: FtsX; pfam02687 746697002115 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746697002116 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 746697002117 FtsX-like permease family; Region: FtsX; pfam02687 746697002118 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746697002119 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746697002120 Walker A/P-loop; other site 746697002121 ATP binding site [chemical binding]; other site 746697002122 Q-loop/lid; other site 746697002123 ABC transporter signature motif; other site 746697002124 Walker B; other site 746697002125 D-loop; other site 746697002126 H-loop/switch region; other site 746697002127 Protein of unknown function (DUF420); Region: DUF420; pfam04238 746697002128 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 746697002129 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 746697002130 Cu(I) binding site [ion binding]; other site 746697002131 Family description; Region: VCBS; pfam13517 746697002132 Family description; Region: VCBS; pfam13517 746697002133 Family description; Region: VCBS; pfam13517 746697002134 Family description; Region: VCBS; pfam13517 746697002135 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697002137 non-specific DNA binding site [nucleotide binding]; other site 746697002138 salt bridge; other site 746697002139 sequence-specific DNA binding site [nucleotide binding]; other site 746697002140 Family description; Region: VCBS; pfam13517 746697002141 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002142 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 746697002143 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 746697002144 Subunit I/III interface [polypeptide binding]; other site 746697002145 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 746697002146 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 746697002147 Subunit I/III interface [polypeptide binding]; other site 746697002148 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 746697002149 UbiA prenyltransferase family; Region: UbiA; pfam01040 746697002150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 746697002151 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 746697002152 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 746697002153 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 746697002154 Predicted integral membrane protein [Function unknown]; Region: COG5652 746697002155 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 746697002156 lipoyl attachment site [posttranslational modification]; other site 746697002157 cell surface protein SprA; Region: surface_SprA; TIGR04189 746697002158 Motility related/secretion protein; Region: SprA_N; pfam14349 746697002159 Motility related/secretion protein; Region: SprA_N; pfam14349 746697002160 Motility related/secretion protein; Region: SprA_N; pfam14349 746697002161 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 746697002162 RuvA N terminal domain; Region: RuvA_N; pfam01330 746697002163 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 746697002164 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 746697002165 Malic enzyme, N-terminal domain; Region: malic; pfam00390 746697002166 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 746697002167 putative NAD(P) binding site [chemical binding]; other site 746697002168 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 746697002169 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 746697002170 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 746697002171 4Fe-4S binding domain; Region: Fer4; pfam00037 746697002172 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 746697002173 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 746697002174 Cytochrome P450; Region: p450; cl12078 746697002175 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 746697002176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697002177 Walker A motif; other site 746697002178 ATP binding site [chemical binding]; other site 746697002179 Walker B motif; other site 746697002180 arginine finger; other site 746697002181 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 746697002182 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 746697002183 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 746697002184 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 746697002185 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 746697002186 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 746697002187 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 746697002188 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 746697002189 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 746697002190 Uncharacterized conserved protein [Function unknown]; Region: COG3743 746697002191 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 746697002192 molybdopterin cofactor binding site; other site 746697002193 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 746697002194 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 746697002195 4Fe-4S binding domain; Region: Fer4; cl02805 746697002196 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 746697002197 Cytochrome c; Region: Cytochrom_C; pfam00034 746697002198 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 746697002199 heme-binding residues [chemical binding]; other site 746697002200 Sporulation related domain; Region: SPOR; cl10051 746697002201 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 746697002202 putative ligand binding site [chemical binding]; other site 746697002203 translation initiation factor IF-2; Region: IF-2; TIGR00487 746697002204 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 746697002205 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 746697002206 G1 box; other site 746697002207 putative GEF interaction site [polypeptide binding]; other site 746697002208 GTP/Mg2+ binding site [chemical binding]; other site 746697002209 Switch I region; other site 746697002210 G2 box; other site 746697002211 G3 box; other site 746697002212 Switch II region; other site 746697002213 G4 box; other site 746697002214 G5 box; other site 746697002215 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 746697002216 Translation-initiation factor 2; Region: IF-2; pfam11987 746697002217 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 746697002218 transcription termination factor NusA; Region: NusA; TIGR01953 746697002219 NusA N-terminal domain; Region: NusA_N; pfam08529 746697002220 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 746697002221 RNA binding site [nucleotide binding]; other site 746697002222 homodimer interface [polypeptide binding]; other site 746697002223 NusA-like KH domain; Region: KH_5; pfam13184 746697002224 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 746697002225 G-X-X-G motif; other site 746697002226 ribosome maturation protein RimP; Reviewed; Region: PRK00092 746697002227 Sm and related proteins; Region: Sm_like; cl00259 746697002228 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 746697002229 putative oligomer interface [polypeptide binding]; other site 746697002230 putative RNA binding site [nucleotide binding]; other site 746697002231 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697002232 Ligand Binding Site [chemical binding]; other site 746697002233 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697002234 Ligand Binding Site [chemical binding]; other site 746697002235 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 746697002236 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746697002237 acyl-activating enzyme (AAE) consensus motif; other site 746697002238 active site 746697002239 AMP binding site [chemical binding]; other site 746697002240 CoA binding site [chemical binding]; other site 746697002241 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 746697002242 active site 746697002243 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 746697002244 Cupin-like domain; Region: Cupin_8; pfam13621 746697002245 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 746697002246 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746697002247 Predicted exporter [General function prediction only]; Region: COG4258 746697002248 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 746697002249 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 746697002250 putative acyl-acceptor binding pocket; other site 746697002251 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 746697002252 Ligand binding site; other site 746697002253 Putative Catalytic site; other site 746697002254 DXD motif; other site 746697002255 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 746697002256 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 746697002257 active site 2 [active] 746697002258 dimer interface [polypeptide binding]; other site 746697002259 active site 1 [active] 746697002260 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 746697002261 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 746697002262 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 746697002263 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 746697002264 NodB motif; other site 746697002265 active site 746697002266 catalytic site [active] 746697002267 metal binding site [ion binding]; metal-binding site 746697002268 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 746697002269 active site 746697002270 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 746697002271 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 746697002272 dimer interface [polypeptide binding]; other site 746697002273 active site 746697002274 Phosphopantetheine attachment site; Region: PP-binding; cl09936 746697002275 Methyltransferase domain; Region: Methyltransf_18; pfam12847 746697002276 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 746697002277 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 746697002278 active site 746697002279 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 746697002280 active site 746697002281 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 746697002282 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 746697002283 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 746697002284 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 746697002285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697002286 Walker A/P-loop; other site 746697002287 ATP binding site [chemical binding]; other site 746697002288 Q-loop/lid; other site 746697002289 ABC transporter signature motif; other site 746697002290 Walker B; other site 746697002291 D-loop; other site 746697002292 H-loop/switch region; other site 746697002293 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 746697002294 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 746697002295 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 746697002296 active site 2 [active] 746697002297 active site 1 [active] 746697002298 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 746697002299 active site 2 [active] 746697002300 active site 1 [active] 746697002301 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 746697002302 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 746697002303 dimer interface [polypeptide binding]; other site 746697002304 active site 746697002305 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 746697002306 putative acyl-acceptor binding pocket; other site 746697002307 Phosphopantetheine attachment site; Region: PP-binding; cl09936 746697002308 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 746697002309 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 746697002310 dimer interface [polypeptide binding]; other site 746697002311 active site 746697002312 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 746697002313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 746697002314 NAD(P) binding site [chemical binding]; other site 746697002315 homotetramer interface [polypeptide binding]; other site 746697002316 homodimer interface [polypeptide binding]; other site 746697002317 active site 746697002318 KWG Leptospira; Region: KWG; pfam07656 746697002319 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 746697002320 active sites [active] 746697002321 tetramer interface [polypeptide binding]; other site 746697002322 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 746697002323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746697002324 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 746697002325 HicB family; Region: HicB; pfam05534 746697002326 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 746697002327 Predicted permeases [General function prediction only]; Region: COG0730 746697002328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002329 binding surface 746697002330 TPR motif; other site 746697002331 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 746697002332 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 746697002333 NodB motif; other site 746697002334 active site 746697002335 catalytic site [active] 746697002336 metal binding site [ion binding]; metal-binding site 746697002337 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746697002338 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697002339 catalytic residues [active] 746697002340 phosphodiesterase YaeI; Provisional; Region: PRK11340 746697002341 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 746697002342 putative active site [active] 746697002343 putative metal binding site [ion binding]; other site 746697002344 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697002346 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 746697002347 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 746697002348 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 746697002349 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 746697002350 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 746697002351 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 746697002352 active site 746697002353 dimer interface [polypeptide binding]; other site 746697002354 catalytic nucleophile [active] 746697002355 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 746697002356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697002357 putative substrate translocation pore; other site 746697002358 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697002359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697002360 active site 746697002361 phosphorylation site [posttranslational modification] 746697002362 intermolecular recognition site; other site 746697002363 dimerization interface [polypeptide binding]; other site 746697002364 LytTr DNA-binding domain; Region: LytTR; smart00850 746697002365 cyanophycin synthetase; Provisional; Region: PRK14016 746697002366 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697002367 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697002368 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697002369 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746697002370 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 746697002371 proposed catalytic triad [active] 746697002372 active site nucleophile [active] 746697002373 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 746697002374 catalytic nucleophile [active] 746697002375 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697002376 DNA polymerase I; Provisional; Region: PRK05755 746697002377 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 746697002378 active site 746697002379 metal binding site 1 [ion binding]; metal-binding site 746697002380 putative 5' ssDNA interaction site; other site 746697002381 metal binding site 3; metal-binding site 746697002382 metal binding site 2 [ion binding]; metal-binding site 746697002383 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 746697002384 putative DNA binding site [nucleotide binding]; other site 746697002385 putative metal binding site [ion binding]; other site 746697002386 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 746697002387 active site 746697002388 catalytic site [active] 746697002389 substrate binding site [chemical binding]; other site 746697002390 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 746697002391 active site 746697002392 DNA binding site [nucleotide binding] 746697002393 catalytic site [active] 746697002394 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 746697002395 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002396 pyruvate carboxylase; Reviewed; Region: PRK12999 746697002397 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746697002398 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697002399 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 746697002400 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 746697002401 active site 746697002402 catalytic residues [active] 746697002403 metal binding site [ion binding]; metal-binding site 746697002404 homodimer binding site [polypeptide binding]; other site 746697002405 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 746697002406 carboxyltransferase (CT) interaction site; other site 746697002407 biotinylation site [posttranslational modification]; other site 746697002408 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 746697002409 23S rRNA interface [nucleotide binding]; other site 746697002410 L3 interface [polypeptide binding]; other site 746697002411 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 746697002412 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 746697002413 rRNA interaction site [nucleotide binding]; other site 746697002414 S8 interaction site; other site 746697002415 putative laminin-1 binding site; other site 746697002416 elongation factor Ts; Provisional; Region: tsf; PRK09377 746697002417 UBA/TS-N domain; Region: UBA; pfam00627 746697002418 Elongation factor TS; Region: EF_TS; pfam00889 746697002419 Elongation factor TS; Region: EF_TS; pfam00889 746697002420 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002421 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002422 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 746697002423 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697002424 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 746697002425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002426 binding surface 746697002427 TPR motif; other site 746697002428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002429 binding surface 746697002430 TPR motif; other site 746697002431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002432 binding surface 746697002433 TPR motif; other site 746697002434 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 746697002435 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 746697002436 active site 746697002437 Substrate binding site; other site 746697002438 Mg++ binding site; other site 746697002439 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 746697002440 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 746697002441 trimer interface [polypeptide binding]; other site 746697002442 active site 746697002443 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 746697002444 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 746697002445 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 746697002446 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 746697002447 active site 746697002448 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 746697002449 MgtE intracellular N domain; Region: MgtE_N; smart00924 746697002450 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 746697002451 Divalent cation transporter; Region: MgtE; pfam01769 746697002452 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 746697002453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697002454 S-adenosylmethionine binding site [chemical binding]; other site 746697002455 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 746697002456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002457 binding surface 746697002458 TPR motif; other site 746697002459 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 746697002460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 746697002461 binding surface 746697002462 TPR motif; other site 746697002463 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002464 Protein of unknown function (DUF3109); Region: DUF3109; pfam11307 746697002465 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 746697002466 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 746697002467 C-terminal peptidase (prc); Region: prc; TIGR00225 746697002468 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 746697002469 protein binding site [polypeptide binding]; other site 746697002470 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 746697002471 Catalytic dyad [active] 746697002472 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 746697002473 catalytic motif [active] 746697002474 Zn binding site [ion binding]; other site 746697002475 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 746697002476 META domain; Region: META; cl01245 746697002477 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002478 Amino acid permease; Region: AA_permease_2; pfam13520 746697002479 Protein of unknown function (DUF3946); Region: DUF3946; pfam13102 746697002480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746697002481 active site 746697002482 DNA binding site [nucleotide binding] 746697002483 Int/Topo IB signature motif; other site 746697002484 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 746697002485 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 746697002486 putative active site [active] 746697002487 putative NTP binding site [chemical binding]; other site 746697002488 putative nucleic acid binding site [nucleotide binding]; other site 746697002489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697002490 non-specific DNA binding site [nucleotide binding]; other site 746697002491 salt bridge; other site 746697002492 sequence-specific DNA binding site [nucleotide binding]; other site 746697002493 HEPN domain; Region: HEPN; cl00824 746697002494 N-acetyltransferase; Region: Acetyltransf_2; cl00949 746697002495 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002496 Protein of unknown function, DUF488; Region: DUF488; pfam04343 746697002497 T5orf172 domain; Region: T5orf172; pfam10544 746697002498 DEAD-like helicases superfamily; Region: DEXDc; smart00487 746697002499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697002500 ATP binding site [chemical binding]; other site 746697002501 putative Mg++ binding site [ion binding]; other site 746697002502 Pseudomurein-binding repeat; Region: PMBR; pfam09373 746697002503 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746697002504 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 746697002505 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 746697002506 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 746697002507 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 746697002508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697002509 active site 746697002510 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 746697002511 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 746697002512 5S rRNA interface [nucleotide binding]; other site 746697002513 CTC domain interface [polypeptide binding]; other site 746697002514 L16 interface [polypeptide binding]; other site 746697002515 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 746697002516 putative active site [active] 746697002517 catalytic residue [active] 746697002518 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 746697002519 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 746697002520 active site 746697002521 Riboflavin kinase; Region: Flavokinase; pfam01687 746697002522 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 746697002523 seryl-tRNA synthetase; Provisional; Region: PRK05431 746697002524 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 746697002525 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 746697002526 dimer interface [polypeptide binding]; other site 746697002527 active site 746697002528 motif 1; other site 746697002529 motif 2; other site 746697002530 motif 3; other site 746697002531 Phosphate transporter family; Region: PHO4; pfam01384 746697002532 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697002533 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 746697002534 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697002535 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697002536 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 746697002537 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 746697002538 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 746697002539 PA/protease or protease-like domain interface [polypeptide binding]; other site 746697002540 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 746697002541 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 746697002542 Zn binding site [ion binding]; other site 746697002543 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002544 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 746697002545 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 746697002546 PA/protease or protease-like domain interface [polypeptide binding]; other site 746697002547 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 746697002548 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 746697002549 Zn binding site [ion binding]; other site 746697002550 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002551 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 746697002552 nucleoside/Zn binding site; other site 746697002553 dimer interface [polypeptide binding]; other site 746697002554 catalytic motif [active] 746697002555 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 746697002556 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 746697002557 TPP-binding site; other site 746697002558 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 746697002559 PYR/PP interface [polypeptide binding]; other site 746697002560 dimer interface [polypeptide binding]; other site 746697002561 TPP binding site [chemical binding]; other site 746697002562 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746697002563 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 746697002564 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 746697002565 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 746697002566 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 746697002567 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697002568 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002569 TPR motif; other site 746697002570 binding surface 746697002571 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697002572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697002573 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 746697002574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002575 binding surface 746697002576 TPR motif; other site 746697002577 CHAT domain; Region: CHAT; pfam12770 746697002578 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 746697002579 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 746697002580 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 746697002581 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 746697002582 active site 746697002583 metal binding site [ion binding]; metal-binding site 746697002584 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 746697002585 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 746697002586 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 746697002587 active site 746697002588 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746697002589 dimer interface [polypeptide binding]; other site 746697002590 substrate binding site [chemical binding]; other site 746697002591 catalytic residues [active] 746697002592 thymidine kinase; Provisional; Region: PRK04296 746697002593 DoxX-like family; Region: DoxX_2; pfam13564 746697002594 Predicted methyltransferases [General function prediction only]; Region: COG0313 746697002595 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 746697002596 putative SAM binding site [chemical binding]; other site 746697002597 putative homodimer interface [polypeptide binding]; other site 746697002598 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 746697002599 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002600 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002601 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002602 Transthyretin-like family; Region: DUF290; pfam01060 746697002603 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 746697002604 DHH family; Region: DHH; pfam01368 746697002605 DHHA1 domain; Region: DHHA1; pfam02272 746697002606 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 746697002607 putative active site [active] 746697002608 putative metal binding site [ion binding]; other site 746697002609 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 746697002610 active site 746697002611 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 746697002612 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 746697002613 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 746697002614 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 746697002615 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697002616 Ligand Binding Site [chemical binding]; other site 746697002617 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697002618 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 746697002619 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 746697002620 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697002621 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697002622 ligand binding site [chemical binding]; other site 746697002623 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 746697002624 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 746697002625 substrate-cofactor binding pocket; other site 746697002626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697002627 catalytic residue [active] 746697002628 Part of AAA domain; Region: AAA_19; pfam13245 746697002629 putative recombination protein RecB; Provisional; Region: PRK13909 746697002630 Family description; Region: UvrD_C_2; pfam13538 746697002631 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 746697002632 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 746697002633 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 746697002634 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 746697002635 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 746697002636 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 746697002637 active site 746697002638 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697002639 active site 746697002640 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 746697002641 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 746697002642 substrate binding site [chemical binding]; other site 746697002643 ATP binding site [chemical binding]; other site 746697002644 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 746697002645 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 746697002646 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 746697002647 active site 746697002648 RNA/DNA hybrid binding site [nucleotide binding]; other site 746697002649 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 746697002650 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 746697002651 active site 746697002652 substrate binding site [chemical binding]; other site 746697002653 cosubstrate binding site; other site 746697002654 catalytic site [active] 746697002655 acyl carrier protein; Provisional; Region: acpP; PRK00982 746697002656 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 746697002657 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 746697002658 dimer interface [polypeptide binding]; other site 746697002659 active site 746697002660 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 746697002661 dimerization interface [polypeptide binding]; other site 746697002662 active site 746697002663 metal binding site [ion binding]; metal-binding site 746697002664 Double-stranded RNA binding motif; Region: dsrm; pfam00035 746697002665 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 746697002666 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 746697002667 domain interfaces; other site 746697002668 active site 746697002669 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 746697002670 active site 746697002671 DNA polymerase IV; Validated; Region: PRK02406 746697002672 DNA binding site [nucleotide binding] 746697002673 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 746697002674 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 746697002675 NAD binding site [chemical binding]; other site 746697002676 active site 746697002677 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 746697002678 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 746697002679 putative active site [active] 746697002680 putative metal binding residues [ion binding]; other site 746697002681 signature motif; other site 746697002682 putative dimer interface [polypeptide binding]; other site 746697002683 putative phosphate binding site [ion binding]; other site 746697002684 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 746697002685 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 746697002686 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 746697002687 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 746697002688 active site 746697002689 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 746697002690 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 746697002691 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 746697002692 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 746697002693 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 746697002694 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 746697002695 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 746697002696 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 746697002697 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 746697002698 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 746697002699 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 746697002700 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697002701 Predicted transcriptional regulators [Transcription]; Region: COG1510 746697002702 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002703 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002704 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002705 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002706 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002707 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002708 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 746697002709 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697002710 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 746697002711 Transglycosylase; Region: Transgly; pfam00912 746697002712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 746697002713 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 746697002714 Bacterial Ig-like domain; Region: Big_5; pfam13205 746697002715 MG2 domain; Region: A2M_N; pfam01835 746697002716 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 746697002717 Alpha-2-macroglobulin family; Region: A2M; pfam00207 746697002718 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 746697002719 surface patch; other site 746697002720 thioester region; other site 746697002721 specificity defining residues; other site 746697002722 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 746697002723 catalytic nucleophile [active] 746697002724 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 746697002725 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 746697002726 aldehyde dehydrogenase family 7 member; Region: PLN02315 746697002727 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 746697002728 tetrameric interface [polypeptide binding]; other site 746697002729 NAD binding site [chemical binding]; other site 746697002730 catalytic residues [active] 746697002731 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 746697002732 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 746697002733 homodimer interface [polypeptide binding]; other site 746697002734 putative substrate binding pocket [chemical binding]; other site 746697002735 diiron center [ion binding]; other site 746697002736 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 746697002737 active site 746697002738 metal binding site [ion binding]; metal-binding site 746697002739 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 746697002740 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 746697002741 Divergent AAA domain; Region: AAA_4; pfam04326 746697002742 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 746697002743 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 746697002744 putative NAD(P) binding site [chemical binding]; other site 746697002745 homotetramer interface [polypeptide binding]; other site 746697002746 homodimer interface [polypeptide binding]; other site 746697002747 active site 746697002748 MoxR-like ATPases [General function prediction only]; Region: COG0714 746697002749 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697002750 Walker A motif; other site 746697002751 ATP binding site [chemical binding]; other site 746697002752 Walker B motif; other site 746697002753 arginine finger; other site 746697002754 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 746697002755 Protein of unknown function DUF58; Region: DUF58; pfam01882 746697002756 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 746697002757 metal ion-dependent adhesion site (MIDAS); other site 746697002758 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 746697002759 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 746697002760 metal ion-dependent adhesion site (MIDAS); other site 746697002761 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 746697002762 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 746697002763 metal ion-dependent adhesion site (MIDAS); other site 746697002764 Tetratricopeptide repeat; Region: TPR_16; pfam13432 746697002765 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002766 TPR motif; other site 746697002767 TPR repeat; Region: TPR_11; pfam13414 746697002768 binding surface 746697002769 Oxygen tolerance; Region: BatD; pfam13584 746697002770 TPR repeat; Region: TPR_11; pfam13414 746697002771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697002772 binding surface 746697002773 TPR motif; other site 746697002774 Bacterial SH3 domain homologues; Region: SH3b; smart00287 746697002775 Colicin V production protein; Region: Colicin_V; pfam02674 746697002776 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 746697002777 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 746697002778 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 746697002779 dimer interface [polypeptide binding]; other site 746697002780 motif 1; other site 746697002781 active site 746697002782 motif 2; other site 746697002783 motif 3; other site 746697002784 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 746697002785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697002786 Walker A/P-loop; other site 746697002787 ATP binding site [chemical binding]; other site 746697002788 Q-loop/lid; other site 746697002789 ABC transporter signature motif; other site 746697002790 Walker B; other site 746697002791 D-loop; other site 746697002792 H-loop/switch region; other site 746697002793 Prostaglandin dehydrogenases; Region: PGDH; cd05288 746697002794 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 746697002795 NAD(P) binding site [chemical binding]; other site 746697002796 substrate binding site [chemical binding]; other site 746697002797 dimer interface [polypeptide binding]; other site 746697002798 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 746697002799 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 746697002800 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 746697002801 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 746697002802 Transglycosylase; Region: Transgly; cl17702 746697002803 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 746697002804 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 746697002805 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 746697002806 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746697002807 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 746697002808 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 746697002809 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 746697002810 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 746697002811 carboxyltransferase (CT) interaction site; other site 746697002812 biotinylation site [posttranslational modification]; other site 746697002813 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 746697002814 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 746697002815 dimer interface [polypeptide binding]; other site 746697002816 active site 746697002817 CoA binding pocket [chemical binding]; other site 746697002818 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 746697002819 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 746697002820 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 746697002821 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 746697002822 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 746697002823 Lumazine binding domain; Region: Lum_binding; pfam00677 746697002824 Lumazine binding domain; Region: Lum_binding; pfam00677 746697002825 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697002826 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 746697002827 dimer interface [polypeptide binding]; other site 746697002828 substrate binding site [chemical binding]; other site 746697002829 metal binding site [ion binding]; metal-binding site 746697002830 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 746697002831 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697002832 metal binding site [ion binding]; metal-binding site 746697002833 Acyltransferase family; Region: Acyl_transf_3; pfam01757 746697002834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697002835 FOG: CBS domain [General function prediction only]; Region: COG0517 746697002836 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629 746697002837 Ferritin-like domain; Region: Ferritin_2; pfam13668 746697002838 Ferritin-like domain; Region: Ferritin_2; pfam13668 746697002839 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 746697002840 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 746697002841 dimer interface [polypeptide binding]; other site 746697002842 ssDNA binding site [nucleotide binding]; other site 746697002843 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746697002844 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 746697002845 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697002846 ATP binding site [chemical binding]; other site 746697002847 putative Mg++ binding site [ion binding]; other site 746697002848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697002849 nucleotide binding region [chemical binding]; other site 746697002850 ATP-binding site [chemical binding]; other site 746697002851 RQC domain; Region: RQC; pfam09382 746697002852 HRDC domain; Region: HRDC; pfam00570 746697002853 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 746697002854 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 746697002855 putative active site [active] 746697002856 Zn binding site [ion binding]; other site 746697002857 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 746697002858 EamA-like transporter family; Region: EamA; pfam00892 746697002859 EamA-like transporter family; Region: EamA; cl17759 746697002860 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 746697002861 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 746697002862 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 746697002863 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 746697002864 RNA binding site [nucleotide binding]; other site 746697002865 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 746697002866 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 746697002867 active site 746697002868 HIGH motif; other site 746697002869 KMSKS motif; other site 746697002870 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 746697002871 tRNA binding surface [nucleotide binding]; other site 746697002872 anticodon binding site; other site 746697002873 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 746697002874 dimer interface [polypeptide binding]; other site 746697002875 putative tRNA-binding site [nucleotide binding]; other site 746697002876 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 746697002877 dimer interface [polypeptide binding]; other site 746697002878 catalytic triad [active] 746697002879 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 746697002880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746697002881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697002882 non-specific DNA binding site [nucleotide binding]; other site 746697002883 salt bridge; other site 746697002884 sequence-specific DNA binding site [nucleotide binding]; other site 746697002885 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 746697002886 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 746697002887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697002888 ATP binding site [chemical binding]; other site 746697002889 putative Mg++ binding site [ion binding]; other site 746697002890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697002891 nucleotide binding region [chemical binding]; other site 746697002892 ATP-binding site [chemical binding]; other site 746697002893 