-- dump date   	20140618_192037
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
866775000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
866775000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
866775000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775000004	Walker A motif; other site
866775000005	ATP binding site [chemical binding]; other site
866775000006	Walker B motif; other site
866775000007	arginine finger; other site
866775000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
866775000009	DnaA box-binding interface [nucleotide binding]; other site
866775000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
866775000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
866775000012	putative DNA binding surface [nucleotide binding]; other site
866775000013	dimer interface [polypeptide binding]; other site
866775000014	beta-clamp/clamp loader binding surface; other site
866775000015	beta-clamp/translesion DNA polymerase binding surface; other site
866775000016	Transposase; Region: DEDD_Tnp_IS110; pfam01548
866775000017	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
866775000018	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
866775000019	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
866775000020	FAD binding domain; Region: FAD_binding_4; pfam01565
866775000021	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
866775000022	recombination protein F; Reviewed; Region: recF; PRK00064
866775000023	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
866775000024	Walker A/P-loop; other site
866775000025	ATP binding site [chemical binding]; other site
866775000026	Q-loop/lid; other site
866775000027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775000028	ABC transporter signature motif; other site
866775000029	Walker B; other site
866775000030	D-loop; other site
866775000031	H-loop/switch region; other site
866775000032	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
866775000033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775000034	Mg2+ binding site [ion binding]; other site
866775000035	G-X-G motif; other site
866775000036	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866775000037	anchoring element; other site
866775000038	dimer interface [polypeptide binding]; other site
866775000039	ATP binding site [chemical binding]; other site
866775000040	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866775000041	active site
866775000042	putative metal-binding site [ion binding]; other site
866775000043	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866775000044	DNA gyrase subunit A; Validated; Region: PRK05560
866775000045	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866775000046	CAP-like domain; other site
866775000047	active site
866775000048	primary dimer interface [polypeptide binding]; other site
866775000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775000055	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
866775000056	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775000057	Walker A/P-loop; other site
866775000058	ATP binding site [chemical binding]; other site
866775000059	Q-loop/lid; other site
866775000060	ABC transporter signature motif; other site
866775000061	Walker B; other site
866775000062	D-loop; other site
866775000063	H-loop/switch region; other site
866775000064	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
866775000065	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
866775000066	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
866775000067	active site
866775000068	homodimer interface [polypeptide binding]; other site
866775000069	homotetramer interface [polypeptide binding]; other site
866775000070	Predicted membrane protein [Function unknown]; Region: COG1288
866775000071	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
866775000072	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866775000073	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866775000074	metal binding site [ion binding]; metal-binding site
866775000075	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
866775000076	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
866775000077	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
866775000078	dimer interface [polypeptide binding]; other site
866775000079	ssDNA binding site [nucleotide binding]; other site
866775000080	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866775000081	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
866775000082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775000083	non-specific DNA binding site [nucleotide binding]; other site
866775000084	salt bridge; other site
866775000085	sequence-specific DNA binding site [nucleotide binding]; other site
866775000086	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
866775000087	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
866775000088	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
866775000089	DHH family; Region: DHH; pfam01368
866775000090	DHHA1 domain; Region: DHHA1; pfam02272
866775000091	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
866775000092	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866775000093	Walker A/P-loop; other site
866775000094	ATP binding site [chemical binding]; other site
866775000095	Q-loop/lid; other site
866775000096	ABC transporter signature motif; other site
866775000097	Walker B; other site
866775000098	D-loop; other site
866775000099	H-loop/switch region; other site
866775000100	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
866775000101	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
866775000102	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
866775000103	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
866775000104	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
866775000105	replicative DNA helicase; Region: DnaB; TIGR00665
866775000106	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
866775000107	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
866775000108	Walker A motif; other site
866775000109	ATP binding site [chemical binding]; other site
866775000110	Walker B motif; other site
866775000111	DNA binding loops [nucleotide binding]
866775000112	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
866775000113	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
866775000114	dimer interface [polypeptide binding]; other site
866775000115	active site
866775000116	metal binding site [ion binding]; metal-binding site
866775000117	YrhK-like protein; Region: YrhK; pfam14145
866775000118	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
866775000119	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
866775000120	metal binding site [ion binding]; metal-binding site
866775000121	dimer interface [polypeptide binding]; other site
866775000122	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
866775000123	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
866775000124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775000125	catalytic residue [active]
866775000126	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
866775000127	argininosuccinate synthase; Provisional; Region: PRK13820
866775000128	ANP binding site [chemical binding]; other site
866775000129	Substrate Binding Site II [chemical binding]; other site
866775000130	Substrate Binding Site I [chemical binding]; other site
866775000131	T-box leader
866775000132	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866775000133	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
866775000134	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
866775000135	active site
866775000136	Isochorismatase family; Region: Isochorismatase; pfam00857
866775000137	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
866775000138	catalytic triad [active]
866775000139	conserved cis-peptide bond; other site
866775000140	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
866775000141	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
866775000142	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
866775000143	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866775000144	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
866775000145	Ligand binding site; other site
866775000146	Putative Catalytic site; other site
866775000147	DXD motif; other site
866775000148	Uncharacterized conserved protein [Function unknown]; Region: COG2966
866775000149	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
866775000150	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
866775000151	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775000152	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000153	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000154	Homeodomain-like domain; Region: HTH_32; pfam13565
866775000155	putative transposase OrfB; Reviewed; Region: PHA02517
866775000156	HTH-like domain; Region: HTH_21; pfam13276
866775000157	Integrase core domain; Region: rve; pfam00665
866775000158	Integrase core domain; Region: rve_2; pfam13333
866775000159	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866775000160	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
866775000161	metal binding site [ion binding]; metal-binding site
866775000162	dimer interface [polypeptide binding]; other site
866775000163	CAAX protease self-immunity; Region: Abi; pfam02517
866775000164	Protein of unknown function (DUF2185); Region: DUF2185; cl02019
866775000165	cystathionine gamma-synthase; Reviewed; Region: PRK08247
866775000166	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
866775000167	homodimer interface [polypeptide binding]; other site
866775000168	substrate-cofactor binding pocket; other site
866775000169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775000170	catalytic residue [active]
866775000171	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866775000172	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866775000173	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866775000174	dimerization interface [polypeptide binding]; other site
866775000175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775000176	Coenzyme A binding pocket [chemical binding]; other site
866775000177	DJ-1 family protein; Region: not_thiJ; TIGR01383
866775000178	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
866775000179	conserved cys residue [active]
866775000180	Haemolytic domain; Region: Haemolytic; cl00506
866775000181	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
866775000182	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
866775000183	active site
866775000184	substrate binding site [chemical binding]; other site
866775000185	metal binding site [ion binding]; metal-binding site
866775000186	YbbR-like protein; Region: YbbR; pfam07949
866775000187	YbbR-like protein; Region: YbbR; pfam07949
866775000188	TIGR00159 family protein; Region: TIGR00159
866775000189	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
866775000190	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
866775000191	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
866775000192	dimerization interface [polypeptide binding]; other site
866775000193	active site
866775000194	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
866775000195	putative transposase OrfB; Reviewed; Region: PHA02517
866775000196	HTH-like domain; Region: HTH_21; pfam13276
866775000197	Integrase core domain; Region: rve; pfam00665
866775000198	Integrase core domain; Region: rve_2; pfam13333
866775000199	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
866775000200	thiamine phosphate binding site [chemical binding]; other site
866775000201	active site
866775000202	pyrophosphate binding site [ion binding]; other site
866775000203	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
866775000204	substrate binding site [chemical binding]; other site
866775000205	dimer interface [polypeptide binding]; other site
866775000206	ATP binding site [chemical binding]; other site
866775000207	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
866775000208	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
866775000209	putative catalytic cysteine [active]
866775000210	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
866775000211	putative active site [active]
866775000212	metal binding site [ion binding]; metal-binding site
866775000213	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
866775000214	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
866775000215	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
866775000216	Peptidase M16C associated; Region: M16C_assoc; pfam08367
866775000217	putative transposase OrfB; Reviewed; Region: PHA02517
866775000218	HTH-like domain; Region: HTH_21; pfam13276
866775000219	Integrase core domain; Region: rve; pfam00665
866775000220	Integrase core domain; Region: rve_2; pfam13333
866775000221	FemAB family; Region: FemAB; pfam02388
866775000222	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
866775000223	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
866775000224	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866775000225	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
866775000226	Uncharacterized conserved protein [Function unknown]; Region: COG0398
866775000227	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
866775000228	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775000229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775000230	active site
866775000231	phosphorylation site [posttranslational modification]
866775000232	intermolecular recognition site; other site
866775000233	dimerization interface [polypeptide binding]; other site
866775000234	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775000235	DNA binding site [nucleotide binding]
866775000236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866775000237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866775000238	dimer interface [polypeptide binding]; other site
866775000239	phosphorylation site [posttranslational modification]
866775000240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775000241	ATP binding site [chemical binding]; other site
866775000242	Mg2+ binding site [ion binding]; other site
866775000243	G-X-G motif; other site
866775000244	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866775000245	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
866775000246	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
866775000247	LytTr DNA-binding domain; Region: LytTR; pfam04397
866775000248	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866775000249	guanine deaminase; Region: guan_deamin; TIGR02967
866775000250	active site
866775000251	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
866775000252	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866775000253	T-box leader
866775000254	seryl-tRNA synthetase; Provisional; Region: PRK05431
866775000255	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
866775000256	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
866775000257	dimer interface [polypeptide binding]; other site
866775000258	active site
866775000259	motif 1; other site
866775000260	motif 2; other site
866775000261	motif 3; other site
866775000262	methionine sulfoxide reductase A; Provisional; Region: PRK14054
866775000263	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
866775000264	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
866775000265	homodimer interface [polypeptide binding]; other site
866775000266	substrate-cofactor binding pocket; other site
866775000267	catalytic residue [active]
866775000268	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
866775000269	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866775000270	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000271	motif II; other site
866775000272	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
866775000273	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866775000274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775000275	homodimer interface [polypeptide binding]; other site
866775000276	catalytic residue [active]
866775000277	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
866775000278	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866775000279	DNA binding residues [nucleotide binding]
866775000280	putative dimer interface [polypeptide binding]; other site
866775000281	L-aspartate oxidase; Provisional; Region: PRK06175
866775000282	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
866775000283	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
866775000284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000285	motif II; other site
866775000286	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
866775000287	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866775000288	active site
866775000289	dimer interface [polypeptide binding]; other site
866775000290	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
866775000291	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000292	motif II; other site
866775000293	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
866775000294	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866775000295	TPP-binding site [chemical binding]; other site
866775000296	dimer interface [polypeptide binding]; other site
866775000297	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866775000298	PYR/PP interface [polypeptide binding]; other site
866775000299	dimer interface [polypeptide binding]; other site
866775000300	TPP binding site [chemical binding]; other site
866775000301	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866775000302	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
866775000303	active site
866775000304	intersubunit interactions; other site
866775000305	catalytic residue [active]
866775000306	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
866775000307	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775000308	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
866775000309	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775000310	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775000311	Walker A/P-loop; other site
866775000312	ATP binding site [chemical binding]; other site
866775000313	Q-loop/lid; other site
866775000314	ABC transporter signature motif; other site
866775000315	Walker B; other site
866775000316	D-loop; other site
866775000317	H-loop/switch region; other site
866775000318	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
866775000319	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866775000320	FtsX-like permease family; Region: FtsX; pfam02687
866775000321	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866775000322	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866775000323	FtsX-like permease family; Region: FtsX; pfam02687
866775000324	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
866775000325	FMN binding site [chemical binding]; other site
866775000326	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
866775000327	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
866775000328	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866775000329	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775000330	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866775000331	catalytic residues [active]
866775000332	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866775000333	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
866775000334	active site
866775000335	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866775000336	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866775000337	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866775000338	dimerization interface [polypeptide binding]; other site
866775000339	enoyl-CoA hydratase; Provisional; Region: PRK06688
866775000340	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866775000341	substrate binding site [chemical binding]; other site
866775000342	oxyanion hole (OAH) forming residues; other site
866775000343	trimer interface [polypeptide binding]; other site
866775000344	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
866775000345	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
866775000346	FMN binding site [chemical binding]; other site
866775000347	substrate binding site [chemical binding]; other site
866775000348	putative catalytic residue [active]
866775000349	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
866775000350	CoA-transferase family III; Region: CoA_transf_3; pfam02515
866775000351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866775000352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866775000353	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866775000354	dimerization interface [polypeptide binding]; other site
866775000355	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866775000356	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866775000357	active site
866775000358	catalytic tetrad [active]
866775000359	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
866775000360	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
866775000361	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
866775000362	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866775000363	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775000364	Coenzyme A binding pocket [chemical binding]; other site
866775000365	Avidin family; Region: Avidin; pfam01382
866775000366	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866775000367	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
866775000368	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866775000369	Walker A/P-loop; other site
866775000370	ATP binding site [chemical binding]; other site
866775000371	Q-loop/lid; other site
866775000372	ABC transporter signature motif; other site
866775000373	Walker B; other site
866775000374	D-loop; other site
866775000375	H-loop/switch region; other site
866775000376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775000377	dimer interface [polypeptide binding]; other site
866775000378	conserved gate region; other site
866775000379	ABC-ATPase subunit interface; other site
866775000380	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
866775000381	Uncharacterized conserved protein [Function unknown]; Region: COG1479
866775000382	Protein of unknown function DUF262; Region: DUF262; pfam03235
866775000383	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
866775000384	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
866775000385	HsdM N-terminal domain; Region: HsdM_N; pfam12161
866775000386	hypothetical protein; Validated; Region: PRK08116
866775000387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775000388	Walker A motif; other site
866775000389	ATP binding site [chemical binding]; other site
866775000390	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
866775000391	Prophage antirepressor [Transcription]; Region: COG3617
866775000392	BRO family, N-terminal domain; Region: Bro-N; smart01040
866775000393	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
866775000394	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
866775000395	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
866775000396	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
866775000397	generic binding surface II; other site
866775000398	generic binding surface I; other site
866775000399	Maff2 family; Region: Maff2; pfam12750
866775000400	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
866775000401	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
866775000402	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
866775000403	cofactor binding site; other site
866775000404	DNA binding site [nucleotide binding]
866775000405	substrate interaction site [chemical binding]; other site
866775000406	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
866775000407	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
866775000408	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
866775000409	putative active site [active]
866775000410	putative NTP binding site [chemical binding]; other site
866775000411	putative nucleic acid binding site [nucleotide binding]; other site
866775000412	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
866775000413	DNA methylase; Region: N6_N4_Mtase; pfam01555
866775000414	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
866775000415	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
866775000416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775000417	S-adenosylmethionine binding site [chemical binding]; other site
866775000418	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
866775000419	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
866775000420	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
866775000421	G1 box; other site
866775000422	putative GEF interaction site [polypeptide binding]; other site
866775000423	GTP/Mg2+ binding site [chemical binding]; other site
866775000424	Switch I region; other site
866775000425	G2 box; other site
866775000426	G3 box; other site
866775000427	Switch II region; other site
866775000428	G4 box; other site
866775000429	G5 box; other site
866775000430	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
866775000431	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
866775000432	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
866775000433	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
866775000434	putative dimer interface [polypeptide binding]; other site
866775000435	catalytic triad [active]
866775000436	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
866775000437	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866775000438	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
866775000439	Virulence protein [General function prediction only]; Region: COG3943
866775000440	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
866775000441	Domain of unknown function (DUF955); Region: DUF955; cl01076
866775000442	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
866775000443	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
866775000444	catalytic residues [active]
866775000445	catalytic nucleophile [active]
866775000446	Recombinase; Region: Recombinase; pfam07508
866775000447	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
866775000448	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
866775000449	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
866775000450	catalytic residues [active]
866775000451	catalytic nucleophile [active]
866775000452	Recombinase; Region: Recombinase; pfam07508
866775000453	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
866775000454	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
866775000455	Methyltransferase domain; Region: Methyltransf_26; pfam13659
866775000456	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
866775000457	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
866775000458	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
866775000459	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
866775000460	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
866775000461	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
866775000462	Int/Topo IB signature motif; other site
866775000463	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
866775000464	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
866775000465	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
866775000466	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
866775000467	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
866775000468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775000469	ATP binding site [chemical binding]; other site
866775000470	putative Mg++ binding site [ion binding]; other site
866775000471	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
866775000472	AAA domain; Region: AAA_14; pfam13173
866775000473	Repair protein; Region: Repair_PSII; pfam04536
866775000474	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866775000475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775000476	non-specific DNA binding site [nucleotide binding]; other site
866775000477	salt bridge; other site
866775000478	sequence-specific DNA binding site [nucleotide binding]; other site
866775000479	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775000480	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000481	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000482	Homeodomain-like domain; Region: HTH_32; pfam13565
866775000483	putative transposase OrfB; Reviewed; Region: PHA02517
866775000484	HTH-like domain; Region: HTH_21; pfam13276
866775000485	Integrase core domain; Region: rve; pfam00665
866775000486	Integrase core domain; Region: rve_2; pfam13333
866775000487	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
866775000488	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
866775000489	DNA-binding interface [nucleotide binding]; DNA binding site
866775000490	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
866775000491	CHAP domain; Region: CHAP; cl17642
866775000492	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; smart01095
866775000493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866775000494	FMN-binding domain; Region: FMN_bind; cl01081
866775000495	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
866775000496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866775000497	NAD(P) binding site [chemical binding]; other site
866775000498	active site
866775000499	FMN-binding domain; Region: FMN_bind; pfam04205
866775000500	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
866775000501	L-aspartate oxidase; Provisional; Region: PRK06175
866775000502	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
866775000503	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866775000504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866775000505	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
866775000506	dimerization interface [polypeptide binding]; other site
866775000507	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
866775000508	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
866775000509	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
866775000510	shikimate binding site; other site
866775000511	NAD(P) binding site [chemical binding]; other site
866775000512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866775000513	putative substrate translocation pore; other site
866775000514	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
866775000515	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
866775000516	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
866775000517	active site
866775000518	catalytic residue [active]
866775000519	dimer interface [polypeptide binding]; other site
866775000520	H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620
866775000521	Citrate transporter; Region: CitMHS; pfam03600
866775000522	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
866775000523	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
866775000524	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866775000525	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
866775000526	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
866775000527	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775000528	active site
866775000529	phosphorylation site [posttranslational modification]
866775000530	intermolecular recognition site; other site
866775000531	dimerization interface [polypeptide binding]; other site
866775000532	Predicted permeases [General function prediction only]; Region: COG0679
866775000533	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
866775000534	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
866775000535	NAD binding site [chemical binding]; other site
866775000536	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
866775000537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866775000538	DNA binding residues [nucleotide binding]
866775000539	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
866775000540	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866775000541	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866775000542	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866775000543	putative active site [active]
866775000544	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
866775000545	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
866775000546	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
866775000547	active site
866775000548	dimer interface [polypeptide binding]; other site
866775000549	magnesium binding site [ion binding]; other site
866775000550	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866775000551	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
866775000552	tetramer interface [polypeptide binding]; other site
866775000553	active site
866775000554	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775000555	active site
866775000556	phosphorylation site [posttranslational modification]
866775000557	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
866775000558	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000559	motif II; other site
866775000560	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
866775000561	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866775000562	active site
866775000563	P-loop; other site
866775000564	phosphorylation site [posttranslational modification]
866775000565	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
866775000566	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775000567	active site
866775000568	phosphorylation site [posttranslational modification]
866775000569	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
866775000570	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
866775000571	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775000572	active site
866775000573	phosphorylation site [posttranslational modification]
866775000574	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
866775000575	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
866775000576	active site
866775000577	P-loop; other site
866775000578	phosphorylation site [posttranslational modification]
866775000579	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866775000580	phosphate binding site [ion binding]; other site
866775000581	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866775000582	PRD domain; Region: PRD; pfam00874
866775000583	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866775000584	active site
866775000585	P-loop; other site
866775000586	phosphorylation site [posttranslational modification]
866775000587	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775000588	active site
866775000589	phosphorylation site [posttranslational modification]
866775000590	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
866775000591	intersubunit interface [polypeptide binding]; other site
866775000592	active site
866775000593	catalytic residue [active]
866775000594	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
866775000595	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
866775000596	TPP-binding site [chemical binding]; other site
866775000597	dimer interface [polypeptide binding]; other site
866775000598	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
866775000599	PYR/PP interface [polypeptide binding]; other site
866775000600	dimer interface [polypeptide binding]; other site
866775000601	TPP binding site [chemical binding]; other site
866775000602	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866775000603	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866775000604	active site
866775000605	P-loop; other site
866775000606	phosphorylation site [posttranslational modification]
866775000607	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
866775000608	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775000609	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000610	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000611	Homeodomain-like domain; Region: HTH_32; pfam13565
866775000612	putative transposase OrfB; Reviewed; Region: PHA02517
866775000613	HTH-like domain; Region: HTH_21; pfam13276
866775000614	Integrase core domain; Region: rve; pfam00665
866775000615	Integrase core domain; Region: rve_2; pfam13333
866775000616	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
866775000617	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866775000618	putative DNA binding site [nucleotide binding]; other site
866775000619	putative Zn2+ binding site [ion binding]; other site
866775000620	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
866775000621	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
866775000622	intersubunit interface [polypeptide binding]; other site
866775000623	active site
866775000624	zinc binding site [ion binding]; other site
866775000625	Na+ binding site [ion binding]; other site
866775000626	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
866775000627	substrate binding site [chemical binding]; other site
866775000628	dimer interface [polypeptide binding]; other site
866775000629	catalytic triad [active]
866775000630	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866775000631	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
866775000632	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
866775000633	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
866775000634	AP (apurinic/apyrimidinic) site pocket; other site
866775000635	DNA interaction; other site
866775000636	Metal-binding active site; metal-binding site
866775000637	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866775000638	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
866775000639	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
866775000640	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
866775000641	Entner-Doudoroff aldolase; Region: eda; TIGR01182
866775000642	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
866775000643	active site
866775000644	intersubunit interface [polypeptide binding]; other site
866775000645	catalytic residue [active]
866775000646	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177
866775000647	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
866775000648	putative ligand binding site [chemical binding]; other site
866775000649	putative NAD binding site [chemical binding]; other site
866775000650	catalytic site [active]
866775000651	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
866775000652	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866775000653	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
866775000654	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
866775000655	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
866775000656	active site
866775000657	phosphorylation site [posttranslational modification]
866775000658	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866775000659	active pocket/dimerization site; other site
866775000660	active site
866775000661	phosphorylation site [posttranslational modification]
866775000662	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866775000663	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172
866775000664	putative ligand binding site [chemical binding]; other site
866775000665	putative NAD binding site [chemical binding]; other site
866775000666	catalytic site [active]
866775000667	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
866775000668	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000669	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
866775000670	putative transposase OrfB; Reviewed; Region: PHA02517
866775000671	HTH-like domain; Region: HTH_21; pfam13276
866775000672	Integrase core domain; Region: rve; pfam00665
866775000673	Integrase core domain; Region: rve_2; pfam13333
866775000674	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775000675	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000676	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000677	Homeodomain-like domain; Region: HTH_32; pfam13565
866775000678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866775000679	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866775000680	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
866775000681	beta-galactosidase; Region: BGL; TIGR03356
866775000682	Uncharacterized conserved protein [Function unknown]; Region: COG3589
866775000683	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
866775000684	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866775000685	Mga helix-turn-helix domain; Region: Mga; pfam05043
866775000686	PRD domain; Region: PRD; pfam00874
866775000687	PRD domain; Region: PRD; pfam00874
866775000688	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866775000689	active site
866775000690	P-loop; other site
866775000691	phosphorylation site [posttranslational modification]
866775000692	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
866775000693	active site
866775000694	phosphorylation site [posttranslational modification]
866775000695	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
866775000696	active site
866775000697	P-loop; other site
866775000698	phosphorylation site [posttranslational modification]
866775000699	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
866775000700	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
866775000701	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
866775000702	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866775000703	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
866775000704	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
866775000705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775000706	dimer interface [polypeptide binding]; other site
866775000707	conserved gate region; other site
866775000708	putative PBP binding loops; other site
866775000709	ABC-ATPase subunit interface; other site
866775000710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775000711	dimer interface [polypeptide binding]; other site
866775000712	conserved gate region; other site
866775000713	ABC-ATPase subunit interface; other site
866775000714	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
866775000715	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000716	motif II; other site
866775000717	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
866775000718	active site
866775000719	intersubunit interactions; other site
866775000720	catalytic residue [active]
866775000721	sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171
866775000722	classical (c) SDRs; Region: SDR_c; cd05233
866775000723	NAD(P) binding site [chemical binding]; other site
866775000724	active site
866775000725	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866775000726	HTH domain; Region: HTH_11; pfam08279
866775000727	PRD domain; Region: PRD; pfam00874
866775000728	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866775000729	active site
866775000730	P-loop; other site
866775000731	phosphorylation site [posttranslational modification]
866775000732	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775000733	active site
866775000734	phosphorylation site [posttranslational modification]
866775000735	Glucitol operon activator protein (GutM); Region: GutM; pfam06923
866775000736	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
866775000737	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
866775000738	PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825
866775000739	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
866775000740	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
