-- dump date   	20140618_192200
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1288394000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1288394000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1288394000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394000004	Walker A motif; other site
1288394000005	ATP binding site [chemical binding]; other site
1288394000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1288394000007	Walker B motif; other site
1288394000008	arginine finger; other site
1288394000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1288394000010	DnaA box-binding interface [nucleotide binding]; other site
1288394000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
1288394000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1288394000013	putative DNA binding surface [nucleotide binding]; other site
1288394000014	dimer interface [polypeptide binding]; other site
1288394000015	beta-clamp/clamp loader binding surface; other site
1288394000016	beta-clamp/translesion DNA polymerase binding surface; other site
1288394000017	recombination protein F; Reviewed; Region: recF; PRK00064
1288394000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394000019	Walker A/P-loop; other site
1288394000020	ATP binding site [chemical binding]; other site
1288394000021	Q-loop/lid; other site
1288394000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394000023	ABC transporter signature motif; other site
1288394000024	Walker B; other site
1288394000025	D-loop; other site
1288394000026	H-loop/switch region; other site
1288394000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1288394000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000029	ATP binding site [chemical binding]; other site
1288394000030	Mg2+ binding site [ion binding]; other site
1288394000031	G-X-G motif; other site
1288394000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1288394000033	anchoring element; other site
1288394000034	dimer interface [polypeptide binding]; other site
1288394000035	ATP binding site [chemical binding]; other site
1288394000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1288394000037	active site
1288394000038	putative metal-binding site [ion binding]; other site
1288394000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1288394000040	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261
1288394000041	putative dimer interface [polypeptide binding]; other site
1288394000042	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394000043	Predicted transcriptional regulator [Transcription]; Region: COG2378
1288394000044	HTH domain; Region: HTH_11; pfam08279
1288394000045	WYL domain; Region: WYL; pfam13280
1288394000046	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1288394000047	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1288394000048	putative dimer interface [polypeptide binding]; other site
1288394000049	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1288394000050	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1288394000051	putative dimer interface [polypeptide binding]; other site
1288394000052	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1288394000053	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394000054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394000055	homodimer interface [polypeptide binding]; other site
1288394000056	catalytic residue [active]
1288394000057	Cupin domain; Region: Cupin_2; cl17218
1288394000058	Helix-turn-helix domain; Region: HTH_18; pfam12833
1288394000059	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394000060	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1288394000061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394000062	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394000063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000064	active site
1288394000065	phosphorylation site [posttranslational modification]
1288394000066	intermolecular recognition site; other site
1288394000067	dimerization interface [polypeptide binding]; other site
1288394000068	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394000069	DNA binding site [nucleotide binding]
1288394000070	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1288394000071	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1288394000072	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1288394000073	Ligand Binding Site [chemical binding]; other site
1288394000074	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1288394000075	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394000076	dimer interface [polypeptide binding]; other site
1288394000077	phosphorylation site [posttranslational modification]
1288394000078	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000079	ATP binding site [chemical binding]; other site
1288394000080	Mg2+ binding site [ion binding]; other site
1288394000081	G-X-G motif; other site
1288394000082	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1288394000083	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1288394000084	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1288394000085	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1288394000086	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1288394000087	glutathione reductase; Validated; Region: PRK06116
1288394000088	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394000089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394000090	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1288394000091	HAMP domain; Region: HAMP; pfam00672
1288394000092	PAS domain; Region: PAS_9; pfam13426
1288394000093	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394000094	putative active site [active]
1288394000095	heme pocket [chemical binding]; other site
1288394000096	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394000097	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000098	ATP binding site [chemical binding]; other site
1288394000099	Mg2+ binding site [ion binding]; other site
1288394000100	G-X-G motif; other site
1288394000101	multidrug efflux protein; Reviewed; Region: PRK09579
1288394000102	Protein export membrane protein; Region: SecD_SecF; cl14618
1288394000103	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1288394000104	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394000105	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394000106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394000107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394000108	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1288394000109	Ricin-type beta-trefoil; Region: RICIN; smart00458
1288394000110	putative sugar binding sites [chemical binding]; other site
1288394000111	Q-X-W motif; other site
1288394000112	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1288394000113	domain interfaces; other site
1288394000114	active site
1288394000115	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
1288394000116	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394000117	putative substrate translocation pore; other site
1288394000118	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1288394000119	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1288394000120	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
1288394000121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394000122	dimerization interface [polypeptide binding]; other site
1288394000123	PAS domain; Region: PAS_9; pfam13426
1288394000124	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394000125	putative active site [active]
1288394000126	heme pocket [chemical binding]; other site
1288394000127	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000128	ATP binding site [chemical binding]; other site
1288394000129	G-X-G motif; other site
1288394000130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000131	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1288394000132	active site
1288394000133	phosphorylation site [posttranslational modification]
1288394000134	intermolecular recognition site; other site
1288394000135	dimerization interface [polypeptide binding]; other site
1288394000136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1288394000137	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394000138	putative hydrolase; Provisional; Region: PRK10976
1288394000139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394000140	active site
1288394000141	motif I; other site
1288394000142	motif II; other site
1288394000143	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1288394000144	lysophospholipase L2; Provisional; Region: PRK10749
1288394000145	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1288394000146	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1288394000147	trimer interface [polypeptide binding]; other site
1288394000148	active site
1288394000149	CoA binding site [chemical binding]; other site
1288394000150	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
1288394000151	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1288394000152	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
1288394000153	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
1288394000154	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394000155	Zn2+ binding site [ion binding]; other site
1288394000156	Mg2+ binding site [ion binding]; other site
1288394000157	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1288394000158	synthetase active site [active]
1288394000159	NTP binding site [chemical binding]; other site
1288394000160	metal binding site [ion binding]; metal-binding site
1288394000161	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1288394000162	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1288394000163	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1288394000164	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1288394000165	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1288394000166	catalytic site [active]
1288394000167	G-X2-G-X-G-K; other site
1288394000168	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394000169	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1288394000170	putative active site [active]
1288394000171	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
1288394000172	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; pfam06293
1288394000173	PAS fold; Region: PAS_3; pfam08447
1288394000174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394000175	putative active site [active]
1288394000176	heme pocket [chemical binding]; other site
1288394000177	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394000178	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394000179	metal binding site [ion binding]; metal-binding site
1288394000180	active site
1288394000181	I-site; other site
1288394000182	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1288394000183	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1288394000184	EamA-like transporter family; Region: EamA; pfam00892
1288394000185	EamA-like transporter family; Region: EamA; pfam00892
1288394000186	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394000187	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394000188	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394000189	substrate binding pocket [chemical binding]; other site
1288394000190	dimerization interface [polypeptide binding]; other site
1288394000191	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1288394000192	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1288394000193	active site
1288394000194	HIGH motif; other site
1288394000195	dimer interface [polypeptide binding]; other site
1288394000196	KMSKS motif; other site
1288394000197	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1288394000198	Ligand Binding Site [chemical binding]; other site
1288394000199	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
1288394000200	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
1288394000201	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
1288394000202	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
1288394000203	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394000204	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394000205	metal binding site [ion binding]; metal-binding site
1288394000206	active site
1288394000207	I-site; other site
1288394000208	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1288394000209	Ferritin-like domain; Region: Ferritin; pfam00210
1288394000210	ferroxidase diiron center [ion binding]; other site
1288394000211	Predicted flavoproteins [General function prediction only]; Region: COG2081
1288394000212	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
1288394000213	TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721
1288394000214	AAA domain; Region: AAA_22; pfam13401
1288394000215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394000216	non-specific DNA binding site [nucleotide binding]; other site
1288394000217	salt bridge; other site
1288394000218	sequence-specific DNA binding site [nucleotide binding]; other site
1288394000219	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1288394000220	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1288394000221	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1288394000222	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1288394000223	Helix-turn-helix domain; Region: HTH_17; cl17695
1288394000224	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1288394000225	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1288394000226	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394000227	ATP binding site [chemical binding]; other site
1288394000228	putative Mg++ binding site [ion binding]; other site
1288394000229	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1288394000230	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1288394000231	active site
1288394000232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394000233	AAA domain; Region: AAA_23; pfam13476
1288394000234	Walker A/P-loop; other site
1288394000235	ATP binding site [chemical binding]; other site
1288394000236	AAA domain; Region: AAA_21; pfam13304
1288394000237	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
1288394000238	Divergent AAA domain; Region: AAA_4; pfam04326
1288394000239	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
1288394000240	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1288394000241	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1288394000242	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1288394000243	AAA domain; Region: AAA_13; pfam13166
1288394000244	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1288394000245	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1288394000246	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1288394000247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394000248	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394000249	putative substrate translocation pore; other site
1288394000250	leucine export protein LeuE; Provisional; Region: PRK10958
1288394000251	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1288394000252	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
1288394000253	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1288394000254	putative fimbrial protein TcfA; Provisional; Region: PRK15308
1288394000255	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1288394000256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000257	active site
1288394000258	phosphorylation site [posttranslational modification]
1288394000259	intermolecular recognition site; other site
1288394000260	dimerization interface [polypeptide binding]; other site
1288394000261	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394000262	DNA binding residues [nucleotide binding]
1288394000263	dimerization interface [polypeptide binding]; other site
1288394000264	hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959
1288394000265	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394000266	substrate binding pocket [chemical binding]; other site
1288394000267	membrane-bound complex binding site; other site
1288394000268	hinge residues; other site
1288394000269	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394000270	substrate binding pocket [chemical binding]; other site
1288394000271	membrane-bound complex binding site; other site
1288394000272	hinge residues; other site
1288394000273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394000274	dimer interface [polypeptide binding]; other site
1288394000275	phosphorylation site [posttranslational modification]
1288394000276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000277	ATP binding site [chemical binding]; other site
1288394000278	Mg2+ binding site [ion binding]; other site
1288394000279	G-X-G motif; other site
1288394000280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000281	active site
1288394000282	phosphorylation site [posttranslational modification]
1288394000283	intermolecular recognition site; other site
1288394000284	dimerization interface [polypeptide binding]; other site
1288394000285	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394000286	putative binding surface; other site
1288394000287	active site
1288394000288	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1288394000289	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1288394000290	GAF domain; Region: GAF_3; pfam13492
1288394000291	Histidine kinase; Region: His_kinase; pfam06580
1288394000292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000293	ATP binding site [chemical binding]; other site
1288394000294	Mg2+ binding site [ion binding]; other site
1288394000295	G-X-G motif; other site
1288394000296	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1288394000297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000298	active site
1288394000299	phosphorylation site [posttranslational modification]
1288394000300	intermolecular recognition site; other site
1288394000301	dimerization interface [polypeptide binding]; other site
1288394000302	LytTr DNA-binding domain; Region: LytTR; smart00850
1288394000303	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1288394000304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394000305	putative substrate translocation pore; other site
1288394000306	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1288394000307	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1288394000308	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1288394000309	Domain of unknown function (DUF897); Region: DUF897; cl01312
1288394000310	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1288394000311	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394000312	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394000313	dimerization interface [polypeptide binding]; other site
1288394000314	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
1288394000315	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394000316	N-terminal plug; other site
1288394000317	ligand-binding site [chemical binding]; other site
1288394000318	glutamate racemase; Provisional; Region: PRK00865
1288394000319	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1288394000320	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1288394000321	cytosine deaminase; Provisional; Region: PRK09230
1288394000322	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1288394000323	active site
1288394000324	camphor resistance protein CrcB; Provisional; Region: PRK14197
1288394000325	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1288394000326	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394000327	S-adenosylmethionine binding site [chemical binding]; other site
1288394000328	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
1288394000329	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1288394000330	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
1288394000331	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1288394000332	twin arginine translocase protein A; Provisional; Region: tatA; PRK04598
1288394000333	sec-independent translocase; Provisional; Region: PRK01770
1288394000334	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1288394000335	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1288394000336	active site
1288394000337	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1288394000338	dimer interface [polypeptide binding]; other site
1288394000339	allosteric magnesium binding site [ion binding]; other site
1288394000340	active site
1288394000341	aspartate-rich active site metal binding site; other site
1288394000342	Schiff base residues; other site
1288394000343	oligopeptidase A; Provisional; Region: PRK10911
1288394000344	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1288394000345	active site
1288394000346	Zn binding site [ion binding]; other site
1288394000347	PAS domain S-box; Region: sensory_box; TIGR00229
1288394000348	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394000349	putative active site [active]
1288394000350	heme pocket [chemical binding]; other site
1288394000351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394000352	PAS domain; Region: PAS_9; pfam13426
1288394000353	putative active site [active]
1288394000354	heme pocket [chemical binding]; other site
1288394000355	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394000356	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394000357	metal binding site [ion binding]; metal-binding site
1288394000358	active site
1288394000359	I-site; other site
1288394000360	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394000361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394000362	S-adenosylmethionine binding site [chemical binding]; other site
1288394000363	Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210
1288394000364	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
1288394000365	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
1288394000366	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1288394000367	nucleotide binding site [chemical binding]; other site
1288394000368	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1288394000369	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394000370	ATP binding site [chemical binding]; other site
1288394000371	Mg++ binding site [ion binding]; other site
1288394000372	motif III; other site
1288394000373	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394000374	nucleotide binding region [chemical binding]; other site
1288394000375	ATP-binding site [chemical binding]; other site
1288394000376	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1288394000377	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1288394000378	catalytic residues [active]
1288394000379	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1288394000380	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1288394000381	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1288394000382	RNA binding site [nucleotide binding]; other site
1288394000383	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1288394000384	multimer interface [polypeptide binding]; other site
1288394000385	Walker A motif; other site
1288394000386	ATP binding site [chemical binding]; other site
1288394000387	Walker B motif; other site
1288394000388	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1288394000389	FMN reductase; Validated; Region: fre; PRK08051
1288394000390	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
1288394000391	FAD binding pocket [chemical binding]; other site
1288394000392	FAD binding motif [chemical binding]; other site
1288394000393	phosphate binding motif [ion binding]; other site
1288394000394	beta-alpha-beta structure motif; other site
1288394000395	NAD binding pocket [chemical binding]; other site
1288394000396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
1288394000397	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
1288394000398	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
1288394000399	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
1288394000400	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
1288394000401	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1288394000402	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
1288394000403	active site residue [active]
1288394000404	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394000405	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1288394000406	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394000407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394000408	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394000409	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
1288394000410	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1288394000411	Walker A/P-loop; other site
1288394000412	ATP binding site [chemical binding]; other site
1288394000413	Q-loop/lid; other site
1288394000414	ABC transporter signature motif; other site
1288394000415	Walker B; other site
1288394000416	D-loop; other site
1288394000417	H-loop/switch region; other site
1288394000418	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
1288394000419	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1288394000420	Walker A/P-loop; other site
1288394000421	ATP binding site [chemical binding]; other site
1288394000422	Q-loop/lid; other site
1288394000423	ABC transporter signature motif; other site
1288394000424	Walker B; other site
1288394000425	D-loop; other site
1288394000426	H-loop/switch region; other site
1288394000427	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
1288394000428	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
1288394000429	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1288394000430	TM-ABC transporter signature motif; other site
1288394000431	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394000432	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1288394000433	TM-ABC transporter signature motif; other site
1288394000434	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1288394000435	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1288394000436	dimerization interface [polypeptide binding]; other site
1288394000437	ligand binding site [chemical binding]; other site
1288394000438	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1288394000439	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394000440	DNA binding site [nucleotide binding]
1288394000441	domain linker motif; other site
1288394000442	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1288394000443	dimerization interface [polypeptide binding]; other site
1288394000444	ligand binding site [chemical binding]; other site
1288394000445	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1288394000446	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
1288394000447	NAD binding site [chemical binding]; other site
1288394000448	sugar binding site [chemical binding]; other site
1288394000449	divalent metal binding site [ion binding]; other site
1288394000450	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1288394000451	dimer interface [polypeptide binding]; other site
1288394000452	PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852
1288394000453	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1288394000454	PTS system arbutin-specific transporter subunit IIB; Provisional; Region: PRK09702
1288394000455	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394000456	active site turn [active]
1288394000457	phosphorylation site [posttranslational modification]
1288394000458	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1288394000459	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394000460	DNA-binding site [nucleotide binding]; DNA binding site
1288394000461	UTRA domain; Region: UTRA; pfam07702
1288394000462	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1288394000463	GAF domain; Region: GAF; pfam01590
1288394000464	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394000465	Walker A motif; other site
1288394000466	ATP binding site [chemical binding]; other site
1288394000467	Walker B motif; other site
1288394000468	arginine finger; other site
1288394000469	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
1288394000470	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1288394000471	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1288394000472	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1288394000473	iron binding site [ion binding]; other site
1288394000474	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
1288394000475	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394000476	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
1288394000477	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1288394000478	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1288394000479	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1288394000480	aromatic amino acid transport protein; Region: araaP; TIGR00837
1288394000481	Electron transfer DM13; Region: DM13; pfam10517
1288394000482	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1288394000483	Predicted kinase [General function prediction only]; Region: COG0645
1288394000484	AAA domain; Region: AAA_17; pfam13207
1288394000485	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1288394000486	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1288394000487	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1288394000488	dimer interface [polypeptide binding]; other site
1288394000489	motif 1; other site
1288394000490	active site
1288394000491	motif 2; other site
1288394000492	motif 3; other site
1288394000493	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1288394000494	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394000495	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1288394000496	catalytic triad [active]
1288394000497	conserved cis-peptide bond; other site
1288394000498	putative outer membrane lipoprotein; Provisional; Region: PRK10510
1288394000499	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394000500	ligand binding site [chemical binding]; other site
1288394000501	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1288394000502	homotrimer interaction site [polypeptide binding]; other site
1288394000503	putative active site [active]
1288394000504	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
1288394000505	CPxP  motif; other site
1288394000506	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1288394000507	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1288394000508	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394000509	dimerization interface [polypeptide binding]; other site
1288394000510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000511	ATP binding site [chemical binding]; other site
1288394000512	Mg2+ binding site [ion binding]; other site
1288394000513	G-X-G motif; other site
1288394000514	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394000515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000516	active site
1288394000517	phosphorylation site [posttranslational modification]
1288394000518	intermolecular recognition site; other site
1288394000519	dimerization interface [polypeptide binding]; other site
1288394000520	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394000521	DNA binding site [nucleotide binding]
1288394000522	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
1288394000523	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1288394000524	dimer interface [polypeptide binding]; other site
1288394000525	active site
1288394000526	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1288394000527	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394000528	substrate binding site [chemical binding]; other site
1288394000529	oxyanion hole (OAH) forming residues; other site
1288394000530	trimer interface [polypeptide binding]; other site
1288394000531	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1288394000532	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1288394000533	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1288394000534	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
1288394000535	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
1288394000536	acyl-activating enzyme (AAE) consensus motif; other site
1288394000537	putative AMP binding site [chemical binding]; other site
1288394000538	putative active site [active]
1288394000539	putative CoA binding site [chemical binding]; other site
1288394000540	proline dipeptidase; Provisional; Region: PRK13607
1288394000541	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1288394000542	active site
1288394000543	hypothetical protein; Provisional; Region: PRK11568
1288394000544	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1288394000545	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1288394000546	Cation transport protein; Region: TrkH; cl17365
1288394000547	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1288394000548	Flavodoxin domain; Region: Flavodoxin_5; cl17428
1288394000549	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1288394000550	CoA binding domain; Region: CoA_binding_2; pfam13380
1288394000551	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1288394000552	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1288394000553	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394000554	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1288394000555	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394000556	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394000557	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
1288394000558	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
1288394000559	putative dimerization interface [polypeptide binding]; other site
1288394000560	ketol-acid reductoisomerase; Validated; Region: PRK05225
1288394000561	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1288394000562	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1288394000563	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1288394000564	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1288394000565	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1288394000566	active site
1288394000567	dimer interface [polypeptide binding]; other site
1288394000568	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1288394000569	dimer interface [polypeptide binding]; other site
1288394000570	active site
1288394000571	mechanosensitive channel MscS; Provisional; Region: PRK10334
1288394000572	Conserved TM helix; Region: TM_helix; pfam05552
1288394000573	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394000574	division inhibitor protein; Provisional; Region: slmA; PRK09480
1288394000575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394000576	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1288394000577	trimer interface [polypeptide binding]; other site
1288394000578	active site
1288394000579	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1288394000580	Flavoprotein; Region: Flavoprotein; pfam02441
1288394000581	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1288394000582	hypothetical protein; Reviewed; Region: PRK00024
1288394000583	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1288394000584	MPN+ (JAMM) motif; other site
1288394000585	Zinc-binding site [ion binding]; other site
1288394000586	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1288394000587	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1288394000588	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1288394000589	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1288394000590	DNA binding site [nucleotide binding]
1288394000591	catalytic residue [active]
1288394000592	H2TH interface [polypeptide binding]; other site
1288394000593	putative catalytic residues [active]
1288394000594	turnover-facilitating residue; other site
1288394000595	intercalation triad [nucleotide binding]; other site
1288394000596	8OG recognition residue [nucleotide binding]; other site
1288394000597	putative reading head residues; other site
1288394000598	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1288394000599	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1288394000600	Protein of unknown function (DUF535); Region: DUF535; pfam04393
1288394000601	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1288394000602	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1288394000603	active site
1288394000604	(T/H)XGH motif; other site
1288394000605	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394000606	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1288394000607	putative active site [active]
1288394000608	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1288394000609	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1288394000610	putative metal binding site; other site
1288394000611	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394000612	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1288394000613	putative active site [active]
1288394000614	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
1288394000615	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1288394000616	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394000617	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
1288394000618	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
1288394000619	active site
1288394000620	P-loop; other site
1288394000621	phosphorylation site [posttranslational modification]
1288394000622	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394000623	active site
1288394000624	phosphorylation site [posttranslational modification]
1288394000625	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1288394000626	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394000627	DNA binding site [nucleotide binding]
1288394000628	domain linker motif; other site
1288394000629	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1288394000630	putative dimerization interface [polypeptide binding]; other site
1288394000631	putative ligand binding site [chemical binding]; other site
1288394000632	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1288394000633	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1288394000634	NADP binding site [chemical binding]; other site
1288394000635	dimer interface [polypeptide binding]; other site
1288394000636	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
1288394000637	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
1288394000638	Chorismate lyase; Region: Chor_lyase; cl01230
1288394000639	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
1288394000640	UbiA prenyltransferase family; Region: UbiA; pfam01040
1288394000641	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1288394000642	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1288394000643	putative acyl-acceptor binding pocket; other site
1288394000644	LexA repressor; Validated; Region: PRK00215
1288394000645	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1288394000646	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1288394000647	Catalytic site [active]
1288394000648	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1288394000649	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1288394000650	Cu(I) binding site [ion binding]; other site
1288394000651	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1288394000652	putative efflux protein, MATE family; Region: matE; TIGR00797
1288394000653	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1288394000654	two-component sensor protein; Provisional; Region: cpxA; PRK09470
1288394000655	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394000656	dimerization interface [polypeptide binding]; other site
1288394000657	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394000658	dimer interface [polypeptide binding]; other site
1288394000659	phosphorylation site [posttranslational modification]
1288394000660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000661	ATP binding site [chemical binding]; other site
1288394000662	Mg2+ binding site [ion binding]; other site
1288394000663	G-X-G motif; other site
1288394000664	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
1288394000665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000666	active site
1288394000667	phosphorylation site [posttranslational modification]
1288394000668	intermolecular recognition site; other site
1288394000669	dimerization interface [polypeptide binding]; other site
1288394000670	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394000671	DNA binding site [nucleotide binding]
1288394000672	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1288394000673	Cation efflux family; Region: Cation_efflux; cl00316
1288394000674	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1288394000675	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1288394000676	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1288394000677	trimer interface [polypeptide binding]; other site
1288394000678	active site
1288394000679	substrate binding site [chemical binding]; other site
1288394000680	CoA binding site [chemical binding]; other site
1288394000681	Protein of unknown function (DUF904); Region: DUF904; pfam06005
1288394000682	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
1288394000683	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
1288394000684	conserved cys residue [active]
1288394000685	DNA polymerase I; Provisional; Region: PRK05755
1288394000686	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1288394000687	active site
1288394000688	metal binding site 1 [ion binding]; metal-binding site
1288394000689	putative 5' ssDNA interaction site; other site
1288394000690	metal binding site 3; metal-binding site
1288394000691	metal binding site 2 [ion binding]; metal-binding site
1288394000692	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1288394000693	putative DNA binding site [nucleotide binding]; other site
1288394000694	putative metal binding site [ion binding]; other site
1288394000695	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1288394000696	active site
1288394000697	catalytic site [active]
1288394000698	substrate binding site [chemical binding]; other site
1288394000699	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1288394000700	active site
1288394000701	DNA binding site [nucleotide binding]
1288394000702	catalytic site [active]
1288394000703	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1288394000704	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1288394000705	trimer interface [polypeptide binding]; other site
1288394000706	putative metal binding site [ion binding]; other site
1288394000707	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1288394000708	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394000709	DNA binding site [nucleotide binding]
1288394000710	domain linker motif; other site
1288394000711	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1288394000712	putative dimerization interface [polypeptide binding]; other site
1288394000713	putative ligand binding site [chemical binding]; other site
1288394000714	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1288394000715	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1288394000716	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1288394000717	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1288394000718	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1288394000719	Domain of unknown function (DUF386); Region: DUF386; cl01047
1288394000720	inner membrane transporter YjeM; Provisional; Region: PRK15238
1288394000721	tRNA-binding protein; Provisional; Region: PRK10089
1288394000722	putative tRNA-binding site [nucleotide binding]; other site
1288394000723	inner membrane transporter YjeM; Provisional; Region: PRK15238
1288394000724	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1288394000725	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1288394000726	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
1288394000727	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1288394000728	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1288394000729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394000730	S-adenosylmethionine binding site [chemical binding]; other site
1288394000731	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1288394000732	S-formylglutathione hydrolase; Region: PLN02442
1288394000733	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1288394000734	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1288394000735	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1288394000736	substrate binding site [chemical binding]; other site
1288394000737	catalytic Zn binding site [ion binding]; other site
1288394000738	NAD binding site [chemical binding]; other site
1288394000739	structural Zn binding site [ion binding]; other site
1288394000740	dimer interface [polypeptide binding]; other site
1288394000741	LysR family transcriptional regulator; Provisional; Region: PRK14997
1288394000742	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394000743	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
1288394000744	putative effector binding pocket; other site
1288394000745	putative dimerization interface [polypeptide binding]; other site
1288394000746	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394000747	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1288394000748	TM-ABC transporter signature motif; other site
1288394000749	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1288394000750	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394000751	TM-ABC transporter signature motif; other site
1288394000752	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1288394000753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394000754	Walker A/P-loop; other site
1288394000755	ATP binding site [chemical binding]; other site
1288394000756	Q-loop/lid; other site
1288394000757	ABC transporter signature motif; other site
1288394000758	Walker B; other site
1288394000759	D-loop; other site
1288394000760	H-loop/switch region; other site
1288394000761	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1288394000762	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1288394000763	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1288394000764	ligand binding site [chemical binding]; other site
1288394000765	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
1288394000766	Part of AAA domain; Region: AAA_19; pfam13245
1288394000767	Family description; Region: UvrD_C_2; pfam13538
1288394000768	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
1288394000769	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394000770	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394000771	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394000772	putative effector binding pocket; other site
1288394000773	dimerization interface [polypeptide binding]; other site
1288394000774	putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318
1288394000775	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
1288394000776	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
1288394000777	putative hydrophobic ligand binding site [chemical binding]; other site
1288394000778	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
1288394000779	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
1288394000780	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
1288394000781	transcriptional regulator; Provisional; Region: PRK10632
1288394000782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394000783	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394000784	dimerization interface [polypeptide binding]; other site
1288394000785	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394000786	Sulphur transport; Region: Sulf_transp; pfam04143
1288394000787	magnesium-transporting ATPase; Provisional; Region: PRK15122
1288394000788	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1288394000789	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1288394000790	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1288394000791	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1288394000792	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1288394000793	LysE type translocator; Region: LysE; cl00565
1288394000794	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1288394000795	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394000796	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394000797	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394000798	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
1288394000799	EamA-like transporter family; Region: EamA; pfam00892
1288394000800	gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847
1288394000801	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1288394000802	NAD(P) binding site [chemical binding]; other site
1288394000803	catalytic residues [active]
1288394000804	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1288394000805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394000806	non-specific DNA binding site [nucleotide binding]; other site
1288394000807	salt bridge; other site
1288394000808	sequence-specific DNA binding site [nucleotide binding]; other site
1288394000809	Cupin domain; Region: Cupin_2; pfam07883
1288394000810	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
1288394000811	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394000812	inhibitor-cofactor binding pocket; inhibition site
1288394000813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394000814	catalytic residue [active]
1288394000815	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1288394000816	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1288394000817	tetrameric interface [polypeptide binding]; other site
1288394000818	NAD binding site [chemical binding]; other site
1288394000819	catalytic residues [active]
1288394000820	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1288394000821	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1288394000822	catalytic triad [active]
1288394000823	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1288394000824	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1288394000825	hexamer interface [polypeptide binding]; other site
1288394000826	ligand binding site [chemical binding]; other site
1288394000827	putative active site [active]
1288394000828	NAD(P) binding site [chemical binding]; other site
1288394000829	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1288394000830	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1288394000831	substrate binding site [chemical binding]; other site
1288394000832	ATP binding site [chemical binding]; other site
1288394000833	Predicted transcriptional regulator [Transcription]; Region: COG1959
1288394000834	Transcriptional regulator; Region: Rrf2; cl17282
1288394000835	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394000836	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394000837	RmuC family; Region: RmuC; pfam02646
1288394000838	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1288394000839	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1288394000840	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1288394000841	TrkA-N domain; Region: TrkA_N; pfam02254
1288394000842	TrkA-C domain; Region: TrkA_C; pfam02080
1288394000843	TrkA-N domain; Region: TrkA_N; pfam02254
1288394000844	TrkA-C domain; Region: TrkA_C; pfam02080
1288394000845	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1288394000846	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1288394000847	putative RNA binding site [nucleotide binding]; other site
1288394000848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394000849	S-adenosylmethionine binding site [chemical binding]; other site
1288394000850	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1288394000851	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1288394000852	putative active site [active]
1288394000853	substrate binding site [chemical binding]; other site
1288394000854	putative cosubstrate binding site; other site
1288394000855	catalytic site [active]
1288394000856	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1288394000857	substrate binding site [chemical binding]; other site
1288394000858	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1288394000859	active site
1288394000860	catalytic residues [active]
1288394000861	metal binding site [ion binding]; metal-binding site
1288394000862	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1288394000863	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394000864	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1288394000865	DNA protecting protein DprA; Region: dprA; TIGR00732
1288394000866	Protein of unknown function (DUF494); Region: DUF494; pfam04361
1288394000867	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1288394000868	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
1288394000869	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1288394000870	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1288394000871	AIR carboxylase; Region: AIRC; pfam00731
1288394000872	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1288394000873	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1288394000874	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1288394000875	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1288394000876	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1288394000877	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1288394000878	shikimate binding site; other site
1288394000879	NAD(P) binding site [chemical binding]; other site
1288394000880	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
1288394000881	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1288394000882	GTP/Mg2+ binding site [chemical binding]; other site
1288394000883	Switch I region; other site
1288394000884	G2 box; other site
1288394000885	G3 box; other site
1288394000886	Switch II region; other site
1288394000887	G4 box; other site
1288394000888	G5 box; other site
1288394000889	Cytochrome c553 [Energy production and conversion]; Region: COG2863
1288394000890	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1288394000891	Cytochrome c; Region: Cytochrom_C; cl11414
1288394000892	Der GTPase activator (YihI); Region: YihI; pfam04220
1288394000893	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
1288394000894	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1288394000895	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394000896	FeS/SAM binding site; other site
1288394000897	HemN C-terminal domain; Region: HemN_C; pfam06969
1288394000898	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1288394000899	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1288394000900	active site
1288394000901	purine riboside binding site [chemical binding]; other site
1288394000902	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
1288394000903	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394000904	active site
1288394000905	phosphorylation site [posttranslational modification]
1288394000906	intermolecular recognition site; other site
1288394000907	dimerization interface [polypeptide binding]; other site
1288394000908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394000909	Walker A motif; other site
1288394000910	ATP binding site [chemical binding]; other site
1288394000911	Walker B motif; other site
1288394000912	arginine finger; other site
1288394000913	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394000914	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
1288394000915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394000916	putative active site [active]
1288394000917	heme pocket [chemical binding]; other site
1288394000918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394000919	ATP binding site [chemical binding]; other site
1288394000920	Mg2+ binding site [ion binding]; other site
1288394000921	G-X-G motif; other site
1288394000922	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
1288394000923	glutamine synthetase; Provisional; Region: glnA; PRK09469
1288394000924	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1288394000925	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1288394000926	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1288394000927	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1288394000928	G1 box; other site
1288394000929	putative GEF interaction site [polypeptide binding]; other site
1288394000930	GTP/Mg2+ binding site [chemical binding]; other site
1288394000931	Switch I region; other site
1288394000932	G2 box; other site
1288394000933	G3 box; other site
1288394000934	Switch II region; other site
1288394000935	G4 box; other site
1288394000936	G5 box; other site
1288394000937	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1288394000938	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1288394000939	hypothetical protein; Reviewed; Region: PRK01637
1288394000940	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1288394000941	putative active site [active]
1288394000942	dimerization interface [polypeptide binding]; other site
1288394000943	putative tRNAtyr binding site [nucleotide binding]; other site
1288394000944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394000945	S-adenosylmethionine binding site [chemical binding]; other site
1288394000946	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394000947	Coenzyme A binding pocket [chemical binding]; other site
1288394000948	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
1288394000949	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1288394000950	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1288394000951	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1288394000952	ssDNA binding site; other site
1288394000953	generic binding surface II; other site
1288394000954	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394000955	ATP binding site [chemical binding]; other site
1288394000956	putative Mg++ binding site [ion binding]; other site
1288394000957	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394000958	nucleotide binding region [chemical binding]; other site
1288394000959	ATP-binding site [chemical binding]; other site
1288394000960	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
1288394000961	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
1288394000962	domain interface [polypeptide binding]; other site
1288394000963	putative active site [active]
1288394000964	catalytic site [active]
1288394000965	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
1288394000966	domain interface [polypeptide binding]; other site
1288394000967	putative active site [active]
1288394000968	catalytic site [active]
1288394000969	low affinity gluconate transporter; Provisional; Region: PRK10472
1288394000970	GntP family permease; Region: GntP_permease; pfam02447
1288394000971	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1288394000972	ATP-binding site [chemical binding]; other site
1288394000973	Gluconate-6-phosphate binding site [chemical binding]; other site
1288394000974	Shikimate kinase; Region: SKI; pfam01202
1288394000975	phosphogluconate dehydratase; Validated; Region: PRK09054
1288394000976	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1288394000977	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1288394000978	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1288394000979	active site
1288394000980	intersubunit interface [polypeptide binding]; other site
1288394000981	catalytic residue [active]
1288394000982	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
1288394000983	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394000984	DNA binding site [nucleotide binding]
1288394000985	domain linker motif; other site
1288394000986	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1288394000987	putative ligand binding site [chemical binding]; other site
1288394000988	putative dimerization interface [polypeptide binding]; other site
1288394000989	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1288394000990	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1288394000991	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1288394000992	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1288394000993	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394000994	phosphoglyceromutase; Provisional; Region: PRK05434
1288394000995	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1288394000996	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1288394000997	active site residue [active]
1288394000998	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
1288394000999	SecA binding site; other site
1288394001000	Preprotein binding site; other site
1288394001001	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1288394001002	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1288394001003	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1288394001004	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
1288394001005	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1288394001006	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1288394001007	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1288394001008	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394001009	active site
1288394001010	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
1288394001011	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1288394001012	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
1288394001013	SprA-related family; Region: SprA-related; pfam12118
1288394001014	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1288394001015	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1288394001016	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1288394001017	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1288394001018	RNA binding site [nucleotide binding]; other site
1288394001019	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
1288394001020	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1288394001021	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1288394001022	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1288394001023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394001024	active site
1288394001025	phosphorylation site [posttranslational modification]
1288394001026	intermolecular recognition site; other site
1288394001027	dimerization interface [polypeptide binding]; other site
1288394001028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394001029	DNA binding site [nucleotide binding]
1288394001030	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
1288394001031	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394001032	dimerization interface [polypeptide binding]; other site
1288394001033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394001034	dimer interface [polypeptide binding]; other site
1288394001035	phosphorylation site [posttranslational modification]
1288394001036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394001037	ATP binding site [chemical binding]; other site
1288394001038	Mg2+ binding site [ion binding]; other site
1288394001039	G-X-G motif; other site
1288394001040	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394001041	EamA-like transporter family; Region: EamA; pfam00892
1288394001042	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1288394001043	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1288394001044	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1288394001045	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1288394001046	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1288394001047	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1288394001048	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1288394001049	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1288394001050	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1288394001051	putative translocon binding site; other site
1288394001052	protein-rRNA interface [nucleotide binding]; other site
1288394001053	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
1288394001054	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1288394001055	G-X-X-G motif; other site
1288394001056	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1288394001057	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1288394001058	23S rRNA interface [nucleotide binding]; other site
1288394001059	5S rRNA interface [nucleotide binding]; other site
1288394001060	putative antibiotic binding site [chemical binding]; other site
1288394001061	L25 interface [polypeptide binding]; other site
1288394001062	L27 interface [polypeptide binding]; other site
1288394001063	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1288394001064	23S rRNA interface [nucleotide binding]; other site
1288394001065	putative translocon interaction site; other site
1288394001066	signal recognition particle (SRP54) interaction site; other site
1288394001067	L23 interface [polypeptide binding]; other site
1288394001068	trigger factor interaction site; other site
1288394001069	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1288394001070	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1288394001071	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1288394001072	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1288394001073	RNA binding site [nucleotide binding]; other site
1288394001074	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1288394001075	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1288394001076	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1288394001077	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1288394001078	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1288394001079	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1288394001080	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1288394001081	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1288394001082	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1288394001083	5S rRNA interface [nucleotide binding]; other site