TRCF domain; Region: TRCF; pfam03461 746697002894 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 746697002895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746697002896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697002897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746697002898 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 746697002899 putative active site [active] 746697002900 putative metal binding site [ion binding]; other site 746697002901 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 746697002902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 746697002903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697002904 ATP binding site [chemical binding]; other site 746697002905 putative Mg++ binding site [ion binding]; other site 746697002906 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697002907 nucleotide binding region [chemical binding]; other site 746697002908 ATP-binding site [chemical binding]; other site 746697002909 DEAD/H associated; Region: DEAD_assoc; pfam08494 746697002910 ATP-dependent DNA ligase; Validated; Region: PRK09247 746697002911 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 746697002912 active site 746697002913 DNA binding site [nucleotide binding] 746697002914 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 746697002915 DNA binding site [nucleotide binding] 746697002916 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 746697002917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 746697002918 tellurium resistance terB-like protein; Region: terB_like; cd07177 746697002919 metal binding site [ion binding]; metal-binding site 746697002920 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 746697002921 AMP binding site [chemical binding]; other site 746697002922 metal binding site [ion binding]; metal-binding site 746697002923 active site 746697002924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 746697002925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697002926 Coenzyme A binding pocket [chemical binding]; other site 746697002927 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 746697002928 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 746697002929 nucleotide binding site [chemical binding]; other site 746697002930 substrate binding site [chemical binding]; other site 746697002931 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 746697002932 putative acyl-acceptor binding pocket; other site 746697002933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 746697002934 Predicted membrane protein [Function unknown]; Region: COG2259 746697002935 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 746697002936 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697002937 TM2 domain; Region: TM2; pfam05154 746697002938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 746697002939 active site 746697002940 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 746697002941 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179 746697002942 putative ligand binding site [chemical binding]; other site 746697002943 putative NAD binding site [chemical binding]; other site 746697002944 catalytic site [active] 746697002945 Cupin domain; Region: Cupin_2; cl17218 746697002946 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 746697002947 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 746697002948 core domain interface [polypeptide binding]; other site 746697002949 delta subunit interface [polypeptide binding]; other site 746697002950 epsilon subunit interface [polypeptide binding]; other site 746697002951 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 746697002952 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 746697002953 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 746697002954 beta subunit interaction interface [polypeptide binding]; other site 746697002955 Walker A motif; other site 746697002956 ATP binding site [chemical binding]; other site 746697002957 Walker B motif; other site 746697002958 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 746697002959 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 746697002960 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 746697002961 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 746697002962 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 746697002963 ATP synthase A chain; Region: ATP-synt_A; cl00413 746697002964 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 746697002965 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 746697002966 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 746697002967 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 746697002968 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 746697002969 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 746697002970 FAD binding pocket [chemical binding]; other site 746697002971 FAD binding motif [chemical binding]; other site 746697002972 phosphate binding motif [ion binding]; other site 746697002973 beta-alpha-beta structure motif; other site 746697002974 NAD(p) ribose binding residues [chemical binding]; other site 746697002975 NAD binding pocket [chemical binding]; other site 746697002976 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 746697002977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 746697002978 catalytic loop [active] 746697002979 iron binding site [ion binding]; other site 746697002980 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 746697002981 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 746697002982 putative active site [active] 746697002983 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 746697002984 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 746697002985 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; pfam02086 746697002986 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 746697002987 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 746697002988 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 746697002989 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 746697002990 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 746697002991 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746697002992 active site 746697002993 CoA binding site [chemical binding]; other site 746697002994 AMP binding site [chemical binding]; other site 746697002995 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697002996 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 746697002997 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 746697002998 Bacterial sugar transferase; Region: Bac_transf; pfam02397 746697002999 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 746697003000 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 746697003001 NAD binding site [chemical binding]; other site 746697003002 putative substrate binding site 2 [chemical binding]; other site 746697003003 putative substrate binding site 1 [chemical binding]; other site 746697003004 active site 746697003005 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 746697003006 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 746697003007 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 746697003008 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 746697003009 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 746697003010 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 746697003011 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 746697003012 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 746697003013 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 746697003014 putative NAD(P) binding site [chemical binding]; other site 746697003015 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 746697003016 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746697003017 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 746697003018 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746697003019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697003020 S-adenosylmethionine binding site [chemical binding]; other site 746697003021 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 746697003022 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 746697003023 active site 746697003024 dimer interface [polypeptide binding]; other site 746697003025 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 746697003026 Ligand Binding Site [chemical binding]; other site 746697003027 Molecular Tunnel; other site 746697003028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697003029 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 746697003030 O-Antigen ligase; Region: Wzy_C; pfam04932 746697003031 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 746697003032 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 746697003033 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 746697003034 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 746697003035 NAD(P) binding pocket [chemical binding]; other site 746697003036 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 746697003037 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 746697003038 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 746697003039 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 746697003040 active site 746697003041 homodimer interface [polypeptide binding]; other site 746697003042 GH3 auxin-responsive promoter; Region: GH3; pfam03321 746697003043 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 746697003044 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697003045 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 746697003046 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 746697003047 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 746697003048 N-acetyl-D-glucosamine binding site [chemical binding]; other site 746697003049 catalytic residue [active] 746697003050 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697003051 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697003052 Phosphoglycerate kinase; Region: PGK; pfam00162 746697003053 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 746697003054 substrate binding site [chemical binding]; other site 746697003055 hinge regions; other site 746697003056 ADP binding site [chemical binding]; other site 746697003057 catalytic site [active] 746697003058 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 746697003059 DNA polymerase III subunit delta'; Validated; Region: PRK08485 746697003060 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 746697003061 Methyltransferase domain; Region: Methyltransf_23; pfam13489 746697003062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697003063 S-adenosylmethionine binding site [chemical binding]; other site 746697003064 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 746697003065 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 746697003066 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 746697003067 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 746697003068 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 746697003069 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 746697003070 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 746697003071 HIGH motif; other site 746697003072 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 746697003073 active site 746697003074 KMSKS motif; other site 746697003075 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 746697003076 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 746697003077 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 746697003078 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003079 active site 746697003080 HIGH motif; other site 746697003081 nucleotide binding site [chemical binding]; other site 746697003082 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003083 active site 746697003084 KMSKS motif; other site 746697003085 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 746697003086 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 746697003087 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 746697003088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697003089 sequence-specific DNA binding site [nucleotide binding]; other site 746697003090 salt bridge; other site 746697003091 Dihydroneopterin aldolase; Region: FolB; smart00905 746697003092 active site 746697003093 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 746697003094 ribonuclease R; Region: RNase_R; TIGR02063 746697003095 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746697003096 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746697003097 RNB domain; Region: RNB; pfam00773 746697003098 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 746697003099 RNA binding site [nucleotide binding]; other site 746697003100 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 746697003101 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 746697003102 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 746697003103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697003104 Coenzyme A binding pocket [chemical binding]; other site 746697003105 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 746697003106 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 746697003107 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 746697003108 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 746697003109 protein binding site [polypeptide binding]; other site 746697003110 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 746697003111 Catalytic dyad [active] 746697003112 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 746697003113 ribonuclease P; Reviewed; Region: rnpA; PRK01903 746697003114 Transposase IS200 like; Region: Y1_Tnp; cl00848 746697003115 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 746697003116 Zn binding site [ion binding]; other site 746697003117 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 746697003118 Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483 746697003119 active site 746697003120 catalytic triad [active] 746697003121 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 746697003122 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 746697003123 TrkA-N domain; Region: TrkA_N; pfam02254 746697003124 GTP-binding protein LepA; Provisional; Region: PRK05433 746697003125 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 746697003126 G1 box; other site 746697003127 putative GEF interaction site [polypeptide binding]; other site 746697003128 GTP/Mg2+ binding site [chemical binding]; other site 746697003129 Switch I region; other site 746697003130 G2 box; other site 746697003131 G3 box; other site 746697003132 Switch II region; other site 746697003133 G4 box; other site 746697003134 G5 box; other site 746697003135 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 746697003136 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 746697003137 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 746697003138 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 746697003139 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 746697003140 FMN binding site [chemical binding]; other site 746697003141 active site 746697003142 catalytic residues [active] 746697003143 substrate binding site [chemical binding]; other site 746697003144 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 746697003145 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 746697003146 FAD binding pocket [chemical binding]; other site 746697003147 conserved FAD binding motif [chemical binding]; other site 746697003148 phosphate binding motif [ion binding]; other site 746697003149 beta-alpha-beta structure motif; other site 746697003150 NAD binding pocket [chemical binding]; other site 746697003151 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 746697003152 FtsX-like permease family; Region: FtsX; pfam02687 746697003153 Ribosome-binding factor A; Region: RBFA; pfam02033 746697003154 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 746697003155 NADH(P)-binding; Region: NAD_binding_10; pfam13460 746697003156 putative NAD(P) binding site [chemical binding]; other site 746697003157 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 746697003158 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 746697003159 active site 746697003160 Zn binding site [ion binding]; other site 746697003161 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 746697003162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697003163 NAD(P) binding site [chemical binding]; other site 746697003164 active site 746697003165 SdiA-regulated; Region: SdiA-regulated; cd09971 746697003166 putative active site [active] 746697003167 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 746697003168 GIY-YIG motif/motif A; other site 746697003169 putative active site [active] 746697003170 putative metal binding site [ion binding]; other site 746697003171 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 746697003172 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 746697003173 Class I ribonucleotide reductase; Region: RNR_I; cd01679 746697003174 active site 746697003175 dimer interface [polypeptide binding]; other site 746697003176 catalytic residues [active] 746697003177 effector binding site; other site 746697003178 R2 peptide binding site; other site 746697003179 ATP cone domain; Region: ATP-cone; pfam03477 746697003180 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 746697003181 dimer interface [polypeptide binding]; other site 746697003182 putative radical transfer pathway; other site 746697003183 diiron center [ion binding]; other site 746697003184 tyrosyl radical; other site 746697003185 DNA topoisomerase type I; Provisional; Region: PHA03101 746697003186 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 746697003187 active site 746697003188 DNA binding site [nucleotide binding] 746697003189 Int/Topo IB signature motif; other site 746697003190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697003191 binding surface 746697003192 TPR motif; other site 746697003193 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 746697003194 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697003195 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697003196 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 746697003197 RIP metalloprotease RseP; Region: TIGR00054 746697003198 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 746697003199 active site 746697003200 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 746697003201 protein binding site [polypeptide binding]; other site 746697003202 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 746697003203 putative substrate binding region [chemical binding]; other site 746697003204 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 746697003205 Peptidase family M1; Region: Peptidase_M1; pfam01433 746697003206 Zn binding site [ion binding]; other site 746697003207 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003208 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 746697003209 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 746697003210 Cu(I) binding site [ion binding]; other site 746697003211 FeoA domain; Region: FeoA; pfam04023 746697003212 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 746697003213 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 746697003214 G1 box; other site 746697003215 GTP/Mg2+ binding site [chemical binding]; other site 746697003216 Switch I region; other site 746697003217 G2 box; other site 746697003218 G3 box; other site 746697003219 Switch II region; other site 746697003220 G4 box; other site 746697003221 G5 box; other site 746697003222 Nucleoside recognition; Region: Gate; pfam07670 746697003223 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 746697003224 Nucleoside recognition; Region: Gate; pfam07670 746697003225 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 746697003226 manganese transport protein MntH; Reviewed; Region: PRK00701 746697003227 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 746697003228 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 746697003229 Ligand Binding Site [chemical binding]; other site 746697003230 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 746697003231 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 746697003232 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 746697003233 FeoA domain; Region: FeoA; pfam04023 746697003234 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697003235 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 746697003236 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 746697003237 N-terminal plug; other site 746697003238 ligand-binding site [chemical binding]; other site 746697003239 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 746697003240 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 746697003241 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 746697003242 putative metal binding site [ion binding]; other site 746697003243 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 746697003244 HSP70 interaction site [polypeptide binding]; other site 746697003245 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 746697003246 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 746697003247 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 746697003248 putative acyl-acceptor binding pocket; other site 746697003249 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 746697003250 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697003251 Zn2+ binding site [ion binding]; other site 746697003252 Mg2+ binding site [ion binding]; other site 746697003253 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 746697003254 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 746697003255 Cl- selectivity filter; other site 746697003256 Cl- binding residues [ion binding]; other site 746697003257 pore gating glutamate residue; other site 746697003258 dimer interface [polypeptide binding]; other site 746697003259 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 746697003260 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 746697003261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697003262 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697003263 Helix-turn-helix domain; Region: HTH_18; pfam12833 746697003264 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 746697003265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697003266 FeS/SAM binding site; other site 746697003267 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 746697003268 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 746697003269 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697003270 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 746697003271 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 746697003272 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 746697003273 substrate binding site [chemical binding]; other site 746697003274 oxyanion hole (OAH) forming residues; other site 746697003275 trimer interface [polypeptide binding]; other site 746697003276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 746697003277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697003278 dimer interface [polypeptide binding]; other site 746697003279 phosphorylation site [posttranslational modification] 746697003280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697003281 ATP binding site [chemical binding]; other site 746697003282 Mg2+ binding site [ion binding]; other site 746697003283 G-X-G motif; other site 746697003284 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 746697003285 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003286 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 746697003287 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 746697003288 ferrochelatase; Reviewed; Region: hemH; PRK00035 746697003289 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 746697003290 C-terminal domain interface [polypeptide binding]; other site 746697003291 active site 746697003292 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 746697003293 active site 746697003294 N-terminal domain interface [polypeptide binding]; other site 746697003295 Protein of unknown function DUF86; Region: DUF86; cl01031 746697003296 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 746697003297 active site 746697003298 NTP binding site [chemical binding]; other site 746697003299 metal binding triad [ion binding]; metal-binding site 746697003300 antibiotic binding site [chemical binding]; other site 746697003301 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697003302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697003303 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 746697003304 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 746697003305 tRNA; other site 746697003306 putative tRNA binding site [nucleotide binding]; other site 746697003307 putative NADP binding site [chemical binding]; other site 746697003308 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 746697003309 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 746697003310 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 746697003311 domain interfaces; other site 746697003312 active site 746697003313 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 746697003314 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 746697003315 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 746697003316 TrkA-N domain; Region: TrkA_N; pfam02254 746697003317 TrkA-C domain; Region: TrkA_C; pfam02080 746697003318 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 746697003319 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 746697003320 active site 746697003321 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 746697003322 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 746697003323 substrate binding site [chemical binding]; other site 746697003324 active site 746697003325 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 746697003326 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 746697003327 DEAD-like helicases superfamily; Region: DEXDc; smart00487 746697003328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697003329 ATP binding site [chemical binding]; other site 746697003330 putative Mg++ binding site [ion binding]; other site 746697003331 helicase superfamily c-terminal domain; Region: HELICc; smart00490 746697003332 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 746697003333 dimer interface [polypeptide binding]; other site 746697003334 allosteric magnesium binding site [ion binding]; other site 746697003335 active site 746697003336 aspartate-rich active site metal binding site; other site 746697003337 Schiff base residues; other site 746697003338 Domain of unknown function DUF21; Region: DUF21; pfam01595 746697003339 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 746697003340 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 746697003341 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 746697003342 DNA binding site [nucleotide binding] 746697003343 active site 746697003344 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 746697003345 active site 746697003346 catalytic site [active] 746697003347 substrate binding site [chemical binding]; other site 746697003348 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 746697003349 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 746697003350 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 746697003351 active site 746697003352 Zn binding site [ion binding]; other site 746697003353 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 746697003354 Interdomain contacts; other site 746697003355 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003356 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 746697003357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746697003358 Walker A/P-loop; other site 746697003359 ATP binding site [chemical binding]; other site 746697003360 Q-loop/lid; other site 746697003361 ABC transporter signature motif; other site 746697003362 Walker B; other site 746697003363 D-loop; other site 746697003364 H-loop/switch region; other site 746697003365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746697003366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 746697003367 Walker A/P-loop; other site 746697003368 ATP binding site [chemical binding]; other site 746697003369 Q-loop/lid; other site 746697003370 ABC transporter signature motif; other site 746697003371 Walker B; other site 746697003372 D-loop; other site 746697003373 H-loop/switch region; other site 746697003374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 746697003375 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 746697003376 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 746697003377 Transglycosylase; Region: Transgly; pfam00912 746697003378 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 746697003379 GldH lipoprotein; Region: GldH_lipo; pfam14109 746697003380 PSP1 C-terminal conserved region; Region: PSP1; cl00770 746697003381 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 746697003382 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 746697003383 active site residue [active] 746697003384 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003385 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 746697003386 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 746697003387 hexamer interface [polypeptide binding]; other site 746697003388 Walker A motif; other site 746697003389 ATP binding site [chemical binding]; other site 746697003390 Walker B motif; other site 746697003391 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697003392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697003393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697003394 DNA binding residues [nucleotide binding] 746697003395 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697003396 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 746697003397 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 746697003398 putative acyl-acceptor binding pocket; other site 746697003399 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 746697003400 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 746697003401 active site 746697003402 HIGH motif; other site 746697003403 dimer interface [polypeptide binding]; other site 746697003404 KMSKS motif; other site 746697003405 DNA protecting protein DprA; Region: dprA; TIGR00732 746697003406 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 746697003407 Sporulation related domain; Region: SPOR; pfam05036 746697003408 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 746697003409 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 746697003410 active site 746697003411 catalytic triad [active] 746697003412 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 746697003413 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003414 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 746697003415 active site 746697003416 catalytic triad [active] 746697003417 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 746697003418 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003419 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 746697003420 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 746697003421 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 746697003422 Uncharacterized conserved protein [Function unknown]; Region: COG3743 746697003423 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 746697003424 gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512 746697003425 Domain of unknown function DUF21; Region: DUF21; pfam01595 746697003426 gliding motility-associated protein GldE; Region: GldE; TIGR03520 746697003427 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 746697003428 Transporter associated domain; Region: CorC_HlyC; smart01091 746697003429 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 746697003430 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 746697003431 dimer interface [polypeptide binding]; other site 746697003432 ssDNA binding site [nucleotide binding]; other site 746697003433 tetramer (dimer of dimers) interface [polypeptide binding]; other site 746697003434 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 746697003435 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 746697003436 minor groove reading motif; other site 746697003437 helix-hairpin-helix signature motif; other site 746697003438 substrate binding pocket [chemical binding]; other site 746697003439 active site 746697003440 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 746697003441 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 746697003442 DNA binding and oxoG recognition site [nucleotide binding] 746697003443 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 746697003444 IHF - DNA interface [nucleotide binding]; other site 746697003445 IHF dimer interface [polypeptide binding]; other site 746697003446 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 746697003447 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 746697003448 homodimer interface [polypeptide binding]; other site 746697003449 oligonucleotide binding site [chemical binding]; other site 746697003450 RecX family; Region: RecX; pfam02631 746697003451 Cupin-like domain; Region: Cupin_8; pfam13621 746697003452 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 746697003453 gamma subunit interface [polypeptide binding]; other site 746697003454 LBP interface [polypeptide binding]; other site 746697003455 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 746697003456 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 746697003457 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 746697003458 alpha subunit interaction interface [polypeptide binding]; other site 746697003459 Walker A motif; other site 746697003460 ATP binding site [chemical binding]; other site 746697003461 Walker B motif; other site 746697003462 inhibitor binding site; inhibition site 746697003463 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 746697003464 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 746697003465 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 746697003466 homodimer interface [polypeptide binding]; other site 746697003467 substrate-cofactor binding pocket; other site 746697003468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697003469 catalytic residue [active] 746697003470 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 746697003471 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 746697003472 glutaminase active site [active] 746697003473 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 746697003474 dimer interface [polypeptide binding]; other site 746697003475 active site 746697003476 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 746697003477 dimer interface [polypeptide binding]; other site 746697003478 active site 746697003479 Domain of unknown function (DUF4270); Region: DUF4270; pfam14092 746697003480 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 746697003481 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 746697003482 pantoate--beta-alanine ligase; Region: panC; TIGR00018 746697003483 active site 746697003484 nucleotide binding site [chemical binding]; other site 746697003485 HIGH motif; other site 746697003486 KMSKS motif; other site 746697003487 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 746697003488 tetramerization interface [polypeptide binding]; other site 746697003489 active site 746697003490 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 746697003491 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 746697003492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697003493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697003494 active site 746697003495 phosphorylation site [posttranslational modification] 746697003496 intermolecular recognition site; other site 746697003497 dimerization interface [polypeptide binding]; other site 746697003498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697003499 DNA binding residues [nucleotide binding] 746697003500 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 746697003501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697003502 Histidine kinase; Region: HisKA_3; pfam07730 746697003503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697003504 ATP binding site [chemical binding]; other site 746697003505 Mg2+ binding site [ion binding]; other site 746697003506 G-X-G motif; other site 746697003507 DNA repair protein RadA; Provisional; Region: PRK11823 746697003508 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 746697003509 Walker A motif/ATP binding site; other site 746697003510 ATP binding site [chemical binding]; other site 746697003511 Walker B motif; other site 746697003512 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 746697003513 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 746697003514 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697003515 acyl-coenzyme A oxidase; Region: PLN02526 746697003516 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 746697003517 active site 746697003518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746697003519 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746697003520 active site 746697003521 catalytic tetrad [active] 746697003522 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 746697003523 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 746697003524 putative active site [active] 746697003525 putative catalytic site [active] 746697003526 putative DNA binding site [nucleotide binding]; other site 746697003527 putative phosphate binding site [ion binding]; other site 746697003528 metal binding site A [ion binding]; metal-binding site 746697003529 putative AP binding site [nucleotide binding]; other site 746697003530 putative metal binding site B [ion binding]; other site 746697003531 cell surface protein SprA; Region: surface_SprA; TIGR04189 746697003532 glycyl-tRNA synthetase; Provisional; Region: PRK04173 746697003533 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 746697003534 motif 1; other site 746697003535 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 746697003536 active site 746697003537 motif 2; other site 746697003538 motif 3; other site 746697003539 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 746697003540 anticodon binding site; other site 746697003541 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 746697003542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697003543 active site 746697003544 Bacterial Ig-like domain; Region: Big_5; pfam13205 746697003545 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 746697003546 putative active site [active] 746697003547 catalytic triad [active] 746697003548 dimer interface [polypeptide binding]; other site 746697003549 multimer interface [polypeptide binding]; other site 746697003550 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 746697003551 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 746697003552 dimer interface [polypeptide binding]; other site 746697003553 active site 746697003554 heme binding site [chemical binding]; other site 746697003555 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 746697003556 methionine aminotransferase; Validated; Region: PRK09082 746697003557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746697003558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697003559 homodimer interface [polypeptide binding]; other site 746697003560 catalytic residue [active] 746697003561 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 746697003562 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 746697003563 homotetramer interface [polypeptide binding]; other site 746697003564 ligand binding site [chemical binding]; other site 746697003565 catalytic site [active] 746697003566 NAD binding site [chemical binding]; other site 746697003567 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 746697003568 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 746697003569 PcrB family; Region: PcrB; pfam01884 746697003570 geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169 746697003571 phosphate binding site [ion binding]; other site 746697003572 Domain of unknown function DUF77; Region: DUF77; cl00307 746697003573 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 746697003574 AAA domain; Region: AAA_28; pfam13521 746697003575 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 746697003576 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 746697003577 hypothetical protein; Provisional; Region: PRK09256 746697003578 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 746697003579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697003580 active site 746697003581 phosphorylation site [posttranslational modification] 746697003582 intermolecular recognition site; other site 746697003583 dimerization interface [polypeptide binding]; other site 746697003584 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697003585 Walker A motif; other site 746697003586 ATP binding site [chemical binding]; other site 746697003587 Walker B motif; other site 746697003588 arginine finger; other site 746697003589 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 746697003590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697003591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697003592 dimer interface [polypeptide binding]; other site 746697003593 phosphorylation site [posttranslational modification] 746697003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697003595 ATP binding site [chemical binding]; other site 746697003596 Mg2+ binding site [ion binding]; other site 746697003597 G-X-G motif; other site 746697003598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697003599 Response regulator receiver domain; Region: Response_reg; pfam00072 746697003600 active site 746697003601 phosphorylation site [posttranslational modification] 746697003602 intermolecular recognition site; other site 746697003603 dimerization interface [polypeptide binding]; other site 746697003604 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697003605 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697003606 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 746697003607 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 746697003608 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 746697003609 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 746697003610 nucleotide binding site/active site [active] 746697003611 HIT family signature motif; other site 746697003612 catalytic residue [active] 746697003613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697003614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697003615 phosphorylation site [posttranslational modification] 746697003616 dimer interface [polypeptide binding]; other site 746697003617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697003618 ATP binding site [chemical binding]; other site 746697003619 Mg2+ binding site [ion binding]; other site 746697003620 G-X-G motif; other site 746697003621 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 746697003622 Domain of unknown function (DUF3127); Region: DUF3127; pfam11325 746697003623 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 746697003624 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 746697003625 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 746697003626 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003627 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 746697003628 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 746697003629 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 746697003630 RNA binding site [nucleotide binding]; other site 746697003631 active site 746697003632 Protein of unknown function DUF86; Region: DUF86; cl01031 746697003633 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 746697003634 active site 746697003635 NTP binding site [chemical binding]; other site 746697003636 metal binding triad [ion binding]; metal-binding site 746697003637 antibiotic binding site [chemical binding]; other site 746697003638 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 746697003639 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 746697003640 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 746697003641 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 746697003642 FtsX-like permease family; Region: FtsX; pfam02687 746697003643 UbiA prenyltransferase family; Region: UbiA; pfam01040 746697003644 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 746697003645 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003646 active site 746697003647 HIGH motif; other site 746697003648 nucleotide binding site [chemical binding]; other site 746697003649 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 746697003650 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003651 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003652 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003653 active site 746697003654 KMSKS motif; other site 746697003655 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 746697003656 tRNA binding surface [nucleotide binding]; other site 746697003657 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 746697003658 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 746697003659 Outer membrane protein Omp28; Region: Omp28; pfam11551 746697003660 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003661 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746697003662 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 746697003663 Protein of unknown function (DUF423); Region: DUF423; pfam04241 746697003664 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 746697003665 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 746697003666 active site 746697003667 substrate-binding site [chemical binding]; other site 746697003668 metal-binding site [ion binding] 746697003669 ATP binding site [chemical