866775000741	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
866775000742	intracellular protease, PfpI family; Region: PfpI; TIGR01382
866775000743	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
866775000744	proposed catalytic triad [active]
866775000745	conserved cys residue [active]
866775000746	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
866775000747	CoA-transferase family III; Region: CoA_transf_3; pfam02515
866775000748	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
866775000749	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
866775000750	FMN binding site [chemical binding]; other site
866775000751	substrate binding site [chemical binding]; other site
866775000752	putative catalytic residue [active]
866775000753	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
866775000754	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
866775000755	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
866775000756	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
866775000757	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
866775000758	active site
866775000759	tetramer interface [polypeptide binding]; other site
866775000760	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
866775000761	active site 1 [active]
866775000762	dimer interface [polypeptide binding]; other site
866775000763	hexamer interface [polypeptide binding]; other site
866775000764	active site 2 [active]
866775000765	Protein of unknown function (DUF1700); Region: DUF1700; pfam08006
866775000766	Predicted transcriptional regulators [Transcription]; Region: COG1695
866775000767	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
866775000768	putative DNA binding site [nucleotide binding]; other site
866775000769	putative Zn2+ binding site [ion binding]; other site
866775000770	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866775000771	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866775000772	active site
866775000773	metal binding site [ion binding]; metal-binding site
866775000774	Restriction endonuclease [Defense mechanisms]; Region: COG3587
866775000775	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775000776	ATP binding site [chemical binding]; other site
866775000777	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
866775000778	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866775000779	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
866775000780	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
866775000781	active site
866775000782	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775000783	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000784	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000785	Homeodomain-like domain; Region: HTH_32; pfam13565
866775000786	putative transposase OrfB; Reviewed; Region: PHA02517
866775000787	HTH-like domain; Region: HTH_21; pfam13276
866775000788	Integrase core domain; Region: rve; pfam00665
866775000789	Integrase core domain; Region: rve_2; pfam13333
866775000790	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
866775000791	active site
866775000792	putative substrate binding region [chemical binding]; other site
866775000793	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
866775000794	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866775000795	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
866775000796	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
866775000797	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
866775000798	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866775000799	active site
866775000800	metal binding site [ion binding]; metal-binding site
866775000801	DNA binding site [nucleotide binding]
866775000802	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
866775000803	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
866775000804	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775000805	Walker A/P-loop; other site
866775000806	ATP binding site [chemical binding]; other site
866775000807	Q-loop/lid; other site
866775000808	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
866775000809	putative YPXnL-motif binding site; other site
866775000810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775000811	ABC transporter signature motif; other site
866775000812	Walker B; other site
866775000813	D-loop; other site
866775000814	H-loop/switch region; other site
866775000815	PspC domain; Region: PspC; pfam04024
866775000816	Membrane protein of unknown function; Region: DUF360; cl00850
866775000817	HPr kinase/phosphorylase; Provisional; Region: PRK05428
866775000818	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
866775000819	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
866775000820	Hpr binding site; other site
866775000821	active site
866775000822	homohexamer subunit interaction site [polypeptide binding]; other site
866775000823	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
866775000824	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
866775000825	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
866775000826	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
866775000827	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
866775000828	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
866775000829	active site
866775000830	tetramer interface; other site
866775000831	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
866775000832	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866775000833	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775000834	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
866775000835	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866775000836	putative substrate translocation pore; other site
866775000837	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
866775000838	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
866775000839	active site
866775000840	substrate binding site [chemical binding]; other site
866775000841	metal binding site [ion binding]; metal-binding site
866775000842	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
866775000843	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
866775000844	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
866775000845	phosphate binding site [ion binding]; other site
866775000846	putative substrate binding pocket [chemical binding]; other site
866775000847	dimer interface [polypeptide binding]; other site
866775000848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
866775000849	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
866775000850	FMN-binding domain; Region: FMN_bind; pfam04205
866775000851	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
866775000852	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
866775000853	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
866775000854	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775000855	Coenzyme A binding pocket [chemical binding]; other site
866775000856	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
866775000857	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
866775000858	dimer interface [polypeptide binding]; other site
866775000859	ssDNA binding site [nucleotide binding]; other site
866775000860	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866775000861	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775000862	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775000863	active site
866775000864	phosphorylation site [posttranslational modification]
866775000865	intermolecular recognition site; other site
866775000866	dimerization interface [polypeptide binding]; other site
866775000867	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775000868	DNA binding site [nucleotide binding]
866775000869	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866775000870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866775000871	dimer interface [polypeptide binding]; other site
866775000872	phosphorylation site [posttranslational modification]
866775000873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775000874	ATP binding site [chemical binding]; other site
866775000875	Mg2+ binding site [ion binding]; other site
866775000876	G-X-G motif; other site
866775000877	VanZ like family; Region: VanZ; pfam04892
866775000878	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
866775000879	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
866775000880	putative RNA binding site [nucleotide binding]; other site
866775000881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775000882	S-adenosylmethionine binding site [chemical binding]; other site
866775000883	putative transposase OrfB; Reviewed; Region: PHA02517
866775000884	HTH-like domain; Region: HTH_21; pfam13276
866775000885	Integrase core domain; Region: rve; pfam00665
866775000886	Integrase core domain; Region: rve_2; pfam13333
866775000887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775000888	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000889	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775000890	Homeodomain-like domain; Region: HTH_32; pfam13565
866775000891	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
866775000892	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
866775000893	short chain dehydrogenase; Provisional; Region: PRK12937
866775000894	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866775000895	NAD(P) binding site [chemical binding]; other site
866775000896	active site
866775000897	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
866775000898	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
866775000899	hypothetical protein; Validated; Region: PRK02101
866775000900	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
866775000901	HPr interaction site; other site
866775000902	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866775000903	active site
866775000904	phosphorylation site [posttranslational modification]
866775000905	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
866775000906	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866775000907	HIGH motif; other site
866775000908	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
866775000909	active site
866775000910	KMSKS motif; other site
866775000911	Protein of unknown function, DUF488; Region: DUF488; cl01246
866775000912	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
866775000913	ApbE family; Region: ApbE; pfam02424
866775000914	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
866775000915	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
866775000916	active site
866775000917	catalytic site [active]
866775000918	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000919	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866775000920	active site
866775000921	motif I; other site
866775000922	motif II; other site
866775000923	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775000924	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
866775000925	putative active site [active]
866775000926	putative CoA binding site [chemical binding]; other site
866775000927	nudix motif; other site
866775000928	metal binding site [ion binding]; metal-binding site
866775000929	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866775000930	Predicted membrane protein [Function unknown]; Region: COG4684
866775000931	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
866775000932	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
866775000933	active site
866775000934	uracil binding [chemical binding]; other site
866775000935	xanthine permease; Region: pbuX; TIGR03173
866775000936	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
866775000937	Bacterial sugar transferase; Region: Bac_transf; pfam02397
866775000938	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
866775000939	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
866775000940	active site
866775000941	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
866775000942	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
866775000943	homodimer interface [polypeptide binding]; other site
866775000944	NAD binding pocket [chemical binding]; other site
866775000945	ATP binding pocket [chemical binding]; other site
866775000946	Mg binding site [ion binding]; other site
866775000947	active-site loop [active]
866775000948	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
866775000949	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866775000950	active site
866775000951	HIGH motif; other site
866775000952	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
866775000953	KMSKS motif; other site
866775000954	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
866775000955	tRNA binding surface [nucleotide binding]; other site
866775000956	anticodon binding site; other site
866775000957	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
866775000958	active site
866775000959	metal binding site [ion binding]; metal-binding site
866775000960	dimerization interface [polypeptide binding]; other site
866775000961	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
866775000962	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
866775000963	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866775000964	YacP-like NYN domain; Region: NYN_YacP; pfam05991
866775000965	RNA polymerase factor sigma-70; Validated; Region: PRK08295
866775000966	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866775000967	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
866775000968	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
866775000969	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
866775000970	putative homodimer interface [polypeptide binding]; other site
866775000971	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
866775000972	heterodimer interface [polypeptide binding]; other site
866775000973	homodimer interface [polypeptide binding]; other site
866775000974	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
866775000975	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
866775000976	23S rRNA interface [nucleotide binding]; other site
866775000977	L7/L12 interface [polypeptide binding]; other site
866775000978	putative thiostrepton binding site; other site
866775000979	L25 interface [polypeptide binding]; other site
866775000980	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
866775000981	mRNA/rRNA interface [nucleotide binding]; other site
866775000982	Ribosomal protein L10 leader
866775000983	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
866775000984	23S rRNA interface [nucleotide binding]; other site
866775000985	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
866775000986	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
866775000987	core dimer interface [polypeptide binding]; other site
866775000988	peripheral dimer interface [polypeptide binding]; other site
866775000989	L10 interface [polypeptide binding]; other site
866775000990	L11 interface [polypeptide binding]; other site
866775000991	putative EF-Tu interaction site [polypeptide binding]; other site
866775000992	putative EF-G interaction site [polypeptide binding]; other site
866775000993	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866775000994	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866775000995	DNA binding site [nucleotide binding]
866775000996	domain linker motif; other site
866775000997	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866775000998	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866775000999	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
866775001000	substrate binding site [chemical binding]; other site
866775001001	ATP binding site [chemical binding]; other site
866775001002	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
866775001003	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866775001004	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775001005	S-adenosylmethionine binding site [chemical binding]; other site
866775001006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775001007	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775001008	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775001009	Homeodomain-like domain; Region: HTH_32; pfam13565
866775001010	putative transposase OrfB; Reviewed; Region: PHA02517
866775001011	HTH-like domain; Region: HTH_21; pfam13276
866775001012	Integrase core domain; Region: rve; pfam00665
866775001013	Integrase core domain; Region: rve_2; pfam13333
866775001014	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
866775001015	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
866775001016	Walker A/P-loop; other site
866775001017	ATP binding site [chemical binding]; other site
866775001018	Q-loop/lid; other site
866775001019	ABC transporter signature motif; other site
866775001020	Walker B; other site
866775001021	D-loop; other site
866775001022	H-loop/switch region; other site
866775001023	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
866775001024	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
866775001025	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
866775001026	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
866775001027	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
866775001028	active site
866775001029	catalytic site [active]
866775001030	metal binding site [ion binding]; metal-binding site
866775001031	dimer interface [polypeptide binding]; other site
866775001032	methionine sulfoxide reductase A; Provisional; Region: PRK14054
866775001033	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
866775001034	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
866775001035	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
866775001036	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
866775001037	RPB1 interaction site [polypeptide binding]; other site
866775001038	RPB10 interaction site [polypeptide binding]; other site
866775001039	RPB11 interaction site [polypeptide binding]; other site
866775001040	RPB3 interaction site [polypeptide binding]; other site
866775001041	RPB12 interaction site [polypeptide binding]; other site
866775001042	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
866775001043	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
866775001044	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
866775001045	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
866775001046	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
866775001047	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
866775001048	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
866775001049	DNA binding site [nucleotide binding]
866775001050	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
866775001051	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115
866775001052	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
866775001053	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
866775001054	active site
866775001055	dimer interface [polypeptide binding]; other site
866775001056	effector binding site; other site
866775001057	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
866775001058	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
866775001059	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
866775001060	Protein of unknown function (DUF739); Region: DUF739; pfam05339
866775001061	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
866775001062	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866775001063	Walker A/P-loop; other site
866775001064	ATP binding site [chemical binding]; other site
866775001065	Q-loop/lid; other site
866775001066	ABC transporter signature motif; other site
866775001067	Walker B; other site
866775001068	D-loop; other site
866775001069	H-loop/switch region; other site
866775001070	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
866775001071	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
866775001072	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
866775001073	Clp amino terminal domain; Region: Clp_N; pfam02861
866775001074	Clp amino terminal domain; Region: Clp_N; pfam02861
866775001075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775001076	Walker A motif; other site
866775001077	ATP binding site [chemical binding]; other site
866775001078	Walker B motif; other site
866775001079	arginine finger; other site
866775001080	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775001081	Walker A motif; other site
866775001082	ATP binding site [chemical binding]; other site
866775001083	Walker B motif; other site
866775001084	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866775001085	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
866775001086	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
866775001087	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
866775001088	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
866775001089	nucleoside/Zn binding site; other site
866775001090	dimer interface [polypeptide binding]; other site
866775001091	catalytic motif [active]
866775001092	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
866775001093	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775001094	Walker A motif; other site
866775001095	ATP binding site [chemical binding]; other site
866775001096	Walker B motif; other site
866775001097	arginine finger; other site
866775001098	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
866775001099	hypothetical protein; Validated; Region: PRK00153
866775001100	recombination protein RecR; Reviewed; Region: recR; PRK00076
866775001101	RecR protein; Region: RecR; pfam02132
866775001102	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
866775001103	putative active site [active]
866775001104	putative metal-binding site [ion binding]; other site
866775001105	tetramer interface [polypeptide binding]; other site
866775001106	thymidylate kinase; Validated; Region: tmk; PRK00698
866775001107	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
866775001108	TMP-binding site; other site
866775001109	ATP-binding site [chemical binding]; other site
866775001110	DNA polymerase III subunit delta'; Validated; Region: PRK08058
866775001111	DNA polymerase III subunit delta'; Validated; Region: PRK08485
866775001112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775001113	Coenzyme A binding pocket [chemical binding]; other site
866775001114	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
866775001115	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
866775001116	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775001117	S-adenosylmethionine binding site [chemical binding]; other site
866775001118	Predicted methyltransferases [General function prediction only]; Region: COG0313
866775001119	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
866775001120	putative SAM binding site [chemical binding]; other site
866775001121	putative homodimer interface [polypeptide binding]; other site
866775001122	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866775001123	putative active site [active]
866775001124	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
866775001125	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
866775001126	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
866775001127	aromatic amino acid aminotransferase; Validated; Region: PRK07309
866775001128	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866775001129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775001130	homodimer interface [polypeptide binding]; other site
866775001131	catalytic residue [active]
866775001132	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
866775001133	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866775001134	Zn2+ binding site [ion binding]; other site
866775001135	Mg2+ binding site [ion binding]; other site
866775001136	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
866775001137	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
866775001138	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
866775001139	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
866775001140	hinge; other site
866775001141	active site
866775001142	transcription termination factor Rho; Provisional; Region: rho; PRK09376
866775001143	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
866775001144	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
866775001145	RNA binding site [nucleotide binding]; other site
866775001146	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
866775001147	multimer interface [polypeptide binding]; other site
866775001148	Walker A motif; other site
866775001149	ATP binding site [chemical binding]; other site
866775001150	Walker B motif; other site
866775001151	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
866775001152	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
866775001153	active site
866775001154	catalytic site [active]
866775001155	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
866775001156	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
866775001157	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
866775001158	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
866775001159	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866775001160	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866775001161	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866775001162	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
866775001163	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
866775001164	ATP binding site [chemical binding]; other site
866775001165	Mg++ binding site [ion binding]; other site
866775001166	motif III; other site
866775001167	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775001168	nucleotide binding region [chemical binding]; other site
866775001169	ATP-binding site [chemical binding]; other site
866775001170	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
866775001171	hypothetical protein; Provisional; Region: PRK04164
866775001172	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
866775001173	H+ Antiporter protein; Region: 2A0121; TIGR00900
866775001174	QueT transporter; Region: QueT; pfam06177
866775001175	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
866775001176	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
866775001177	DNA binding residues [nucleotide binding]
866775001178	dimer interface [polypeptide binding]; other site
866775001179	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866775001180	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866775001181	Walker A/P-loop; other site
866775001182	ATP binding site [chemical binding]; other site
866775001183	Q-loop/lid; other site
866775001184	ABC transporter signature motif; other site
866775001185	Walker B; other site
866775001186	D-loop; other site
866775001187	H-loop/switch region; other site
866775001188	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
866775001189	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866775001190	Domain of unknown function DUF21; Region: DUF21; pfam01595
866775001191	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866775001192	Transporter associated domain; Region: CorC_HlyC; smart01091
866775001193	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
866775001194	active site 2 [active]
866775001195	active site 1 [active]
866775001196	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
866775001197	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
866775001198	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
866775001199	Ligand binding site; other site
866775001200	Putative Catalytic site; other site
866775001201	DXD motif; other site
866775001202	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866775001203	catalytic residues [active]
866775001204	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
866775001205	active site
866775001206	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
866775001207	RNAase interaction site [polypeptide binding]; other site
866775001208	Protein of unknown function (DUF975); Region: DUF975; cl10504
866775001209	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
866775001210	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
866775001211	GIY-YIG motif/motif A; other site
866775001212	active site
866775001213	catalytic site [active]
866775001214	putative DNA binding site [nucleotide binding]; other site
866775001215	metal binding site [ion binding]; metal-binding site
866775001216	UvrB/uvrC motif; Region: UVR; pfam02151
866775001217	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
866775001218	phosphodiesterase YaeI; Provisional; Region: PRK11340
866775001219	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
866775001220	putative active site [active]
866775001221	putative metal binding site [ion binding]; other site
866775001222	helicase 45; Provisional; Region: PTZ00424
866775001223	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866775001224	ATP binding site [chemical binding]; other site
866775001225	putative Mg++ binding site [ion binding]; other site
866775001226	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775001227	nucleotide binding region [chemical binding]; other site
866775001228	ATP-binding site [chemical binding]; other site
866775001229	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
866775001230	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
866775001231	Substrate binding site; other site
866775001232	Mg++ binding site; other site
866775001233	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
866775001234	active site
866775001235	substrate binding site [chemical binding]; other site
866775001236	CoA binding site [chemical binding]; other site
866775001237	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
866775001238	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
866775001239	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775001240	active site
866775001241	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
866775001242	putative active site [active]
866775001243	catalytic residue [active]
866775001244	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
866775001245	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
866775001246	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775001247	ATP binding site [chemical binding]; other site
866775001248	putative Mg++ binding site [ion binding]; other site
866775001249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775001250	nucleotide binding region [chemical binding]; other site
866775001251	ATP-binding site [chemical binding]; other site
866775001252	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
866775001253	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866775001254	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866775001255	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775001256	RNA binding surface [nucleotide binding]; other site
866775001257	Septum formation initiator; Region: DivIC; pfam04977
866775001258	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
866775001259	hypothetical protein; Provisional; Region: PRK08582
866775001260	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
866775001261	RNA binding site [nucleotide binding]; other site
866775001262	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
866775001263	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
866775001264	Ligand Binding Site [chemical binding]; other site
866775001265	TilS substrate C-terminal domain; Region: TilS_C; smart00977
866775001266	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775001267	active site
866775001268	FtsH Extracellular; Region: FtsH_ext; pfam06480
866775001269	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
866775001270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775001271	Walker A motif; other site
866775001272	ATP binding site [chemical binding]; other site
866775001273	Walker B motif; other site
866775001274	arginine finger; other site
866775001275	Peptidase family M41; Region: Peptidase_M41; pfam01434
866775001276	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
866775001277	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
866775001278	dimerization interface [polypeptide binding]; other site
866775001279	domain crossover interface; other site
866775001280	redox-dependent activation switch; other site
866775001281	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866775001282	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
866775001283	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866775001284	catalytic residue [active]
866775001285	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
866775001286	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
866775001287	FMN binding site [chemical binding]; other site
866775001288	active site
866775001289	catalytic residues [active]
866775001290	substrate binding site [chemical binding]; other site
866775001291	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
866775001292	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
866775001293	dimer interface [polypeptide binding]; other site
866775001294	putative anticodon binding site; other site
866775001295	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
866775001296	motif 1; other site
866775001297	active site
866775001298	motif 2; other site
866775001299	motif 3; other site
866775001300	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
866775001301	S17 interaction site [polypeptide binding]; other site
866775001302	S8 interaction site; other site
866775001303	16S rRNA interaction site [nucleotide binding]; other site
866775001304	streptomycin interaction site [chemical binding]; other site
866775001305	23S rRNA interaction site [nucleotide binding]; other site
866775001306	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
866775001307	30S ribosomal protein S7; Validated; Region: PRK05302
866775001308	elongation factor G; Reviewed; Region: PRK00007
866775001309	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
866775001310	G1 box; other site
866775001311	putative GEF interaction site [polypeptide binding]; other site
866775001312	GTP/Mg2+ binding site [chemical binding]; other site
866775001313	Switch I region; other site
866775001314	G2 box; other site
866775001315	G3 box; other site
866775001316	Switch II region; other site
866775001317	G4 box; other site
866775001318	G5 box; other site
866775001319	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
866775001320	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
866775001321	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
866775001322	elongation factor Tu; Reviewed; Region: PRK00049
866775001323	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
866775001324	G1 box; other site
866775001325	GEF interaction site [polypeptide binding]; other site
866775001326	GTP/Mg2+ binding site [chemical binding]; other site
866775001327	Switch I region; other site
866775001328	G2 box; other site
866775001329	G3 box; other site
866775001330	Switch II region; other site
866775001331	G4 box; other site
866775001332	G5 box; other site
866775001333	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
866775001334	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
866775001335	Antibiotic Binding Site [chemical binding]; other site
866775001336	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
866775001337	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
866775001338	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
866775001339	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
866775001340	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
866775001341	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
866775001342	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
866775001343	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
866775001344	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
866775001345	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
866775001346	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
866775001347	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
866775001348	putative translocon binding site; other site
866775001349	protein-rRNA interface [nucleotide binding]; other site
866775001350	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
866775001351	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
866775001352	G-X-X-G motif; other site
866775001353	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
866775001354	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
866775001355	23S rRNA interface [nucleotide binding]; other site
866775001356	5S rRNA interface [nucleotide binding]; other site
866775001357	putative antibiotic binding site [chemical binding]; other site
866775001358	L25 interface [polypeptide binding]; other site
866775001359	L27 interface [polypeptide binding]; other site
866775001360	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
866775001361	23S rRNA interface [nucleotide binding]; other site
866775001362	putative translocon interaction site; other site
866775001363	signal recognition particle (SRP54) interaction site; other site
866775001364	L23 interface [polypeptide binding]; other site
866775001365	trigger factor interaction site; other site
866775001366	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
866775001367	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
866775001368	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
866775001369	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
866775001370	RNA binding site [nucleotide binding]; other site
866775001371	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
866775001372	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
866775001373	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
866775001374	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
866775001375	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
866775001376	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866775001377	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
866775001378	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
866775001379	23S rRNA interface [nucleotide binding]; other site
866775001380	L21e interface [polypeptide binding]; other site
866775001381	5S rRNA interface [nucleotide binding]; other site
866775001382	L27 interface [polypeptide binding]; other site
866775001383	L5 interface [polypeptide binding]; other site
866775001384	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
866775001385	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
866775001386	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
866775001387	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
866775001388	23S rRNA binding site [nucleotide binding]; other site
866775001389	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
866775001390	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
866775001391	SecY translocase; Region: SecY; pfam00344
866775001392	adenylate kinase; Reviewed; Region: adk; PRK00279
866775001393	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
866775001394	AMP-binding site [chemical binding]; other site
866775001395	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
866775001396	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
866775001397	rRNA binding site [nucleotide binding]; other site
866775001398	predicted 30S ribosome binding site; other site
866775001399	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
866775001400	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
866775001401	30S ribosomal protein S13; Region: bact_S13; TIGR03631
866775001402	30S ribosomal protein S11; Validated; Region: PRK05309
866775001403	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
866775001404	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
866775001405	alphaNTD - beta interaction site [polypeptide binding]; other site
866775001406	alphaNTD homodimer interface [polypeptide binding]; other site
866775001407	alphaNTD - beta' interaction site [polypeptide binding]; other site
866775001408	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
866775001409	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
866775001410	Acyltransferase family; Region: Acyl_transf_3; pfam01757
866775001411	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
866775001412	active site
866775001413	catalytic triad [active]
866775001414	oxyanion hole [active]
866775001415	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
866775001416	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866775001417	Walker A/P-loop; other site
866775001418	ATP binding site [chemical binding]; other site
866775001419	Q-loop/lid; other site
866775001420	ABC transporter signature motif; other site
866775001421	Walker B; other site
866775001422	D-loop; other site
866775001423	H-loop/switch region; other site
866775001424	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
866775001425	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866775001426	Walker A/P-loop; other site
866775001427	ATP binding site [chemical binding]; other site
866775001428	Q-loop/lid; other site
866775001429	ABC transporter signature motif; other site
866775001430	Walker B; other site
866775001431	D-loop; other site
866775001432	H-loop/switch region; other site
866775001433	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866775001434	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
866775001435	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
866775001436	dimerization interface 3.5A [polypeptide binding]; other site
866775001437	active site
866775001438	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
866775001439	Ribosomal protein L13 leader
866775001440	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
866775001441	23S rRNA interface [nucleotide binding]; other site
866775001442	L3 interface [polypeptide binding]; other site
866775001443	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
866775001444	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775001445	G5 domain; Region: G5; pfam07501
866775001446	G5 domain; Region: G5; pfam07501
866775001447	G5 domain; Region: G5; pfam07501
866775001448	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
866775001449	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866775001450	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866775001451	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
866775001452	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
866775001453	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
866775001454	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
866775001455	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
866775001456	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
866775001457	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
866775001458	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866775001459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866775001460	putative substrate translocation pore; other site
866775001461	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866775001462	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866775001463	phosphate binding site [ion binding]; other site
866775001464	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
866775001465	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866775001466	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866775001467	endonuclease III; Region: ENDO3c; smart00478
866775001468	minor groove reading motif; other site
866775001469	helix-hairpin-helix signature motif; other site
866775001470	substrate binding pocket [chemical binding]; other site
866775001471	active site