1288394001084	23S rRNA interface [nucleotide binding]; other site
1288394001085	L5 interface [polypeptide binding]; other site
1288394001086	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1288394001087	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1288394001088	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1288394001089	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1288394001090	23S rRNA binding site [nucleotide binding]; other site
1288394001091	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1288394001092	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1288394001093	SecY translocase; Region: SecY; pfam00344
1288394001094	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1288394001095	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1288394001096	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1288394001097	30S ribosomal protein S11; Validated; Region: PRK05309
1288394001098	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1288394001099	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1288394001100	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394001101	RNA binding surface [nucleotide binding]; other site
1288394001102	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1288394001103	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1288394001104	alphaNTD homodimer interface [polypeptide binding]; other site
1288394001105	alphaNTD - beta interaction site [polypeptide binding]; other site
1288394001106	alphaNTD - beta' interaction site [polypeptide binding]; other site
1288394001107	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1288394001108	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1288394001109	WYL domain; Region: WYL; pfam13280
1288394001110	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
1288394001111	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
1288394001112	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1288394001113	TrkA-N domain; Region: TrkA_N; pfam02254
1288394001114	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1288394001115	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394001116	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394001117	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394001118	dimerization interface [polypeptide binding]; other site
1288394001119	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1288394001120	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394001121	NAD(P) binding site [chemical binding]; other site
1288394001122	active site
1288394001123	Predicted metal-binding protein [General function prediction only]; Region: COG3019
1288394001124	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1288394001125	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1288394001126	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1288394001127	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1288394001128	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
1288394001129	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
1288394001130	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
1288394001131	YhhN-like protein; Region: YhhN; pfam07947
1288394001132	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394001133	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1288394001134	putative substrate translocation pore; other site
1288394001135	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394001136	HlyD family secretion protein; Region: HlyD; pfam00529
1288394001137	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394001138	LysR family transcriptional regulator; Provisional; Region: PRK14997
1288394001139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394001140	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394001141	putative effector binding pocket; other site
1288394001142	dimerization interface [polypeptide binding]; other site
1288394001143	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1288394001144	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1288394001145	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394001146	probable metal-binding protein; Region: matur_matur; TIGR03853
1288394001147	putative antibiotic transporter; Provisional; Region: PRK10739
1288394001148	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
1288394001149	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394001150	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394001151	substrate binding pocket [chemical binding]; other site
1288394001152	dimerization interface [polypeptide binding]; other site
1288394001153	twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411
1288394001154	Protein of unknown function (DUF406); Region: DUF406; pfam04175
1288394001155	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394001156	substrate binding pocket [chemical binding]; other site
1288394001157	membrane-bound complex binding site; other site
1288394001158	hinge residues; other site
1288394001159	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394001160	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394001161	catalytic residue [active]
1288394001162	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1288394001163	PLD-like domain; Region: PLDc_2; pfam13091
1288394001164	putative active site [active]
1288394001165	catalytic site [active]
1288394001166	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1288394001167	PLD-like domain; Region: PLDc_2; pfam13091
1288394001168	putative active site [active]
1288394001169	catalytic site [active]
1288394001170	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1288394001171	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1288394001172	Di-iron ligands [ion binding]; other site
1288394001173	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1288394001174	Domain of unknown function (DUF947); Region: DUF947; pfam06102
1288394001175	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1288394001176	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394001177	Protein of unknown function (DUF1422); Region: DUF1422; pfam07226
1288394001178	Protein of unknown function (DUF1145); Region: DUF1145; pfam06611
1288394001179	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1288394001180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394001181	S-adenosylmethionine binding site [chemical binding]; other site
1288394001182	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1288394001183	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1288394001184	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1288394001185	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1288394001186	P loop; other site
1288394001187	GTP binding site [chemical binding]; other site
1288394001188	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1288394001189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394001190	Walker A/P-loop; other site
1288394001191	ATP binding site [chemical binding]; other site
1288394001192	Q-loop/lid; other site
1288394001193	ABC transporter signature motif; other site
1288394001194	Walker B; other site
1288394001195	D-loop; other site
1288394001196	H-loop/switch region; other site
1288394001197	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
1288394001198	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1288394001199	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1288394001200	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394001201	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394001202	DNA binding residues [nucleotide binding]
1288394001203	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
1288394001204	active site clefts [active]
1288394001205	zinc binding site [ion binding]; other site
1288394001206	dimer interface [polypeptide binding]; other site
1288394001207	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1288394001208	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394001209	DNA-binding site [nucleotide binding]; DNA binding site
1288394001210	UTRA domain; Region: UTRA; pfam07702
1288394001211	imidazolonepropionase; Validated; Region: PRK09356
1288394001212	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1288394001213	active site
1288394001214	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1288394001215	putative active site [active]
1288394001216	putative metal binding site [ion binding]; other site
1288394001217	urocanate hydratase; Provisional; Region: PRK05414
1288394001218	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1288394001219	active sites [active]
1288394001220	tetramer interface [polypeptide binding]; other site
1288394001221	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
1288394001222	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1288394001223	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394001224	regulatory protein CsrD; Provisional; Region: PRK11059
1288394001225	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394001226	metal binding site [ion binding]; metal-binding site
1288394001227	active site
1288394001228	I-site; other site
1288394001229	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394001230	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1288394001231	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1288394001232	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394001233	catalytic residue [active]
1288394001234	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1288394001235	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1288394001236	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1288394001237	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
1288394001238	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1288394001239	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1288394001240	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
1288394001241	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394001242	Walker A motif; other site
1288394001243	ATP binding site [chemical binding]; other site
1288394001244	Walker B motif; other site
1288394001245	arginine finger; other site
1288394001246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394001247	TPR motif; other site
1288394001248	binding surface
1288394001249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1288394001250	TPR motif; other site
1288394001251	binding surface
1288394001252	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1288394001253	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1288394001254	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1288394001255	Walker A motif; other site
1288394001256	ATP binding site [chemical binding]; other site
1288394001257	Walker B motif; other site
1288394001258	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1288394001259	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394001260	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394001261	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1288394001262	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1288394001263	legume lectins; Region: lectin_L-type; cl14058
1288394001264	homotetramer interaction site [polypeptide binding]; other site
1288394001265	homodimer interaction site [polypeptide binding]; other site
1288394001266	carbohydrate binding site [chemical binding]; other site
1288394001267	metal binding site [ion binding]; metal-binding site
1288394001268	rod shape-determining protein MreB; Provisional; Region: PRK13927
1288394001269	MreB and similar proteins; Region: MreB_like; cd10225
1288394001270	nucleotide binding site [chemical binding]; other site
1288394001271	Mg binding site [ion binding]; other site
1288394001272	putative protofilament interaction site [polypeptide binding]; other site
1288394001273	RodZ interaction site [polypeptide binding]; other site
1288394001274	rod shape-determining protein MreC; Provisional; Region: PRK13922
1288394001275	rod shape-determining protein MreC; Region: MreC; pfam04085
1288394001276	rod shape-determining protein MreD; Region: MreD; cl01087
1288394001277	Maf-like protein; Region: Maf; pfam02545
1288394001278	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1288394001279	active site
1288394001280	dimer interface [polypeptide binding]; other site
1288394001281	ribonuclease G; Provisional; Region: PRK11712
1288394001282	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1288394001283	homodimer interface [polypeptide binding]; other site
1288394001284	oligonucleotide binding site [chemical binding]; other site
1288394001285	TIGR02099 family protein; Region: TIGR02099
1288394001286	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1288394001287	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1288394001288	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1288394001289	putative active site [active]
1288394001290	catalytic triad [active]
1288394001291	dimer interface [polypeptide binding]; other site
1288394001292	protease TldD; Provisional; Region: tldD; PRK10735
1288394001293	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1288394001294	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1288394001295	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1288394001296	putative active site [active]
1288394001297	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
1288394001298	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1288394001299	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1288394001300	trimer interface [polypeptide binding]; other site
1288394001301	eyelet of channel; other site
1288394001302	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
1288394001303	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394001304	active site turn [active]
1288394001305	phosphorylation site [posttranslational modification]
1288394001306	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394001307	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1288394001308	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1288394001309	putative active site [active]
1288394001310	inner membrane protein; Provisional; Region: PRK10995
1288394001311	metabolite-proton symporter; Region: 2A0106; TIGR00883
1288394001312	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394001313	putative substrate translocation pore; other site
1288394001314	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
1288394001315	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
1288394001316	Ligand Binding Site [chemical binding]; other site
1288394001317	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1288394001318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394001319	active site
1288394001320	phosphorylation site [posttranslational modification]
1288394001321	intermolecular recognition site; other site
1288394001322	dimerization interface [polypeptide binding]; other site
1288394001323	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394001324	Zn2+ binding site [ion binding]; other site
1288394001325	Mg2+ binding site [ion binding]; other site
1288394001326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394001327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394001328	dimer interface [polypeptide binding]; other site
1288394001329	phosphorylation site [posttranslational modification]
1288394001330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394001331	ATP binding site [chemical binding]; other site
1288394001332	Mg2+ binding site [ion binding]; other site
1288394001333	G-X-G motif; other site
1288394001334	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394001335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394001336	active site
1288394001337	phosphorylation site [posttranslational modification]
1288394001338	intermolecular recognition site; other site
1288394001339	dimerization interface [polypeptide binding]; other site
1288394001340	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394001341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394001342	active site
1288394001343	phosphorylation site [posttranslational modification]
1288394001344	intermolecular recognition site; other site
1288394001345	dimerization interface [polypeptide binding]; other site
1288394001346	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394001347	putative binding surface; other site
1288394001348	active site
1288394001349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1288394001350	ATP binding site [chemical binding]; other site
1288394001351	Mg2+ binding site [ion binding]; other site
1288394001352	G-X-G motif; other site
1288394001353	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1288394001354	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1288394001355	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394001356	PAS domain; Region: PAS_9; pfam13426
1288394001357	putative active site [active]
1288394001358	heme pocket [chemical binding]; other site
1288394001359	PAS domain; Region: PAS_9; pfam13426
1288394001360	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394001361	putative active site [active]
1288394001362	heme pocket [chemical binding]; other site
1288394001363	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1288394001364	Cupin domain; Region: Cupin_2; cl17218
1288394001365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394001366	Helix-turn-helix domain; Region: HTH_18; pfam12833
1288394001367	acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009
1288394001368	Predicted metalloprotease [General function prediction only]; Region: COG2321
1288394001369	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1288394001370	HDOD domain; Region: HDOD; pfam08668
1288394001371	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1288394001372	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394001373	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1288394001374	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1288394001375	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1288394001376	Leucine-rich repeats; other site
1288394001377	Substrate binding site [chemical binding]; other site
1288394001378	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1288394001379	Leucine rich repeat; Region: LRR_8; pfam13855
1288394001380	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394001381	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394001382	DNA binding site [nucleotide binding]
1288394001383	Fimbrial protein; Region: Fimbrial; cl01416
1288394001384	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
1288394001385	active site
1288394001386	NTP binding site [chemical binding]; other site
1288394001387	nucleic acid binding site [nucleotide binding]; other site
1288394001388	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1288394001389	fimbrial chaperone protein StdC; Provisional; Region: PRK15254
1288394001390	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1288394001391	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1288394001392	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
1288394001393	PapC N-terminal domain; Region: PapC_N; pfam13954
1288394001394	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1288394001395	PapC C-terminal domain; Region: PapC_C; pfam13953
1288394001396	outer membrane protein A; Reviewed; Region: PRK10808
1288394001397	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1288394001398	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394001399	ligand binding site [chemical binding]; other site
1288394001400	Fimbrial protein; Region: Fimbrial; cl01416
1288394001401	Protein with unknown function (DUF469); Region: DUF469; cl01237
1288394001402	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1288394001403	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1288394001404	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1288394001405	active site
1288394001406	DNA binding site [nucleotide binding]
1288394001407	Int/Topo IB signature motif; other site
1288394001408	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1288394001409	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
1288394001410	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1288394001411	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1288394001412	substrate binding pocket [chemical binding]; other site
1288394001413	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1288394001414	B12 binding site [chemical binding]; other site
1288394001415	cobalt ligand [ion binding]; other site
1288394001416	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1288394001417	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
1288394001418	RimK-like ATP-grasp domain; Region: RimK; pfam08443
1288394001419	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1288394001420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394001421	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394001422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394001423	active site
1288394001424	phosphorylation site [posttranslational modification]
1288394001425	intermolecular recognition site; other site
1288394001426	dimerization interface [polypeptide binding]; other site
1288394001427	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394001428	DNA binding site [nucleotide binding]
1288394001429	Aerolysin toxin; Region: Aerolysin; smart00999
1288394001430	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1288394001431	ThiC-associated domain; Region: ThiC-associated; pfam13667
1288394001432	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1288394001433	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1288394001434	dimer interface [polypeptide binding]; other site
1288394001435	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
1288394001436	substrate binding site [chemical binding]; other site
1288394001437	ATP binding site [chemical binding]; other site
1288394001438	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1288394001439	thiamine phosphate binding site [chemical binding]; other site
1288394001440	active site
1288394001441	pyrophosphate binding site [ion binding]; other site
1288394001442	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1288394001443	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1288394001444	ATP binding site [chemical binding]; other site
1288394001445	substrate interface [chemical binding]; other site
1288394001446	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1288394001447	thiS-thiF/thiG interaction site; other site
1288394001448	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1288394001449	ThiS interaction site; other site
1288394001450	putative active site [active]
1288394001451	tetramer interface [polypeptide binding]; other site
1288394001452	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
1288394001453	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394001454	FeS/SAM binding site; other site
1288394001455	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1288394001456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394001457	ABC transporter signature motif; other site
1288394001458	Walker B; other site
1288394001459	D-loop; other site
1288394001460	H-loop/switch region; other site
1288394001461	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
1288394001462	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394001463	Coenzyme A binding pocket [chemical binding]; other site
1288394001464	PAS fold; Region: PAS_4; pfam08448
1288394001465	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394001466	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394001467	metal binding site [ion binding]; metal-binding site
1288394001468	active site
1288394001469	I-site; other site
1288394001470	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1288394001471	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1288394001472	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
1288394001473	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1288394001474	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394001475	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1288394001476	putative monooxygenase; Provisional; Region: PRK11118
1288394001477	Predicted transcriptional regulators [Transcription]; Region: COG1733
1288394001478	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1288394001479	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394001480	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394001481	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394001482	Coenzyme A binding pocket [chemical binding]; other site
1288394001483	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
1288394001484	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1288394001485	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
1288394001486	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1288394001487	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394001488	N-terminal plug; other site
1288394001489	ligand-binding site [chemical binding]; other site
1288394001490	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
1288394001491	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1288394001492	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1288394001493	trimer interface [polypeptide binding]; other site
1288394001494	eyelet of channel; other site
1288394001495	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1288394001496	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1288394001497	putative active site [active]
1288394001498	Flagellin N-methylase; Region: FliB; cl00497
1288394001499	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
1288394001500	HemY protein N-terminus; Region: HemY_N; pfam07219
1288394001501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1288394001502	binding surface
1288394001503	TPR motif; other site
1288394001504	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
1288394001505	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1288394001506	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1288394001507	active site
1288394001508	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1288394001509	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1288394001510	domain interfaces; other site
1288394001511	active site
1288394001512	adenylate cyclase; Provisional; Region: cyaA; PRK09450
1288394001513	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
1288394001514	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
1288394001515	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
1288394001516	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1288394001517	nucleophilic elbow; other site
1288394001518	catalytic triad; other site
1288394001519	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
1288394001520	putative iron binding site [ion binding]; other site
1288394001521	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1288394001522	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1288394001523	active site
1288394001524	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394001525	substrate binding site [chemical binding]; other site
1288394001526	catalytic residues [active]
1288394001527	dimer interface [polypeptide binding]; other site
1288394001528	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1288394001529	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1288394001530	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1288394001531	Protein of unknown function, DUF484; Region: DUF484; cl17449
1288394001532	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1288394001533	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1288394001534	active site
1288394001535	Int/Topo IB signature motif; other site
1288394001536	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
1288394001537	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394001538	motif II; other site
1288394001539	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1288394001540	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394001541	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1288394001542	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394001543	ligand binding site [chemical binding]; other site
1288394001544	flexible hinge region; other site
1288394001545	Peptidase C26; Region: Peptidase_C26; pfam07722
1288394001546	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1288394001547	catalytic triad [active]
1288394001548	sugar phosphate phosphatase; Provisional; Region: PRK10513
1288394001549	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394001550	active site
1288394001551	motif I; other site
1288394001552	motif II; other site
1288394001553	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394001554	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1288394001555	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1288394001556	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394001557	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1288394001558	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1288394001559	Walker A/P-loop; other site
1288394001560	ATP binding site [chemical binding]; other site
1288394001561	Q-loop/lid; other site
1288394001562	ABC transporter signature motif; other site
1288394001563	Walker B; other site
1288394001564	D-loop; other site
1288394001565	H-loop/switch region; other site
1288394001566	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1288394001567	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1288394001568	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1288394001569	hypothetical protein; Provisional; Region: PRK03673
1288394001570	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1288394001571	putative MPT binding site; other site
1288394001572	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
1288394001573	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1288394001574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394001575	Zn2+ binding site [ion binding]; other site
1288394001576	Mg2+ binding site [ion binding]; other site
1288394001577	homoserine O-succinyltransferase; Provisional; Region: PRK05368
1288394001578	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1288394001579	proposed active site lysine [active]
1288394001580	conserved cys residue [active]
1288394001581	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1288394001582	active site
1288394001583	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1288394001584	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394001585	putative DNA binding site [nucleotide binding]; other site
1288394001586	putative Zn2+ binding site [ion binding]; other site
1288394001587	AsnC family; Region: AsnC_trans_reg; pfam01037
1288394001588	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1288394001589	Sulfatase; Region: Sulfatase; pfam00884
1288394001590	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
1288394001591	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
1288394001592	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394001593	N-terminal plug; other site
1288394001594	ligand-binding site [chemical binding]; other site
1288394001595	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1288394001596	Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551
1288394001597	active site
1288394001598	catalytic site [active]
1288394001599	MgtC family; Region: MgtC; pfam02308
1288394001600	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
1288394001601	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
1288394001602	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1288394001603	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1288394001604	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394001605	Coenzyme A binding pocket [chemical binding]; other site
1288394001606	Protein of unknown function (DUF3624); Region: DUF3624; pfam12292
1288394001607	malonic semialdehyde reductase; Provisional; Region: PRK10538
1288394001608	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1288394001609	putative NAD(P) binding site [chemical binding]; other site
1288394001610	homotetramer interface [polypeptide binding]; other site
1288394001611	homodimer interface [polypeptide binding]; other site
1288394001612	active site
1288394001613	Peptidase family C69; Region: Peptidase_C69; cl17793
1288394001614	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1288394001615	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1288394001616	dimer interface [polypeptide binding]; other site
1288394001617	active site
1288394001618	metal binding site [ion binding]; metal-binding site
1288394001619	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1288394001620	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1288394001621	putative C-terminal domain interface [polypeptide binding]; other site
1288394001622	putative GSH binding site (G-site) [chemical binding]; other site
1288394001623	putative dimer interface [polypeptide binding]; other site
1288394001624	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1288394001625	N-terminal domain interface [polypeptide binding]; other site
1288394001626	dimer interface [polypeptide binding]; other site
1288394001627	substrate binding pocket (H-site) [chemical binding]; other site
1288394001628	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
1288394001629	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1288394001630	homodimer interface [polypeptide binding]; other site
1288394001631	substrate-cofactor binding pocket; other site
1288394001632	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394001633	catalytic residue [active]
1288394001634	transcriptional regulator SgrR; Provisional; Region: PRK13626
1288394001635	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1288394001636	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1288394001637	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1288394001638	active site
1288394001639	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
1288394001640	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1288394001641	Lipase (class 2); Region: Lipase_2; pfam01674
1288394001642	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1288394001643	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1288394001644	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1288394001645	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1288394001646	putative active site [active]
1288394001647	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1288394001648	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1288394001649	putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284
1288394001650	PapC N-terminal domain; Region: PapC_N; pfam13954
1288394001651	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1288394001652	PapC C-terminal domain; Region: PapC_C; pfam13953
1288394001653	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1288394001654	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1288394001655	Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753
1288394001656	Fimbrial protein; Region: Fimbrial; cl01416
1288394001657	Fimbrial protein; Region: Fimbrial; pfam00419
1288394001658	P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539
1288394001659	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394001660	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394001661	DNA binding site [nucleotide binding]
1288394001662	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
1288394001663	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1288394001664	acyl-activating enzyme (AAE) consensus motif; other site
1288394001665	putative AMP binding site [chemical binding]; other site
1288394001666	putative active site [active]
1288394001667	putative CoA binding site [chemical binding]; other site
1288394001668	O-succinylbenzoate synthase; Provisional; Region: PRK05105
1288394001669	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1288394001670	active site
1288394001671	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394001672	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1288394001673	substrate binding site [chemical binding]; other site
1288394001674	oxyanion hole (OAH) forming residues; other site
1288394001675	trimer interface [polypeptide binding]; other site
1288394001676	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1288394001677	Putative serine esterase (DUF676); Region: DUF676; pfam05057
1288394001678	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1288394001679	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1288394001680	dimer interface [polypeptide binding]; other site
1288394001681	tetramer interface [polypeptide binding]; other site
1288394001682	PYR/PP interface [polypeptide binding]; other site
1288394001683	TPP binding site [chemical binding]; other site
1288394001684	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1288394001685	TPP-binding site; other site
1288394001686	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1288394001687	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1288394001688	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1288394001689	UbiA prenyltransferase family; Region: UbiA; pfam01040
1288394001690	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1288394001691	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1288394001692	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1288394001693	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1288394001694	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1288394001695	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1288394001696	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394001697	ATP binding site [chemical binding]; other site
1288394001698	Mg++ binding site [ion binding]; other site
1288394001699	motif III; other site
1288394001700	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394001701	nucleotide binding region [chemical binding]; other site
1288394001702	ATP-binding site [chemical binding]; other site
1288394001703	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
1288394001704	putative RNA binding site [nucleotide binding]; other site
1288394001705	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1288394001706	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1288394001707	Nucleoside recognition; Region: Gate; pfam07670
1288394001708	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1288394001709	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
1288394001710	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1288394001711	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1288394001712	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
1288394001713	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1288394001714	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
1288394001715	Cl binding site [ion binding]; other site
1288394001716	oligomer interface [polypeptide binding]; other site
1288394001717	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1288394001718	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394001719	DNA-J related protein; Region: DNAJ_related; pfam12339
1288394001720	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1288394001721	HSP70 interaction site [polypeptide binding]; other site
1288394001722	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1288394001723	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1288394001724	TrkA-N domain; Region: TrkA_N; pfam02254
1288394001725	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
1288394001726	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
1288394001727	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1288394001728	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1288394001729	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1288394001730	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
1288394001731	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1288394001732	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1288394001733	active site
1288394001734	P-loop; other site
1288394001735	phosphorylation site [posttranslational modification]
1288394001736	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394001737	active site
1288394001738	phosphorylation site [posttranslational modification]
1288394001739	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1288394001740	Protein of unknown function (DUF418); Region: DUF418; cl12135
1288394001741	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394001742	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394001743	exoribonuclease II; Provisional; Region: PRK05054
1288394001744	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1288394001745	RNB domain; Region: RNB; pfam00773
1288394001746	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1288394001747	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394001748	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
1288394001749	putative dimerization interface [polypeptide binding]; other site
1288394001750	Autoinducer synthetase; Region: Autoind_synth; cl17404
1288394001751	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1288394001752	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394001753	DNA binding residues [nucleotide binding]
1288394001754	dimerization interface [polypeptide binding]; other site
1288394001755	L-lysine exporter; Region: 2a75; TIGR00948
1288394001756	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1288394001757	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1288394001758	active site
1288394001759	metal binding site [ion binding]; metal-binding site
1288394001760	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1288394001761	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
1288394001762	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1288394001763	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394001764	Coenzyme A binding pocket [chemical binding]; other site
1288394001765	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
1288394001766	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1288394001767	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1288394001768	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1288394001769	active site
1288394001770	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1288394001771	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394001772	DNA-binding site [nucleotide binding]; DNA binding site
1288394001773	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1288394001774	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1288394001775	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1288394001776	active site
1288394001777	substrate-binding site [chemical binding]; other site
1288394001778	metal-binding site [ion binding]
1288394001779	ATP binding site [chemical binding]; other site
1288394001780	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1288394001781	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1288394001782	dimerization interface [polypeptide binding]; other site
1288394001783	domain crossover interface; other site
1288394001784	redox-dependent activation switch; other site
1288394001785	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394001786	RNA binding surface [nucleotide binding]; other site
1288394001787	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
1288394001788	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1288394001789	type II secretion system protein D; Region: type_II_gspD; TIGR02517
1288394001790	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1288394001791	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1288394001792	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1288394001793	type II secretion system protein E; Region: type_II_gspE; TIGR02533
1288394001794	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1288394001795	Walker A motif; other site
1288394001796	ATP binding site [chemical binding]; other site
1288394001797	Walker B motif; other site
1288394001798	type II secretion system protein F; Region: GspF; TIGR02120
1288394001799	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394001800	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394001801	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1288394001802	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1288394001803	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
1288394001804	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1288394001805	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
1288394001806	Type II transport protein GspH; Region: GspH; pfam12019
1288394001807	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1288394001808	type II secretion system protein I; Region: gspI; TIGR01707
1288394001809	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
1288394001810	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1288394001811	type II secretion system protein J; Region: gspJ; TIGR01711
1288394001812	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
1288394001813	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
1288394001814	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
1288394001815	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
1288394001816	GspL periplasmic domain; Region: GspL_C; pfam12693
1288394001817	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
1288394001818	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
1288394001819	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1288394001820	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394001821	DNA binding residues [nucleotide binding]
1288394001822	dimerization interface [polypeptide binding]; other site
1288394001823	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1288394001824	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1288394001825	active site
1288394001826	HIGH motif; other site
1288394001827	dimer interface [polypeptide binding]; other site
1288394001828	KMSKS motif; other site
1288394001829	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394001830	RNA binding surface [nucleotide binding]; other site
1288394001831	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1288394001832	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394001833	motif II; other site
1288394001834	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1288394001835	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1288394001836	dimer interface [polypeptide binding]; other site
1288394001837	ADP-ribose binding site [chemical binding]; other site
1288394001838	active site
1288394001839	nudix motif; other site
1288394001840	metal binding site [ion binding]; metal-binding site
1288394001841	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1288394001842	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1288394001843	active site
1288394001844	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1288394001845	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1288394001846	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1288394001847	dimer interface [polypeptide binding]; other site
1288394001848	putative tRNA-binding site [nucleotide binding]; other site
1288394001849	Cupin domain; Region: Cupin_2; cl17218
1288394001850	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394001851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394001852	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
1288394001853	dimerization interface [polypeptide binding]; other site
1288394001854	DNA binding site [nucleotide binding]
1288394001855	corepressor binding sites; other site
1288394001856	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
1288394001857	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1288394001858	homodimer interface [polypeptide binding]; other site
1288394001859	substrate-cofactor binding pocket; other site
1288394001860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394001861	catalytic residue [active]
1288394001862	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
1288394001863	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1288394001864	nucleotide binding site [chemical binding]; other site
1288394001865	substrate binding site [chemical binding]; other site
1288394001866	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1288394001867	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1288394001868	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1288394001869	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1288394001870	acetylornithine deacetylase; Provisional; Region: PRK05111
1288394001871	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1288394001872	metal binding site [ion binding]; metal-binding site
1288394001873	putative dimer interface [polypeptide binding]; other site
1288394001874	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1288394001875	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1288394001876	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1288394001877	nucleotide binding site [chemical binding]; other site
1288394001878	substrate binding site [chemical binding]; other site
1288394001879	ornithine carbamoyltransferase; Provisional; Region: PRK14805
1288394001880	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1288394001881	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1288394001882	argininosuccinate synthase; Provisional; Region: PRK13820
1288394001883	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1288394001884	ANP binding site [chemical binding]; other site
1288394001885	Substrate Binding Site II [chemical binding]; other site
1288394001886	Substrate Binding Site I [chemical binding]; other site
1288394001887	argininosuccinate lyase; Provisional; Region: PRK04833
1288394001888	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1288394001889	active sites [active]
1288394001890	tetramer interface [polypeptide binding]; other site
1288394001891	Transcriptional regulator [Transcription]; Region: PaiB; COG2808
1288394001892	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1288394001893	maltose O-acetyltransferase; Provisional; Region: PRK10092
1288394001894	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1288394001895	active site
1288394001896	substrate binding site [chemical binding]; other site
1288394001897	trimer interface [polypeptide binding]; other site
1288394001898	CoA binding site [chemical binding]; other site
1288394001899	Predicted membrane protein [Function unknown]; Region: COG3174
1288394001900	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
1288394001901	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1288394001902	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1288394001903	Serine hydrolase; Region: Ser_hydrolase; pfam06821
1288394001904	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1288394001905	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394001906	dimer interface [polypeptide binding]; other site
1288394001907	conserved gate region; other site
1288394001908	putative PBP binding loops; other site
1288394001909	ABC-ATPase subunit interface; other site
1288394001910	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1288394001911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394001912	dimer interface [polypeptide binding]; other site
1288394001913	conserved gate region; other site
1288394001914	putative PBP binding loops; other site
1288394001915	ABC-ATPase subunit interface; other site
1288394001916	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1288394001917	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1288394001918	Walker A/P-loop; other site
1288394001919	ATP binding site [chemical binding]; other site
1288394001920	Q-loop/lid; other site
1288394001921	ABC transporter signature motif; other site
1288394001922	Walker B; other site
1288394001923	D-loop; other site
1288394001924	H-loop/switch region; other site
1288394001925	TOBE-like domain; Region: TOBE_3; pfam12857
1288394001926	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683
1288394001927	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1288394001928	substrate binding site [chemical binding]; other site
1288394001929	dimerization interface [polypeptide binding]; other site
1288394001930	N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211
1288394001931	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1288394001932	Cache domain; Region: Cache_2; pfam08269
1288394001933	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394001934	dimerization interface [polypeptide binding]; other site
1288394001935	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394001936	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394001937	dimer interface [polypeptide binding]; other site
1288394001938	putative CheW interface [polypeptide binding]; other site
1288394001939	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
1288394001940	active site
1288394001941	Zn binding site [ion binding]; other site
1288394001942	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394001943	substrate binding pocket [chemical binding]; other site
1288394001944	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394001945	membrane-bound complex binding site; other site
1288394001946	hinge residues; other site
1288394001947	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1288394001948	Metallo-peptidase family M84; Region: Peptidase_M84; pfam13688
1288394001949	active site
1288394001950	active site
1288394001951	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1288394001952	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
1288394001953	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1288394001954	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1288394001955	protein binding site [polypeptide binding]; other site
1288394001956	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
1288394001957	Domain interface; other site
1288394001958	Peptide binding site; other site
1288394001959	Active site tetrad [active]
1288394001960	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1288394001961	AzlC protein; Region: AzlC; pfam03591
1288394001962	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1288394001963	hypothetical protein; Provisional; Region: PRK10977
1288394001964	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1288394001965	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1288394001966	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394001967	pyruvate formate lyase II activase; Provisional; Region: PRK10076
1288394001968	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
1288394001969	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394001970	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394001971	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394001972	substrate binding pocket [chemical binding]; other site
1288394001973	dimerization interface [polypeptide binding]; other site
1288394001974	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1288394001975	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394001976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394001977	homodimer interface [polypeptide binding]; other site
1288394001978	catalytic residue [active]
1288394001979	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
1288394001980	putative metal binding site [ion binding]; other site
1288394001981	putative homodimer interface [polypeptide binding]; other site
1288394001982	putative homotetramer interface [polypeptide binding]; other site
1288394001983	putative homodimer-homodimer interface [polypeptide binding]; other site
1288394001984	putative allosteric switch controlling residues; other site
1288394001985	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1288394001986	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1288394001987	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1288394001988	carbohydrate binding site [chemical binding]; other site
1288394001989	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
1288394001990	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1288394001991	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1288394001992	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1288394001993	active site
1288394001994	catalytic site [active]
1288394001995	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
1288394001996	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
1288394001997	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1288394001998	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
1288394001999	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1288394002000	metal-binding site [ion binding]
1288394002001	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1288394002002	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1288394002003	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1288394002004	dimer interface [polypeptide binding]; other site
1288394002005	catalytic triad [active]
1288394002006	peroxidatic and resolving cysteines [active]
1288394002007	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394002008	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1288394002009	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1288394002010	ATP binding site [chemical binding]; other site
1288394002011	putative Mg++ binding site [ion binding]; other site
1288394002012	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394002013	nucleotide binding region [chemical binding]; other site
1288394002014	ATP-binding site [chemical binding]; other site
1288394002015	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1288394002016	putative active site [active]
1288394002017	putative metal binding site [ion binding]; other site
1288394002018	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1288394002019	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
1288394002020	putative catalytic site [active]
1288394002021	metal binding site A [ion binding]; metal-binding site
1288394002022	phosphate binding site [ion binding]; other site
1288394002023	metal binding site C [ion binding]; metal-binding site
1288394002024	metal binding site B [ion binding]; metal-binding site
1288394002025	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394002026	PAS domain; Region: PAS_9; pfam13426
1288394002027	putative active site [active]
1288394002028	heme pocket [chemical binding]; other site
1288394002029	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394002030	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394002031	dimer interface [polypeptide binding]; other site
1288394002032	putative CheW interface [polypeptide binding]; other site
1288394002033	CAAX protease self-immunity; Region: Abi; pfam02517
1288394002034	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
1288394002035	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1288394002036	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1288394002037	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1288394002038	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1288394002039	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1288394002040	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1288394002041	NnrU protein; Region: NnrU; pfam07298
1288394002042	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1288394002043	catalytic residues [active]
1288394002044	dimer interface [polypeptide binding]; other site
1288394002045	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394002046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002047	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394002048	putative effector binding pocket; other site
1288394002049	dimerization interface [polypeptide binding]; other site
1288394002050	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1288394002051	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1288394002052	Nucleoside recognition; Region: Gate; pfam07670
1288394002053	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1288394002054	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1288394002055	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1288394002056	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1288394002057	DNA binding site [nucleotide binding]
1288394002058	active site
1288394002059	hypothetical protein; Provisional; Region: PRK09256
1288394002060	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1288394002061	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1288394002062	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1288394002063	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1288394002064	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1288394002065	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1288394002066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002067	dimer interface [polypeptide binding]; other site
1288394002068	conserved gate region; other site
1288394002069	putative PBP binding loops; other site
1288394002070	ABC-ATPase subunit interface; other site
1288394002071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002072	dimer interface [polypeptide binding]; other site
1288394002073	conserved gate region; other site
1288394002074	putative PBP binding loops; other site
1288394002075	ABC-ATPase subunit interface; other site
1288394002076	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1288394002077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394002078	Walker A/P-loop; other site
1288394002079	ATP binding site [chemical binding]; other site
1288394002080	Q-loop/lid; other site
1288394002081	ABC transporter signature motif; other site
1288394002082	Walker B; other site
1288394002083	D-loop; other site
1288394002084	H-loop/switch region; other site
1288394002085	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1288394002086	arginine repressor; Provisional; Region: PRK05066
1288394002087	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1288394002088	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1288394002089	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
1288394002090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394002091	Walker A/P-loop; other site
1288394002092	ATP binding site [chemical binding]; other site
1288394002093	Q-loop/lid; other site
1288394002094	ABC transporter signature motif; other site
1288394002095	Walker B; other site
1288394002096	D-loop; other site
1288394002097	H-loop/switch region; other site
1288394002098	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
1288394002099	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394002100	substrate binding pocket [chemical binding]; other site
1288394002101	membrane-bound complex binding site; other site
1288394002102	hinge residues; other site
1288394002103	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394002104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002105	dimer interface [polypeptide binding]; other site
1288394002106	conserved gate region; other site
1288394002107	putative PBP binding loops; other site
1288394002108	ABC-ATPase subunit interface; other site
1288394002109	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394002110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002111	dimer interface [polypeptide binding]; other site
1288394002112	conserved gate region; other site
1288394002113	putative PBP binding loops; other site
1288394002114	ABC-ATPase subunit interface; other site
1288394002115	malate dehydrogenase; Provisional; Region: PRK05086
1288394002116	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
1288394002117	NAD binding site [chemical binding]; other site
1288394002118	dimerization interface [polypeptide binding]; other site
1288394002119	Substrate binding site [chemical binding]; other site
1288394002120	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1288394002121	Sel1 repeat; Region: Sel1; cl02723
1288394002122	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1288394002123	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1288394002124	heme-binding site [chemical binding]; other site
1288394002125	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1288394002126	FAD binding pocket [chemical binding]; other site
1288394002127	FAD binding motif [chemical binding]; other site
1288394002128	phosphate binding motif [ion binding]; other site
1288394002129	beta-alpha-beta structure motif; other site
1288394002130	NAD binding pocket [chemical binding]; other site
1288394002131	Heme binding  pocket [chemical binding]; other site
1288394002132	Transcriptional regulator; Region: Rrf2; cl17282
1288394002133	Rrf2 family protein; Region: rrf2_super; TIGR00738
1288394002134	hypothetical protein; Provisional; Region: PRK11573
1288394002135	Domain of unknown function DUF21; Region: DUF21; pfam01595
1288394002136	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1288394002137	Transporter associated domain; Region: CorC_HlyC; smart01091
1288394002138	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
1288394002139	signal recognition particle protein; Provisional; Region: PRK10867
1288394002140	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1288394002141	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1288394002142	P loop; other site
1288394002143	GTP binding site [chemical binding]; other site
1288394002144	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1288394002145	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1288394002146	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1288394002147	RimM N-terminal domain; Region: RimM; pfam01782
1288394002148	PRC-barrel domain; Region: PRC; pfam05239
1288394002149	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1288394002150	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1288394002151	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
1288394002152	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