binding]; other site 746697003670 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 746697003671 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 746697003672 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 746697003673 dimer interface [polypeptide binding]; other site 746697003674 anticodon binding site; other site 746697003675 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 746697003676 homodimer interface [polypeptide binding]; other site 746697003677 motif 1; other site 746697003678 active site 746697003679 motif 2; other site 746697003680 GAD domain; Region: GAD; pfam02938 746697003681 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 746697003682 motif 3; other site 746697003683 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 746697003684 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 746697003685 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 746697003686 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697003687 Outer membrane efflux protein; Region: OEP; pfam02321 746697003688 Outer membrane efflux protein; Region: OEP; pfam02321 746697003689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746697003690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746697003691 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 746697003692 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 746697003693 substrate binding pocket [chemical binding]; other site 746697003694 chain length determination region; other site 746697003695 substrate-Mg2+ binding site; other site 746697003696 catalytic residues [active] 746697003697 aspartate-rich region 1; other site 746697003698 active site lid residues [active] 746697003699 aspartate-rich region 2; other site 746697003700 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 746697003701 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 746697003702 TPP-binding site [chemical binding]; other site 746697003703 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 746697003704 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 746697003705 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746697003706 E3 interaction surface; other site 746697003707 lipoyl attachment site [posttranslational modification]; other site 746697003708 e3 binding domain; Region: E3_binding; pfam02817 746697003709 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 746697003710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697003711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697003712 active site 746697003713 phosphorylation site [posttranslational modification] 746697003714 intermolecular recognition site; other site 746697003715 dimerization interface [polypeptide binding]; other site 746697003716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697003717 DNA binding residues [nucleotide binding] 746697003718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697003719 Histidine kinase; Region: HisKA_3; pfam07730 746697003720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697003721 ATP binding site [chemical binding]; other site 746697003722 Mg2+ binding site [ion binding]; other site 746697003723 G-X-G motif; other site 746697003724 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 746697003725 catalytic motif [active] 746697003726 Catalytic residue [active] 746697003727 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 746697003728 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 746697003729 active site 746697003730 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 746697003731 active site 746697003732 homodimer interface [polypeptide binding]; other site 746697003733 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 746697003734 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 746697003735 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697003736 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 746697003737 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 746697003738 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 746697003739 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 746697003740 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 746697003741 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 746697003742 putative dimer interface [polypeptide binding]; other site 746697003743 putative anticodon binding site; other site 746697003744 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 746697003745 homodimer interface [polypeptide binding]; other site 746697003746 motif 1; other site 746697003747 motif 2; other site 746697003748 active site 746697003749 motif 3; other site 746697003750 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 746697003751 ribosome recycling factor; Reviewed; Region: frr; PRK00083 746697003752 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 746697003753 hinge region; other site 746697003754 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 746697003755 putative nucleotide binding site [chemical binding]; other site 746697003756 uridine monophosphate binding site [chemical binding]; other site 746697003757 homohexameric interface [polypeptide binding]; other site 746697003758 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697003759 MG2 domain; Region: A2M_N; pfam01835 746697003760 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003761 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 746697003762 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 746697003763 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 746697003764 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 746697003765 L-aspartate oxidase; Provisional; Region: PRK06175 746697003766 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 746697003767 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 746697003768 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 746697003769 putative Iron-sulfur protein interface [polypeptide binding]; other site 746697003770 proximal heme binding site [chemical binding]; other site 746697003771 distal heme binding site [chemical binding]; other site 746697003772 putative dimer interface [polypeptide binding]; other site 746697003773 VPS10 domain; Region: VPS10; smart00602 746697003774 VPS10 domain; Region: VPS10; smart00602 746697003775 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746697003776 Beta-lactamase; Region: Beta-lactamase; pfam00144 746697003777 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 746697003778 Family description; Region: VCBS; pfam13517 746697003779 Family description; Region: VCBS; pfam13517 746697003780 Family description; Region: VCBS; pfam13517 746697003781 Family description; Region: VCBS; pfam13517 746697003782 Family description; Region: VCBS; pfam13517 746697003783 Family description; Region: VCBS; pfam13517 746697003784 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003785 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 746697003786 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 746697003787 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 746697003788 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 746697003789 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 746697003790 ligand binding site [chemical binding]; other site 746697003791 homodimer interface [polypeptide binding]; other site 746697003792 NAD(P) binding site [chemical binding]; other site 746697003793 trimer interface B [polypeptide binding]; other site 746697003794 trimer interface A [polypeptide binding]; other site 746697003795 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 746697003796 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 746697003797 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 746697003798 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 746697003799 NAD(P) binding site [chemical binding]; other site 746697003800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697003801 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 746697003802 active site 746697003803 phosphorylation site [posttranslational modification] 746697003804 intermolecular recognition site; other site 746697003805 dimerization interface [polypeptide binding]; other site 746697003806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697003807 Walker A motif; other site 746697003808 ATP binding site [chemical binding]; other site 746697003809 Walker B motif; other site 746697003810 arginine finger; other site 746697003811 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 746697003812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697003813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697003814 dimer interface [polypeptide binding]; other site 746697003815 phosphorylation site [posttranslational modification] 746697003816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697003817 ATP binding site [chemical binding]; other site 746697003818 Mg2+ binding site [ion binding]; other site 746697003819 G-X-G motif; other site 746697003820 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 746697003821 putative amphipathic alpha helix; other site 746697003822 Domain of unknown function (DUF329); Region: DUF329; cl01144 746697003823 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 746697003824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 746697003825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697003826 catalytic residue [active] 746697003827 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 746697003828 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 746697003829 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 746697003830 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 746697003831 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003832 active site 746697003833 HIGH motif; other site 746697003834 nucleotide binding site [chemical binding]; other site 746697003835 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003836 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697003837 active site 746697003838 KMSKS motif; other site 746697003839 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 746697003840 tRNA binding surface [nucleotide binding]; other site 746697003841 anticodon binding site; other site 746697003842 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 746697003843 lipoprotein signal peptidase; Provisional; Region: PRK14788 746697003844 Interferon-induced transmembrane protein; Region: CD225; pfam04505 746697003845 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 746697003846 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 746697003847 Predicted deacylase [General function prediction only]; Region: COG3608 746697003848 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 746697003849 putative active site [active] 746697003850 Zn binding site [ion binding]; other site 746697003851 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 746697003852 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697003853 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 746697003854 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 746697003855 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697003856 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 746697003857 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 746697003858 GIY-YIG motif/motif A; other site 746697003859 active site 746697003860 catalytic site [active] 746697003861 putative DNA binding site [nucleotide binding]; other site 746697003862 metal binding site [ion binding]; metal-binding site 746697003863 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 746697003864 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 746697003865 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 746697003866 DNA binding site [nucleotide binding] 746697003867 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 746697003868 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 746697003869 active site 746697003870 nucleophile elbow; other site 746697003871 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697003872 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 746697003873 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 746697003874 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 746697003875 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 746697003876 dimer interface [polypeptide binding]; other site 746697003877 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 746697003878 active site 746697003879 Fe binding site [ion binding]; other site 746697003880 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 746697003881 putative peptidase; Provisional; Region: PRK11649 746697003882 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697003883 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697003884 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697003885 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697003886 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697003887 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697003888 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697003889 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697003890 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697003891 putative catalytic site [active] 746697003892 putative metal binding site [ion binding]; other site 746697003893 putative phosphate binding site [ion binding]; other site 746697003894 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697003895 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697003896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746697003897 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746697003898 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 746697003899 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 746697003900 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 746697003901 HflX GTPase family; Region: HflX; cd01878 746697003902 G1 box; other site 746697003903 GTP/Mg2+ binding site [chemical binding]; other site 746697003904 Switch I region; other site 746697003905 G2 box; other site 746697003906 G3 box; other site 746697003907 Switch II region; other site 746697003908 G4 box; other site 746697003909 G5 box; other site 746697003910 Protein of unknown function (DUF3078); Region: DUF3078; pfam11276 746697003911 Protein of unknown function (DUF2480); Region: DUF2480; pfam10652 746697003912 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 746697003913 Fe-S metabolism associated domain; Region: SufE; cl00951 746697003914 META domain; Region: META; pfam03724 746697003915 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 746697003916 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 746697003917 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697003918 catalytic residue [active] 746697003919 FeS assembly protein SufD; Region: sufD; TIGR01981 746697003920 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 746697003921 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 746697003922 four helix bundle protein; Region: TIGR02436 746697003923 FeS assembly ATPase SufC; Region: sufC; TIGR01978 746697003924 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 746697003925 Walker A/P-loop; other site 746697003926 ATP binding site [chemical binding]; other site 746697003927 Q-loop/lid; other site 746697003928 ABC transporter signature motif; other site 746697003929 Walker B; other site 746697003930 D-loop; other site 746697003931 H-loop/switch region; other site 746697003932 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 746697003933 putative ABC transporter; Region: ycf24; CHL00085 746697003934 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 746697003935 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 746697003936 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 746697003937 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 746697003938 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003939 thiamine-monophosphate kinase; Region: thiL; TIGR01379 746697003940 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 746697003941 ATP binding site [chemical binding]; other site 746697003942 dimerization interface [polypeptide binding]; other site 746697003943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 746697003944 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 746697003945 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 746697003946 proline aminopeptidase P II; Provisional; Region: PRK10879 746697003947 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 746697003948 active site 746697003949 HD domain; Region: HD_3; pfam13023 746697003950 Predicted membrane protein [Function unknown]; Region: COG2323 746697003951 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697003952 putative catalytic site [active] 746697003953 putative metal binding site [ion binding]; other site 746697003954 putative phosphate binding site [ion binding]; other site 746697003955 PemK-like protein; Region: PemK; pfam02452 746697003956 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 746697003957 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697003958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697003959 TPR motif; other site 746697003960 binding surface 746697003961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697003962 binding surface 746697003963 TPR motif; other site 746697003964 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 746697003965 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 746697003966 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 746697003967 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 746697003968 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 746697003969 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 746697003970 NAD(P) binding site [chemical binding]; other site 746697003971 catalytic residues [active] 746697003972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 746697003973 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697003974 Coenzyme A binding pocket [chemical binding]; other site 746697003975 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 746697003976 Ferritin-like domain; Region: Ferritin; pfam00210 746697003977 ferroxidase diiron center [ion binding]; other site 746697003978 DNA repair protein RecO; Region: reco; TIGR00613 746697003979 Recombination protein O N terminal; Region: RecO_N; pfam11967 746697003980 Recombination protein O C terminal; Region: RecO_C; pfam02565 746697003981 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697003982 glutamate dehydrogenase; Provisional; Region: PRK09414 746697003983 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 746697003984 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 746697003985 NAD(P) binding site [chemical binding]; other site 746697003986 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 746697003987 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 746697003988 homodimer interface [polypeptide binding]; other site 746697003989 substrate-cofactor binding pocket; other site 746697003990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697003991 catalytic residue [active] 746697003992 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 746697003993 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 746697003994 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 746697003995 ArsC family; Region: ArsC; pfam03960 746697003996 catalytic residue [active] 746697003997 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 746697003998 EamA-like transporter family; Region: EamA; pfam00892 746697003999 EamA-like transporter family; Region: EamA; pfam00892 746697004000 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 746697004001 active site 746697004002 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 746697004003 hypothetical protein; Provisional; Region: PRK11820 746697004004 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 746697004005 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 746697004006 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 746697004007 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 746697004008 catalytic site [active] 746697004009 G-X2-G-X-G-K; other site 746697004010 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 746697004011 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 746697004012 active site 746697004013 (T/H)XGH motif; other site 746697004014 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 746697004015 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 746697004016 active site 746697004017 Domain of unknown function (DUF4271); Region: DUF4271; pfam14093 746697004018 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 746697004019 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 746697004020 Ligand binding site; other site 746697004021 Putative Catalytic site; other site 746697004022 DXD motif; other site 746697004023 dihydroorotase; Reviewed; Region: PRK09236 746697004024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 746697004025 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 746697004026 active site 746697004027 Domain of unknown function (DUF4296); Region: DUF4296; pfam14129 746697004028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697004029 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 746697004030 NAD(P) binding site [chemical binding]; other site 746697004031 active site 746697004032 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 746697004033 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 746697004034 active site 746697004035 HIGH motif; other site 746697004036 dimer interface [polypeptide binding]; other site 746697004037 KMSKS motif; other site 746697004038 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 746697004039 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746697004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004042 active site 746697004043 phosphorylation site [posttranslational modification] 746697004044 intermolecular recognition site; other site 746697004045 dimerization interface [polypeptide binding]; other site 746697004046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746697004047 DNA binding site [nucleotide binding] 746697004048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697004049 dimer interface [polypeptide binding]; other site 746697004050 phosphorylation site [posttranslational modification] 746697004051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004052 ATP binding site [chemical binding]; other site 746697004053 Mg2+ binding site [ion binding]; other site 746697004054 G-X-G motif; other site 746697004055 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 746697004056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697004057 S-adenosylmethionine binding site [chemical binding]; other site 746697004058 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 746697004059 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 746697004060 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 746697004061 DNA binding site [nucleotide binding] 746697004062 active site 746697004063 Fic family protein [Function unknown]; Region: COG3177 746697004064 Fic/DOC family; Region: Fic; pfam02661 746697004065 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 746697004066 Domain of unknown function DUF59; Region: DUF59; pfam01883 746697004067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 746697004068 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 746697004069 NifU-like domain; Region: NifU; pfam01106 746697004070 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 746697004071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746697004072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697004073 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 746697004074 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 746697004075 Autotransporter beta-domain; Region: Autotransporter; cl17461 746697004076 Imelysin; Region: Peptidase_M75; pfam09375 746697004077 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 746697004078 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 746697004079 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 746697004080 active site 746697004081 catalytic triad [active] 746697004082 oxyanion hole [active] 746697004083 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 746697004084 putative active site [active] 746697004085 putative metal binding site [ion binding]; other site 746697004086 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 746697004087 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 746697004088 active site 746697004089 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697004090 non-specific DNA binding site [nucleotide binding]; other site 746697004091 salt bridge; other site 746697004092 sequence-specific DNA binding site [nucleotide binding]; other site 746697004093 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 746697004094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697004095 S-adenosylmethionine binding site [chemical binding]; other site 746697004096 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 746697004097 RimM N-terminal domain; Region: RimM; pfam01782 746697004098 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521 746697004099 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 746697004100 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 746697004101 dinuclear metal binding motif [ion binding]; other site 746697004102 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 746697004103 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746697004104 active site 746697004105 catalytic site [active] 746697004106 substrate binding site [chemical binding]; other site 746697004107 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 746697004108 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 746697004109 active site 746697004110 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 746697004111 generic binding surface I; other site 746697004112 generic binding surface II; other site 746697004113 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746697004114 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697004115 catalytic residues [active] 746697004116 Clp protease; Region: CLP_protease; pfam00574 746697004117 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 746697004118 oligomer interface [polypeptide binding]; other site 746697004119 active site residues [active] 746697004120 Uncharacterized lipoprotein NlpE involved in copper resistance [Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism]; Region: CutF; COG3015 746697004121 NlpE N-terminal domain; Region: NlpE; pfam04170 746697004122 Protein of unknown function DUF58; Region: DUF58; pfam01882 746697004123 TIR domain; Region: TIR_2; pfam13676 746697004124 Caspase domain; Region: Peptidase_C14; pfam00656 746697004125 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 746697004126 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 746697004127 putative FMN binding site [chemical binding]; other site 746697004128 Penicillinase repressor; Region: Pencillinase_R; pfam03965 746697004129 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 746697004130 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 746697004131 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 746697004132 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192 746697004133 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 746697004134 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 746697004135 active site 746697004136 putative DNA-binding cleft [nucleotide binding]; other site 746697004137 dimer interface [polypeptide binding]; other site 746697004138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746697004139 Ion channel; Region: Ion_trans_2; pfam07885 746697004140 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 746697004141 membrane-bound complex binding site; other site 746697004142 hinge residues; other site 746697004143 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 746697004144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697004145 FeS/SAM binding site; other site 746697004146 HemN C-terminal domain; Region: HemN_C; pfam06969 746697004147 Putative cyclase; Region: Cyclase; pfam04199 746697004148 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 746697004149 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 746697004150 Protein of unknown function (DUF419); Region: DUF419; pfam04237 746697004151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697004152 Walker A/P-loop; other site 746697004153 ATP binding site [chemical binding]; other site 746697004154 Q-loop/lid; other site 746697004155 ABC transporter signature motif; other site 746697004156 Walker B; other site 746697004157 D-loop; other site 746697004158 H-loop/switch region; other site 746697004159 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 746697004160 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 746697004161 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 746697004162 DNA photolyase; Region: DNA_photolyase; pfam00875 746697004163 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 746697004164 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 746697004165 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 746697004166 Domain of unknown function DUF20; Region: UPF0118; pfam01594 746697004167 hypothetical protein; Provisional; Region: PRK06148 746697004168 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 746697004169 active site 746697004170 ATP binding site [chemical binding]; other site 746697004171 substrate binding site [chemical binding]; other site 746697004172 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697004173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 746697004174 inhibitor-cofactor binding pocket; inhibition site 746697004175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697004176 catalytic residue [active] 746697004177 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 746697004178 gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131 746697004179 Protein of unknown function (DUF805); Region: DUF805; pfam05656 746697004180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 746697004181 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697004182 substrate binding pocket [chemical binding]; other site 746697004183 putative lipid kinase; Reviewed; Region: PRK00861 746697004184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004185 binding surface 746697004186 TPR motif; other site 746697004187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004188 TPR repeat; Region: TPR_11; pfam13414 746697004189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697004190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004191 ATP binding site [chemical binding]; other site 746697004192 Mg2+ binding site [ion binding]; other site 746697004193 G-X-G motif; other site 746697004194 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 746697004195 HsdM N-terminal domain; Region: HsdM_N; pfam12161 746697004196 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746697004197 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 746697004198 HsdM N-terminal domain; Region: HsdM_N; pfam12161 746697004199 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746697004200 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 746697004201 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 746697004202 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 746697004203 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 746697004204 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 746697004205 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 746697004206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697004207 ATP binding site [chemical binding]; other site 746697004208 putative Mg++ binding site [ion binding]; other site 746697004209 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 746697004210 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 746697004211 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 746697004212 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004213 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004214 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004215 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004216 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004217 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004218 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004219 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004220 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 746697004221 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 746697004222 active site 746697004223 FMN binding site [chemical binding]; other site 746697004224 substrate binding site [chemical binding]; other site 746697004225 3Fe-4S cluster binding site [ion binding]; other site 746697004226 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004227 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004228 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004229 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004230 Uncharacterized conserved protein [Function unknown]; Region: COG3391 746697004231 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004232 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 746697004233 active site 746697004234 catalytic residues [active] 746697004235 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004236 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004237 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004238 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004239 FG-GAP repeat; Region: FG-GAP_2; pfam14312 746697004240 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004241 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 746697004242 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004244 TPR motif; other site 746697004245 binding surface 746697004246 CHAT domain; Region: CHAT; pfam12770 746697004247 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004248 binding surface 746697004249 Tetratricopeptide repeat; Region: TPR_16; pfam13432 746697004250 TPR motif; other site 746697004251 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697004252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697004253 diphosphomevalonate decarboxylase; Region: PLN02407 746697004254 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 746697004255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004256 binding surface 746697004257 TPR motif; other site 746697004258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004259 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004260 CHAT domain; Region: CHAT; pfam12770 746697004261 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 746697004262 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 746697004263 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 746697004264 UbiA prenyltransferase family; Region: UbiA; pfam01040 746697004265 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746697004266 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 746697004267 MutS domain I; Region: MutS_I; pfam01624 746697004268 MutS domain II; Region: MutS_II; pfam05188 746697004269 MutS domain III; Region: MutS_III; pfam05192 746697004270 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 746697004271 Walker A/P-loop; other site 746697004272 ATP binding site [chemical binding]; other site 746697004273 Q-loop/lid; other site 746697004274 ABC transporter signature motif; other site 746697004275 Walker B; other site 746697004276 D-loop; other site 746697004277 H-loop/switch region; other site 746697004278 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 746697004279 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 746697004280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697004281 FeS/SAM binding site; other site 746697004282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697004283 non-specific DNA binding site [nucleotide binding]; other site 746697004284 salt bridge; other site 746697004285 sequence-specific DNA binding site [nucleotide binding]; other site 746697004286 Predicted transcriptional regulator [Transcription]; Region: COG2932 746697004287 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 746697004288 Catalytic site [active] 746697004289 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 746697004290 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 746697004291 inhibitor-cofactor binding pocket; inhibition site 746697004292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697004293 catalytic residue [active] 746697004294 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 746697004295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697004296 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 746697004297 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 746697004298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697004299 catalytic residue [active] 746697004300 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 746697004301 Family description; Region: VCBS; pfam13517 746697004302 Family description; Region: VCBS; pfam13517 746697004303 Family description; Region: VCBS; pfam13517 746697004304 Family description; Region: VCBS; pfam13517 746697004305 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697004306 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697004307 ligand binding site [chemical binding]; other site 746697004308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697004309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697004310 dimer interface [polypeptide binding]; other site 746697004311 phosphorylation site [posttranslational modification] 746697004312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004313 ATP binding site [chemical binding]; other site 746697004314 Mg2+ binding site [ion binding]; other site 746697004315 G-X-G motif; other site 746697004316 Response regulator receiver domain; Region: Response_reg; pfam00072 746697004317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004318 active site 746697004319 phosphorylation site [posttranslational modification] 746697004320 intermolecular recognition site; other site 746697004321 dimerization interface [polypeptide binding]; other site 746697004322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697004323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697004324 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 746697004325 RNA/DNA hybrid binding site [nucleotide binding]; other site 746697004326 active site 746697004327 Domain of unknown function (DUF4289); Region: DUF4289; pfam14121 746697004328 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 746697004329 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 746697004330 FAD binding site [chemical binding]; other site 746697004331 homotetramer interface [polypeptide binding]; other site 746697004332 substrate binding pocket [chemical binding]; other site 746697004333 catalytic base [active] 746697004334 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 746697004335 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 746697004336 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 746697004337 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 746697004338 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 746697004339 NHAD transporter family protein; Provisional; Region: PLN00137 746697004340 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 746697004341 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 746697004342 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 746697004343 Gram-negative bacterial tonB protein; Region: TonB; cl10048 746697004344 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004345 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 746697004346 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697004347 Uncharacterized conserved protein [Function unknown]; Region: COG1284 746697004348 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 746697004349 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 746697004350 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 746697004351 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 746697004352 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 746697004353 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 746697004354 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746697004355 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697004356 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746697004357 gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524 746697004358 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258 746697004359 active site 746697004360 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 746697004361 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 746697004362 active site 746697004363 catalytic motif [active] 746697004364 Zn binding site [ion binding]; other site 746697004365 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 746697004366 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 746697004367 tetramer interface [polypeptide binding]; other site 746697004368 TPP-binding site [chemical binding]; other site 746697004369 heterodimer interface [polypeptide binding]; other site 746697004370 phosphorylation loop region [posttranslational modification] 746697004371 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746697004372 E3 interaction surface; other site 746697004373 lipoyl attachment site [posttranslational modification]; other site 746697004374 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 746697004375 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746697004376 E3 interaction surface; other site 746697004377 lipoyl attachment site [posttranslational modification]; other site 746697004378 e3 binding domain; Region: E3_binding; pfam02817 746697004379 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 746697004380 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 746697004381 classical (c) SDRs; Region: SDR_c; cd05233 746697004382 NAD(P) binding site [chemical binding]; other site 746697004383 active site 746697004384 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 746697004385 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 746697004386 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697004387 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 746697004388 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 746697004389 N-terminal plug; other site 746697004390 ligand-binding site [chemical binding]; other site 746697004391 SprT-like family; Region: SprT-like; pfam10263 746697004392 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 746697004393 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 746697004394 Substrate binding site; other site 746697004395 Domain of unknown function (DUF389); Region: DUF389; pfam04087 746697004396 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 746697004397 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 746697004398 Walker A/P-loop; other site 746697004399 ATP binding site [chemical binding]; other site 746697004400 Q-loop/lid; other site 746697004401 ABC transporter signature motif; other site 746697004402 Walker B; other site 746697004403 D-loop; other site 746697004404 H-loop/switch region; other site 746697004405 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 746697004406 Permease; Region: Permease; pfam02405 746697004407 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 746697004408 Alkaline phosphatase homologues; Region: alkPPc; smart00098 746697004409 active site 746697004410 dimer interface [polypeptide binding]; other site 746697004411 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697004412 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 746697004413 DXD motif; other site 746697004414 Methyltransferase domain; Region: Methyltransf_23; pfam13489 746697004415 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 746697004416 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 746697004417 dimer interface [polypeptide binding]; other site 746697004418 active site 746697004419 CoA binding pocket [chemical binding]; other site 746697004420 glycine dehydrogenase; Provisional; Region: PRK05367 746697004421 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 746697004422 tetramer interface [polypeptide binding]; other site 746697004423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697004424 catalytic residue [active] 746697004425 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 746697004426 tetramer interface [polypeptide binding]; other site 746697004427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697004428 catalytic residue [active] 746697004429 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 746697004430 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 746697004431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697004432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697004433 DNA binding residues [nucleotide binding] 746697004434 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697004435 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697004436 metal binding site [ion binding]; metal-binding site 746697004437 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004438 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 746697004439 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 746697004440 active site 746697004441 Zn binding site [ion binding]; other site 746697004442 AIR carboxylase; Region: AIRC; pfam00731 746697004443 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 746697004444 GIY-YIG motif/motif A; other site 746697004445 putative active site [active] 746697004446 putative metal binding site [ion binding]; other site 746697004447 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 746697004448 ATP-grasp domain; Region: ATP-grasp; pfam02222 