866775001472	FMN-binding domain; Region: FMN_bind; cl01081
866775001473	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
866775001474	Inhibitor of growth proteins N-terminal histone-binding; Region: ING; pfam12998
866775001475	L-aspartate oxidase; Provisional; Region: PRK06175
866775001476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001477	ABC-ATPase subunit interface; other site
866775001478	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
866775001479	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
866775001480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775001481	Walker A/P-loop; other site
866775001482	ATP binding site [chemical binding]; other site
866775001483	Q-loop/lid; other site
866775001484	ABC transporter signature motif; other site
866775001485	Walker B; other site
866775001486	D-loop; other site
866775001487	H-loop/switch region; other site
866775001488	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
866775001489	ectoine utilization protein EutC; Validated; Region: PRK08291
866775001490	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
866775001491	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
866775001492	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
866775001493	dimer interface [polypeptide binding]; other site
866775001494	FMN binding site [chemical binding]; other site
866775001495	NADPH bind site [chemical binding]; other site
866775001496	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866775001497	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866775001498	active site
866775001499	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
866775001500	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866775001501	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
866775001502	NAD binding site [chemical binding]; other site
866775001503	dimer interface [polypeptide binding]; other site
866775001504	substrate binding site [chemical binding]; other site
866775001505	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
866775001506	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775001507	substrate binding pocket [chemical binding]; other site
866775001508	membrane-bound complex binding site; other site
866775001509	hinge residues; other site
866775001510	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
866775001511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001512	dimer interface [polypeptide binding]; other site
866775001513	conserved gate region; other site
866775001514	putative PBP binding loops; other site
866775001515	ABC-ATPase subunit interface; other site
866775001516	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
866775001517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001518	dimer interface [polypeptide binding]; other site
866775001519	conserved gate region; other site
866775001520	putative PBP binding loops; other site
866775001521	ABC-ATPase subunit interface; other site
866775001522	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866775001523	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866775001524	active site
866775001525	metal binding site [ion binding]; metal-binding site
866775001526	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
866775001527	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
866775001528	NADP binding site [chemical binding]; other site
866775001529	dimer interface [polypeptide binding]; other site
866775001530	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
866775001531	cytosine deaminase; Provisional; Region: PRK09230
866775001532	active site
866775001533	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
866775001534	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
866775001535	putative active site [active]
866775001536	putative FMN binding site [chemical binding]; other site
866775001537	putative substrate binding site [chemical binding]; other site
866775001538	putative catalytic residue [active]
866775001539	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
866775001540	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
866775001541	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
866775001542	Conserved TM helix; Region: TM_helix; pfam05552
866775001543	Conserved TM helix; Region: TM_helix; pfam05552
866775001544	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
866775001545	lipoyl attachment site [posttranslational modification]; other site
866775001546	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
866775001547	putative ADP-ribose binding site [chemical binding]; other site
866775001548	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
866775001549	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
866775001550	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866775001551	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
866775001552	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
866775001553	D-lactate dehydrogenase; Validated; Region: PRK08605
866775001554	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
866775001555	homodimer interface [polypeptide binding]; other site
866775001556	ligand binding site [chemical binding]; other site
866775001557	NAD binding site [chemical binding]; other site
866775001558	catalytic site [active]
866775001559	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866775001560	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775001561	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
866775001562	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
866775001563	NAD binding site [chemical binding]; other site
866775001564	homodimer interface [polypeptide binding]; other site
866775001565	active site
866775001566	substrate binding site [chemical binding]; other site
866775001567	uracil transporter; Provisional; Region: PRK10720
866775001568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775001569	non-specific DNA binding site [nucleotide binding]; other site
866775001570	salt bridge; other site
866775001571	sequence-specific DNA binding site [nucleotide binding]; other site
866775001572	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775001573	non-specific DNA binding site [nucleotide binding]; other site
866775001574	salt bridge; other site
866775001575	sequence-specific DNA binding site [nucleotide binding]; other site
866775001576	RecX family; Region: RecX; cl00936
866775001577	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
866775001578	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866775001579	minor groove reading motif; other site
866775001580	helix-hairpin-helix signature motif; other site
866775001581	substrate binding pocket [chemical binding]; other site
866775001582	active site
866775001583	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
866775001584	DNA binding and oxoG recognition site [nucleotide binding]
866775001585	hypothetical protein; Provisional; Region: PRK13662
866775001586	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
866775001587	pullulanase, type I; Region: pulA_typeI; TIGR02104
866775001588	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
866775001589	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
866775001590	Ca binding site [ion binding]; other site
866775001591	active site
866775001592	catalytic site [active]
866775001593	Predicted membrane protein [Function unknown]; Region: COG4129
866775001594	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
866775001595	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
866775001596	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
866775001597	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
866775001598	Int/Topo IB signature motif; other site
866775001599	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
866775001600	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775001601	non-specific DNA binding site [nucleotide binding]; other site
866775001602	salt bridge; other site
866775001603	sequence-specific DNA binding site [nucleotide binding]; other site
866775001604	Chromate transporter; Region: Chromate_transp; pfam02417
866775001605	Chromate transporter; Region: Chromate_transp; pfam02417
866775001606	FMN-binding domain; Region: FMN_bind; pfam04205
866775001607	FMN-binding domain; Region: FMN_bind; pfam04205
866775001608	PAS domain; Region: PAS_10; pfam13596
866775001609	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775001610	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775001611	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775001612	Homeodomain-like domain; Region: HTH_32; pfam13565
866775001613	putative transposase OrfB; Reviewed; Region: PHA02517
866775001614	HTH-like domain; Region: HTH_21; pfam13276
866775001615	Integrase core domain; Region: rve; pfam00665
866775001616	Integrase core domain; Region: rve_2; pfam13333
866775001617	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866775001618	Uncharacterized conserved protein [Function unknown]; Region: COG1434
866775001619	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
866775001620	putative active site [active]
866775001621	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
866775001622	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
866775001623	active site
866775001624	metal binding site [ion binding]; metal-binding site
866775001625	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866775001626	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866775001627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001628	dimer interface [polypeptide binding]; other site
866775001629	conserved gate region; other site
866775001630	putative PBP binding loops; other site
866775001631	ABC-ATPase subunit interface; other site
866775001632	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866775001633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001634	dimer interface [polypeptide binding]; other site
866775001635	conserved gate region; other site
866775001636	putative PBP binding loops; other site
866775001637	ABC-ATPase subunit interface; other site
866775001638	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
866775001639	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
866775001640	Walker A/P-loop; other site
866775001641	ATP binding site [chemical binding]; other site
866775001642	Q-loop/lid; other site
866775001643	ABC transporter signature motif; other site
866775001644	Walker B; other site
866775001645	D-loop; other site
866775001646	H-loop/switch region; other site
866775001647	TOBE domain; Region: TOBE_2; pfam08402
866775001648	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
866775001649	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866775001650	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
866775001651	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
866775001652	active site
866775001653	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
866775001654	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
866775001655	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
866775001656	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
866775001657	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
866775001658	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
866775001659	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
866775001660	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
866775001661	Cornifin (SPRR) family; Region: Cornifin; pfam02389
866775001662	SnoaL-like domain; Region: SnoaL_4; pfam13577
866775001663	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
866775001664	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
866775001665	nucleotide binding site/active site [active]
866775001666	HIT family signature motif; other site
866775001667	catalytic residue [active]
866775001668	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866775001669	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866775001670	DNA binding site [nucleotide binding]
866775001671	domain linker motif; other site
866775001672	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
866775001673	dimerization interface [polypeptide binding]; other site
866775001674	ligand binding site [chemical binding]; other site
866775001675	sodium binding site [ion binding]; other site
866775001676	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
866775001677	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
866775001678	substrate binding [chemical binding]; other site
866775001679	active site
866775001680	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
866775001681	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
866775001682	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866775001683	active site turn [active]
866775001684	phosphorylation site [posttranslational modification]
866775001685	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866775001686	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
866775001687	HPr interaction site; other site
866775001688	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866775001689	active site
866775001690	phosphorylation site [posttranslational modification]
866775001691	Thiamine monophosphate synthase/TENI; Region: TMP-TENI; cl17228
866775001692	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_1; cd12161
866775001693	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866775001694	putative ligand binding site [chemical binding]; other site
866775001695	putative NAD binding site [chemical binding]; other site
866775001696	catalytic site [active]
866775001697	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775001698	active site
866775001699	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
866775001700	Transglycosylase; Region: Transgly; pfam00912
866775001701	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866775001702	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866775001703	hypothetical protein; Provisional; Region: PRK13676
866775001704	Uncharacterized conserved protein [Function unknown]; Region: COG4717
866775001705	P-loop containing region of AAA domain; Region: AAA_29; cl17516
866775001706	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
866775001707	Q-loop/lid; other site
866775001708	ABC transporter signature motif; other site
866775001709	Walker B; other site
866775001710	D-loop; other site
866775001711	H-loop/switch region; other site
866775001712	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
866775001713	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
866775001714	generic binding surface II; other site
866775001715	generic binding surface I; other site
866775001716	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
866775001717	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866775001718	Zn2+ binding site [ion binding]; other site
866775001719	Mg2+ binding site [ion binding]; other site
866775001720	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
866775001721	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
866775001722	Ligand binding site; other site
866775001723	metal-binding site
866775001724	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
866775001725	SurA N-terminal domain; Region: SurA_N_3; cl07813
866775001726	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
866775001727	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
866775001728	nucleotide binding site/active site [active]
866775001729	HIT family signature motif; other site
866775001730	catalytic residue [active]
866775001731	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866775001732	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866775001733	Walker A/P-loop; other site
866775001734	ATP binding site [chemical binding]; other site
866775001735	Q-loop/lid; other site
866775001736	ABC transporter signature motif; other site
866775001737	Walker B; other site
866775001738	D-loop; other site
866775001739	H-loop/switch region; other site
866775001740	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
866775001741	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
866775001742	Phosphotransferase enzyme family; Region: APH; pfam01636
866775001743	active site
866775001744	substrate binding site [chemical binding]; other site
866775001745	ATP binding site [chemical binding]; other site
866775001746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775001747	S-adenosylmethionine binding site [chemical binding]; other site
866775001748	Predicted small secreted protein [Function unknown]; Region: COG5584
866775001749	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
866775001750	putative tRNA-binding site [nucleotide binding]; other site
866775001751	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
866775001752	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866775001753	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866775001754	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866775001755	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
866775001756	active site
866775001757	tetramer interface; other site
866775001758	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
866775001759	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
866775001760	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866775001761	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866775001762	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775001763	catalytic core [active]
866775001764	T-box leader
866775001765	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
866775001766	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
866775001767	HIGH motif; other site
866775001768	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866775001769	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866775001770	active site
866775001771	KMSKS motif; other site
866775001772	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
866775001773	tRNA binding surface [nucleotide binding]; other site
866775001774	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
866775001775	substrate binding site [chemical binding]; other site
866775001776	ATP binding site [chemical binding]; other site
866775001777	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866775001778	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775001779	Walker A/P-loop; other site
866775001780	ATP binding site [chemical binding]; other site
866775001781	Q-loop/lid; other site
866775001782	ABC transporter signature motif; other site
866775001783	Walker B; other site
866775001784	D-loop; other site
866775001785	H-loop/switch region; other site
866775001786	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775001787	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775001788	substrate binding pocket [chemical binding]; other site
866775001789	membrane-bound complex binding site; other site
866775001790	hinge residues; other site
866775001791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001792	dimer interface [polypeptide binding]; other site
866775001793	conserved gate region; other site
866775001794	putative PBP binding loops; other site
866775001795	ABC-ATPase subunit interface; other site
866775001796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775001797	dimer interface [polypeptide binding]; other site
866775001798	conserved gate region; other site
866775001799	putative PBP binding loops; other site
866775001800	ABC-ATPase subunit interface; other site
866775001801	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
866775001802	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866775001803	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866775001804	dipeptidase PepV; Reviewed; Region: PRK07318
866775001805	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
866775001806	active site
866775001807	metal binding site [ion binding]; metal-binding site
866775001808	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
866775001809	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
866775001810	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
866775001811	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
866775001812	Predicted transcriptional regulators [Transcription]; Region: COG1733
866775001813	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
866775001814	T-box leader
866775001815	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
866775001816	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
866775001817	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
866775001818	dimer interface [polypeptide binding]; other site
866775001819	motif 1; other site
866775001820	active site
866775001821	motif 2; other site
866775001822	motif 3; other site
866775001823	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
866775001824	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
866775001825	putative tRNA-binding site [nucleotide binding]; other site
866775001826	B3/4 domain; Region: B3_4; pfam03483
866775001827	tRNA synthetase B5 domain; Region: B5; smart00874
866775001828	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
866775001829	dimer interface [polypeptide binding]; other site
866775001830	motif 1; other site
866775001831	motif 3; other site
866775001832	motif 2; other site
866775001833	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
866775001834	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866775001835	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
866775001836	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
866775001837	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
866775001838	exopolyphosphatase; Region: exo_poly_only; TIGR03706
866775001839	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
866775001840	polyphosphate kinase; Provisional; Region: PRK05443
866775001841	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
866775001842	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
866775001843	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
866775001844	putative domain interface [polypeptide binding]; other site
866775001845	putative active site [active]
866775001846	catalytic site [active]
866775001847	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
866775001848	putative domain interface [polypeptide binding]; other site
866775001849	putative active site [active]
866775001850	catalytic site [active]
866775001851	hypothetical protein; Provisional; Region: PRK13690
866775001852	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
866775001853	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
866775001854	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
866775001855	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
866775001856	FAD binding domain; Region: FAD_binding_4; pfam01565
866775001857	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
866775001858	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
866775001859	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775001860	Walker A/P-loop; other site
866775001861	ATP binding site [chemical binding]; other site
866775001862	ABC transporter signature motif; other site
866775001863	Walker B; other site
866775001864	D-loop; other site
866775001865	H-loop/switch region; other site
866775001866	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
866775001867	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775001868	Walker A/P-loop; other site
866775001869	ATP binding site [chemical binding]; other site
866775001870	Q-loop/lid; other site
866775001871	ABC transporter signature motif; other site
866775001872	Walker B; other site
866775001873	D-loop; other site
866775001874	H-loop/switch region; other site
866775001875	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775001876	catalytic core [active]
866775001877	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866775001878	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866775001879	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
866775001880	zinc binding site [ion binding]; other site
866775001881	putative ligand binding site [chemical binding]; other site
866775001882	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866775001883	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
866775001884	TM-ABC transporter signature motif; other site
866775001885	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
866775001886	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775001887	Walker A/P-loop; other site
866775001888	ATP binding site [chemical binding]; other site
866775001889	Q-loop/lid; other site
866775001890	ABC transporter signature motif; other site
866775001891	Walker B; other site
866775001892	D-loop; other site
866775001893	H-loop/switch region; other site
866775001894	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866775001895	Transglycosylase; Region: Transgly; pfam00912
866775001896	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866775001897	hypothetical protein; Validated; Region: PRK00110
866775001898	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
866775001899	trimer interface [polypeptide binding]; other site
866775001900	active site
866775001901	G bulge; other site
866775001902	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775001903	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775001904	Walker A/P-loop; other site
866775001905	ATP binding site [chemical binding]; other site
866775001906	Q-loop/lid; other site
866775001907	ABC transporter signature motif; other site
866775001908	Walker B; other site
866775001909	D-loop; other site
866775001910	H-loop/switch region; other site
866775001911	Uncharacterized membrane protein [Function unknown]; Region: COG3949
866775001912	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
866775001913	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
866775001914	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866775001915	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866775001916	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866775001917	DNA binding site [nucleotide binding]
866775001918	domain linker motif; other site
866775001919	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866775001920	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
866775001921	active site
866775001922	active pocket/dimerization site; other site
866775001923	phosphorylation site [posttranslational modification]
866775001924	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
866775001925	active site
866775001926	phosphorylation site [posttranslational modification]
866775001927	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
866775001928	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775001929	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775001930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775001931	Walker A/P-loop; other site
866775001932	ATP binding site [chemical binding]; other site
866775001933	Q-loop/lid; other site
866775001934	ABC transporter signature motif; other site
866775001935	Walker B; other site
866775001936	D-loop; other site
866775001937	H-loop/switch region; other site
866775001938	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775001939	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775001940	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866775001941	Walker A/P-loop; other site
866775001942	ATP binding site [chemical binding]; other site
866775001943	Q-loop/lid; other site
866775001944	ABC transporter signature motif; other site
866775001945	Walker B; other site
866775001946	D-loop; other site
866775001947	H-loop/switch region; other site
866775001948	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
866775001949	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
866775001950	intersubunit interface [polypeptide binding]; other site
866775001951	active site
866775001952	catalytic residue [active]
866775001953	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
866775001954	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866775001955	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
866775001956	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
866775001957	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775001958	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
866775001959	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775001960	FAD binding domain; Region: FAD_binding_2; pfam00890
866775001961	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
866775001962	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
866775001963	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866775001964	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866775001965	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866775001966	putative active site [active]
866775001967	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
866775001968	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
866775001969	putative active site cavity [active]
866775001970	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
866775001971	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866775001972	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866775001973	active site turn [active]
866775001974	phosphorylation site [posttranslational modification]
866775001975	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
866775001976	HPr interaction site; other site
866775001977	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866775001978	active site
866775001979	phosphorylation site [posttranslational modification]
866775001980	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
866775001981	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
866775001982	active site
866775001983	dimer interface [polypeptide binding]; other site
866775001984	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
866775001985	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
866775001986	dimer interface [polypeptide binding]; other site
866775001987	putative radical transfer pathway; other site
866775001988	diiron center [ion binding]; other site
866775001989	tyrosyl radical; other site
866775001990	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
866775001991	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187
866775001992	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
866775001993	Class I ribonucleotide reductase; Region: RNR_I; cd01679
866775001994	active site
866775001995	dimer interface [polypeptide binding]; other site
866775001996	catalytic residues [active]
866775001997	effector binding site; other site
866775001998	R2 peptide binding site; other site
866775001999	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775002000	catalytic core [active]
866775002001	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775002002	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775002003	catalytic core [active]
866775002004	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775002005	Predicted flavoprotein [General function prediction only]; Region: COG0431
866775002006	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866775002007	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
866775002008	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
866775002009	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
866775002010	PYR/PP interface [polypeptide binding]; other site
866775002011	dimer interface [polypeptide binding]; other site
866775002012	tetramer interface [polypeptide binding]; other site
866775002013	TPP binding site [chemical binding]; other site
866775002014	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
866775002015	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
866775002016	TPP-binding site [chemical binding]; other site
866775002017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775002018	non-specific DNA binding site [nucleotide binding]; other site
866775002019	salt bridge; other site
866775002020	sequence-specific DNA binding site [nucleotide binding]; other site
866775002021	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
866775002022	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
866775002023	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
866775002024	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866775002025	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775002026	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775002027	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775002028	Homeodomain-like domain; Region: HTH_32; pfam13565
866775002029	putative transposase OrfB; Reviewed; Region: PHA02517
866775002030	HTH-like domain; Region: HTH_21; pfam13276
866775002031	Integrase core domain; Region: rve; pfam00665
866775002032	Integrase core domain; Region: rve_2; pfam13333
866775002033	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
866775002034	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
866775002035	Walker A/P-loop; other site
866775002036	ATP binding site [chemical binding]; other site
866775002037	Q-loop/lid; other site
866775002038	ABC transporter signature motif; other site
866775002039	Walker B; other site
866775002040	D-loop; other site
866775002041	H-loop/switch region; other site
866775002042	TOBE domain; Region: TOBE_2; pfam08402
866775002043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775002044	dimer interface [polypeptide binding]; other site
866775002045	conserved gate region; other site
866775002046	putative PBP binding loops; other site
866775002047	ABC-ATPase subunit interface; other site
866775002048	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
866775002049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775002050	dimer interface [polypeptide binding]; other site
866775002051	conserved gate region; other site
866775002052	putative PBP binding loops; other site
866775002053	ABC-ATPase subunit interface; other site
866775002054	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
866775002055	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
866775002056	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
866775002057	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
866775002058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866775002059	DNA-binding site [nucleotide binding]; DNA binding site
866775002060	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866775002061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775002062	homodimer interface [polypeptide binding]; other site
866775002063	catalytic residue [active]
866775002064	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
866775002065	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
866775002066	active site
866775002067	multimer interface [polypeptide binding]; other site
866775002068	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
866775002069	predicted active site [active]
866775002070	catalytic triad [active]
866775002071	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
866775002072	Uncharacterized conserved protein [Function unknown]; Region: COG2966
866775002073	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
866775002074	Protein of unknown function (DUF975); Region: DUF975; cl10504
866775002075	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866775002076	Predicted flavoprotein [General function prediction only]; Region: COG0431
866775002077	DNA polymerase IV; Reviewed; Region: PRK03103
866775002078	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
866775002079	active site
866775002080	DNA binding site [nucleotide binding]
866775002081	T-box leader
866775002082	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866775002083	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866775002084	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
866775002085	amidohydrolase; Region: amidohydrolases; TIGR01891
866775002086	metal binding site [ion binding]; metal-binding site
866775002087	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
866775002088	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
866775002089	Rib/alpha-like repeat; Region: Rib; cl07159
866775002090	Rib/alpha-like repeat; Region: Rib; cl07159
866775002091	Rib/alpha-like repeat; Region: Rib; cl07159
866775002092	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
866775002093	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
866775002094	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
866775002095	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
866775002096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866775002097	ATP binding site [chemical binding]; other site
866775002098	putative Mg++ binding site [ion binding]; other site
866775002099	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
866775002100	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
866775002101	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
866775002102	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
866775002103	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866775002104	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
866775002105	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866775002106	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
866775002107	putative glycosyl transferase; Provisional; Region: PRK10073
866775002108	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866775002109	active site
866775002110	EamA-like transporter family; Region: EamA; pfam00892
866775002111	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
866775002112	EamA-like transporter family; Region: EamA; pfam00892
866775002113	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
866775002114	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
866775002115	active site
866775002116	nucleophile elbow; other site
866775002117	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866775002118	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866775002119	serine O-acetyltransferase; Region: cysE; TIGR01172
866775002120	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
866775002121	trimer interface [polypeptide binding]; other site
866775002122	active site
866775002123	substrate binding site [chemical binding]; other site
866775002124	CoA binding site [chemical binding]; other site
866775002125	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
866775002126	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
866775002127	dimer interface [polypeptide binding]; other site
866775002128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775002129	catalytic residue [active]
866775002130	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
866775002131	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
866775002132	homotetramer interface [polypeptide binding]; other site
866775002133	FMN binding site [chemical binding]; other site
866775002134	homodimer contacts [polypeptide binding]; other site
866775002135	putative active site [active]
866775002136	putative substrate binding site [chemical binding]; other site
866775002137	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
866775002138	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866775002139	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
866775002140	diphosphomevalonate decarboxylase; Region: PLN02407
866775002141	mevalonate kinase; Region: mevalon_kin; TIGR00549
866775002142	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866775002143	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866775002144	GMP synthase; Reviewed; Region: guaA; PRK00074
866775002145	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
866775002146	AMP/PPi binding site [chemical binding]; other site
866775002147	candidate oxyanion hole; other site
866775002148	catalytic triad [active]
866775002149	potential glutamine specificity residues [chemical binding]; other site
866775002150	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
866775002151	ATP Binding subdomain [chemical binding]; other site
866775002152	Dimerization subdomain; other site
866775002153	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
866775002154	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930
866775002155	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
866775002156	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775002157	Coenzyme A binding pocket [chemical binding]; other site
866775002158	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
866775002159	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
866775002160	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
866775002161	homodimer interaction site [polypeptide binding]; other site
866775002162	cofactor binding site; other site
866775002163	LemA family; Region: LemA; cl00742
866775002164	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
866775002165	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
866775002166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866775002167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775002168	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775002169	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775002170	Walker A/P-loop; other site
866775002171	ATP binding site [chemical binding]; other site
866775002172	Q-loop/lid; other site
866775002173	ABC transporter signature motif; other site
866775002174	Walker B; other site
866775002175	D-loop; other site
866775002176	H-loop/switch region; other site
866775002177	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866775002178	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866775002179	FtsX-like permease family; Region: FtsX; pfam02687
866775002180	Domain of unknown function (DUF368); Region: DUF368; pfam04018
866775002181	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
866775002182	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866775002183	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866775002184	active site turn [active]
866775002185	phosphorylation site [posttranslational modification]
866775002186	Cell division protein ZapA; Region: ZapA; pfam05164
866775002187	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
866775002188	MutS domain III; Region: MutS_III; pfam05192
866775002189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775002190	Walker A/P-loop; other site
866775002191	ATP binding site [chemical binding]; other site
866775002192	Q-loop/lid; other site
866775002193	ABC transporter signature motif; other site
866775002194	Walker B; other site
866775002195	D-loop; other site
866775002196	H-loop/switch region; other site
866775002197	Smr domain; Region: Smr; pfam01713
866775002198	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866775002199	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
866775002200	catalytic residues [active]
866775002201	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
866775002202	active site
866775002203	dimer interfaces [polypeptide binding]; other site
866775002204	catalytic residues [active]
866775002205	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
866775002206	glutamate racemase; Provisional; Region: PRK00865
866775002207	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
866775002208	active site
866775002209	metal binding site [ion binding]; metal-binding site
866775002210	homotetramer interface [polypeptide binding]; other site
866775002211	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866775002212	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866775002213	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
866775002214	YtxH-like protein; Region: YtxH; pfam12732
866775002215	ATP synthase subunit D; Region: ATP-synt_D; pfam01813
866775002216	V-type ATP synthase subunit B; Provisional; Region: PRK04196
866775002217	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866775002218	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