1288394002153	putative DNA-binding cleft [nucleotide binding]; other site
1288394002154	putative DNA clevage site; other site
1288394002155	molecular lever; other site
1288394002156	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1288394002157	putative active site [active]
1288394002158	Ap4A binding site [chemical binding]; other site
1288394002159	nudix motif; other site
1288394002160	putative metal binding site [ion binding]; other site
1288394002161	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
1288394002162	GAF domain; Region: GAF; pfam01590
1288394002163	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1288394002164	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1288394002165	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1288394002166	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1288394002167	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1288394002168	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1288394002169	dimerization interface [polypeptide binding]; other site
1288394002170	active site
1288394002171	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
1288394002172	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
1288394002173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002174	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
1288394002175	putative dimerization interface [polypeptide binding]; other site
1288394002176	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394002177	dimerization interface [polypeptide binding]; other site
1288394002178	putative DNA binding site [nucleotide binding]; other site
1288394002179	putative Zn2+ binding site [ion binding]; other site
1288394002180	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1288394002181	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1288394002182	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1288394002183	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1288394002184	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1288394002185	active site
1288394002186	Riboflavin kinase; Region: Flavokinase; smart00904
1288394002187	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1288394002188	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1288394002189	active site
1288394002190	HIGH motif; other site
1288394002191	nucleotide binding site [chemical binding]; other site
1288394002192	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1288394002193	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1288394002194	active site
1288394002195	KMSKS motif; other site
1288394002196	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1288394002197	tRNA binding surface [nucleotide binding]; other site
1288394002198	anticodon binding site; other site
1288394002199	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1288394002200	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1288394002201	lipoprotein signal peptidase; Provisional; Region: PRK14787
1288394002202	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1288394002203	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1288394002204	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1288394002205	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1288394002206	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1288394002207	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
1288394002208	Type II transport protein GspH; Region: GspH; pfam12019
1288394002209	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
1288394002210	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1288394002211	TraA; Region: TraA; cl11503
1288394002212	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
1288394002213	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
1288394002214	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1288394002215	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
1288394002216	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
1288394002217	hypothetical protein; Provisional; Region: PRK10506
1288394002218	hypothetical protein; Provisional; Region: PRK10557
1288394002219	NAD synthetase; Provisional; Region: PRK13981
1288394002220	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1288394002221	multimer interface [polypeptide binding]; other site
1288394002222	active site
1288394002223	catalytic triad [active]
1288394002224	protein interface 1 [polypeptide binding]; other site
1288394002225	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1288394002226	homodimer interface [polypeptide binding]; other site
1288394002227	NAD binding pocket [chemical binding]; other site
1288394002228	ATP binding pocket [chemical binding]; other site
1288394002229	Mg binding site [ion binding]; other site
1288394002230	active-site loop [active]
1288394002231	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1288394002232	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1288394002233	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394002234	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394002235	catalytic residue [active]
1288394002236	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1288394002237	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394002238	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394002239	metal binding site [ion binding]; metal-binding site
1288394002240	active site
1288394002241	I-site; other site
1288394002242	exoribonuclease R; Provisional; Region: PRK11642
1288394002243	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1288394002244	RNB domain; Region: RNB; pfam00773
1288394002245	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1288394002246	RNA binding site [nucleotide binding]; other site
1288394002247	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
1288394002248	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1288394002249	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1288394002250	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1288394002251	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394002252	ligand binding site [chemical binding]; other site
1288394002253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394002254	Coenzyme A binding pocket [chemical binding]; other site
1288394002255	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394002256	EamA-like transporter family; Region: EamA; pfam00892
1288394002257	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1288394002258	alanine-tRNA ligase; Region: PLN02961
1288394002259	manganese transport protein MntH; Reviewed; Region: PRK00701
1288394002260	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1288394002261	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1288394002262	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1288394002263	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1288394002264	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1288394002265	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1288394002266	ferredoxin-NADP reductase; Provisional; Region: PRK10926
1288394002267	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1288394002268	FAD binding pocket [chemical binding]; other site
1288394002269	FAD binding motif [chemical binding]; other site
1288394002270	phosphate binding motif [ion binding]; other site
1288394002271	beta-alpha-beta structure motif; other site
1288394002272	NAD binding pocket [chemical binding]; other site
1288394002273	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1288394002274	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1288394002275	putative NAD(P) binding site [chemical binding]; other site
1288394002276	Predicted membrane protein [Function unknown]; Region: COG1238
1288394002277	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1288394002278	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1288394002279	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1288394002280	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1288394002281	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1288394002282	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1288394002283	glutamate--cysteine ligase; Provisional; Region: PRK02107
1288394002284	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
1288394002285	active site
1288394002286	catalytic residues [active]
1288394002287	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1288394002288	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1288394002289	acyl-activating enzyme (AAE) consensus motif; other site
1288394002290	putative AMP binding site [chemical binding]; other site
1288394002291	putative active site [active]
1288394002292	putative CoA binding site [chemical binding]; other site
1288394002293	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1288394002294	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394002295	Coenzyme A binding pocket [chemical binding]; other site
1288394002296	DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436
1288394002297	regulatory ATPase RavA; Provisional; Region: PRK13531
1288394002298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394002299	Walker A motif; other site
1288394002300	ATP binding site [chemical binding]; other site
1288394002301	Walker B motif; other site
1288394002302	arginine finger; other site
1288394002303	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
1288394002304	hypothetical protein; Provisional; Region: yieM; PRK10997
1288394002305	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
1288394002306	metal ion-dependent adhesion site (MIDAS); other site
1288394002307	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394002308	PAS fold; Region: PAS_3; pfam08447
1288394002309	putative active site [active]
1288394002310	heme pocket [chemical binding]; other site
1288394002311	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394002312	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394002313	metal binding site [ion binding]; metal-binding site
1288394002314	active site
1288394002315	I-site; other site
1288394002316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1288394002317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394002318	binding surface
1288394002319	TPR motif; other site
1288394002320	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1288394002321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1288394002322	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394002323	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394002324	metal binding site [ion binding]; metal-binding site
1288394002325	active site
1288394002326	I-site; other site
1288394002327	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1288394002328	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1288394002329	G1 box; other site
1288394002330	putative GEF interaction site [polypeptide binding]; other site
1288394002331	GTP/Mg2+ binding site [chemical binding]; other site
1288394002332	Switch I region; other site
1288394002333	G2 box; other site
1288394002334	G3 box; other site
1288394002335	Switch II region; other site
1288394002336	G4 box; other site
1288394002337	G5 box; other site
1288394002338	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1288394002339	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1288394002340	MarR family; Region: MarR_2; pfam12802
1288394002341	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1288394002342	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1288394002343	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1288394002344	MarR family; Region: MarR; pfam01047
1288394002345	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1288394002346	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1288394002347	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1288394002348	FMN binding site [chemical binding]; other site
1288394002349	active site
1288394002350	substrate binding site [chemical binding]; other site
1288394002351	catalytic residue [active]
1288394002352	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394002353	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394002354	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394002355	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002356	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394002357	substrate binding pocket [chemical binding]; other site
1288394002358	dimerization interface [polypeptide binding]; other site
1288394002359	agmatine deiminase; Provisional; Region: PRK13551
1288394002360	agmatine deiminase; Region: agmatine_aguA; TIGR03380
1288394002361	amidase; Validated; Region: PRK06565
1288394002362	Amidase; Region: Amidase; cl11426
1288394002363	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1288394002364	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1288394002365	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
1288394002366	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1288394002367	helicase 45; Provisional; Region: PTZ00424
1288394002368	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394002369	ATP binding site [chemical binding]; other site
1288394002370	Mg++ binding site [ion binding]; other site
1288394002371	motif III; other site
1288394002372	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394002373	nucleotide binding region [chemical binding]; other site
1288394002374	ATP-binding site [chemical binding]; other site
1288394002375	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394002376	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002377	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394002378	dimerization interface [polypeptide binding]; other site
1288394002379	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1288394002380	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1288394002381	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1288394002382	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1288394002383	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
1288394002384	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1288394002385	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
1288394002386	trimer interface [polypeptide binding]; other site
1288394002387	active site
1288394002388	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
1288394002389	CAS motifs; other site
1288394002390	active site
1288394002391	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1288394002392	Nitronate monooxygenase; Region: NMO; pfam03060
1288394002393	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1288394002394	FMN binding site [chemical binding]; other site
1288394002395	substrate binding site [chemical binding]; other site
1288394002396	putative catalytic residue [active]
1288394002397	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1288394002398	nudix motif; other site
1288394002399	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394002400	dimerization interface [polypeptide binding]; other site
1288394002401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394002402	dimer interface [polypeptide binding]; other site
1288394002403	phosphorylation site [posttranslational modification]
1288394002404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394002405	ATP binding site [chemical binding]; other site
1288394002406	Mg2+ binding site [ion binding]; other site
1288394002407	G-X-G motif; other site
1288394002408	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394002409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394002410	active site
1288394002411	phosphorylation site [posttranslational modification]
1288394002412	intermolecular recognition site; other site
1288394002413	dimerization interface [polypeptide binding]; other site
1288394002414	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394002415	DNA binding site [nucleotide binding]
1288394002416	HlyD family secretion protein; Region: HlyD_2; pfam12700
1288394002417	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394002418	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394002419	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1288394002420	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1288394002421	Walker A/P-loop; other site
1288394002422	ATP binding site [chemical binding]; other site
1288394002423	Q-loop/lid; other site
1288394002424	ABC transporter signature motif; other site
1288394002425	Walker B; other site
1288394002426	D-loop; other site
1288394002427	H-loop/switch region; other site
1288394002428	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1288394002429	FtsX-like permease family; Region: FtsX; pfam02687
1288394002430	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1288394002431	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394002432	substrate binding pocket [chemical binding]; other site
1288394002433	membrane-bound complex binding site; other site
1288394002434	hinge residues; other site
1288394002435	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1288394002436	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1288394002437	Walker A/P-loop; other site
1288394002438	ATP binding site [chemical binding]; other site
1288394002439	Q-loop/lid; other site
1288394002440	ABC transporter signature motif; other site
1288394002441	Walker B; other site
1288394002442	D-loop; other site
1288394002443	H-loop/switch region; other site
1288394002444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002445	dimer interface [polypeptide binding]; other site
1288394002446	conserved gate region; other site
1288394002447	putative PBP binding loops; other site
1288394002448	ABC-ATPase subunit interface; other site
1288394002449	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394002450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002451	dimer interface [polypeptide binding]; other site
1288394002452	conserved gate region; other site
1288394002453	putative PBP binding loops; other site
1288394002454	ABC-ATPase subunit interface; other site
1288394002455	threonine synthase; Validated; Region: PRK08197
1288394002456	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1288394002457	homodimer interface [polypeptide binding]; other site
1288394002458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394002459	catalytic residue [active]
1288394002460	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1288394002461	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1288394002462	AsmA family; Region: AsmA; pfam05170
1288394002463	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1288394002464	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1288394002465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394002466	Coenzyme A binding pocket [chemical binding]; other site
1288394002467	Uncharacterized conserved protein [Function unknown]; Region: COG4748
1288394002468	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1288394002469	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
1288394002470	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1288394002471	metal binding triad; other site
1288394002472	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1288394002473	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1288394002474	metal binding triad; other site
1288394002475	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1288394002476	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394002477	Coenzyme A binding pocket [chemical binding]; other site
1288394002478	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394002479	HAMP domain; Region: HAMP; pfam00672
1288394002480	dimerization interface [polypeptide binding]; other site
1288394002481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394002482	dimer interface [polypeptide binding]; other site
1288394002483	putative CheW interface [polypeptide binding]; other site
1288394002484	Ion channel; Region: Ion_trans_2; pfam07885
1288394002485	SH3 domain-containing protein; Provisional; Region: PRK10884
1288394002486	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1288394002487	SlyX; Region: SlyX; cl01090
1288394002488	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
1288394002489	Proline dehydrogenase; Region: Pro_dh; pfam01619
1288394002490	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1288394002491	Glutamate binding site [chemical binding]; other site
1288394002492	NAD binding site [chemical binding]; other site
1288394002493	catalytic residues [active]
1288394002494	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1288394002495	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1288394002496	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1288394002497	putative NADH binding site [chemical binding]; other site
1288394002498	putative active site [active]
1288394002499	nudix motif; other site
1288394002500	putative metal binding site [ion binding]; other site
1288394002501	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1288394002502	substrate binding site [chemical binding]; other site
1288394002503	active site
1288394002504	fructokinase; Reviewed; Region: PRK09557
1288394002505	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1288394002506	nucleotide binding site [chemical binding]; other site
1288394002507	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
1288394002508	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1288394002509	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1288394002510	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1288394002511	Phosphoglycerate kinase; Region: PGK; pfam00162
1288394002512	substrate binding site [chemical binding]; other site
1288394002513	hinge regions; other site
1288394002514	ADP binding site [chemical binding]; other site
1288394002515	catalytic site [active]
1288394002516	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1288394002517	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
1288394002518	active site
1288394002519	intersubunit interface [polypeptide binding]; other site
1288394002520	zinc binding site [ion binding]; other site
1288394002521	Na+ binding site [ion binding]; other site
1288394002522	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1288394002523	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1288394002524	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1288394002525	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
1288394002526	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1288394002527	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1288394002528	DsbD alpha interface [polypeptide binding]; other site
1288394002529	catalytic residues [active]
1288394002530	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
1288394002531	Predicted membrane protein [Function unknown]; Region: COG4125
1288394002532	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1288394002533	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
1288394002534	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394002535	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002536	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394002537	dimerization interface [polypeptide binding]; other site
1288394002538	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1288394002539	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1288394002540	Uncharacterized conserved protein [Function unknown]; Region: COG2938
1288394002541	L-aspartate oxidase; Provisional; Region: PRK09077
1288394002542	L-aspartate oxidase; Provisional; Region: PRK06175
1288394002543	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1288394002544	RNA polymerase sigma factor AlgU; Provisional; Region: algU; PRK11923
1288394002545	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394002546	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394002547	DNA binding residues [nucleotide binding]
1288394002548	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1288394002549	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
1288394002550	anti-sigma E factor; Provisional; Region: rseB; PRK09455
1288394002551	MucB/RseB family; Region: MucB_RseB; pfam03888
1288394002552	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
1288394002553	GTP-binding protein LepA; Provisional; Region: PRK05433
1288394002554	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1288394002555	G1 box; other site
1288394002556	putative GEF interaction site [polypeptide binding]; other site
1288394002557	GTP/Mg2+ binding site [chemical binding]; other site
1288394002558	Switch I region; other site
1288394002559	G2 box; other site
1288394002560	G3 box; other site
1288394002561	Switch II region; other site
1288394002562	G4 box; other site
1288394002563	G5 box; other site
1288394002564	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1288394002565	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1288394002566	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1288394002567	signal peptidase I; Provisional; Region: PRK10861
1288394002568	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1288394002569	Catalytic site [active]
1288394002570	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1288394002571	ribonuclease III; Reviewed; Region: rnc; PRK00102
1288394002572	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1288394002573	dimerization interface [polypeptide binding]; other site
1288394002574	active site
1288394002575	metal binding site [ion binding]; metal-binding site
1288394002576	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1288394002577	dsRNA binding site [nucleotide binding]; other site
1288394002578	GTPase Era; Reviewed; Region: era; PRK00089
1288394002579	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1288394002580	G1 box; other site
1288394002581	GTP/Mg2+ binding site [chemical binding]; other site
1288394002582	Switch I region; other site
1288394002583	G2 box; other site
1288394002584	Switch II region; other site
1288394002585	G3 box; other site
1288394002586	G4 box; other site
1288394002587	G5 box; other site
1288394002588	KH domain; Region: KH_2; pfam07650
1288394002589	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1288394002590	Recombination protein O N terminal; Region: RecO_N; pfam11967
1288394002591	Recombination protein O C terminal; Region: RecO_C; pfam02565
1288394002592	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1288394002593	active site
1288394002594	hydrophilic channel; other site
1288394002595	dimerization interface [polypeptide binding]; other site
1288394002596	catalytic residues [active]
1288394002597	active site lid [active]
1288394002598	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
1288394002599	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1288394002600	intersubunit interface [polypeptide binding]; other site
1288394002601	active site
1288394002602	zinc binding site [ion binding]; other site
1288394002603	Na+ binding site [ion binding]; other site
1288394002604	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1288394002605	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1288394002606	active site
1288394002607	dimer interface [polypeptide binding]; other site
1288394002608	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1288394002609	active pocket/dimerization site; other site
1288394002610	active site
1288394002611	phosphorylation site [posttranslational modification]
1288394002612	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1288394002613	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1288394002614	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1288394002615	active site
1288394002616	phosphorylation site [posttranslational modification]
1288394002617	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
1288394002618	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1288394002619	dimer interface [polypeptide binding]; other site
1288394002620	active site
1288394002621	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
1288394002622	putative active site [active]
1288394002623	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
1288394002624	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
1288394002625	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1288394002626	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1288394002627	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1288394002628	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1288394002629	amidase catalytic site [active]
1288394002630	Zn binding residues [ion binding]; other site
1288394002631	substrate binding site [chemical binding]; other site
1288394002632	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1288394002633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
1288394002634	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1288394002635	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
1288394002636	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
1288394002637	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
1288394002638	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394002639	dimerization interface [polypeptide binding]; other site
1288394002640	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394002641	dimer interface [polypeptide binding]; other site
1288394002642	phosphorylation site [posttranslational modification]
1288394002643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394002644	ATP binding site [chemical binding]; other site
1288394002645	Mg2+ binding site [ion binding]; other site
1288394002646	G-X-G motif; other site
1288394002647	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
1288394002648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394002649	active site
1288394002650	phosphorylation site [posttranslational modification]
1288394002651	intermolecular recognition site; other site
1288394002652	dimerization interface [polypeptide binding]; other site
1288394002653	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
1288394002654	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
1288394002655	TRAM domain; Region: TRAM; pfam01938
1288394002656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394002657	S-adenosylmethionine binding site [chemical binding]; other site
1288394002658	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
1288394002659	HD domain; Region: HD_4; pfam13328
1288394002660	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1288394002661	synthetase active site [active]
1288394002662	NTP binding site [chemical binding]; other site
1288394002663	metal binding site [ion binding]; metal-binding site
1288394002664	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1288394002665	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1288394002666	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1288394002667	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1288394002668	homodimer interface [polypeptide binding]; other site
1288394002669	metal binding site [ion binding]; metal-binding site
1288394002670	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1288394002671	homodimer interface [polypeptide binding]; other site
1288394002672	active site
1288394002673	putative chemical substrate binding site [chemical binding]; other site
1288394002674	metal binding site [ion binding]; metal-binding site
1288394002675	CTP synthetase; Validated; Region: pyrG; PRK05380
1288394002676	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1288394002677	Catalytic site [active]
1288394002678	active site
1288394002679	UTP binding site [chemical binding]; other site
1288394002680	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1288394002681	active site
1288394002682	putative oxyanion hole; other site
1288394002683	catalytic triad [active]
1288394002684	enolase; Provisional; Region: eno; PRK00077
1288394002685	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1288394002686	dimer interface [polypeptide binding]; other site
1288394002687	metal binding site [ion binding]; metal-binding site
1288394002688	substrate binding pocket [chemical binding]; other site
1288394002689	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1288394002690	Septum formation initiator; Region: DivIC; cl17659
1288394002691	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1288394002692	substrate binding site; other site
1288394002693	dimer interface; other site
1288394002694	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1288394002695	homotrimer interaction site [polypeptide binding]; other site
1288394002696	zinc binding site [ion binding]; other site
1288394002697	CDP-binding sites; other site
1288394002698	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
1288394002699	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
1288394002700	Permutation of conserved domain; other site
1288394002701	active site
1288394002702	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1288394002703	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1288394002704	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1288394002705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394002706	S-adenosylmethionine binding site [chemical binding]; other site
1288394002707	Predicted membrane protein [Function unknown]; Region: COG1238
1288394002708	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
1288394002709	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394002710	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394002711	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394002712	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
1288394002713	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1288394002714	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394002715	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1288394002716	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394002717	DNA binding residues [nucleotide binding]
1288394002718	UGMP family protein; Validated; Region: PRK09604
1288394002719	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1288394002720	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1288394002721	Yqey-like protein; Region: YqeY; pfam09424
1288394002722	DNA primase; Validated; Region: dnaG; PRK05667
1288394002723	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1288394002724	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1288394002725	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1288394002726	active site
1288394002727	metal binding site [ion binding]; metal-binding site
1288394002728	interdomain interaction site; other site
1288394002729	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1288394002730	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
1288394002731	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1288394002732	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1288394002733	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1288394002734	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1288394002735	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394002736	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1288394002737	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394002738	DNA binding residues [nucleotide binding]
1288394002739	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
1288394002740	Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317
1288394002741	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1288394002742	active site
1288394002743	Ca binding site [ion binding]; other site
1288394002744	catalytic site [active]
1288394002745	Aamy_C domain; Region: Aamy_C; smart00632
1288394002746	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cd12956
1288394002747	starch binding site [chemical binding]; other site
1288394002748	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
1288394002749	starch binding site [chemical binding]; other site
1288394002750	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
1288394002751	starch binding site [chemical binding]; other site
1288394002752	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1288394002753	Cytochrome b562; Region: Cytochrom_B562; cl01546
1288394002754	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1288394002755	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1288394002756	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1288394002757	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1288394002758	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1288394002759	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1288394002760	purine monophosphate binding site [chemical binding]; other site
1288394002761	dimer interface [polypeptide binding]; other site
1288394002762	putative catalytic residues [active]
1288394002763	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1288394002764	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1288394002765	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
1288394002766	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1288394002767	DNA binding residues [nucleotide binding]
1288394002768	dimer interface [polypeptide binding]; other site
1288394002769	metal binding site [ion binding]; metal-binding site
1288394002770	RibD C-terminal domain; Region: RibD_C; cl17279
1288394002771	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1288394002772	Domain of unknown function; Region: DUF331; pfam03889
1288394002773	HemN family oxidoreductase; Provisional; Region: PRK05660
1288394002774	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394002775	FeS/SAM binding site; other site
1288394002776	HemN C-terminal domain; Region: HemN_C; pfam06969
1288394002777	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1288394002778	active site
1288394002779	dimerization interface [polypeptide binding]; other site
1288394002780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394002781	putative substrate translocation pore; other site
1288394002782	putative oxidoreductase; Provisional; Region: PRK11579
1288394002783	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1288394002784	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1288394002785	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394002786	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394002787	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394002788	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1288394002789	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1288394002790	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1288394002791	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1288394002792	active site
1288394002793	Zn binding site [ion binding]; other site
1288394002794	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1288394002795	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394002796	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002797	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394002798	dimerization interface [polypeptide binding]; other site
1288394002799	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1288394002800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394002801	putative substrate translocation pore; other site
1288394002802	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1288394002803	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1288394002804	trimer interface [polypeptide binding]; other site
1288394002805	eyelet of channel; other site
1288394002806	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1288394002807	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
1288394002808	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1288394002809	Aspartase; Region: Aspartase; cd01357
1288394002810	active sites [active]
1288394002811	tetramer interface [polypeptide binding]; other site
1288394002812	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
1288394002813	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1288394002814	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
1288394002815	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1288394002816	oligomerisation interface [polypeptide binding]; other site
1288394002817	mobile loop; other site
1288394002818	roof hairpin; other site
1288394002819	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1288394002820	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1288394002821	ring oligomerisation interface [polypeptide binding]; other site
1288394002822	ATP/Mg binding site [chemical binding]; other site
1288394002823	stacking interactions; other site
1288394002824	hinge regions; other site
1288394002825	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1288394002826	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394002827	metal binding site [ion binding]; metal-binding site
1288394002828	active site
1288394002829	I-site; other site
1288394002830	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394002831	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
1288394002832	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
1288394002833	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1288394002834	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1288394002835	active site
1288394002836	ATP-dependent helicase HepA; Validated; Region: PRK04914
1288394002837	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394002838	ATP binding site [chemical binding]; other site
1288394002839	putative Mg++ binding site [ion binding]; other site
1288394002840	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394002841	nucleotide binding region [chemical binding]; other site
1288394002842	ATP-binding site [chemical binding]; other site
1288394002843	Early set domain associated with the catalytic domain of pullulanase-like proteins; Region: E_set_pullulanase_like; cd02861
1288394002844	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1288394002845	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1288394002846	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1288394002847	active site
1288394002848	dimer interface [polypeptide binding]; other site
1288394002849	effector binding site; other site
1288394002850	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1288394002851	TSCPD domain; Region: TSCPD; pfam12637
1288394002852	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1288394002853	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1288394002854	putative active site [active]
1288394002855	PhoH-like protein; Region: PhoH; pfam02562
1288394002856	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1288394002857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394002858	Walker A/P-loop; other site
1288394002859	ATP binding site [chemical binding]; other site
1288394002860	Q-loop/lid; other site
1288394002861	ABC transporter signature motif; other site
1288394002862	Walker B; other site
1288394002863	D-loop; other site
1288394002864	H-loop/switch region; other site
1288394002865	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1288394002866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002867	dimer interface [polypeptide binding]; other site
1288394002868	ABC-ATPase subunit interface; other site
1288394002869	putative PBP binding loops; other site
1288394002870	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394002871	dimer interface [polypeptide binding]; other site
1288394002872	conserved gate region; other site
1288394002873	putative PBP binding loops; other site
1288394002874	ABC-ATPase subunit interface; other site
1288394002875	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1288394002876	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1288394002877	PilZ domain; Region: PilZ; pfam07238
1288394002878	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
1288394002879	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1288394002880	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1288394002881	substrate binding site [chemical binding]; other site
1288394002882	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1288394002883	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1288394002884	substrate binding site [chemical binding]; other site
1288394002885	ligand binding site [chemical binding]; other site
1288394002886	tartrate dehydrogenase; Region: TTC; TIGR02089
1288394002887	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1288394002888	2-isopropylmalate synthase; Validated; Region: PRK00915
1288394002889	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1288394002890	active site
1288394002891	catalytic residues [active]
1288394002892	metal binding site [ion binding]; metal-binding site
1288394002893	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1288394002894	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394002895	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394002896	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1288394002897	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1288394002898	active site
1288394002899	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
1288394002900	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394002901	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979
1288394002902	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1288394002903	PYR/PP interface [polypeptide binding]; other site
1288394002904	dimer interface [polypeptide binding]; other site
1288394002905	TPP binding site [chemical binding]; other site
1288394002906	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1288394002907	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1288394002908	TPP-binding site [chemical binding]; other site
1288394002909	dimer interface [polypeptide binding]; other site
1288394002910	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1288394002911	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1288394002912	putative valine binding site [chemical binding]; other site
1288394002913	dimer interface [polypeptide binding]; other site
1288394002914	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1288394002915	phosphate acetyltransferase; Reviewed; Region: PRK05632
1288394002916	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1288394002917	DRTGG domain; Region: DRTGG; pfam07085
1288394002918	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1288394002919	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1288394002920	propionate/acetate kinase; Provisional; Region: PRK12379
1288394002921	Protein of unknown function, DUF412; Region: DUF412; pfam04217
1288394002922	hypothetical protein; Validated; Region: PRK05445
1288394002923	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1288394002924	catalytic triad [active]
1288394002925	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
1288394002926	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
1288394002927	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1288394002928	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1288394002929	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1288394002930	dimer interface [polypeptide binding]; other site
1288394002931	active site
1288394002932	catalytic residue [active]
1288394002933	lipoprotein; Provisional; Region: PRK11679
1288394002934	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
1288394002935	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1288394002936	ATP binding site [chemical binding]; other site
1288394002937	active site
1288394002938	substrate binding site [chemical binding]; other site
1288394002939	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1288394002940	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1288394002941	putative NAD(P) binding site [chemical binding]; other site
1288394002942	homodimer interface [polypeptide binding]; other site
1288394002943	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394002944	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394002945	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394002946	putative effector binding pocket; other site
1288394002947	dimerization interface [polypeptide binding]; other site
1288394002948	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
1288394002949	HIT domain; Region: HIT; pfam01230
1288394002950	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
1288394002951	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
1288394002952	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
1288394002953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394002954	putative active site [active]
1288394002955	heme pocket [chemical binding]; other site
1288394002956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394002957	dimer interface [polypeptide binding]; other site
1288394002958	phosphorylation site [posttranslational modification]
1288394002959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394002960	ATP binding site [chemical binding]; other site
1288394002961	Mg2+ binding site [ion binding]; other site
1288394002962	G-X-G motif; other site
1288394002963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394002964	active site
1288394002965	phosphorylation site [posttranslational modification]
1288394002966	intermolecular recognition site; other site
1288394002967	dimerization interface [polypeptide binding]; other site
1288394002968	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
1288394002969	putative binding surface; other site
1288394002970	active site
1288394002971	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
1288394002972	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394002973	Zn2+ binding site [ion binding]; other site
1288394002974	Mg2+ binding site [ion binding]; other site
1288394002975	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1288394002976	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394002977	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394002978	substrate binding pocket [chemical binding]; other site
1288394002979	membrane-bound complex binding site; other site
1288394002980	hinge residues; other site
1288394002981	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394002982	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394002983	substrate binding pocket [chemical binding]; other site
1288394002984	membrane-bound complex binding site; other site
1288394002985	hinge residues; other site
1288394002986	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1288394002987	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394002988	putative active site [active]
1288394002989	heme pocket [chemical binding]; other site
1288394002990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394002991	dimer interface [polypeptide binding]; other site
1288394002992	phosphorylation site [posttranslational modification]
1288394002993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394002994	ATP binding site [chemical binding]; other site
1288394002995	Mg2+ binding site [ion binding]; other site
1288394002996	G-X-G motif; other site
1288394002997	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394002998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394002999	active site
1288394003000	phosphorylation site [posttranslational modification]
1288394003001	intermolecular recognition site; other site
1288394003002	dimerization interface [polypeptide binding]; other site
1288394003003	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1288394003004	putative binding surface; other site
1288394003005	active site
1288394003006	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394003007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394003008	active site
1288394003009	phosphorylation site [posttranslational modification]
1288394003010	intermolecular recognition site; other site
1288394003011	dimerization interface [polypeptide binding]; other site
1288394003012	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394003013	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394003014	CHASE3 domain; Region: CHASE3; cl05000
1288394003015	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394003016	dimerization interface [polypeptide binding]; other site
1288394003017	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394003018	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394003019	dimer interface [polypeptide binding]; other site
1288394003020	putative CheW interface [polypeptide binding]; other site
1288394003021	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
1288394003022	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
1288394003023	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1288394003024	heterodimer interface [polypeptide binding]; other site
1288394003025	homodimer interface [polypeptide binding]; other site
1288394003026	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
1288394003027	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
1288394003028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394003029	dimer interface [polypeptide binding]; other site
1288394003030	conserved gate region; other site
1288394003031	ABC-ATPase subunit interface; other site
1288394003032	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1288394003033	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1288394003034	Walker A/P-loop; other site
1288394003035	ATP binding site [chemical binding]; other site
1288394003036	Q-loop/lid; other site
1288394003037	ABC transporter signature motif; other site
1288394003038	Walker B; other site
1288394003039	D-loop; other site
1288394003040	H-loop/switch region; other site
1288394003041	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1288394003042	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1288394003043	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1288394003044	nucleotide binding site [chemical binding]; other site
1288394003045	epoxyqueuosine reductase; Region: TIGR00276
1288394003046	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1288394003047	putative carbohydrate kinase; Provisional; Region: PRK10565
1288394003048	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1288394003049	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1288394003050	putative substrate binding site [chemical binding]; other site
1288394003051	putative ATP binding site [chemical binding]; other site
1288394003052	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1288394003053	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
1288394003054	AMIN domain; Region: AMIN; pfam11741
1288394003055	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1288394003056	active site
1288394003057	metal binding site [ion binding]; metal-binding site
1288394003058	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1288394003059	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394003060	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1288394003061	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394003062	ATP binding site [chemical binding]; other site
1288394003063	Mg2+ binding site [ion binding]; other site
1288394003064	G-X-G motif; other site
1288394003065	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
1288394003066	ATP binding site [chemical binding]; other site
1288394003067	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1288394003068	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1288394003069	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1288394003070	bacterial Hfq-like; Region: Hfq; cd01716
1288394003071	hexamer interface [polypeptide binding]; other site
1288394003072	Sm1 motif; other site
1288394003073	RNA binding site [nucleotide binding]; other site
1288394003074	Sm2 motif; other site
1288394003075	GTPase HflX; Provisional; Region: PRK11058
1288394003076	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1288394003077	HflX GTPase family; Region: HflX; cd01878
1288394003078	G1 box; other site
1288394003079	GTP/Mg2+ binding site [chemical binding]; other site
1288394003080	Switch I region; other site
1288394003081	G2 box; other site
1288394003082	G3 box; other site
1288394003083	Switch II region; other site
1288394003084	G4 box; other site
1288394003085	G5 box; other site
1288394003086	FtsH protease regulator HflK; Provisional; Region: PRK10930
1288394003087	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
1288394003088	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1288394003089	FtsH protease regulator HflC; Provisional; Region: PRK11029
1288394003090	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1288394003091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
1288394003092	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1288394003093	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1288394003094	substrate binding pocket [chemical binding]; other site
1288394003095	chain length determination region; other site
1288394003096	substrate-Mg2+ binding site; other site
1288394003097	catalytic residues [active]
1288394003098	aspartate-rich region 1; other site
1288394003099	active site lid residues [active]
1288394003100	aspartate-rich region 2; other site
1288394003101	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1288394003102	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1288394003103	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1288394003104	GTPase CgtA; Reviewed; Region: obgE; PRK12298
1288394003105	GTP1/OBG; Region: GTP1_OBG; pfam01018
1288394003106	Obg GTPase; Region: Obg; cd01898
1288394003107	G1 box; other site
1288394003108	GTP/Mg2+ binding site [chemical binding]; other site
1288394003109	Switch I region; other site
1288394003110	G2 box; other site
1288394003111	G3 box; other site
1288394003112	Switch II region; other site
1288394003113	G4 box; other site
1288394003114	G5 box; other site
1288394003115	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1288394003116	Nucleoside recognition; Region: Gate; pfam07670
1288394003117	AMP-binding domain protein; Validated; Region: PRK08315
1288394003118	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1288394003119	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1288394003120	acyl-activating enzyme (AAE) consensus motif; other site
1288394003121	putative AMP binding site [chemical binding]; other site
1288394003122	putative active site [active]
1288394003123	putative CoA binding site [chemical binding]; other site
1288394003124	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394003125	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394003126	hypothetical protein; Provisional; Region: PRK10508
1288394003127	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1288394003128	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1288394003129	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1288394003130	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394003131	non-specific DNA binding site [nucleotide binding]; other site
1288394003132	salt bridge; other site
1288394003133	sequence-specific DNA binding site [nucleotide binding]; other site
1288394003134	2TM domain; Region: 2TM; pfam13239
1288394003135	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
1288394003136	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
1288394003137	active site
1288394003138	metal binding site [ion binding]; metal-binding site
1288394003139	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
1288394003140	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1288394003141	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1288394003142	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1288394003143	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1288394003144	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
1288394003145	SurA N-terminal domain; Region: SurA_N; pfam09312
1288394003146	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1288394003147	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1288394003148	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
1288394003149	OstA-like protein; Region: OstA; cl00844
1288394003150	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1288394003151	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1288394003152	Phosphotransferase enzyme family; Region: APH; pfam01636
1288394003153	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1288394003154	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1288394003155	Substrate binding site; other site
1288394003156	metal-binding site
1288394003157	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
1288394003158	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1288394003159	putative metal binding site [ion binding]; other site
1288394003160	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1288394003161	HSP70 interaction site [polypeptide binding]; other site
1288394003162	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1288394003163	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1288394003164	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394003165	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394003166	ABC transporter; Region: ABC_tran_2; pfam12848
1288394003167	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394003168	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
1288394003169	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1288394003170	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1288394003171	active site
1288394003172	DNA binding site [nucleotide binding]
1288394003173	Int/Topo IB signature motif; other site
1288394003174	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1288394003175	GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508
1288394003176	DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442
1288394003177	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1288394003178	Catalytic site [active]
1288394003179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394003180	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1288394003181	non-specific DNA binding site [nucleotide binding]; other site
1288394003182	salt bridge; other site
1288394003183	sequence-specific DNA binding site [nucleotide binding]; other site
1288394003184	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
1288394003185	Ash protein family; Region: Phage_ASH; pfam10554
1288394003186	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1288394003187	Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752
1288394003188	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
1288394003189	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
1288394003190	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
1288394003191	Protein of unknown function (DUF968); Region: DUF968; pfam06147
1288394003192	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
1288394003193	uncharacterized phage protein; Region: phage_xxxx; TIGR02642
1288394003194	Antitermination protein; Region: Antiterm; pfam03589
1288394003195	Integrase core domain; Region: rve_2; pfam13333
1288394003196	Part of AAA domain; Region: AAA_19; pfam13245
1288394003197	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003198	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1288394003199	DNA methylase; Region: N6_N4_Mtase; pfam01555
1288394003200	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1288394003201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394003202	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1288394003203	Walker A motif; other site
1288394003204	ATP binding site [chemical binding]; other site
1288394003205	Walker B motif; other site
1288394003206	arginine finger; other site
1288394003207	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
1288394003208	active site
1288394003209	catalytic triad [active]
1288394003210	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1288394003211	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1288394003212	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
1288394003213	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1288394003214	catalytic residue [active]
1288394003215	Protein of unknown function (DUF2514); Region: DUF2514; pfam10721
1288394003216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
1288394003217	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1288394003218	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1288394003219	active site
1288394003220	Phage terminase, small subunit; Region: Terminase_4; pfam05119
1288394003221	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1288394003222	Phage-related protein [Function unknown]; Region: COG4695
1288394003223	Phage portal protein; Region: Phage_portal; pfam04860
1288394003224	Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022
1288394003225	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1288394003226	tandem repeat interface [polypeptide binding]; other site
1288394003227	oligomer interface [polypeptide binding]; other site
1288394003228	active site residues [active]
1288394003229	Rho Binding; Region: Rho_Binding; pfam08912
1288394003230	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1288394003231	Phage capsid family; Region: Phage_capsid; pfam05065
1288394003232	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959
1288394003233	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1288394003234	oligomerization interface [polypeptide binding]; other site
1288394003235	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1288394003236	tape measure domain; Region: tape_meas_nterm; TIGR02675
1288394003237	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1288394003238	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394003239	ligand binding site [chemical binding]; other site
1288394003240	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
1288394003241	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1288394003242	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1288394003243	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1288394003244	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394003245	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394003246	catalytic residue [active]
1288394003247	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
1288394003248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394003249	The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449