746697004449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697004450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697004451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697004452 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 746697004453 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 746697004454 active site 746697004455 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 746697004456 Methyltransferase domain; Region: Methyltransf_12; pfam08242 746697004457 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 746697004458 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 746697004459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 746697004460 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 746697004461 Amidohydrolase; Region: Amidohydro_4; pfam13147 746697004462 active site 746697004463 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746697004464 Beta-lactamase; Region: Beta-lactamase; pfam00144 746697004465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004466 Tetratricopeptide repeat; Region: TPR_16; pfam13432 746697004467 TPR motif; other site 746697004468 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 746697004469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746697004470 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 746697004471 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 746697004472 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 746697004473 Substrate-binding site [chemical binding]; other site 746697004474 Substrate specificity [chemical binding]; other site 746697004475 GLPGLI family protein; Region: GLPGLI; TIGR01200 746697004476 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697004477 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 746697004478 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 746697004479 active site residue [active] 746697004480 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 746697004481 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 746697004482 cofactor binding site; other site 746697004483 metal binding site [ion binding]; metal-binding site 746697004484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746697004485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746697004486 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 746697004487 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 746697004488 FAD binding pocket [chemical binding]; other site 746697004489 FAD binding motif [chemical binding]; other site 746697004490 phosphate binding motif [ion binding]; other site 746697004491 beta-alpha-beta structure motif; other site 746697004492 NAD(p) ribose binding residues [chemical binding]; other site 746697004493 NAD binding pocket [chemical binding]; other site 746697004494 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 746697004495 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 746697004496 catalytic loop [active] 746697004497 iron binding site [ion binding]; other site 746697004498 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 746697004499 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 746697004500 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 746697004501 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 746697004502 four helix bundle protein; Region: TIGR02436 746697004503 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 746697004504 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 746697004505 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 746697004506 enoyl-CoA hydratase; Provisional; Region: PRK08140 746697004507 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 746697004508 substrate binding site [chemical binding]; other site 746697004509 oxyanion hole (OAH) forming residues; other site 746697004510 trimer interface [polypeptide binding]; other site 746697004511 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 746697004512 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 746697004513 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 746697004514 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 746697004515 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 746697004516 CoenzymeA binding site [chemical binding]; other site 746697004517 subunit interaction site [polypeptide binding]; other site 746697004518 PHB binding site; other site 746697004519 Predicted metalloprotease [General function prediction only]; Region: COG2321 746697004520 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 746697004521 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 746697004522 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 746697004523 dimer interface [polypeptide binding]; other site 746697004524 active site 746697004525 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 746697004526 PemK-like protein; Region: PemK; pfam02452 746697004527 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 746697004528 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 746697004529 substrate binding site [chemical binding]; other site 746697004530 dimer interface [polypeptide binding]; other site 746697004531 NADP binding site [chemical binding]; other site 746697004532 catalytic residues [active] 746697004533 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 746697004534 active site 2 [active] 746697004535 active site 1 [active] 746697004536 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 746697004537 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 746697004538 substrate binding site [chemical binding]; other site 746697004539 oxyanion hole (OAH) forming residues; other site 746697004540 trimer interface [polypeptide binding]; other site 746697004541 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 746697004542 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 746697004543 putative trimer interface [polypeptide binding]; other site 746697004544 putative metal binding site [ion binding]; other site 746697004545 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 746697004546 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746697004547 E3 interaction surface; other site 746697004548 lipoyl attachment site [posttranslational modification]; other site 746697004549 e3 binding domain; Region: E3_binding; pfam02817 746697004550 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 746697004551 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 746697004552 tetramer interface [polypeptide binding]; other site 746697004553 TPP-binding site [chemical binding]; other site 746697004554 heterodimer interface [polypeptide binding]; other site 746697004555 phosphorylation loop region [posttranslational modification] 746697004556 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 746697004557 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 746697004558 alpha subunit interface [polypeptide binding]; other site 746697004559 TPP binding site [chemical binding]; other site 746697004560 heterodimer interface [polypeptide binding]; other site 746697004561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746697004562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697004563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004564 active site 746697004565 phosphorylation site [posttranslational modification] 746697004566 intermolecular recognition site; other site 746697004567 dimerization interface [polypeptide binding]; other site 746697004568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697004569 DNA binding residues [nucleotide binding] 746697004570 dimerization interface [polypeptide binding]; other site 746697004571 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 746697004572 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697004574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004575 ATP binding site [chemical binding]; other site 746697004576 Mg2+ binding site [ion binding]; other site 746697004577 G-X-G motif; other site 746697004578 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004579 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 746697004580 trimer interface [polypeptide binding]; other site 746697004581 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 746697004582 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 746697004583 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 746697004584 Trp docking motif [polypeptide binding]; other site 746697004585 active site 746697004586 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004587 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697004588 putative metal binding site [ion binding]; other site 746697004589 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697004590 putative catalytic site [active] 746697004591 putative phosphate binding site [ion binding]; other site 746697004592 putative metal binding site [ion binding]; other site 746697004593 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 746697004594 urocanate hydratase; Provisional; Region: PRK05414 746697004595 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 746697004596 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 746697004597 motif 1; other site 746697004598 active site 746697004599 motif 2; other site 746697004600 motif 3; other site 746697004601 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 746697004602 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 746697004603 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697004604 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 746697004605 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 746697004606 DNA binding residues [nucleotide binding] 746697004607 LemA family; Region: LemA; cl00742 746697004608 Repair protein; Region: Repair_PSII; cl01535 746697004609 Repair protein; Region: Repair_PSII; pfam04536 746697004610 Repair protein; Region: Repair_PSII; pfam04536 746697004611 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746697004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697004613 S-adenosylmethionine binding site [chemical binding]; other site 746697004614 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697004615 Predicted membrane protein [Function unknown]; Region: COG2364 746697004616 GTP-binding protein Der; Reviewed; Region: PRK00093 746697004617 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 746697004618 G1 box; other site 746697004619 GTP/Mg2+ binding site [chemical binding]; other site 746697004620 Switch I region; other site 746697004621 G2 box; other site 746697004622 Switch II region; other site 746697004623 G3 box; other site 746697004624 G4 box; other site 746697004625 G5 box; other site 746697004626 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 746697004627 G1 box; other site 746697004628 GTP/Mg2+ binding site [chemical binding]; other site 746697004629 Switch I region; other site 746697004630 G2 box; other site 746697004631 G3 box; other site 746697004632 Switch II region; other site 746697004633 G4 box; other site 746697004634 G5 box; other site 746697004635 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 746697004636 GTPase Era; Reviewed; Region: era; PRK00089 746697004637 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 746697004638 G1 box; other site 746697004639 GTP/Mg2+ binding site [chemical binding]; other site 746697004640 Switch I region; other site 746697004641 G2 box; other site 746697004642 Switch II region; other site 746697004643 G3 box; other site 746697004644 G4 box; other site 746697004645 G5 box; other site 746697004646 KH domain; Region: KH_2; pfam07650 746697004647 GSCFA family; Region: GSCFA; pfam08885 746697004648 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 746697004649 Trp docking motif [polypeptide binding]; other site 746697004650 active site 746697004651 PQQ-like domain; Region: PQQ_2; pfam13360 746697004652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004653 TPR motif; other site 746697004654 binding surface 746697004655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004656 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004658 binding surface 746697004659 TPR motif; other site 746697004660 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004661 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 746697004663 Histidine kinase; Region: HisKA_3; pfam07730 746697004664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004665 ATP binding site [chemical binding]; other site 746697004666 Mg2+ binding site [ion binding]; other site 746697004667 G-X-G motif; other site 746697004668 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004670 TPR motif; other site 746697004671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004672 binding surface 746697004673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697004674 binding surface 746697004675 TPR motif; other site 746697004676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697004678 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 746697004679 Histidine kinase; Region: HisKA_3; pfam07730 746697004680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004681 ATP binding site [chemical binding]; other site 746697004682 Mg2+ binding site [ion binding]; other site 746697004683 G-X-G motif; other site 746697004684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697004685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004686 active site 746697004687 phosphorylation site [posttranslational modification] 746697004688 intermolecular recognition site; other site 746697004689 dimerization interface [polypeptide binding]; other site 746697004690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697004691 DNA binding residues [nucleotide binding] 746697004692 dimerization interface [polypeptide binding]; other site 746697004693 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697004694 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697004695 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697004696 metal binding site [ion binding]; metal-binding site 746697004697 S-adenosylmethionine synthetase; Validated; Region: PRK05250 746697004698 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 746697004699 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 746697004700 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 746697004701 Response regulator receiver domain; Region: Response_reg; pfam00072 746697004702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004703 active site 746697004704 phosphorylation site [posttranslational modification] 746697004705 intermolecular recognition site; other site 746697004706 dimerization interface [polypeptide binding]; other site 746697004707 Response regulator receiver domain; Region: Response_reg; pfam00072 746697004708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004709 active site 746697004710 phosphorylation site [posttranslational modification] 746697004711 intermolecular recognition site; other site 746697004712 dimerization interface [polypeptide binding]; other site 746697004713 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 746697004714 CheB methylesterase; Region: CheB_methylest; pfam01339 746697004715 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 746697004716 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 746697004717 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 746697004718 PAS fold; Region: PAS; pfam00989 746697004719 PAS domain; Region: PAS_9; pfam13426 746697004720 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 746697004721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 746697004722 putative active site [active] 746697004723 heme pocket [chemical binding]; other site 746697004724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697004725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697004726 dimer interface [polypeptide binding]; other site 746697004727 phosphorylation site [posttranslational modification] 746697004728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697004729 ATP binding site [chemical binding]; other site 746697004730 Mg2+ binding site [ion binding]; other site 746697004731 G-X-G motif; other site 746697004732 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 746697004733 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 746697004734 homodimer interface [polypeptide binding]; other site 746697004735 substrate-cofactor binding pocket; other site 746697004736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697004737 catalytic residue [active] 746697004738 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 746697004739 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 746697004740 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 746697004741 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 746697004742 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 746697004743 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 746697004744 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 746697004745 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 746697004746 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 746697004747 tetramer interface [polypeptide binding]; other site 746697004748 serine racemase; Region: PLN02970 746697004749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697004750 catalytic residue [active] 746697004751 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 746697004752 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 746697004753 substrate binding pocket [chemical binding]; other site 746697004754 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 746697004755 B12 binding site [chemical binding]; other site 746697004756 cobalt ligand [ion binding]; other site 746697004757 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 746697004758 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 746697004759 FAD binding site [chemical binding]; other site 746697004760 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 746697004761 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 746697004762 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 746697004763 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 746697004764 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 746697004765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746697004766 Walker A/P-loop; other site 746697004767 ATP binding site [chemical binding]; other site 746697004768 Q-loop/lid; other site 746697004769 ABC transporter signature motif; other site 746697004770 Walker B; other site 746697004771 D-loop; other site 746697004772 H-loop/switch region; other site 746697004773 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 746697004774 Prephenate dehydratase; Region: PDT; pfam00800 746697004775 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 746697004776 putative L-Phe binding site [chemical binding]; other site 746697004777 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 746697004778 Chorismate mutase type II; Region: CM_2; smart00830 746697004779 GTPase RsgA; Reviewed; Region: PRK00098 746697004780 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 746697004781 RNA binding site [nucleotide binding]; other site 746697004782 homodimer interface [polypeptide binding]; other site 746697004783 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 746697004784 GTPase/Zn-binding domain interface [polypeptide binding]; other site 746697004785 GTP/Mg2+ binding site [chemical binding]; other site 746697004786 G4 box; other site 746697004787 G5 box; other site 746697004788 G1 box; other site 746697004789 Switch I region; other site 746697004790 G2 box; other site 746697004791 G3 box; other site 746697004792 Switch II region; other site 746697004793 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 746697004794 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 746697004795 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 746697004796 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 746697004797 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 746697004798 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 746697004799 homodimer interface [polypeptide binding]; other site 746697004800 metal binding site [ion binding]; metal-binding site 746697004801 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 746697004802 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 746697004803 hinge; other site 746697004804 active site 746697004805 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 746697004806 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 746697004807 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 746697004808 active site 746697004809 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004810 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 746697004811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697004812 FeS/SAM binding site; other site 746697004813 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 746697004814 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697004815 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 746697004816 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 746697004817 substrate binding pocket [chemical binding]; other site 746697004818 chain length determination region; other site 746697004819 substrate-Mg2+ binding site; other site 746697004820 catalytic residues [active] 746697004821 aspartate-rich region 1; other site 746697004822 active site lid residues [active] 746697004823 aspartate-rich region 2; other site 746697004824 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 746697004825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697004826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697004827 DNA binding residues [nucleotide binding] 746697004828 DNA primase, catalytic core; Region: dnaG; TIGR01391 746697004829 CHC2 zinc finger; Region: zf-CHC2; cl17510 746697004830 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 746697004831 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 746697004832 active site 746697004833 metal binding site [ion binding]; metal-binding site 746697004834 interdomain interaction site; other site 746697004835 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 746697004836 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697004837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697004838 active site 746697004839 phosphorylation site [posttranslational modification] 746697004840 intermolecular recognition site; other site 746697004841 dimerization interface [polypeptide binding]; other site 746697004842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697004843 DNA binding residues [nucleotide binding] 746697004844 dimerization interface [polypeptide binding]; other site 746697004845 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 746697004846 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 746697004847 homodimer interface [polypeptide binding]; other site 746697004848 NAD binding pocket [chemical binding]; other site 746697004849 ATP binding pocket [chemical binding]; other site 746697004850 Mg binding site [ion binding]; other site 746697004851 active-site loop [active] 746697004852 gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514 746697004853 gliding motility-associated protein GldC; Region: GldC; TIGR03515 746697004854 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 746697004855 G1 box; other site 746697004856 GTP/Mg2+ binding site [chemical binding]; other site 746697004857 Switch I region; other site 746697004858 G2 box; other site 746697004859 G3 box; other site 746697004860 Switch II region; other site 746697004861 G4 box; other site 746697004862 G5 box; other site 746697004863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697004864 cell division protein MraZ; Reviewed; Region: PRK00326 746697004865 MraZ protein; Region: MraZ; pfam02381 746697004866 MraZ protein; Region: MraZ; pfam02381 746697004867 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 746697004868 MraW methylase family; Region: Methyltransf_5; cl17771 746697004869 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 746697004870 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 746697004871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 746697004872 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 746697004873 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 746697004874 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746697004875 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697004876 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746697004877 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 746697004878 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 746697004879 Mg++ binding site [ion binding]; other site 746697004880 putative catalytic motif [active] 746697004881 putative substrate binding site [chemical binding]; other site 746697004882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 746697004883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697004884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746697004885 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 746697004886 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 746697004887 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 746697004888 active site 746697004889 homodimer interface [polypeptide binding]; other site 746697004890 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 746697004891 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 746697004892 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 746697004893 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 746697004894 cell division protein FtsA; Region: ftsA; TIGR01174 746697004895 Cell division protein FtsA; Region: FtsA; smart00842 746697004896 Cell division protein FtsA; Region: FtsA; pfam14450 746697004897 cell division protein FtsZ; Validated; Region: PRK09330 746697004898 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 746697004899 nucleotide binding site [chemical binding]; other site 746697004900 SulA interaction site; other site 746697004901 Yqey-like protein; Region: YqeY; pfam09424 746697004902 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 746697004903 GIY-YIG motif/motif A; other site 746697004904 putative active site [active] 746697004905 putative metal binding site [ion binding]; other site 746697004906 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 746697004907 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 746697004908 DinB superfamily; Region: DinB_2; pfam12867 746697004909 hypothetical protein; Reviewed; Region: PRK00024 746697004910 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 746697004911 MPN+ (JAMM) motif; other site 746697004912 Zinc-binding site [ion binding]; other site 746697004913 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 746697004914 putative active site [active] 746697004915 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 746697004916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697004917 motif II; other site 746697004918 recombination factor protein RarA; Reviewed; Region: PRK13342 746697004919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697004920 Walker A motif; other site 746697004921 ATP binding site [chemical binding]; other site 746697004922 Walker B motif; other site 746697004923 arginine finger; other site 746697004924 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 746697004925 Rhomboid family; Region: Rhomboid; pfam01694 746697004926 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 746697004927 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 746697004928 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746697004929 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 746697004930 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697004931 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697004932 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697004933 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697004934 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 746697004935 S17 interaction site [polypeptide binding]; other site 746697004936 S8 interaction site; other site 746697004937 16S rRNA interaction site [nucleotide binding]; other site 746697004938 streptomycin interaction site [chemical binding]; other site 746697004939 23S rRNA interaction site [nucleotide binding]; other site 746697004940 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 746697004941 30S ribosomal protein S7; Validated; Region: PRK05302 746697004942 elongation factor G; Reviewed; Region: PRK12739 746697004943 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 746697004944 G1 box; other site 746697004945 putative GEF interaction site [polypeptide binding]; other site 746697004946 GTP/Mg2+ binding site [chemical binding]; other site 746697004947 Switch I region; other site 746697004948 G2 box; other site 746697004949 G3 box; other site 746697004950 Switch II region; other site 746697004951 G4 box; other site 746697004952 G5 box; other site 746697004953 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 746697004954 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 746697004955 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 746697004956 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 746697004957 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 746697004958 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 746697004959 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 746697004960 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 746697004961 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 746697004962 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 746697004963 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 746697004964 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 746697004965 putative translocon binding site; other site 746697004966 protein-rRNA interface [nucleotide binding]; other site 746697004967 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 746697004968 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 746697004969 G-X-X-G motif; other site 746697004970 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 746697004971 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 746697004972 23S rRNA interface [nucleotide binding]; other site 746697004973 5S rRNA interface [nucleotide binding]; other site 746697004974 putative antibiotic binding site [chemical binding]; other site 746697004975 L25 interface [polypeptide binding]; other site 746697004976 L27 interface [polypeptide binding]; other site 746697004977 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 746697004978 23S rRNA interface [nucleotide binding]; other site 746697004979 putative translocon interaction site; other site 746697004980 signal recognition particle (SRP54) interaction site; other site 746697004981 L23 interface [polypeptide binding]; other site 746697004982 trigger factor interaction site; other site 746697004983 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 746697004984 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 746697004985 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 746697004986 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 746697004987 RNA binding site [nucleotide binding]; other site 746697004988 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 746697004989 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 746697004990 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 746697004991 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 746697004992 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 746697004993 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 746697004994 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 746697004995 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 746697004996 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 746697004997 5S rRNA interface [nucleotide binding]; other site 746697004998 23S rRNA interface [nucleotide binding]; other site 746697004999 L5 interface [polypeptide binding]; other site 746697005000 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 746697005001 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 746697005002 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 746697005003 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 746697005004 23S rRNA binding site [nucleotide binding]; other site 746697005005 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 746697005006 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 746697005007 SecY translocase; Region: SecY; pfam00344 746697005008 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 746697005009 rRNA binding site [nucleotide binding]; other site 746697005010 predicted 30S ribosome binding site; other site 746697005011 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 746697005012 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 746697005013 30S ribosomal protein S13; Region: bact_S13; TIGR03631 746697005014 30S ribosomal protein S11; Validated; Region: PRK05309 746697005015 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 746697005016 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 746697005017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746697005018 RNA binding surface [nucleotide binding]; other site 746697005019 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 746697005020 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 746697005021 alphaNTD homodimer interface [polypeptide binding]; other site 746697005022 alphaNTD - beta interaction site [polypeptide binding]; other site 746697005023 alphaNTD - beta' interaction site [polypeptide binding]; other site 746697005024 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 746697005025 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 746697005026 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 746697005027 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 746697005028 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 746697005029 catalytic site [active] 746697005030 subunit interface [polypeptide binding]; other site 746697005031 enolase; Provisional; Region: eno; PRK00077 746697005032 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 746697005033 dimer interface [polypeptide binding]; other site 746697005034 metal binding site [ion binding]; metal-binding site 746697005035 substrate binding pocket [chemical binding]; other site 746697005036 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 746697005037 dimer interface [polypeptide binding]; other site 746697005038 Citrate synthase; Region: Citrate_synt; pfam00285 746697005039 active site 746697005040 citrylCoA binding site [chemical binding]; other site 746697005041 NADH binding [chemical binding]; other site 746697005042 cationic pore residues; other site 746697005043 oxalacetate/citrate binding site [chemical binding]; other site 746697005044 coenzyme A binding site [chemical binding]; other site 746697005045 catalytic triad [active] 746697005046 Amidinotransferase; Region: Amidinotransf; cl12043 746697005047 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 746697005048 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697005049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697005050 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 746697005051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697005052 putative substrate translocation pore; other site 746697005053 POT family; Region: PTR2; cl17359 746697005054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697005055 putative substrate translocation pore; other site 746697005056 POT family; Region: PTR2; cl17359 746697005057 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 746697005058 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 746697005059 Competence protein; Region: Competence; pfam03772 746697005060 NlpC/P60 family; Region: NLPC_P60; pfam00877 746697005061 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 746697005062 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 746697005063 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 746697005064 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 746697005065 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697005066 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 746697005067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 746697005068 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 746697005069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 746697005070 RNA binding surface [nucleotide binding]; other site 746697005071 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 746697005072 active site 746697005073 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 746697005074 active site 746697005075 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 746697005076 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005077 Family description; Region: VCBS; pfam13517 746697005078 Family description; Region: VCBS; pfam13517 746697005079 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005080 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005081 Peptidase S46; Region: Peptidase_S46; pfam10459 746697005082 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 746697005083 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 746697005084 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 746697005085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697005086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697005087 DNA binding residues [nucleotide binding] 746697005088 dimerization interface [polypeptide binding]; other site 746697005089 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 746697005090 dimerization interface [polypeptide binding]; other site 746697005091 substrate binding site [chemical binding]; other site 746697005092 active site 746697005093 calcium binding site [ion binding]; other site 746697005094 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 746697005095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697005096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746697005097 putative substrate translocation pore; other site 746697005098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697005099 Protein of unknown function (DUF808); Region: DUF808; cl01002 746697005100 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697005101 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 746697005102 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 746697005103 N-terminal plug; other site 746697005104 ligand-binding site [chemical binding]; other site 746697005105 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746697005106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697005107 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697005108 ABC transporter; Region: ABC_tran_2; pfam12848 746697005109 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697005110 DJ-1 family protein; Region: not_thiJ; TIGR01383 746697005111 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 746697005112 conserved cys residue [active] 746697005113 Domain of unknown function (DUF4251); Region: DUF4251; pfam14059 746697005114 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 746697005115 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 746697005116 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 746697005117 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 746697005118 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746697005119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697005120 active site 746697005121 phosphorylation site [posttranslational modification] 746697005122 intermolecular recognition site; other site 746697005123 dimerization interface [polypeptide binding]; other site 746697005124 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746697005125 DNA binding site [nucleotide binding] 746697005126 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 746697005127 pentamer interface [polypeptide binding]; other site 746697005128 dodecaamer interface [polypeptide binding]; other site 746697005129 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 746697005130 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 746697005131 TrkA-C domain; Region: TrkA_C; pfam02080 746697005132 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 746697005133 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 746697005134 hypothetical protein; Validated; Region: PRK02101 746697005135 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 746697005136 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 746697005137 putative active site [active] 746697005138 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 746697005139 HYR domain; Region: HYR; pfam02494 746697005140 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005141 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 746697005142 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005143 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 746697005144 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 746697005145 active site 746697005146 Zn binding site [ion binding]; other site 746697005147 Peptidase S46; Region: Peptidase_S46; pfam10459 746697005148 transcription elongation factor regulatory protein; Validated; Region: PRK06342 746697005149 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 746697005150 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 746697005151 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 746697005152 dimer interface [polypeptide binding]; other site 746697005153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697005154 catalytic residue [active] 746697005155 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 746697005156 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 746697005157 PspC domain; Region: PspC; cl00864 746697005158 Ion channel; Region: Ion_trans_2; pfam07885 746697005159 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 746697005160 TrkA-N domain; Region: TrkA_N; pfam02254 746697005161 TrkA-C domain; Region: TrkA_C; pfam02080 746697005162 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 746697005163 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 746697005164 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 746697005165 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 746697005166 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 746697005167 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 746697005168 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 746697005169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 746697005170 active site 746697005171 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697005172 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 746697005173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746697005174 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 746697005175 active site 746697005176 DNA binding site [nucleotide binding] 746697005177 Int/Topo IB signature motif; other site 746697005178 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 746697005179 30S subunit binding site; other site 746697005180 elongation factor Tu; Reviewed; Region: PRK12735 746697005181 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 746697005182 G1 box; other site 746697005183 GEF interaction site [polypeptide binding]; other site 746697005184 GTP/Mg2+ binding site [chemical binding]; other site 746697005185 Switch I region; other site 746697005186 G2 box; other site 746697005187 G3 box; other site 746697005188 Switch II region; other site 746697005189 G4 box; other site 746697005190 G5 box; other site 746697005191 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 746697005192 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 746697005193 Antibiotic Binding Site [chemical binding]; other site 746697005194 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 746697005195 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 746697005196 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 746697005197 putative homodimer interface [polypeptide binding]; other site 746697005198 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 746697005199 heterodimer interface [polypeptide binding]; other site 746697005200 homodimer interface [polypeptide binding]; other site 746697005201 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 746697005202 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 746697005203 23S rRNA interface [nucleotide binding]; other site 746697005204 L7/L12 interface [polypeptide binding]; other site 746697005205 putative thiostrepton binding site; other site 746697005206 L25 interface [polypeptide binding]; other site 746697005207 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 746697005208 mRNA/rRNA interface [nucleotide binding]; other site 746697005209 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 746697005210 23S rRNA interface [nucleotide binding]; other site 746697005211 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 746697005212 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 746697005213 core dimer interface [polypeptide binding]; other site 746697005214 peripheral dimer interface [polypeptide binding]; other site 746697005215 L10 interface [polypeptide binding]; other site 746697005216 L11 interface [polypeptide binding]; other site 746697005217 putative EF-Tu interaction site [polypeptide binding]; other site 746697005218 putative EF-G interaction site [polypeptide binding]; other site 746697005219 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 746697005220 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 746697005221 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 746697005222 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 746697005223 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 746697005224 RPB11 interaction site [polypeptide binding]; other site 746697005225 RPB12 interaction site [polypeptide binding]; other site 746697005226 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 746697005227 RPB3 interaction site [polypeptide