866775002219	Walker A motif homologous position; other site
866775002220	Walker B motif; other site
866775002221	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866775002222	V-type ATP synthase subunit A; Provisional; Region: PRK04192
866775002223	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866775002224	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
866775002225	Walker A motif/ATP binding site; other site
866775002226	Walker B motif; other site
866775002227	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866775002228	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990
866775002229	ATP synthase subunit C; Region: ATP-synt_C; cl00466
866775002230	V-type ATP synthase subunit I; Validated; Region: PRK05771
866775002231	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
866775002232	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
866775002233	Type II/IV secretion system protein; Region: T2SE; pfam00437
866775002234	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
866775002235	Walker A motif; other site
866775002236	ATP binding site [chemical binding]; other site
866775002237	Walker B motif; other site
866775002238	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
866775002239	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
866775002240	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
866775002241	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
866775002242	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
866775002243	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
866775002244	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
866775002245	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
866775002246	active site
866775002247	elongation factor P; Validated; Region: PRK00529
866775002248	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
866775002249	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
866775002250	RNA binding site [nucleotide binding]; other site
866775002251	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
866775002252	RNA binding site [nucleotide binding]; other site
866775002253	Asp23 family; Region: Asp23; pfam03780
866775002254	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
866775002255	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
866775002256	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
866775002257	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
866775002258	homodimer interface [polypeptide binding]; other site
866775002259	NADP binding site [chemical binding]; other site
866775002260	substrate binding site [chemical binding]; other site
866775002261	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
866775002262	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
866775002263	generic binding surface II; other site
866775002264	generic binding surface I; other site
866775002265	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
866775002266	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
866775002267	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
866775002268	substrate binding pocket [chemical binding]; other site
866775002269	chain length determination region; other site
866775002270	substrate-Mg2+ binding site; other site
866775002271	catalytic residues [active]
866775002272	aspartate-rich region 1; other site
866775002273	active site lid residues [active]
866775002274	aspartate-rich region 2; other site
866775002275	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
866775002276	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775002277	RNA binding surface [nucleotide binding]; other site
866775002278	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
866775002279	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
866775002280	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866775002281	Walker A/P-loop; other site
866775002282	ATP binding site [chemical binding]; other site
866775002283	Q-loop/lid; other site
866775002284	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
866775002285	ABC transporter signature motif; other site
866775002286	Walker B; other site
866775002287	D-loop; other site
866775002288	H-loop/switch region; other site
866775002289	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
866775002290	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
866775002291	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
866775002292	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
866775002293	HflX GTPase family; Region: HflX; cd01878
866775002294	G1 box; other site
866775002295	GTP/Mg2+ binding site [chemical binding]; other site
866775002296	Switch I region; other site
866775002297	G2 box; other site
866775002298	G3 box; other site
866775002299	Switch II region; other site
866775002300	G4 box; other site
866775002301	G5 box; other site
866775002302	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775002303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775002304	active site
866775002305	phosphorylation site [posttranslational modification]
866775002306	intermolecular recognition site; other site
866775002307	dimerization interface [polypeptide binding]; other site
866775002308	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775002309	DNA binding site [nucleotide binding]
866775002310	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866775002311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866775002312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866775002313	dimer interface [polypeptide binding]; other site
866775002314	phosphorylation site [posttranslational modification]
866775002315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775002316	ATP binding site [chemical binding]; other site
866775002317	Mg2+ binding site [ion binding]; other site
866775002318	G-X-G motif; other site
866775002319	hypothetical protein; Validated; Region: PRK07121
866775002320	Predicted oxidoreductase [General function prediction only]; Region: COG3573
866775002321	FMN-binding domain; Region: FMN_bind; pfam04205
866775002322	putative transposase OrfB; Reviewed; Region: PHA02517
866775002323	HTH-like domain; Region: HTH_21; pfam13276
866775002324	Integrase core domain; Region: rve; pfam00665
866775002325	Integrase core domain; Region: rve_2; pfam13333
866775002326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775002327	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775002328	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775002329	Homeodomain-like domain; Region: HTH_32; pfam13565
866775002330	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866775002331	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
866775002332	Chain length determinant protein; Region: Wzz; cl15801
866775002333	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
866775002334	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866775002335	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
866775002336	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
866775002337	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
866775002338	NAD(P) binding site [chemical binding]; other site
866775002339	homodimer interface [polypeptide binding]; other site
866775002340	substrate binding site [chemical binding]; other site
866775002341	active site
866775002342	Bacterial sugar transferase; Region: Bac_transf; pfam02397
866775002343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866775002344	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
866775002345	NAD(P) binding site [chemical binding]; other site
866775002346	active site
866775002347	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
866775002348	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866775002349	putative ADP-binding pocket [chemical binding]; other site
866775002350	putative glycosyl transferase; Provisional; Region: PRK10073
866775002351	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866775002352	active site
866775002353	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866775002354	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
866775002355	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
866775002356	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
866775002357	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
866775002358	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
866775002359	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
866775002360	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
866775002361	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
866775002362	active site
866775002363	catalytic triad [active]
866775002364	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775002365	active site
866775002366	phosphorylation site [posttranslational modification]
866775002367	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
866775002368	active site
866775002369	P-loop; other site
866775002370	phosphorylation site [posttranslational modification]
866775002371	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
866775002372	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866775002373	active site
866775002374	catalytic site [active]
866775002375	substrate binding site [chemical binding]; other site
866775002376	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
866775002377	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775002378	non-specific DNA binding site [nucleotide binding]; other site
866775002379	salt bridge; other site
866775002380	sequence-specific DNA binding site [nucleotide binding]; other site
866775002381	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
866775002382	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
866775002383	Zn binding site [ion binding]; other site
866775002384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775002385	non-specific DNA binding site [nucleotide binding]; other site
866775002386	salt bridge; other site
866775002387	sequence-specific DNA binding site [nucleotide binding]; other site
866775002388	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
866775002389	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
866775002390	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866775002391	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775002392	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866775002393	active site
866775002394	motif I; other site
866775002395	motif II; other site
866775002396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775002397	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775002398	Predicted integral membrane protein [Function unknown]; Region: COG5652
866775002399	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
866775002400	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
866775002401	substrate binding site [chemical binding]; other site
866775002402	dimer interface [polypeptide binding]; other site
866775002403	ATP binding site [chemical binding]; other site
866775002404	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
866775002405	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
866775002406	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
866775002407	ArsC family; Region: ArsC; pfam03960
866775002408	putative ArsC-like catalytic residues; other site
866775002409	putative TRX-like catalytic residues [active]
866775002410	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
866775002411	lipoyl attachment site [posttranslational modification]; other site
866775002412	Tubby C 2; Region: Tub_2; cl02043
866775002413	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
866775002414	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
866775002415	catalytic triad [active]
866775002416	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
866775002417	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
866775002418	active site
866775002419	Zn binding site [ion binding]; other site
866775002420	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775002421	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866775002422	peptide binding site [polypeptide binding]; other site
866775002423	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775002424	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866775002425	peptide binding site [polypeptide binding]; other site
866775002426	peptidase T; Region: peptidase-T; TIGR01882
866775002427	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
866775002428	metal binding site [ion binding]; metal-binding site
866775002429	dimer interface [polypeptide binding]; other site
866775002430	putative phosphoketolase; Provisional; Region: PRK05261
866775002431	XFP N-terminal domain; Region: XFP_N; pfam09364
866775002432	XFP C-terminal domain; Region: XFP_C; pfam09363
866775002433	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
866775002434	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
866775002435	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
866775002436	active site
866775002437	HIGH motif; other site
866775002438	KMSK motif region; other site
866775002439	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
866775002440	tRNA binding surface [nucleotide binding]; other site
866775002441	anticodon binding site; other site
866775002442	Rib/alpha-like repeat; Region: Rib; pfam08428
866775002443	Rib/alpha-like repeat; Region: Rib; pfam08428
866775002444	Rib/alpha-like repeat; Region: Rib; pfam08428
866775002445	Pollen proteins Ole e I like; Region: Pollen_Ole_e_I; pfam01190
866775002446	O-Antigen ligase; Region: Wzy_C; pfam04932
866775002447	glutathione reductase; Validated; Region: PRK06116
866775002448	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775002449	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866775002450	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866775002451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775002452	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
866775002453	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
866775002454	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866775002455	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775002456	non-specific DNA binding site [nucleotide binding]; other site
866775002457	salt bridge; other site
866775002458	sequence-specific DNA binding site [nucleotide binding]; other site
866775002459	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
866775002460	Methyltransferase domain; Region: Methyltransf_23; pfam13489
866775002461	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775002462	S-adenosylmethionine binding site [chemical binding]; other site
866775002463	Predicted flavoprotein [General function prediction only]; Region: COG0431
866775002464	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866775002465	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
866775002466	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
866775002467	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
866775002468	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
866775002469	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866775002470	MarR family; Region: MarR_2; pfam12802
866775002471	Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969
866775002472	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
866775002473	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
866775002474	ATP-grasp domain; Region: ATP-grasp; pfam02222
866775002475	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
866775002476	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
866775002477	ATP binding site [chemical binding]; other site
866775002478	active site
866775002479	substrate binding site [chemical binding]; other site
866775002480	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
866775002481	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
866775002482	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
866775002483	putative active site [active]
866775002484	catalytic triad [active]
866775002485	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
866775002486	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
866775002487	dimerization interface [polypeptide binding]; other site
866775002488	ATP binding site [chemical binding]; other site
866775002489	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
866775002490	dimerization interface [polypeptide binding]; other site
866775002491	ATP binding site [chemical binding]; other site
866775002492	amidophosphoribosyltransferase; Provisional; Region: PRK07272
866775002493	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
866775002494	active site
866775002495	tetramer interface [polypeptide binding]; other site
866775002496	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775002497	active site
866775002498	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
866775002499	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
866775002500	dimerization interface [polypeptide binding]; other site
866775002501	putative ATP binding site [chemical binding]; other site
866775002502	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
866775002503	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
866775002504	active site
866775002505	substrate binding site [chemical binding]; other site
866775002506	cosubstrate binding site; other site
866775002507	catalytic site [active]
866775002508	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
866775002509	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
866775002510	purine monophosphate binding site [chemical binding]; other site
866775002511	dimer interface [polypeptide binding]; other site
866775002512	putative catalytic residues [active]
866775002513	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
866775002514	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
866775002515	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
866775002516	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
866775002517	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
866775002518	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
866775002519	adenylosuccinate lyase; Provisional; Region: PRK07492
866775002520	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
866775002521	tetramer interface [polypeptide binding]; other site
866775002522	active site
866775002523	Predicted metalloprotease [General function prediction only]; Region: COG2321
866775002524	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
866775002525	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
866775002526	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775002527	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866775002528	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
866775002529	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
866775002530	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866775002531	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
866775002532	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775002533	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866775002534	yybP-ykoY leader
866775002535	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
866775002536	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
866775002537	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
866775002538	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
866775002539	RNA binding site [nucleotide binding]; other site
866775002540	hypothetical protein; Provisional; Region: PRK04351
866775002541	SprT homologues; Region: SprT; cl01182
866775002542	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
866775002543	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
866775002544	NAD binding site [chemical binding]; other site
866775002545	dimer interface [polypeptide binding]; other site
866775002546	tetramer (dimer of dimers) interface [polypeptide binding]; other site
866775002547	substrate binding site [chemical binding]; other site
866775002548	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
866775002549	propionate/acetate kinase; Provisional; Region: PRK12379
866775002550	glycerol kinase; Provisional; Region: glpK; PRK00047
866775002551	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
866775002552	N- and C-terminal domain interface [polypeptide binding]; other site
866775002553	active site
866775002554	MgATP binding site [chemical binding]; other site
866775002555	catalytic site [active]
866775002556	metal binding site [ion binding]; metal-binding site
866775002557	glycerol binding site [chemical binding]; other site
866775002558	homotetramer interface [polypeptide binding]; other site
866775002559	homodimer interface [polypeptide binding]; other site
866775002560	FBP binding site [chemical binding]; other site
866775002561	protein IIAGlc interface [polypeptide binding]; other site
866775002562	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
866775002563	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
866775002564	amphipathic channel; other site
866775002565	Asn-Pro-Ala signature motifs; other site
866775002566	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866775002567	Ligand Binding Site [chemical binding]; other site
866775002568	recombination factor protein RarA; Reviewed; Region: PRK13342
866775002569	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775002570	Walker A motif; other site
866775002571	ATP binding site [chemical binding]; other site
866775002572	Walker B motif; other site
866775002573	arginine finger; other site
866775002574	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
866775002575	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
866775002576	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866775002577	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866775002578	catalytic residue [active]
866775002579	Putative amino acid metabolism; Region: DUF1831; pfam08866
866775002580	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
866775002581	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
866775002582	Ligand Binding Site [chemical binding]; other site
866775002583	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
866775002584	AAA domain; Region: AAA_30; pfam13604
866775002585	Family description; Region: UvrD_C_2; pfam13538
866775002586	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
866775002587	T-box leader
866775002588	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
866775002589	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
866775002590	motif 1; other site
866775002591	active site
866775002592	motif 2; other site
866775002593	motif 3; other site
866775002594	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866775002595	DHHA1 domain; Region: DHHA1; pfam02272
866775002596	hypothetical protein; Provisional; Region: PRK05473
866775002597	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
866775002598	hypothetical protein; Provisional; Region: PRK13678
866775002599	YceG-like family; Region: YceG; pfam02618
866775002600	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
866775002601	dimerization interface [polypeptide binding]; other site
866775002602	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
866775002603	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
866775002604	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
866775002605	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
866775002606	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
866775002607	dimer interface [polypeptide binding]; other site
866775002608	active site
866775002609	CoA binding pocket [chemical binding]; other site
866775002610	acyl carrier protein; Provisional; Region: acpP; PRK00982
866775002611	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
866775002612	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
866775002613	FMN binding site [chemical binding]; other site
866775002614	substrate binding site [chemical binding]; other site
866775002615	putative catalytic residue [active]
866775002616	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
866775002617	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
866775002618	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
866775002619	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
866775002620	NAD(P) binding site [chemical binding]; other site
866775002621	active site
866775002622	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
866775002623	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
866775002624	dimer interface [polypeptide binding]; other site
866775002625	active site
866775002626	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
866775002627	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866775002628	carboxyltransferase (CT) interaction site; other site
866775002629	biotinylation site [posttranslational modification]; other site
866775002630	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
866775002631	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
866775002632	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866775002633	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
866775002634	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
866775002635	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
866775002636	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
866775002637	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; COG0825
866775002638	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
866775002639	RNA/DNA hybrid binding site [nucleotide binding]; other site
866775002640	active site
866775002641	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
866775002642	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775002643	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
866775002644	Mechanosensitive ion channel; Region: MS_channel; pfam00924
866775002645	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
866775002646	hypothetical protein; Validated; Region: PRK07121
866775002647	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
866775002648	Uncharacterized membrane protein [Function unknown]; Region: COG3949
866775002649	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
866775002650	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
866775002651	active site
866775002652	Na/Ca binding site [ion binding]; other site
866775002653	catalytic site [active]
866775002654	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866775002655	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
866775002656	active site
866775002657	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
866775002658	putative transposase OrfB; Reviewed; Region: PHA02517
866775002659	HTH-like domain; Region: HTH_21; pfam13276
866775002660	Integrase core domain; Region: rve; pfam00665
866775002661	Integrase core domain; Region: rve_2; pfam13333
866775002662	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775002663	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775002664	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775002665	Homeodomain-like domain; Region: HTH_32; pfam13565
866775002666	AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293
866775002667	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
866775002668	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
866775002669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775002670	cell division protein GpsB; Provisional; Region: PRK14127
866775002671	DivIVA domain; Region: DivI1A_domain; TIGR03544
866775002672	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
866775002673	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775002674	S-adenosylmethionine binding site [chemical binding]; other site
866775002675	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
866775002676	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866775002677	Zn2+ binding site [ion binding]; other site
866775002678	Mg2+ binding site [ion binding]; other site
866775002679	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
866775002680	synthetase active site [active]
866775002681	NTP binding site [chemical binding]; other site
866775002682	metal binding site [ion binding]; metal-binding site
866775002683	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
866775002684	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
866775002685	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
866775002686	putative active site [active]
866775002687	dimerization interface [polypeptide binding]; other site
866775002688	putative tRNAtyr binding site [nucleotide binding]; other site
866775002689	Bacterial SH3 domain homologues; Region: SH3b; smart00287
866775002690	Bacterial SH3 domain; Region: SH3_3; cl17532
866775002691	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866775002692	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866775002693	active site
866775002694	metal binding site [ion binding]; metal-binding site
866775002695	HTH domain; Region: HTH_11; pfam08279
866775002696	PRD domain; Region: PRD; pfam00874
866775002697	PRD domain; Region: PRD; pfam00874
866775002698	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866775002699	active site
866775002700	P-loop; other site
866775002701	phosphorylation site [posttranslational modification]
866775002702	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866775002703	active site
866775002704	P-loop; other site
866775002705	phosphorylation site [posttranslational modification]
866775002706	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775002707	active site
866775002708	phosphorylation site [posttranslational modification]
866775002709	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
866775002710	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866775002711	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866775002712	substrate binding site [chemical binding]; other site
866775002713	hexamer interface [polypeptide binding]; other site
866775002714	metal binding site [ion binding]; metal-binding site
866775002715	T-box leader
866775002716	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
866775002717	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
866775002718	dimer interface [polypeptide binding]; other site
866775002719	motif 1; other site
866775002720	active site
866775002721	motif 2; other site
866775002722	motif 3; other site
866775002723	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
866775002724	anticodon binding site; other site
866775002725	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
866775002726	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
866775002727	dimer interface [polypeptide binding]; other site
866775002728	anticodon binding site; other site
866775002729	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
866775002730	homodimer interface [polypeptide binding]; other site
866775002731	motif 1; other site
866775002732	active site
866775002733	motif 2; other site
866775002734	GAD domain; Region: GAD; pfam02938
866775002735	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
866775002736	active site
866775002737	motif 3; other site
866775002738	RDD family; Region: RDD; pfam06271
866775002739	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
866775002740	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
866775002741	metal binding site 2 [ion binding]; metal-binding site
866775002742	putative DNA binding helix; other site
866775002743	metal binding site 1 [ion binding]; metal-binding site
866775002744	dimer interface [polypeptide binding]; other site
866775002745	structural Zn2+ binding site [ion binding]; other site
866775002746	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
866775002747	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
866775002748	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
866775002749	ligand binding site [chemical binding]; other site
866775002750	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
866775002751	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775002752	Walker A/P-loop; other site
866775002753	ATP binding site [chemical binding]; other site
866775002754	Q-loop/lid; other site
866775002755	ABC transporter signature motif; other site
866775002756	Walker B; other site
866775002757	D-loop; other site
866775002758	H-loop/switch region; other site
866775002759	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
866775002760	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866775002761	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
866775002762	TM-ABC transporter signature motif; other site
866775002763	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
866775002764	active site
866775002765	dimerization interface [polypeptide binding]; other site
866775002766	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
866775002767	Yqey-like protein; Region: YqeY; pfam09424
866775002768	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
866775002769	PhoH-like protein; Region: PhoH; pfam02562
866775002770	metal-binding heat shock protein; Provisional; Region: PRK00016
866775002771	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
866775002772	GTPase Era; Reviewed; Region: era; PRK00089
866775002773	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
866775002774	G1 box; other site
866775002775	GTP/Mg2+ binding site [chemical binding]; other site
866775002776	Switch I region; other site
866775002777	G2 box; other site
866775002778	Switch II region; other site
866775002779	G3 box; other site
866775002780	G4 box; other site
866775002781	G5 box; other site
866775002782	KH domain; Region: KH_2; pfam07650
866775002783	G-X-X-G motif; other site
866775002784	Recombination protein O N terminal; Region: RecO_N; pfam11967
866775002785	DNA repair protein RecO; Region: reco; TIGR00613
866775002786	Recombination protein O C terminal; Region: RecO_C; pfam02565
866775002787	T-box leader
866775002788	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
866775002789	motif 1; other site
866775002790	dimer interface [polypeptide binding]; other site
866775002791	active site
866775002792	motif 2; other site
866775002793	motif 3; other site
866775002794	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
866775002795	DALR anticodon binding domain; Region: DALR_1; pfam05746
866775002796	GTPase CgtA; Reviewed; Region: obgE; PRK12297
866775002797	GTP1/OBG; Region: GTP1_OBG; pfam01018
866775002798	Obg GTPase; Region: Obg; cd01898
866775002799	G1 box; other site
866775002800	GTP/Mg2+ binding site [chemical binding]; other site
866775002801	Switch I region; other site
866775002802	G2 box; other site
866775002803	G3 box; other site
866775002804	Switch II region; other site
866775002805	G4 box; other site
866775002806	G5 box; other site
866775002807	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
866775002808	ribonuclease Z; Region: RNase_Z; TIGR02651
866775002809	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775002810	active site
866775002811	LexA repressor; Validated; Region: PRK00215
866775002812	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
866775002813	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
866775002814	Catalytic site [active]
866775002815	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
866775002816	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
866775002817	Domain of unknown function (DUF814); Region: DUF814; pfam05670
866775002818	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
866775002819	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
866775002820	catalytic motif [active]
866775002821	Zn binding site [ion binding]; other site
866775002822	glutamate dehydrogenase; Provisional; Region: PRK09414
866775002823	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
866775002824	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
866775002825	NAD(P) binding site [chemical binding]; other site
866775002826	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
866775002827	putative substrate binding site [chemical binding]; other site
866775002828	putative ATP binding site [chemical binding]; other site
866775002829	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
866775002830	putative deacylase active site [active]
866775002831	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
866775002832	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
866775002833	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
866775002834	minor groove reading motif; other site
866775002835	helix-hairpin-helix signature motif; other site
866775002836	substrate binding pocket [chemical binding]; other site
866775002837	active site
866775002838	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866775002839	Ligand Binding Site [chemical binding]; other site
866775002840	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
866775002841	Ligand Binding Site [chemical binding]; other site
866775002842	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
866775002843	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
866775002844	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
866775002845	Predicted integral membrane protein [Function unknown]; Region: COG0392
866775002846	Uncharacterized conserved protein [Function unknown]; Region: COG2898
866775002847	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
866775002848	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
866775002849	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
866775002850	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
866775002851	active site turn [active]
866775002852	phosphorylation site [posttranslational modification]
866775002853	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
866775002854	HPr interaction site; other site
866775002855	glycerol kinase (GK) interaction site [polypeptide binding]; other site
866775002856	active site
866775002857	phosphorylation site [posttranslational modification]
866775002858	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
866775002859	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
866775002860	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866775002861	Predicted flavoprotein [General function prediction only]; Region: COG0431
866775002862	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
866775002863	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
866775002864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3001
866775002865	Phosphotransferase enzyme family; Region: APH; pfam01636
866775002866	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
866775002867	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775002868	active site
866775002869	motif I; other site
866775002870	motif II; other site
866775002871	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775002872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775002873	ATP binding site [chemical binding]; other site
866775002874	Walker B motif; other site
866775002875	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
866775002876	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
866775002877	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
866775002878	E-class dimer interface [polypeptide binding]; other site
866775002879	P-class dimer interface [polypeptide binding]; other site
866775002880	active site
866775002881	Cu2+ binding site [ion binding]; other site
866775002882	Zn2+ binding site [ion binding]; other site
866775002883	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
866775002884	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
866775002885	metal binding site [ion binding]; metal-binding site
866775002886	dimer interface [polypeptide binding]; other site
866775002887	T-box leader
866775002888	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
866775002889	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
866775002890	Walker A/P-loop; other site
866775002891	ATP binding site [chemical binding]; other site
866775002892	Q-loop/lid; other site
866775002893	ABC transporter signature motif; other site
866775002894	Walker B; other site
866775002895	D-loop; other site
866775002896	H-loop/switch region; other site
866775002897	FOG: CBS domain [General function prediction only]; Region: COG0517
866775002898	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
866775002899	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775002900	dimer interface [polypeptide binding]; other site
866775002901	conserved gate region; other site
866775002902	putative PBP binding loops; other site
866775002903	ABC-ATPase subunit interface; other site
866775002904	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
866775002905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775002906	dimer interface [polypeptide binding]; other site
866775002907	ABC-ATPase subunit interface; other site
866775002908	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866775002909	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
866775002910	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
866775002911	dimer interface [polypeptide binding]; other site
866775002912	catalytic triad [active]
866775002913	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775002914	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775002915	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775002916	Walker A/P-loop; other site
866775002917	ATP binding site [chemical binding]; other site
866775002918	Q-loop/lid; other site
866775002919	ABC transporter signature motif; other site
866775002920	Walker B; other site
866775002921	D-loop; other site
866775002922	H-loop/switch region; other site
866775002923	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
866775002924	catalytic center binding site [active]
866775002925	ATP binding site [chemical binding]; other site
866775002926	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
866775002927	fructuronate transporter; Provisional; Region: PRK10034; cl15264
866775002928	FMN-binding domain; Region: FMN_bind; pfam04205
866775002929	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
866775002930	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
866775002931	L-aspartate oxidase; Provisional; Region: PRK06175
866775002932	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
866775002933	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
866775002934	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
866775002935	putative active site [active]
866775002936	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
866775002937	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775002938	Walker A/P-loop; other site
866775002939	ATP binding site [chemical binding]; other site
866775002940	Q-loop/lid; other site
866775002941	ABC transporter signature motif; other site
866775002942	Walker B; other site
866775002943	D-loop; other site
866775002944	H-loop/switch region; other site
866775002945	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866775002946	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
866775002947	TM-ABC transporter signature motif; other site
866775002948	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
866775002949	zinc binding site [ion binding]; other site
866775002950	putative ligand binding site [chemical binding]; other site
866775002951	LysE type translocator; Region: LysE; cl00565
866775002952	stage V sporulation protein K; Region: spore_V_K; TIGR02881
866775002953	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775002954	Walker A motif; other site
866775002955	ATP binding site [chemical binding]; other site
866775002956	Walker B motif; other site
866775002957	arginine finger; other site
866775002958	stage V sporulation protein K; Region: spore_V_K; TIGR02881