1288394003250	putative dimerization interface [polypeptide binding]; other site
1288394003251	putative substrate binding pocket [chemical binding]; other site
1288394003252	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1288394003253	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1288394003254	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1288394003255	Nucleoside recognition; Region: Gate; pfam07670
1288394003256	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1288394003257	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1288394003258	intersubunit interface [polypeptide binding]; other site
1288394003259	active site
1288394003260	catalytic residue [active]
1288394003261	EamA-like transporter family; Region: EamA; pfam00892
1288394003262	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1288394003263	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1288394003264	putative NAD(P) binding site [chemical binding]; other site
1288394003265	active site
1288394003266	putative substrate binding site [chemical binding]; other site
1288394003267	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1288394003268	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1288394003269	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1288394003270	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1288394003271	Walker A/P-loop; other site
1288394003272	ATP binding site [chemical binding]; other site
1288394003273	Q-loop/lid; other site
1288394003274	ABC transporter signature motif; other site
1288394003275	Walker B; other site
1288394003276	D-loop; other site
1288394003277	H-loop/switch region; other site
1288394003278	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1288394003279	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1288394003280	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394003281	ABC-ATPase subunit  interface; other site
1288394003282	dimer interface [polypeptide binding]; other site
1288394003283	putative PBP binding regions; other site
1288394003284	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1288394003285	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1288394003286	intersubunit interface [polypeptide binding]; other site
1288394003287	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
1288394003288	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1288394003289	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1288394003290	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1288394003291	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394003292	catalytic triad [active]
1288394003293	conserved cis-peptide bond; other site
1288394003294	Protein of unknown function, DUF399; Region: DUF399; pfam04187
1288394003295	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1288394003296	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394003297	N-terminal plug; other site
1288394003298	ligand-binding site [chemical binding]; other site
1288394003299	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
1288394003300	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394003301	non-specific DNA binding site [nucleotide binding]; other site
1288394003302	salt bridge; other site
1288394003303	sequence-specific DNA binding site [nucleotide binding]; other site
1288394003304	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
1288394003305	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1288394003306	Na binding site [ion binding]; other site
1288394003307	PAS domain; Region: PAS; smart00091
1288394003308	PAS fold; Region: PAS_7; pfam12860
1288394003309	putative active site [active]
1288394003310	heme pocket [chemical binding]; other site
1288394003311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394003312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394003313	dimer interface [polypeptide binding]; other site
1288394003314	phosphorylation site [posttranslational modification]
1288394003315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394003316	ATP binding site [chemical binding]; other site
1288394003317	Mg2+ binding site [ion binding]; other site
1288394003318	G-X-G motif; other site
1288394003319	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394003320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394003321	active site
1288394003322	phosphorylation site [posttranslational modification]
1288394003323	intermolecular recognition site; other site
1288394003324	dimerization interface [polypeptide binding]; other site
1288394003325	N-terminal Early set domain associated with the catalytic domain of chitinase; Region: E_set_Chitinase_N; cd02848
1288394003326	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
1288394003327	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1288394003328	active site
1288394003329	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
1288394003330	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1288394003331	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1288394003332	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1288394003333	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1288394003334	Peptidase M66; Region: Peptidase_M66; pfam10462
1288394003335	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1288394003336	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1288394003337	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1288394003338	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
1288394003339	putative sugar binding site [chemical binding]; other site
1288394003340	catalytic residues [active]
1288394003341	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1288394003342	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1288394003343	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003344	S-adenosylmethionine binding site [chemical binding]; other site
1288394003345	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
1288394003346	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394003347	ligand binding site [chemical binding]; other site
1288394003348	flexible hinge region; other site
1288394003349	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1288394003350	putative switch regulator; other site
1288394003351	non-specific DNA interactions [nucleotide binding]; other site
1288394003352	DNA binding site [nucleotide binding]
1288394003353	sequence specific DNA binding site [nucleotide binding]; other site
1288394003354	putative cAMP binding site [chemical binding]; other site
1288394003355	OsmC-like protein; Region: OsmC; cl00767
1288394003356	lysozyme inhibitor; Provisional; Region: PRK11372
1288394003357	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1288394003358	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
1288394003359	phosphoribulokinase; Provisional; Region: PRK15453
1288394003360	active site
1288394003361	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
1288394003362	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
1288394003363	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
1288394003364	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1288394003365	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
1288394003366	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
1288394003367	putative active site [active]
1288394003368	putative catalytic site [active]
1288394003369	putative Zn binding site [ion binding]; other site
1288394003370	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
1288394003371	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1288394003372	active site
1288394003373	substrate binding site [chemical binding]; other site
1288394003374	cosubstrate binding site; other site
1288394003375	catalytic site [active]
1288394003376	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
1288394003377	active site
1288394003378	hexamer interface [polypeptide binding]; other site
1288394003379	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
1288394003380	NAD binding site [chemical binding]; other site
1288394003381	substrate binding site [chemical binding]; other site
1288394003382	active site
1288394003383	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1288394003384	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1288394003385	Ligand binding site; other site
1288394003386	Putative Catalytic site; other site
1288394003387	DXD motif; other site
1288394003388	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1288394003389	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1288394003390	inhibitor-cofactor binding pocket; inhibition site
1288394003391	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394003392	catalytic residue [active]
1288394003393	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1288394003394	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1288394003395	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1288394003396	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1288394003397	hypothetical protein; Provisional; Region: PRK04966
1288394003398	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394003399	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394003400	metal binding site [ion binding]; metal-binding site
1288394003401	active site
1288394003402	I-site; other site
1288394003403	putative hydrolase; Provisional; Region: PRK10985
1288394003404	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1288394003405	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394003406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394003407	active site
1288394003408	phosphorylation site [posttranslational modification]
1288394003409	intermolecular recognition site; other site
1288394003410	dimerization interface [polypeptide binding]; other site
1288394003411	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
1288394003412	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1288394003413	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1288394003414	SlyX; Region: SlyX; pfam04102
1288394003415	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1288394003416	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1288394003417	structural tetrad; other site
1288394003418	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1288394003419	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1288394003420	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1288394003421	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1288394003422	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394003423	active site
1288394003424	phosphorylation site [posttranslational modification]
1288394003425	intermolecular recognition site; other site
1288394003426	dimerization interface [polypeptide binding]; other site
1288394003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394003428	Walker A motif; other site
1288394003429	ATP binding site [chemical binding]; other site
1288394003430	Walker B motif; other site
1288394003431	arginine finger; other site
1288394003432	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394003433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1288394003434	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
1288394003435	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
1288394003436	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1288394003437	active site
1288394003438	metal binding site [ion binding]; metal-binding site
1288394003439	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1288394003440	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1288394003441	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394003442	Tim44-like domain; Region: Tim44; pfam04280
1288394003443	replicative DNA helicase; Provisional; Region: PRK08006
1288394003444	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1288394003445	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1288394003446	Walker A motif; other site
1288394003447	ATP binding site [chemical binding]; other site
1288394003448	Walker B motif; other site
1288394003449	DNA binding loops [nucleotide binding]
1288394003450	replicative DNA helicase; Provisional; Region: PRK08840
1288394003451	alanine racemase; Reviewed; Region: alr; PRK00053
1288394003452	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1288394003453	active site
1288394003454	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394003455	substrate binding site [chemical binding]; other site
1288394003456	catalytic residues [active]
1288394003457	dimer interface [polypeptide binding]; other site
1288394003458	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394003459	putative protease; Provisional; Region: PRK15452
1288394003460	Peptidase family U32; Region: Peptidase_U32; pfam01136
1288394003461	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394003462	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1288394003463	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1288394003464	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394003465	catalytic residue [active]
1288394003466	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1288394003467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394003468	active site
1288394003469	phosphorylation site [posttranslational modification]
1288394003470	intermolecular recognition site; other site
1288394003471	dimerization interface [polypeptide binding]; other site
1288394003472	CheB methylesterase; Region: CheB_methylest; pfam01339
1288394003473	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13498
1288394003474	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1288394003475	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1288394003476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003477	S-adenosylmethionine binding site [chemical binding]; other site
1288394003478	PAS domain; Region: PAS_9; pfam13426
1288394003479	PAS domain; Region: PAS_9; pfam13426
1288394003480	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394003481	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394003482	dimer interface [polypeptide binding]; other site
1288394003483	putative CheW interface [polypeptide binding]; other site
1288394003484	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1288394003485	putative CheA interaction surface; other site
1288394003486	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394003487	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394003488	dimerization interface [polypeptide binding]; other site
1288394003489	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394003490	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394003491	dimer interface [polypeptide binding]; other site
1288394003492	putative CheW interface [polypeptide binding]; other site
1288394003493	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1288394003494	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394003495	putative binding surface; other site
1288394003496	active site
1288394003497	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1288394003498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394003499	ATP binding site [chemical binding]; other site
1288394003500	Mg2+ binding site [ion binding]; other site
1288394003501	G-X-G motif; other site
1288394003502	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1288394003503	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1288394003504	anti sigma factor interaction site; other site
1288394003505	regulatory phosphorylation site [posttranslational modification]; other site
1288394003506	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394003507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394003508	active site
1288394003509	phosphorylation site [posttranslational modification]
1288394003510	intermolecular recognition site; other site
1288394003511	dimerization interface [polypeptide binding]; other site
1288394003512	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1288394003513	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1288394003514	dimer interface [polypeptide binding]; other site
1288394003515	active site
1288394003516	CoA binding pocket [chemical binding]; other site
1288394003517	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394003518	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394003519	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394003520	substrate binding pocket [chemical binding]; other site
1288394003521	dimerization interface [polypeptide binding]; other site
1288394003522	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394003523	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1288394003524	Peptidase family U32; Region: Peptidase_U32; pfam01136
1288394003525	Collagenase; Region: DUF3656; pfam12392
1288394003526	ASCH domain; Region: ASCH; pfam04266
1288394003527	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
1288394003528	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1288394003529	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1288394003530	DNA binding site [nucleotide binding]
1288394003531	active site
1288394003532	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1288394003533	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1288394003534	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394003535	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394003536	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1288394003537	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1288394003538	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1288394003539	minor groove reading motif; other site
1288394003540	helix-hairpin-helix signature motif; other site
1288394003541	substrate binding pocket [chemical binding]; other site
1288394003542	active site
1288394003543	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1288394003544	active site
1288394003545	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1288394003546	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1288394003547	active site
1288394003548	Zn binding site [ion binding]; other site
1288394003549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
1288394003550	Smr domain; Region: Smr; pfam01713
1288394003551	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
1288394003552	TraB family; Region: TraB; pfam01963
1288394003553	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
1288394003554	short chain dehydrogenase; Provisional; Region: PRK05993
1288394003555	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1288394003556	NADP binding site [chemical binding]; other site
1288394003557	active site
1288394003558	steroid binding site; other site
1288394003559	outer membrane porin, OprD family; Region: OprD; pfam03573
1288394003560	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394003561	dimer interface [polypeptide binding]; other site
1288394003562	putative CheW interface [polypeptide binding]; other site
1288394003563	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1288394003564	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1288394003565	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1288394003566	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1288394003567	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1288394003568	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1288394003569	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1288394003570	integrase; Provisional; Region: PRK09692
1288394003571	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1288394003572	active site
1288394003573	Int/Topo IB signature motif; other site
1288394003574	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1288394003575	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1288394003576	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1288394003577	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1288394003578	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003579	S-adenosylmethionine binding site [chemical binding]; other site
1288394003580	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1288394003581	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1288394003582	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1288394003583	Walker A/P-loop; other site
1288394003584	ATP binding site [chemical binding]; other site
1288394003585	Q-loop/lid; other site
1288394003586	ABC transporter signature motif; other site
1288394003587	Walker B; other site
1288394003588	D-loop; other site
1288394003589	H-loop/switch region; other site
1288394003590	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1288394003591	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394003592	dimer interface [polypeptide binding]; other site
1288394003593	putative PBP binding regions; other site
1288394003594	ABC-ATPase subunit  interface; other site
1288394003595	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1288394003596	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1288394003597	intersubunit interface [polypeptide binding]; other site
1288394003598	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1288394003599	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394003600	ligand binding site [chemical binding]; other site
1288394003601	flexible hinge region; other site
1288394003602	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1288394003603	putative switch regulator; other site
1288394003604	non-specific DNA interactions [nucleotide binding]; other site
1288394003605	DNA binding site [nucleotide binding]
1288394003606	sequence specific DNA binding site [nucleotide binding]; other site
1288394003607	putative cAMP binding site [chemical binding]; other site
1288394003608	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1288394003609	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394003610	N-terminal plug; other site
1288394003611	ligand-binding site [chemical binding]; other site
1288394003612	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
1288394003613	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394003614	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1288394003615	ABC transporter signature motif; other site
1288394003616	Walker B; other site
1288394003617	D-loop; other site
1288394003618	H-loop/switch region; other site
1288394003619	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1288394003620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394003621	dimer interface [polypeptide binding]; other site
1288394003622	conserved gate region; other site
1288394003623	putative PBP binding loops; other site
1288394003624	ABC-ATPase subunit interface; other site
1288394003625	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1288394003626	C2 domain; Region: C2; cl14603
1288394003627	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003628	S-adenosylmethionine binding site [chemical binding]; other site
1288394003629	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1288394003630	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394003631	N-terminal plug; other site
1288394003632	ligand-binding site [chemical binding]; other site
1288394003633	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1288394003634	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394003635	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394003636	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1288394003637	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1288394003638	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1288394003639	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1288394003640	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1288394003641	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1288394003642	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1288394003643	Catalytic site [active]
1288394003644	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394003645	nucleotide binding region [chemical binding]; other site
1288394003646	ATP-binding site [chemical binding]; other site
1288394003647	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1288394003648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394003649	ATP binding site [chemical binding]; other site
1288394003650	putative Mg++ binding site [ion binding]; other site
1288394003651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394003652	nucleotide binding region [chemical binding]; other site
1288394003653	ATP-binding site [chemical binding]; other site
1288394003654	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
1288394003655	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1288394003656	ATP binding site [chemical binding]; other site
1288394003657	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1288394003658	putative Mg++ binding site [ion binding]; other site
1288394003659	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394003660	nucleotide binding region [chemical binding]; other site
1288394003661	ATP-binding site [chemical binding]; other site
1288394003662	PLD-like domain; Region: PLDc_2; pfam13091
1288394003663	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1288394003664	putative active site [active]
1288394003665	catalytic site [active]
1288394003666	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1288394003667	active site
1288394003668	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
1288394003669	DGQHR domain; Region: DGQHR; TIGR03187
1288394003670	Queuine tRNA-ribosyltransferase; Region: TGT; pfam01702
1288394003671	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1288394003672	Ligand Binding Site [chemical binding]; other site
1288394003673	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1288394003674	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1288394003675	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
1288394003676	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1288394003677	MPN+ (JAMM) motif; other site
1288394003678	Zinc-binding site [ion binding]; other site
1288394003679	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
1288394003680	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1288394003681	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394003682	non-specific DNA binding site [nucleotide binding]; other site
1288394003683	salt bridge; other site
1288394003684	sequence-specific DNA binding site [nucleotide binding]; other site
1288394003685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1288394003686	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1288394003687	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
1288394003688	Predicted integral membrane protein [Function unknown]; Region: COG5616
1288394003689	LPP20 lipoprotein; Region: LPP20; pfam02169
1288394003690	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
1288394003691	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
1288394003692	Prephenate dehydratase; Region: PDT; pfam00800
1288394003693	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1288394003694	putative L-Phe binding site [chemical binding]; other site
1288394003695	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1288394003696	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394003697	motif II; other site
1288394003698	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1288394003699	Ligand Binding Site [chemical binding]; other site
1288394003700	Protein of unknown function (DUF3157); Region: DUF3157; pfam11355
1288394003701	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1288394003702	Protein of unknown function (DUF523); Region: DUF523; pfam04463
1288394003703	Uncharacterized conserved protein [Function unknown]; Region: COG3272
1288394003704	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1288394003705	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1288394003706	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1288394003707	DNA binding residues [nucleotide binding]
1288394003708	B12 binding domain; Region: B12-binding_2; cl03653
1288394003709	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
1288394003710	DNA photolyase; Region: DNA_photolyase; pfam00875
1288394003711	SnoaL-like domain; Region: SnoaL_2; pfam12680
1288394003712	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394003713	NAD(P) binding site [chemical binding]; other site
1288394003714	active site
1288394003715	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1288394003716	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1288394003717	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1288394003718	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1288394003719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003720	S-adenosylmethionine binding site [chemical binding]; other site
1288394003721	Protein of unknown function (DUF2878); Region: DUF2878; pfam11086
1288394003722	Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726
1288394003723	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1288394003724	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1288394003725	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1288394003726	dimerization interface [polypeptide binding]; other site
1288394003727	DPS ferroxidase diiron center [ion binding]; other site
1288394003728	ion pore; other site
1288394003729	hybrid cluster protein; Provisional; Region: PRK05290
1288394003730	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394003731	ACS interaction site; other site
1288394003732	CODH interaction site; other site
1288394003733	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394003734	ACS interaction site; other site
1288394003735	CODH interaction site; other site
1288394003736	metal cluster binding site [ion binding]; other site
1288394003737	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1288394003738	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1288394003739	FAD binding pocket [chemical binding]; other site
1288394003740	FAD binding motif [chemical binding]; other site
1288394003741	phosphate binding motif [ion binding]; other site
1288394003742	beta-alpha-beta structure motif; other site
1288394003743	NAD binding pocket [chemical binding]; other site
1288394003744	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394003745	catalytic loop [active]
1288394003746	iron binding site [ion binding]; other site
1288394003747	UDP-glucose 4-epimerase; Region: PLN02240
1288394003748	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1288394003749	NAD binding site [chemical binding]; other site
1288394003750	homodimer interface [polypeptide binding]; other site
1288394003751	active site
1288394003752	substrate binding site [chemical binding]; other site
1288394003753	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1288394003754	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1288394003755	catalytic residues [active]
1288394003756	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1288394003757	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1288394003758	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394003759	DNA binding residues [nucleotide binding]
1288394003760	dimerization interface [polypeptide binding]; other site
1288394003761	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1288394003762	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1288394003763	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1288394003764	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1288394003765	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
1288394003766	active site
1288394003767	conformational flexibility of ligand binding pocket; other site
1288394003768	ADP-ribosylating toxin turn-turn motif; other site
1288394003769	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
1288394003770	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
1288394003771	Protein of unknown function (DUF2931); Region: DUF2931; pfam11153
1288394003772	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394003773	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394003774	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
1288394003775	putative dimerization interface [polypeptide binding]; other site
1288394003776	putative substrate binding pocket [chemical binding]; other site
1288394003777	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
1288394003778	acetolactate synthase; Reviewed; Region: PRK08617
1288394003779	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1288394003780	PYR/PP interface [polypeptide binding]; other site
1288394003781	dimer interface [polypeptide binding]; other site
1288394003782	TPP binding site [chemical binding]; other site
1288394003783	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1288394003784	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1288394003785	TPP-binding site [chemical binding]; other site
1288394003786	dimer interface [polypeptide binding]; other site
1288394003787	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
1288394003788	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1288394003789	conserved cys residue [active]
1288394003790	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1288394003791	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1288394003792	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1288394003793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1288394003794	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1288394003795	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
1288394003796	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1288394003797	AmpG-like permease; Region: 2A0125; TIGR00901
1288394003798	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1288394003799	active site
1288394003800	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
1288394003801	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
1288394003802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394003803	S-adenosylmethionine binding site [chemical binding]; other site
1288394003804	BolA-like protein; Region: BolA; cl00386
1288394003805	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
1288394003806	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394003807	E3 interaction surface; other site
1288394003808	lipoyl attachment site [posttranslational modification]; other site
1288394003809	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
1288394003810	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
1288394003811	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
1288394003812	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
1288394003813	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
1288394003814	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
1288394003815	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
1288394003816	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394003817	catalytic loop [active]
1288394003818	iron binding site [ion binding]; other site
1288394003819	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
1288394003820	FAD binding pocket [chemical binding]; other site
1288394003821	FAD binding motif [chemical binding]; other site
1288394003822	phosphate binding motif [ion binding]; other site
1288394003823	beta-alpha-beta structure motif; other site
1288394003824	NAD binding pocket [chemical binding]; other site
1288394003825	ApbE family; Region: ApbE; pfam02424
1288394003826	Protein of unknown function (DUF539); Region: DUF539; cl01129
1288394003827	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1288394003828	active site
1288394003829	DNA polymerase IV; Validated; Region: PRK02406
1288394003830	DNA binding site [nucleotide binding]
1288394003831	Cache domain; Region: Cache_1; pfam02743
1288394003832	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394003833	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394003834	dimerization interface [polypeptide binding]; other site
1288394003835	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394003836	dimer interface [polypeptide binding]; other site
1288394003837	putative CheW interface [polypeptide binding]; other site
1288394003838	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1288394003839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394003840	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1288394003841	dimerization interface [polypeptide binding]; other site
1288394003842	substrate binding pocket [chemical binding]; other site
1288394003843	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
1288394003844	Protein of unknown function (DUF423); Region: DUF423; pfam04241
1288394003845	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
1288394003846	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1288394003847	tartrate dehydrogenase; Region: TTC; TIGR02089
1288394003848	isocitrate dehydrogenase; Provisional; Region: PRK08997
1288394003849	flap endonuclease-like protein; Provisional; Region: PRK09482
1288394003850	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1288394003851	active site
1288394003852	metal binding site 1 [ion binding]; metal-binding site
1288394003853	putative 5' ssDNA interaction site; other site
1288394003854	metal binding site 3; metal-binding site
1288394003855	metal binding site 2 [ion binding]; metal-binding site
1288394003856	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1288394003857	putative DNA binding site [nucleotide binding]; other site
1288394003858	putative metal binding site [ion binding]; other site
1288394003859	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1288394003860	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
1288394003861	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394003862	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394003863	metal binding site [ion binding]; metal-binding site
1288394003864	active site
1288394003865	I-site; other site
1288394003866	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1288394003867	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
1288394003868	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
1288394003869	Syd protein (SUKH-2); Region: Syd; pfam07348
1288394003870	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
1288394003871	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
1288394003872	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
1288394003873	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
1288394003874	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
1288394003875	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1288394003876	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
1288394003877	probable active site [active]
1288394003878	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1288394003879	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1288394003880	trimer interface; other site
1288394003881	sugar binding site [chemical binding]; other site
1288394003882	Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148
1288394003883	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
1288394003884	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394003885	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394003886	active site turn [active]
1288394003887	phosphorylation site [posttranslational modification]
1288394003888	hypothetical protein; Provisional; Region: PRK13677
1288394003889	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1288394003890	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1288394003891	trimer interface [polypeptide binding]; other site
1288394003892	active site
1288394003893	substrate binding site [chemical binding]; other site
1288394003894	CoA binding site [chemical binding]; other site
1288394003895	PII uridylyl-transferase; Provisional; Region: PRK05007
1288394003896	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1288394003897	metal binding triad; other site
1288394003898	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1288394003899	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394003900	Zn2+ binding site [ion binding]; other site
1288394003901	Mg2+ binding site [ion binding]; other site
1288394003902	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1288394003903	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1288394003904	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1288394003905	active site
1288394003906	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1288394003907	rRNA interaction site [nucleotide binding]; other site
1288394003908	S8 interaction site; other site
1288394003909	putative laminin-1 binding site; other site
1288394003910	elongation factor Ts; Provisional; Region: tsf; PRK09377
1288394003911	UBA/TS-N domain; Region: UBA; pfam00627
1288394003912	Elongation factor TS; Region: EF_TS; pfam00889
1288394003913	Elongation factor TS; Region: EF_TS; pfam00889
1288394003914	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1288394003915	putative nucleotide binding site [chemical binding]; other site
1288394003916	uridine monophosphate binding site [chemical binding]; other site
1288394003917	homohexameric interface [polypeptide binding]; other site
1288394003918	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1288394003919	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1288394003920	hinge region; other site
1288394003921	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1288394003922	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1288394003923	catalytic residue [active]
1288394003924	putative FPP diphosphate  binding site; other site
1288394003925	putative FPP binding hydrophobic cleft; other site
1288394003926	dimer interface [polypeptide binding]; other site
1288394003927	putative IPP diphosphate binding site; other site
1288394003928	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
1288394003929	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1288394003930	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1288394003931	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1288394003932	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1288394003933	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1288394003934	zinc metallopeptidase RseP; Provisional; Region: PRK10779
1288394003935	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1288394003936	active site
1288394003937	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1288394003938	protein binding site [polypeptide binding]; other site
1288394003939	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1288394003940	protein binding site [polypeptide binding]; other site
1288394003941	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1288394003942	putative substrate binding region [chemical binding]; other site
1288394003943	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
1288394003944	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1288394003945	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1288394003946	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1288394003947	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1288394003948	Surface antigen; Region: Bac_surface_Ag; pfam01103
1288394003949	periplasmic chaperone; Provisional; Region: PRK10780
1288394003950	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
1288394003951	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1288394003952	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1288394003953	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1288394003954	trimer interface [polypeptide binding]; other site
1288394003955	active site
1288394003956	UDP-GlcNAc binding site [chemical binding]; other site
1288394003957	lipid binding site [chemical binding]; lipid-binding site
1288394003958	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1288394003959	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1288394003960	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1288394003961	active site
1288394003962	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1288394003963	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1288394003964	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1288394003965	RNA/DNA hybrid binding site [nucleotide binding]; other site
1288394003966	active site
1288394003967	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1288394003968	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1288394003969	putative active site [active]
1288394003970	putative PHP Thumb interface [polypeptide binding]; other site
1288394003971	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1288394003972	generic binding surface II; other site
1288394003973	generic binding surface I; other site
1288394003974	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1288394003975	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1288394003976	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
1288394003977	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394003978	DNA binding site [nucleotide binding]
1288394003979	lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435
1288394003980	lysine decarboxylase CadA; Provisional; Region: PRK15400
1288394003981	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
1288394003982	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1288394003983	homodimer interface [polypeptide binding]; other site
1288394003984	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394003985	catalytic residue [active]
1288394003986	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1288394003987	pyridoxamine kinase; Validated; Region: PRK05756
1288394003988	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1288394003989	dimer interface [polypeptide binding]; other site
1288394003990	pyridoxal binding site [chemical binding]; other site
1288394003991	ATP binding site [chemical binding]; other site
1288394003992	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1288394003993	putative efflux protein, MATE family; Region: matE; TIGR00797
1288394003994	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394003995	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394003996	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394003997	dimerization interface [polypeptide binding]; other site
1288394003998	serine transporter; Region: stp; TIGR00814
1288394003999	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1288394004000	putative hydrolase; Provisional; Region: PRK02113
1288394004001	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1288394004002	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394004003	LysR family transcriptional regulator; Provisional; Region: PRK14997
1288394004004	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394004005	putative effector binding pocket; other site
1288394004006	dimerization interface [polypeptide binding]; other site
1288394004007	putative transporter; Provisional; Region: PRK11021
1288394004008	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1288394004009	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394004010	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1288394004011	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394004012	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394004013	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
1288394004014	dimer interface [polypeptide binding]; other site
1288394004015	putative inhibitory loop; other site
1288394004016	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1288394004017	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1288394004018	active site
1288394004019	Zn binding site [ion binding]; other site
1288394004020	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
1288394004021	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1288394004022	Ligand Binding Site [chemical binding]; other site
1288394004023	TilS substrate binding domain; Region: TilS; pfam09179
1288394004024	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
1288394004025	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394004026	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394004027	metal binding site [ion binding]; metal-binding site
1288394004028	active site
1288394004029	I-site; other site
1288394004030	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1288394004031	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1288394004032	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1288394004033	TrkA-N domain; Region: TrkA_N; pfam02254
1288394004034	TrkA-C domain; Region: TrkA_C; pfam02080
1288394004035	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1288394004036	nucleophile elbow; other site
1288394004037	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394004038	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1288394004039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394004040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394004041	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1288394004042	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394004043	active site
1288394004044	phosphorylation site [posttranslational modification]
1288394004045	intermolecular recognition site; other site
1288394004046	dimerization interface [polypeptide binding]; other site
1288394004047	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394004048	DNA binding residues [nucleotide binding]
1288394004049	dimerization interface [polypeptide binding]; other site
1288394004050	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394004051	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1288394004052	substrate binding pocket (H-site) [chemical binding]; other site
1288394004053	N-terminal domain interface [polypeptide binding]; other site
1288394004054	alpha-amylase; Reviewed; Region: malS; PRK09505
1288394004055	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1288394004056	active site
1288394004057	catalytic site [active]
1288394004058	Predicted membrane protein [Function unknown]; Region: COG2246
1288394004059	GtrA-like protein; Region: GtrA; pfam04138
1288394004060	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1288394004061	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1288394004062	Ligand binding site; other site
1288394004063	Putative Catalytic site; other site
1288394004064	DXD motif; other site
1288394004065	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394004066	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394004067	substrate binding pocket [chemical binding]; other site
1288394004068	membrane-bound complex binding site; other site
1288394004069	hinge residues; other site
1288394004070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1288394004071	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1288394004072	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1288394004073	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1288394004074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1288394004075	Peptidase M15; Region: Peptidase_M15_3; cl01194
1288394004076	Predicted membrane protein [Function unknown]; Region: COG2860
1288394004077	UPF0126 domain; Region: UPF0126; pfam03458
1288394004078	UPF0126 domain; Region: UPF0126; pfam03458
1288394004079	putative sulfate transport protein CysZ; Validated; Region: PRK04949
1288394004080	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1288394004081	AAA domain; Region: AAA_23; pfam13476
1288394004082	Walker A/P-loop; other site
1288394004083	ATP binding site [chemical binding]; other site
1288394004084	Q-loop/lid; other site
1288394004085	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1288394004086	ABC transporter signature motif; other site
1288394004087	Walker B; other site
1288394004088	D-loop; other site
1288394004089	H-loop/switch region; other site
1288394004090	ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354
1288394004091	FtsZ protein binding site [polypeptide binding]; other site
1288394004092	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1288394004093	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1288394004094	nucleotide binding pocket [chemical binding]; other site
1288394004095	K-X-D-G motif; other site
1288394004096	catalytic site [active]
1288394004097	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1288394004098	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1288394004099	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1288394004100	Dimer interface [polypeptide binding]; other site
1288394004101	BRCT sequence motif; other site
1288394004102	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1288394004103	ATP cone domain; Region: ATP-cone; pfam03477
1288394004104	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1288394004105	effector binding site; other site
1288394004106	active site
1288394004107	Zn binding site [ion binding]; other site
1288394004108	glycine loop; other site
1288394004109	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
1288394004110	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394004111	FeS/SAM binding site; other site
1288394004112	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1288394004113	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1288394004114	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
1288394004115	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394004116	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394004117	substrate binding pocket [chemical binding]; other site
1288394004118	membrane-bound complex binding site; other site
1288394004119	hinge residues; other site
1288394004120	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
1288394004121	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1288394004122	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394004123	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394004124	transcriptional regulator SlyA; Provisional; Region: PRK03573
1288394004125	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1288394004126	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
1288394004127	malate dehydrogenase; Provisional; Region: PRK13529
1288394004128	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1288394004129	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1288394004130	NAD(P) binding pocket [chemical binding]; other site
1288394004131	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1288394004132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394004133	ATP binding site [chemical binding]; other site
1288394004134	Mg2+ binding site [ion binding]; other site
1288394004135	G-X-G motif; other site
1288394004136	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1288394004137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394004138	active site
1288394004139	phosphorylation site [posttranslational modification]
1288394004140	intermolecular recognition site; other site
1288394004141	dimerization interface [polypeptide binding]; other site
1288394004142	Transcriptional regulator; Region: CitT; pfam12431
1288394004143	EamA-like transporter family; Region: EamA; pfam00892
1288394004144	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1288394004145	EamA-like transporter family; Region: EamA; pfam00892
1288394004146	Cupin domain; Region: Cupin_2; cl17218
1288394004147	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394004148	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394004149	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1288394004150	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1288394004151	NAD(P) binding site [chemical binding]; other site
1288394004152	catalytic residues [active]
1288394004153	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1288394004154	GAF domain; Region: GAF; pfam01590
1288394004155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394004156	Walker A motif; other site
1288394004157	ATP binding site [chemical binding]; other site
1288394004158	Walker B motif; other site
1288394004159	arginine finger; other site
1288394004160	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1288394004161	DNA-binding interface [nucleotide binding]; DNA binding site
1288394004162	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1288394004163	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1288394004164	FAD binding site [chemical binding]; other site
1288394004165	substrate binding pocket [chemical binding]; other site
1288394004166	catalytic base [active]
1288394004167	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1288394004168	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1288394004169	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394004170	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1288394004171	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1288394004172	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394004173	active site
1288394004174	phosphorylation site [posttranslational modification]
1288394004175	intermolecular recognition site; other site
1288394004176	dimerization interface [polypeptide binding]; other site
1288394004177	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394004178	DNA binding site [nucleotide binding]
1288394004179	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
1288394004180	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
1288394004181	PAS domain; Region: PAS; smart00091
1288394004182	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394004183	dimer interface [polypeptide binding]; other site
1288394004184	phosphorylation site [posttranslational modification]
1288394004185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394004186	ATP binding site [chemical binding]; other site
1288394004187	Mg2+ binding site [ion binding]; other site
1288394004188	G-X-G motif; other site
1288394004189	PBP superfamily domain; Region: PBP_like_2; cl17296
1288394004190	Peptidase family M48; Region: Peptidase_M48; pfam01435
1288394004191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394004192	Coenzyme A binding pocket [chemical binding]; other site
1288394004193	fructokinase; Reviewed; Region: PRK09557
1288394004194	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1288394004195	nucleotide binding site [chemical binding]; other site
1288394004196	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1288394004197	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
1288394004198	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1288394004199	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1288394004200	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1288394004201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394004202	Walker A/P-loop; other site
1288394004203	ATP binding site [chemical binding]; other site
1288394004204	Q-loop/lid; other site
1288394004205	ABC transporter signature motif; other site
1288394004206	Walker B; other site
1288394004207	D-loop; other site
1288394004208	H-loop/switch region; other site
1288394004209	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1288394004210	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1288394004211	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
1288394004212	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
1288394004213	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
1288394004214	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1288394004215	nudix motif; other site
1288394004216	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1288394004217	acyl-activating enzyme (AAE) consensus motif; other site
1288394004218	active site
1288394004219	AMP binding site [chemical binding]; other site
1288394004220	CoA binding site [chemical binding]; other site
1288394004221	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1288394004222	catalytic triad [active]
1288394004223	dimer interface [polypeptide binding]; other site
1288394004224	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
1288394004225	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1288394004226	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1288394004227	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1288394004228	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1288394004229	dimer interface [polypeptide binding]; other site
1288394004230	active site
1288394004231	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394004232	catalytic residues [active]
1288394004233	substrate binding site [chemical binding]; other site
1288394004234	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1288394004235	amino acid carrier protein; Region: agcS; TIGR00835
1288394004236	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1288394004237	xanthine permease; Region: pbuX; TIGR03173
1288394004238	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394004239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394004240	metal binding site [ion binding]; metal-binding site
1288394004241	active site
1288394004242	I-site; other site
1288394004243	hypothetical protein; Provisional; Region: PRK11037
1288394004244	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1288394004245	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1288394004246	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394004247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394004248	malate dehydrogenase; Provisional; Region: PRK13529
1288394004249	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1288394004250	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1288394004251	NAD(P) binding site [chemical binding]; other site
1288394004252	outer membrane protein A; Reviewed; Region: PRK10808
1288394004253	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1288394004254	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394004255	ligand binding site [chemical binding]; other site
1288394004256	outer membrane protein A; Reviewed; Region: PRK10808
1288394004257	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1288394004258	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394004259	ligand binding site [chemical binding]; other site
1288394004260	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1288394004261	outer membrane protein A; Reviewed; Region: PRK10808
1288394004262	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394004263	ligand binding site [chemical binding]; other site
1288394004264	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394004265	non-specific DNA binding site [nucleotide binding]; other site
1288394004266	salt bridge; other site
1288394004267	sequence-specific DNA binding site [nucleotide binding]; other site
1288394004268	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1288394004269	Na2 binding site [ion binding]; other site
1288394004270	putative substrate binding site 1 [chemical binding]; other site
1288394004271	Na binding site 1 [ion binding]; other site
1288394004272	putative substrate binding site 2 [chemical binding]; other site
1288394004273	hypothetical protein; Provisional; Region: PRK10279
1288394004274	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
1288394004275	active site
1288394004276	nucleophile elbow; other site
1288394004277	Cache domain; Region: Cache_1; pfam02743
1288394004278	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394004279	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394004280	metal binding site [ion binding]; metal-binding site
1288394004281	active site
1288394004282	I-site; other site
1288394004283	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1288394004284	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394004285	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394004286	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1288394004287	hypothetical protein; Provisional; Region: PRK01254
1288394004288	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
1288394004289	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
1288394004290	DinB family; Region: DinB; cl17821
1288394004291	DinB superfamily; Region: DinB_2; pfam12867
1288394004292	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1288394004293	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1288394004294	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1288394004295	active site
1288394004296	putative DNA-binding cleft [nucleotide binding]; other site
1288394004297	dimer interface [polypeptide binding]; other site
1288394004298	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1288394004299	amphipathic channel; other site
1288394004300	Asn-Pro-Ala signature motifs; other site
1288394004301	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1288394004302	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394004303	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394004304	catalytic residue [active]
1288394004305	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
1288394004306	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1288394004307	active site
1288394004308	Ca binding site [ion binding]; other site
1288394004309	catalytic site [active]
1288394004310	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1288394004311	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394004312	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394004313	Coenzyme A binding pocket [chemical binding]; other site
1288394004314	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
1288394004315	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1288394004316	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1288394004317	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
1288394004318	putative active site [active]
1288394004319	catalytic site [active]
1288394004320	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1288394004321	putative active site [active]
1288394004322	catalytic site [active]
1288394004323	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
1288394004324	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1288394004325	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1288394004326	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1288394004327	putative active site [active]
1288394004328	putative substrate binding site [chemical binding]; other site
1288394004329	putative cosubstrate binding site; other site