binding]; other site 746697005228 RPB1 interaction site [polypeptide binding]; other site 746697005229 RPB11 interaction site [polypeptide binding]; other site 746697005230 RPB10 interaction site [polypeptide binding]; other site 746697005231 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 746697005232 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 746697005233 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 746697005234 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 746697005235 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 746697005236 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 746697005237 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 746697005238 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 746697005239 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 746697005240 DNA binding site [nucleotide binding] 746697005241 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 746697005242 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 746697005243 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 746697005244 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 746697005245 G1 box; other site 746697005246 putative GEF interaction site [polypeptide binding]; other site 746697005247 GTP/Mg2+ binding site [chemical binding]; other site 746697005248 Switch I region; other site 746697005249 G2 box; other site 746697005250 G3 box; other site 746697005251 Switch II region; other site 746697005252 G4 box; other site 746697005253 G5 box; other site 746697005254 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 746697005255 Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573 746697005256 C-terminal domain of CHU protein family; Region: CHU_C; pfam13585 746697005257 Protein of unknown function (DUF3308); Region: DUF3308; pfam11751 746697005258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005259 binding surface 746697005260 TPR motif; other site 746697005261 Tetratricopeptide repeat; Region: TPR_16; pfam13432 746697005262 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 746697005263 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697005264 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697005265 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697005266 ligand binding site [chemical binding]; other site 746697005267 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 746697005268 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 746697005269 active site 746697005270 metal binding site [ion binding]; metal-binding site 746697005271 nudix motif; other site 746697005272 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 746697005273 active site 746697005274 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 746697005275 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 746697005276 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 746697005277 Protein of unknown function (DUF819); Region: DUF819; cl02317 746697005278 Lipase (class 2); Region: Lipase_2; pfam01674 746697005279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697005280 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 746697005281 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 746697005282 Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199 746697005283 active site 746697005284 ligand binding site [chemical binding]; other site 746697005285 NAD(P) binding site [chemical binding]; other site 746697005286 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 746697005287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697005288 NAD(P) binding site [chemical binding]; other site 746697005289 active site 746697005290 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 746697005291 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 746697005292 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 746697005293 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 746697005294 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 746697005295 Inner membrane protein CreD; Region: CreD; pfam06123 746697005296 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 746697005297 Transcriptional regulators [Transcription]; Region: MarR; COG1846 746697005298 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 746697005299 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 746697005300 Family description; Region: VCBS; pfam13517 746697005301 Family description; Region: VCBS; pfam13517 746697005302 Family description; Region: VCBS; pfam13517 746697005303 Family description; Region: VCBS; pfam13517 746697005304 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005305 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 746697005306 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 746697005307 G1 box; other site 746697005308 putative GEF interaction site [polypeptide binding]; other site 746697005309 GTP/Mg2+ binding site [chemical binding]; other site 746697005310 Switch I region; other site 746697005311 G2 box; other site 746697005312 G3 box; other site 746697005313 Switch II region; other site 746697005314 G4 box; other site 746697005315 G5 box; other site 746697005316 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 746697005317 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 746697005318 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 746697005319 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 746697005320 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 746697005321 inhibitor-cofactor binding pocket; inhibition site 746697005322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697005323 catalytic residue [active] 746697005324 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 746697005325 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 746697005326 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 746697005327 trimer interface [polypeptide binding]; other site 746697005328 active site 746697005329 substrate binding site [chemical binding]; other site 746697005330 CoA binding site [chemical binding]; other site 746697005331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005332 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 746697005333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005334 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 746697005335 putative ADP-binding pocket [chemical binding]; other site 746697005336 WxcM-like, C-terminal; Region: FdtA; pfam05523 746697005337 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697005338 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746697005339 active site 746697005340 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 746697005341 active site 746697005342 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 746697005343 Methyltransferase domain; Region: Methyltransf_11; pfam08241 746697005344 Methyltransferase domain; Region: Methyltransf_23; pfam13489 746697005345 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 746697005346 active site 746697005347 catalytic residues [active] 746697005348 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 746697005349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697005350 Walker A/P-loop; other site 746697005351 ATP binding site [chemical binding]; other site 746697005352 Q-loop/lid; other site 746697005353 ABC transporter signature motif; other site 746697005354 Walker B; other site 746697005355 D-loop; other site 746697005356 H-loop/switch region; other site 746697005357 Transposase IS200 like; Region: Y1_Tnp; cl00848 746697005358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005359 TPR motif; other site 746697005360 binding surface 746697005361 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 746697005362 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 746697005363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005364 binding surface 746697005365 TPR motif; other site 746697005366 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 746697005367 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697005368 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 746697005369 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 746697005370 active site 746697005371 Flagellin N-methylase; Region: FliB; pfam03692 746697005372 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 746697005373 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 746697005374 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746697005375 FtsX-like permease family; Region: FtsX; pfam02687 746697005376 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 746697005377 active site 746697005378 Zn binding site [ion binding]; other site 746697005379 Predicted membrane protein [Function unknown]; Region: COG4270 746697005380 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 746697005381 HYR domain; Region: HYR; pfam02494 746697005382 HYR domain; Region: HYR; pfam02494 746697005383 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005384 heat shock protein 90; Provisional; Region: PRK05218 746697005385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697005386 ATP binding site [chemical binding]; other site 746697005387 Mg2+ binding site [ion binding]; other site 746697005388 G-X-G motif; other site 746697005389 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 746697005390 ABC1 family; Region: ABC1; cl17513 746697005391 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 746697005392 active site 746697005393 ATP binding site [chemical binding]; other site 746697005394 substrate binding site [chemical binding]; other site 746697005395 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 746697005396 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 746697005397 dimer interface [polypeptide binding]; other site 746697005398 active site 746697005399 CoA binding pocket [chemical binding]; other site 746697005400 CoA binding domain; Region: CoA_binding_2; pfam13380 746697005401 Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326 746697005402 Na binding site [ion binding]; other site 746697005403 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005404 recombination protein RecR; Reviewed; Region: recR; PRK00076 746697005405 RecR protein; Region: RecR; pfam02132 746697005406 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 746697005407 putative active site [active] 746697005408 putative metal-binding site [ion binding]; other site 746697005409 tetramer interface [polypeptide binding]; other site 746697005410 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 746697005411 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 746697005412 Probable Catalytic site; other site 746697005413 metal-binding site 746697005414 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 746697005415 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 746697005416 E3 interaction surface; other site 746697005417 lipoyl attachment site [posttranslational modification]; other site 746697005418 e3 binding domain; Region: E3_binding; pfam02817 746697005419 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 746697005420 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 746697005421 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746697005422 active site 746697005423 catalytic site [active] 746697005424 substrate binding site [chemical binding]; other site 746697005425 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 746697005426 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 746697005427 competence damage-inducible protein A; Provisional; Region: PRK00549 746697005428 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 746697005429 putative MPT binding site; other site 746697005430 Competence-damaged protein; Region: CinA; pfam02464 746697005431 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 746697005432 ribosomal protein L33; Region: rpl33; CHL00104 746697005433 Domain of unknown function (DUF4295); Region: DUF4295; pfam14128 746697005434 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 746697005435 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 746697005436 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 746697005437 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 746697005438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697005439 Beta-lactamase; Region: Beta-lactamase; pfam00144 746697005440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746697005441 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 746697005442 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 746697005443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 746697005444 FeS/SAM binding site; other site 746697005445 Predicted membrane protein [Function unknown]; Region: COG4818 746697005446 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 746697005447 Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903 746697005448 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697005449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697005450 active site 746697005451 phosphorylation site [posttranslational modification] 746697005452 intermolecular recognition site; other site 746697005453 dimerization interface [polypeptide binding]; other site 746697005454 LytTr DNA-binding domain; Region: LytTR; smart00850 746697005455 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 746697005456 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 746697005457 Histidine kinase; Region: His_kinase; pfam06580 746697005458 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005460 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 746697005461 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697005462 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 746697005463 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 746697005464 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 746697005465 active site 746697005466 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 746697005467 multidrug efflux protein; Reviewed; Region: PRK01766 746697005468 cation binding site [ion binding]; other site 746697005469 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cl10033 746697005470 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238 746697005471 putative active site [active] 746697005472 Zn binding site [ion binding]; other site 746697005473 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 746697005474 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 746697005475 Zn binding site [ion binding]; other site 746697005476 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 746697005477 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 746697005478 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 746697005479 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 746697005480 catalytic residues [active] 746697005481 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 746697005482 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 746697005483 FMN binding site [chemical binding]; other site 746697005484 active site 746697005485 catalytic residues [active] 746697005486 substrate binding site [chemical binding]; other site 746697005487 Sensors of blue-light using FAD; Region: BLUF; pfam04940 746697005488 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746697005489 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746697005490 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 746697005491 Walker A/P-loop; other site 746697005492 ATP binding site [chemical binding]; other site 746697005493 Q-loop/lid; other site 746697005494 ABC transporter signature motif; other site 746697005495 Walker B; other site 746697005496 D-loop; other site 746697005497 H-loop/switch region; other site 746697005498 Transposase IS200 like; Region: Y1_Tnp; cl00848 746697005499 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 746697005500 nucleotide binding site [chemical binding]; other site 746697005501 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746697005502 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 746697005503 active site 746697005504 catalytic site [active] 746697005505 substrate binding site [chemical binding]; other site 746697005506 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 746697005507 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 746697005508 catalytic residues [active] 746697005509 dimer interface [polypeptide binding]; other site 746697005510 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 746697005511 active site 746697005512 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 746697005513 active site 746697005514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746697005515 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 746697005516 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 746697005517 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 746697005518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 746697005519 active site 746697005520 phosphorylation site [posttranslational modification] 746697005521 intermolecular recognition site; other site 746697005522 dimerization interface [polypeptide binding]; other site 746697005523 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 746697005524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697005525 active site 746697005526 phosphorylation site [posttranslational modification] 746697005527 intermolecular recognition site; other site 746697005528 dimerization interface [polypeptide binding]; other site 746697005529 hypothetical protein; Provisional; Region: PRK13560 746697005530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 746697005531 putative active site [active] 746697005532 heme pocket [chemical binding]; other site 746697005533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 746697005534 putative active site [active] 746697005535 heme pocket [chemical binding]; other site 746697005536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697005537 dimer interface [polypeptide binding]; other site 746697005538 phosphorylation site [posttranslational modification] 746697005539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697005540 ATP binding site [chemical binding]; other site 746697005541 Mg2+ binding site [ion binding]; other site 746697005542 G-X-G motif; other site 746697005543 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 746697005544 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 746697005545 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 746697005546 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 746697005547 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 746697005548 Domain of unknown function (DUF202); Region: DUF202; cl09954 746697005549 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 746697005550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697005551 Walker A motif; other site 746697005552 ATP binding site [chemical binding]; other site 746697005553 Walker B motif; other site 746697005554 arginine finger; other site 746697005555 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 746697005556 malate:quinone oxidoreductase; Validated; Region: PRK05257 746697005557 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 746697005558 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 746697005559 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746697005560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697005561 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 746697005562 PspC domain; Region: PspC; pfam04024 746697005563 Predicted transcriptional regulators [Transcription]; Region: COG1695 746697005564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746697005565 putative Zn2+ binding site [ion binding]; other site 746697005566 putative DNA binding site [nucleotide binding]; other site 746697005567 Tic20-like protein; Region: Tic20; pfam09685 746697005568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746697005569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746697005570 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 746697005571 dimerization interface [polypeptide binding]; other site 746697005572 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 746697005573 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 746697005574 Protein of unknown function DUF58; Region: DUF58; pfam01882 746697005575 MoxR-like ATPases [General function prediction only]; Region: COG0714 746697005576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697005577 Walker A motif; other site 746697005578 ATP binding site [chemical binding]; other site 746697005579 Walker B motif; other site 746697005580 arginine finger; other site 746697005581 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 746697005582 Integral membrane protein DUF95; Region: DUF95; pfam01944 746697005583 RDD family; Region: RDD; pfam06271 746697005584 Predicted membrane protein [Function unknown]; Region: COG2860 746697005585 UPF0126 domain; Region: UPF0126; pfam03458 746697005586 UPF0126 domain; Region: UPF0126; pfam03458 746697005587 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 746697005588 active site 746697005589 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 746697005590 putative active site [active] 746697005591 putative CoA binding site [chemical binding]; other site 746697005592 nudix motif; other site 746697005593 metal binding site [ion binding]; metal-binding site 746697005594 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 746697005595 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 746697005596 putative acyl-acceptor binding pocket; other site 746697005597 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697005598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697005599 DNA binding residues [nucleotide binding] 746697005600 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 746697005601 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 746697005602 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 746697005603 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697005604 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 746697005605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697005606 sequence-specific DNA binding site [nucleotide binding]; other site 746697005607 salt bridge; other site 746697005608 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697005609 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697005610 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697005611 Histidine kinase; Region: His_kinase; pfam06580 746697005612 2TM domain; Region: 2TM; pfam13239 746697005613 2TM domain; Region: 2TM; pfam13239 746697005614 2TM domain; Region: 2TM; pfam13239 746697005615 2TM domain; Region: 2TM; pfam13239 746697005616 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 746697005617 aromatic arch; other site 746697005618 DCoH dimer interaction site [polypeptide binding]; other site 746697005619 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 746697005620 DCoH tetramer interaction site [polypeptide binding]; other site 746697005621 substrate binding site [chemical binding]; other site 746697005622 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 746697005623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697005624 NAD(P) binding site [chemical binding]; other site 746697005625 active site 746697005626 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 746697005627 glutaminase; Provisional; Region: PRK00971 746697005628 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 746697005629 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 746697005630 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 746697005631 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 746697005632 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 746697005633 NAD(P) binding site [chemical binding]; other site 746697005634 catalytic residues [active] 746697005635 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 746697005636 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 746697005637 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 746697005638 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 746697005639 active site 746697005640 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 746697005641 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 746697005642 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 746697005643 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 746697005644 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 746697005645 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697005646 active site 746697005647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 746697005648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697005649 NAD(P) binding site [chemical binding]; other site 746697005650 active site 746697005651 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005652 Sulfatase; Region: Sulfatase; pfam00884 746697005653 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 746697005654 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 746697005655 membrane ATPase/protein kinase; Provisional; Region: PRK09435 746697005656 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 746697005657 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 746697005658 Walker A; other site 746697005659 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 746697005660 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 746697005661 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 746697005662 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697005663 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697005664 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697005665 DNA binding residues [nucleotide binding] 746697005666 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005667 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697005668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005669 binding surface 746697005670 TPR motif; other site 746697005671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697005672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697005673 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697005674 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 746697005675 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 746697005676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 746697005677 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 746697005678 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 746697005679 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 746697005680 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746697005681 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746697005682 Walker A/P-loop; other site 746697005683 ATP binding site [chemical binding]; other site 746697005684 Q-loop/lid; other site 746697005685 ABC transporter signature motif; other site 746697005686 Walker B; other site 746697005687 D-loop; other site 746697005688 H-loop/switch region; other site 746697005689 Methyltransferase domain; Region: Methyltransf_24; pfam13578 746697005690 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 746697005691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697005692 Walker A/P-loop; other site 746697005693 ATP binding site [chemical binding]; other site 746697005694 Q-loop/lid; other site 746697005695 ABC transporter signature motif; other site 746697005696 Walker B; other site 746697005697 D-loop; other site 746697005698 H-loop/switch region; other site 746697005699 ABC transporter; Region: ABC_tran_2; pfam12848 746697005700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697005701 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 746697005702 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 746697005703 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 746697005704 Chain length determinant protein; Region: Wzz; cl15801 746697005705 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 746697005706 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 746697005707 GIY-YIG motif/motif A; other site 746697005708 putative active site [active] 746697005709 putative metal binding site [ion binding]; other site 746697005710 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 746697005711 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 746697005712 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 746697005713 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 746697005714 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 746697005715 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 746697005716 NAD binding site [chemical binding]; other site 746697005717 substrate binding site [chemical binding]; other site 746697005718 homodimer interface [polypeptide binding]; other site 746697005719 active site 746697005720 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cl00049 746697005721 heterodimerization interface [polypeptide binding]; other site 746697005722 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 746697005723 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 746697005724 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 746697005725 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 746697005726 Walker A/P-loop; other site 746697005727 ATP binding site [chemical binding]; other site 746697005728 Q-loop/lid; other site 746697005729 ABC transporter signature motif; other site 746697005730 Walker B; other site 746697005731 D-loop; other site 746697005732 H-loop/switch region; other site 746697005733 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 746697005734 putative carbohydrate binding site [chemical binding]; other site 746697005735 Methyltransferase domain; Region: Methyltransf_24; pfam13578 746697005736 Protein of unknown function (DUF616); Region: DUF616; pfam04765 746697005737 Methyltransferase domain; Region: Methyltransf_23; pfam13489 746697005738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697005739 S-adenosylmethionine binding site [chemical binding]; other site 746697005740 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697005741 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 746697005742 Probable Catalytic site; other site 746697005743 metal-binding site 746697005744 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697005745 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746697005746 active site 746697005747 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 746697005748 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 746697005749 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 746697005750 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005751 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697005752 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005753 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697005754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697005755 active site 746697005756 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 746697005757 putative ADP-binding pocket [chemical binding]; other site 746697005758 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 746697005759 putative active site [active] 746697005760 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 746697005761 Ligand Binding Site [chemical binding]; other site 746697005762 Molecular Tunnel; other site 746697005763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005764 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697005765 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 746697005766 putative ADP-binding pocket [chemical binding]; other site 746697005767 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005768 Exostosin family; Region: Exostosin; pfam03016 746697005769 Phosphotransferase enzyme family; Region: APH; pfam01636 746697005770 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 746697005771 substrate binding site [chemical binding]; other site 746697005772 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005773 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697005774 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 746697005775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 746697005776 active site 746697005777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005778 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697005779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005780 Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534 746697005781 O-Antigen ligase; Region: Wzy_C; pfam04932 746697005782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005783 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697005784 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 746697005785 Bacterial sugar transferase; Region: Bac_transf; pfam02397 746697005786 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 746697005787 archaetidylserine synthase; Region: archae_ser_T; TIGR04217 746697005788 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 746697005789 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 746697005790 Walker A/P-loop; other site 746697005791 ATP binding site [chemical binding]; other site 746697005792 Q-loop/lid; other site 746697005793 ABC transporter signature motif; other site 746697005794 Walker B; other site 746697005795 D-loop; other site 746697005796 H-loop/switch region; other site 746697005797 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 746697005798 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 746697005799 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 746697005800 putative active site [active] 746697005801 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 746697005802 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 746697005803 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697005804 ATP binding site [chemical binding]; other site 746697005805 putative Mg++ binding site [ion binding]; other site 746697005806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697005807 nucleotide binding region [chemical binding]; other site 746697005808 ATP-binding site [chemical binding]; other site 746697005809 RQC domain; Region: RQC; pfam09382 746697005810 HRDC domain; Region: HRDC; pfam00570 746697005811 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 746697005812 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 746697005813 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 746697005814 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 746697005815 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 746697005816 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 746697005817 active site 746697005818 NTP binding site [chemical binding]; other site 746697005819 metal binding triad [ion binding]; metal-binding site 746697005820 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 746697005821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697005822 Zn2+ binding site [ion binding]; other site 746697005823 Mg2+ binding site [ion binding]; other site 746697005824 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 746697005825 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 746697005826 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 746697005827 putative ADP-binding pocket [chemical binding]; other site 746697005828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697005829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697005830 active site 746697005831 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 746697005832 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 746697005833 Probable Catalytic site; other site 746697005834 metal-binding site 746697005835 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 746697005836 Substrate binding site; other site 746697005837 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 746697005838 metal-binding site 746697005839 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697005840 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 746697005841 putative metal binding site; other site 746697005842 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 746697005843 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 746697005844 putative active site [active] 746697005845 putative metal binding site [ion binding]; other site 746697005846 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 746697005847 putative metal binding site; other site 746697005848 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697005849 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 746697005850 Substrate binding site; other site 746697005851 metal-binding site 746697005852 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697005853 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 746697005854 Substrate binding site; other site 746697005855 metal-binding site 746697005856 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 746697005857 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 746697005858 putative active site [active] 746697005859 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 746697005860 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 746697005861 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 746697005862 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 746697005863 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 746697005864 trimer interface [polypeptide binding]; other site 746697005865 active site 746697005866 substrate binding site [chemical binding]; other site 746697005867 CoA binding site [chemical binding]; other site 746697005868 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 746697005869 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 746697005870 active site 746697005871 catalytic residues [active] 746697005872 metal binding site [ion binding]; metal-binding site 746697005873 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 746697005874 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 746697005875 homodimer interface [polypeptide binding]; other site 746697005876 metal binding site [ion binding]; metal-binding site 746697005877 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 746697005878 homodimer interface [polypeptide binding]; other site 746697005879 active site 746697005880 putative chemical substrate binding site [chemical binding]; other site 746697005881 metal binding site [ion binding]; metal-binding site 746697005882 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 746697005883 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 746697005884 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 746697005885 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 746697005886 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 746697005887 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 746697005888 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 746697005889 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 746697005890 shikimate binding site; other site 746697005891 NAD(P) binding site [chemical binding]; other site 746697005892 Domain of unknown function (DUF368); Region: DUF368; pfam04018 746697005893 Domain of unknown function (DUF368); Region: DUF368; cl00893 746697005894 Domain of unknown function (DUF368); Region: DUF368; pfam04018 746697005895 TPR repeat; Region: TPR_11; pfam13414 746697005896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005897 binding surface 746697005898 TPR motif; other site 746697005899 Tetratricopeptide repeat; Region: TPR_16; pfam13432 746697005900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005901 binding surface 746697005902 TPR repeat; Region: TPR_11; pfam13414 746697005903 TPR motif; other site 746697005904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005905 TPR motif; other site 746697005906 TPR repeat; Region: TPR_11; pfam13414 746697005907 binding surface 746697005908 TPR repeat; Region: TPR_11; pfam13414 746697005909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005910 binding surface 746697005911 TPR motif; other site 746697005912 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 746697005913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 746697005914 inhibitor-cofactor binding pocket; inhibition site 746697005915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697005916 catalytic residue [active] 746697005917 OstA-like protein; Region: OstA_2; pfam13100 746697005918 OstA-like protein; Region: OstA; cl00844 746697005919 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 746697005920 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 746697005921 GDP-binding site [chemical binding]; other site 746697005922 ACT binding site; other site 746697005923 IMP binding site; other site 746697005924 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 746697005925 metal binding site 2 [ion binding]; metal-binding site 746697005926 putative DNA binding helix; other site 746697005927 metal binding site 1 [ion binding]; metal-binding site 746697005928 dimer interface [polypeptide binding]; other site 746697005929 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 746697005930 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697005931 Zn2+ binding site [ion binding]; other site 746697005932 Mg2+ binding site [ion binding]; other site 746697005933 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 746697005934 synthetase active site [active] 746697005935 NTP binding site [chemical binding]; other site 746697005936 metal binding site [ion binding]; metal-binding site 746697005937 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 746697005938 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 746697005939 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267 746697005940 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005941 Transposase; Region: DEDD_Tnp_IS110; pfam01548 746697005942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 746697005943 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 746697005944 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697005945 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697005946 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697005947 catalytic residues [active] 746697005948 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697005949 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697005950 catalytic residues [active] 746697005951 Protein of unknown function (DUF3738); Region: DUF3738; cl11887 746697005952 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 746697005953 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 746697005954 cofactor binding site; other site 746697005955 DNA binding site [nucleotide binding] 746697005956 substrate interaction site [chemical binding]; other site 746697005957 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 746697005958 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 746697005959 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 746697005960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697005961 non-specific DNA binding site [nucleotide binding]; other site 746697005962 salt bridge; other site 746697005963 sequence-specific DNA binding site [nucleotide binding]; other site 746697005964 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697005965 AIPR protein; Region: AIPR; pfam10592 746697005966 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005967 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 746697005968 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 746697005969 active site 746697005970 DNA binding site [nucleotide binding] 746697005971 Int/Topo IB signature motif; other site 746697005972 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 746697005973 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 746697005974 active site 746697005975 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005976 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 746697005977 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 746697005978 active site 746697005979 Zn binding site [ion binding]; other site 746697005980 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005981 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005982 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 746697005983 Peptidase family M28; Region: Peptidase_M28; pfam04389 746697005984 metal binding site [ion binding]; metal-binding site 746697005985 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697005986 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697005987 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697005988 Predicted integral membrane protein [Function unknown]; Region: COG5616 746697005989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697005990 TPR motif; other site 746697005991 binding surface 746697005992 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 746697005993 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 746697005994 generic binding surface II; other site 746697005995 ssDNA binding site; other site 746697005996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697005997 ATP binding site [chemical binding]; other site 746697005998 putative Mg++ binding site [ion binding]; other site 746697005999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697006000 nucleotide binding region [chemical binding]; other site 746697006001 ATP-binding site [chemical binding]; other site 746697006002 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 746697006003 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 746697006004 Zn binding site [ion binding]; other site 746697006005 Patatin-like phospholipase; Region: Patatin; pfam01734 746697006006 active site 746697006007 nucleophile elbow; other site 746697006008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697006009 Histidine kinase; Region: HisKA_3; pfam07730 746697006010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697006011 ATP binding site [chemical binding]; other site 746697006012 Mg2+ binding site [ion binding]; other site 746697006013 G-X-G motif; other site 746697006014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697006015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697006016 