866775002959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775002960	Walker A motif; other site
866775002961	ATP binding site [chemical binding]; other site
866775002962	Walker B motif; other site
866775002963	arginine finger; other site
866775002964	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
866775002965	DHH family; Region: DHH; pfam01368
866775002966	DHHA2 domain; Region: DHHA2; pfam02833
866775002967	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
866775002968	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
866775002969	CAP-like domain; other site
866775002970	active site
866775002971	primary dimer interface [polypeptide binding]; other site
866775002972	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
866775002973	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
866775002974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775002975	Mg2+ binding site [ion binding]; other site
866775002976	G-X-G motif; other site
866775002977	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
866775002978	anchoring element; other site
866775002979	dimer interface [polypeptide binding]; other site
866775002980	ATP binding site [chemical binding]; other site
866775002981	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
866775002982	active site
866775002983	putative metal-binding site [ion binding]; other site
866775002984	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
866775002985	transcriptional repressor CodY; Validated; Region: PRK04158
866775002986	CodY GAF-like domain; Region: CodY; pfam06018
866775002987	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
866775002988	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
866775002989	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
866775002990	active site
866775002991	DNA binding site [nucleotide binding]
866775002992	Int/Topo IB signature motif; other site
866775002993	DNA topoisomerase I; Validated; Region: PRK05582
866775002994	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
866775002995	active site
866775002996	interdomain interaction site; other site
866775002997	putative metal-binding site [ion binding]; other site
866775002998	nucleotide binding site [chemical binding]; other site
866775002999	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
866775003000	domain I; other site
866775003001	DNA binding groove [nucleotide binding]
866775003002	phosphate binding site [ion binding]; other site
866775003003	domain II; other site
866775003004	domain III; other site
866775003005	nucleotide binding site [chemical binding]; other site
866775003006	catalytic site [active]
866775003007	domain IV; other site
866775003008	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866775003009	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
866775003010	DNA protecting protein DprA; Region: dprA; TIGR00732
866775003011	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
866775003012	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
866775003013	RNA/DNA hybrid binding site [nucleotide binding]; other site
866775003014	active site
866775003015	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
866775003016	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
866775003017	GTP/Mg2+ binding site [chemical binding]; other site
866775003018	G4 box; other site
866775003019	G5 box; other site
866775003020	G1 box; other site
866775003021	Switch I region; other site
866775003022	G2 box; other site
866775003023	G3 box; other site
866775003024	Switch II region; other site
866775003025	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
866775003026	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
866775003027	Catalytic site [active]
866775003028	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
866775003029	C-terminal peptidase (prc); Region: prc; TIGR00225
866775003030	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
866775003031	protein binding site [polypeptide binding]; other site
866775003032	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
866775003033	Catalytic dyad [active]
866775003034	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
866775003035	Protein of unknown function (DUF1250); Region: DUF1250; cl11485
866775003036	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
866775003037	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
866775003038	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
866775003039	folate binding site [chemical binding]; other site
866775003040	NADP+ binding site [chemical binding]; other site
866775003041	thymidylate synthase; Region: thym_sym; TIGR03284
866775003042	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
866775003043	dimerization interface [polypeptide binding]; other site
866775003044	active site
866775003045	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866775003046	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775003047	Walker A/P-loop; other site
866775003048	ATP binding site [chemical binding]; other site
866775003049	Q-loop/lid; other site
866775003050	ABC transporter signature motif; other site
866775003051	Walker B; other site
866775003052	D-loop; other site
866775003053	H-loop/switch region; other site
866775003054	ABC transporter; Region: ABC_tran_2; pfam12848
866775003055	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775003056	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
866775003057	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
866775003058	Potassium binding sites [ion binding]; other site
866775003059	Cesium cation binding sites [ion binding]; other site
866775003060	PemK-like protein; Region: PemK; pfam02452
866775003061	GTP-binding protein LepA; Provisional; Region: PRK05433
866775003062	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
866775003063	G1 box; other site
866775003064	putative GEF interaction site [polypeptide binding]; other site
866775003065	GTP/Mg2+ binding site [chemical binding]; other site
866775003066	Switch I region; other site
866775003067	G2 box; other site
866775003068	G3 box; other site
866775003069	Switch II region; other site
866775003070	G4 box; other site
866775003071	G5 box; other site
866775003072	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
866775003073	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
866775003074	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
866775003075	putative transposase OrfB; Reviewed; Region: PHA02517
866775003076	HTH-like domain; Region: HTH_21; pfam13276
866775003077	Integrase core domain; Region: rve; pfam00665
866775003078	Integrase core domain; Region: rve_2; pfam13333
866775003079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775003080	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003081	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003082	Homeodomain-like domain; Region: HTH_32; pfam13565
866775003083	chaperone protein DnaJ; Provisional; Region: PRK14276
866775003084	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
866775003085	HSP70 interaction site [polypeptide binding]; other site
866775003086	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
866775003087	substrate binding site [polypeptide binding]; other site
866775003088	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
866775003089	Zn binding sites [ion binding]; other site
866775003090	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
866775003091	dimer interface [polypeptide binding]; other site
866775003092	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
866775003093	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
866775003094	nucleotide binding site [chemical binding]; other site
866775003095	NEF interaction site [polypeptide binding]; other site
866775003096	SBD interface [polypeptide binding]; other site
866775003097	heat shock protein GrpE; Provisional; Region: PRK14140
866775003098	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
866775003099	dimer interface [polypeptide binding]; other site
866775003100	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
866775003101	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
866775003102	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
866775003103	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
866775003104	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
866775003105	active site
866775003106	Riboflavin kinase; Region: Flavokinase; pfam01687
866775003107	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
866775003108	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775003109	ATP binding site [chemical binding]; other site
866775003110	putative Mg++ binding site [ion binding]; other site
866775003111	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775003112	nucleotide binding region [chemical binding]; other site
866775003113	ATP-binding site [chemical binding]; other site
866775003114	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
866775003115	HRDC domain; Region: HRDC; pfam00570
866775003116	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
866775003117	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866775003118	NAD(P) binding site [chemical binding]; other site
866775003119	catalytic residues [active]
866775003120	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
866775003121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775003122	Walker A/P-loop; other site
866775003123	ATP binding site [chemical binding]; other site
866775003124	Q-loop/lid; other site
866775003125	ABC transporter signature motif; other site
866775003126	Walker B; other site
866775003127	D-loop; other site
866775003128	H-loop/switch region; other site
866775003129	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866775003130	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
866775003131	TM-ABC transporter signature motif; other site
866775003132	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
866775003133	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
866775003134	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
866775003135	putative RNA binding cleft [nucleotide binding]; other site
866775003136	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
866775003137	NusA N-terminal domain; Region: NusA_N; pfam08529
866775003138	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
866775003139	RNA binding site [nucleotide binding]; other site
866775003140	homodimer interface [polypeptide binding]; other site
866775003141	NusA-like KH domain; Region: KH_5; pfam13184
866775003142	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
866775003143	G-X-X-G motif; other site
866775003144	ribosome maturation protein RimP; Reviewed; Region: PRK00092
866775003145	Sm and related proteins; Region: Sm_like; cl00259
866775003146	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
866775003147	putative oligomer interface [polypeptide binding]; other site
866775003148	putative RNA binding site [nucleotide binding]; other site
866775003149	Nitrogen regulatory protein P-II; Region: P-II; cl00412
866775003150	Nitrogen regulatory protein P-II; Region: P-II; smart00938
866775003151	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
866775003152	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
866775003153	Nitrogen regulatory protein P-II; Region: P-II; smart00938
866775003154	DNA polymerase III PolC; Validated; Region: polC; PRK00448
866775003155	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
866775003156	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
866775003157	generic binding surface II; other site
866775003158	generic binding surface I; other site
866775003159	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
866775003160	active site
866775003161	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866775003162	active site
866775003163	catalytic site [active]
866775003164	substrate binding site [chemical binding]; other site
866775003165	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
866775003166	RIP metalloprotease RseP; Region: TIGR00054
866775003167	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
866775003168	active site
866775003169	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
866775003170	protein binding site [polypeptide binding]; other site
866775003171	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
866775003172	putative substrate binding region [chemical binding]; other site
866775003173	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
866775003174	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
866775003175	catalytic residue [active]
866775003176	putative FPP diphosphate  binding site; other site
866775003177	putative FPP binding hydrophobic cleft; other site
866775003178	dimer interface [polypeptide binding]; other site
866775003179	putative IPP diphosphate binding site; other site
866775003180	ribosome recycling factor; Reviewed; Region: frr; PRK00083
866775003181	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
866775003182	hinge region; other site
866775003183	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
866775003184	putative nucleotide binding site [chemical binding]; other site
866775003185	uridine monophosphate binding site [chemical binding]; other site
866775003186	homohexameric interface [polypeptide binding]; other site
866775003187	elongation factor Ts; Provisional; Region: tsf; PRK09377
866775003188	UBA/TS-N domain; Region: UBA; pfam00627
866775003189	Elongation factor TS; Region: EF_TS; pfam00889
866775003190	Elongation factor TS; Region: EF_TS; pfam00889
866775003191	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
866775003192	rRNA interaction site [nucleotide binding]; other site
866775003193	S8 interaction site; other site
866775003194	putative laminin-1 binding site; other site
866775003195	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
866775003196	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
866775003197	active site
866775003198	substrate binding site [chemical binding]; other site
866775003199	trimer interface [polypeptide binding]; other site
866775003200	CoA binding site [chemical binding]; other site
866775003201	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
866775003202	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
866775003203	putative active site [active]
866775003204	putative metal binding site [ion binding]; other site
866775003205	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
866775003206	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
866775003207	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775003208	ATP binding site [chemical binding]; other site
866775003209	putative Mg++ binding site [ion binding]; other site
866775003210	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775003211	nucleotide binding region [chemical binding]; other site
866775003212	ATP-binding site [chemical binding]; other site
866775003213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775003214	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003215	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003216	Homeodomain-like domain; Region: HTH_32; pfam13565
866775003217	putative acyltransferase; Provisional; Region: PRK05790
866775003218	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
866775003219	dimer interface [polypeptide binding]; other site
866775003220	active site
866775003221	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
866775003222	Coenzyme A transferase; Region: CoA_trans; smart00882
866775003223	Coenzyme A transferase; Region: CoA_trans; cl17247
866775003224	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
866775003225	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
866775003226	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
866775003227	NAD(P) binding site [chemical binding]; other site
866775003228	homotetramer interface [polypeptide binding]; other site
866775003229	homodimer interface [polypeptide binding]; other site
866775003230	active site
866775003231	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775003232	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003233	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003234	Homeodomain-like domain; Region: HTH_32; pfam13565
866775003235	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
866775003236	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
866775003237	substrate binding site [chemical binding]; other site
866775003238	oxyanion hole (OAH) forming residues; other site
866775003239	trimer interface [polypeptide binding]; other site
866775003240	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
866775003241	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
866775003242	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866775003243	catalytic residue [active]
866775003244	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
866775003245	AzlC protein; Region: AzlC; cl00570
866775003246	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775003247	active site
866775003248	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
866775003249	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
866775003250	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
866775003251	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
866775003252	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
866775003253	putative acyl-acceptor binding pocket; other site
866775003254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
866775003255	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866775003256	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775003257	RNA binding surface [nucleotide binding]; other site
866775003258	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866775003259	active site
866775003260	lipoprotein signal peptidase; Provisional; Region: PRK14787
866775003261	lipoprotein signal peptidase; Provisional; Region: PRK14797
866775003262	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
866775003263	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
866775003264	RNA/DNA hybrid binding site [nucleotide binding]; other site
866775003265	active site
866775003266	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
866775003267	Family description; Region: UvrD_C_2; pfam13538
866775003268	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
866775003269	ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857
866775003270	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
866775003271	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
866775003272	active site
866775003273	catalytic triad [active]
866775003274	oxyanion hole [active]
866775003275	glycogen synthase; Provisional; Region: glgA; PRK00654
866775003276	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
866775003277	ADP-binding pocket [chemical binding]; other site
866775003278	homodimer interface [polypeptide binding]; other site
866775003279	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
866775003280	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866775003281	active site
866775003282	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
866775003283	dimer interface [polypeptide binding]; other site
866775003284	N-terminal domain interface [polypeptide binding]; other site
866775003285	sulfate 1 binding site; other site
866775003286	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
866775003287	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
866775003288	ligand binding site; other site
866775003289	oligomer interface; other site
866775003290	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
866775003291	dimer interface [polypeptide binding]; other site
866775003292	N-terminal domain interface [polypeptide binding]; other site
866775003293	sulfate 1 binding site; other site
866775003294	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
866775003295	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
866775003296	dimer interface [polypeptide binding]; other site
866775003297	active site
866775003298	metal binding site [ion binding]; metal-binding site
866775003299	glutathione binding site [chemical binding]; other site
866775003300	EDD domain protein, DegV family; Region: DegV; TIGR00762
866775003301	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866775003302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
866775003303	MarR family; Region: MarR_2; pfam12802
866775003304	MarR family; Region: MarR_2; cl17246
866775003305	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775003306	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775003307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775003308	Walker A/P-loop; other site
866775003309	ATP binding site [chemical binding]; other site
866775003310	Q-loop/lid; other site
866775003311	ABC transporter signature motif; other site
866775003312	Walker B; other site
866775003313	D-loop; other site
866775003314	H-loop/switch region; other site
866775003315	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775003316	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775003317	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866775003318	Walker A/P-loop; other site
866775003319	ATP binding site [chemical binding]; other site
866775003320	Q-loop/lid; other site
866775003321	ABC transporter signature motif; other site
866775003322	Walker B; other site
866775003323	D-loop; other site
866775003324	H-loop/switch region; other site
866775003325	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
866775003326	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
866775003327	Protein of unknown function (DUF464); Region: DUF464; pfam04327
866775003328	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
866775003329	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
866775003330	Ribosomal protein L21 leader
866775003331	dihydroorotase; Validated; Region: pyrC; PRK09357
866775003332	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866775003333	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
866775003334	active site
866775003335	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
866775003336	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866775003337	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866775003338	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
866775003339	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
866775003340	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
866775003341	catalytic site [active]
866775003342	subunit interface [polypeptide binding]; other site
866775003343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775003344	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
866775003345	Walker A/P-loop; other site
866775003346	ATP binding site [chemical binding]; other site
866775003347	Q-loop/lid; other site
866775003348	ABC transporter signature motif; other site
866775003349	Walker B; other site
866775003350	D-loop; other site
866775003351	H-loop/switch region; other site
866775003352	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775003353	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775003354	substrate binding pocket [chemical binding]; other site
866775003355	membrane-bound complex binding site; other site
866775003356	hinge residues; other site
866775003357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775003358	dimer interface [polypeptide binding]; other site
866775003359	conserved gate region; other site
866775003360	putative PBP binding loops; other site
866775003361	ABC-ATPase subunit interface; other site
866775003362	T-box leader
866775003363	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
866775003364	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866775003365	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866775003366	Walker A/P-loop; other site
866775003367	ATP binding site [chemical binding]; other site
866775003368	Q-loop/lid; other site
866775003369	ABC transporter signature motif; other site
866775003370	Walker B; other site
866775003371	D-loop; other site
866775003372	H-loop/switch region; other site
866775003373	aspartate kinase; Reviewed; Region: PRK09034
866775003374	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
866775003375	putative catalytic residues [active]
866775003376	putative nucleotide binding site [chemical binding]; other site
866775003377	putative aspartate binding site [chemical binding]; other site
866775003378	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
866775003379	allosteric regulatory residue; other site
866775003380	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
866775003381	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
866775003382	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
866775003383	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
866775003384	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
866775003385	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
866775003386	DNA binding residues [nucleotide binding]
866775003387	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
866775003388	G1 box; other site
866775003389	GTP/Mg2+ binding site [chemical binding]; other site
866775003390	Switch I region; other site
866775003391	G2 box; other site
866775003392	G3 box; other site
866775003393	Switch II region; other site
866775003394	G4 box; other site
866775003395	G5 box; other site
866775003396	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
866775003397	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
866775003398	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
866775003399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775003400	Walker A motif; other site
866775003401	ATP binding site [chemical binding]; other site
866775003402	Walker B motif; other site
866775003403	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
866775003404	trigger factor; Provisional; Region: tig; PRK01490
866775003405	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
866775003406	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
866775003407	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
866775003408	Transglycosylase; Region: Transgly; pfam00912
866775003409	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
866775003410	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
866775003411	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
866775003412	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
866775003413	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
866775003414	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
866775003415	ligand binding site [chemical binding]; other site
866775003416	active site
866775003417	UGI interface [polypeptide binding]; other site
866775003418	catalytic site [active]
866775003419	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775003420	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866775003421	active site
866775003422	motif I; other site
866775003423	motif II; other site
866775003424	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775003425	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866775003426	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
866775003427	active site
866775003428	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
866775003429	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775003430	motif II; other site
866775003431	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
866775003432	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775003433	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775003434	ABC transporter; Region: ABC_tran_2; pfam12848
866775003435	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775003436	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866775003437	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866775003438	Walker A/P-loop; other site
866775003439	ATP binding site [chemical binding]; other site
866775003440	Q-loop/lid; other site
866775003441	ABC transporter signature motif; other site
866775003442	Walker B; other site
866775003443	D-loop; other site
866775003444	H-loop/switch region; other site
866775003445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775003446	dimer interface [polypeptide binding]; other site
866775003447	conserved gate region; other site
866775003448	putative PBP binding loops; other site
866775003449	ABC-ATPase subunit interface; other site
866775003450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775003451	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866775003452	dimer interface [polypeptide binding]; other site
866775003453	conserved gate region; other site
866775003454	putative PBP binding loops; other site
866775003455	ABC-ATPase subunit interface; other site
866775003456	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
866775003457	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775003458	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775003459	substrate binding pocket [chemical binding]; other site
866775003460	membrane-bound complex binding site; other site
866775003461	hinge residues; other site
866775003462	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775003463	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775003464	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866775003465	Walker A/P-loop; other site
866775003466	ATP binding site [chemical binding]; other site
866775003467	Q-loop/lid; other site
866775003468	ABC transporter signature motif; other site
866775003469	Walker B; other site
866775003470	D-loop; other site
866775003471	H-loop/switch region; other site
866775003472	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866775003473	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866775003474	pantothenate kinase; Provisional; Region: PRK05439
866775003475	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
866775003476	ATP-binding site [chemical binding]; other site
866775003477	CoA-binding site [chemical binding]; other site
866775003478	Mg2+-binding site [ion binding]; other site
866775003479	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
866775003480	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
866775003481	active site 2 [active]
866775003482	Thioesterase-like superfamily; Region: 4HBT_2; pfam13279
866775003483	active site 2 [active]
866775003484	active site 1 [active]
866775003485	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
866775003486	Uncharacterized conserved protein [Function unknown]; Region: COG3937
866775003487	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
866775003488	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
866775003489	G1 box; other site
866775003490	G1 box; other site
866775003491	GTP/Mg2+ binding site [chemical binding]; other site
866775003492	GTP/Mg2+ binding site [chemical binding]; other site
866775003493	G2 box; other site
866775003494	Switch I region; other site
866775003495	G3 box; other site
866775003496	Switch II region; other site
866775003497	G4 box; other site
866775003498	G5 box; other site
866775003499	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
866775003500	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
866775003501	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
866775003502	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
866775003503	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
866775003504	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
866775003505	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
866775003506	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
866775003507	hinge; other site
866775003508	active site
866775003509	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775003510	active site
866775003511	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
866775003512	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
866775003513	dimer interface [polypeptide binding]; other site
866775003514	active site
866775003515	glycine-pyridoxal phosphate binding site [chemical binding]; other site
866775003516	folate binding site [chemical binding]; other site
866775003517	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
866775003518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775003519	S-adenosylmethionine binding site [chemical binding]; other site
866775003520	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
866775003521	peptide chain release factor 1; Validated; Region: prfA; PRK00591
866775003522	This domain is found in peptide chain release factors; Region: PCRF; smart00937
866775003523	RF-1 domain; Region: RF-1; pfam00472
866775003524	thymidine kinase; Provisional; Region: PRK04296
866775003525	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
866775003526	catalytic triad [active]
866775003527	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
866775003528	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866775003529	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
866775003530	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866775003531	Domain of unknown function DUF20; Region: UPF0118; pfam01594
866775003532	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
866775003533	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
866775003534	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
866775003535	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
866775003536	hexamer interface [polypeptide binding]; other site
866775003537	ligand binding site [chemical binding]; other site
866775003538	putative active site [active]
866775003539	NAD(P) binding site [chemical binding]; other site
866775003540	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
866775003541	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
866775003542	diaminopimelate decarboxylase; Region: lysA; TIGR01048
866775003543	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
866775003544	active site
866775003545	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866775003546	substrate binding site [chemical binding]; other site
866775003547	catalytic residues [active]
866775003548	dimer interface [polypeptide binding]; other site
866775003549	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
866775003550	PhoU domain; Region: PhoU; pfam01895
866775003551	PhoU domain; Region: PhoU; pfam01895
866775003552	benzoate transport; Region: 2A0115; TIGR00895
866775003553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866775003554	putative substrate translocation pore; other site
866775003555	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775003556	active site
866775003557	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
866775003558	active site
866775003559	dimer interface [polypeptide binding]; other site
866775003560	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775003561	catalytic core [active]
866775003562	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866775003563	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866775003564	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
866775003565	SmpB-tmRNA interface; other site
866775003566	ribonuclease R; Region: RNase_R; TIGR02063
866775003567	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
866775003568	RNB domain; Region: RNB; pfam00773
866775003569	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
866775003570	RNA binding site [nucleotide binding]; other site
866775003571	Esterase/lipase [General function prediction only]; Region: COG1647
866775003572	Preprotein translocase SecG subunit; Region: SecG; cl09123
866775003573	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866775003574	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
866775003575	putative ligand binding site [chemical binding]; other site
866775003576	putative NAD binding site [chemical binding]; other site
866775003577	putative catalytic site [active]
866775003578	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
866775003579	L-serine binding site [chemical binding]; other site
866775003580	ACT domain interface; other site
866775003581	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
866775003582	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
866775003583	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866775003584	catalytic residue [active]
866775003585	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
866775003586	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
866775003587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775003588	active site
866775003589	motif I; other site
866775003590	motif II; other site
866775003591	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775003592	enolase; Provisional; Region: eno; PRK00077
866775003593	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
866775003594	dimer interface [polypeptide binding]; other site
866775003595	metal binding site [ion binding]; metal-binding site
866775003596	substrate binding pocket [chemical binding]; other site
866775003597	triosephosphate isomerase; Provisional; Region: PRK14565
866775003598	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
866775003599	substrate binding site [chemical binding]; other site
866775003600	dimer interface [polypeptide binding]; other site
866775003601	catalytic triad [active]
866775003602	Phosphoglycerate kinase; Region: PGK; pfam00162
866775003603	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
866775003604	substrate binding site [chemical binding]; other site
866775003605	hinge regions; other site
866775003606	ADP binding site [chemical binding]; other site
866775003607	catalytic site [active]
866775003608	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
866775003609	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
866775003610	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
866775003611	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
866775003612	Predicted transcriptional regulator [Transcription]; Region: COG3388
866775003613	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
866775003614	Clp protease; Region: CLP_protease; pfam00574
866775003615	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
866775003616	oligomer interface [polypeptide binding]; other site
866775003617	active site residues [active]
866775003618	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
866775003619	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866775003620	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775003621	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003622	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003623	Homeodomain-like domain; Region: HTH_32; pfam13565
866775003624	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
866775003625	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775003626	active site
866775003627	phosphorylation site [posttranslational modification]
866775003628	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
866775003629	active site
866775003630	P-loop; other site
866775003631	phosphorylation site [posttranslational modification]
866775003632	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
866775003633	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
866775003634	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
866775003635	putative substrate binding site [chemical binding]; other site
866775003636	putative ATP binding site [chemical binding]; other site
866775003637	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
866775003638	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
866775003639	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
866775003640	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
866775003641	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
866775003642	active site
866775003643	dimer interface [polypeptide binding]; other site
866775003644	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
866775003645	dimer interface [polypeptide binding]; other site
866775003646	active site
866775003647	general stress protein 13; Validated; Region: PRK08059
866775003648	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
866775003649	RNA binding site [nucleotide binding]; other site
866775003650	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
866775003651	active site
866775003652	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
866775003653	active site
866775003654	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
866775003655	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866775003656	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775003657	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
866775003658	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
866775003659	aspartate aminotransferase; Provisional; Region: PRK05764
866775003660	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866775003661	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775003662	homodimer interface [polypeptide binding]; other site
866775003663	catalytic residue [active]
866775003664	DnaQ family exonuclease/DinG family helicase, putative; Region: dinG_rel; TIGR01407
866775003665	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
866775003666	active site
866775003667	catalytic site [active]
866775003668	substrate binding site [chemical binding]; other site
866775003669	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
866775003670	dihydrodipicolinate reductase; Provisional; Region: PRK00048
866775003671	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
866775003672	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
866775003673	TPR repeat; Region: TPR_11; pfam13414
866775003674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866775003675	binding surface
866775003676	TPR motif; other site
866775003677	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
866775003678	IHF - DNA interface [nucleotide binding]; other site
866775003679	IHF dimer interface [polypeptide binding]; other site
866775003680	GTP-binding protein Der; Reviewed; Region: PRK00093
866775003681	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
866775003682	G1 box; other site
866775003683	GTP/Mg2+ binding site [chemical binding]; other site
866775003684	Switch I region; other site
866775003685	G2 box; other site
866775003686	Switch II region; other site
866775003687	G3 box; other site
866775003688	G4 box; other site
866775003689	G5 box; other site
866775003690	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
866775003691	G1 box; other site
866775003692	GTP/Mg2+ binding site [chemical binding]; other site
866775003693	Switch I region; other site
866775003694	G2 box; other site
866775003695	G3 box; other site
866775003696	Switch II region; other site
866775003697	G4 box; other site
866775003698	G5 box; other site
866775003699	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
866775003700	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
866775003701	RNA binding site [nucleotide binding]; other site
866775003702	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
866775003703	RNA binding site [nucleotide binding]; other site
866775003704	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
866775003705	RNA binding site [nucleotide binding]; other site
866775003706	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
866775003707	RNA binding site [nucleotide binding]; other site
866775003708	cytidylate kinase; Provisional; Region: cmk; PRK00023
866775003709	AAA domain; Region: AAA_17; pfam13207
866775003710	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
866775003711	CMP-binding site; other site
866775003712	The sites determining sugar specificity; other site
866775003713	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775003714	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
866775003715	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775003716	ATP binding site [chemical binding]; other site