1288394004330	catalytic site [active]
1288394004331	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
1288394004332	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
1288394004333	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
1288394004334	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1288394004335	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394004336	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1288394004337	NlpC/P60 family; Region: NLPC_P60; pfam00877
1288394004338	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
1288394004339	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394004340	S-adenosylmethionine binding site [chemical binding]; other site
1288394004341	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1288394004342	putative active site [active]
1288394004343	putative catalytic site [active]
1288394004344	Protein of unknown function, DUF481; Region: DUF481; cl01213
1288394004345	L,D-transpeptidase; Provisional; Region: PRK10190
1288394004346	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394004347	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1288394004348	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
1288394004349	PLD-like domain; Region: PLDc_2; pfam13091
1288394004350	putative active site [active]
1288394004351	catalytic site [active]
1288394004352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394004353	ATP binding site [chemical binding]; other site
1288394004354	putative Mg++ binding site [ion binding]; other site
1288394004355	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1288394004356	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394004357	nucleotide binding region [chemical binding]; other site
1288394004358	ATP-binding site [chemical binding]; other site
1288394004359	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
1288394004360	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
1288394004361	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
1288394004362	Protein of unknown function (DUF499); Region: DUF499; pfam04465
1288394004363	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1288394004364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1288394004365	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
1288394004366	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1288394004367	MPN+ (JAMM) motif; other site
1288394004368	Zinc-binding site [ion binding]; other site
1288394004369	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
1288394004370	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394004371	non-specific DNA binding site [nucleotide binding]; other site
1288394004372	salt bridge; other site
1288394004373	sequence-specific DNA binding site [nucleotide binding]; other site
1288394004374	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1288394004375	phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299
1288394004376	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1288394004377	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
1288394004378	PLD-like domain; Region: PLDc_2; pfam13091
1288394004379	homodimer interface [polypeptide binding]; other site
1288394004380	putative active site [active]
1288394004381	catalytic site [active]
1288394004382	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1288394004383	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
1288394004384	integrase; Provisional; Region: PRK09692
1288394004385	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1288394004386	active site
1288394004387	Int/Topo IB signature motif; other site
1288394004388	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1288394004389	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1288394004390	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1288394004391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394004392	dimer interface [polypeptide binding]; other site
1288394004393	conserved gate region; other site
1288394004394	putative PBP binding loops; other site
1288394004395	ABC-ATPase subunit interface; other site
1288394004396	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1288394004397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394004398	dimer interface [polypeptide binding]; other site
1288394004399	conserved gate region; other site
1288394004400	ABC-ATPase subunit interface; other site
1288394004401	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1288394004402	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394004403	Walker A/P-loop; other site
1288394004404	ATP binding site [chemical binding]; other site
1288394004405	Q-loop/lid; other site
1288394004406	ABC transporter signature motif; other site
1288394004407	Walker B; other site
1288394004408	D-loop; other site
1288394004409	H-loop/switch region; other site
1288394004410	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1288394004411	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394004412	Walker A/P-loop; other site
1288394004413	ATP binding site [chemical binding]; other site
1288394004414	Q-loop/lid; other site
1288394004415	ABC transporter signature motif; other site
1288394004416	Walker B; other site
1288394004417	D-loop; other site
1288394004418	H-loop/switch region; other site
1288394004419	lactaldehyde reductase; Region: lactal_redase; TIGR02638
1288394004420	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1288394004421	dimer interface [polypeptide binding]; other site
1288394004422	active site
1288394004423	metal binding site [ion binding]; metal-binding site
1288394004424	L-fucose mutarotase; Provisional; Region: fucU; PRK15420
1288394004425	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1288394004426	intersubunit interface [polypeptide binding]; other site
1288394004427	active site
1288394004428	Zn2+ binding site [ion binding]; other site
1288394004429	L-fuculokinase; Provisional; Region: PRK10331
1288394004430	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394004431	nucleotide binding site [chemical binding]; other site
1288394004432	L-fucose isomerase; Provisional; Region: fucI; PRK10991
1288394004433	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
1288394004434	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1288394004435	trimer interface [polypeptide binding]; other site
1288394004436	substrate binding site [chemical binding]; other site
1288394004437	Mn binding site [ion binding]; other site
1288394004438	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1288394004439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394004440	putative substrate translocation pore; other site
1288394004441	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1288394004442	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1288394004443	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1288394004444	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1288394004445	dimer interface [polypeptide binding]; other site
1288394004446	active site
1288394004447	heme binding site [chemical binding]; other site
1288394004448	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1288394004449	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1288394004450	Class I aldolases; Region: Aldolase_Class_I; cl17187
1288394004451	catalytic residue [active]
1288394004452	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1288394004453	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1288394004454	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1288394004455	putative active site [active]
1288394004456	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1288394004457	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1288394004458	putative active site cavity [active]
1288394004459	N-acetylmannosamine kinase; Provisional; Region: PRK05082
1288394004460	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394004461	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394004462	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
1288394004463	Na binding site [ion binding]; other site
1288394004464	Domain of unknown function (DUF386); Region: DUF386; cl01047
1288394004465	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1288394004466	Vibrio cholerae sialidase, lectin insertion; Region: Sial-lect-inser; pfam09264
1288394004467	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
1288394004468	Asp-box motif; other site
1288394004469	catalytic site [active]
1288394004470	Domain of unknown function (DUF927); Region: DUF927; pfam06048
1288394004471	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
1288394004472	integrase; Provisional; Region: PRK09692
1288394004473	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1288394004474	active site
1288394004475	Int/Topo IB signature motif; other site
1288394004476	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1288394004477	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1288394004478	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1288394004479	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1288394004480	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1288394004481	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1288394004482	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1288394004483	Hexamer interface [polypeptide binding]; other site
1288394004484	Hexagonal pore residue; other site
1288394004485	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1288394004486	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394004487	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1288394004488	Pyruvate formate lyase; Region: PFL; pfam02901
1288394004489	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
1288394004490	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1288394004491	dimer interface [polypeptide binding]; other site
1288394004492	active site
1288394004493	glycine loop; other site
1288394004494	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1288394004495	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
1288394004496	putative active site [active]
1288394004497	metal binding site [ion binding]; metal-binding site
1288394004498	Ethanolamine utilisation protein EutN/carboxysome; Region: EutN_CcmL; pfam03319
1288394004499	Hexamer/Pentamer interface [polypeptide binding]; other site
1288394004500	central pore; other site
1288394004501	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1288394004502	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1288394004503	putative catalytic cysteine [active]
1288394004504	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1288394004505	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1288394004506	Hexamer interface [polypeptide binding]; other site
1288394004507	Hexagonal pore residue; other site
1288394004508	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1288394004509	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1288394004510	Hexamer interface [polypeptide binding]; other site
1288394004511	Hexagonal pore residue; other site
1288394004512	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1288394004513	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
1288394004514	Hexamer interface [polypeptide binding]; other site
1288394004515	Hexagonal pore residue; other site
1288394004516	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1288394004517	DNA binding site [nucleotide binding]
1288394004518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394004519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394004520	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1288394004521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394004522	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394004523	dimerization interface [polypeptide binding]; other site
1288394004524	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
1288394004525	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1288394004526	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1288394004527	putative molybdopterin cofactor binding site [chemical binding]; other site
1288394004528	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1288394004529	putative molybdopterin cofactor binding site; other site
1288394004530	putative hydrolase; Validated; Region: PRK09248
1288394004531	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
1288394004532	active site
1288394004533	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394004534	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394004535	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
1288394004536	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1288394004537	active site
1288394004538	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1288394004539	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1288394004540	Protein export membrane protein; Region: SecD_SecF; cl14618
1288394004541	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1288394004542	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394004543	putative membrane fusion protein; Region: TIGR02828
1288394004544	pyruvate kinase; Provisional; Region: PRK05826
1288394004545	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1288394004546	domain interfaces; other site
1288394004547	active site
1288394004548	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
1288394004549	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1288394004550	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1288394004551	putative active site [active]
1288394004552	glucokinase; Provisional; Region: glk; PRK00292
1288394004553	glucokinase, proteobacterial type; Region: glk; TIGR00749
1288394004554	sensor protein PhoQ; Provisional; Region: PRK10815
1288394004555	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394004556	ATP binding site [chemical binding]; other site
1288394004557	Mg2+ binding site [ion binding]; other site
1288394004558	G-X-G motif; other site
1288394004559	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
1288394004560	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394004561	active site
1288394004562	phosphorylation site [posttranslational modification]
1288394004563	intermolecular recognition site; other site
1288394004564	dimerization interface [polypeptide binding]; other site
1288394004565	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394004566	DNA binding site [nucleotide binding]
1288394004567	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
1288394004568	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394004569	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394004570	Walker A/P-loop; other site
1288394004571	ATP binding site [chemical binding]; other site
1288394004572	Q-loop/lid; other site
1288394004573	ABC transporter signature motif; other site
1288394004574	Walker B; other site
1288394004575	D-loop; other site
1288394004576	H-loop/switch region; other site
1288394004577	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1288394004578	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394004579	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
1288394004580	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1288394004581	putative active site [active]
1288394004582	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394004583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394004584	Walker A/P-loop; other site
1288394004585	ATP binding site [chemical binding]; other site
1288394004586	Q-loop/lid; other site
1288394004587	ABC transporter signature motif; other site
1288394004588	Walker B; other site
1288394004589	D-loop; other site
1288394004590	H-loop/switch region; other site
1288394004591	RTX toxin acyltransferase family; Region: HlyC; pfam02794
1288394004592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394004593	Peptidase C80 family; Region: Peptidase_C80; pfam11713
1288394004594	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394004595	Coenzyme A binding pocket [chemical binding]; other site
1288394004596	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1288394004597	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1288394004598	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394004599	FeS/SAM binding site; other site
1288394004600	GAF domain; Region: GAF; cl17456
1288394004601	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394004602	Zn2+ binding site [ion binding]; other site
1288394004603	Mg2+ binding site [ion binding]; other site
1288394004604	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
1288394004605	putative amphipathic alpha helix; other site
1288394004606	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
1288394004607	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1288394004608	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1288394004609	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1288394004610	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1288394004611	MgtE intracellular N domain; Region: MgtE_N; smart00924
1288394004612	FliG C-terminal domain; Region: FliG_C; pfam01706
1288394004613	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
1288394004614	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1288394004615	Flagellar assembly protein FliH; Region: FliH; pfam02108
1288394004616	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972
1288394004617	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1288394004618	Walker A motif/ATP binding site; other site
1288394004619	Walker B motif; other site
1288394004620	Flagellar FliJ protein; Region: FliJ; pfam02050
1288394004621	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
1288394004622	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1288394004623	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
1288394004624	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1288394004625	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1288394004626	flagellar motor switch protein; Validated; Region: fliN; PRK08983
1288394004627	flagellar motor switch protein; Validated; Region: fliN; PRK05698
1288394004628	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
1288394004629	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1288394004630	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1288394004631	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1288394004632	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1288394004633	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1288394004634	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1288394004635	FHIPEP family; Region: FHIPEP; pfam00771
1288394004636	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1288394004637	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1288394004638	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1288394004639	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1288394004640	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1288394004641	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
1288394004642	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394004643	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1288394004644	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394004645	DNA binding residues [nucleotide binding]
1288394004646	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1288394004647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394004648	active site
1288394004649	phosphorylation site [posttranslational modification]
1288394004650	intermolecular recognition site; other site
1288394004651	dimerization interface [polypeptide binding]; other site
1288394004652	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
1288394004653	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394004654	putative binding surface; other site
1288394004655	active site
1288394004656	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1288394004657	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1288394004658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394004659	ATP binding site [chemical binding]; other site
1288394004660	Mg2+ binding site [ion binding]; other site
1288394004661	G-X-G motif; other site
1288394004662	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1288394004663	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1288394004664	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394004665	active site
1288394004666	phosphorylation site [posttranslational modification]
1288394004667	intermolecular recognition site; other site
1288394004668	dimerization interface [polypeptide binding]; other site
1288394004669	CheB methylesterase; Region: CheB_methylest; pfam01339
1288394004670	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1288394004671	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1288394004672	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1288394004673	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394004674	ligand binding site [chemical binding]; other site
1288394004675	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1288394004676	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1288394004677	P-loop; other site
1288394004678	Magnesium ion binding site [ion binding]; other site
1288394004679	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1288394004680	Magnesium ion binding site [ion binding]; other site
1288394004681	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1288394004682	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1288394004683	putative CheA interaction surface; other site
1288394004684	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
1288394004685	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
1288394004686	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
1288394004687	Walker A/P-loop; other site
1288394004688	ATP binding site [chemical binding]; other site
1288394004689	Q-loop/lid; other site
1288394004690	ABC transporter signature motif; other site
1288394004691	Walker B; other site
1288394004692	D-loop; other site
1288394004693	H-loop/switch region; other site
1288394004694	heme exporter protein CcmB; Region: ccmB; TIGR01190
1288394004695	heme exporter protein CcmC; Region: ccmC; TIGR01191
1288394004696	Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114
1288394004697	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
1288394004698	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1288394004699	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
1288394004700	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1288394004701	catalytic residues [active]
1288394004702	central insert; other site
1288394004703	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1288394004704	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1288394004705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394004706	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1288394004707	binding surface
1288394004708	TPR motif; other site
1288394004709	VacJ like lipoprotein; Region: VacJ; cl01073
1288394004710	superoxide dismutase; Provisional; Region: PRK10543
1288394004711	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1288394004712	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1288394004713	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1288394004714	putative GSH binding site [chemical binding]; other site
1288394004715	catalytic residues [active]
1288394004716	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1288394004717	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394004718	S-adenosylmethionine binding site [chemical binding]; other site
1288394004719	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
1288394004720	active site
1288394004721	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
1288394004722	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1288394004723	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1288394004724	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1288394004725	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1288394004726	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1288394004727	putative C-terminal domain interface [polypeptide binding]; other site
1288394004728	putative GSH binding site (G-site) [chemical binding]; other site
1288394004729	putative dimer interface [polypeptide binding]; other site
1288394004730	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1288394004731	N-terminal domain interface [polypeptide binding]; other site
1288394004732	dimer interface [polypeptide binding]; other site
1288394004733	substrate binding pocket (H-site) [chemical binding]; other site
1288394004734	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394004735	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394004736	Coenzyme A binding pocket [chemical binding]; other site
1288394004737	Uncharacterized conserved protein [Function unknown]; Region: COG2850
1288394004738	adenylosuccinate lyase; Provisional; Region: PRK09285
1288394004739	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
1288394004740	tetramer interface [polypeptide binding]; other site
1288394004741	active site
1288394004742	putative lysogenization regulator; Reviewed; Region: PRK00218
1288394004743	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1288394004744	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1288394004745	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
1288394004746	nudix motif; other site
1288394004747	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1288394004748	pseudouridine synthase; Region: TIGR00093
1288394004749	active site
1288394004750	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1288394004751	regulatory protein interface [polypeptide binding]; other site
1288394004752	active site
1288394004753	regulatory phosphorylation site [posttranslational modification]; other site
1288394004754	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394004755	active site
1288394004756	phosphorylation site [posttranslational modification]
1288394004757	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1288394004758	active site
1288394004759	P-loop; other site
1288394004760	phosphorylation site [posttranslational modification]
1288394004761	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
1288394004762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394004763	putative substrate translocation pore; other site
1288394004764	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
1288394004765	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394004766	active site
1288394004767	phosphorylation site [posttranslational modification]
1288394004768	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1288394004769	active site
1288394004770	P-loop; other site
1288394004771	phosphorylation site [posttranslational modification]
1288394004772	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1288394004773	topology modulation protein; Provisional; Region: PRK07261
1288394004774	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
1288394004775	active site
1288394004776	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1288394004777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394004778	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394004779	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394004780	Coenzyme A binding pocket [chemical binding]; other site
1288394004781	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394004782	Coenzyme A binding pocket [chemical binding]; other site
1288394004783	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1288394004784	Dimer interface [polypeptide binding]; other site
1288394004785	BRCT sequence motif; other site
1288394004786	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
1288394004787	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394004788	DNA binding site [nucleotide binding]
1288394004789	domain linker motif; other site
1288394004790	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1288394004791	bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110
1288394004792	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394004793	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394004794	active site turn [active]
1288394004795	phosphorylation site [posttranslational modification]
1288394004796	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1288394004797	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394004798	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394004799	homodimer interface [polypeptide binding]; other site
1288394004800	catalytic residue [active]
1288394004801	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394004802	active site
1288394004803	phosphorylation site [posttranslational modification]
1288394004804	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1288394004805	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1288394004806	active site
1288394004807	P-loop; other site
1288394004808	phosphorylation site [posttranslational modification]
1288394004809	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1288394004810	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1288394004811	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1288394004812	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394004813	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394004814	isocitrate dehydrogenase; Validated; Region: PRK07362
1288394004815	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1288394004816	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
1288394004817	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1288394004818	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394004819	catalytic residue [active]
1288394004820	permease DsdX; Provisional; Region: PRK09921
1288394004821	gluconate transporter; Region: gntP; TIGR00791
1288394004822	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
1288394004823	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394004824	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1288394004825	dimerization interface [polypeptide binding]; other site
1288394004826	substrate binding pocket [chemical binding]; other site
1288394004827	Abi-like protein; Region: Abi_2; cl01988
1288394004828	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1288394004829	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1288394004830	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1288394004831	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1288394004832	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1288394004833	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1288394004834	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1288394004835	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1288394004836	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
1288394004837	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394004838	ATP binding site [chemical binding]; other site
1288394004839	putative Mg++ binding site [ion binding]; other site
1288394004840	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394004841	sequence-specific DNA binding site [nucleotide binding]; other site
1288394004842	salt bridge; other site
1288394004843	Predicted transcriptional regulator [Transcription]; Region: COG2932
1288394004844	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1288394004845	Catalytic site [active]
1288394004846	Winged helix-turn helix; Region: HTH_29; pfam13551
1288394004847	Integrase core domain; Region: rve; pfam00665
1288394004848	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1288394004849	AAA ATPase domain; Region: AAA_16; pfam13191
1288394004850	AAA domain; Region: AAA_22; pfam13401
1288394004851	Protein of unknown function (DUF3164); Region: DUF3164; pfam11363
1288394004852	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
1288394004853	Uncharacterized conserved protein [Function unknown]; Region: COG5566
1288394004854	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1288394004855	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1288394004856	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
1288394004857	Protein of unknown function (DUF2730); Region: DUF2730; pfam10805
1288394004858	Protein of unknown function (DUF3486); Region: DUF3486; pfam11985
1288394004859	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
1288394004860	Protein of unknown function (DUF935); Region: DUF935; pfam06074
1288394004861	Mu-like prophage protein gp29 [Function unknown]; Region: COG4383
1288394004862	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1288394004863	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
1288394004864	Mu-like prophage I protein [General function prediction only]; Region: COG4388
1288394004865	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124
1288394004866	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1288394004867	Protein of unknown function (DUF1320); Region: DUF1320; cl01818
1288394004868	tape measure domain; Region: tape_meas_nterm; TIGR02675
1288394004869	potential frameshift: common BLAST hit: gi|330829495|ref|YP_004392447.1| curculin-like (mannose-binding) lectin protein
1288394004870	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
1288394004871	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1288394004872	SmpB-tmRNA interface; other site
1288394004873	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1288394004874	putative coenzyme Q binding site [chemical binding]; other site
1288394004875	hypothetical protein; Validated; Region: PRK01777
1288394004876	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1288394004877	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1288394004878	NAD binding site [chemical binding]; other site
1288394004879	active site
1288394004880	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1288394004881	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1288394004882	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
1288394004883	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1288394004884	Interdomain contacts; other site
1288394004885	Cytokine receptor motif; other site
1288394004886	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1288394004887	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1288394004888	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1288394004889	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1288394004890	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1288394004891	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
1288394004892	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1288394004893	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1288394004894	ATP binding site [chemical binding]; other site
1288394004895	Walker A motif; other site
1288394004896	hexamer interface [polypeptide binding]; other site
1288394004897	Walker B motif; other site
1288394004898	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1288394004899	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394004900	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1288394004901	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394004902	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
1288394004903	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1288394004904	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
1288394004905	metal ion-dependent adhesion site (MIDAS); other site
1288394004906	putative alcohol dehydrogenase; Provisional; Region: PRK09860
1288394004907	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1288394004908	dimer interface [polypeptide binding]; other site
1288394004909	active site
1288394004910	metal binding site [ion binding]; metal-binding site
1288394004911	uridine phosphorylase; Provisional; Region: PRK11178
1288394004912	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1288394004913	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1288394004914	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1288394004915	active site
1288394004916	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1288394004917	active site
1288394004918	tetramer interface [polypeptide binding]; other site
1288394004919	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
1288394004920	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
1288394004921	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394004922	dimerization interface [polypeptide binding]; other site
1288394004923	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394004924	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394004925	dimer interface [polypeptide binding]; other site
1288394004926	putative CheW interface [polypeptide binding]; other site
1288394004927	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394004928	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
1288394004929	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1288394004930	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
1288394004931	potassium/proton antiporter; Reviewed; Region: PRK05326
1288394004932	TrkA-C domain; Region: TrkA_C; pfam02080
1288394004933	Transporter associated domain; Region: CorC_HlyC; smart01091
1288394004934	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1288394004935	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1288394004936	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1288394004937	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1288394004938	metal binding site [ion binding]; metal-binding site
1288394004939	dimer interface [polypeptide binding]; other site
1288394004940	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
1288394004941	ArsC family; Region: ArsC; pfam03960
1288394004942	putative catalytic residues [active]
1288394004943	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394004944	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394004945	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394004946	substrate binding pocket [chemical binding]; other site
1288394004947	dimerization interface [polypeptide binding]; other site
1288394004948	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069
1288394004949	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1288394004950	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
1288394004951	hypothetical protein; Provisional; Region: PRK07338
1288394004952	metal binding site [ion binding]; metal-binding site
1288394004953	dimer interface [polypeptide binding]; other site
1288394004954	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
1288394004955	Ligand Binding Site [chemical binding]; other site
1288394004956	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
1288394004957	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
1288394004958	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1288394004959	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1288394004960	putative dimer interface [polypeptide binding]; other site
1288394004961	putative anticodon binding site; other site
1288394004962	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1288394004963	homodimer interface [polypeptide binding]; other site
1288394004964	motif 1; other site
1288394004965	motif 2; other site
1288394004966	active site
1288394004967	motif 3; other site
1288394004968	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394004969	dimerization interface [polypeptide binding]; other site
1288394004970	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394004971	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
1288394004972	inhibitor-cofactor binding pocket; inhibition site
1288394004973	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394004974	catalytic residue [active]
1288394004975	biotin synthase; Provisional; Region: PRK15108
1288394004976	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394004977	FeS/SAM binding site; other site
1288394004978	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1288394004979	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1288394004980	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1288394004981	substrate-cofactor binding pocket; other site
1288394004982	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394004983	catalytic residue [active]
1288394004984	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1288394004985	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394004986	S-adenosylmethionine binding site [chemical binding]; other site
1288394004987	AAA domain; Region: AAA_26; pfam13500
1288394004988	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1288394004989	heat shock protein HtpX; Provisional; Region: PRK05457
1288394004990	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394004991	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394004992	dimer interface [polypeptide binding]; other site
1288394004993	putative CheW interface [polypeptide binding]; other site
1288394004994	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1288394004995	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1288394004996	MOSC domain; Region: MOSC; pfam03473
1288394004997	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1288394004998	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1288394004999	FAD binding pocket [chemical binding]; other site
1288394005000	FAD binding motif [chemical binding]; other site
1288394005001	phosphate binding motif [ion binding]; other site
1288394005002	beta-alpha-beta structure motif; other site
1288394005003	NAD binding pocket [chemical binding]; other site
1288394005004	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394005005	catalytic loop [active]
1288394005006	iron binding site [ion binding]; other site
1288394005007	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
1288394005008	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394005009	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394005010	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394005011	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1288394005012	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1288394005013	dimer interface [polypeptide binding]; other site
1288394005014	PYR/PP interface [polypeptide binding]; other site
1288394005015	TPP binding site [chemical binding]; other site
1288394005016	substrate binding site [chemical binding]; other site
1288394005017	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1288394005018	Domain of unknown function; Region: EKR; smart00890
1288394005019	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394005020	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1288394005021	TPP-binding site [chemical binding]; other site
1288394005022	dimer interface [polypeptide binding]; other site
1288394005023	Penicillin amidase; Region: Penicil_amidase; pfam01804
1288394005024	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1288394005025	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
1288394005026	active site
1288394005027	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1288394005028	Helix-turn-helix domain; Region: HTH_18; pfam12833
1288394005029	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394005030	Protein of unknown function (DUF465); Region: DUF465; cl01070
1288394005031	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1288394005032	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1288394005033	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1288394005034	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1288394005035	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1288394005036	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1288394005037	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1288394005038	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1288394005039	cysteine synthase B; Region: cysM; TIGR01138
1288394005040	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1288394005041	dimer interface [polypeptide binding]; other site
1288394005042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394005043	catalytic residue [active]
1288394005044	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1288394005045	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1288394005046	active site
1288394005047	NAD binding site [chemical binding]; other site
1288394005048	metal binding site [ion binding]; metal-binding site
1288394005049	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1288394005050	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394005051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394005052	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1288394005053	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
1288394005054	NAD(P) binding site [chemical binding]; other site
1288394005055	catalytic residues [active]
1288394005056	NlpC/P60 family; Region: NLPC_P60; pfam00877
1288394005057	Hemolytic toxin N terminal; Region: Hemolysin_N; pfam12563
1288394005058	Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968
1288394005059	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1288394005060	Ricin-type beta-trefoil; Region: RICIN; smart00458
1288394005061	putative sugar binding sites [chemical binding]; other site
1288394005062	Q-X-W motif; other site
1288394005063	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1288394005064	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394005065	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1288394005066	dimerization interface [polypeptide binding]; other site
1288394005067	peroxidase; Provisional; Region: PRK15000
1288394005068	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1288394005069	dimer interface [polypeptide binding]; other site
1288394005070	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1288394005071	catalytic triad [active]
1288394005072	peroxidatic and resolving cysteines [active]
1288394005073	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
1288394005074	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
1288394005075	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
1288394005076	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1288394005077	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1288394005078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394005079	S-adenosylmethionine binding site [chemical binding]; other site
1288394005080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394005081	S-adenosylmethionine binding site [chemical binding]; other site
1288394005082	Protein of unknown function DUF72; Region: DUF72; cl00777
1288394005083	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1288394005084	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1288394005085	dimer interface [polypeptide binding]; other site
1288394005086	anticodon binding site; other site
1288394005087	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1288394005088	homodimer interface [polypeptide binding]; other site
1288394005089	motif 1; other site
1288394005090	active site
1288394005091	motif 2; other site
1288394005092	GAD domain; Region: GAD; pfam02938
1288394005093	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1288394005094	active site
1288394005095	motif 3; other site
1288394005096	hypothetical protein; Validated; Region: PRK00110
1288394005097	putative metal dependent hydrolase; Provisional; Region: PRK11598
1288394005098	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1288394005099	Sulfatase; Region: Sulfatase; pfam00884
1288394005100	putative metal dependent hydrolase; Provisional; Region: PRK11598
1288394005101	MarR family; Region: MarR_2; cl17246
1288394005102	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1288394005103	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1288394005104	nucleotide binding site [chemical binding]; other site
1288394005105	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1288394005106	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1288394005107	active site
1288394005108	dimer interface [polypeptide binding]; other site
1288394005109	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1288394005110	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1288394005111	active site
1288394005112	trimer interface [polypeptide binding]; other site
1288394005113	allosteric site; other site
1288394005114	active site lid [active]
1288394005115	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1288394005116	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1288394005117	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394005118	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394005119	active site turn [active]
1288394005120	phosphorylation site [posttranslational modification]
1288394005121	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
1288394005122	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
1288394005123	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
1288394005124	active site
1288394005125	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
1288394005126	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1288394005127	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1288394005128	active site
1288394005129	HIGH motif; other site
1288394005130	nucleotide binding site [chemical binding]; other site
1288394005131	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1288394005132	KMSKS motif; other site
1288394005133	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1288394005134	ferric uptake regulator; Provisional; Region: fur; PRK09462
1288394005135	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1288394005136	metal binding site 2 [ion binding]; metal-binding site
1288394005137	putative DNA binding helix; other site
1288394005138	metal binding site 1 [ion binding]; metal-binding site
1288394005139	dimer interface [polypeptide binding]; other site
1288394005140	structural Zn2+ binding site [ion binding]; other site
1288394005141	flavodoxin FldA; Validated; Region: PRK09267
1288394005142	LexA regulated protein; Provisional; Region: PRK11675
1288394005143	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
1288394005144	PGAP1-like protein; Region: PGAP1; pfam07819
1288394005145	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1288394005146	SeqA protein; Region: SeqA; pfam03925
1288394005147	phosphoglucomutase; Validated; Region: PRK07564
1288394005148	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1288394005149	active site
1288394005150	substrate binding site [chemical binding]; other site
1288394005151	metal binding site [ion binding]; metal-binding site
1288394005152	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1288394005153	EamA-like transporter family; Region: EamA; pfam00892
1288394005154	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1288394005155	MarR family; Region: MarR; pfam01047
1288394005156	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1288394005157	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394005158	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394005159	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1288394005160	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394005161	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
1288394005162	Walker A/P-loop; other site
1288394005163	ATP binding site [chemical binding]; other site
1288394005164	Q-loop/lid; other site
1288394005165	ABC transporter signature motif; other site
1288394005166	Walker B; other site
1288394005167	D-loop; other site
1288394005168	H-loop/switch region; other site
1288394005169	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
1288394005170	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394005171	putative PBP binding loops; other site
1288394005172	ABC-ATPase subunit interface; other site
1288394005173	hypothetical protein; Provisional; Region: PRK11622
1288394005174	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
1288394005175	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1288394005176	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1288394005177	mercuric reductase; Validated; Region: PRK06370
1288394005178	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394005179	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1288394005180	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1288394005181	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1288394005182	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
1288394005183	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1288394005184	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1288394005185	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1288394005186	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1288394005187	Surface antigen; Region: Bac_surface_Ag; pfam01103
1288394005188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1288394005189	Family of unknown function (DUF490); Region: DUF490; pfam04357
1288394005190	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
1288394005191	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1288394005192	30S subunit binding site; other site
1288394005193	GAF domain; Region: GAF; cl17456
1288394005194	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394005195	PAS domain; Region: PAS_9; pfam13426
1288394005196	putative active site [active]
1288394005197	heme pocket [chemical binding]; other site
1288394005198	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394005199	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394005200	metal binding site [ion binding]; metal-binding site
1288394005201	active site
1288394005202	I-site; other site
1288394005203	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394005204	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1288394005205	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394005206	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394005207	catalytic residue [active]
1288394005208	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1288394005209	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1288394005210	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1288394005211	dimerization interface (closed form) [polypeptide binding]; other site
1288394005212	ligand binding site [chemical binding]; other site
1288394005213	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1288394005214	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1288394005215	putative NAD(P) binding site [chemical binding]; other site
1288394005216	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1288394005217	hypothetical protein; Provisional; Region: PRK05421
1288394005218	putative catalytic site [active]
1288394005219	putative metal binding site [ion binding]; other site
1288394005220	putative phosphate binding site [ion binding]; other site
1288394005221	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
1288394005222	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394005223	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394005224	catalytic residue [active]
1288394005225	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394005226	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394005227	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394005228	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1288394005229	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1288394005230	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1288394005231	RNA/DNA hybrid binding site [nucleotide binding]; other site
1288394005232	active site
1288394005233	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1288394005234	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1288394005235	active site
1288394005236	catalytic site [active]
1288394005237	substrate binding site [chemical binding]; other site
1288394005238	TIGR03503 family protein; Region: TIGR03503
1288394005239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1288394005240	active site
1288394005241	phosphorylation site [posttranslational modification]
1288394005242	intermolecular recognition site; other site
1288394005243	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1288394005244	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
1288394005245	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394005246	Zn2+ binding site [ion binding]; other site
1288394005247	Mg2+ binding site [ion binding]; other site
1288394005248	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
1288394005249	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1288394005250	active site
1288394005251	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
1288394005252	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1288394005253	dimer interface [polypeptide binding]; other site
1288394005254	active site
1288394005255	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1288394005256	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1288394005257	putative active site [active]
1288394005258	putative dimer interface [polypeptide binding]; other site
1288394005259	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394005260	putative binding surface; other site
1288394005261	active site
1288394005262	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1288394005263	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1288394005264	phosphate binding site [ion binding]; other site
1288394005265	putative substrate binding pocket [chemical binding]; other site
1288394005266	dimer interface [polypeptide binding]; other site
1288394005267	FIST N domain; Region: FIST; pfam08495
1288394005268	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1288394005269	FIST C domain; Region: FIST_C; pfam10442
1288394005270	PAS domain; Region: PAS_9; pfam13426
1288394005271	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394005272	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394005273	dimer interface [polypeptide binding]; other site
1288394005274	phosphorylation site [posttranslational modification]
1288394005275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394005276	ATP binding site [chemical binding]; other site
1288394005277	Mg2+ binding site [ion binding]; other site
1288394005278	G-X-G motif; other site
1288394005279	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394005280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394005281	active site
1288394005282	phosphorylation site [posttranslational modification]
1288394005283	intermolecular recognition site; other site
1288394005284	dimerization interface [polypeptide binding]; other site
1288394005285	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
1288394005286	transcriptional regulator NarL; Provisional; Region: PRK10651
1288394005287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394005288	active site
1288394005289	phosphorylation site [posttranslational modification]
1288394005290	intermolecular recognition site; other site
1288394005291	dimerization interface [polypeptide binding]; other site
1288394005292	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394005293	DNA binding residues [nucleotide binding]
1288394005294	dimerization interface [polypeptide binding]; other site
1288394005295	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
1288394005296	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1288394005297	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394005298	dimerization interface [polypeptide binding]; other site
1288394005299	Histidine kinase; Region: HisKA_3; pfam07730
1288394005300	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394005301	ATP binding site [chemical binding]; other site
1288394005302	Mg2+ binding site [ion binding]; other site
1288394005303	G-X-G motif; other site
1288394005304	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1288394005305	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394005306	FeS/SAM binding site; other site
1288394005307	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1288394005308	ferredoxin-type protein; Provisional; Region: PRK10194
1288394005309	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394005310	NapD protein; Region: NapD; pfam03927
1288394005311	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
1288394005312	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1288394005313	[4Fe-4S] binding site [ion binding]; other site
1288394005314	molybdopterin cofactor binding site; other site
1288394005315	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1288394005316	molybdopterin cofactor binding site; other site
1288394005317	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
1288394005318	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
1288394005319	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1288394005320	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394005321	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
1288394005322	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
1288394005323	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
1288394005324	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1288394005325	MPT binding site; other site
1288394005326	trimer interface [polypeptide binding]; other site
1288394005327	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1288394005328	trimer interface [polypeptide binding]; other site
1288394005329	dimer interface [polypeptide binding]; other site
1288394005330	putative active site [active]
1288394005331	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1288394005332	MoaE interaction surface [polypeptide binding]; other site
1288394005333	MoeB interaction surface [polypeptide binding]; other site
1288394005334	thiocarboxylated glycine; other site
1288394005335	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1288394005336	MoaE homodimer interface [polypeptide binding]; other site
1288394005337	MoaD interaction [polypeptide binding]; other site
1288394005338	active site residues [active]
1288394005339	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1288394005340	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1288394005341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394005342	putative PBP binding loops; other site
1288394005343	dimer interface [polypeptide binding]; other site
1288394005344	ABC-ATPase subunit interface; other site
1288394005345	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
1288394005346	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394005347	Walker A/P-loop; other site
1288394005348	ATP binding site [chemical binding]; other site
1288394005349	Q-loop/lid; other site
1288394005350	ABC transporter signature motif; other site
1288394005351	Walker B; other site
1288394005352	D-loop; other site
1288394005353	H-loop/switch region; other site
1288394005354	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394005355	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1288394005356	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1288394005357	ATP binding site [chemical binding]; other site
1288394005358	substrate interface [chemical binding]; other site
1288394005359	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
1288394005360	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1288394005361	dimer interface [polypeptide binding]; other site
1288394005362	putative functional site; other site
1288394005363	putative MPT binding site; other site
1288394005364	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
1288394005365	GTP cyclohydrolase I; Provisional; Region: PLN03044
1288394005366	active site
1288394005367	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394005368	HAMP domain; Region: HAMP; pfam00672
1288394005369	dimerization interface [polypeptide binding]; other site
1288394005370	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394005371	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394005372	dimer interface [polypeptide binding]; other site
1288394005373	putative CheW interface [polypeptide binding]; other site
1288394005374	formate--tetrahydrofolate ligase; Provisional; Region: PRK13506
1288394005375	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1288394005376	Potassium binding sites [ion binding]; other site
1288394005377	Cesium cation binding sites [ion binding]; other site
1288394005378	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394005379	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394005380	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394005381	putative effector binding pocket; other site
1288394005382	dimerization interface [polypeptide binding]; other site
1288394005383	YceI-like domain; Region: YceI; cl01001
1288394005384	S-adenosyl-L-homocysteine hydrolase, NAD binding domain; Region: AdoHcyase_NAD; smart00997
1288394005385	NAD binding site [chemical binding]; other site
1288394005386	Rdx family; Region: Rdx; cl01407
1288394005387	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1288394005388	putative acyl-acceptor binding pocket; other site
1288394005389	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1288394005390	peptidase T; Region: peptidase-T; TIGR01882
1288394005391	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1288394005392	metal binding site [ion binding]; metal-binding site
1288394005393	dimer interface [polypeptide binding]; other site
1288394005394	arginine decarboxylase; Provisional; Region: PRK05354
1288394005395	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1288394005396	dimer interface [polypeptide binding]; other site
1288394005397	active site
1288394005398	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394005399	catalytic residues [active]
1288394005400	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1288394005401	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394005402	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394005403	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394005404	dimer interface [polypeptide binding]; other site
1288394005405	putative CheW interface [polypeptide binding]; other site
1288394005406	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
1288394005407	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1288394005408	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1288394005409	homotrimer interaction site [polypeptide binding]; other site