active site 746697006017 phosphorylation site [posttranslational modification] 746697006018 intermolecular recognition site; other site 746697006019 dimerization interface [polypeptide binding]; other site 746697006020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697006021 DNA binding residues [nucleotide binding] 746697006022 dimerization interface [polypeptide binding]; other site 746697006023 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006024 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 746697006025 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 746697006026 active site 746697006027 FMN binding site [chemical binding]; other site 746697006028 substrate binding site [chemical binding]; other site 746697006029 3Fe-4S cluster binding site [ion binding]; other site 746697006030 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 746697006031 Part of AAA domain; Region: AAA_19; pfam13245 746697006032 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 746697006033 Family description; Region: UvrD_C_2; pfam13538 746697006034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697006035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697006036 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 746697006037 SnoaL-like domain; Region: SnoaL_2; pfam12680 746697006038 tellurium resistance terB-like protein; Region: terB_like; cl11965 746697006039 metal binding site [ion binding]; metal-binding site 746697006040 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697006041 ligand binding site [chemical binding]; other site 746697006042 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 746697006043 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 746697006044 Probable Catalytic site; other site 746697006045 metal-binding site 746697006046 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 746697006047 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 746697006048 DNA polymerase III, delta subunit; Region: holA; TIGR01128 746697006049 Predicted membrane protein [Function unknown]; Region: COG2259 746697006050 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 746697006051 UbiA prenyltransferase family; Region: UbiA; pfam01040 746697006052 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 746697006053 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 746697006054 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 746697006055 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 746697006056 active site 746697006057 CAAX protease self-immunity; Region: Abi; pfam02517 746697006058 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746697006059 AMP binding site [chemical binding]; other site 746697006060 active site 746697006061 acyl-activating enzyme (AAE) consensus motif; other site 746697006062 CoA binding site [chemical binding]; other site 746697006063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697006064 active site 746697006065 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 746697006066 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 746697006067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697006068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697006069 ABC transporter; Region: ABC_tran_2; pfam12848 746697006070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697006071 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 746697006072 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 746697006073 NAD(P) binding site [chemical binding]; other site 746697006074 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006075 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 746697006076 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 746697006077 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 746697006078 putative active site [active] 746697006079 putative metal binding site [ion binding]; other site 746697006080 imidazolonepropionase; Validated; Region: PRK09356 746697006081 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 746697006082 active site 746697006083 Cadherin repeat-like domain; Region: CA_like; cl15786 746697006084 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 746697006085 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 746697006086 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 746697006087 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 746697006088 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 746697006089 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 746697006090 protein binding site [polypeptide binding]; other site 746697006091 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 746697006092 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 746697006093 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 746697006094 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 746697006095 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746697006096 YceG-like family; Region: YceG; pfam02618 746697006097 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 746697006098 dimerization interface [polypeptide binding]; other site 746697006099 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 746697006100 putative SAM binding site [chemical binding]; other site 746697006101 homodimer interface [polypeptide binding]; other site 746697006102 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 746697006103 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006104 Low molecular weight phosphatase family; Region: LMWPc; cd00115 746697006105 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 746697006106 active site 746697006107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746697006108 DNA-binding site [nucleotide binding]; DNA binding site 746697006109 RNA-binding motif; other site 746697006110 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 746697006111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697006112 NAD(P) binding site [chemical binding]; other site 746697006113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697006114 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 746697006115 active site 746697006116 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 746697006117 DEAD-like helicases superfamily; Region: DEXDc; smart00487 746697006118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697006119 ATP binding site [chemical binding]; other site 746697006120 putative Mg++ binding site [ion binding]; other site 746697006121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697006122 nucleotide binding region [chemical binding]; other site 746697006123 ATP-binding site [chemical binding]; other site 746697006124 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 746697006125 helicase 45; Provisional; Region: PTZ00424 746697006126 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 746697006127 ATP binding site [chemical binding]; other site 746697006128 Mg++ binding site [ion binding]; other site 746697006129 motif III; other site 746697006130 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697006131 nucleotide binding region [chemical binding]; other site 746697006132 ATP-binding site [chemical binding]; other site 746697006133 ribonuclease Z; Reviewed; Region: PRK00055 746697006134 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 746697006135 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 746697006136 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 746697006137 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746697006138 catalytic core [active] 746697006139 polyphosphate kinase; Provisional; Region: PRK05443 746697006140 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 746697006141 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 746697006142 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 746697006143 domain interface [polypeptide binding]; other site 746697006144 active site 746697006145 catalytic site [active] 746697006146 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 746697006147 domain interface [polypeptide binding]; other site 746697006148 active site 746697006149 catalytic site [active] 746697006150 exopolyphosphatase; Region: exo_poly_only; TIGR03706 746697006151 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 746697006152 DinB family; Region: DinB; cl17821 746697006153 DinB superfamily; Region: DinB_2; pfam12867 746697006154 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 746697006155 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 746697006156 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 746697006157 dimerization interface [polypeptide binding]; other site 746697006158 active site 746697006159 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 746697006160 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 746697006161 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697006162 primosomal protein N' Region: priA; TIGR00595 746697006163 ATP binding site [chemical binding]; other site 746697006164 putative Mg++ binding site [ion binding]; other site 746697006165 helicase superfamily c-terminal domain; Region: HELICc; smart00490 746697006166 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697006167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697006168 active site 746697006169 phosphorylation site [posttranslational modification] 746697006170 intermolecular recognition site; other site 746697006171 dimerization interface [polypeptide binding]; other site 746697006172 LytTr DNA-binding domain; Region: LytTR; pfam04397 746697006173 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 746697006174 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 746697006175 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 746697006176 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 746697006177 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 746697006178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746697006179 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 746697006180 FtsX-like permease family; Region: FtsX; pfam02687 746697006181 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 746697006182 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 746697006183 dimer interface [polypeptide binding]; other site 746697006184 motif 1; other site 746697006185 active site 746697006186 motif 2; other site 746697006187 motif 3; other site 746697006188 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 746697006189 anticodon binding site; other site 746697006190 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 746697006191 hydrophobic ligand binding site; other site 746697006192 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 746697006193 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 746697006194 homodimer interface [polypeptide binding]; other site 746697006195 substrate-cofactor binding pocket; other site 746697006196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697006197 catalytic residue [active] 746697006198 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 746697006199 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 746697006200 IHF - DNA interface [nucleotide binding]; other site 746697006201 IHF dimer interface [polypeptide binding]; other site 746697006202 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 746697006203 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 746697006204 putative active site [active] 746697006205 substrate binding site [chemical binding]; other site 746697006206 putative cosubstrate binding site; other site 746697006207 catalytic site [active] 746697006208 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 746697006209 substrate binding site [chemical binding]; other site 746697006210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 746697006211 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 746697006212 ATP binding site [chemical binding]; other site 746697006213 putative Mg++ binding site [ion binding]; other site 746697006214 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697006215 nucleotide binding region [chemical binding]; other site 746697006216 ATP-binding site [chemical binding]; other site 746697006217 Predicted ATPase [General function prediction only]; Region: COG3911 746697006218 AAA domain; Region: AAA_28; pfam13521 746697006219 Protein of unknown function (DUF493); Region: DUF493; pfam04359 746697006220 Domain of unknown function (DUF4290); Region: DUF4290; pfam14123 746697006221 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 746697006222 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 746697006223 hinge; other site 746697006224 active site 746697006225 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 746697006226 DNA photolyase; Region: DNA_photolyase; pfam00875 746697006227 classical (c) SDRs; Region: SDR_c; cd05233 746697006228 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 746697006229 NAD(P) binding site [chemical binding]; other site 746697006230 active site 746697006231 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 746697006232 putative hydrophobic ligand binding site [chemical binding]; other site 746697006233 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 746697006234 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 746697006235 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697006236 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697006237 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697006238 DNA binding residues [nucleotide binding] 746697006239 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 746697006240 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 746697006241 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 746697006242 Walker A/P-loop; other site 746697006243 ATP binding site [chemical binding]; other site 746697006244 Q-loop/lid; other site 746697006245 ABC transporter signature motif; other site 746697006246 Walker B; other site 746697006247 D-loop; other site 746697006248 H-loop/switch region; other site 746697006249 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 746697006250 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 746697006251 active site 746697006252 substrate binding site [chemical binding]; other site 746697006253 metal binding site [ion binding]; metal-binding site 746697006254 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 746697006255 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 746697006256 Ligand binding site; other site 746697006257 Putative Catalytic site; other site 746697006258 DXD motif; other site 746697006259 Protein of unknown function (DUF4199); Region: DUF4199; pfam13858 746697006260 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 746697006261 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 746697006262 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 746697006263 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 746697006264 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 746697006265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697006266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697006267 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 746697006268 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 746697006269 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697006270 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 746697006271 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746697006272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746697006273 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 746697006274 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 746697006275 adenylosuccinate lyase; Provisional; Region: PRK09285 746697006276 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 746697006277 tetramer interface [polypeptide binding]; other site 746697006278 active site 746697006279 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697006280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697006281 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 746697006282 Clp amino terminal domain; Region: Clp_N; pfam02861 746697006283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697006284 Walker A motif; other site 746697006285 ATP binding site [chemical binding]; other site 746697006286 Walker B motif; other site 746697006287 arginine finger; other site 746697006288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697006289 Walker A motif; other site 746697006290 ATP binding site [chemical binding]; other site 746697006291 Walker B motif; other site 746697006292 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 746697006293 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746697006294 catalytic residues [active] 746697006295 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 746697006296 fumarylacetoacetase; Region: PLN02856 746697006297 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 746697006298 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 746697006299 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 746697006300 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 746697006301 dimer interface [polypeptide binding]; other site 746697006302 active site 746697006303 glycine-pyridoxal phosphate binding site [chemical binding]; other site 746697006304 folate binding site [chemical binding]; other site 746697006305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746697006306 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 746697006307 PGAP1-like protein; Region: PGAP1; pfam07819 746697006308 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697006309 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 746697006310 nucleoside/Zn binding site; other site 746697006311 dimer interface [polypeptide binding]; other site 746697006312 catalytic motif [active] 746697006313 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 746697006314 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 746697006315 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 746697006316 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697006317 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 746697006318 short chain dehydrogenase; Provisional; Region: PRK06179 746697006319 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 746697006320 NADP binding site [chemical binding]; other site 746697006321 active site 746697006322 steroid binding site; other site 746697006323 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 746697006324 active site 746697006325 intersubunit interactions; other site 746697006326 catalytic residue [active] 746697006327 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697006328 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 746697006329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697006330 Walker A/P-loop; other site 746697006331 ATP binding site [chemical binding]; other site 746697006332 Q-loop/lid; other site 746697006333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697006334 ABC transporter signature motif; other site 746697006335 Walker B; other site 746697006336 D-loop; other site 746697006337 ABC transporter; Region: ABC_tran_2; pfam12848 746697006338 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 746697006339 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 746697006340 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 746697006341 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 746697006342 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 746697006343 Interdomain contacts; other site 746697006344 Cytokine receptor motif; other site 746697006345 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 746697006346 Interdomain contacts; other site 746697006347 Cytokine receptor motif; other site 746697006348 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 746697006349 CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast; Region: CUB; cd00041 746697006350 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006351 Fasciclin domain; Region: Fasciclin; pfam02469 746697006352 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 746697006353 Fasciclin domain; Region: Fasciclin; pfam02469 746697006354 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 746697006355 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 746697006356 putative tRNA-binding site [nucleotide binding]; other site 746697006357 B3/4 domain; Region: B3_4; pfam03483 746697006358 tRNA synthetase B5 domain; Region: B5; pfam03484 746697006359 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 746697006360 dimer interface [polypeptide binding]; other site 746697006361 motif 1; other site 746697006362 motif 3; other site 746697006363 motif 2; other site 746697006364 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 746697006365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 746697006366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 746697006367 Family description; Region: VCBS; pfam13517 746697006368 Family description; Region: VCBS; pfam13517 746697006369 Family description; Region: VCBS; pfam13517 746697006370 Family description; Region: VCBS; pfam13517 746697006371 Family description; Region: VCBS; pfam13517 746697006372 Family description; Region: VCBS; pfam13517 746697006373 Family description; Region: VCBS; pfam13517 746697006374 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006375 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 746697006376 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 746697006377 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 746697006378 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 746697006379 CARDB; Region: CARDB; pfam07705 746697006380 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746697006382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697006383 non-specific DNA binding site [nucleotide binding]; other site 746697006384 salt bridge; other site 746697006385 sequence-specific DNA binding site [nucleotide binding]; other site 746697006386 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006387 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 746697006388 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 746697006389 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 746697006390 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 746697006391 metal binding site [ion binding]; metal-binding site 746697006392 dimer interface [polypeptide binding]; other site 746697006393 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 746697006394 active site 746697006395 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 746697006396 peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516 746697006397 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 746697006398 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 746697006399 DHH family; Region: DHH; pfam01368 746697006400 DHHA1 domain; Region: DHHA1; pfam02272 746697006401 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 746697006402 active site 746697006403 multimer interface [polypeptide binding]; other site 746697006404 Protein of unknown function (DUF721); Region: DUF721; pfam05258 746697006405 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 746697006406 recombination protein F; Reviewed; Region: recF; PRK00064 746697006407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697006408 Walker A/P-loop; other site 746697006409 ATP binding site [chemical binding]; other site 746697006410 Q-loop/lid; other site 746697006411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697006412 ABC transporter signature motif; other site 746697006413 Walker B; other site 746697006414 D-loop; other site 746697006415 H-loop/switch region; other site 746697006416 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 746697006417 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 746697006418 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 746697006419 TPR motif; other site 746697006420 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 746697006421 homopentamer interface [polypeptide binding]; other site 746697006422 active site 746697006423 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 746697006424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697006425 ATP binding site [chemical binding]; other site 746697006426 Mg2+ binding site [ion binding]; other site 746697006427 G-X-G motif; other site 746697006428 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 746697006429 ATP binding site [chemical binding]; other site 746697006430 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 746697006431 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 746697006432 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 746697006433 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 746697006434 putative catalytic site [active] 746697006435 putative metal binding site [ion binding]; other site 746697006436 putative phosphate binding site [ion binding]; other site 746697006437 WbqC-like protein family; Region: WbqC; pfam08889 746697006438 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 746697006439 AAA domain; Region: AAA_18; pfam13238 746697006440 ATP-binding site [chemical binding]; other site 746697006441 Sugar specificity; other site 746697006442 Pyrimidine base specificity; other site 746697006443 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 746697006444 heterodimer interface [polypeptide binding]; other site 746697006445 substrate interaction site [chemical binding]; other site 746697006446 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 746697006447 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 746697006448 active site 746697006449 substrate binding site [chemical binding]; other site 746697006450 coenzyme B12 binding site [chemical binding]; other site 746697006451 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 746697006452 B12 binding site [chemical binding]; other site 746697006453 cobalt ligand [ion binding]; other site 746697006454 AAA ATPase domain; Region: AAA_15; pfam13175 746697006455 DNA topoisomerase VI subunit B; Provisional; Region: PRK14867 746697006456 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697006457 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006458 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 746697006459 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 746697006460 Cl- selectivity filter; other site 746697006461 Cl- binding residues [ion binding]; other site 746697006462 pore gating glutamate residue; other site 746697006463 dimer interface [polypeptide binding]; other site 746697006464 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 746697006465 active site 746697006466 dinuclear metal binding site [ion binding]; other site 746697006467 dimerization interface [polypeptide binding]; other site 746697006468 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 746697006469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697006470 Walker A motif; other site 746697006471 ATP binding site [chemical binding]; other site 746697006472 Walker B motif; other site 746697006473 arginine finger; other site 746697006474 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 746697006475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697006476 S-adenosylmethionine binding site [chemical binding]; other site 746697006477 Protein of unknown function (DUF3822); Region: DUF3822; pfam12864 746697006478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697006479 Walker A motif; other site 746697006480 ATP binding site [chemical binding]; other site 746697006481 Walker B motif; other site 746697006482 arginine finger; other site 746697006483 Family description; Region: UvrD_C_2; pfam13538 746697006484 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 746697006485 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 746697006486 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 746697006487 Ligand binding site; other site 746697006488 oligomer interface; other site 746697006489 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 746697006490 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 746697006491 active site 746697006492 NAD binding site [chemical binding]; other site 746697006493 metal binding site [ion binding]; metal-binding site 746697006494 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 746697006495 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 746697006496 putative acyl-acceptor binding pocket; other site 746697006497 hypothetical protein; Provisional; Region: PRK12378 746697006498 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 746697006499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697006500 active site 746697006501 phosphorylation site [posttranslational modification] 746697006502 intermolecular recognition site; other site 746697006503 dimerization interface [polypeptide binding]; other site 746697006504 LytTr DNA-binding domain; Region: LytTR; smart00850 746697006505 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 746697006506 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 746697006507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697006508 TPR motif; other site 746697006509 binding surface 746697006510 Anti-sigma-K factor rskA; Region: RskA; pfam10099 746697006511 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697006512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697006513 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 746697006514 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 746697006515 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 746697006516 Zn binding site [ion binding]; other site 746697006517 HYR domain; Region: HYR; pfam02494 746697006518 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006519 Predicted flavoprotein [General function prediction only]; Region: COG0431 746697006520 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 746697006521 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 746697006522 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 746697006523 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 746697006524 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 746697006525 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 746697006526 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 746697006527 Ligand Binding Site [chemical binding]; other site 746697006528 TilS substrate C-terminal domain; Region: TilS_C; smart00977 746697006529 Predicted acyl esterases [General function prediction only]; Region: COG2936 746697006530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 746697006531 6-phosphofructokinase; Provisional; Region: PRK03202 746697006532 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 746697006533 active site 746697006534 ADP/pyrophosphate binding site [chemical binding]; other site 746697006535 dimerization interface [polypeptide binding]; other site 746697006536 allosteric effector site; other site 746697006537 fructose-1,6-bisphosphate binding site; other site 746697006538 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 746697006539 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 746697006540 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 746697006541 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 746697006542 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 746697006543 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 746697006544 active site 746697006545 dimer interface [polypeptide binding]; other site 746697006546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 746697006547 dimer interface [polypeptide binding]; other site 746697006548 active site 746697006549 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 746697006550 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 746697006551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697006552 Walker A motif; other site 746697006553 ATP binding site [chemical binding]; other site 746697006554 Walker B motif; other site 746697006555 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 746697006556 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 746697006557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697006558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697006559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697006560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697006561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 746697006562 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 746697006563 von Willebrand factor type A domain; Region: VWA_2; pfam13519 746697006564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697006565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697006566 ATP binding site [chemical binding]; other site 746697006567 Mg2+ binding site [ion binding]; other site 746697006568 G-X-G motif; other site 746697006569 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697006570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697006571 active site 746697006572 phosphorylation site [posttranslational modification] 746697006573 intermolecular recognition site; other site 746697006574 dimerization interface [polypeptide binding]; other site 746697006575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697006576 DNA binding residues [nucleotide binding] 746697006577 dimerization interface [polypeptide binding]; other site 746697006578 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 746697006579 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 746697006580 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 746697006581 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 746697006582 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 746697006583 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 746697006584 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 746697006585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697006586 Histidine kinase; Region: HisKA_3; pfam07730 746697006587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697006588 ATP binding site [chemical binding]; other site 746697006589 Mg2+ binding site [ion binding]; other site 746697006590 G-X-G motif; other site 746697006591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697006592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697006593 active site 746697006594 phosphorylation site [posttranslational modification] 746697006595 intermolecular recognition site; other site 746697006596 dimerization interface [polypeptide binding]; other site 746697006597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697006598 dimerization interface [polypeptide binding]; other site 746697006599 DNA binding residues [nucleotide binding] 746697006600 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 746697006601 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 746697006602 active site 746697006603 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 746697006604 oligomerization interface [polypeptide binding]; other site 746697006605 active site 746697006606 metal binding site [ion binding]; metal-binding site 746697006607 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 746697006608 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 746697006609 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 746697006610 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 746697006611 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 746697006612 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 746697006613 active site 746697006614 DNA binding site [nucleotide binding] 746697006615 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 746697006616 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 746697006617 active site 746697006618 PHP Thumb interface [polypeptide binding]; other site 746697006619 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 746697006620 generic binding surface I; other site 746697006621 generic binding surface II; other site 746697006622 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006623 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 746697006624 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 746697006625 nucleotide binding site [chemical binding]; other site 746697006626 NEF interaction site [polypeptide binding]; other site 746697006627 SBD interface [polypeptide binding]; other site 746697006628 bile acid transporter; Region: bass; TIGR00841 746697006629 Sodium Bile acid symporter family; Region: SBF; cl17470 746697006630 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 746697006631 putative hydrophobic ligand binding site [chemical binding]; other site 746697006632 Predicted esterase [General function prediction only]; Region: COG0400 746697006633 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 746697006634 CoenzymeA binding site [chemical binding]; other site 746697006635 subunit interaction site [polypeptide binding]; other site 746697006636 PHB binding site; other site 746697006637 chorismate binding enzyme; Region: Chorismate_bind; cl10555 746697006638 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 746697006639 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 746697006640 dimer interface [polypeptide binding]; other site 746697006641 tetramer interface [polypeptide binding]; other site 746697006642 PYR/PP interface [polypeptide binding]; other site 746697006643 TPP binding site [chemical binding]; other site 746697006644 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 746697006645 TPP-binding site; other site 746697006646 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 746697006647 S1 domain; Region: S1_2; pfam13509 746697006648 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 746697006649 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 746697006650 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 746697006651 substrate binding site [chemical binding]; other site 746697006652 oxyanion hole (OAH) forming residues; other site 746697006653 trimer interface [polypeptide binding]; other site 746697006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697006655 S-adenosylmethionine binding site [chemical binding]; other site 746697006656 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 746697006657 Fatty acid desaturase; Region: FA_desaturase; pfam00487 746697006658 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 746697006659 Di-iron ligands [ion binding]; other site 746697006660 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 746697006661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697006662 binding surface 746697006663 TPR motif; other site 746697006664 TPR repeat; Region: TPR_11; pfam13414 746697006665 TPR repeat; Region: TPR_11; pfam13414 746697006666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697006667 binding surface 746697006668 TPR motif; other site 746697006669 asparagine synthetase B; Provisional; Region: asnB; PRK09431 746697006670 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 746697006671 active site 746697006672 dimer interface [polypeptide binding]; other site 746697006673 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 746697006674 Ligand Binding Site [chemical binding]; other site 746697006675 Molecular Tunnel; other site 746697006676 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 746697006677 DEAD-like helicases superfamily; Region: DEXDc; smart00487 746697006678 ATP binding site [chemical binding]; other site 746697006679 Mg++ binding site [ion binding]; other site 746697006680 motif III; other site 746697006681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697006682 nucleotide binding region [chemical binding]; other site 746697006683 ATP-binding site [chemical binding]; other site 746697006684 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 746697006685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 746697006686 ATP binding site [chemical binding]; other site 746697006687 putative Mg++ binding site [ion binding]; other site 746697006688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 746697006689 nucleotide binding region [chemical binding]; other site 746697006690 ATP-binding site [chemical binding]; other site 746697006691 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 746697006692 RNA binding site [nucleotide binding]; other site 746697006693 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 746697006694 HSP70 interaction site [polypeptide binding]; other site 746697006695 KTSC domain; Region: KTSC; pfam13619 746697006696 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 746697006697 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697006698 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697006699 ligand binding site [chemical binding]; other site 746697006700 putative carbohydrate kinase; Provisional; Region: PRK10565 746697006701 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 746697006702 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 746697006703 putative substrate binding site [chemical binding]; other site 746697006704 putative ATP binding site [chemical binding]; other site 746697006705 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 746697006706 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 746697006707 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697006708 catalytic residue [active] 746697006709 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697006710 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697006711 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697006712 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697006713 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 746697006714 Cell division protein ZapA; Region: ZapA; pfam05164 746697006715 phosphodiesterase; Provisional; Region: PRK12704 746697006716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697006717 Zn2+ binding site [ion binding]; other site 746697006718 Mg2+ binding site [ion binding]; other site 746697006719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 746697006720 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 746697006721 active site 746697006722 catalytic tetrad [active] 746697006723 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 746697006724 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 746697006725 active site 746697006726 Int/Topo IB signature motif; other site 746697006727 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697006728 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697006729 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697006730 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697006731 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697006732 Dehydroquinase class II; Region: DHquinase_II; pfam01220 746697006733 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 746697006734 active site 746697006735 trimer interface [polypeptide binding]; other site 746697006736 dimer interface [polypeptide binding]; other site 746697006737 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 746697006738 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746697006739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697006740 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746697006741 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 746697006742 SelR domain; Region: SelR; pfam01641 746697006743 methionine sulfoxide reductase B; Provisional; Region: PRK00222 746697006744 SelR domain; Region: SelR; pfam01641 746697006745 Peptidase family M48; Region: Peptidase_M48; pfam01435 746697006746 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 746697006747 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 746697006748 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 746697006749 Found in ATP-dependent protease La (LON); Region: LON; smart00464 746697006750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697006751 Walker A motif; other site 746697006752 ATP binding site [chemical binding]; other site 746697006753 Walker B motif; other site 746697006754 arginine finger; other site 746697006755 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 746697006756 cytidylate kinase; Provisional; Region: cmk; PRK00023 746697006757 AAA domain; Region: AAA_17; pfam13207 746697006758 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 746697006759 CMP-binding site; other site 746697006760 The sites determining sugar specificity; other site 746697006761 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 746697006762 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 746697006763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697006764 non-specific DNA binding site [nucleotide binding]; other site 746697006765 salt bridge; other site 746697006766 sequence-specific DNA binding site [nucleotide binding]; other site 746697006767 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 746697006768 putative active site [active] 746697006769 Zn binding site [ion binding]; other site 746697006770 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 746697006771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 746697006772 putative DNA binding site [nucleotide binding]; other site 746697006773 putative Zn2+ binding site [ion binding]; other site 746697006774 AsnC family; Region: AsnC_trans_reg; pfam01037 746697006775 DinB superfamily; Region: DinB_2; pfam12867 746697006776 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 746697006777 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 746697006778 intracellular protease, PfpI family; Region: PfpI; TIGR01382 746697006779 proposed catalytic triad [active] 746697006780 conserved cys residue [active] 746697006781 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 746697006782 active site 746697006783 dimer interface [polypeptide binding]; other site 746697006784 metal binding site [ion binding]; metal-binding site 746697006785 Proline dehydrogenase; Region: Pro_dh; cl03282 746697006786 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 746697006787 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 746697006788 hexamer interface [polypeptide