866775003717	putative Mg++ binding site [ion binding]; other site
866775003718	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775003719	nucleotide binding region [chemical binding]; other site
866775003720	ATP-binding site [chemical binding]; other site
866775003721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
866775003722	Predicted membrane protein [Function unknown]; Region: COG3601
866775003723	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
866775003724	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
866775003725	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775003726	RNA binding surface [nucleotide binding]; other site
866775003727	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
866775003728	active site
866775003729	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
866775003730	NAD-dependent deacetylase; Provisional; Region: PRK00481
866775003731	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
866775003732	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
866775003733	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
866775003734	active site
866775003735	Int/Topo IB signature motif; other site
866775003736	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
866775003737	S1 domain; Region: S1_2; pfam13509
866775003738	pyruvate kinase; Provisional; Region: PRK06354
866775003739	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
866775003740	domain interfaces; other site
866775003741	active site
866775003742	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
866775003743	6-phosphofructokinase; Provisional; Region: PRK03202
866775003744	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
866775003745	active site
866775003746	ADP/pyrophosphate binding site [chemical binding]; other site
866775003747	dimerization interface [polypeptide binding]; other site
866775003748	allosteric effector site; other site
866775003749	fructose-1,6-bisphosphate binding site; other site
866775003750	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
866775003751	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
866775003752	active site
866775003753	PHP Thumb interface [polypeptide binding]; other site
866775003754	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
866775003755	generic binding surface II; other site
866775003756	generic binding surface I; other site
866775003757	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
866775003758	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775003759	Walker A motif; other site
866775003760	ATP binding site [chemical binding]; other site
866775003761	Walker B motif; other site
866775003762	arginine finger; other site
866775003763	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
866775003764	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
866775003765	RuvA N terminal domain; Region: RuvA_N; pfam01330
866775003766	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
866775003767	methionine sulfoxide reductase B; Provisional; Region: PRK00222
866775003768	SelR domain; Region: SelR; pfam01641
866775003769	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
866775003770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775003771	ATP binding site [chemical binding]; other site
866775003772	Mg2+ binding site [ion binding]; other site
866775003773	G-X-G motif; other site
866775003774	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
866775003775	ATP binding site [chemical binding]; other site
866775003776	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
866775003777	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
866775003778	MutS domain I; Region: MutS_I; pfam01624
866775003779	MutS domain II; Region: MutS_II; pfam05188
866775003780	MutS domain III; Region: MutS_III; pfam05192
866775003781	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
866775003782	Walker A/P-loop; other site
866775003783	ATP binding site [chemical binding]; other site
866775003784	Q-loop/lid; other site
866775003785	ABC transporter signature motif; other site
866775003786	Walker B; other site
866775003787	D-loop; other site
866775003788	H-loop/switch region; other site
866775003789	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775003790	catalytic core [active]
866775003791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866775003792	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866775003793	phosphodiesterase; Provisional; Region: PRK12704
866775003794	KH domain; Region: KH_1; pfam00013
866775003795	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866775003796	Zn2+ binding site [ion binding]; other site
866775003797	Mg2+ binding site [ion binding]; other site
866775003798	recombinase A; Provisional; Region: recA; PRK09354
866775003799	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
866775003800	hexamer interface [polypeptide binding]; other site
866775003801	Walker A motif; other site
866775003802	ATP binding site [chemical binding]; other site
866775003803	Walker B motif; other site
866775003804	competence damage-inducible protein A; Provisional; Region: PRK00549
866775003805	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
866775003806	putative MPT binding site; other site
866775003807	Competence-damaged protein; Region: CinA; pfam02464
866775003808	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
866775003809	Acylphosphatase; Region: Acylphosphatase; pfam00708
866775003810	OxaA-like protein precursor; Provisional; Region: PRK02463
866775003811	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
866775003812	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775003813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775003814	active site
866775003815	phosphorylation site [posttranslational modification]
866775003816	intermolecular recognition site; other site
866775003817	dimerization interface [polypeptide binding]; other site
866775003818	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775003819	DNA binding site [nucleotide binding]
866775003820	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
866775003821	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
866775003822	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
866775003823	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
866775003824	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
866775003825	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
866775003826	Ligand Binding Site [chemical binding]; other site
866775003827	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
866775003828	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
866775003829	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
866775003830	catalytic residue [active]
866775003831	septation ring formation regulator EzrA; Provisional; Region: PRK04778
866775003832	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
866775003833	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
866775003834	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775003835	RNA binding surface [nucleotide binding]; other site
866775003836	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
866775003837	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
866775003838	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
866775003839	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
866775003840	dimer interface [polypeptide binding]; other site
866775003841	ADP-ribose binding site [chemical binding]; other site
866775003842	active site
866775003843	nudix motif; other site
866775003844	metal binding site [ion binding]; metal-binding site
866775003845	putative transposase OrfB; Reviewed; Region: PHA02517
866775003846	HTH-like domain; Region: HTH_21; pfam13276
866775003847	Integrase core domain; Region: rve; pfam00665
866775003848	Integrase core domain; Region: rve_2; pfam13333
866775003849	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775003850	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003851	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775003852	Homeodomain-like domain; Region: HTH_32; pfam13565
866775003853	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
866775003854	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866775003855	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775003856	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866775003857	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
866775003858	DNA-binding site [nucleotide binding]; DNA binding site
866775003859	RNA-binding motif; other site
866775003860	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
866775003861	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866775003862	active site
866775003863	HIGH motif; other site
866775003864	nucleotide binding site [chemical binding]; other site
866775003865	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
866775003866	active site
866775003867	KMSKS motif; other site
866775003868	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
866775003869	tRNA binding surface [nucleotide binding]; other site
866775003870	anticodon binding site; other site
866775003871	T-box leader
866775003872	DivIVA protein; Region: DivIVA; pfam05103
866775003873	DivIVA domain; Region: DivI1A_domain; TIGR03544
866775003874	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
866775003875	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775003876	RNA binding surface [nucleotide binding]; other site
866775003877	YGGT family; Region: YGGT; pfam02325
866775003878	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
866775003879	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866775003880	catalytic residue [active]
866775003881	cell division protein FtsZ; Validated; Region: PRK09330
866775003882	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
866775003883	nucleotide binding site [chemical binding]; other site
866775003884	SulA interaction site; other site
866775003885	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
866775003886	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866775003887	nucleotide binding site [chemical binding]; other site
866775003888	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
866775003889	Cell division protein FtsA; Region: FtsA; pfam14450
866775003890	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
866775003891	Cell division protein FtsQ; Region: FtsQ; pfam03799
866775003892	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
866775003893	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
866775003894	active site
866775003895	homodimer interface [polypeptide binding]; other site
866775003896	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
866775003897	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
866775003898	NAD(P) binding pocket [chemical binding]; other site
866775003899	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866775003900	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
866775003901	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866775003902	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
866775003903	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
866775003904	Mg++ binding site [ion binding]; other site
866775003905	putative catalytic motif [active]
866775003906	putative substrate binding site [chemical binding]; other site
866775003907	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
866775003908	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866775003909	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866775003910	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
866775003911	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
866775003912	Cell division protein FtsL; Region: FtsL; cl11433
866775003913	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
866775003914	MraW methylase family; Region: Methyltransf_5; pfam01795
866775003915	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
866775003916	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
866775003917	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
866775003918	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
866775003919	hypothetical protein; Provisional; Region: PRK13670
866775003920	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
866775003921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775003922	S-adenosylmethionine binding site [chemical binding]; other site
866775003923	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
866775003924	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
866775003925	Zn2+ binding site [ion binding]; other site
866775003926	Mg2+ binding site [ion binding]; other site
866775003927	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
866775003928	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
866775003929	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
866775003930	active site
866775003931	(T/H)XGH motif; other site
866775003932	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
866775003933	GTPase YqeH; Provisional; Region: PRK13796
866775003934	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
866775003935	GTP/Mg2+ binding site [chemical binding]; other site
866775003936	G4 box; other site
866775003937	G5 box; other site
866775003938	G1 box; other site
866775003939	Switch I region; other site
866775003940	G2 box; other site
866775003941	G3 box; other site
866775003942	Switch II region; other site
866775003943	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
866775003944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775003945	active site
866775003946	motif I; other site
866775003947	motif II; other site
866775003948	homoserine kinase; Provisional; Region: PRK01212
866775003949	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866775003950	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
866775003951	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
866775003952	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
866775003953	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
866775003954	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
866775003955	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
866775003956	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
866775003957	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
866775003958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
866775003959	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
866775003960	putative ADP-binding pocket [chemical binding]; other site
866775003961	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
866775003962	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
866775003963	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
866775003964	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
866775003965	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
866775003966	dimerization domain swap beta strand [polypeptide binding]; other site
866775003967	regulatory protein interface [polypeptide binding]; other site
866775003968	active site
866775003969	regulatory phosphorylation site [posttranslational modification]; other site
866775003970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775003971	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
866775003972	Walker A motif; other site
866775003973	ATP binding site [chemical binding]; other site
866775003974	Walker B motif; other site
866775003975	arginine finger; other site
866775003976	UvrB/uvrC motif; Region: UVR; pfam02151
866775003977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775003978	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
866775003979	Walker A motif; other site
866775003980	ATP binding site [chemical binding]; other site
866775003981	Walker B motif; other site
866775003982	arginine finger; other site
866775003983	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866775003984	Transposase; Region: DEDD_Tnp_IS110; pfam01548
866775003985	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
866775003986	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
866775003987	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
866775003988	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
866775003989	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
866775003990	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866775003991	active site
866775003992	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
866775003993	G2 box; other site
866775003994	Switch I region; other site
866775003995	G3 box; other site
866775003996	Switch II region; other site
866775003997	GTP/Mg2+ binding site [chemical binding]; other site
866775003998	G4 box; other site
866775003999	G5 box; other site
866775004000	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
866775004001	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866775004002	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866775004003	Walker A/P-loop; other site
866775004004	ATP binding site [chemical binding]; other site
866775004005	Q-loop/lid; other site
866775004006	ABC transporter signature motif; other site
866775004007	Walker B; other site
866775004008	D-loop; other site
866775004009	H-loop/switch region; other site
866775004010	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775004011	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775004012	substrate binding pocket [chemical binding]; other site
866775004013	membrane-bound complex binding site; other site
866775004014	hinge residues; other site
866775004015	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866775004016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775004017	dimer interface [polypeptide binding]; other site
866775004018	conserved gate region; other site
866775004019	putative PBP binding loops; other site
866775004020	ABC-ATPase subunit interface; other site
866775004021	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
866775004022	V-type ATP synthase subunit B; Provisional; Region: PRK04196
866775004023	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866775004024	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
866775004025	Walker A motif homologous position; other site
866775004026	Walker B motif; other site
866775004027	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866775004028	V-type ATP synthase subunit A; Provisional; Region: PRK04192
866775004029	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
866775004030	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
866775004031	Walker A motif/ATP binding site; other site
866775004032	Walker B motif; other site
866775004033	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
866775004034	V-type ATP synthase subunit F; Provisional; Region: PRK01395
866775004035	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
866775004036	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
866775004037	V-type ATP synthase subunit K; Validated; Region: PRK06558
866775004038	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
866775004039	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
866775004040	V-type ATP synthase subunit I; Validated; Region: PRK05771
866775004041	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
866775004042	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
866775004043	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775004044	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
866775004045	Coenzyme A binding pocket [chemical binding]; other site
866775004046	Homoserine O-succinyltransferase; Region: HTS; pfam04204
866775004047	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
866775004048	proposed active site lysine [active]
866775004049	conserved cys residue [active]
866775004050	T-box leader
866775004051	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
866775004052	MgtE intracellular N domain; Region: MgtE_N; pfam03448
866775004053	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
866775004054	Divalent cation transporter; Region: MgtE; pfam01769
866775004055	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
866775004056	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775004057	RNA binding surface [nucleotide binding]; other site
866775004058	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
866775004059	active site
866775004060	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
866775004061	ATP-NAD kinase; Region: NAD_kinase; pfam01513
866775004062	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
866775004063	putative active site [active]
866775004064	putative metal binding residues [ion binding]; other site
866775004065	signature motif; other site
866775004066	putative triphosphate binding site [ion binding]; other site
866775004067	Thioredoxin; Region: Thioredoxin_5; pfam13743
866775004068	Competence protein CoiA-like family; Region: CoiA; cl11541
866775004069	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
866775004070	ArsC family; Region: ArsC; pfam03960
866775004071	putative catalytic residues [active]
866775004072	thiol/disulfide switch; other site
866775004073	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
866775004074	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
866775004075	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775004076	Coenzyme A binding pocket [chemical binding]; other site
866775004077	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
866775004078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775004079	dimer interface [polypeptide binding]; other site
866775004080	conserved gate region; other site
866775004081	ABC-ATPase subunit interface; other site
866775004082	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
866775004083	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
866775004084	Walker A/P-loop; other site
866775004085	ATP binding site [chemical binding]; other site
866775004086	Q-loop/lid; other site
866775004087	ABC transporter signature motif; other site
866775004088	Walker B; other site
866775004089	D-loop; other site
866775004090	H-loop/switch region; other site
866775004091	NIL domain; Region: NIL; pfam09383
866775004092	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
866775004093	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
866775004094	dimerization interface [polypeptide binding]; other site
866775004095	DPS ferroxidase diiron center [ion binding]; other site
866775004096	ion pore; other site
866775004097	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
866775004098	23S rRNA binding site [nucleotide binding]; other site
866775004099	L21 binding site [polypeptide binding]; other site
866775004100	L13 binding site [polypeptide binding]; other site
866775004101	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
866775004102	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
866775004103	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
866775004104	Ribosomal protein L20 leader
866775004105	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
866775004106	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
866775004107	metal binding site [ion binding]; metal-binding site
866775004108	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
866775004109	putative ADP-ribose binding site [chemical binding]; other site
866775004110	putative active site [active]
866775004111	Predicted membrane protein [Function unknown]; Region: COG2246
866775004112	GtrA-like protein; Region: GtrA; pfam04138
866775004113	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
866775004114	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
866775004115	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
866775004116	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
866775004117	active site
866775004118	dimer interface [polypeptide binding]; other site
866775004119	motif 1; other site
866775004120	motif 2; other site
866775004121	motif 3; other site
866775004122	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
866775004123	anticodon binding site; other site
866775004124	T-box leader
866775004125	primosomal protein DnaI; Reviewed; Region: PRK08939
866775004126	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
866775004127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004128	Walker A motif; other site
866775004129	ATP binding site [chemical binding]; other site
866775004130	Walker B motif; other site
866775004131	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
866775004132	ATP cone domain; Region: ATP-cone; pfam03477
866775004133	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
866775004134	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
866775004135	CoA-binding site [chemical binding]; other site
866775004136	ATP-binding [chemical binding]; other site
866775004137	DNA polymerase I; Provisional; Region: PRK05755
866775004138	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
866775004139	active site
866775004140	metal binding site 1 [ion binding]; metal-binding site
866775004141	putative 5' ssDNA interaction site; other site
866775004142	metal binding site 3; metal-binding site
866775004143	metal binding site 2 [ion binding]; metal-binding site
866775004144	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
866775004145	putative DNA binding site [nucleotide binding]; other site
866775004146	putative metal binding site [ion binding]; other site
866775004147	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
866775004148	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
866775004149	active site
866775004150	DNA binding site [nucleotide binding]
866775004151	catalytic site [active]
866775004152	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
866775004153	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004154	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866775004155	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004156	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004157	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866775004158	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004159	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004160	Methyltransferase domain; Region: Methyltransf_31; pfam13847
866775004161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
866775004162	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
866775004163	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
866775004164	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
866775004165	glutaminase active site [active]
866775004166	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
866775004167	dimer interface [polypeptide binding]; other site
866775004168	active site
866775004169	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
866775004170	dimer interface [polypeptide binding]; other site
866775004171	active site
866775004172	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
866775004173	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
866775004174	active site
866775004175	HIGH motif; other site
866775004176	nucleotide binding site [chemical binding]; other site
866775004177	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
866775004178	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
866775004179	active site
866775004180	KMSKS motif; other site
866775004181	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
866775004182	tRNA binding surface [nucleotide binding]; other site
866775004183	anticodon binding site; other site
866775004184	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
866775004185	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
866775004186	active site
866775004187	DNA binding site [nucleotide binding]
866775004188	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866775004189	active site residue [active]
866775004190	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
866775004191	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
866775004192	nucleotide binding site [chemical binding]; other site
866775004193	Rhomboid family; Region: Rhomboid; pfam01694
866775004194	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
866775004195	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
866775004196	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
866775004197	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
866775004198	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
866775004199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775004200	S-adenosylmethionine binding site [chemical binding]; other site
866775004201	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
866775004202	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
866775004203	DEAD-like helicases superfamily; Region: DEXDc; smart00487
866775004204	ATP binding site [chemical binding]; other site
866775004205	putative Mg++ binding site [ion binding]; other site
866775004206	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775004207	nucleotide binding region [chemical binding]; other site
866775004208	ATP-binding site [chemical binding]; other site
866775004209	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
866775004210	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
866775004211	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
866775004212	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
866775004213	DHH family; Region: DHH; pfam01368
866775004214	DHHA1 domain; Region: DHHA1; pfam02272
866775004215	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
866775004216	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866775004217	DNA-binding site [nucleotide binding]; DNA binding site
866775004218	DRTGG domain; Region: DRTGG; pfam07085
866775004219	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
866775004220	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
866775004221	active site
866775004222	DNA polymerase IV; Validated; Region: PRK02406
866775004223	DNA binding site [nucleotide binding]
866775004224	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
866775004225	Preprotein translocase subunit; Region: YajC; pfam02699
866775004226	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
866775004227	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
866775004228	putative transposase OrfB; Reviewed; Region: PHA02517
866775004229	HTH-like domain; Region: HTH_21; pfam13276
866775004230	Integrase core domain; Region: rve; pfam00665
866775004231	Integrase core domain; Region: rve_2; pfam13333
866775004232	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775004233	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775004234	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775004235	Homeodomain-like domain; Region: HTH_32; pfam13565
866775004236	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
866775004237	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
866775004238	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
866775004239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004240	Walker A motif; other site
866775004241	ATP binding site [chemical binding]; other site
866775004242	Walker B motif; other site
866775004243	arginine finger; other site
866775004244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004245	Walker A motif; other site
866775004246	ATP binding site [chemical binding]; other site
866775004247	Walker B motif; other site
866775004248	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866775004249	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
866775004250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004251	Walker A motif; other site
866775004252	ATP binding site [chemical binding]; other site
866775004253	Walker B motif; other site
866775004254	arginine finger; other site
866775004255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004256	Walker A motif; other site
866775004257	ATP binding site [chemical binding]; other site
866775004258	Walker B motif; other site
866775004259	arginine finger; other site
866775004260	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866775004261	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
866775004262	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866775004263	E3 interaction surface; other site
866775004264	lipoyl attachment site [posttranslational modification]; other site
866775004265	e3 binding domain; Region: E3_binding; pfam02817
866775004266	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866775004267	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
866775004268	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
866775004269	alpha subunit interface [polypeptide binding]; other site
866775004270	TPP binding site [chemical binding]; other site
866775004271	heterodimer interface [polypeptide binding]; other site
866775004272	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866775004273	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
866775004274	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
866775004275	tetramer interface [polypeptide binding]; other site
866775004276	TPP-binding site [chemical binding]; other site
866775004277	heterodimer interface [polypeptide binding]; other site
866775004278	phosphorylation loop region [posttranslational modification]
866775004279	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
866775004280	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
866775004281	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775004282	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866775004283	Transcriptional regulator [Transcription]; Region: LysR; COG0583
866775004284	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
866775004285	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
866775004286	dimerization interface [polypeptide binding]; other site
866775004287	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
866775004288	putative active site [active]
866775004289	putative catalytic site [active]
866775004290	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
866775004291	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
866775004292	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
866775004293	RimM N-terminal domain; Region: RimM; pfam01782
866775004294	PRC-barrel domain; Region: PRC; pfam05239
866775004295	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
866775004296	KH domain; Region: KH_4; pfam13083
866775004297	G-X-X-G motif; other site
866775004298	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
866775004299	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
866775004300	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775004301	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775004302	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
866775004303	Walker A/P-loop; other site
866775004304	ATP binding site [chemical binding]; other site
866775004305	Q-loop/lid; other site
866775004306	ABC transporter signature motif; other site
866775004307	Walker B; other site
866775004308	D-loop; other site
866775004309	H-loop/switch region; other site
866775004310	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
866775004311	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
866775004312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775004313	Walker A/P-loop; other site
866775004314	ATP binding site [chemical binding]; other site
866775004315	Q-loop/lid; other site
866775004316	ABC transporter signature motif; other site
866775004317	Walker B; other site
866775004318	D-loop; other site
866775004319	H-loop/switch region; other site
866775004320	FemAB family; Region: FemAB; pfam02388
866775004321	signal recognition particle protein; Provisional; Region: PRK10867
866775004322	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
866775004323	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866775004324	P loop; other site
866775004325	GTP binding site [chemical binding]; other site
866775004326	Signal peptide binding domain; Region: SRP_SPB; pfam02978
866775004327	putative DNA-binding protein; Validated; Region: PRK00118
866775004328	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
866775004329	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
866775004330	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
866775004331	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
866775004332	P loop; other site
866775004333	GTP binding site [chemical binding]; other site
866775004334	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775004335	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866775004336	active site
866775004337	motif I; other site
866775004338	motif II; other site
866775004339	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775004340	motif II; other site
866775004341	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775004342	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
866775004343	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
866775004344	Walker A/P-loop; other site
866775004345	ATP binding site [chemical binding]; other site
866775004346	Q-loop/lid; other site
866775004347	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
866775004348	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
866775004349	ABC transporter signature motif; other site
866775004350	Walker B; other site
866775004351	D-loop; other site
866775004352	H-loop/switch region; other site
866775004353	Phosphopantetheine attachment site; Region: PP-binding; cl09936
866775004354	putative phosphate acyltransferase; Provisional; Region: PRK05331
866775004355	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
866775004356	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
866775004357	generic binding surface II; other site
866775004358	ssDNA binding site; other site
866775004359	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775004360	ATP binding site [chemical binding]; other site
866775004361	putative Mg++ binding site [ion binding]; other site
866775004362	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775004363	nucleotide binding region [chemical binding]; other site
866775004364	ATP-binding site [chemical binding]; other site
866775004365	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
866775004366	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
866775004367	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
866775004368	DAK2 domain; Region: Dak2; pfam02734
866775004369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
866775004370	Thiamine pyrophosphokinase; Region: TPK; cd07995
866775004371	active site
866775004372	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
866775004373	dimerization interface [polypeptide binding]; other site
866775004374	thiamine binding site [chemical binding]; other site
866775004375	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
866775004376	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
866775004377	substrate binding site [chemical binding]; other site
866775004378	hexamer interface [polypeptide binding]; other site
866775004379	metal binding site [ion binding]; metal-binding site
866775004380	GTPase RsgA; Reviewed; Region: PRK00098
866775004381	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
866775004382	RNA binding site [nucleotide binding]; other site
866775004383	homodimer interface [polypeptide binding]; other site
866775004384	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
866775004385	GTPase/Zn-binding domain interface [polypeptide binding]; other site
866775004386	GTP/Mg2+ binding site [chemical binding]; other site
866775004387	G4 box; other site
866775004388	G5 box; other site
866775004389	G1 box; other site
866775004390	Switch I region; other site
866775004391	G2 box; other site
866775004392	G3 box; other site
866775004393	Switch II region; other site
866775004394	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
866775004395	Catalytic domain of Protein Kinases; Region: PKc; cd00180
866775004396	active site
866775004397	ATP binding site [chemical binding]; other site
866775004398	substrate binding site [chemical binding]; other site
866775004399	activation loop (A-loop); other site
866775004400	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866775004401	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
866775004402	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866775004403	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
866775004404	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
866775004405	active site
866775004406	16S rRNA methyltransferase B; Provisional; Region: PRK14902
866775004407	NusB family; Region: NusB; pfam01029
866775004408	putative RNA binding site [nucleotide binding]; other site
866775004409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775004410	S-adenosylmethionine binding site [chemical binding]; other site
866775004411	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
866775004412	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
866775004413	putative active site [active]
866775004414	substrate binding site [chemical binding]; other site
866775004415	putative cosubstrate binding site; other site
866775004416	catalytic site [active]
866775004417	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
866775004418	substrate binding site [chemical binding]; other site
866775004419	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
866775004420	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775004421	ATP binding site [chemical binding]; other site
866775004422	putative Mg++ binding site [ion binding]; other site
866775004423	UL49 family; Region: Herpes_UL49_1; pfam03117
866775004424	helicase superfamily c-terminal domain; Region: HELICc; smart00490
866775004425	ATP-binding site [chemical binding]; other site
866775004426	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
866775004427	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
866775004428	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
866775004429	putative active site [active]
866775004430	catalytic site [active]
866775004431	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
866775004432	putative active site [active]
866775004433	catalytic site [active]
866775004434	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491
866775004435	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
866775004436	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866775004437	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
866775004438	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
866775004439	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
866775004440	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
866775004441	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
866775004442	RNase E interface [polypeptide binding]; other site
866775004443	trimer interface [polypeptide binding]; other site
866775004444	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
866775004445	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
866775004446	RNase E interface [polypeptide binding]; other site
866775004447	trimer interface [polypeptide binding]; other site
866775004448	active site
866775004449	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
866775004450	putative nucleic acid binding region [nucleotide binding]; other site
866775004451	G-X-X-G motif; other site
866775004452	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
866775004453	RNA binding site [nucleotide binding]; other site
866775004454	domain interface; other site
866775004455	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
866775004456	16S/18S rRNA binding site [nucleotide binding]; other site
866775004457	S13e-L30e interaction site [polypeptide binding]; other site
866775004458	25S rRNA binding site [nucleotide binding]; other site