1288394005410	putative active site [active]
1288394005411	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1288394005412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1288394005413	YheO-like PAS domain; Region: PAS_6; pfam08348
1288394005414	HTH domain; Region: HTH_22; pfam13309
1288394005415	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1288394005416	catalytic core [active]
1288394005417	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
1288394005418	PLD-like domain; Region: PLDc_2; pfam13091
1288394005419	putative homodimer interface [polypeptide binding]; other site
1288394005420	putative active site [active]
1288394005421	catalytic site [active]
1288394005422	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1288394005423	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394005424	ATP binding site [chemical binding]; other site
1288394005425	putative Mg++ binding site [ion binding]; other site
1288394005426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394005427	nucleotide binding region [chemical binding]; other site
1288394005428	ATP-binding site [chemical binding]; other site
1288394005429	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1288394005430	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
1288394005431	dimer interface [polypeptide binding]; other site
1288394005432	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394005433	metal binding site [ion binding]; metal-binding site
1288394005434	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
1288394005435	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1288394005436	glutamate dehydrogenase; Provisional; Region: PRK09414
1288394005437	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1288394005438	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1288394005439	NAD(P) binding site [chemical binding]; other site
1288394005440	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1288394005441	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394005442	RNA binding surface [nucleotide binding]; other site
1288394005443	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1288394005444	probable active site [active]
1288394005445	putative cyanate transporter; Provisional; Region: cynX; PRK09705
1288394005446	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005447	putative substrate translocation pore; other site
1288394005448	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1288394005449	nucleoside/Zn binding site; other site
1288394005450	dimer interface [polypeptide binding]; other site
1288394005451	catalytic motif [active]
1288394005452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394005453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394005454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394005455	dimerization interface [polypeptide binding]; other site
1288394005456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005457	putative substrate translocation pore; other site
1288394005458	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1288394005459	hypothetical protein; Provisional; Region: PRK11038
1288394005460	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1288394005461	Protein of unknown function (DUF533); Region: DUF533; pfam04391
1288394005462	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
1288394005463	putative metal binding site [ion binding]; other site
1288394005464	putative acetyltransferase; Provisional; Region: PRK03624
1288394005465	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394005466	Coenzyme A binding pocket [chemical binding]; other site
1288394005467	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1288394005468	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394005469	DNA-binding site [nucleotide binding]; DNA binding site
1288394005470	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394005471	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394005472	homodimer interface [polypeptide binding]; other site
1288394005473	catalytic residue [active]
1288394005474	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1288394005475	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1288394005476	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1288394005477	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1288394005478	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
1288394005479	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1288394005480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005481	putative substrate translocation pore; other site
1288394005482	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1288394005483	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1288394005484	active site
1288394005485	catalytic tetrad [active]
1288394005486	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1288394005487	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1288394005488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394005489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394005490	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394005491	dimerization interface [polypeptide binding]; other site
1288394005492	glycerol kinase; Provisional; Region: glpK; PRK00047
1288394005493	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1288394005494	N- and C-terminal domain interface [polypeptide binding]; other site
1288394005495	active site
1288394005496	MgATP binding site [chemical binding]; other site
1288394005497	catalytic site [active]
1288394005498	metal binding site [ion binding]; metal-binding site
1288394005499	glycerol binding site [chemical binding]; other site
1288394005500	homotetramer interface [polypeptide binding]; other site
1288394005501	homodimer interface [polypeptide binding]; other site
1288394005502	FBP binding site [chemical binding]; other site
1288394005503	protein IIAGlc interface [polypeptide binding]; other site
1288394005504	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1288394005505	amphipathic channel; other site
1288394005506	Asn-Pro-Ala signature motifs; other site
1288394005507	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
1288394005508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005509	putative substrate translocation pore; other site
1288394005510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005511	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
1288394005512	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1288394005513	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1288394005514	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1288394005515	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1288394005516	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
1288394005517	active site
1288394005518	catalytic site [active]
1288394005519	metal binding site [ion binding]; metal-binding site
1288394005520	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
1288394005521	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1288394005522	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
1288394005523	Chorismate mutase type II; Region: CM_2; cl00693
1288394005524	prephenate dehydrogenase; Provisional; Region: PRK06444
1288394005525	prephenate dehydrogenase; Validated; Region: PRK08507
1288394005526	transcriptional regulator HdfR; Provisional; Region: PRK03601
1288394005527	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394005528	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1288394005529	hypothetical protein; Provisional; Region: PRK11027
1288394005530	Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cl00178
1288394005531	secondary substrate binding site; other site
1288394005532	primary substrate binding site; other site
1288394005533	inhibition loop; other site
1288394005534	dimerization interface [polypeptide binding]; other site
1288394005535	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
1288394005536	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
1288394005537	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
1288394005538	Zn binding site [ion binding]; other site
1288394005539	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
1288394005540	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1288394005541	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1288394005542	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1288394005543	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394005544	N-terminal plug; other site
1288394005545	ligand-binding site [chemical binding]; other site
1288394005546	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
1288394005547	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
1288394005548	Sulfatase; Region: Sulfatase; cl17466
1288394005549	hypothetical protein; Provisional; Region: PRK13689
1288394005550	Nucleoid-associated protein [General function prediction only]; Region: COG3081
1288394005551	nucleoid-associated protein NdpA; Validated; Region: PRK00378
1288394005552	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
1288394005553	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1288394005554	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394005555	dimer interface [polypeptide binding]; other site
1288394005556	conserved gate region; other site
1288394005557	putative PBP binding loops; other site
1288394005558	ABC-ATPase subunit interface; other site
1288394005559	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1288394005560	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394005561	dimer interface [polypeptide binding]; other site
1288394005562	conserved gate region; other site
1288394005563	putative PBP binding loops; other site
1288394005564	ABC-ATPase subunit interface; other site
1288394005565	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
1288394005566	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1288394005567	Walker A/P-loop; other site
1288394005568	ATP binding site [chemical binding]; other site
1288394005569	Q-loop/lid; other site
1288394005570	ABC transporter signature motif; other site
1288394005571	Walker B; other site
1288394005572	D-loop; other site
1288394005573	H-loop/switch region; other site
1288394005574	TOBE domain; Region: TOBE; pfam03459
1288394005575	TOBE domain; Region: TOBE_2; pfam08402
1288394005576	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1288394005577	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1288394005578	MltA-interacting protein MipA; Region: MipA; cl01504
1288394005579	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1288394005580	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1288394005581	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1288394005582	CPxP  motif; other site
1288394005583	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1288394005584	Peptidase family M48; Region: Peptidase_M48; pfam01435
1288394005585	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1288394005586	binding surface
1288394005587	TPR motif; other site
1288394005588	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1288394005589	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1288394005590	catalytic residues [active]
1288394005591	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1288394005592	ArsC family; Region: ArsC; pfam03960
1288394005593	catalytic residues [active]
1288394005594	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
1288394005595	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
1288394005596	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1288394005597	Protein of unknown function, DUF479; Region: DUF479; cl01203
1288394005598	isoaspartyl dipeptidase; Provisional; Region: PRK10657
1288394005599	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1288394005600	active site
1288394005601	Predicted membrane protein [Function unknown]; Region: COG2431
1288394005602	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1288394005603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394005604	Walker A/P-loop; other site
1288394005605	ATP binding site [chemical binding]; other site
1288394005606	Q-loop/lid; other site
1288394005607	ABC transporter signature motif; other site
1288394005608	Walker B; other site
1288394005609	D-loop; other site
1288394005610	H-loop/switch region; other site
1288394005611	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1288394005612	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394005613	substrate binding pocket [chemical binding]; other site
1288394005614	membrane-bound complex binding site; other site
1288394005615	hinge residues; other site
1288394005616	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394005617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394005618	dimer interface [polypeptide binding]; other site
1288394005619	conserved gate region; other site
1288394005620	putative PBP binding loops; other site
1288394005621	ABC-ATPase subunit interface; other site
1288394005622	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394005623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394005624	dimer interface [polypeptide binding]; other site
1288394005625	conserved gate region; other site
1288394005626	putative PBP binding loops; other site
1288394005627	ABC-ATPase subunit interface; other site
1288394005628	Predicted membrane protein [Function unknown]; Region: COG3235
1288394005629	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1288394005630	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
1288394005631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394005632	FeS/SAM binding site; other site
1288394005633	GAF domain; Region: GAF; pfam01590
1288394005634	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394005635	PAS domain; Region: PAS_9; pfam13426
1288394005636	putative active site [active]
1288394005637	heme pocket [chemical binding]; other site
1288394005638	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394005639	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394005640	metal binding site [ion binding]; metal-binding site
1288394005641	active site
1288394005642	I-site; other site
1288394005643	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394005644	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
1288394005645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394005646	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394005647	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1288394005648	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
1288394005649	active site residue [active]
1288394005650	HlyD family secretion protein; Region: HlyD; pfam00529
1288394005651	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394005652	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394005653	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1288394005654	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1288394005655	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1288394005656	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
1288394005657	metal binding site [ion binding]; metal-binding site
1288394005658	putative dimer interface [polypeptide binding]; other site
1288394005659	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1288394005660	MG2 domain; Region: A2M_N; pfam01835
1288394005661	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1288394005662	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1288394005663	surface patch; other site
1288394005664	thioester region; other site
1288394005665	penicillin-binding protein 1C; Provisional; Region: PRK11240
1288394005666	Transglycosylase; Region: Transgly; pfam00912
1288394005667	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1288394005668	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1288394005669	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
1288394005670	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1288394005671	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1288394005672	Ligand Binding Site [chemical binding]; other site
1288394005673	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1288394005674	active site residue [active]
1288394005675	Predicted membrane protein [Function unknown]; Region: COG2860
1288394005676	UPF0126 domain; Region: UPF0126; pfam03458
1288394005677	UPF0126 domain; Region: UPF0126; pfam03458
1288394005678	flagellin; Provisional; Region: PRK12804
1288394005679	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1288394005680	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1288394005681	flagellin; Provisional; Region: PRK12802
1288394005682	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1288394005683	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1288394005684	Integrase core domain; Region: rve; pfam00665
1288394005685	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1288394005686	Integrase core domain; Region: rve_3; pfam13683
1288394005687	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1288394005688	Transposase; Region: HTH_Tnp_1; pfam01527
1288394005689	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1288394005690	flagellin; Provisional; Region: PRK12804
1288394005691	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1288394005692	FlaG protein; Region: FlaG; pfam03646
1288394005693	flagellar capping protein; Reviewed; Region: fliD; PRK08032
1288394005694	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1288394005695	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
1288394005696	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1288394005697	Flagellar protein FliS; Region: FliS; cl00654
1288394005698	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394005699	S-adenosylmethionine binding site [chemical binding]; other site
1288394005700	pseudaminic acid synthase; Region: PseI; TIGR03586
1288394005701	NeuB family; Region: NeuB; pfam03102
1288394005702	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
1288394005703	NeuB binding interface [polypeptide binding]; other site
1288394005704	putative substrate binding site [chemical binding]; other site
1288394005705	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
1288394005706	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394005707	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394005708	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1288394005709	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
1288394005710	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394005711	inhibitor-cofactor binding pocket; inhibition site
1288394005712	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394005713	catalytic residue [active]
1288394005714	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
1288394005715	ligand binding site; other site
1288394005716	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1288394005717	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1288394005718	active site
1288394005719	catalytic tetrad [active]
1288394005720	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1288394005721	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1288394005722	inhibitor-cofactor binding pocket; inhibition site
1288394005723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394005724	catalytic residue [active]
1288394005725	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
1288394005726	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1288394005727	NAD(P) binding site [chemical binding]; other site
1288394005728	homodimer interface [polypeptide binding]; other site
1288394005729	substrate binding site [chemical binding]; other site
1288394005730	active site
1288394005731	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
1288394005732	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
1288394005733	cobalamin binding residues [chemical binding]; other site
1288394005734	putative BtuC binding residues; other site
1288394005735	dimer interface [polypeptide binding]; other site
1288394005736	CobD/Cbib protein; Region: CobD_Cbib; cl00561
1288394005737	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1288394005738	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1288394005739	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394005740	substrate binding pocket [chemical binding]; other site
1288394005741	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394005742	membrane-bound complex binding site; other site
1288394005743	hinge residues; other site
1288394005744	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1288394005745	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394005746	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394005747	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394005748	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394005749	dimer interface [polypeptide binding]; other site
1288394005750	putative CheW interface [polypeptide binding]; other site
1288394005751	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1288394005752	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1288394005753	active site
1288394005754	dimerization interface [polypeptide binding]; other site
1288394005755	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
1288394005756	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1288394005757	C-terminal domain interface [polypeptide binding]; other site
1288394005758	GSH binding site (G-site) [chemical binding]; other site
1288394005759	dimer interface [polypeptide binding]; other site
1288394005760	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1288394005761	N-terminal domain interface [polypeptide binding]; other site
1288394005762	dimer interface [polypeptide binding]; other site
1288394005763	substrate binding pocket (H-site) [chemical binding]; other site
1288394005764	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
1288394005765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005766	putative substrate translocation pore; other site
1288394005767	Cell division protein ZapA; Region: ZapA; cl01146
1288394005768	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
1288394005769	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
1288394005770	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
1288394005771	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1288394005772	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
1288394005773	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1288394005774	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1288394005775	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1288394005776	lipoyl attachment site [posttranslational modification]; other site
1288394005777	glycine dehydrogenase; Provisional; Region: PRK05367
1288394005778	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1288394005779	tetramer interface [polypeptide binding]; other site
1288394005780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394005781	catalytic residue [active]
1288394005782	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1288394005783	tetramer interface [polypeptide binding]; other site
1288394005784	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394005785	catalytic residue [active]
1288394005786	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394005787	dimerization interface [polypeptide binding]; other site
1288394005788	putative DNA binding site [nucleotide binding]; other site
1288394005789	putative Zn2+ binding site [ion binding]; other site
1288394005790	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1288394005791	arsenical-resistance protein; Region: acr3; TIGR00832
1288394005792	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1288394005793	ArsC family; Region: ArsC; pfam03960
1288394005794	catalytic residues [active]
1288394005795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394005796	S-adenosylmethionine binding site [chemical binding]; other site
1288394005797	putative MFS family transporter protein; Provisional; Region: PRK03633
1288394005798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394005799	putative substrate translocation pore; other site
1288394005800	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
1288394005801	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
1288394005802	catalytic residue [active]
1288394005803	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
1288394005804	catalytic residues [active]
1288394005805	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394005806	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394005807	peroxiredoxin; Region: AhpC; TIGR03137
1288394005808	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1288394005809	dimer interface [polypeptide binding]; other site
1288394005810	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1288394005811	catalytic triad [active]
1288394005812	peroxidatic and resolving cysteines [active]
1288394005813	FOG: CBS domain [General function prediction only]; Region: COG0517
1288394005814	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1288394005815	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1288394005816	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1288394005817	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1288394005818	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1288394005819	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
1288394005820	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933
1288394005821	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
1288394005822	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1288394005823	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1288394005824	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1288394005825	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1288394005826	Protein export membrane protein; Region: SecD_SecF; pfam02355
1288394005827	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1288394005828	active site residue [active]
1288394005829	TPR repeat; Region: TPR_11; pfam13414
1288394005830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394005831	binding surface
1288394005832	TPR motif; other site
1288394005833	TPR repeat; Region: TPR_11; pfam13414
1288394005834	putative protease; Provisional; Region: PRK15447
1288394005835	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1288394005836	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1288394005837	Peptidase family U32; Region: Peptidase_U32; pfam01136
1288394005838	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
1288394005839	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
1288394005840	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1288394005841	Transcriptional regulator; Region: Rrf2; cl17282
1288394005842	Rrf2 family protein; Region: rrf2_super; TIGR00738
1288394005843	cysteine desulfurase; Provisional; Region: PRK14012
1288394005844	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1288394005845	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394005846	catalytic residue [active]
1288394005847	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1288394005848	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1288394005849	trimerization site [polypeptide binding]; other site
1288394005850	active site
1288394005851	iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011
1288394005852	co-chaperone HscB; Provisional; Region: hscB; PRK05014
1288394005853	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1288394005854	HSP70 interaction site [polypeptide binding]; other site
1288394005855	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
1288394005856	chaperone protein HscA; Provisional; Region: hscA; PRK05183
1288394005857	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
1288394005858	nucleotide binding site [chemical binding]; other site
1288394005859	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1288394005860	SBD interface [polypeptide binding]; other site
1288394005861	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1288394005862	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394005863	catalytic loop [active]
1288394005864	iron binding site [ion binding]; other site
1288394005865	aminopeptidase B; Provisional; Region: PRK05015
1288394005866	Peptidase; Region: DUF3663; pfam12404
1288394005867	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294
1288394005868	interface (dimer of trimers) [polypeptide binding]; other site
1288394005869	Substrate-binding/catalytic site; other site
1288394005870	Zn-binding sites [ion binding]; other site
1288394005871	aminopeptidase B; Provisional; Region: PRK05015
1288394005872	Peptidase; Region: DUF3663; pfam12404
1288394005873	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1288394005874	interface (dimer of trimers) [polypeptide binding]; other site
1288394005875	Substrate-binding/catalytic site; other site
1288394005876	Zn-binding sites [ion binding]; other site
1288394005877	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1288394005878	active site
1288394005879	multimer interface [polypeptide binding]; other site
1288394005880	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
1288394005881	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394005882	FeS/SAM binding site; other site
1288394005883	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1288394005884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394005885	binding surface
1288394005886	TPR motif; other site
1288394005887	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394005888	non-specific DNA binding site [nucleotide binding]; other site
1288394005889	salt bridge; other site
1288394005890	sequence-specific DNA binding site [nucleotide binding]; other site
1288394005891	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1288394005892	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1288394005893	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1288394005894	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1288394005895	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1288394005896	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1288394005897	dimer interface [polypeptide binding]; other site
1288394005898	motif 1; other site
1288394005899	active site
1288394005900	motif 2; other site
1288394005901	motif 3; other site
1288394005902	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1288394005903	anticodon binding site; other site
1288394005904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
1288394005905	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
1288394005906	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
1288394005907	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1288394005908	Trp docking motif [polypeptide binding]; other site
1288394005909	active site
1288394005910	GTP-binding protein Der; Reviewed; Region: PRK00093
1288394005911	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1288394005912	G1 box; other site
1288394005913	GTP/Mg2+ binding site [chemical binding]; other site
1288394005914	Switch I region; other site
1288394005915	G2 box; other site
1288394005916	Switch II region; other site
1288394005917	G3 box; other site
1288394005918	G4 box; other site
1288394005919	G5 box; other site
1288394005920	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1288394005921	G1 box; other site
1288394005922	GTP/Mg2+ binding site [chemical binding]; other site
1288394005923	Switch I region; other site
1288394005924	G2 box; other site
1288394005925	G3 box; other site
1288394005926	Switch II region; other site
1288394005927	G4 box; other site
1288394005928	G5 box; other site
1288394005929	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
1288394005930	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
1288394005931	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394005932	substrate binding pocket [chemical binding]; other site
1288394005933	membrane-bound complex binding site; other site
1288394005934	hinge residues; other site
1288394005935	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394005936	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394005937	catalytic residue [active]
1288394005938	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1288394005939	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1288394005940	dimerization interface [polypeptide binding]; other site
1288394005941	ATP binding site [chemical binding]; other site
1288394005942	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1288394005943	dimerization interface [polypeptide binding]; other site
1288394005944	ATP binding site [chemical binding]; other site
1288394005945	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1288394005946	putative active site [active]
1288394005947	catalytic triad [active]
1288394005948	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
1288394005949	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1288394005950	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1288394005951	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1288394005952	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1288394005953	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1288394005954	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1288394005955	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1288394005956	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1288394005957	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1288394005958	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1288394005959	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1288394005960	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394005961	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394005962	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1288394005963	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1288394005964	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394005965	NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973
1288394005966	catalytic loop [active]
1288394005967	iron binding site [ion binding]; other site
1288394005968	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
1288394005969	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
1288394005970	[4Fe-4S] binding site [ion binding]; other site
1288394005971	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1288394005972	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
1288394005973	SLBB domain; Region: SLBB; pfam10531
1288394005974	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1288394005975	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1288394005976	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1288394005977	putative dimer interface [polypeptide binding]; other site
1288394005978	[2Fe-2S] cluster binding site [ion binding]; other site
1288394005979	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
1288394005980	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1288394005981	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1288394005982	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1288394005983	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1288394005984	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
1288394005985	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1288394005986	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394005987	ligand binding site [chemical binding]; other site
1288394005988	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1288394005989	flagellar motor protein MotP; Reviewed; Region: PRK06743
1288394005990	Repair protein; Region: Repair_PSII; cl01535
1288394005991	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
1288394005992	Repair protein; Region: Repair_PSII; pfam04536
1288394005993	LemA family; Region: LemA; pfam04011
1288394005994	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1288394005995	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1288394005996	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1288394005997	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1288394005998	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1288394005999	active site
1288394006000	catalytic tetrad [active]
1288394006001	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1288394006002	sequence-specific DNA binding site [nucleotide binding]; other site
1288394006003	salt bridge; other site
1288394006004	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1288394006005	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394006006	NAD(P) binding site [chemical binding]; other site
1288394006007	active site
1288394006008	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1288394006009	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
1288394006010	tetramer interface [polypeptide binding]; other site
1288394006011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394006012	catalytic residue [active]
1288394006013	PAS domain; Region: PAS; smart00091
1288394006014	PAS fold; Region: PAS_4; pfam08448
1288394006015	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394006016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394006017	active site
1288394006018	phosphorylation site [posttranslational modification]
1288394006019	intermolecular recognition site; other site
1288394006020	dimerization interface [polypeptide binding]; other site
1288394006021	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1288394006022	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394006023	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006024	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394006025	putative effector binding pocket; other site
1288394006026	dimerization interface [polypeptide binding]; other site
1288394006027	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
1288394006028	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394006029	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394006030	metal binding site [ion binding]; metal-binding site
1288394006031	active site
1288394006032	I-site; other site
1288394006033	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394006034	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1288394006035	dimer interface [polypeptide binding]; other site
1288394006036	FMN binding site [chemical binding]; other site
1288394006037	NADPH bind site [chemical binding]; other site
1288394006038	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1288394006039	active site
1288394006040	metal binding site [ion binding]; metal-binding site
1288394006041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394006042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394006043	putative substrate translocation pore; other site
1288394006044	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394006045	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006046	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394006047	dimerization interface [polypeptide binding]; other site
1288394006048	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
1288394006049	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006050	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
1288394006051	substrate binding site [chemical binding]; other site
1288394006052	dimerization interface [polypeptide binding]; other site
1288394006053	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1288394006054	dimerization interface [polypeptide binding]; other site
1288394006055	active site
1288394006056	cytidylate kinase; Provisional; Region: cmk; PRK00023
1288394006057	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1288394006058	CMP-binding site; other site
1288394006059	The sites determining sugar specificity; other site
1288394006060	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1288394006061	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1288394006062	RNA binding site [nucleotide binding]; other site
1288394006063	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1288394006064	RNA binding site [nucleotide binding]; other site
1288394006065	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1288394006066	RNA binding site [nucleotide binding]; other site
1288394006067	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1288394006068	RNA binding site [nucleotide binding]; other site
1288394006069	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1288394006070	RNA binding site [nucleotide binding]; other site
1288394006071	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
1288394006072	RNA binding site [nucleotide binding]; other site
1288394006073	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1288394006074	IHF dimer interface [polypeptide binding]; other site
1288394006075	IHF - DNA interface [nucleotide binding]; other site
1288394006076	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1288394006077	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1288394006078	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1288394006079	TPR motif; other site
1288394006080	binding surface
1288394006081	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394006082	binding surface
1288394006083	TPR motif; other site
1288394006084	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1288394006085	active site
1288394006086	dimer interface [polypeptide binding]; other site
1288394006087	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
1288394006088	DTW domain; Region: DTW; cl01221
1288394006089	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1288394006090	Ligand Binding Site [chemical binding]; other site
1288394006091	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1288394006092	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1288394006093	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
1288394006094	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1288394006095	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
1288394006096	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1288394006097	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1288394006098	thymidine kinase; Provisional; Region: PRK04296
1288394006099	Domain of unknown function (DUF1704); Region: DUF1704; pfam08014
1288394006100	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1288394006101	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
1288394006102	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
1288394006103	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
1288394006104	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1288394006105	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
1288394006106	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1288394006107	catalytic residue [active]
1288394006108	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
1288394006109	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1288394006110	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1288394006111	homodimer interface [polypeptide binding]; other site
1288394006112	NADP binding site [chemical binding]; other site
1288394006113	substrate binding site [chemical binding]; other site
1288394006114	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1288394006115	DNA-binding site [nucleotide binding]; DNA binding site
1288394006116	RNA-binding motif; other site
1288394006117	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1288394006118	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
1288394006119	Clp amino terminal domain; Region: Clp_N; pfam02861
1288394006120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394006121	Walker A motif; other site
1288394006122	ATP binding site [chemical binding]; other site
1288394006123	Walker B motif; other site
1288394006124	arginine finger; other site
1288394006125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394006126	Walker A motif; other site
1288394006127	ATP binding site [chemical binding]; other site
1288394006128	Walker B motif; other site
1288394006129	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1288394006130	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1288394006131	rRNA binding site [nucleotide binding]; other site
1288394006132	predicted 30S ribosome binding site; other site
1288394006133	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1288394006134	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1288394006135	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1288394006136	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1288394006137	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394006138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394006139	active site
1288394006140	phosphorylation site [posttranslational modification]
1288394006141	intermolecular recognition site; other site
1288394006142	dimerization interface [polypeptide binding]; other site
1288394006143	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394006144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394006145	active site
1288394006146	phosphorylation site [posttranslational modification]
1288394006147	intermolecular recognition site; other site
1288394006148	dimerization interface [polypeptide binding]; other site
1288394006149	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394006150	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394006151	metal binding site [ion binding]; metal-binding site
1288394006152	active site
1288394006153	I-site; other site
1288394006154	thioredoxin reductase; Provisional; Region: PRK10262
1288394006155	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394006156	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394006157	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1288394006158	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394006159	putative DNA binding site [nucleotide binding]; other site
1288394006160	putative Zn2+ binding site [ion binding]; other site
1288394006161	AsnC family; Region: AsnC_trans_reg; pfam01037
1288394006162	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1288394006163	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1288394006164	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1288394006165	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1288394006166	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1288394006167	recombination factor protein RarA; Reviewed; Region: PRK13342
1288394006168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394006169	Walker A motif; other site
1288394006170	ATP binding site [chemical binding]; other site
1288394006171	Walker B motif; other site
1288394006172	arginine finger; other site
1288394006173	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1288394006174	seryl-tRNA synthetase; Provisional; Region: PRK05431
1288394006175	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1288394006176	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1288394006177	dimer interface [polypeptide binding]; other site
1288394006178	active site
1288394006179	motif 1; other site
1288394006180	motif 2; other site
1288394006181	motif 3; other site
1288394006182	Colicin V production protein; Region: Colicin_V; cl00567
1288394006183	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1288394006184	amidophosphoribosyltransferase; Provisional; Region: PRK09246
1288394006185	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1288394006186	active site
1288394006187	tetramer interface [polypeptide binding]; other site
1288394006188	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394006189	active site
1288394006190	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1288394006191	active site
1288394006192	dinuclear metal binding site [ion binding]; other site
1288394006193	dimerization interface [polypeptide binding]; other site
1288394006194	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
1288394006195	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394006196	Walker A/P-loop; other site
1288394006197	ATP binding site [chemical binding]; other site
1288394006198	Q-loop/lid; other site
1288394006199	ABC transporter signature motif; other site
1288394006200	Walker B; other site
1288394006201	D-loop; other site
1288394006202	H-loop/switch region; other site
1288394006203	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
1288394006204	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394006205	Walker A/P-loop; other site
1288394006206	ATP binding site [chemical binding]; other site
1288394006207	Q-loop/lid; other site
1288394006208	ABC transporter signature motif; other site
1288394006209	Walker B; other site
1288394006210	D-loop; other site
1288394006211	H-loop/switch region; other site
1288394006212	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1288394006213	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
1288394006214	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1288394006215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394006216	dimer interface [polypeptide binding]; other site
1288394006217	conserved gate region; other site
1288394006218	putative PBP binding loops; other site
1288394006219	ABC-ATPase subunit interface; other site
1288394006220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394006221	dimer interface [polypeptide binding]; other site
1288394006222	conserved gate region; other site
1288394006223	putative PBP binding loops; other site
1288394006224	ABC-ATPase subunit interface; other site
1288394006225	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
1288394006226	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1288394006227	peptide binding site [polypeptide binding]; other site
1288394006228	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1288394006229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394006230	Walker A motif; other site
1288394006231	ATP binding site [chemical binding]; other site
1288394006232	Walker B motif; other site
1288394006233	arginine finger; other site
1288394006234	phage shock protein A; Region: phageshock_pspA; TIGR02977
1288394006235	phage shock protein B; Provisional; Region: pspB; PRK09458
1288394006236	PspC domain; Region: PspC; cl00864
1288394006237	phage shock protein C; Region: phageshock_pspC; TIGR02978
1288394006238	YcjX-like family, DUF463; Region: DUF463; pfam04317
1288394006239	hypothetical protein; Provisional; Region: PRK05415
1288394006240	Domain of unknown function (DUF697); Region: DUF697; cl12064
1288394006241	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
1288394006242	cofactor binding site; other site
1288394006243	metal binding site [ion binding]; metal-binding site
1288394006244	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
1288394006245	aromatic arch; other site
1288394006246	DCoH dimer interaction site [polypeptide binding]; other site
1288394006247	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1288394006248	DCoH tetramer interaction site [polypeptide binding]; other site
1288394006249	substrate binding site [chemical binding]; other site
1288394006250	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
1288394006251	substrate binding site [chemical binding]; other site
1288394006252	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
1288394006253	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
1288394006254	putative aromatic amino acid binding site; other site
1288394006255	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394006256	putative active site [active]
1288394006257	heme pocket [chemical binding]; other site
1288394006258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394006259	Walker A motif; other site
1288394006260	ATP binding site [chemical binding]; other site
1288394006261	Walker B motif; other site
1288394006262	arginine finger; other site
1288394006263	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
1288394006264	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
1288394006265	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394006266	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394006267	metal binding site [ion binding]; metal-binding site
1288394006268	active site
1288394006269	I-site; other site
1288394006270	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394006271	ligand binding site [chemical binding]; other site
1288394006272	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1288394006273	Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199
1288394006274	YfcL protein; Region: YfcL; pfam08891
1288394006275	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1288394006276	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
1288394006277	acyl-activating enzyme (AAE) consensus motif; other site
1288394006278	putative AMP binding site [chemical binding]; other site
1288394006279	putative active site [active]
1288394006280	putative CoA binding site [chemical binding]; other site
1288394006281	cytidine deaminase; Provisional; Region: PRK09027
1288394006282	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1288394006283	active site
1288394006284	catalytic motif [active]
1288394006285	Zn binding site [ion binding]; other site
1288394006286	Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211
1288394006287	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1288394006288	LrgA family; Region: LrgA; cl00608
1288394006289	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1288394006290	Melibiase; Region: Melibiase; pfam02065
1288394006291	exonuclease I; Provisional; Region: sbcB; PRK11779
1288394006292	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
1288394006293	active site
1288394006294	catalytic site [active]
1288394006295	substrate binding site [chemical binding]; other site
1288394006296	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
1288394006297	L-arabinose isomerase; Provisional; Region: PRK02929
1288394006298	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
1288394006299	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1288394006300	trimer interface [polypeptide binding]; other site
1288394006301	substrate binding site [chemical binding]; other site
1288394006302	Mn binding site [ion binding]; other site
1288394006303	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1288394006304	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1288394006305	intersubunit interface [polypeptide binding]; other site
1288394006306	active site
1288394006307	Zn2+ binding site [ion binding]; other site
1288394006308	ribulokinase; Provisional; Region: PRK04123
1288394006309	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1288394006310	N- and C-terminal domain interface [polypeptide binding]; other site
1288394006311	active site
1288394006312	MgATP binding site [chemical binding]; other site
1288394006313	catalytic site [active]
1288394006314	metal binding site [ion binding]; metal-binding site
1288394006315	carbohydrate binding site [chemical binding]; other site
1288394006316	homodimer interface [polypeptide binding]; other site
1288394006317	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1288394006318	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
1288394006319	ligand binding site [chemical binding]; other site
1288394006320	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
1288394006321	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1288394006322	Walker A/P-loop; other site
1288394006323	ATP binding site [chemical binding]; other site
1288394006324	Q-loop/lid; other site
1288394006325	ABC transporter signature motif; other site
1288394006326	Walker B; other site
1288394006327	D-loop; other site
1288394006328	H-loop/switch region; other site
1288394006329	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1288394006330	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1288394006331	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394006332	TM-ABC transporter signature motif; other site
1288394006333	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
1288394006334	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1288394006335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394006336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394006337	LysR family transcriptional regulator; Provisional; Region: PRK14997
1288394006338	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006339	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473
1288394006340	putative effector binding pocket; other site
1288394006341	putative dimerization interface [polypeptide binding]; other site
1288394006342	Pirin-related protein [General function prediction only]; Region: COG1741
1288394006343	Pirin; Region: Pirin; pfam02678
1288394006344	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1288394006345	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1288394006346	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1288394006347	DinI-like family; Region: DinI; cl11630
1288394006348	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
1288394006349	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
1288394006350	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
1288394006351	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1288394006352	active site
1288394006353	metal binding site [ion binding]; metal-binding site
1288394006354	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1288394006355	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
1288394006356	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1288394006357	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
1288394006358	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430
1288394006359	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1288394006360	tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197
1288394006361	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1288394006362	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1288394006363	dimer interface [polypeptide binding]; other site
1288394006364	active site
1288394006365	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1288394006366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394006367	Coenzyme A binding pocket [chemical binding]; other site
1288394006368	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
1288394006369	Domain of unknown function (DUF4377); Region: DUF4377; pfam14302
1288394006370	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1288394006371	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1288394006372	dimer interface [polypeptide binding]; other site
1288394006373	active site
1288394006374	citrylCoA binding site [chemical binding]; other site
1288394006375	NADH binding [chemical binding]; other site
1288394006376	cationic pore residues; other site
1288394006377	oxalacetate/citrate binding site [chemical binding]; other site
1288394006378	coenzyme A binding site [chemical binding]; other site
1288394006379	catalytic triad [active]
1288394006380	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1288394006381	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
1288394006382	SdhC subunit interface [polypeptide binding]; other site
1288394006383	proximal heme binding site [chemical binding]; other site
1288394006384	cardiolipin binding site; other site
1288394006385	Iron-sulfur protein interface; other site
1288394006386	proximal quinone binding site [chemical binding]; other site
1288394006387	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
1288394006388	L-aspartate oxidase; Provisional; Region: PRK06175
1288394006389	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1288394006390	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1288394006391	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1288394006392	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1288394006393	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1288394006394	TPP-binding site [chemical binding]; other site
1288394006395	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1288394006396	dimer interface [polypeptide binding]; other site
1288394006397	PYR/PP interface [polypeptide binding]; other site
1288394006398	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1288394006399	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394006400	E3 interaction surface; other site
1288394006401	lipoyl attachment site [posttranslational modification]; other site
1288394006402	e3 binding domain; Region: E3_binding; pfam02817
1288394006403	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1288394006404	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1288394006405	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1288394006406	CoA-ligase; Region: Ligase_CoA; pfam00549
1288394006407	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1288394006408	CoA binding domain; Region: CoA_binding; pfam02629
1288394006409	CoA-ligase; Region: Ligase_CoA; pfam00549
1288394006410	hypothetical protein; Provisional; Region: PRK05170
1288394006411	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1288394006412	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1288394006413	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1288394006414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394006415	dimer interface [polypeptide binding]; other site
1288394006416	conserved gate region; other site
1288394006417	putative PBP binding loops; other site
1288394006418	ABC-ATPase subunit interface; other site
1288394006419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394006420	dimer interface [polypeptide binding]; other site
1288394006421	conserved gate region; other site
1288394006422	putative PBP binding loops; other site
1288394006423	ABC-ATPase subunit interface; other site
1288394006424	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1288394006425	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394006426	Walker A/P-loop; other site
1288394006427	ATP binding site [chemical binding]; other site
1288394006428	Q-loop/lid; other site
1288394006429	ABC transporter signature motif; other site
1288394006430	Walker B; other site
1288394006431	D-loop; other site
1288394006432	H-loop/switch region; other site
1288394006433	TOBE domain; Region: TOBE_2; pfam08402
1288394006434	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1288394006435	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1288394006436	transcriptional regulator protein; Region: phnR; TIGR03337
1288394006437	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394006438	DNA-binding site [nucleotide binding]; DNA binding site
1288394006439	UTRA domain; Region: UTRA; pfam07702
1288394006440	2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479
1288394006441	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394006442	catalytic residue [active]
1288394006443	4-aminobutyrate aminotransferase; Provisional; Region: PRK06082
1288394006444	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394006445	inhibitor-cofactor binding pocket; inhibition site
1288394006446	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394006447	catalytic residue [active]
1288394006448	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1288394006449	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394006450	motif II; other site
1288394006451	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1288394006452	Pyruvate formate lyase 1; Region: PFL1; cd01678
1288394006453	coenzyme A binding site [chemical binding]; other site
1288394006454	active site
1288394006455	catalytic residues [active]
1288394006456	glycine loop; other site
1288394006457	formate transporter FocA; Region: formate_focA; TIGR04060
1288394006458	uncharacterized domain; Region: TIGR00702
1288394006459	YcaO-like family; Region: YcaO; pfam02624
1288394006460	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1288394006461	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
1288394006462	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1288394006463	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1288394006464	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1288394006465	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1288394006466	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1288394006467	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1288394006468	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1288394006469	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
1288394006470	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1288394006471	homodimer interface [polypeptide binding]; other site
1288394006472	substrate-cofactor binding pocket; other site
1288394006473	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394006474	catalytic residue [active]
1288394006475	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1288394006476	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1288394006477	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1288394006478	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1288394006479	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1288394006480	NAD binding site [chemical binding]; other site
1288394006481	substrate binding site [chemical binding]; other site
1288394006482	putative active site [active]
1288394006483	transcriptional regulator; Provisional; Region: PRK10632
1288394006484	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006485	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394006486	putative effector binding pocket; other site
1288394006487	dimerization interface [polypeptide binding]; other site
1288394006488	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
1288394006489	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1288394006490	NAD(P) binding site [chemical binding]; other site
1288394006491	homotetramer interface [polypeptide binding]; other site
1288394006492	homodimer interface [polypeptide binding]; other site
1288394006493	active site
1288394006494	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394006495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394006496	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1288394006497	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1288394006498	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394006499	N-terminal plug; other site
1288394006500	ligand-binding site [chemical binding]; other site