binding]; other site 746697006789 ligand binding site [chemical binding]; other site 746697006790 putative active site [active] 746697006791 NAD(P) binding site [chemical binding]; other site 746697006792 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 746697006793 Response regulator receiver domain; Region: Response_reg; pfam00072 746697006794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697006795 active site 746697006796 phosphorylation site [posttranslational modification] 746697006797 intermolecular recognition site; other site 746697006798 dimerization interface [polypeptide binding]; other site 746697006799 PglZ domain; Region: PglZ; pfam08665 746697006800 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 746697006801 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697006802 Zn2+ binding site [ion binding]; other site 746697006803 Mg2+ binding site [ion binding]; other site 746697006804 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 746697006805 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 746697006806 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 746697006807 trimer interface [polypeptide binding]; other site 746697006808 active site 746697006809 UDP-GlcNAc binding site [chemical binding]; other site 746697006810 lipid binding site [chemical binding]; lipid-binding site 746697006811 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 746697006812 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 746697006813 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 746697006814 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 746697006815 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 746697006816 active site 746697006817 elongation factor P; Validated; Region: PRK00529 746697006818 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 746697006819 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 746697006820 RNA binding site [nucleotide binding]; other site 746697006821 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 746697006822 RNA binding site [nucleotide binding]; other site 746697006823 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 746697006824 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 746697006825 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 746697006826 trimer interface [polypeptide binding]; other site 746697006827 active site 746697006828 UDP-GlcNAc binding site [chemical binding]; other site 746697006829 lipid binding site [chemical binding]; lipid-binding site 746697006830 SnoaL-like domain; Region: SnoaL_2; pfam12680 746697006831 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 746697006832 CoA binding domain; Region: CoA_binding; smart00881 746697006833 CoA-ligase; Region: Ligase_CoA; pfam00549 746697006834 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 746697006835 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 746697006836 NAD(P) binding site [chemical binding]; other site 746697006837 homotetramer interface [polypeptide binding]; other site 746697006838 homodimer interface [polypeptide binding]; other site 746697006839 active site 746697006840 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 746697006841 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 746697006842 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 746697006843 VPS10 domain; Region: VPS10; smart00602 746697006844 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 746697006845 Na binding site [ion binding]; other site 746697006846 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 746697006847 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 746697006848 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 746697006849 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 746697006850 histidinol dehydrogenase; Region: hisD; TIGR00069 746697006851 NAD binding site [chemical binding]; other site 746697006852 dimerization interface [polypeptide binding]; other site 746697006853 product binding site; other site 746697006854 substrate binding site [chemical binding]; other site 746697006855 zinc binding site [ion binding]; other site 746697006856 catalytic residues [active] 746697006857 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 746697006858 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 746697006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697006860 homodimer interface [polypeptide binding]; other site 746697006861 catalytic residue [active] 746697006862 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 746697006863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697006864 active site 746697006865 motif I; other site 746697006866 motif II; other site 746697006867 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 746697006868 putative active site pocket [active] 746697006869 4-fold oligomerization interface [polypeptide binding]; other site 746697006870 metal binding residues [ion binding]; metal-binding site 746697006871 3-fold/trimer interface [polypeptide binding]; other site 746697006872 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 746697006873 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 746697006874 putative active site [active] 746697006875 oxyanion strand; other site 746697006876 catalytic triad [active] 746697006877 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 746697006878 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 746697006879 catalytic residues [active] 746697006880 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 746697006881 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 746697006882 substrate binding site [chemical binding]; other site 746697006883 glutamase interaction surface [polypeptide binding]; other site 746697006884 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 746697006885 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 746697006886 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 746697006887 metal binding site [ion binding]; metal-binding site 746697006888 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 746697006889 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 746697006890 oligomer interface [polypeptide binding]; other site 746697006891 metal binding site [ion binding]; metal-binding site 746697006892 metal binding site [ion binding]; metal-binding site 746697006893 Cl binding site [ion binding]; other site 746697006894 aspartate ring; other site 746697006895 basic sphincter; other site 746697006896 putative hydrophobic gate; other site 746697006897 periplasmic entrance; other site 746697006898 methionine sulfoxide reductase A; Provisional; Region: PRK14054 746697006899 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 746697006900 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 746697006901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697006902 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 746697006903 FAD binding domain; Region: FAD_binding_4; pfam01565 746697006904 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cl01244 746697006905 Berberine and berberine like; Region: BBE; pfam08031 746697006906 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 746697006907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697006908 TPR motif; other site 746697006909 binding surface 746697006910 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 746697006911 Peptidase family M23; Region: Peptidase_M23; pfam01551 746697006912 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 746697006913 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 746697006914 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 746697006915 active site 746697006916 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 746697006917 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 746697006918 DNA-binding site [nucleotide binding]; DNA binding site 746697006919 RNA-binding motif; other site 746697006920 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 746697006921 thiamine phosphate binding site [chemical binding]; other site 746697006922 active site 746697006923 pyrophosphate binding site [ion binding]; other site 746697006924 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 746697006925 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 746697006926 ATP binding site [chemical binding]; other site 746697006927 putative Mg++ binding site [ion binding]; other site 746697006928 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 746697006929 Haem-binding domain; Region: Haem_bd; pfam14376 746697006930 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 746697006931 active site 746697006932 catalytic triad [active] 746697006933 oxyanion hole [active] 746697006934 switch loop; other site 746697006935 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 746697006936 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746697006937 Walker A/P-loop; other site 746697006938 ATP binding site [chemical binding]; other site 746697006939 Q-loop/lid; other site 746697006940 ABC transporter signature motif; other site 746697006941 Walker B; other site 746697006942 D-loop; other site 746697006943 H-loop/switch region; other site 746697006944 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 746697006945 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 746697006946 FtsX-like permease family; Region: FtsX; pfam02687 746697006947 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 746697006948 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 746697006949 potential catalytic triad [active] 746697006950 conserved cys residue [active] 746697006951 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 746697006952 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 746697006953 dimer interface [polypeptide binding]; other site 746697006954 active site 746697006955 metal binding site [ion binding]; metal-binding site 746697006956 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 746697006957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 746697006958 TIR domain; Region: TIR_2; pfam13676 746697006959 PGDYG protein; Region: PGDYG; pfam14083 746697006960 Caspase domain; Region: Peptidase_C14; pfam00656 746697006961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697006962 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697006963 binding surface 746697006964 TPR motif; other site 746697006965 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697006966 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 746697006967 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 746697006968 putative FMN binding site [chemical binding]; other site 746697006969 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 746697006970 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 746697006971 30S subunit binding site; other site 746697006972 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 746697006973 ArsC family; Region: ArsC; pfam03960 746697006974 acyl carrier protein; Provisional; Region: acpP; PRK00982 746697006975 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 746697006976 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 746697006977 dimer interface [polypeptide binding]; other site 746697006978 active site 746697006979 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 746697006980 active site 2 [active] 746697006981 dimer interface [polypeptide binding]; other site 746697006982 active site 1 [active] 746697006983 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 746697006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697006985 active site 746697006986 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 746697006987 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 746697006988 malonyl-CoA binding site [chemical binding]; other site 746697006989 dimer interface [polypeptide binding]; other site 746697006990 active site 746697006991 product binding site; other site 746697006992 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746697006993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697006994 S-adenosylmethionine binding site [chemical binding]; other site 746697006995 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 746697006996 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 746697006997 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 746697006998 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 746697006999 ligand binding site [chemical binding]; other site 746697007000 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 746697007001 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 746697007002 tetramer interface [polypeptide binding]; other site 746697007003 TPP-binding site [chemical binding]; other site 746697007004 heterodimer interface [polypeptide binding]; other site 746697007005 phosphorylation loop region [posttranslational modification] 746697007006 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 746697007007 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 746697007008 alpha subunit interface [polypeptide binding]; other site 746697007009 TPP binding site [chemical binding]; other site 746697007010 heterodimer interface [polypeptide binding]; other site 746697007011 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746697007012 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 746697007013 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 746697007014 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 746697007015 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 746697007016 putative rRNA binding site [nucleotide binding]; other site 746697007017 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 746697007018 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 746697007019 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 746697007020 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 746697007021 ligand binding site [chemical binding]; other site 746697007022 active site 746697007023 UGI interface [polypeptide binding]; other site 746697007024 catalytic site [active] 746697007025 MutS domain III; Region: MutS_III; pfam05192 746697007026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697007027 Walker A/P-loop; other site 746697007028 ATP binding site [chemical binding]; other site 746697007029 Q-loop/lid; other site 746697007030 ABC transporter signature motif; other site 746697007031 Walker B; other site 746697007032 D-loop; other site 746697007033 H-loop/switch region; other site 746697007034 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 746697007035 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 746697007036 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 746697007037 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697007038 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697007039 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 746697007040 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 746697007041 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 746697007042 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 746697007043 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 746697007044 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 746697007045 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 746697007046 Tetramer interface [polypeptide binding]; other site 746697007047 active site 746697007048 FMN-binding site [chemical binding]; other site 746697007049 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 746697007050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 746697007051 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 746697007052 amphipathic channel; other site 746697007053 Asn-Pro-Ala signature motifs; other site 746697007054 Domain of unknown function (DUF336); Region: DUF336; pfam03928 746697007055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697007056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 746697007057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 746697007058 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 746697007059 FAD binding domain; Region: FAD_binding_4; pfam01565 746697007060 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 746697007061 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 746697007062 active site 746697007063 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 746697007064 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 746697007065 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 746697007066 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 746697007067 Beta-lactamase; Region: Beta-lactamase; cl17358 746697007068 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746697007069 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 746697007070 Cysteine-rich domain; Region: CCG; pfam02754 746697007071 Cysteine-rich domain; Region: CCG; pfam02754 746697007072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697007073 active site 746697007074 motif I; other site 746697007075 motif II; other site 746697007076 4Fe-4S binding domain; Region: Fer4; cl02805 746697007077 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 746697007078 mce related protein; Region: MCE; pfam02470 746697007079 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 746697007080 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 746697007081 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 746697007082 active site 746697007083 metal binding site [ion binding]; metal-binding site 746697007084 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 746697007085 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 746697007086 homotrimer interaction site [polypeptide binding]; other site 746697007087 putative active site [active] 746697007088 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 746697007089 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746697007090 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697007091 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 746697007092 active site clefts [active] 746697007093 zinc binding site [ion binding]; other site 746697007094 dimer interface [polypeptide binding]; other site 746697007095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 746697007096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697007097 active site 746697007098 phosphorylation site [posttranslational modification] 746697007099 intermolecular recognition site; other site 746697007100 dimerization interface [polypeptide binding]; other site 746697007101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 746697007102 DNA binding residues [nucleotide binding] 746697007103 dimerization interface [polypeptide binding]; other site 746697007104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697007105 binding surface 746697007106 TPR motif; other site 746697007107 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697007108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697007109 TPR motif; other site 746697007110 binding surface 746697007111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697007112 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697007113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697007114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697007115 ATP binding site [chemical binding]; other site 746697007116 Mg2+ binding site [ion binding]; other site 746697007117 G-X-G motif; other site 746697007118 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 746697007119 EamA-like transporter family; Region: EamA; pfam00892 746697007120 EamA-like transporter family; Region: EamA; pfam00892 746697007121 TIR domain; Region: TIR_2; pfam13676 746697007122 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 746697007123 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 746697007124 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 746697007125 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 746697007126 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 746697007127 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 746697007128 active site 746697007129 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 746697007130 active site 746697007131 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 746697007132 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 746697007133 RNA binding site [nucleotide binding]; other site 746697007134 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 746697007135 RNA binding site [nucleotide binding]; other site 746697007136 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746697007137 RNA binding site [nucleotide binding]; other site 746697007138 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746697007139 RNA binding site [nucleotide binding]; other site 746697007140 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 746697007141 RNA binding site [nucleotide binding]; other site 746697007142 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 746697007143 RNA binding site [nucleotide binding]; other site 746697007144 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 746697007145 META domain; Region: META; pfam03724 746697007146 DNA topoisomerase IV subunit A; Provisional; Region: PRK12758 746697007147 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 746697007148 CAP-like domain; other site 746697007149 active site 746697007150 primary dimer interface [polypeptide binding]; other site 746697007151 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 746697007152 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 746697007153 ATP binding site [chemical binding]; other site 746697007154 Mg2+ binding site [ion binding]; other site 746697007155 G-X-G motif; other site 746697007156 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 746697007157 anchoring element; other site 746697007158 dimer interface [polypeptide binding]; other site 746697007159 ATP binding site [chemical binding]; other site 746697007160 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 746697007161 active site 746697007162 putative metal-binding site [ion binding]; other site 746697007163 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 746697007164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 746697007165 HSP70 interaction site [polypeptide binding]; other site 746697007166 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 746697007167 substrate binding site [polypeptide binding]; other site 746697007168 dimer interface [polypeptide binding]; other site 746697007169 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 746697007170 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 746697007171 active site 746697007172 GTP-binding protein YchF; Reviewed; Region: PRK09601 746697007173 YchF GTPase; Region: YchF; cd01900 746697007174 G1 box; other site 746697007175 GTP/Mg2+ binding site [chemical binding]; other site 746697007176 Switch I region; other site 746697007177 G2 box; other site 746697007178 Switch II region; other site 746697007179 G3 box; other site 746697007180 G4 box; other site 746697007181 G5 box; other site 746697007182 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 746697007183 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697007184 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697007185 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697007186 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 746697007187 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007188 4Fe-4S binding domain; Region: Fer4; cl02805 746697007189 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 746697007190 NAD(P) binding site [chemical binding]; other site 746697007191 catalytic residues [active] 746697007192 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 746697007193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697007194 catalytic residue [active] 746697007195 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 746697007196 Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303 746697007197 putative ligand binding site [chemical binding]; other site 746697007198 NAD binding site [chemical binding]; other site 746697007199 dimerization interface [polypeptide binding]; other site 746697007200 catalytic site [active] 746697007201 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 746697007202 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697007203 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697007204 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697007205 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 746697007206 GTP cyclohydrolase I; Provisional; Region: PLN03044 746697007207 homodecamer interface [polypeptide binding]; other site 746697007208 active site 746697007209 putative catalytic site residues [active] 746697007210 zinc binding site [ion binding]; other site 746697007211 GTP-CH-I/GFRP interaction surface; other site 746697007212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 746697007213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 746697007214 Walker A/P-loop; other site 746697007215 ATP binding site [chemical binding]; other site 746697007216 Q-loop/lid; other site 746697007217 ABC transporter signature motif; other site 746697007218 Walker B; other site 746697007219 D-loop; other site 746697007220 H-loop/switch region; other site 746697007221 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 746697007222 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 746697007223 GAF domain; Region: GAF; pfam01590 746697007224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697007225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697007226 dimer interface [polypeptide binding]; other site 746697007227 phosphorylation site [posttranslational modification] 746697007228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697007229 ATP binding site [chemical binding]; other site 746697007230 Mg2+ binding site [ion binding]; other site 746697007231 G-X-G motif; other site 746697007232 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 746697007233 von Willebrand factor type A domain; Region: VWA_2; pfam13519 746697007234 dihydroorotase; Validated; Region: pyrC; PRK09357 746697007235 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 746697007236 active site 746697007237 Predicted esterase [General function prediction only]; Region: COG0400 746697007238 putative hydrolase; Provisional; Region: PRK11460 746697007239 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 746697007240 putative hydrolase; Provisional; Region: PRK02113 746697007241 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 746697007242 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 746697007243 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 746697007244 catalytic triad [active] 746697007245 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 746697007246 endonuclease III; Region: ENDO3c; smart00478 746697007247 minor groove reading motif; other site 746697007248 helix-hairpin-helix signature motif; other site 746697007249 substrate binding pocket [chemical binding]; other site 746697007250 active site 746697007251 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697007252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697007253 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697007254 DNA binding residues [nucleotide binding] 746697007255 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 746697007256 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 746697007257 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 746697007258 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 746697007259 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 746697007260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697007261 Predicted membrane protein [Function unknown]; Region: COG4485 746697007262 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 746697007263 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 746697007264 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 746697007265 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697007266 catalytic residue [active] 746697007267 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 746697007268 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 746697007269 dimer interface [polypeptide binding]; other site 746697007270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007271 catalytic residue [active] 746697007272 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 746697007273 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697007274 hypothetical protein; Provisional; Region: PRK14623 746697007275 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 746697007276 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 746697007277 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 746697007278 tetramer interface [polypeptide binding]; other site 746697007279 TPP-binding site [chemical binding]; other site 746697007280 heterodimer interface [polypeptide binding]; other site 746697007281 phosphorylation loop region [posttranslational modification] 746697007282 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 746697007283 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 746697007284 PYR/PP interface [polypeptide binding]; other site 746697007285 dimer interface [polypeptide binding]; other site 746697007286 TPP binding site [chemical binding]; other site 746697007287 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 746697007288 Family of unknown function (DUF490); Region: DUF490; pfam04357 746697007289 Family of unknown function (DUF490); Region: DUF490; pfam04357 746697007290 UGMP family protein; Validated; Region: PRK09604 746697007291 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 746697007292 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 746697007293 RNA methyltransferase, RsmE family; Region: TIGR00046 746697007294 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 746697007295 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 746697007296 Domain of unknown function DUF20; Region: UPF0118; pfam01594 746697007297 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 746697007298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 746697007299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 746697007300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 746697007301 dimerization interface [polypeptide binding]; other site 746697007302 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 746697007303 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 746697007304 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 746697007305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 746697007306 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 746697007307 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 746697007308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697007309 Zn2+ binding site [ion binding]; other site 746697007310 Mg2+ binding site [ion binding]; other site 746697007311 acetyl-CoA C-acetyltransferase; Region: PLN02644 746697007312 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 746697007313 dimer interface [polypeptide binding]; other site 746697007314 active site 746697007315 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 746697007316 NlpC/P60 family; Region: NLPC_P60; pfam00877 746697007317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697007318 binding surface 746697007319 TPR motif; other site 746697007320 TPR repeat; Region: TPR_11; pfam13414 746697007321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697007322 binding surface 746697007323 TPR motif; other site 746697007324 DNA gyrase subunit A; Validated; Region: PRK05560 746697007325 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 746697007326 CAP-like domain; other site 746697007327 active site 746697007328 primary dimer interface [polypeptide binding]; other site 746697007329 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746697007330 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746697007331 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746697007332 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746697007333 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746697007334 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 746697007335 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 746697007336 Clp amino terminal domain; Region: Clp_N; pfam02861 746697007337 Clp amino terminal domain; Region: Clp_N; pfam02861 746697007338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697007339 Walker A motif; other site 746697007340 ATP binding site [chemical binding]; other site 746697007341 Walker B motif; other site 746697007342 arginine finger; other site 746697007343 UvrB/uvrC motif; Region: UVR; pfam02151 746697007344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697007345 Walker A motif; other site 746697007346 ATP binding site [chemical binding]; other site 746697007347 Walker B motif; other site 746697007348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 746697007349 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007350 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 746697007351 active sites [active] 746697007352 tetramer interface [polypeptide binding]; other site 746697007353 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697007354 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697007355 catalytic residues [active] 746697007356 Smr domain; Region: Smr; pfam01713 746697007357 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007358 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 746697007359 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 746697007360 inhibitor-cofactor binding pocket; inhibition site 746697007361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007362 catalytic residue [active] 746697007363 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 746697007364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697007365 S-adenosylmethionine binding site [chemical binding]; other site 746697007366 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 746697007367 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 746697007368 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 746697007369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697007370 Methyltransferase domain; Region: Methyltransf_31; pfam13847 746697007371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697007372 S-adenosylmethionine binding site [chemical binding]; other site 746697007373 PIF1-like helicase; Region: PIF1; pfam05970 746697007374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 746697007375 Walker A motif; other site 746697007376 ATP binding site [chemical binding]; other site 746697007377 Walker B motif; other site 746697007378 Family description; Region: UvrD_C_2; pfam13538 746697007379 HRDC domain; Region: HRDC; pfam00570 746697007380 Domain of unknown function (DUF4294); Region: DUF4294; pfam14127 746697007381 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 746697007382 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 746697007383 oligomer interface [polypeptide binding]; other site 746697007384 active site 746697007385 metal binding site [ion binding]; metal-binding site 746697007386 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 746697007387 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 746697007388 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 746697007389 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 746697007390 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007391 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 746697007392 ATP binding site [chemical binding]; other site 746697007393 active site 746697007394 substrate binding site [chemical binding]; other site 746697007395 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 746697007396 PhoH-like protein; Region: PhoH; pfam02562 746697007397 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 746697007398 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 746697007399 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 746697007400 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 746697007401 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 746697007402 DNA polymerase III subunit beta; Validated; Region: PRK05643 746697007403 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 746697007404 putative DNA binding surface [nucleotide binding]; other site 746697007405 dimer interface [polypeptide binding]; other site 746697007406 beta-clamp/clamp loader binding surface; other site 746697007407 beta-clamp/translesion DNA polymerase binding surface; other site 746697007408 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 746697007409 Uncharacterized conserved protein [Function unknown]; Region: COG3391 746697007410 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007411 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 746697007412 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 746697007413 trmE is a tRNA modification GTPase; Region: trmE; cd04164 746697007414 G1 box; other site 746697007415 GTP/Mg2+ binding site [chemical binding]; other site 746697007416 Switch I region; other site 746697007417 G2 box; other site 746697007418 Switch II region; other site 746697007419 G3 box; other site 746697007420 G4 box; other site 746697007421 G5 box; other site 746697007422 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 746697007423 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 746697007424 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 746697007425 Domain of unknown function (DUF427); Region: DUF427; pfam04248 746697007426 methionine sulfoxide reductase A; Provisional; Region: PRK14054 746697007427 Predicted acetyltransferase [General function prediction only]; Region: COG2388 746697007428 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697007429 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 746697007430 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 746697007431 NAD(P) binding site [chemical binding]; other site 746697007432 catalytic residues [active] 746697007433 biotin carboxylase-like protein; Validated; Region: PRK06524 746697007434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697007435 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 746697007436 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 746697007437 homodimer interface [polypeptide binding]; other site 746697007438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007439 catalytic residue [active] 746697007440 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 746697007441 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697007442 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 746697007443 Predicted amidohydrolase [General function prediction only]; Region: COG0388 746697007444 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 746697007445 active site 746697007446 catalytic triad [active] 746697007447 dimer interface [polypeptide binding]; other site 746697007448 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 746697007449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 746697007450 inhibitor-cofactor binding pocket; inhibition site 746697007451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007452 catalytic residue [active] 746697007453 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 746697007454 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 746697007455 nucleophilic elbow; other site 746697007456 catalytic triad; other site 746697007457 CHAT domain; Region: CHAT; pfam12770 746697007458 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 746697007459 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 746697007460 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 746697007461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 746697007462 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 746697007463 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 746697007464 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 746697007465 N-terminal plug; other site 746697007466 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 746697007467 ligand-binding site [chemical binding]; other site 746697007468 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 746697007469 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 746697007470 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 746697007471 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 746697007472 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 746697007473 Chain length determinant protein; Region: Wzz; cl15801 746697007474 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 746697007475 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 746697007476 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 746697007477 Nucleotide binding site [chemical binding]; other site 746697007478 P loop; other site 746697007479 DTAP/Switch II; other site 746697007480 Switch I; other site 746697007481 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 746697007482 SLBB domain; Region: SLBB; pfam10531 746697007483 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 746697007484 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 746697007485 NAD(P) binding site [chemical binding]; other site 746697007486 homodimer interface [polypeptide binding]; other site 746697007487 substrate binding site [chemical binding]; other site 746697007488 active site 746697007489 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 746697007490 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 746697007491 inhibitor-cofactor binding pocket; inhibition site 746697007492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007493 catalytic residue [active] 746697007494 Bacterial sugar transferase; Region: Bac_transf; pfam02397 746697007495 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 746697007496 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 746697007497 putative trimer interface [polypeptide binding]; other site 746697007498 putative CoA binding site [chemical binding]; other site 746697007499 Bacterial sugar transferase; Region: Bac_transf; pfam02397 746697007500 AAA domain; Region: AAA_14; pfam13173 746697007501 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 746697007502 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 746697007503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697007504 putative ADP-binding pocket [chemical binding]; other site 746697007505 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697007506 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 746697007507 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697007508 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 746697007509 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 746697007510 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 746697007511 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 746697007512 active site 746697007513 dimer interface [polypeptide binding]; other site 746697007514 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 746697007515 Ligand Binding Site [chemical binding]; other site 746697007516 Molecular Tunnel; other site 746697007517 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 746697007518 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 746697007519 putative ADP-binding pocket [chemical binding]; other site 746697007520 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 746697007521 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 746697007522 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 746697007523 trimer interface [polypeptide binding]; other site 746697007524 active site 746697007525 substrate binding site [chemical binding]; other site 746697007526 CoA binding site [chemical binding]; other site 746697007527 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 746697007528 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 746697007529 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 746697007530 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 746697007531 trimer interface [polypeptide binding]; other site 746697007532 active site 746697007533 substrate binding site [chemical binding]; other site 746697007534 CoA binding site [chemical binding]; other site 746697007535 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 746697007536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697007537 active site 746697007538 motif I; other site 746697007539 motif II; other site 746697007540 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 746697007541 NeuB family; Region: NeuB; pfam03102 746697007542 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 746697007543 NeuB binding interface [polypeptide binding]; other site 746697007544 putative substrate binding site [chemical binding]; other site 746697007545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697007546 active site 746697007547 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 746697007548 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 746697007549 substrate binding site; other site 746697007550 tetramer interface; other site 746697007551 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 746697007552 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 746697007553 NADP binding site [chemical binding]; other site 746697007554 active site 746697007555 putative substrate binding site [chemical binding]; other site 746697007556 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 746697007557 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 746697007558 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 746697007559 NAD binding site [chemical binding]; other site 746697007560 substrate binding site [chemical binding]; other site 746697007561 homodimer interface [polypeptide binding]; other site 746697007562 active site 746697007563 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 746697007564 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 746697007565 substrate binding site; other site 746697007566 tetramer interface; other site 746697007567 