866775004459	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
866775004460	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
866775004461	active site
866775004462	excinuclease ABC subunit B; Provisional; Region: PRK05298
866775004463	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775004464	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775004465	nucleotide binding region [chemical binding]; other site
866775004466	ATP-binding site [chemical binding]; other site
866775004467	Ultra-violet resistance protein B; Region: UvrB; pfam12344
866775004468	UvrB/uvrC motif; Region: UVR; pfam02151
866775004469	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
866775004470	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
866775004471	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
866775004472	Competence protein; Region: Competence; pfam03772
866775004473	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
866775004474	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
866775004475	SLBB domain; Region: SLBB; pfam10531
866775004476	comEA protein; Region: comE; TIGR01259
866775004477	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
866775004478	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
866775004479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775004480	S-adenosylmethionine binding site [chemical binding]; other site
866775004481	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902
866775004482	pyruvate carboxylase; Reviewed; Region: PRK12999
866775004483	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
866775004484	ATP-grasp domain; Region: ATP-grasp_4; cl17255
866775004485	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
866775004486	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
866775004487	active site
866775004488	catalytic residues [active]
866775004489	metal binding site [ion binding]; metal-binding site
866775004490	homodimer binding site [polypeptide binding]; other site
866775004491	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
866775004492	carboxyltransferase (CT) interaction site; other site
866775004493	biotinylation site [posttranslational modification]; other site
866775004494	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
866775004495	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
866775004496	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
866775004497	G1 box; other site
866775004498	putative GEF interaction site [polypeptide binding]; other site
866775004499	GTP/Mg2+ binding site [chemical binding]; other site
866775004500	Switch I region; other site
866775004501	G2 box; other site
866775004502	G3 box; other site
866775004503	Switch II region; other site
866775004504	G4 box; other site
866775004505	G5 box; other site
866775004506	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
866775004507	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
866775004508	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
866775004509	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
866775004510	active site
866775004511	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
866775004512	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
866775004513	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775004514	RNA binding surface [nucleotide binding]; other site
866775004515	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
866775004516	active site
866775004517	uracil binding [chemical binding]; other site
866775004518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775004519	dimer interface [polypeptide binding]; other site
866775004520	conserved gate region; other site
866775004521	putative PBP binding loops; other site
866775004522	ABC-ATPase subunit interface; other site
866775004523	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866775004524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775004525	dimer interface [polypeptide binding]; other site
866775004526	conserved gate region; other site
866775004527	putative PBP binding loops; other site
866775004528	ABC-ATPase subunit interface; other site
866775004529	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775004530	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775004531	substrate binding pocket [chemical binding]; other site
866775004532	membrane-bound complex binding site; other site
866775004533	hinge residues; other site
866775004534	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
866775004535	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
866775004536	Walker A/P-loop; other site
866775004537	ATP binding site [chemical binding]; other site
866775004538	Q-loop/lid; other site
866775004539	ABC transporter signature motif; other site
866775004540	Walker B; other site
866775004541	D-loop; other site
866775004542	H-loop/switch region; other site
866775004543	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775004544	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775004545	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775004546	Homeodomain-like domain; Region: HTH_32; pfam13565
866775004547	putative transposase OrfB; Reviewed; Region: PHA02517
866775004548	HTH-like domain; Region: HTH_21; pfam13276
866775004549	Integrase core domain; Region: rve; pfam00665
866775004550	Integrase core domain; Region: rve_2; pfam13333
866775004551	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
866775004552	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775004553	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866775004554	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
866775004555	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866775004556	E3 interaction surface; other site
866775004557	lipoyl attachment site [posttranslational modification]; other site
866775004558	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866775004559	E3 interaction surface; other site
866775004560	lipoyl attachment site [posttranslational modification]; other site
866775004561	e3 binding domain; Region: E3_binding; pfam02817
866775004562	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866775004563	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
866775004564	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
866775004565	alpha subunit interface [polypeptide binding]; other site
866775004566	TPP binding site [chemical binding]; other site
866775004567	heterodimer interface [polypeptide binding]; other site
866775004568	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866775004569	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
866775004570	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
866775004571	TPP-binding site [chemical binding]; other site
866775004572	tetramer interface [polypeptide binding]; other site
866775004573	heterodimer interface [polypeptide binding]; other site
866775004574	phosphorylation loop region [posttranslational modification]
866775004575	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
866775004576	active site
866775004577	catalytic residues [active]
866775004578	metal binding site [ion binding]; metal-binding site
866775004579	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
866775004580	Flavoprotein; Region: Flavoprotein; pfam02441
866775004581	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
866775004582	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
866775004583	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
866775004584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775004585	catalytic residue [active]
866775004586	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
866775004587	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
866775004588	5S rRNA interface [nucleotide binding]; other site
866775004589	CTC domain interface [polypeptide binding]; other site
866775004590	L16 interface [polypeptide binding]; other site
866775004591	Predicted membrane protein [Function unknown]; Region: COG2855
866775004592	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
866775004593	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
866775004594	catalytic residues [active]
866775004595	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
866775004596	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
866775004597	ligand binding site [chemical binding]; other site
866775004598	flexible hinge region; other site
866775004599	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
866775004600	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
866775004601	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
866775004602	Putative esterase; Region: Esterase; pfam00756
866775004603	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
866775004604	homodimer interface [polypeptide binding]; other site
866775004605	catalytic residues [active]
866775004606	NAD binding site [chemical binding]; other site
866775004607	substrate binding pocket [chemical binding]; other site
866775004608	flexible flap; other site
866775004609	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
866775004610	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
866775004611	dimer interface [polypeptide binding]; other site
866775004612	active site
866775004613	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
866775004614	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866775004615	Walker A/P-loop; other site
866775004616	ATP binding site [chemical binding]; other site
866775004617	Q-loop/lid; other site
866775004618	ABC transporter signature motif; other site
866775004619	Walker B; other site
866775004620	D-loop; other site
866775004621	H-loop/switch region; other site
866775004622	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866775004623	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
866775004624	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866775004625	Walker A/P-loop; other site
866775004626	ATP binding site [chemical binding]; other site
866775004627	Q-loop/lid; other site
866775004628	ABC transporter signature motif; other site
866775004629	Walker B; other site
866775004630	D-loop; other site
866775004631	H-loop/switch region; other site
866775004632	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
866775004633	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
866775004634	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
866775004635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775004636	dimer interface [polypeptide binding]; other site
866775004637	conserved gate region; other site
866775004638	putative PBP binding loops; other site
866775004639	ABC-ATPase subunit interface; other site
866775004640	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866775004641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775004642	dimer interface [polypeptide binding]; other site
866775004643	conserved gate region; other site
866775004644	putative PBP binding loops; other site
866775004645	ABC-ATPase subunit interface; other site
866775004646	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866775004647	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775004648	peptide binding site [polypeptide binding]; other site
866775004649	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775004650	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866775004651	peptide binding site [polypeptide binding]; other site
866775004652	dipeptidase PepV; Reviewed; Region: PRK07318
866775004653	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
866775004654	metal binding site [ion binding]; metal-binding site
866775004655	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
866775004656	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
866775004657	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
866775004658	active site
866775004659	S-adenosylmethionine synthetase; Validated; Region: PRK05250
866775004660	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
866775004661	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
866775004662	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
866775004663	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
866775004664	Low molecular weight phosphatase family; Region: LMWPc; cd00115
866775004665	active site
866775004666	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
866775004667	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
866775004668	active site
866775004669	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
866775004670	dimer interface [polypeptide binding]; other site
866775004671	substrate binding site [chemical binding]; other site
866775004672	catalytic residues [active]
866775004673	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
866775004674	Class I aldolases; Region: Aldolase_Class_I; cl17187
866775004675	catalytic residue [active]
866775004676	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
866775004677	TPR repeat; Region: TPR_11; pfam13414
866775004678	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
866775004679	binding surface
866775004680	TPR motif; other site
866775004681	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
866775004682	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
866775004683	gamma-glutamyl kinase; Provisional; Region: PRK05429
866775004684	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
866775004685	nucleotide binding site [chemical binding]; other site
866775004686	homotetrameric interface [polypeptide binding]; other site
866775004687	putative phosphate binding site [ion binding]; other site
866775004688	putative allosteric binding site; other site
866775004689	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
866775004690	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
866775004691	putative catalytic cysteine [active]
866775004692	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
866775004693	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866775004694	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
866775004695	Chain length determinant protein; Region: Wzz; cl15801
866775004696	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
866775004697	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
866775004698	putative active site [active]
866775004699	nucleotide binding site [chemical binding]; other site
866775004700	nudix motif; other site
866775004701	putative metal binding site [ion binding]; other site
866775004702	EDD domain protein, DegV family; Region: DegV; TIGR00762
866775004703	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866775004704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
866775004705	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
866775004706	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
866775004707	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
866775004708	active site
866775004709	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
866775004710	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
866775004711	active site
866775004712	(T/H)XGH motif; other site
866775004713	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
866775004714	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
866775004715	active site
866775004716	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866775004717	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866775004718	DNA-binding site [nucleotide binding]; DNA binding site
866775004719	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866775004720	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
866775004721	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775004722	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
866775004723	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
866775004724	NodB motif; other site
866775004725	active site
866775004726	catalytic site [active]
866775004727	metal binding site [ion binding]; metal-binding site
866775004728	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
866775004729	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
866775004730	Ligand binding site; other site
866775004731	Putative Catalytic site; other site
866775004732	DXD motif; other site
866775004733	Predicted membrane protein [Function unknown]; Region: COG2246
866775004734	GtrA-like protein; Region: GtrA; pfam04138
866775004735	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866775004736	active site
866775004737	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
866775004738	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
866775004739	active site
866775004740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
866775004741	active site
866775004742	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
866775004743	NeuB family; Region: NeuB; pfam03102
866775004744	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
866775004745	NeuB binding interface [polypeptide binding]; other site
866775004746	putative substrate binding site [chemical binding]; other site
866775004747	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
866775004748	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
866775004749	NodB motif; other site
866775004750	active site
866775004751	catalytic site [active]
866775004752	metal binding site [ion binding]; metal-binding site
866775004753	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866775004754	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
866775004755	pur operon repressor; Provisional; Region: PRK09213
866775004756	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
866775004757	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775004758	active site
866775004759	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
866775004760	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
866775004761	putative PBP binding regions; other site
866775004762	ABC-ATPase subunit  interface; other site
866775004763	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775004764	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
866775004765	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
866775004766	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
866775004767	metal binding site [ion binding]; metal-binding site
866775004768	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
866775004769	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
866775004770	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
866775004771	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
866775004772	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
866775004773	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775004774	Walker A/P-loop; other site
866775004775	ATP binding site [chemical binding]; other site
866775004776	Q-loop/lid; other site
866775004777	ABC transporter signature motif; other site
866775004778	Walker B; other site
866775004779	D-loop; other site
866775004780	H-loop/switch region; other site
866775004781	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
866775004782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775004783	S-adenosylmethionine binding site [chemical binding]; other site
866775004784	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
866775004785	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
866775004786	putative active site [active]
866775004787	putative metal binding site [ion binding]; other site
866775004788	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
866775004789	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
866775004790	active site
866775004791	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
866775004792	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
866775004793	active site
866775004794	HIGH motif; other site
866775004795	KMSKS motif; other site
866775004796	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
866775004797	tRNA binding surface [nucleotide binding]; other site
866775004798	anticodon binding site; other site
866775004799	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
866775004800	dimer interface [polypeptide binding]; other site
866775004801	putative tRNA-binding site [nucleotide binding]; other site
866775004802	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
866775004803	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
866775004804	active site
866775004805	HIGH motif; other site
866775004806	dimer interface [polypeptide binding]; other site
866775004807	KMSKS motif; other site
866775004808	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
866775004809	RNA binding surface [nucleotide binding]; other site
866775004810	T-box leader
866775004811	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
866775004812	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
866775004813	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866775004814	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
866775004815	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866775004816	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
866775004817	ykoK leader
866775004818	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
866775004819	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
866775004820	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
866775004821	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
866775004822	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
866775004823	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
866775004824	Protein of unknown function (DUF3579); Region: DUF3579; pfam12112
866775004825	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
866775004826	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
866775004827	hypothetical protein; Validated; Region: PRK07682
866775004828	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866775004829	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775004830	homodimer interface [polypeptide binding]; other site
866775004831	catalytic residue [active]
866775004832	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
866775004833	AsnC family; Region: AsnC_trans_reg; pfam01037
866775004834	Predicted secreted protein [Function unknown]; Region: COG4086
866775004835	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
866775004836	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
866775004837	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
866775004838	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
866775004839	protein binding site [polypeptide binding]; other site
866775004840	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
866775004841	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
866775004842	YycH protein; Region: YycI; pfam09648
866775004843	YycH protein; Region: YycH; pfam07435
866775004844	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
866775004845	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
866775004846	dimerization interface [polypeptide binding]; other site
866775004847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
866775004848	putative active site [active]
866775004849	heme pocket [chemical binding]; other site
866775004850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866775004851	dimer interface [polypeptide binding]; other site
866775004852	phosphorylation site [posttranslational modification]
866775004853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775004854	ATP binding site [chemical binding]; other site
866775004855	Mg2+ binding site [ion binding]; other site
866775004856	G-X-G motif; other site
866775004857	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775004858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775004859	active site
866775004860	phosphorylation site [posttranslational modification]
866775004861	intermolecular recognition site; other site
866775004862	dimerization interface [polypeptide binding]; other site
866775004863	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775004864	DNA binding site [nucleotide binding]
866775004865	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004866	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775004867	CHAP domain; Region: CHAP; pfam05257
866775004868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
866775004869	Biotin operon repressor [Transcription]; Region: BirA; COG1654
866775004870	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
866775004871	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
866775004872	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
866775004873	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866775004874	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
866775004875	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
866775004876	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
866775004877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775004878	S-adenosylmethionine binding site [chemical binding]; other site
866775004879	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
866775004880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
866775004881	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866775004882	active site
866775004883	motif I; other site
866775004884	motif II; other site
866775004885	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775004886	Uncharacterized conserved protein [Function unknown]; Region: COG2966
866775004887	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
866775004888	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
866775004889	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866775004890	Tannase and feruloyl esterase; Region: Tannase; pfam07519
866775004891	TAP-like protein; Region: Abhydrolase_4; pfam08386
866775004892	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
866775004893	active site
866775004894	multifunctional aminopeptidase A; Provisional; Region: PRK00913
866775004895	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
866775004896	interface (dimer of trimers) [polypeptide binding]; other site
866775004897	Substrate-binding/catalytic site; other site
866775004898	Zn-binding sites [ion binding]; other site
866775004899	S-formylglutathione hydrolase; Region: PLN02442
866775004900	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
866775004901	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866775004902	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
866775004903	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
866775004904	active site
866775004905	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
866775004906	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
866775004907	domain interfaces; other site
866775004908	active site
866775004909	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
866775004910	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
866775004911	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
866775004912	cobyric acid synthase; Provisional; Region: PRK00784
866775004913	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
866775004914	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
866775004915	conserved cys residue [active]
866775004916	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
866775004917	active site
866775004918	SAM binding site [chemical binding]; other site
866775004919	homodimer interface [polypeptide binding]; other site
866775004920	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
866775004921	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
866775004922	active site
866775004923	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
866775004924	active site
866775004925	N-terminal domain interface [polypeptide binding]; other site
866775004926	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
866775004927	active site
866775004928	SAM binding site [chemical binding]; other site
866775004929	homodimer interface [polypeptide binding]; other site
866775004930	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
866775004931	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
866775004932	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
866775004933	active site
866775004934	SAM binding site [chemical binding]; other site
866775004935	homodimer interface [polypeptide binding]; other site
866775004936	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
866775004937	active site
866775004938	SAM binding site [chemical binding]; other site
866775004939	homodimer interface [polypeptide binding]; other site
866775004940	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
866775004941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775004942	S-adenosylmethionine binding site [chemical binding]; other site
866775004943	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
866775004944	active site
866775004945	putative homodimer interface [polypeptide binding]; other site
866775004946	SAM binding site [chemical binding]; other site
866775004947	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
866775004948	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
866775004949	Precorrin-8X methylmutase; Region: CbiC; pfam02570
866775004950	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
866775004951	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
866775004952	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
866775004953	catalytic triad [active]
866775004954	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
866775004955	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775004956	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866775004957	peptide binding site [polypeptide binding]; other site
866775004958	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
866775004959	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
866775004960	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
866775004961	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775004962	homodimer interface [polypeptide binding]; other site
866775004963	catalytic residue [active]
866775004964	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
866775004965	catalytic core [active]
866775004966	cobalamin synthase; Reviewed; Region: cobS; PRK00235
866775004967	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
866775004968	homotrimer interface [polypeptide binding]; other site
866775004969	Walker A motif; other site
866775004970	GTP binding site [chemical binding]; other site
866775004971	Walker B motif; other site
866775004972	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
866775004973	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
866775004974	THF binding site; other site
866775004975	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
866775004976	substrate binding site [chemical binding]; other site
866775004977	THF binding site; other site
866775004978	zinc-binding site [ion binding]; other site
866775004979	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
866775004980	FAD binding site [chemical binding]; other site
866775004981	carbamate kinase; Reviewed; Region: PRK12686
866775004982	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
866775004983	putative substrate binding site [chemical binding]; other site
866775004984	nucleotide binding site [chemical binding]; other site
866775004985	nucleotide binding site [chemical binding]; other site
866775004986	homodimer interface [polypeptide binding]; other site
866775004987	Uncharacterized conserved protein [Function unknown]; Region: COG1915
866775004988	TIGR00300 family protein; Region: TIGR00300
866775004989	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528
866775004990	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
866775004991	Clp amino terminal domain; Region: Clp_N; pfam02861
866775004992	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004993	Walker A motif; other site
866775004994	ATP binding site [chemical binding]; other site
866775004995	Walker B motif; other site
866775004996	arginine finger; other site
866775004997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
866775004998	Walker A motif; other site
866775004999	ATP binding site [chemical binding]; other site
866775005000	Walker B motif; other site
866775005001	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
866775005002	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
866775005003	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
866775005004	ornithine carbamoyltransferase; Validated; Region: PRK02102
866775005005	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
866775005006	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
866775005007	Helix-turn-helix domain; Region: HTH_18; pfam12833
866775005008	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
866775005009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
866775005010	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
866775005011	EamA-like transporter family; Region: EamA; pfam00892
866775005012	EamA-like transporter family; Region: EamA; pfam00892
866775005013	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
866775005014	AIR carboxylase; Region: AIRC; smart01001
866775005015	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
866775005016	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
866775005017	Ligand Binding Site [chemical binding]; other site
866775005018	Helix-turn-helix domain; Region: HTH_18; pfam12833
866775005019	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
866775005020	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
866775005021	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
866775005022	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
866775005023	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
866775005024	putative dimer interface [polypeptide binding]; other site
866775005025	N-terminal domain interface [polypeptide binding]; other site
866775005026	putative substrate binding pocket (H-site) [chemical binding]; other site
866775005027	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
866775005028	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775005029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775005030	active site
866775005031	phosphorylation site [posttranslational modification]
866775005032	intermolecular recognition site; other site
866775005033	dimerization interface [polypeptide binding]; other site
866775005034	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775005035	DNA binding site [nucleotide binding]
866775005036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866775005037	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866775005038	dimer interface [polypeptide binding]; other site
866775005039	phosphorylation site [posttranslational modification]
866775005040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775005041	ATP binding site [chemical binding]; other site
866775005042	Mg2+ binding site [ion binding]; other site
866775005043	G-X-G motif; other site
866775005044	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
866775005045	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866775005046	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866775005047	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775005048	Walker A/P-loop; other site
866775005049	ATP binding site [chemical binding]; other site
866775005050	Q-loop/lid; other site
866775005051	ABC transporter signature motif; other site
866775005052	Walker B; other site
866775005053	D-loop; other site
866775005054	H-loop/switch region; other site
866775005055	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
866775005056	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
866775005057	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
866775005058	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
866775005059	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
866775005060	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
866775005061	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
866775005062	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
866775005063	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
866775005064	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
866775005065	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
866775005066	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
866775005067	metal binding site [ion binding]; metal-binding site
866775005068	beta-D-glucuronidase; Provisional; Region: PRK10150
866775005069	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
866775005070	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
866775005071	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
866775005072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
866775005073	hypothetical protein; Provisional; Region: PRK13663
866775005074	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
866775005075	TrkA-N domain; Region: TrkA_N; pfam02254
866775005076	TrkA-C domain; Region: TrkA_C; pfam02080
866775005077	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
866775005078	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
866775005079	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
866775005080	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
866775005081	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
866775005082	Walker A/P-loop; other site
866775005083	ATP binding site [chemical binding]; other site
866775005084	Q-loop/lid; other site
866775005085	ABC transporter signature motif; other site
866775005086	Walker B; other site
866775005087	D-loop; other site
866775005088	H-loop/switch region; other site
866775005089	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
866775005090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005091	dimer interface [polypeptide binding]; other site
866775005092	conserved gate region; other site
866775005093	putative PBP binding loops; other site
866775005094	ABC-ATPase subunit interface; other site
866775005095	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
866775005096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005097	dimer interface [polypeptide binding]; other site
866775005098	conserved gate region; other site
866775005099	putative PBP binding loops; other site
866775005100	ABC-ATPase subunit interface; other site
866775005101	PBP superfamily domain; Region: PBP_like_2; cl17296
866775005102	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
866775005103	HAMP domain; Region: HAMP; pfam00672
866775005104	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
866775005105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
866775005106	dimer interface [polypeptide binding]; other site
866775005107	phosphorylation site [posttranslational modification]
866775005108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775005109	ATP binding site [chemical binding]; other site
866775005110	Mg2+ binding site [ion binding]; other site
866775005111	G-X-G motif; other site
866775005112	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775005113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775005114	active site
866775005115	phosphorylation site [posttranslational modification]
866775005116	intermolecular recognition site; other site
866775005117	dimerization interface [polypeptide binding]; other site
866775005118	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775005119	DNA binding site [nucleotide binding]
866775005120	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
866775005121	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
866775005122	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775005123	nucleotide binding region [chemical binding]; other site
866775005124	ATP-binding site [chemical binding]; other site
866775005125	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
866775005126	30S subunit binding site; other site
866775005127	comF family protein; Region: comF; TIGR00201
866775005128	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
866775005129	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
866775005130	active site
866775005131	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
866775005132	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
866775005133	ATP binding site [chemical binding]; other site
866775005134	putative Mg++ binding site [ion binding]; other site
866775005135	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
866775005136	nucleotide binding region [chemical binding]; other site
866775005137	ATP-binding site [chemical binding]; other site
866775005138	Uncharacterized conserved protein [Function unknown]; Region: COG1739
866775005139	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
866775005140	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
866775005141	putative transposase OrfB; Reviewed; Region: PHA02517
866775005142	HTH-like domain; Region: HTH_21; pfam13276
866775005143	Integrase core domain; Region: rve; pfam00665
866775005144	Integrase core domain; Region: rve_2; pfam13333
866775005145	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
866775005146	active site
866775005147	intersubunit interface [polypeptide binding]; other site
866775005148	catalytic residue [active]
866775005149	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
866775005150	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
866775005151	Substrate-binding site [chemical binding]; other site
866775005152	Substrate specificity [chemical binding]; other site
866775005153	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
866775005154	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
866775005155	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
866775005156	prolyl-tRNA synthetase; Provisional; Region: PRK08661
866775005157	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
866775005158	dimer interface [polypeptide binding]; other site
866775005159	motif 1; other site
866775005160	active site
866775005161	motif 2; other site
866775005162	motif 3; other site
866775005163	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
866775005164	anticodon binding site; other site
866775005165	T-box leader
866775005166	catabolite control protein A; Region: ccpA; TIGR01481
866775005167	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866775005168	DNA binding site [nucleotide binding]
866775005169	domain linker motif; other site
866775005170	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866775005171	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
866775005172	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
866775005173	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
866775005174	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
866775005175	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
866775005176	active site
866775005177	phosphorylation site [posttranslational modification]
866775005178	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
866775005179	HTH domain; Region: HTH_11; pfam08279
866775005180	PRD domain; Region: PRD; pfam00874
866775005181	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
866775005182	active site
866775005183	P-loop; other site
866775005184	phosphorylation site [posttranslational modification]
866775005185	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
866775005186	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
866775005187	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
866775005188	active site
866775005189	P-loop; other site
866775005190	phosphorylation site [posttranslational modification]
866775005191	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
866775005192	active site
866775005193	P-loop; other site
866775005194	phosphorylation site [posttranslational modification]
866775005195	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
866775005196	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
866775005197	active site
866775005198	trimer interface [polypeptide binding]; other site