1288394006501	siderophore ferric iron reductase, AHA_1954 family; Region: sidero_Fe_reduc; TIGR03950
1288394006502	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1288394006503	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1288394006504	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006505	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1288394006506	putative dimerization interface [polypeptide binding]; other site
1288394006507	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1288394006508	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1288394006509	THF binding site; other site
1288394006510	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1288394006511	substrate binding site [chemical binding]; other site
1288394006512	THF binding site; other site
1288394006513	zinc-binding site [ion binding]; other site
1288394006514	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394006515	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394006516	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394006517	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
1288394006518	HPP family; Region: HPP; pfam04982
1288394006519	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
1288394006520	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1288394006521	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1288394006522	active site
1288394006523	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394006524	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
1288394006525	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394006526	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
1288394006527	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1288394006528	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
1288394006529	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
1288394006530	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1288394006531	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394006532	catalytic residue [active]
1288394006533	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1288394006534	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1288394006535	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_36; cd04695
1288394006536	nudix motif; other site
1288394006537	Cytochrome C biogenesis protein; Region: CcmH; cl01179
1288394006538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1288394006539	binding surface
1288394006540	TPR motif; other site
1288394006541	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394006542	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1288394006543	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1288394006544	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
1288394006545	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
1288394006546	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
1288394006547	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394006548	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
1288394006549	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
1288394006550	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1288394006551	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394006552	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394006553	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394006554	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394006555	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394006556	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394006557	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
1288394006558	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
1288394006559	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394006560	Cysteine-rich domain; Region: CCG; pfam02754
1288394006561	Cysteine-rich domain; Region: CCG; pfam02754
1288394006562	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
1288394006563	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
1288394006564	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
1288394006565	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1288394006566	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1288394006567	hypothetical protein; Provisional; Region: PRK02250
1288394006568	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
1288394006569	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1288394006570	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394006571	dimerization interface [polypeptide binding]; other site
1288394006572	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394006573	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394006574	dimer interface [polypeptide binding]; other site
1288394006575	putative CheW interface [polypeptide binding]; other site
1288394006576	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1288394006577	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1288394006578	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394006579	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394006580	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1288394006581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394006582	ATP binding site [chemical binding]; other site
1288394006583	Mg2+ binding site [ion binding]; other site
1288394006584	G-X-G motif; other site
1288394006585	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1288394006586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394006587	active site
1288394006588	phosphorylation site [posttranslational modification]
1288394006589	intermolecular recognition site; other site
1288394006590	dimerization interface [polypeptide binding]; other site
1288394006591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1288394006592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1288394006593	Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623
1288394006594	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394006595	substrate binding pocket [chemical binding]; other site
1288394006596	membrane-bound complex binding site; other site
1288394006597	hinge residues; other site
1288394006598	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394006599	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394006600	catalytic residue [active]
1288394006601	putative transporter; Provisional; Region: PRK04972
1288394006602	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1288394006603	TrkA-C domain; Region: TrkA_C; pfam02080
1288394006604	TrkA-C domain; Region: TrkA_C; pfam02080
1288394006605	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1288394006606	excinuclease ABC subunit B; Provisional; Region: PRK05298
1288394006607	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394006608	ATP binding site [chemical binding]; other site
1288394006609	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394006610	nucleotide binding region [chemical binding]; other site
1288394006611	ATP-binding site [chemical binding]; other site
1288394006612	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1288394006613	UvrB/uvrC motif; Region: UVR; pfam02151
1288394006614	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1288394006615	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1288394006616	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1288394006617	disulfide bond formation protein B; Provisional; Region: PRK01749
1288394006618	sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547
1288394006619	fatty acid metabolism regulator; Provisional; Region: PRK04984
1288394006620	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394006621	DNA-binding site [nucleotide binding]; DNA binding site
1288394006622	FadR C-terminal domain; Region: FadR_C; pfam07840
1288394006623	SpoVR family protein; Provisional; Region: PRK11767
1288394006624	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1288394006625	hypothetical protein; Provisional; Region: PRK05325
1288394006626	PrkA family serine protein kinase; Provisional; Region: PRK15455
1288394006627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394006628	Walker A motif; other site
1288394006629	ATP binding site [chemical binding]; other site
1288394006630	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1288394006631	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1288394006632	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394006633	ATP binding site [chemical binding]; other site
1288394006634	putative Mg++ binding site [ion binding]; other site
1288394006635	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394006636	nucleotide binding region [chemical binding]; other site
1288394006637	ATP-binding site [chemical binding]; other site
1288394006638	serine/threonine transporter SstT; Provisional; Region: PRK13628
1288394006639	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394006640	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
1288394006641	serine transporter; Region: stp; TIGR00814
1288394006642	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1288394006643	putative active site [active]
1288394006644	putative CoA binding site [chemical binding]; other site
1288394006645	nudix motif; other site
1288394006646	metal binding site [ion binding]; metal-binding site
1288394006647	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
1288394006648	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1288394006649	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1288394006650	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1288394006651	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1288394006652	Cell division inhibitor SulA; Region: SulA; cl01880
1288394006653	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
1288394006654	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1288394006655	homodimer interface [polypeptide binding]; other site
1288394006656	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1288394006657	active site pocket [active]
1288394006658	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1288394006659	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1288394006660	transmembrane helices; other site
1288394006661	thioredoxin 2; Provisional; Region: PRK10996
1288394006662	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1288394006663	catalytic residues [active]
1288394006664	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394006665	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394006666	dimer interface [polypeptide binding]; other site
1288394006667	phosphorylation site [posttranslational modification]
1288394006668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394006669	ATP binding site [chemical binding]; other site
1288394006670	Mg2+ binding site [ion binding]; other site
1288394006671	G-X-G motif; other site
1288394006672	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394006673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394006674	active site
1288394006675	phosphorylation site [posttranslational modification]
1288394006676	intermolecular recognition site; other site
1288394006677	dimerization interface [polypeptide binding]; other site
1288394006678	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394006679	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394006680	active site
1288394006681	phosphorylation site [posttranslational modification]
1288394006682	intermolecular recognition site; other site
1288394006683	dimerization interface [polypeptide binding]; other site
1288394006684	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
1288394006685	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1288394006686	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394006687	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394006688	Walker A/P-loop; other site
1288394006689	ATP binding site [chemical binding]; other site
1288394006690	Q-loop/lid; other site
1288394006691	ABC transporter signature motif; other site
1288394006692	Walker B; other site
1288394006693	D-loop; other site
1288394006694	H-loop/switch region; other site
1288394006695	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
1288394006696	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394006697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394006698	Walker A/P-loop; other site
1288394006699	ATP binding site [chemical binding]; other site
1288394006700	Q-loop/lid; other site
1288394006701	ABC transporter signature motif; other site
1288394006702	Walker B; other site
1288394006703	D-loop; other site
1288394006704	H-loop/switch region; other site
1288394006705	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1288394006706	active site 1 [active]
1288394006707	S4 domain; Region: S4_2; cl17325
1288394006708	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1288394006709	dimer interaction site [polypeptide binding]; other site
1288394006710	substrate-binding tunnel; other site
1288394006711	active site
1288394006712	catalytic site [active]
1288394006713	substrate binding site [chemical binding]; other site
1288394006714	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
1288394006715	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1288394006716	phasin family protein; Region: phasin_3; TIGR02809
1288394006717	pyridoxamine kinase; Validated; Region: PRK05756
1288394006718	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
1288394006719	dimer interface [polypeptide binding]; other site
1288394006720	pyridoxal binding site [chemical binding]; other site
1288394006721	ATP binding site [chemical binding]; other site
1288394006722	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1288394006723	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1288394006724	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1288394006725	dimer interface [polypeptide binding]; other site
1288394006726	active site
1288394006727	metal binding site [ion binding]; metal-binding site
1288394006728	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394006729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394006730	Coenzyme A binding pocket [chemical binding]; other site
1288394006731	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1288394006732	nudix motif; other site
1288394006733	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
1288394006734	putative active site [active]
1288394006735	putative metal binding residues [ion binding]; other site
1288394006736	signature motif; other site
1288394006737	putative triphosphate binding site [ion binding]; other site
1288394006738	dimer interface [polypeptide binding]; other site
1288394006739	hypothetical protein; Provisional; Region: PRK02237
1288394006740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394006741	Coenzyme A binding pocket [chemical binding]; other site
1288394006742	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394006743	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1288394006744	ATP binding site [chemical binding]; other site
1288394006745	putative Mg++ binding site [ion binding]; other site
1288394006746	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394006747	nucleotide binding region [chemical binding]; other site
1288394006748	ATP-binding site [chemical binding]; other site
1288394006749	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1288394006750	catalytic residues [active]
1288394006751	dimer interface [polypeptide binding]; other site
1288394006752	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
1288394006753	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1288394006754	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1288394006755	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1288394006756	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1288394006757	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1288394006758	Uncharacterized conserved protein [Function unknown]; Region: COG3148
1288394006759	hypothetical protein; Provisional; Region: PRK10621
1288394006760	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1288394006761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394006762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394006763	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394006764	dimerization interface [polypeptide binding]; other site
1288394006765	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394006766	EamA-like transporter family; Region: EamA; pfam00892
1288394006767	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394006768	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394006769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394006770	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1288394006771	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
1288394006772	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1288394006773	putative active site [active]
1288394006774	putative metal-binding site [ion binding]; other site
1288394006775	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1288394006776	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1288394006777	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1288394006778	active site
1288394006779	catalytic site [active]
1288394006780	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1288394006781	interface (dimer of trimers) [polypeptide binding]; other site
1288394006782	Substrate-binding/catalytic site; other site
1288394006783	Zn-binding sites [ion binding]; other site
1288394006784	dUMP phosphatase; Provisional; Region: PRK09449
1288394006785	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394006786	motif II; other site
1288394006787	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1288394006788	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
1288394006789	putative metal binding site [ion binding]; other site
1288394006790	dimer interface [polypeptide binding]; other site
1288394006791	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1288394006792	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1288394006793	active site
1288394006794	ADP/pyrophosphate binding site [chemical binding]; other site
1288394006795	dimerization interface [polypeptide binding]; other site
1288394006796	allosteric effector site; other site
1288394006797	fructose-1,6-bisphosphate binding site; other site
1288394006798	triosephosphate isomerase; Provisional; Region: PRK14567
1288394006799	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1288394006800	substrate binding site [chemical binding]; other site
1288394006801	dimer interface [polypeptide binding]; other site
1288394006802	catalytic triad [active]
1288394006803	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1288394006804	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1288394006805	putative active site [active]
1288394006806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394006807	S-adenosylmethionine binding site [chemical binding]; other site
1288394006808	condesin subunit F; Provisional; Region: PRK05260
1288394006809	condesin subunit E; Provisional; Region: PRK05256
1288394006810	cell division protein MukB; Provisional; Region: mukB; PRK04863
1288394006811	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1288394006812	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1288394006813	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1288394006814	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1288394006815	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1288394006816	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394006817	Coenzyme A binding pocket [chemical binding]; other site
1288394006818	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1288394006819	active site
1288394006820	catalytic residues [active]
1288394006821	metal binding site [ion binding]; metal-binding site
1288394006822	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1288394006823	PGAP1-like protein; Region: PGAP1; pfam07819
1288394006824	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
1288394006825	Pleckstrin homology-like domain; Region: PH-like; cl17171
1288394006826	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1288394006827	PhnA protein; Region: PhnA; pfam03831
1288394006828	Methyltransferase domain; Region: Methyltransf_32; pfam13679
1288394006829	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1288394006830	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
1288394006831	putative sugar binding site [chemical binding]; other site
1288394006832	catalytic residues [active]
1288394006833	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1288394006834	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1288394006835	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1288394006836	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394006837	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1288394006838	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1288394006839	catalytic core [active]
1288394006840	PAS fold; Region: PAS_4; pfam08448
1288394006841	PAS domain S-box; Region: sensory_box; TIGR00229
1288394006842	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394006843	putative active site [active]
1288394006844	heme pocket [chemical binding]; other site
1288394006845	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394006846	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394006847	metal binding site [ion binding]; metal-binding site
1288394006848	active site
1288394006849	I-site; other site
1288394006850	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
1288394006851	putative hydrophobic ligand binding site [chemical binding]; other site
1288394006852	hypothetical protein; Provisional; Region: PRK04946
1288394006853	Smr domain; Region: Smr; pfam01713
1288394006854	HemK family putative methylases; Region: hemK_fam; TIGR00536
1288394006855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394006856	S-adenosylmethionine binding site [chemical binding]; other site
1288394006857	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1288394006858	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1288394006859	Tetramer interface [polypeptide binding]; other site
1288394006860	active site
1288394006861	FMN-binding site [chemical binding]; other site
1288394006862	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394006863	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394006864	substrate binding pocket [chemical binding]; other site
1288394006865	membrane-bound complex binding site; other site
1288394006866	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1288394006867	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394006868	ATP binding site [chemical binding]; other site
1288394006869	Mg++ binding site [ion binding]; other site
1288394006870	motif III; other site
1288394006871	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394006872	nucleotide binding region [chemical binding]; other site
1288394006873	RES domain; Region: RES; smart00953
1288394006874	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
1288394006875	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1288394006876	aromatic amino acid transport protein; Region: araaP; TIGR00837
1288394006877	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
1288394006878	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394006879	DNA binding site [nucleotide binding]
1288394006880	domain linker motif; other site
1288394006881	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1288394006882	dimerization interface [polypeptide binding]; other site
1288394006883	ligand binding site [chemical binding]; other site
1288394006884	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
1288394006885	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394006886	active site
1288394006887	phosphorylation site [posttranslational modification]
1288394006888	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1288394006889	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1288394006890	dimerization domain swap beta strand [polypeptide binding]; other site
1288394006891	regulatory protein interface [polypeptide binding]; other site
1288394006892	active site
1288394006893	regulatory phosphorylation site [posttranslational modification]; other site
1288394006894	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1288394006895	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1288394006896	putative substrate binding site [chemical binding]; other site
1288394006897	putative ATP binding site [chemical binding]; other site
1288394006898	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
1288394006899	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1288394006900	active site
1288394006901	P-loop; other site
1288394006902	phosphorylation site [posttranslational modification]
1288394006903	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1288394006904	active site
1288394006905	P-loop; other site
1288394006906	phosphorylation site [posttranslational modification]
1288394006907	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
1288394006908	glucose-6-phosphate isomerase; Provisional; Region: PRK04190
1288394006909	Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560
1288394006910	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1288394006911	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394006912	DNA binding site [nucleotide binding]
1288394006913	domain linker motif; other site
1288394006914	Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289
1288394006915	putative ligand binding site [chemical binding]; other site
1288394006916	putative dimerization interface [polypeptide binding]; other site
1288394006917	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1288394006918	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1288394006919	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1288394006920	active pocket/dimerization site; other site
1288394006921	active site
1288394006922	phosphorylation site [posttranslational modification]
1288394006923	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1288394006924	active site
1288394006925	phosphorylation site [posttranslational modification]
1288394006926	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1288394006927	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1288394006928	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1288394006929	dimerization interface [polypeptide binding]; other site
1288394006930	putative active cleft [active]
1288394006931	Predicted Fe-S protein [General function prediction only]; Region: COG3313
1288394006932	murein transglycosylase A; Provisional; Region: mltA; PRK11162
1288394006933	MltA specific insert domain; Region: MltA; smart00925
1288394006934	3D domain; Region: 3D; pfam06725
1288394006935	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394006936	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1288394006937	catalytic loop [active]
1288394006938	iron binding site [ion binding]; other site
1288394006939	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1288394006940	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1288394006941	dimer interface [polypeptide binding]; other site
1288394006942	putative radical transfer pathway; other site
1288394006943	diiron center [ion binding]; other site
1288394006944	tyrosyl radical; other site
1288394006945	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
1288394006946	ATP cone domain; Region: ATP-cone; pfam03477
1288394006947	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1288394006948	active site
1288394006949	dimer interface [polypeptide binding]; other site
1288394006950	catalytic residues [active]
1288394006951	effector binding site; other site
1288394006952	R2 peptide binding site; other site
1288394006953	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1288394006954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394006955	motif II; other site
1288394006956	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1288394006957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394006958	S-adenosylmethionine binding site [chemical binding]; other site
1288394006959	DNA gyrase subunit A; Validated; Region: PRK05560
1288394006960	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1288394006961	CAP-like domain; other site
1288394006962	active site
1288394006963	primary dimer interface [polypeptide binding]; other site
1288394006964	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1288394006965	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1288394006966	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1288394006967	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1288394006968	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1288394006969	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1288394006970	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1288394006971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394006972	FeS/SAM binding site; other site
1288394006973	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1288394006974	Sel1-like repeats; Region: SEL1; smart00671
1288394006975	Sel1-like repeats; Region: SEL1; smart00671
1288394006976	Sel1 repeat; Region: Sel1; cl02723
1288394006977	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1288394006978	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1288394006979	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1288394006980	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1288394006981	active site
1288394006982	dimer interface [polypeptide binding]; other site
1288394006983	motif 1; other site
1288394006984	motif 2; other site
1288394006985	motif 3; other site
1288394006986	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1288394006987	anticodon binding site; other site
1288394006988	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1288394006989	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1288394006990	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1288394006991	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1288394006992	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1288394006993	23S rRNA binding site [nucleotide binding]; other site
1288394006994	L21 binding site [polypeptide binding]; other site
1288394006995	L13 binding site [polypeptide binding]; other site
1288394006996	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1288394006997	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1288394006998	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1288394006999	dimer interface [polypeptide binding]; other site
1288394007000	motif 1; other site
1288394007001	active site
1288394007002	motif 2; other site
1288394007003	motif 3; other site
1288394007004	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1288394007005	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1288394007006	putative tRNA-binding site [nucleotide binding]; other site
1288394007007	B3/4 domain; Region: B3_4; pfam03483
1288394007008	tRNA synthetase B5 domain; Region: B5; smart00874
1288394007009	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1288394007010	dimer interface [polypeptide binding]; other site
1288394007011	motif 1; other site
1288394007012	motif 3; other site
1288394007013	motif 2; other site
1288394007014	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1288394007015	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1288394007016	IHF dimer interface [polypeptide binding]; other site
1288394007017	IHF - DNA interface [nucleotide binding]; other site
1288394007018	ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834
1288394007019	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394007020	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394007021	substrate binding pocket [chemical binding]; other site
1288394007022	membrane-bound complex binding site; other site
1288394007023	hinge residues; other site
1288394007024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394007025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394007026	dimer interface [polypeptide binding]; other site
1288394007027	phosphorylation site [posttranslational modification]
1288394007028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394007029	ATP binding site [chemical binding]; other site
1288394007030	Mg2+ binding site [ion binding]; other site
1288394007031	G-X-G motif; other site
1288394007032	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394007033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007034	active site
1288394007035	phosphorylation site [posttranslational modification]
1288394007036	intermolecular recognition site; other site
1288394007037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007038	active site
1288394007039	phosphorylation site [posttranslational modification]
1288394007040	intermolecular recognition site; other site
1288394007041	NAD-dependent deacetylase; Provisional; Region: PRK00481
1288394007042	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
1288394007043	NAD+ binding site [chemical binding]; other site
1288394007044	substrate binding site [chemical binding]; other site
1288394007045	Zn binding site [ion binding]; other site
1288394007046	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1288394007047	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394007048	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394007049	metal binding site [ion binding]; metal-binding site
1288394007050	active site
1288394007051	I-site; other site
1288394007052	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
1288394007053	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394007054	DNA binding site [nucleotide binding]
1288394007055	domain linker motif; other site
1288394007056	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
1288394007057	dimerization interface [polypeptide binding]; other site
1288394007058	ligand binding site [chemical binding]; other site
1288394007059	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1288394007060	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1288394007061	substrate binding site [chemical binding]; other site
1288394007062	dimer interface [polypeptide binding]; other site
1288394007063	ATP binding site [chemical binding]; other site
1288394007064	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
1288394007065	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
1288394007066	ligand binding site [chemical binding]; other site
1288394007067	dimerization interface [polypeptide binding]; other site
1288394007068	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394007069	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1288394007070	TM-ABC transporter signature motif; other site
1288394007071	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
1288394007072	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1288394007073	Walker A/P-loop; other site
1288394007074	ATP binding site [chemical binding]; other site
1288394007075	Q-loop/lid; other site
1288394007076	ABC transporter signature motif; other site
1288394007077	Walker B; other site
1288394007078	D-loop; other site
1288394007079	H-loop/switch region; other site
1288394007080	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1288394007081	D-ribose pyranase; Provisional; Region: PRK11797
1288394007082	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1288394007083	glutathionine S-transferase; Provisional; Region: PRK10542
1288394007084	C-terminal domain interface [polypeptide binding]; other site
1288394007085	GSH binding site (G-site) [chemical binding]; other site
1288394007086	dimer interface [polypeptide binding]; other site
1288394007087	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1288394007088	dimer interface [polypeptide binding]; other site
1288394007089	substrate binding pocket (H-site) [chemical binding]; other site
1288394007090	N-terminal domain interface [polypeptide binding]; other site
1288394007091	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1288394007092	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
1288394007093	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1288394007094	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1288394007095	Ligand Binding Site [chemical binding]; other site
1288394007096	universal stress protein UspE; Provisional; Region: PRK11175
1288394007097	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1288394007098	Ligand Binding Site [chemical binding]; other site
1288394007099	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1288394007100	Ligand Binding Site [chemical binding]; other site
1288394007101	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
1288394007102	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394007103	ligand binding site [chemical binding]; other site
1288394007104	flexible hinge region; other site
1288394007105	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1288394007106	putative switch regulator; other site
1288394007107	non-specific DNA interactions [nucleotide binding]; other site
1288394007108	DNA binding site [nucleotide binding]
1288394007109	sequence specific DNA binding site [nucleotide binding]; other site
1288394007110	putative cAMP binding site [chemical binding]; other site
1288394007111	Family description; Region: DsbD_2; pfam13386
1288394007112	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1288394007113	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
1288394007114	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1288394007115	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1288394007116	metal-binding site [ion binding]
1288394007117	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1288394007118	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394007119	motif II; other site
1288394007120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
1288394007121	FixH; Region: FixH; pfam05751
1288394007122	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1288394007123	Cytochrome c; Region: Cytochrom_C; pfam00034
1288394007124	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1288394007125	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1288394007126	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1288394007127	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
1288394007128	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1288394007129	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1288394007130	Low-spin heme binding site [chemical binding]; other site
1288394007131	Putative water exit pathway; other site
1288394007132	Binuclear center (active site) [active]
1288394007133	Putative proton exit pathway; other site
1288394007134	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1288394007135	GAF domain; Region: GAF_2; pfam13185
1288394007136	ProP expression regulator; Provisional; Region: PRK04950
1288394007137	ProQ/FINO family; Region: ProQ; pfam04352
1288394007138	carboxy-terminal protease; Provisional; Region: PRK11186
1288394007139	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1288394007140	protein binding site [polypeptide binding]; other site
1288394007141	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1288394007142	Catalytic dyad [active]
1288394007143	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
1288394007144	aminopeptidase N; Provisional; Region: pepN; PRK14015
1288394007145	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1288394007146	active site
1288394007147	Zn binding site [ion binding]; other site
1288394007148	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
1288394007149	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1288394007150	ATP P2X receptor; Region: P2X_receptor; cl02993
1288394007151	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1288394007152	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1288394007153	quinone interaction residues [chemical binding]; other site
1288394007154	active site
1288394007155	catalytic residues [active]
1288394007156	FMN binding site [chemical binding]; other site
1288394007157	substrate binding site [chemical binding]; other site
1288394007158	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
1288394007159	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
1288394007160	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1288394007161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1288394007162	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394007163	S-adenosylmethionine binding site [chemical binding]; other site
1288394007164	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1288394007165	ABC transporter ATPase component; Reviewed; Region: PRK11147
1288394007166	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394007167	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394007168	ABC transporter; Region: ABC_tran_2; pfam12848
1288394007169	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394007170	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
1288394007171	Ribosome modulation factor; Region: RMF; pfam04957
1288394007172	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1288394007173	active site 1 [active]
1288394007174	dimer interface [polypeptide binding]; other site
1288394007175	active site 2 [active]
1288394007176	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
1288394007177	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1288394007178	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1288394007179	INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183
1288394007180	Int/Topo IB signature motif; other site
1288394007181	YebG protein; Region: YebG; pfam07130
1288394007182	Lipase (class 2); Region: Lipase_2; pfam01674
1288394007183	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394007184	PGAP1-like protein; Region: PGAP1; pfam07819
1288394007185	short chain dehydrogenase; Provisional; Region: PRK07201
1288394007186	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1288394007187	putative NAD(P) binding site [chemical binding]; other site
1288394007188	active site
1288394007189	putative substrate binding site [chemical binding]; other site
1288394007190	classical (c) SDRs; Region: SDR_c; cd05233
1288394007191	NAD(P) binding site [chemical binding]; other site
1288394007192	active site
1288394007193	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; pfam05597
1288394007194	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1288394007195	nucleophile elbow; other site
1288394007196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394007197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394007198	Bacterial transcriptional repressor; Region: TetR; pfam13972
1288394007199	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1288394007200	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1288394007201	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
1288394007202	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865
1288394007203	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
1288394007204	2-methylcitrate dehydratase; Region: prpD; TIGR02330
1288394007205	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
1288394007206	dimer interface [polypeptide binding]; other site
1288394007207	Citrate synthase; Region: Citrate_synt; pfam00285
1288394007208	active site
1288394007209	citrylCoA binding site [chemical binding]; other site
1288394007210	oxalacetate/citrate binding site [chemical binding]; other site
1288394007211	coenzyme A binding site [chemical binding]; other site
1288394007212	catalytic triad [active]
1288394007213	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1288394007214	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1288394007215	tetramer interface [polypeptide binding]; other site
1288394007216	active site
1288394007217	Mg2+/Mn2+ binding site [ion binding]; other site
1288394007218	Paraquat-inducible protein A; Region: PqiA; pfam04403
1288394007219	Paraquat-inducible protein A; Region: PqiA; pfam04403
1288394007220	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
1288394007221	mce related protein; Region: MCE; pfam02470
1288394007222	mce related protein; Region: MCE; pfam02470
1288394007223	mce related protein; Region: MCE; pfam02470
1288394007224	mce related protein; Region: MCE; pfam02470
1288394007225	mce related protein; Region: MCE; pfam02470
1288394007226	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1288394007227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394007228	S-adenosylmethionine binding site [chemical binding]; other site
1288394007229	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1288394007230	Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673
1288394007231	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1288394007232	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1288394007233	active site
1288394007234	DNA binding site [nucleotide binding]
1288394007235	Int/Topo IB signature motif; other site
1288394007236	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1288394007237	active site
1288394007238	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
1288394007239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394007240	Walker A motif; other site
1288394007241	ATP binding site [chemical binding]; other site
1288394007242	Walker B motif; other site
1288394007243	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
1288394007244	arginine finger; other site
1288394007245	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
1288394007246	thymidylate kinase; Validated; Region: tmk; PRK00698
1288394007247	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1288394007248	TMP-binding site; other site
1288394007249	ATP-binding site [chemical binding]; other site
1288394007250	YceG-like family; Region: YceG; pfam02618
1288394007251	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1288394007252	dimerization interface [polypeptide binding]; other site
1288394007253	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1288394007254	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1288394007255	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394007256	catalytic residue [active]
1288394007257	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1288394007258	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1288394007259	dimer interface [polypeptide binding]; other site
1288394007260	active site
1288394007261	acyl carrier protein; Provisional; Region: acpP; PRK00982
1288394007262	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1288394007263	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1288394007264	NAD(P) binding site [chemical binding]; other site
1288394007265	homotetramer interface [polypeptide binding]; other site
1288394007266	homodimer interface [polypeptide binding]; other site
1288394007267	active site
1288394007268	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1288394007269	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1288394007270	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1288394007271	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1288394007272	dimer interface [polypeptide binding]; other site
1288394007273	active site
1288394007274	CoA binding pocket [chemical binding]; other site
1288394007275	putative phosphate acyltransferase; Provisional; Region: PRK05331
1288394007276	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1288394007277	hypothetical protein; Provisional; Region: PRK11193
1288394007278	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1288394007279	hydrophobic ligand binding site; other site
1288394007280	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
1288394007281	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394007282	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1288394007283	dimerization interface [polypeptide binding]; other site
1288394007284	multidrug efflux system protein MdtL; Provisional; Region: PRK10473
1288394007285	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394007286	putative substrate translocation pore; other site
1288394007287	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1288394007288	active site
1288394007289	dimer interface [polypeptide binding]; other site
1288394007290	potential frameshift: common BLAST hit: gi|117619383|ref|YP_856765.1| HAD family hydrolase
1288394007291	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
1288394007292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394007293	RNA binding surface [nucleotide binding]; other site
1288394007294	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1288394007295	active site
1288394007296	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1288394007297	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1288394007298	homodimer interface [polypeptide binding]; other site
1288394007299	oligonucleotide binding site [chemical binding]; other site
1288394007300	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1288394007301	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1288394007302	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1288394007303	trimer interface [polypeptide binding]; other site
1288394007304	active site
1288394007305	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1288394007306	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1288394007307	ATP-binding site [chemical binding]; other site
1288394007308	Sugar specificity; other site
1288394007309	Pyrimidine base specificity; other site
1288394007310	Domain of unknown function DUF59; Region: DUF59; cl00941
1288394007311	antiporter inner membrane protein; Provisional; Region: PRK11670
1288394007312	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1288394007313	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
1288394007314	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1288394007315	active site
1288394007316	HIGH motif; other site
1288394007317	KMSKS motif; other site
1288394007318	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1288394007319	tRNA binding surface [nucleotide binding]; other site
1288394007320	anticodon binding site; other site
1288394007321	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1288394007322	dimer interface [polypeptide binding]; other site
1288394007323	putative tRNA-binding site [nucleotide binding]; other site
1288394007324	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1288394007325	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1288394007326	putative C-terminal domain interface [polypeptide binding]; other site
1288394007327	putative GSH binding site (G-site) [chemical binding]; other site
1288394007328	putative dimer interface [polypeptide binding]; other site
1288394007329	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1288394007330	dimer interface [polypeptide binding]; other site
1288394007331	N-terminal domain interface [polypeptide binding]; other site
1288394007332	substrate binding pocket (H-site) [chemical binding]; other site
1288394007333	Acylphosphatase; Region: Acylphosphatase; pfam00708
1288394007334	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394007335	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394007336	dimer interface [polypeptide binding]; other site
1288394007337	putative CheW interface [polypeptide binding]; other site
1288394007338	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
1288394007339	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
1288394007340	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1288394007341	putative RNA binding site [nucleotide binding]; other site
1288394007342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394007343	S-adenosylmethionine binding site [chemical binding]; other site
1288394007344	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1288394007345	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1288394007346	C-terminal domain interface [polypeptide binding]; other site
1288394007347	GSH binding site (G-site) [chemical binding]; other site
1288394007348	dimer interface [polypeptide binding]; other site
1288394007349	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1288394007350	N-terminal domain interface [polypeptide binding]; other site
1288394007351	dimer interface [polypeptide binding]; other site
1288394007352	substrate binding pocket (H-site) [chemical binding]; other site
1288394007353	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1288394007354	selenophosphate synthetase; Provisional; Region: PRK00943
1288394007355	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1288394007356	dimerization interface [polypeptide binding]; other site
1288394007357	putative ATP binding site [chemical binding]; other site
1288394007358	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1288394007359	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1288394007360	active site residue [active]
1288394007361	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1288394007362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007363	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1288394007364	active site
1288394007365	phosphorylation site [posttranslational modification]
1288394007366	intermolecular recognition site; other site
1288394007367	dimerization interface [polypeptide binding]; other site
1288394007368	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394007369	Zn2+ binding site [ion binding]; other site
1288394007370	Mg2+ binding site [ion binding]; other site
1288394007371	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394007372	dimer interface [polypeptide binding]; other site
1288394007373	phosphorylation site [posttranslational modification]
1288394007374	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394007375	ATP binding site [chemical binding]; other site
1288394007376	Mg2+ binding site [ion binding]; other site
1288394007377	G-X-G motif; other site
1288394007378	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394007379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007380	active site
1288394007381	phosphorylation site [posttranslational modification]
1288394007382	intermolecular recognition site; other site
1288394007383	dimerization interface [polypeptide binding]; other site
1288394007384	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394007385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007386	active site
1288394007387	phosphorylation site [posttranslational modification]
1288394007388	intermolecular recognition site; other site
1288394007389	dimerization interface [polypeptide binding]; other site
1288394007390	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1288394007391	5S rRNA interface [nucleotide binding]; other site
1288394007392	CTC domain interface [polypeptide binding]; other site
1288394007393	L16 interface [polypeptide binding]; other site
1288394007394	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1288394007395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394007396	ATP binding site [chemical binding]; other site
1288394007397	putative Mg++ binding site [ion binding]; other site
1288394007398	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394007399	nucleotide binding region [chemical binding]; other site
1288394007400	ATP-binding site [chemical binding]; other site
1288394007401	Helicase associated domain (HA2); Region: HA2; pfam04408
1288394007402	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1288394007403	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1288394007404	FOG: CBS domain [General function prediction only]; Region: COG0517
1288394007405	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
1288394007406	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1288394007407	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394007408	DNA binding residues [nucleotide binding]
1288394007409	dimerization interface [polypeptide binding]; other site
1288394007410	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1288394007411	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1288394007412	hypothetical protein; Validated; Region: PRK00153
1288394007413	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1288394007414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394007415	Walker A motif; other site
1288394007416	ATP binding site [chemical binding]; other site
1288394007417	Walker B motif; other site
1288394007418	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1288394007419	arginine finger; other site
1288394007420	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1288394007421	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
1288394007422	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394007423	active site
1288394007424	Protein of unknown function (DUF454); Region: DUF454; cl01063
1288394007425	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
1288394007426	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1288394007427	FMN binding site [chemical binding]; other site
1288394007428	active site
1288394007429	catalytic residues [active]
1288394007430	substrate binding site [chemical binding]; other site
1288394007431	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1288394007432	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1288394007433	catalytic residues [active]
1288394007434	Recombinase; Region: Recombinase; pfam07508
1288394007435	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1288394007436	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1288394007437	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1288394007438	catalytic residues [active]
1288394007439	catalytic nucleophile [active]
1288394007440	Recombinase; Region: Recombinase; pfam07508
1288394007441	Uncharacterized conserved protein (DUF2371); Region: DUF2371; pfam10177
1288394007442	Tail-tube assembly protein; Region: T4_tail_cap; cl17863
1288394007443	capsid vertex protein; Provisional; Region: 24; PHA02548
1288394007444	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
1288394007445	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1288394007446	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394007447	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394007448	conserved hypothetical protein; Region: TIGR02285
1288394007449	ribonuclease D; Provisional; Region: PRK10829
1288394007450	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1288394007451	catalytic site [active]
1288394007452	putative active site [active]
1288394007453	putative substrate binding site [chemical binding]; other site
1288394007454	HRDC domain; Region: HRDC; pfam00570
1288394007455	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
1288394007456	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1288394007457	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1288394007458	acyl-activating enzyme (AAE) consensus motif; other site
1288394007459	putative AMP binding site [chemical binding]; other site
1288394007460	putative active site [active]
1288394007461	putative CoA binding site [chemical binding]; other site
1288394007462	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1288394007463	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394007464	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
1288394007465	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1288394007466	Glycoprotease family; Region: Peptidase_M22; pfam00814
1288394007467	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1288394007468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1288394007469	ATP binding site [chemical binding]; other site
1288394007470	DEAD_2; Region: DEAD_2; pfam06733
1288394007471	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1288394007472	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1288394007473	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1288394007474	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1288394007475	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1288394007476	histidinol dehydrogenase; Region: hisD; TIGR00069
1288394007477	NAD binding site [chemical binding]; other site
1288394007478	dimerization interface [polypeptide binding]; other site
1288394007479	product binding site; other site
1288394007480	substrate binding site [chemical binding]; other site
1288394007481	zinc binding site [ion binding]; other site
1288394007482	catalytic residues [active]
1288394007483	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
1288394007484	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394007485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394007486	homodimer interface [polypeptide binding]; other site
1288394007487	catalytic residue [active]
1288394007488	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
1288394007489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394007490	active site
1288394007491	motif I; other site
1288394007492	motif II; other site
1288394007493	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1288394007494	putative active site pocket [active]
1288394007495	4-fold oligomerization interface [polypeptide binding]; other site
1288394007496	metal binding residues [ion binding]; metal-binding site
1288394007497	3-fold/trimer interface [polypeptide binding]; other site
1288394007498	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
1288394007499	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1288394007500	putative active site [active]
1288394007501	oxyanion strand; other site
1288394007502	catalytic triad [active]
1288394007503	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1288394007504	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1288394007505	catalytic residues [active]
1288394007506	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1288394007507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007508	active site
1288394007509	phosphorylation site [posttranslational modification]
1288394007510	intermolecular recognition site; other site
1288394007511	dimerization interface [polypeptide binding]; other site
1288394007512	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394007513	Zn2+ binding site [ion binding]; other site
1288394007514	Mg2+ binding site [ion binding]; other site
1288394007515	PAS fold; Region: PAS_4; pfam08448
1288394007516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394007517	putative active site [active]
1288394007518	heme pocket [chemical binding]; other site
1288394007519	PAS domain S-box; Region: sensory_box; TIGR00229
1288394007520	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394007521	putative active site [active]
1288394007522	heme pocket [chemical binding]; other site
1288394007523	PAS domain S-box; Region: sensory_box; TIGR00229
1288394007524	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394007525	putative active site [active]
1288394007526	heme pocket [chemical binding]; other site
1288394007527	PAS fold; Region: PAS_3; pfam08447
1288394007528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394007529	PAS fold; Region: PAS_3; pfam08447
1288394007530	putative active site [active]
1288394007531	heme pocket [chemical binding]; other site
1288394007532	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1288394007533	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394007534	putative active site [active]
1288394007535	heme pocket [chemical binding]; other site
1288394007536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394007537	dimer interface [polypeptide binding]; other site
1288394007538	phosphorylation site [posttranslational modification]
1288394007539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394007540	ATP binding site [chemical binding]; other site
1288394007541	Mg2+ binding site [ion binding]; other site
1288394007542	G-X-G motif; other site
1288394007543	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394007544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007545	active site
1288394007546	phosphorylation site [posttranslational modification]
1288394007547	intermolecular recognition site; other site
1288394007548	dimerization interface [polypeptide binding]; other site
1288394007549	Hpt domain; Region: Hpt; pfam01627
1288394007550	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1288394007551	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1288394007552	substrate binding site [chemical binding]; other site
1288394007553	glutamase interaction surface [polypeptide binding]; other site
1288394007554	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1288394007555	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1288394007556	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1288394007557	metal binding site [ion binding]; metal-binding site
1288394007558	acyl-CoA synthetase; Validated; Region: PRK08162
1288394007559	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
1288394007560	acyl-activating enzyme (AAE) consensus motif; other site
1288394007561	putative active site [active]
1288394007562	AMP binding site [chemical binding]; other site
1288394007563	putative CoA binding site [chemical binding]; other site
1288394007564	Predicted membrane protein [Function unknown]; Region: COG1288
1288394007565	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1288394007566	Pyruvate formate lyase; Region: PFL; pfam02901
1288394007567	hypothetical protein; Provisional; Region: PRK11280
1288394007568	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1288394007569	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1288394007570	generic binding surface I; other site
1288394007571	generic binding surface II; other site
1288394007572	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1288394007573	putative catalytic site [active]
1288394007574	putative metal binding site [ion binding]; other site
1288394007575	putative phosphate binding site [ion binding]; other site
1288394007576	Calx-beta domain; Region: Calx-beta; cl02522
1288394007577	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
1288394007578	xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908
1288394007579	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1288394007580	catalytic loop [active]