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 746697007568 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 746697007569 NADP binding site [chemical binding]; other site 746697007570 active site 746697007571 putative substrate binding site [chemical binding]; other site 746697007572 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 746697007573 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 746697007574 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 746697007575 NAD binding site [chemical binding]; other site 746697007576 substrate binding site [chemical binding]; other site 746697007577 homodimer interface [polypeptide binding]; other site 746697007578 active site 746697007579 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 746697007580 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 746697007581 CysD dimerization site [polypeptide binding]; other site 746697007582 G1 box; other site 746697007583 putative GEF interaction site [polypeptide binding]; other site 746697007584 GTP/Mg2+ binding site [chemical binding]; other site 746697007585 Switch I region; other site 746697007586 G2 box; other site 746697007587 G3 box; other site 746697007588 Switch II region; other site 746697007589 G4 box; other site 746697007590 G5 box; other site 746697007591 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 746697007592 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 746697007593 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 746697007594 four helix bundle protein; Region: TIGR02436 746697007595 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 746697007596 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 746697007597 Active Sites [active] 746697007598 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 746697007599 four helix bundle protein; Region: TIGR02436 746697007600 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 746697007601 ligand-binding site [chemical binding]; other site 746697007602 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 746697007603 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 746697007604 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 746697007605 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 746697007606 active site 746697007607 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 746697007608 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 746697007609 dimerization interface [polypeptide binding]; other site 746697007610 DPS ferroxidase diiron center [ion binding]; other site 746697007611 ion pore; other site 746697007612 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 746697007613 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 746697007614 active site 746697007615 metal binding site [ion binding]; metal-binding site 746697007616 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697007617 Surface antigen; Region: Bac_surface_Ag; pfam01103 746697007618 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 746697007619 Zn2+ binding site [ion binding]; other site 746697007620 Mg2+ binding site [ion binding]; other site 746697007621 Domain of unknown function (DUF4369); Region: DUF4369; pfam14289 746697007622 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697007623 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697007624 catalytic residues [active] 746697007625 Uncharacterized conserved protein [Function unknown]; Region: COG2968 746697007626 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 746697007627 Rhomboid family; Region: Rhomboid; cl11446 746697007628 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 746697007629 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 746697007630 putative acyl-acceptor binding pocket; other site 746697007631 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007632 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 746697007633 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 746697007634 active site 746697007635 substrate binding site [chemical binding]; other site 746697007636 metal binding site [ion binding]; metal-binding site 746697007637 Acyltransferase family; Region: Acyl_transf_3; pfam01757 746697007638 Protein of unknown function, DUF479; Region: DUF479; cl01203 746697007639 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 746697007640 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 746697007641 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 746697007642 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 746697007643 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 746697007644 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 746697007645 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 746697007646 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697007647 putative catalytic site [active] 746697007648 putative metal binding site [ion binding]; other site 746697007649 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 746697007650 putative catalytic site [active] 746697007651 putative phosphate binding site [ion binding]; other site 746697007652 putative phosphate binding site [ion binding]; other site 746697007653 putative metal binding site [ion binding]; other site 746697007654 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007655 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 746697007656 Zn binding site [ion binding]; other site 746697007657 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 746697007658 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 746697007659 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 746697007660 active site 746697007661 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 746697007662 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 746697007663 tetramer interface [polypeptide binding]; other site 746697007664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007665 catalytic residue [active] 746697007666 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 746697007667 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 746697007668 Domain of unknown function (DUF4249); Region: DUF4249; pfam14054 746697007669 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697007670 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697007671 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697007672 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697007673 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 746697007674 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 746697007675 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 746697007676 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 746697007677 ArsC family; Region: ArsC; pfam03960 746697007678 catalytic residues [active] 746697007679 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697007680 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 746697007681 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697007682 fumarate hydratase; Reviewed; Region: fumC; PRK00485 746697007683 Class II fumarases; Region: Fumarase_classII; cd01362 746697007684 active site 746697007685 tetramer interface [polypeptide binding]; other site 746697007686 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 746697007687 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 746697007688 Na binding site [ion binding]; other site 746697007689 PIN domain; Region: PIN_3; cl17397 746697007690 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 746697007691 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 746697007692 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 746697007693 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 746697007694 Mechanosensitive ion channel; Region: MS_channel; pfam00924 746697007695 Maf-like protein; Region: Maf; pfam02545 746697007696 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 746697007697 active site 746697007698 dimer interface [polypeptide binding]; other site 746697007699 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 746697007700 UbiA prenyltransferase family; Region: UbiA; pfam01040 746697007701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 746697007702 active site 746697007703 motif I; other site 746697007704 motif II; other site 746697007705 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 746697007706 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 746697007707 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 746697007708 ligand binding site [chemical binding]; other site 746697007709 flexible hinge region; other site 746697007710 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 746697007711 putative switch regulator; other site 746697007712 non-specific DNA interactions [nucleotide binding]; other site 746697007713 DNA binding site [nucleotide binding] 746697007714 sequence specific DNA binding site [nucleotide binding]; other site 746697007715 putative cAMP binding site [chemical binding]; other site 746697007716 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 746697007717 heme-binding site [chemical binding]; other site 746697007718 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 746697007719 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 746697007720 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 746697007721 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 746697007722 Domain of unknown function (DUF4252); Region: DUF4252; pfam14060 746697007723 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697007724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697007725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697007726 DNA binding residues [nucleotide binding] 746697007727 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 746697007728 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 746697007729 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 746697007730 Catalytic dyad [active] 746697007731 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 746697007732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 746697007733 PAS domain; Region: PAS_9; pfam13426 746697007734 putative active site [active] 746697007735 heme pocket [chemical binding]; other site 746697007736 Uncharacterized conserved protein [Function unknown]; Region: COG3391 746697007737 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 746697007738 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 746697007739 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 746697007740 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 746697007741 putative ligand binding site [chemical binding]; other site 746697007742 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 746697007743 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 746697007744 ABC-ATPase subunit interface; other site 746697007745 dimer interface [polypeptide binding]; other site 746697007746 putative PBP binding regions; other site 746697007747 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 746697007748 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 746697007749 Walker A/P-loop; other site 746697007750 ATP binding site [chemical binding]; other site 746697007751 Q-loop/lid; other site 746697007752 ABC transporter signature motif; other site 746697007753 Walker B; other site 746697007754 D-loop; other site 746697007755 H-loop/switch region; other site 746697007756 RmuC family; Region: RmuC; pfam02646 746697007757 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 746697007758 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 746697007759 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 746697007760 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007761 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746697007762 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 746697007763 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697007764 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 746697007765 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 746697007766 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 746697007767 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 746697007768 ATP-grasp domain; Region: ATP-grasp_4; cl17255 746697007769 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 746697007770 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697007771 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697007772 catalytic residues [active] 746697007773 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 746697007774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 746697007775 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 746697007776 Predicted acetyltransferase [General function prediction only]; Region: COG2388 746697007777 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 746697007778 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 746697007779 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 746697007780 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 746697007781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697007782 S-adenosylmethionine binding site [chemical binding]; other site 746697007783 Endonuclease I; Region: Endonuclease_1; cl01003 746697007784 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697007785 Uncharacterized conserved protein [Function unknown]; Region: COG1572 746697007786 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 746697007787 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 746697007788 dimerization interface [polypeptide binding]; other site 746697007789 ATP binding site [chemical binding]; other site 746697007790 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 746697007791 dimerization interface [polypeptide binding]; other site 746697007792 ATP binding site [chemical binding]; other site 746697007793 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 746697007794 putative active site [active] 746697007795 catalytic triad [active] 746697007796 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 746697007797 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746697007798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 746697007799 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 746697007800 acyl-activating enzyme (AAE) consensus motif; other site 746697007801 acyl-activating enzyme (AAE) consensus motif; other site 746697007802 putative AMP binding site [chemical binding]; other site 746697007803 putative active site [active] 746697007804 putative CoA binding site [chemical binding]; other site 746697007805 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 746697007806 active site 746697007807 NTP binding site [chemical binding]; other site 746697007808 metal binding triad [ion binding]; metal-binding site 746697007809 antibiotic binding site [chemical binding]; other site 746697007810 Uncharacterized conserved protein [Function unknown]; Region: COG2361 746697007811 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 746697007812 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 746697007813 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 746697007814 Ligand binding site; other site 746697007815 Putative Catalytic site; other site 746697007816 DXD motif; other site 746697007817 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 746697007818 Protein of unknown function, DUF488; Region: DUF488; pfam04343 746697007819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 746697007820 MarR family; Region: MarR; pfam01047 746697007821 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 746697007822 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 746697007823 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 746697007824 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 746697007825 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 746697007826 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 746697007827 substrate binding site [chemical binding]; other site 746697007828 oxyanion hole (OAH) forming residues; other site 746697007829 trimer interface [polypeptide binding]; other site 746697007830 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 746697007831 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 746697007832 dimer interface [polypeptide binding]; other site 746697007833 active site 746697007834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 746697007835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 746697007836 active site 746697007837 MG2 domain; Region: A2M_N; pfam01835 746697007838 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 746697007839 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 746697007840 putative metal binding site [ion binding]; other site 746697007841 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 746697007842 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 746697007843 Peptidase family M1; Region: Peptidase_M1; pfam01433 746697007844 Zn binding site [ion binding]; other site 746697007845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 746697007846 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 746697007847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697007848 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 746697007849 Walker A/P-loop; other site 746697007850 ATP binding site [chemical binding]; other site 746697007851 Q-loop/lid; other site 746697007852 ABC transporter signature motif; other site 746697007853 Walker B; other site 746697007854 D-loop; other site 746697007855 H-loop/switch region; other site 746697007856 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 746697007857 Fasciclin domain; Region: Fasciclin; pfam02469 746697007858 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 746697007859 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 746697007860 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 746697007861 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 746697007862 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 746697007863 metal ion-dependent adhesion site (MIDAS); other site 746697007864 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 746697007865 putative proton transfer pathway, P2; other site 746697007866 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 746697007867 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697007868 Uncharacterized conserved protein [Function unknown]; Region: COG4850 746697007869 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 746697007870 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 746697007871 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 746697007872 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697007873 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 746697007874 OsmC-like protein; Region: OsmC; pfam02566 746697007875 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 746697007876 E-class dimer interface [polypeptide binding]; other site 746697007877 P-class dimer interface [polypeptide binding]; other site 746697007878 active site 746697007879 Cu2+ binding site [ion binding]; other site 746697007880 Zn2+ binding site [ion binding]; other site 746697007881 TraB family; Region: TraB; pfam01963 746697007882 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 746697007883 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 746697007884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 746697007885 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 746697007886 Peptidase family S41; Region: Peptidase_S41; pfam03572 746697007887 Active site serine [active] 746697007888 methionine gamma-lyase; Region: PLN02242 746697007889 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 746697007890 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 746697007891 catalytic residue [active] 746697007892 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 746697007893 trimer interface [polypeptide binding]; other site 746697007894 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 746697007895 trimer interface [polypeptide binding]; other site 746697007896 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 746697007897 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 746697007898 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 746697007899 dimer interface [polypeptide binding]; other site 746697007900 decamer (pentamer of dimers) interface [polypeptide binding]; other site 746697007901 catalytic triad [active] 746697007902 peroxidatic and resolving cysteines [active] 746697007903 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 746697007904 catalytic residues [active] 746697007905 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 746697007906 dimer interface [polypeptide binding]; other site 746697007907 catalytic triad [active] 746697007908 peroxidatic and resolving cysteines [active] 746697007909 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 746697007910 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 746697007911 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 746697007912 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 746697007913 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 746697007914 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 746697007915 Predicted permeases [General function prediction only]; Region: COG0795 746697007916 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 746697007917 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 746697007918 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 746697007919 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 746697007920 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 746697007921 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 746697007922 dimerization interface [polypeptide binding]; other site 746697007923 active site 746697007924 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 746697007925 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 746697007926 inhibitor-cofactor binding pocket; inhibition site 746697007927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 746697007928 catalytic residue [active] 746697007929 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 746697007930 dimer interface [polypeptide binding]; other site 746697007931 FMN binding site [chemical binding]; other site 746697007932 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 746697007933 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 746697007934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697007935 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697007936 dimer interface [polypeptide binding]; other site 746697007937 phosphorylation site [posttranslational modification] 746697007938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697007939 ATP binding site [chemical binding]; other site 746697007940 Mg2+ binding site [ion binding]; other site 746697007941 G-X-G motif; other site 746697007942 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 746697007943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697007944 active site 746697007945 phosphorylation site [posttranslational modification] 746697007946 intermolecular recognition site; other site 746697007947 dimerization interface [polypeptide binding]; other site 746697007948 Helix-turn-helix domain; Region: HTH_18; pfam12833 746697007949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697007950 RteC protein; Region: RteC; pfam09357 746697007951 LytTr DNA-binding domain; Region: LytTR; smart00850 746697007952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697007953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697007954 binding surface 746697007955 TPR motif; other site 746697007956 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697007957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 746697007958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 746697007959 Histidine kinase; Region: HisKA_3; pfam07730 746697007960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697007961 ATP binding site [chemical binding]; other site 746697007962 Mg2+ binding site [ion binding]; other site 746697007963 G-X-G motif; other site 746697007964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697007965 Response regulator receiver domain; Region: Response_reg; pfam00072 746697007966 active site 746697007967 phosphorylation site [posttranslational modification] 746697007968 intermolecular recognition site; other site 746697007969 dimerization interface [polypeptide binding]; other site 746697007970 Methylamine utilisation protein MauE; Region: MauE; pfam07291 746697007971 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 746697007972 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 746697007973 starch binding outer membrane protein SusD; Region: SusD; cd08977 746697007974 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697007975 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 746697007976 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 746697007977 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 746697007978 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 746697007979 FecR protein; Region: FecR; pfam04773 746697007980 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 746697007981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697007982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697007983 DNA binding residues [nucleotide binding] 746697007984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697007985 non-specific DNA binding site [nucleotide binding]; other site 746697007986 salt bridge; other site 746697007987 sequence-specific DNA binding site [nucleotide binding]; other site 746697007988 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 746697007989 TIGR02646 family protein; Region: TIGR02646 746697007990 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746697007991 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 746697007992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697007993 binding surface 746697007994 TPR motif; other site 746697007995 TPR repeat; Region: TPR_11; pfam13414 746697007996 HipA N-terminal domain; Region: Couple_hipA; pfam13657 746697007997 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 746697007998 HipA-like N-terminal domain; Region: HipA_N; pfam07805 746697007999 HipA-like C-terminal domain; Region: HipA_C; pfam07804 746697008000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746697008001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697008002 non-specific DNA binding site [nucleotide binding]; other site 746697008003 salt bridge; other site 746697008004 sequence-specific DNA binding site [nucleotide binding]; other site 746697008005 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 746697008006 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 746697008007 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008008 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 746697008009 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 746697008010 CsbD-like; Region: CsbD; pfam05532 746697008011 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 746697008012 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 746697008013 catalytic triad [active] 746697008014 putative active site [active] 746697008015 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008016 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 746697008017 Predicted membrane protein [Function unknown]; Region: COG2323 746697008018 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 746697008019 generic binding surface II; other site 746697008020 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 746697008021 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 746697008022 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 746697008023 active site 746697008024 DNA binding site [nucleotide binding] 746697008025 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 746697008026 DNA binding site [nucleotide binding] 746697008027 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 746697008028 nucleotide binding site [chemical binding]; other site 746697008029 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 746697008030 putative DNA binding site [nucleotide binding]; other site 746697008031 putative homodimer interface [polypeptide binding]; other site 746697008032 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 746697008033 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 746697008034 active site 746697008035 DNA binding site [nucleotide binding] 746697008036 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 746697008037 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 746697008038 active site 746697008039 PHP Thumb interface [polypeptide binding]; other site 746697008040 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 746697008041 generic binding surface II; other site 746697008042 generic binding surface I; other site 746697008043 Protein kinase domain; Region: Pkinase; pfam00069 746697008044 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 746697008045 active site 746697008046 ATP binding site [chemical binding]; other site 746697008047 substrate binding site [chemical binding]; other site 746697008048 activation loop (A-loop); other site 746697008049 Methyltransferase domain; Region: Methyltransf_26; pfam13659 746697008050 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 746697008051 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 746697008052 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 746697008053 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 746697008054 GIY-YIG motif/motif A; other site 746697008055 active site 746697008056 catalytic site [active] 746697008057 putative DNA binding site [nucleotide binding]; other site 746697008058 metal binding site [ion binding]; metal-binding site 746697008059 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 746697008060 Part of AAA domain; Region: AAA_19; pfam13245 746697008061 Family description; Region: UvrD_C_2; pfam13538 746697008062 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 746697008063 Uncharacterized conserved protein [Function unknown]; Region: COG4095 746697008064 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 746697008065 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 746697008066 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 746697008067 hydroperoxidase II; Provisional; Region: katE; PRK11249 746697008068 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 746697008069 tetramer interface [polypeptide binding]; other site 746697008070 heme binding pocket [chemical binding]; other site 746697008071 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 746697008072 domain interactions; other site 746697008073 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 746697008074 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 746697008075 dimer interface [polypeptide binding]; other site 746697008076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697008077 cryptochrome, DASH family; Region: crypto_DASH; TIGR02765 746697008078 DNA photolyase; Region: DNA_photolyase; pfam00875 746697008079 Predicted membrane protein [Function unknown]; Region: COG2323 746697008080 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 746697008081 dimerization interface [polypeptide binding]; other site 746697008082 metal binding site [ion binding]; metal-binding site 746697008083 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 746697008084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 746697008085 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 746697008086 Predicted transcriptional regulator [Transcription]; Region: COG5340 746697008087 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 746697008088 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 746697008089 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 746697008090 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 746697008091 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 746697008092 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 746697008093 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 746697008094 Walker A/P-loop; other site 746697008095 ATP binding site [chemical binding]; other site 746697008096 Q-loop/lid; other site 746697008097 ABC transporter signature motif; other site 746697008098 Walker B; other site 746697008099 D-loop; other site 746697008100 H-loop/switch region; other site 746697008101 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 746697008102 Uncharacterized conserved protein [Function unknown]; Region: COG2898 746697008103 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746697008104 Beta-lactamase; Region: Beta-lactamase; pfam00144 746697008105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 746697008106 TPR repeat; Region: TPR_11; pfam13414 746697008107 binding surface 746697008108 TPR motif; other site 746697008109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 746697008110 Beta-lactamase; Region: Beta-lactamase; pfam00144 746697008111 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 746697008112 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 746697008113 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 746697008114 Walker A/P-loop; other site 746697008115 ATP binding site [chemical binding]; other site 746697008116 Q-loop/lid; other site 746697008117 ABC transporter signature motif; other site 746697008118 Walker B; other site 746697008119 D-loop; other site 746697008120 H-loop/switch region; other site 746697008121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 746697008122 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 746697008123 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 746697008124 active site 746697008125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 746697008126 AAA domain; Region: AAA_33; pfam13671 746697008127 AAA domain; Region: AAA_17; pfam13207 746697008128 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 746697008129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697008130 Coenzyme A binding pocket [chemical binding]; other site 746697008131 LytTr DNA-binding domain; Region: LytTR; smart00850 746697008132 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cd00421 746697008133 active site 746697008134 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 746697008135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697008136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697008137 DNA binding residues [nucleotide binding] 746697008138 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 746697008139 Active site serine [active] 746697008140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 746697008141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 746697008142 non-specific DNA binding site [nucleotide binding]; other site 746697008143 salt bridge; other site 746697008144 sequence-specific DNA binding site [nucleotide binding]; other site 746697008145 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 746697008146 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 746697008147 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 746697008148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 746697008149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 746697008150 DNA binding residues [nucleotide binding] 746697008151 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 746697008152 metal-binding site [ion binding] 746697008153 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 746697008154 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697008155 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 746697008156 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 746697008157 Domain of unknown function (DUF305); Region: DUF305; cl17794 746697008158 Predicted permease; Region: DUF318; cl17795 746697008159 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 746697008160 Haem-binding domain; Region: Haem_bd; pfam14376 746697008161 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 746697008162 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 746697008163 Multicopper oxidase; Region: Cu-oxidase; pfam00394 746697008164 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 746697008165 Outer membrane efflux protein; Region: OEP; pfam02321 746697008166 Outer membrane efflux protein; Region: OEP; pfam02321 746697008167 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 746697008168 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 746697008169 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 746697008170 lipid A phosphoethanolamine transferase; Reviewed; Region: PRK09598 746697008171 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 746697008172 Sulfatase; Region: Sulfatase; pfam00884 746697008173 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 746697008174 active site 746697008175 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 746697008176 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 746697008177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697008178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697008179 dimer interface [polypeptide binding]; other site 746697008180 phosphorylation site [posttranslational modification] 746697008181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697008182 ATP binding site [chemical binding]; other site 746697008183 Mg2+ binding site [ion binding]; other site 746697008184 G-X-G motif; other site 746697008185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746697008186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697008187 active site 746697008188 phosphorylation site [posttranslational modification] 746697008189 intermolecular recognition site; other site 746697008190 dimerization interface [polypeptide binding]; other site 746697008191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746697008192 DNA binding site [nucleotide binding] 746697008193 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697008194 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697008195 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 746697008196 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 746697008197 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 746697008198 HlyD family secretion protein; Region: HlyD_3; pfam13437 746697008199 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 746697008200 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 746697008201 acetyl-CoA synthetase; Provisional; Region: PRK00174 746697008202 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 746697008203 active site 746697008204 CoA binding site [chemical binding]; other site 746697008205 acyl-activating enzyme (AAE) consensus motif; other site 746697008206 AMP binding site [chemical binding]; other site 746697008207 acetate binding site [chemical binding]; other site 746697008208 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 746697008209 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 746697008210 catalytic residues [active] 746697008211 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008212 CsbD-like; Region: CsbD; pfam05532 746697008213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 746697008214 catalytic core [active] 746697008215 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 746697008216 SmpB-tmRNA interface; other site 746697008217 Cna protein B-type domain; Region: Cna_B_2; pfam13715 746697008218 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 746697008219 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 746697008220 putative hydrophobic ligand binding site [chemical binding]; other site 746697008221 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 746697008222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697008223 Coenzyme A binding pocket [chemical binding]; other site 746697008224 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 746697008225 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 746697008226 Methyltransferase domain; Region: Methyltransf_18; pfam12847 746697008227 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 746697008228 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 746697008229 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 746697008230 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 746697008231 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 746697008232 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 746697008233 Uncharacterized conserved protein [Function unknown]; Region: COG4198 746697008234 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 746697008235 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 746697008236 catalytic residue [active] 746697008237 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 746697008238 active site 746697008239 catalytic site [active] 746697008240 substrate binding site [chemical binding]; other site 746697008241 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 746697008242 GIY-YIG motif/motif A; other site 746697008243 active site 746697008244 catalytic site [active] 746697008245 putative DNA binding site [nucleotide binding]; other site 746697008246 metal binding site [ion binding]; metal-binding site 746697008247 Ion transport protein; Region: Ion_trans; pfam00520 746697008248 Ion channel; Region: Ion_trans_2; pfam07885 746697008249 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 746697008250 Double zinc ribbon; Region: DZR; pfam12773 746697008251 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 746697008252 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 746697008253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 746697008254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 746697008255 active site 746697008256 phosphorylation site [posttranslational modification] 746697008257 intermolecular recognition site; other site 746697008258 dimerization interface [polypeptide binding]; other site 746697008259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 746697008260 DNA binding site [nucleotide binding] 746697008261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 746697008262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 746697008263 dimer interface [polypeptide binding]; other site 746697008264 phosphorylation site [posttranslational modification] 746697008265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 746697008266 ATP binding site [chemical binding]; other site 746697008267 Mg2+ binding site [ion binding]; other site 746697008268 G-X-G motif; other site 746697008269 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 746697008270 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 746697008271 CoA-binding site [chemical binding]; other site 746697008272 ATP-binding [chemical binding]; other site 746697008273 YbbR-like protein; Region: YbbR; pfam07949 746697008274 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 746697008275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 746697008276 active site 746697008277 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008278 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008279 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008280 Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183 746697008281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 746697008282 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 746697008283 NAD(P) binding site [chemical binding]; other site 746697008284 active site 746697008285 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 746697008286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 746697008287 Walker A/P-loop; other site 746697008288 ATP binding site [chemical binding]; other site 746697008289 Q-loop/lid; other site 746697008290 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 746697008291 ABC transporter signature motif; other site 746697008292 Walker B; other site 746697008293 D-loop; other site 746697008294 H-loop/switch region; other site 746697008295 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 746697008296 Flavoprotein; Region: Flavoprotein; pfam02441 746697008297 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 746697008298 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 746697008299 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 746697008300 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 746697008301 dihydrodipicolinate synthase; Region: dapA; TIGR00674 746697008302 dimer interface [polypeptide binding]; other site 746697008303 active site 746697008304 catalytic residue [active] 746697008305 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 746697008306 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 746697008307 nucleotide binding pocket [chemical binding]; other site 746697008308 K-X-D-G motif; other site 746697008309 catalytic site [active] 746697008310 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 746697008311 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 746697008312 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 746697008313 Dimer interface [polypeptide binding]; other site 746697008314 BRCT sequence motif; other site 746697008315 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 746697008316 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 746697008317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 746697008318 S-adenosylmethionine binding site [chemical binding]; other site 746697008319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 746697008320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 746697008321 Coenzyme A binding pocket [chemical binding]; other site 746697008322 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 746697008323 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 746697008324 catalytic motif [active] 746697008325 Zn binding site [ion binding]; other site 746697008326 RibD C-terminal domain; Region: RibD_C; cl17279 746697008327 Uncharacterized conserved protein [Function unknown]; Region: COG1739 746697008328 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 746697008329 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 746697008330 active site