866775005199	allosteric site; other site
866775005200	active site lid [active]
866775005201	hexamer (dimer of trimers) interface [polypeptide binding]; other site
866775005202	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
866775005203	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
866775005204	NAD binding site [chemical binding]; other site
866775005205	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775005206	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775005207	substrate binding pocket [chemical binding]; other site
866775005208	membrane-bound complex binding site; other site
866775005209	hinge residues; other site
866775005210	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866775005211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005212	dimer interface [polypeptide binding]; other site
866775005213	conserved gate region; other site
866775005214	putative PBP binding loops; other site
866775005215	ABC-ATPase subunit interface; other site
866775005216	argininosuccinate lyase; Provisional; Region: PRK00855
866775005217	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
866775005218	active sites [active]
866775005219	tetramer interface [polypeptide binding]; other site
866775005220	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
866775005221	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
866775005222	substrate binding pocket [chemical binding]; other site
866775005223	membrane-bound complex binding site; other site
866775005224	hinge residues; other site
866775005225	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
866775005226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005227	dimer interface [polypeptide binding]; other site
866775005228	conserved gate region; other site
866775005229	putative PBP binding loops; other site
866775005230	ABC-ATPase subunit interface; other site
866775005231	T-box leader
866775005232	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
866775005233	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
866775005234	NAD binding site [chemical binding]; other site
866775005235	catalytic residues [active]
866775005236	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
866775005237	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
866775005238	hypothetical protein; Provisional; Region: PRK11588
866775005239	isoaspartyl dipeptidase; Provisional; Region: PRK10657
866775005240	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
866775005241	active site
866775005242	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
866775005243	adenylosuccinate lyase; Provisional; Region: PRK07492
866775005244	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
866775005245	tetramer interface [polypeptide binding]; other site
866775005246	active site
866775005247	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
866775005248	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
866775005249	GDP-binding site [chemical binding]; other site
866775005250	ACT binding site; other site
866775005251	IMP binding site; other site
866775005252	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
866775005253	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
866775005254	ring oligomerisation interface [polypeptide binding]; other site
866775005255	ATP/Mg binding site [chemical binding]; other site
866775005256	stacking interactions; other site
866775005257	hinge regions; other site
866775005258	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
866775005259	oligomerisation interface [polypeptide binding]; other site
866775005260	mobile loop; other site
866775005261	roof hairpin; other site
866775005262	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
866775005263	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
866775005264	CoA binding domain; Region: CoA_binding; pfam02629
866775005265	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
866775005266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775005267	Walker A/P-loop; other site
866775005268	ATP binding site [chemical binding]; other site
866775005269	Q-loop/lid; other site
866775005270	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775005271	ABC transporter signature motif; other site
866775005272	Walker B; other site
866775005273	D-loop; other site
866775005274	ABC transporter; Region: ABC_tran_2; pfam12848
866775005275	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775005276	Protein of unknown function (DUF503); Region: DUF503; cl00669
866775005277	UGMP family protein; Validated; Region: PRK09604
866775005278	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
866775005279	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775005280	Coenzyme A binding pocket [chemical binding]; other site
866775005281	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
866775005282	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775005283	Coenzyme A binding pocket [chemical binding]; other site
866775005284	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
866775005285	Glycoprotease family; Region: Peptidase_M22; pfam00814
866775005286	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
866775005287	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
866775005288	Transposase; Region: DDE_Tnp_ISL3; pfam01610
866775005289	Condensation domain; Region: Condensation; pfam00668
866775005290	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
866775005291	active site
866775005292	putative catalytic site [active]
866775005293	DNA binding site [nucleotide binding]
866775005294	putative phosphate binding site [ion binding]; other site
866775005295	metal binding site A [ion binding]; metal-binding site
866775005296	AP binding site [nucleotide binding]; other site
866775005297	metal binding site B [ion binding]; metal-binding site
866775005298	SWIM zinc finger; Region: SWIM; pfam04434
866775005299	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775005300	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005301	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005302	Homeodomain-like domain; Region: HTH_32; pfam13565
866775005303	putative transposase OrfB; Reviewed; Region: PHA02517
866775005304	HTH-like domain; Region: HTH_21; pfam13276
866775005305	Integrase core domain; Region: rve; pfam00665
866775005306	Integrase core domain; Region: rve_2; pfam13333
866775005307	D-lactate dehydrogenase; Validated; Region: PRK08605
866775005308	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
866775005309	homodimer interface [polypeptide binding]; other site
866775005310	ligand binding site [chemical binding]; other site
866775005311	NAD binding site [chemical binding]; other site
866775005312	catalytic site [active]
866775005313	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
866775005314	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
866775005315	N-terminal domain interface [polypeptide binding]; other site
866775005316	dimer interface [polypeptide binding]; other site
866775005317	substrate binding pocket (H-site) [chemical binding]; other site
866775005318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
866775005319	RelB antitoxin; Region: RelB; cl01171
866775005320	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
866775005321	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
866775005322	nudix motif; other site
866775005323	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
866775005324	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
866775005325	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
866775005326	NAD binding site [chemical binding]; other site
866775005327	substrate binding site [chemical binding]; other site
866775005328	active site
866775005329	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866775005330	active site residue [active]
866775005331	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
866775005332	active site residue [active]
866775005333	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
866775005334	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866775005335	Protein of unknown function (DUF554); Region: DUF554; pfam04474
866775005336	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
866775005337	Pleckstrin homology-like domain; Region: PH-like; cl17171
866775005338	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
866775005339	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
866775005340	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
866775005341	G5 domain; Region: G5; pfam07501
866775005342	G5 domain; Region: G5; pfam07501
866775005343	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775005344	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866775005345	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775005346	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
866775005347	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
866775005348	active site
866775005349	metal binding site [ion binding]; metal-binding site
866775005350	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
866775005351	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
866775005352	active site residue [active]
866775005353	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
866775005354	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
866775005355	substrate binding site [chemical binding]; other site
866775005356	THF binding site; other site
866775005357	zinc-binding site [ion binding]; other site
866775005358	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
866775005359	FMN binding site [chemical binding]; other site
866775005360	dimer interface [polypeptide binding]; other site
866775005361	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
866775005362	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
866775005363	intersubunit interface [polypeptide binding]; other site
866775005364	active site
866775005365	zinc binding site [ion binding]; other site
866775005366	Na+ binding site [ion binding]; other site
866775005367	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
866775005368	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
866775005369	teramer interface [polypeptide binding]; other site
866775005370	active site
866775005371	FMN binding site [chemical binding]; other site
866775005372	catalytic residues [active]
866775005373	FtsX-like permease family; Region: FtsX; pfam02687
866775005374	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775005375	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775005376	Walker A/P-loop; other site
866775005377	ATP binding site [chemical binding]; other site
866775005378	Q-loop/lid; other site
866775005379	ABC transporter signature motif; other site
866775005380	Walker B; other site
866775005381	D-loop; other site
866775005382	H-loop/switch region; other site
866775005383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866775005384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775005385	ATP binding site [chemical binding]; other site
866775005386	Mg2+ binding site [ion binding]; other site
866775005387	G-X-G motif; other site
866775005388	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775005389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775005390	active site
866775005391	phosphorylation site [posttranslational modification]
866775005392	intermolecular recognition site; other site
866775005393	dimerization interface [polypeptide binding]; other site
866775005394	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775005395	DNA binding site [nucleotide binding]
866775005396	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
866775005397	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
866775005398	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
866775005399	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
866775005400	DNA binding residues [nucleotide binding]
866775005401	dimer interface [polypeptide binding]; other site
866775005402	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
866775005403	T-box leader
866775005404	T-box leader
866775005405	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
866775005406	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
866775005407	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
866775005408	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
866775005409	active site
866775005410	ribulose/triose binding site [chemical binding]; other site
866775005411	phosphate binding site [ion binding]; other site
866775005412	substrate (anthranilate) binding pocket [chemical binding]; other site
866775005413	product (indole) binding pocket [chemical binding]; other site
866775005414	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
866775005415	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
866775005416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
866775005417	catalytic residue [active]
866775005418	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
866775005419	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
866775005420	substrate binding site [chemical binding]; other site
866775005421	active site
866775005422	catalytic residues [active]
866775005423	heterodimer interface [polypeptide binding]; other site
866775005424	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
866775005425	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
866775005426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
866775005427	esterase; Provisional; Region: PRK10566
866775005428	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
866775005429	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
866775005430	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
866775005431	DNA binding site [nucleotide binding]
866775005432	active site
866775005433	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
866775005434	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
866775005435	AAA domain; Region: AAA_12; pfam13087
866775005436	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
866775005437	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
866775005438	intersubunit interface [polypeptide binding]; other site
866775005439	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
866775005440	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
866775005441	ABC-ATPase subunit  interface; other site
866775005442	dimer interface [polypeptide binding]; other site
866775005443	putative PBP binding regions; other site
866775005444	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
866775005445	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
866775005446	Walker A/P-loop; other site
866775005447	ATP binding site [chemical binding]; other site
866775005448	Q-loop/lid; other site
866775005449	ABC transporter signature motif; other site
866775005450	Walker B; other site
866775005451	D-loop; other site
866775005452	H-loop/switch region; other site
866775005453	PAS domain; Region: PAS_10; pfam13596
866775005454	PAS domain; Region: PAS_10; pfam13596
866775005455	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
866775005456	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866775005457	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866775005458	active site
866775005459	catalytic tetrad [active]
866775005460	TIGR04076 family protein; Region: TIGR04076
866775005461	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866775005462	FtsX-like permease family; Region: FtsX; pfam02687
866775005463	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775005464	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775005465	Walker A/P-loop; other site
866775005466	ATP binding site [chemical binding]; other site
866775005467	Q-loop/lid; other site
866775005468	ABC transporter signature motif; other site
866775005469	Walker B; other site
866775005470	D-loop; other site
866775005471	H-loop/switch region; other site
866775005472	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
866775005473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
866775005474	dimer interface [polypeptide binding]; other site
866775005475	phosphorylation site [posttranslational modification]
866775005476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775005477	ATP binding site [chemical binding]; other site
866775005478	Mg2+ binding site [ion binding]; other site
866775005479	G-X-G motif; other site
866775005480	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
866775005481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775005482	active site
866775005483	phosphorylation site [posttranslational modification]
866775005484	intermolecular recognition site; other site
866775005485	dimerization interface [polypeptide binding]; other site
866775005486	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
866775005487	DNA binding site [nucleotide binding]
866775005488	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866775005489	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775005490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866775005491	putative substrate translocation pore; other site
866775005492	FtsX-like permease family; Region: FtsX; pfam02687
866775005493	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775005494	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775005495	Walker A/P-loop; other site
866775005496	ATP binding site [chemical binding]; other site
866775005497	Q-loop/lid; other site
866775005498	ABC transporter signature motif; other site
866775005499	Walker B; other site
866775005500	D-loop; other site
866775005501	H-loop/switch region; other site
866775005502	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
866775005503	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
866775005504	Transcriptional regulator PadR-like family; Region: PadR; cl17335
866775005505	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775005506	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005507	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005508	Homeodomain-like domain; Region: HTH_32; pfam13565
866775005509	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
866775005510	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866775005511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
866775005512	Walker A/P-loop; other site
866775005513	ATP binding site [chemical binding]; other site
866775005514	Q-loop/lid; other site
866775005515	ABC transporter signature motif; other site
866775005516	Walker B; other site
866775005517	D-loop; other site
866775005518	H-loop/switch region; other site
866775005519	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
866775005520	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
866775005521	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
866775005522	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775005523	S-adenosylmethionine binding site [chemical binding]; other site
866775005524	Isochorismatase family; Region: Isochorismatase; pfam00857
866775005525	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
866775005526	catalytic triad [active]
866775005527	conserved cis-peptide bond; other site
866775005528	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
866775005529	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
866775005530	Coenzyme A binding pocket [chemical binding]; other site
866775005531	hypothetical protein; Provisional; Region: PRK07758
866775005532	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866775005533	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775005534	ABC transporter; Region: ABC_tran_2; pfam12848
866775005535	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
866775005536	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
866775005537	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774
866775005538	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
866775005539	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866775005540	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866775005541	Walker A/P-loop; other site
866775005542	ATP binding site [chemical binding]; other site
866775005543	Q-loop/lid; other site
866775005544	ABC transporter signature motif; other site
866775005545	Walker B; other site
866775005546	D-loop; other site
866775005547	H-loop/switch region; other site
866775005548	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
866775005549	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866775005550	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866775005551	Walker A/P-loop; other site
866775005552	ATP binding site [chemical binding]; other site
866775005553	Q-loop/lid; other site
866775005554	ABC transporter signature motif; other site
866775005555	Walker B; other site
866775005556	D-loop; other site
866775005557	H-loop/switch region; other site
866775005558	hypothetical protein; Provisional; Region: PRK13661
866775005559	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
866775005560	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
866775005561	DNA binding residues [nucleotide binding]
866775005562	dimer interface [polypeptide binding]; other site
866775005563	TRAM domain; Region: TRAM; cl01282
866775005564	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
866775005565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
866775005566	S-adenosylmethionine binding site [chemical binding]; other site
866775005567	esterase; Provisional; Region: PRK10566
866775005568	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
866775005569	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
866775005570	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
866775005571	active site
866775005572	catalytic tetrad [active]
866775005573	S-ribosylhomocysteinase; Provisional; Region: PRK02260
866775005574	Transcriptional regulators [Transcription]; Region: PurR; COG1609
866775005575	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
866775005576	DNA binding site [nucleotide binding]
866775005577	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
866775005578	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
866775005579	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
866775005580	active site
866775005581	metal binding site [ion binding]; metal-binding site
866775005582	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
866775005583	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
866775005584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005585	dimer interface [polypeptide binding]; other site
866775005586	conserved gate region; other site
866775005587	putative PBP binding loops; other site
866775005588	ABC-ATPase subunit interface; other site
866775005589	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
866775005590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005591	dimer interface [polypeptide binding]; other site
866775005592	conserved gate region; other site
866775005593	ABC-ATPase subunit interface; other site
866775005594	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
866775005595	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
866775005596	Walker A/P-loop; other site
866775005597	ATP binding site [chemical binding]; other site
866775005598	Q-loop/lid; other site
866775005599	ABC transporter signature motif; other site
866775005600	Walker B; other site
866775005601	D-loop; other site
866775005602	H-loop/switch region; other site
866775005603	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
866775005604	High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646
866775005605	G5 domain; Region: G5; pfam07501
866775005606	G5 domain; Region: G5; pfam07501
866775005607	G5 domain; Region: G5; pfam07501
866775005608	G5 domain; Region: G5; pfam07501
866775005609	G5 domain; Region: G5; pfam07501
866775005610	G5 domain; Region: G5; pfam07501
866775005611	G5 domain; Region: G5; pfam07501
866775005612	G5 domain; Region: G5; pfam07501
866775005613	G5 domain; Region: G5; pfam07501
866775005614	G5 domain; Region: G5; pfam07501
866775005615	G5 domain; Region: G5; pfam07501
866775005616	G5 domain; Region: G5; pfam07501
866775005617	G5 domain; Region: G5; pfam07501
866775005618	G5 domain; Region: G5; pfam07501
866775005619	Herpesvirus ICP4-like protein N-terminal region; Region: Herpes_ICP4_N; cl17480
866775005620	putative transposase OrfB; Reviewed; Region: PHA02517
866775005621	HTH-like domain; Region: HTH_21; pfam13276
866775005622	Integrase core domain; Region: rve; pfam00665
866775005623	Integrase core domain; Region: rve_2; pfam13333
866775005624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775005625	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005626	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005627	Homeodomain-like domain; Region: HTH_32; pfam13565
866775005628	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
866775005629	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
866775005630	GatB domain; Region: GatB_Yqey; pfam02637
866775005631	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
866775005632	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
866775005633	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
866775005634	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
866775005635	putative dimer interface [polypeptide binding]; other site
866775005636	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
866775005637	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
866775005638	putative dimer interface [polypeptide binding]; other site
866775005639	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
866775005640	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
866775005641	nucleotide binding pocket [chemical binding]; other site
866775005642	K-X-D-G motif; other site
866775005643	catalytic site [active]
866775005644	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
866775005645	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
866775005646	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
866775005647	Dimer interface [polypeptide binding]; other site
866775005648	BRCT sequence motif; other site
866775005649	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
866775005650	Part of AAA domain; Region: AAA_19; pfam13245
866775005651	Family description; Region: UvrD_C_2; pfam13538
866775005652	Transcriptional regulators [Transcription]; Region: GntR; COG1802
866775005653	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
866775005654	DNA-binding site [nucleotide binding]; DNA binding site
866775005655	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
866775005656	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
866775005657	HTH domain; Region: HTH_11; pfam08279
866775005658	FOG: CBS domain [General function prediction only]; Region: COG0517
866775005659	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
866775005660	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
866775005661	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
866775005662	Walker A/P-loop; other site
866775005663	ATP binding site [chemical binding]; other site
866775005664	Q-loop/lid; other site
866775005665	ABC transporter signature motif; other site
866775005666	Walker B; other site
866775005667	D-loop; other site
866775005668	H-loop/switch region; other site
866775005669	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
866775005670	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
866775005671	Walker A/P-loop; other site
866775005672	ATP binding site [chemical binding]; other site
866775005673	Q-loop/lid; other site
866775005674	ABC transporter signature motif; other site
866775005675	Walker B; other site
866775005676	D-loop; other site
866775005677	H-loop/switch region; other site
866775005678	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
866775005679	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
866775005680	TM-ABC transporter signature motif; other site
866775005681	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
866775005682	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
866775005683	TM-ABC transporter signature motif; other site
866775005684	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866775005685	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
866775005686	putative ligand binding site [chemical binding]; other site
866775005687	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866775005688	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
866775005689	putative ligand binding site [chemical binding]; other site
866775005690	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
866775005691	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
866775005692	putative ligand binding site [chemical binding]; other site
866775005693	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866775005694	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
866775005695	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
866775005696	dimer interface [polypeptide binding]; other site
866775005697	ligand binding site [chemical binding]; other site
866775005698	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866775005699	FtsX-like permease family; Region: FtsX; pfam02687
866775005700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
866775005701	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
866775005702	FtsX-like permease family; Region: FtsX; pfam02687
866775005703	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
866775005704	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
866775005705	Walker A/P-loop; other site
866775005706	ATP binding site [chemical binding]; other site
866775005707	Q-loop/lid; other site
866775005708	ABC transporter signature motif; other site
866775005709	Walker B; other site
866775005710	D-loop; other site
866775005711	H-loop/switch region; other site
866775005712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
866775005713	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
866775005714	active site
866775005715	motif I; other site
866775005716	motif II; other site
866775005717	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
866775005718	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
866775005719	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
866775005720	putative active site [active]
866775005721	DNA repair protein RadA; Provisional; Region: PRK11823
866775005722	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
866775005723	Walker A motif/ATP binding site; other site
866775005724	ATP binding site [chemical binding]; other site
866775005725	Walker B motif; other site
866775005726	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
866775005727	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
866775005728	trimer interface [polypeptide binding]; other site
866775005729	active site
866775005730	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
866775005731	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775005732	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005733	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005734	Homeodomain-like domain; Region: HTH_32; pfam13565
866775005735	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866775005736	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775005737	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
866775005738	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
866775005739	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
866775005740	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
866775005741	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
866775005742	GTP-binding protein YchF; Reviewed; Region: PRK09601
866775005743	YchF GTPase; Region: YchF; cd01900
866775005744	G1 box; other site
866775005745	GTP/Mg2+ binding site [chemical binding]; other site
866775005746	Switch I region; other site
866775005747	G2 box; other site
866775005748	Switch II region; other site
866775005749	G3 box; other site
866775005750	G4 box; other site
866775005751	G5 box; other site
866775005752	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
866775005753	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
866775005754	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
866775005755	ParB-like nuclease domain; Region: ParBc; pfam02195
866775005756	KorB domain; Region: KorB; pfam08535
866775005757	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
866775005758	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
866775005759	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
866775005760	Magnesium ion binding site [ion binding]; other site
866775005761	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866775005762	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
866775005763	Walker A/P-loop; other site
866775005764	ATP binding site [chemical binding]; other site
866775005765	Q-loop/lid; other site
866775005766	ABC transporter signature motif; other site
866775005767	Walker B; other site
866775005768	D-loop; other site
866775005769	H-loop/switch region; other site
866775005770	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
866775005771	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
866775005772	FemAB family; Region: FemAB; pfam02388
866775005773	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
866775005774	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866775005775	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
866775005776	lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733
866775005777	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
866775005778	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
866775005779	Walker A/P-loop; other site
866775005780	ATP binding site [chemical binding]; other site
866775005781	Q-loop/lid; other site
866775005782	ABC transporter signature motif; other site
866775005783	Walker B; other site
866775005784	D-loop; other site
866775005785	H-loop/switch region; other site
866775005786	peptidase T; Region: peptidase-T; TIGR01882
866775005787	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
866775005788	metal binding site [ion binding]; metal-binding site
866775005789	dimer interface [polypeptide binding]; other site
866775005790	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
866775005791	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
866775005792	peptide binding site [polypeptide binding]; other site
866775005793	Cna protein B-type domain; Region: Cna_B; pfam05738
866775005794	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
866775005795	domain interaction interfaces [polypeptide binding]; other site
866775005796	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
866775005797	domain interaction interfaces [polypeptide binding]; other site
866775005798	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
866775005799	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
866775005800	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
866775005801	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
866775005802	GAF domain; Region: GAF_3; pfam13492
866775005803	Histidine kinase; Region: His_kinase; pfam06580
866775005804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
866775005805	ATP binding site [chemical binding]; other site
866775005806	Mg2+ binding site [ion binding]; other site
866775005807	G-X-G motif; other site
866775005808	two-component response regulator; Provisional; Region: PRK14084
866775005809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
866775005810	active site
866775005811	phosphorylation site [posttranslational modification]
866775005812	intermolecular recognition site; other site
866775005813	dimerization interface [polypeptide binding]; other site
866775005814	LytTr DNA-binding domain; Region: LytTR; smart00850
866775005815	LrgA family; Region: LrgA; cl00608
866775005816	LrgB-like family; Region: LrgB; cl00596
866775005817	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
866775005818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
866775005819	putative substrate translocation pore; other site
866775005820	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
866775005821	PspC domain; Region: PspC; pfam04024
866775005822	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
866775005823	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
866775005824	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
866775005825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866775005826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
866775005827	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
866775005828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
866775005829	dimer interface [polypeptide binding]; other site
866775005830	conserved gate region; other site
866775005831	putative PBP binding loops; other site
866775005832	ABC-ATPase subunit interface; other site
866775005833	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
866775005834	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866775005835	Walker A/P-loop; other site
866775005836	ATP binding site [chemical binding]; other site
866775005837	Q-loop/lid; other site
866775005838	ABC transporter signature motif; other site
866775005839	Walker B; other site
866775005840	D-loop; other site
866775005841	H-loop/switch region; other site
866775005842	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
866775005843	Walker A/P-loop; other site
866775005844	ATP binding site [chemical binding]; other site
866775005845	Q-loop/lid; other site
866775005846	ABC transporter signature motif; other site
866775005847	Walker B; other site
866775005848	D-loop; other site
866775005849	H-loop/switch region; other site
866775005850	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
866775005851	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005852	Helix-turn-helix domain; Region: HTH_28; pfam13518
866775005853	Homeodomain-like domain; Region: HTH_32; pfam13565
866775005854	putative transposase OrfB; Reviewed; Region: PHA02517
866775005855	HTH-like domain; Region: HTH_21; pfam13276
866775005856	Integrase core domain; Region: rve; pfam00665
866775005857	Integrase core domain; Region: rve_2; pfam13333
866775005858	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
866775005859	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
866775005860	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
866775005861	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
866775005862	non-specific DNA binding site [nucleotide binding]; other site
866775005863	salt bridge; other site
866775005864	sequence-specific DNA binding site [nucleotide binding]; other site
866775005865	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
866775005866	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
866775005867	trmE is a tRNA modification GTPase; Region: trmE; cd04164
866775005868	G1 box; other site
866775005869	GTP/Mg2+ binding site [chemical binding]; other site
866775005870	Switch I region; other site
866775005871	G2 box; other site
866775005872	Switch II region; other site
866775005873	G3 box; other site
866775005874	G4 box; other site
866775005875	G5 box; other site
866775005876	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
866775005877	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
866775005878	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
866775005879	Walker A/P-loop; other site
866775005880	ATP binding site [chemical binding]; other site
866775005881	Q-loop/lid; other site
866775005882	ABC transporter signature motif; other site
866775005883	Walker B; other site
866775005884	D-loop; other site
866775005885	H-loop/switch region; other site
866775005886	Cobalt transport protein; Region: CbiQ; cl00463
866775005887	cobalt transport protein CbiN; Provisional; Region: PRK02898
866775005888	cobalt transport protein CbiM; Validated; Region: PRK08319
866775005889	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
866775005890	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
866775005891	Domain of unknown function DUF21; Region: DUF21; pfam01595
866775005892	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
866775005893	Transporter associated domain; Region: CorC_HlyC; smart01091
866775005894	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
866775005895	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
866775005896	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
866775005897	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
866775005898	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
866775005899	Soluble P-type ATPase [General function prediction only]; Region: COG4087
866775005900	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
866775005901	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
866775005902	Predicted membrane protein [Function unknown]; Region: COG3212
866775005903	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
866775005904	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
866775005905	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
866775005906	active site
866775005907	phosphorylation site [posttranslational modification]
866775005908	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
866775005909	active pocket/dimerization site; other site
866775005910	active site
866775005911	phosphorylation site [posttranslational modification]
866775005912	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
866775005913	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
866775005914	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
866775005915	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
866775005916	acyl-coenzyme A oxidase; Region: PLN02526
866775005917	active site
866775005918	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
866775005919	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
866775005920	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
866775005921	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
866775005922	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
866775005923	G-X-X-G motif; other site
866775005924	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
866775005925	RxxxH motif; other site
866775005926	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
866775005927	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
866775005928	ribonuclease P; Reviewed; Region: rnpA; PRK00499
866775005929	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
866775005930	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
866775005931	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
866775005932	tetramer interface [polypeptide binding]; other site
866775005933	TPP-binding site [chemical binding]; other site
866775005934	heterodimer interface [polypeptide binding]; other site
866775005935	phosphorylation loop region [posttranslational modification]
866775005936	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
866775005937	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
866775005938	alpha subunit interface [polypeptide binding]; other site
866775005939	TPP binding site [chemical binding]; other site
866775005940	heterodimer interface [polypeptide binding]; other site
866775005941	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
866775005942	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
866775005943	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
866775005944	E3 interaction surface; other site
866775005945	lipoyl attachment site [posttranslational modification]; other site
866775005946	e3 binding domain; Region: E3_binding; pfam02817
866775005947	e3 binding domain; Region: E3_binding; pfam02817
866775005948	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
866775005949	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
866775005950	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303