1288394007581	iron binding site [ion binding]; other site
1288394007582	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1288394007583	xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971
1288394007584	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1288394007585	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
1288394007586	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1288394007587	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1288394007588	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1288394007589	guanine deaminase; Provisional; Region: PRK09228
1288394007590	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1288394007591	active site
1288394007592	xanthine permease; Region: pbuX; TIGR03173
1288394007593	putative hypoxanthine oxidase; Provisional; Region: PRK09800
1288394007594	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1288394007595	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
1288394007596	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1288394007597	probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312
1288394007598	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
1288394007599	putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314
1288394007600	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1288394007601	active site
1288394007602	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
1288394007603	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1288394007604	phosphate binding site [ion binding]; other site
1288394007605	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1288394007606	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394007607	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1288394007608	metal-binding site
1288394007609	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
1288394007610	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1288394007611	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1288394007612	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1288394007613	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
1288394007614	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1288394007615	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394007616	EamA-like transporter family; Region: EamA; pfam00892
1288394007617	EamA-like transporter family; Region: EamA; pfam00892
1288394007618	carbamate kinase; Reviewed; Region: PRK12686
1288394007619	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1288394007620	putative substrate binding site [chemical binding]; other site
1288394007621	homodimer interface [polypeptide binding]; other site
1288394007622	nucleotide binding site [chemical binding]; other site
1288394007623	nucleotide binding site [chemical binding]; other site
1288394007624	phenylhydantoinase; Validated; Region: PRK08323
1288394007625	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1288394007626	tetramer interface [polypeptide binding]; other site
1288394007627	active site
1288394007628	peptidase; Reviewed; Region: PRK13004
1288394007629	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
1288394007630	putative metal binding site [ion binding]; other site
1288394007631	putative dimer interface [polypeptide binding]; other site
1288394007632	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1288394007633	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1288394007634	catalytic residue [active]
1288394007635	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
1288394007636	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1288394007637	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1288394007638	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1288394007639	GAF domain; Region: GAF; cl17456
1288394007640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394007641	Walker A motif; other site
1288394007642	ATP binding site [chemical binding]; other site
1288394007643	Walker B motif; other site
1288394007644	arginine finger; other site
1288394007645	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394007646	Mu-like prophage I protein [General function prediction only]; Region: COG4388
1288394007647	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
1288394007648	DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802
1288394007649	Protein of unknown function (DUF935); Region: DUF935; pfam06074
1288394007650	Membrane transport protein; Region: Mem_trans; cl09117
1288394007651	YaeQ protein; Region: YaeQ; pfam07152
1288394007652	TIGR02808 family protein; Region: short_TIGR02808
1288394007653	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1288394007654	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394007655	substrate binding site [chemical binding]; other site
1288394007656	oxyanion hole (OAH) forming residues; other site
1288394007657	trimer interface [polypeptide binding]; other site
1288394007658	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1288394007659	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1288394007660	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1288394007661	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1288394007662	dimer interface [polypeptide binding]; other site
1288394007663	active site
1288394007664	MoxR-like ATPases [General function prediction only]; Region: COG0714
1288394007665	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
1288394007666	Walker A motif; other site
1288394007667	ATP binding site [chemical binding]; other site
1288394007668	Walker B motif; other site
1288394007669	arginine finger; other site
1288394007670	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1288394007671	Protein of unknown function DUF58; Region: DUF58; pfam01882
1288394007672	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1288394007673	metal ion-dependent adhesion site (MIDAS); other site
1288394007674	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1288394007675	metal ion-dependent adhesion site (MIDAS); other site
1288394007676	Oxygen tolerance; Region: BatD; pfam13584
1288394007677	RNA polymerase sigma factor; Provisional; Region: PRK12517
1288394007678	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394007679	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394007680	DNA binding residues [nucleotide binding]
1288394007681	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
1288394007682	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1288394007683	potential frameshift: common BLAST hit: gi|117618313|ref|YP_856668.1| long-chain fatty acid transport protein
1288394007684	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1288394007685	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394007686	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1288394007687	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1288394007688	dimer interface [polypeptide binding]; other site
1288394007689	active site
1288394007690	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1288394007691	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1288394007692	DNA binding residues [nucleotide binding]
1288394007693	putative dimer interface [polypeptide binding]; other site
1288394007694	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1288394007695	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394007696	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1288394007697	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1288394007698	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1288394007699	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1288394007700	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1288394007701	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1288394007702	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1288394007703	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1288394007704	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394007705	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394007706	YcgL domain; Region: YcgL; cl01189
1288394007707	septum formation inhibitor; Reviewed; Region: minC; PRK04804
1288394007708	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
1288394007709	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1288394007710	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1288394007711	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1288394007712	Switch I; other site
1288394007713	Switch II; other site
1288394007714	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
1288394007715	Protein of unknown function, DUF440; Region: DUF440; pfam04269
1288394007716	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
1288394007717	Transglycosylase; Region: Transgly; cl17702
1288394007718	Protein of unknown function, DUF440; Region: DUF440; pfam04269
1288394007719	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1288394007720	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1288394007721	S1 domain; Region: S1_2; pfam13509
1288394007722	S1 domain; Region: S1_2; pfam13509
1288394007723	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
1288394007724	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1288394007725	MarR family; Region: MarR_2; pfam12802
1288394007726	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
1288394007727	azoreductase; Reviewed; Region: PRK00170
1288394007728	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1288394007729	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394007730	EamA-like transporter family; Region: EamA; pfam00892
1288394007731	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1288394007732	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394007733	ATP-grasp domain; Region: ATP-grasp; pfam02222
1288394007734	2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826
1288394007735	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1288394007736	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394007737	motif II; other site
1288394007738	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
1288394007739	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
1288394007740	Lumazine binding domain; Region: Lum_binding; pfam00677
1288394007741	Lumazine binding domain; Region: Lum_binding; pfam00677
1288394007742	hypothetical protein; Provisional; Region: PRK04964
1288394007743	multidrug efflux protein; Reviewed; Region: PRK01766
1288394007744	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1288394007745	cation binding site [ion binding]; other site
1288394007746	DNA polymerase II; Reviewed; Region: PRK05762
1288394007747	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
1288394007748	active site
1288394007749	catalytic site [active]
1288394007750	substrate binding site [chemical binding]; other site
1288394007751	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
1288394007752	active site
1288394007753	metal-binding site
1288394007754	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394007755	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394007756	metal binding site [ion binding]; metal-binding site
1288394007757	active site
1288394007758	I-site; other site
1288394007759	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394007760	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394007761	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
1288394007762	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
1288394007763	ATP binding site [chemical binding]; other site
1288394007764	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1288394007765	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1288394007766	putative acyl-acceptor binding pocket; other site
1288394007767	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1288394007768	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1288394007769	putative acyl-acceptor binding pocket; other site
1288394007770	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1288394007771	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1288394007772	gating phenylalanine in ion channel; other site
1288394007773	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
1288394007774	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394007775	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1288394007776	putative dimerization interface [polypeptide binding]; other site
1288394007777	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1288394007778	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1288394007779	endonuclease IV; Provisional; Region: PRK01060
1288394007780	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1288394007781	AP (apurinic/apyrimidinic) site pocket; other site
1288394007782	DNA interaction; other site
1288394007783	Metal-binding active site; metal-binding site
1288394007784	transcriptional regulator; Provisional; Region: PRK10632
1288394007785	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394007786	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
1288394007787	putative effector binding pocket; other site
1288394007788	putative dimerization interface [polypeptide binding]; other site
1288394007789	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1288394007790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394007791	NAD(P) binding site [chemical binding]; other site
1288394007792	active site
1288394007793	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394007794	Zn2+ binding site [ion binding]; other site
1288394007795	Mg2+ binding site [ion binding]; other site
1288394007796	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1288394007797	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394007798	Zn2+ binding site [ion binding]; other site
1288394007799	Mg2+ binding site [ion binding]; other site
1288394007800	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1288394007801	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394007802	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394007803	metal binding site [ion binding]; metal-binding site
1288394007804	active site
1288394007805	I-site; other site
1288394007806	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394007807	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1288394007808	beta-galactosidase; Region: BGL; TIGR03356
1288394007809	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394007810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394007811	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1288394007812	dimerization interface [polypeptide binding]; other site
1288394007813	substrate binding pocket [chemical binding]; other site
1288394007814	Cache domain; Region: Cache_1; pfam02743
1288394007815	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394007816	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394007817	metal binding site [ion binding]; metal-binding site
1288394007818	active site
1288394007819	I-site; other site
1288394007820	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1288394007821	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1288394007822	active site
1288394007823	catalytic tetrad [active]
1288394007824	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1288394007825	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1288394007826	active site
1288394007827	catalytic tetrad [active]
1288394007828	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394007829	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394007830	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394007831	putative effector binding pocket; other site
1288394007832	dimerization interface [polypeptide binding]; other site
1288394007833	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
1288394007834	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1288394007835	putative NAD(P) binding site [chemical binding]; other site
1288394007836	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1288394007837	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1288394007838	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1288394007839	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1288394007840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394007841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394007842	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
1288394007843	putative effector binding pocket; other site
1288394007844	putative dimerization interface [polypeptide binding]; other site
1288394007845	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1288394007846	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1288394007847	catalytic residues [active]
1288394007848	catalytic nucleophile [active]
1288394007849	Presynaptic Site I dimer interface [polypeptide binding]; other site
1288394007850	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1288394007851	Synaptic Flat tetramer interface [polypeptide binding]; other site
1288394007852	Synaptic Site I dimer interface [polypeptide binding]; other site
1288394007853	DNA binding site [nucleotide binding]
1288394007854	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1288394007855	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
1288394007856	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1288394007857	MPN+ (JAMM) motif; other site
1288394007858	Zinc-binding site [ion binding]; other site
1288394007859	Protein of unknown function DUF45; Region: DUF45; cl00636
1288394007860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394007861	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394007862	dimer interface [polypeptide binding]; other site
1288394007863	phosphorylation site [posttranslational modification]
1288394007864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394007865	ATP binding site [chemical binding]; other site
1288394007866	Mg2+ binding site [ion binding]; other site
1288394007867	G-X-G motif; other site
1288394007868	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394007869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007870	active site
1288394007871	phosphorylation site [posttranslational modification]
1288394007872	intermolecular recognition site; other site
1288394007873	dimerization interface [polypeptide binding]; other site
1288394007874	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394007875	putative binding surface; other site
1288394007876	active site
1288394007877	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394007878	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394007879	active site
1288394007880	phosphorylation site [posttranslational modification]
1288394007881	intermolecular recognition site; other site
1288394007882	dimerization interface [polypeptide binding]; other site
1288394007883	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394007884	potential frameshift: common BLAST hit: gi|145299985|ref|YP_001142826.1| ISDvu4, transposase
1288394007885	DNA primase, catalytic core; Region: dnaG; TIGR01391
1288394007886	CHC2 zinc finger; Region: zf-CHC2; cl17510
1288394007887	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1288394007888	hypothetical protein; Provisional; Region: PRK14709
1288394007889	D5 N terminal like; Region: D5_N; pfam08706
1288394007890	INT_SG2, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 2, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinases and phage-related integrases. Some have N-terminal domains, which show little sequence...; Region: INT_SG2_C; cd01184
1288394007891	Int/Topo IB signature motif; other site
1288394007892	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1288394007893	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
1288394007894	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1288394007895	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394007896	NAD(P) binding site [chemical binding]; other site
1288394007897	active site
1288394007898	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1288394007899	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1288394007900	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1288394007901	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394007902	substrate binding site [chemical binding]; other site
1288394007903	oxyanion hole (OAH) forming residues; other site
1288394007904	trimer interface [polypeptide binding]; other site
1288394007905	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1288394007906	enoyl-CoA hydratase; Provisional; Region: PRK09076
1288394007907	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394007908	substrate binding site [chemical binding]; other site
1288394007909	oxyanion hole (OAH) forming residues; other site
1288394007910	trimer interface [polypeptide binding]; other site
1288394007911	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1288394007912	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1288394007913	active site
1288394007914	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1288394007915	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1288394007916	tetrameric interface [polypeptide binding]; other site
1288394007917	NAD binding site [chemical binding]; other site
1288394007918	catalytic residues [active]
1288394007919	isovaleryl-CoA dehydrogenase; Region: PLN02519
1288394007920	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1288394007921	substrate binding site [chemical binding]; other site
1288394007922	FAD binding site [chemical binding]; other site
1288394007923	catalytic base [active]
1288394007924	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1288394007925	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1288394007926	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1288394007927	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394007928	enoyl-CoA hydratase; Provisional; Region: PRK05995
1288394007929	substrate binding site [chemical binding]; other site
1288394007930	oxyanion hole (OAH) forming residues; other site
1288394007931	trimer interface [polypeptide binding]; other site
1288394007932	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1288394007933	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1288394007934	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1288394007935	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1288394007936	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1288394007937	carboxyltransferase (CT) interaction site; other site
1288394007938	biotinylation site [posttranslational modification]; other site
1288394007939	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1288394007940	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1288394007941	active site
1288394007942	catalytic residues [active]
1288394007943	metal binding site [ion binding]; metal-binding site
1288394007944	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1288394007945	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1288394007946	DNA binding residues [nucleotide binding]
1288394007947	putative dimer interface [polypeptide binding]; other site
1288394007948	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394007949	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1288394007950	substrate binding pocket [chemical binding]; other site
1288394007951	membrane-bound complex binding site; other site
1288394007952	hinge residues; other site
1288394007953	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
1288394007954	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
1288394007955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394007956	Coenzyme A binding pocket [chemical binding]; other site
1288394007957	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1288394007958	amino acid carrier protein; Region: agcS; TIGR00835
1288394007959	potential frameshift: common BLAST hit: gi|330830152|ref|YP_004393104.1| phage protein
1288394007960	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1288394007961	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
1288394007962	enoyl-CoA hydratase; Provisional; Region: PRK07509
1288394007963	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394007964	substrate binding site [chemical binding]; other site
1288394007965	oxyanion hole (OAH) forming residues; other site
1288394007966	trimer interface [polypeptide binding]; other site
1288394007967	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
1288394007968	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394007969	ligand binding site [chemical binding]; other site
1288394007970	flexible hinge region; other site
1288394007971	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1288394007972	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1288394007973	metal binding triad; other site
1288394007974	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1288394007975	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1288394007976	active site
1288394007977	catalytic site [active]
1288394007978	substrate binding site [chemical binding]; other site
1288394007979	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1288394007980	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1288394007981	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1288394007982	Na binding site [ion binding]; other site
1288394007983	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1288394007984	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394007985	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394007986	ABC transporter; Region: ABC_tran_2; pfam12848
1288394007987	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394007988	periplasmic folding chaperone; Provisional; Region: PRK10788
1288394007989	SurA N-terminal domain; Region: SurA_N_3; cl07813
1288394007990	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1288394007991	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1288394007992	IHF dimer interface [polypeptide binding]; other site
1288394007993	IHF - DNA interface [nucleotide binding]; other site
1288394007994	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
1288394007995	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1288394007996	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394007997	Walker A motif; other site
1288394007998	ATP binding site [chemical binding]; other site
1288394007999	Walker B motif; other site
1288394008000	arginine finger; other site
1288394008001	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1288394008002	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1288394008003	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1288394008004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394008005	Walker A motif; other site
1288394008006	ATP binding site [chemical binding]; other site
1288394008007	Walker B motif; other site
1288394008008	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1288394008009	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1288394008010	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1288394008011	oligomer interface [polypeptide binding]; other site
1288394008012	active site residues [active]
1288394008013	trigger factor; Provisional; Region: tig; PRK01490
1288394008014	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1288394008015	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1288394008016	hypothetical protein; Provisional; Region: PRK11770
1288394008017	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1288394008018	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1288394008019	5'-nucleotidase; Provisional; Region: PRK03826
1288394008020	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
1288394008021	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1288394008022	FtsX-like permease family; Region: FtsX; pfam02687
1288394008023	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
1288394008024	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1288394008025	Walker A/P-loop; other site
1288394008026	ATP binding site [chemical binding]; other site
1288394008027	Q-loop/lid; other site
1288394008028	ABC transporter signature motif; other site
1288394008029	Walker B; other site
1288394008030	D-loop; other site
1288394008031	H-loop/switch region; other site
1288394008032	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1288394008033	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1288394008034	FtsX-like permease family; Region: FtsX; pfam02687
1288394008035	transcription-repair coupling factor; Provisional; Region: PRK10689
1288394008036	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1288394008037	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394008038	ATP binding site [chemical binding]; other site
1288394008039	putative Mg++ binding site [ion binding]; other site
1288394008040	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394008041	nucleotide binding region [chemical binding]; other site
1288394008042	ATP-binding site [chemical binding]; other site
1288394008043	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1288394008044	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1288394008045	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1288394008046	AMP binding site [chemical binding]; other site
1288394008047	metal binding site [ion binding]; metal-binding site
1288394008048	active site
1288394008049	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1288394008050	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1288394008051	peptide binding site [polypeptide binding]; other site
1288394008052	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394008053	EamA-like transporter family; Region: EamA; pfam00892
1288394008054	EamA-like transporter family; Region: EamA; pfam00892
1288394008055	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
1288394008056	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1288394008057	catalytic core [active]
1288394008058	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
1288394008059	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1288394008060	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1288394008061	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1288394008062	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
1288394008063	Leucine rich repeat; Region: LRR_8; pfam13855
1288394008064	Leucine rich repeat; Region: LRR_8; pfam13855
1288394008065	Protein kinase domain; Region: Pkinase; pfam00069
1288394008066	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1288394008067	active site
1288394008068	ATP binding site [chemical binding]; other site
1288394008069	substrate binding site [chemical binding]; other site
1288394008070	activation loop (A-loop); other site
1288394008071	short chain dehydrogenase; Provisional; Region: PRK07478
1288394008072	classical (c) SDRs; Region: SDR_c; cd05233
1288394008073	NAD(P) binding site [chemical binding]; other site
1288394008074	active site
1288394008075	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394008076	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394008077	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1288394008078	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1288394008079	DNA binding site [nucleotide binding]
1288394008080	active site
1288394008081	AAA ATPase domain; Region: AAA_15; pfam13175
1288394008082	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394008083	Walker A/P-loop; other site
1288394008084	ATP binding site [chemical binding]; other site
1288394008085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394008086	Walker B; other site
1288394008087	D-loop; other site
1288394008088	H-loop/switch region; other site
1288394008089	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1288394008090	putative active site [active]
1288394008091	putative metal-binding site [ion binding]; other site
1288394008092	RelB antitoxin; Region: RelB; cl01171
1288394008093	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1288394008094	AAA domain; Region: AAA_25; pfam13481
1288394008095	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
1288394008096	Walker A motif; other site
1288394008097	NTP binding site [chemical binding]; other site
1288394008098	hexamer interface [polypeptide binding]; other site
1288394008099	Walker B motif; other site
1288394008100	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
1288394008101	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
1288394008102	integrase; Provisional; Region: PRK09692
1288394008103	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1288394008104	active site
1288394008105	Int/Topo IB signature motif; other site
1288394008106	GMP synthase; Reviewed; Region: guaA; PRK00074
1288394008107	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1288394008108	AMP/PPi binding site [chemical binding]; other site
1288394008109	candidate oxyanion hole; other site
1288394008110	catalytic triad [active]
1288394008111	potential glutamine specificity residues [chemical binding]; other site
1288394008112	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1288394008113	ATP Binding subdomain [chemical binding]; other site
1288394008114	Ligand Binding sites [chemical binding]; other site
1288394008115	Dimerization subdomain; other site
1288394008116	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1288394008117	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1288394008118	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1288394008119	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1288394008120	active site
1288394008121	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
1288394008122	potassium uptake protein; Region: kup; TIGR00794
1288394008123	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1288394008124	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1288394008125	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1288394008126	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1288394008127	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1288394008128	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394008129	EamA-like transporter family; Region: EamA; pfam00892
1288394008130	EamA-like transporter family; Region: EamA; pfam00892
1288394008131	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1288394008132	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1288394008133	generic binding surface II; other site
1288394008134	generic binding surface I; other site
1288394008135	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
1288394008136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394008137	FeS/SAM binding site; other site
1288394008138	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394008139	dimerization interface [polypeptide binding]; other site
1288394008140	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394008141	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008142	dimer interface [polypeptide binding]; other site
1288394008143	putative CheW interface [polypeptide binding]; other site
1288394008144	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1288394008145	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1288394008146	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1288394008147	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1288394008148	hinge; other site
1288394008149	active site
1288394008150	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1288394008151	homodimer interface [polypeptide binding]; other site
1288394008152	substrate-cofactor binding pocket; other site
1288394008153	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394008154	catalytic residue [active]
1288394008155	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1288394008156	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1288394008157	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1288394008158	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1288394008159	Ligand binding site [chemical binding]; other site
1288394008160	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1288394008161	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1288394008162	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1288394008163	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1288394008164	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1288394008165	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
1288394008166	Cl binding site [ion binding]; other site
1288394008167	oligomer interface [polypeptide binding]; other site
1288394008168	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
1288394008169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394008170	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1288394008171	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
1288394008172	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394008173	N-terminal plug; other site
1288394008174	ligand-binding site [chemical binding]; other site
1288394008175	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1288394008176	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394008177	ABC-ATPase subunit  interface; other site
1288394008178	dimer interface [polypeptide binding]; other site
1288394008179	putative PBP binding regions; other site
1288394008180	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394008181	ABC-ATPase subunit  interface; other site
1288394008182	dimer interface [polypeptide binding]; other site
1288394008183	putative PBP binding regions; other site
1288394008184	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1288394008185	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1288394008186	Walker A/P-loop; other site
1288394008187	ATP binding site [chemical binding]; other site
1288394008188	Q-loop/lid; other site
1288394008189	ABC transporter signature motif; other site
1288394008190	Walker B; other site
1288394008191	D-loop; other site
1288394008192	H-loop/switch region; other site
1288394008193	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1288394008194	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1288394008195	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1288394008196	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1288394008197	siderophore binding site; other site
1288394008198	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1288394008199	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1288394008200	acyl-activating enzyme (AAE) consensus motif; other site
1288394008201	AMP binding site [chemical binding]; other site
1288394008202	Condensation domain; Region: Condensation; pfam00668
1288394008203	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1288394008204	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1288394008205	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1288394008206	acyl-activating enzyme (AAE) consensus motif; other site
1288394008207	AMP binding site [chemical binding]; other site
1288394008208	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1288394008209	Condensation domain; Region: Condensation; pfam00668
1288394008210	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1288394008211	Condensation domain; Region: Condensation; pfam00668
1288394008212	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1288394008213	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
1288394008214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394008215	NAD(P) binding site [chemical binding]; other site
1288394008216	active site
1288394008217	Condensation domain; Region: Condensation; pfam00668
1288394008218	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1288394008219	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1288394008220	acyl-activating enzyme (AAE) consensus motif; other site
1288394008221	AMP binding site [chemical binding]; other site
1288394008222	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1288394008223	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1288394008224	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394008225	catalytic triad [active]
1288394008226	conserved cis-peptide bond; other site
1288394008227	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
1288394008228	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
1288394008229	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1288394008230	acyl-activating enzyme (AAE) consensus motif; other site
1288394008231	active site
1288394008232	AMP binding site [chemical binding]; other site
1288394008233	substrate binding site [chemical binding]; other site
1288394008234	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1288394008235	lipoprotein; Provisional; Region: PRK10598
1288394008236	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1288394008237	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1288394008238	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1288394008239	ligand binding site; other site
1288394008240	oligomer interface; other site
1288394008241	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1288394008242	dimer interface [polypeptide binding]; other site
1288394008243	N-terminal domain interface [polypeptide binding]; other site
1288394008244	sulfate 1 binding site; other site
1288394008245	potential frameshift: common BLAST hit: gi|117618894|ref|YP_856997.1| GGDEF/eal domain-containing protein
1288394008246	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1288394008247	inosine/guanosine kinase; Provisional; Region: PRK15074
1288394008248	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1288394008249	substrate binding site [chemical binding]; other site
1288394008250	ATP binding site [chemical binding]; other site
1288394008251	MAPEG family; Region: MAPEG; cl09190
1288394008252	ferrochelatase; Reviewed; Region: hemH; PRK00035
1288394008253	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1288394008254	C-terminal domain interface [polypeptide binding]; other site
1288394008255	active site
1288394008256	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1288394008257	active site
1288394008258	N-terminal domain interface [polypeptide binding]; other site
1288394008259	adenylate kinase; Reviewed; Region: adk; PRK00279
1288394008260	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1288394008261	AMP-binding site [chemical binding]; other site
1288394008262	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1288394008263	heat shock protein 90; Provisional; Region: PRK05218
1288394008264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394008265	ATP binding site [chemical binding]; other site
1288394008266	Mg2+ binding site [ion binding]; other site
1288394008267	G-X-G motif; other site
1288394008268	recombination protein RecR; Reviewed; Region: recR; PRK00076
1288394008269	RecR protein; Region: RecR; pfam02132
1288394008270	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1288394008271	putative active site [active]
1288394008272	putative metal-binding site [ion binding]; other site
1288394008273	tetramer interface [polypeptide binding]; other site
1288394008274	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1288394008275	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
1288394008276	GAF domain; Region: GAF; pfam01590
1288394008277	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394008278	Walker A motif; other site
1288394008279	ATP binding site [chemical binding]; other site
1288394008280	Walker B motif; other site
1288394008281	arginine finger; other site
1288394008282	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394008283	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1288394008284	molybdopterin cofactor binding site; other site
1288394008285	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1288394008286	molybdopterin cofactor binding site; other site
1288394008287	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1288394008288	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
1288394008289	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
1288394008290	active site
1288394008291	catalytic triad [active]
1288394008292	dimer interface [polypeptide binding]; other site
1288394008293	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
1288394008294	potassium uptake protein; Region: kup; TIGR00794
1288394008295	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394008296	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394008297	formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042
1288394008298	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1288394008299	NADH dehydrogenase; Region: NADHdh; cl00469
1288394008300	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
1288394008301	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
1288394008302	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
1288394008303	hydrogenase 4 subunit H; Validated; Region: PRK08222
1288394008304	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394008305	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
1288394008306	Formate hydrogenlyase maturation protein HycH; Region: HycH; pfam07450
1288394008307	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
1288394008308	nickel binding site [ion binding]; other site
1288394008309	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
1288394008310	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
1288394008311	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1288394008312	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394008313	catalytic residue [active]
1288394008314	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1288394008315	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
1288394008316	G1 box; other site
1288394008317	GTP/Mg2+ binding site [chemical binding]; other site
1288394008318	G2 box; other site
1288394008319	Switch I region; other site
1288394008320	G3 box; other site
1288394008321	Switch II region; other site
1288394008322	G4 box; other site
1288394008323	G5 box; other site
1288394008324	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
1288394008325	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
1288394008326	Acylphosphatase; Region: Acylphosphatase; pfam00708
1288394008327	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1288394008328	HypF finger; Region: zf-HYPF; pfam07503
1288394008329	HypF finger; Region: zf-HYPF; pfam07503
1288394008330	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1288394008331	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
1288394008332	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1288394008333	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1288394008334	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1288394008335	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1288394008336	dimerization interface [polypeptide binding]; other site
1288394008337	ATP binding site [chemical binding]; other site
1288394008338	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1288394008339	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
1288394008340	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1288394008341	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1288394008342	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394008343	Q-loop/lid; other site
1288394008344	ABC transporter signature motif; other site
1288394008345	Walker B; other site
1288394008346	D-loop; other site
1288394008347	H-loop/switch region; other site
1288394008348	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394008349	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1288394008350	Walker A/P-loop; other site
1288394008351	ATP binding site [chemical binding]; other site
1288394008352	Q-loop/lid; other site
1288394008353	ABC transporter signature motif; other site
1288394008354	Walker B; other site
1288394008355	D-loop; other site
1288394008356	H-loop/switch region; other site
1288394008357	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1288394008358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394008359	ABC-ATPase subunit interface; other site
1288394008360	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1288394008361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394008362	dimer interface [polypeptide binding]; other site
1288394008363	conserved gate region; other site
1288394008364	putative PBP binding loops; other site
1288394008365	ABC-ATPase subunit interface; other site
1288394008366	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
1288394008367	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1288394008368	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
1288394008369	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
1288394008370	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
1288394008371	putative substrate-binding site; other site
1288394008372	nickel binding site [ion binding]; other site
1288394008373	hydrogenase 2 large subunit; Provisional; Region: PRK10467
1288394008374	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1288394008375	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
1288394008376	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
1288394008377	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
1288394008378	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1288394008379	hydrogenase 2 small subunit; Provisional; Region: PRK10468
1288394008380	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1288394008381	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394008382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394008383	active site
1288394008384	phosphorylation site [posttranslational modification]
1288394008385	intermolecular recognition site; other site
1288394008386	dimerization interface [polypeptide binding]; other site
1288394008387	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1288394008388	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1288394008389	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1288394008390	putative binding surface; other site
1288394008391	active site
1288394008392	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1288394008393	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394008394	ATP binding site [chemical binding]; other site
1288394008395	Mg2+ binding site [ion binding]; other site
1288394008396	G-X-G motif; other site
1288394008397	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1288394008398	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394008399	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394008400	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008401	dimer interface [polypeptide binding]; other site
1288394008402	putative CheW interface [polypeptide binding]; other site
1288394008403	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1288394008404	putative CheA interaction surface; other site
1288394008405	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1288394008406	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1288394008407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394008408	S-adenosylmethionine binding site [chemical binding]; other site
1288394008409	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1288394008410	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394008411	active site
1288394008412	phosphorylation site [posttranslational modification]
1288394008413	intermolecular recognition site; other site
1288394008414	dimerization interface [polypeptide binding]; other site
1288394008415	CheB methylesterase; Region: CheB_methylest; pfam01339
1288394008416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394008417	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394008418	active site
1288394008419	phosphorylation site [posttranslational modification]
1288394008420	intermolecular recognition site; other site
1288394008421	dimerization interface [polypeptide binding]; other site
1288394008422	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394008423	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394008424	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394008425	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008426	dimer interface [polypeptide binding]; other site
1288394008427	putative CheW interface [polypeptide binding]; other site
1288394008428	alanine racemase; Reviewed; Region: alr; PRK00053
1288394008429	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
1288394008430	active site
1288394008431	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394008432	substrate binding site [chemical binding]; other site
1288394008433	catalytic residues [active]
1288394008434	dimer interface [polypeptide binding]; other site
1288394008435	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1288394008436	B3/4 domain; Region: B3_4; pfam03483
1288394008437	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1288394008438	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394008439	non-specific DNA binding site [nucleotide binding]; other site
1288394008440	salt bridge; other site
1288394008441	sequence-specific DNA binding site [nucleotide binding]; other site
1288394008442	Cupin domain; Region: Cupin_2; pfam07883
1288394008443	Integrase core domain; Region: rve; pfam00665
1288394008444	Integrase core domain; Region: rve_3; pfam13683
1288394008445	Transposase; Region: HTH_Tnp_1; pfam01527
1288394008446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1288394008447	Transposase; Region: HTH_Tnp_1; cl17663
1288394008448	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1288394008449	Transposase; Region: HTH_Tnp_1; pfam01527
1288394008450	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1288394008451	AAA domain; Region: AAA_25; pfam13481
1288394008452	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1288394008453	ATP binding site [chemical binding]; other site
1288394008454	Walker A motif; other site
1288394008455	Walker B motif; other site
1288394008456	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1288394008457	active site
1288394008458	catalytic residues [active]
1288394008459	DNA binding site [nucleotide binding]
1288394008460	Int/Topo IB signature motif; other site
1288394008461	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1288394008462	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1288394008463	active site
1288394008464	DNA binding site [nucleotide binding]
1288394008465	Int/Topo IB signature motif; other site
1288394008466	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
1288394008467	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1288394008468	active site
1288394008469	DNA binding site [nucleotide binding]
1288394008470	Int/Topo IB signature motif; other site
1288394008471	putative transporter; Provisional; Region: PRK11660
1288394008472	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1288394008473	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1288394008474	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1288394008475	Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078
1288394008476	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
1288394008477	Iron permease FTR1 family; Region: FTR1; cl00475
1288394008478	hypothetical protein; Provisional; Region: PRK07208
1288394008479	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1288394008480	UDP-galactopyranose mutase; Region: GLF; pfam03275
1288394008481	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1288394008482	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394008483	putative substrate translocation pore; other site
1288394008484	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
1288394008485	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1288394008486	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1288394008487	Walker A/P-loop; other site
1288394008488	ATP binding site [chemical binding]; other site
1288394008489	Q-loop/lid; other site
1288394008490	ABC transporter signature motif; other site
1288394008491	Walker B; other site
1288394008492	D-loop; other site
1288394008493	H-loop/switch region; other site
1288394008494	FtsX-like permease family; Region: FtsX; pfam02687
1288394008495	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
1288394008496	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1288394008497	FAD binding domain; Region: FAD_binding_4; pfam01565
1288394008498	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1288394008499	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
1288394008500	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1288394008501	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1288394008502	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394008503	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1288394008504	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1288394008505	Cysteine-rich domain; Region: CCG; pfam02754
1288394008506	Cysteine-rich domain; Region: CCG; pfam02754
1288394008507	L-lactate permease; Region: Lactate_perm; cl00701
1288394008508	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
1288394008509	L-lactate permease; Region: Lactate_perm; cl00701
1288394008510	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394008511	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394008512	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394008513	putative effector binding pocket; other site
1288394008514	dimerization interface [polypeptide binding]; other site
1288394008515	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
1288394008516	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394008517	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1288394008518	dimer interface [polypeptide binding]; other site
1288394008519	active site
1288394008520	metal binding site [ion binding]; metal-binding site
1288394008521	glutathione binding site [chemical binding]; other site
1288394008522	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1288394008523	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394008524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1288394008525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394008526	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394008527	Protein of unknown function (DUF3802); Region: DUF3802; pfam12290
1288394008528	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1288394008529	N-acetylglutamate synthase; Validated; Region: PRK05279
1288394008530	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
1288394008531	putative feedback inhibition sensing region; other site
1288394008532	putative nucleotide binding site [chemical binding]; other site
1288394008533	putative substrate binding site [chemical binding]; other site
1288394008534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394008535	Coenzyme A binding pocket [chemical binding]; other site
1288394008536	aspartate kinase III; Validated; Region: PRK09084
1288394008537	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1288394008538	nucleotide binding site [chemical binding]; other site
1288394008539	substrate binding site [chemical binding]; other site
1288394008540	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932
1288394008541	lysine allosteric regulatory site; other site
1288394008542	dimer interface [polypeptide binding]; other site
1288394008543	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
1288394008544	dimer interface [polypeptide binding]; other site
1288394008545	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1288394008546	active site
1288394008547	substrate binding site [chemical binding]; other site
1288394008548	ATP binding site [chemical binding]; other site
1288394008549	Sulfatase; Region: Sulfatase; cl17466
1288394008550	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
1288394008551	putative dimer interface [polypeptide binding]; other site
1288394008552	catalytic triad [active]
1288394008553	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1288394008554	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1288394008555	active site
1288394008556	nucleophile elbow; other site
1288394008557	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
1288394008558	putative encapsidation protein; Region: PHA01076
1288394008559	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
1288394008560	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
1288394008561	FAD binding pocket [chemical binding]; other site
1288394008562	FAD binding motif [chemical binding]; other site
1288394008563	phosphate binding motif [ion binding]; other site
1288394008564	beta-alpha-beta structure motif; other site
1288394008565	NAD binding pocket [chemical binding]; other site
1288394008566	Iron coordination center [ion binding]; other site
1288394008567	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
1288394008568	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1288394008569	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1288394008570	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394008571	siroheme synthase; Provisional; Region: cysG; PRK10637
1288394008572	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1288394008573	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1288394008574	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1288394008575	active site
1288394008576	SAM binding site [chemical binding]; other site
1288394008577	homodimer interface [polypeptide binding]; other site
1288394008578	hypothetical protein; Provisional; Region: PRK02877
1288394008579	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
1288394008580	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1288394008581	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394008582	hypothetical protein; Provisional; Region: PRK04940
1288394008583	xanthine permease; Region: pbuX; TIGR03173
1288394008584	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1288394008585	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1288394008586	active site
1288394008587	Zn binding site [ion binding]; other site
1288394008588	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1288394008589	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1288394008590	Zn binding site [ion binding]; other site
1288394008591	Protein of unknown function (DUF808); Region: DUF808; pfam05661
1288394008592	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1288394008593	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1288394008594	Protein export membrane protein; Region: SecD_SecF; pfam02355
1288394008595	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
1288394008596	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933
1288394008597	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1288394008598	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1288394008599	thiamine kinase; Region: ycfN_thiK; TIGR02721
1288394008600	active site
1288394008601	substrate binding site [chemical binding]; other site
1288394008602	ATP binding site [chemical binding]; other site
1288394008603	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
1288394008604	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
1288394008605	putative dimer interface [polypeptide binding]; other site
1288394008606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
1288394008607	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1288394008608	nucleotide binding site/active site [active]
1288394008609	HIT family signature motif; other site
1288394008610	catalytic residue [active]
1288394008611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394008612	dimerization interface [polypeptide binding]; other site
1288394008613	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394008614	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008615	dimer interface [polypeptide binding]; other site
1288394008616	putative CheW interface [polypeptide binding]; other site
1288394008617	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1288394008618	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1288394008619	dihydroorotase; Reviewed; Region: PRK09236
1288394008620	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1288394008621	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1288394008622	active site
1288394008623	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394008624	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1288394008625	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1288394008626	alanine racemase; Reviewed; Region: PRK13340
1288394008627	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826
1288394008628	active site
1288394008629	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394008630	dimer interface [polypeptide binding]; other site
1288394008631	substrate binding site [chemical binding]; other site
1288394008632	catalytic residues [active]
1288394008633	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1288394008634	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1288394008635	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394008636	Walker A/P-loop; other site
1288394008637	ATP binding site [chemical binding]; other site
1288394008638	Q-loop/lid; other site
1288394008639	ABC transporter signature motif; other site
1288394008640	Walker B; other site
1288394008641	D-loop; other site
1288394008642	H-loop/switch region; other site
1288394008643	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1288394008644	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1288394008645	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
1288394008646	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394008647	Walker A/P-loop; other site
1288394008648	ATP binding site [chemical binding]; other site
1288394008649	Q-loop/lid; other site
1288394008650	ABC transporter signature motif; other site
1288394008651	Walker B; other site
1288394008652	D-loop; other site
1288394008653	H-loop/switch region; other site
1288394008654	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1288394008655	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1288394008656	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1288394008657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394008658	dimer interface [polypeptide binding]; other site
1288394008659	conserved gate region; other site
1288394008660	putative PBP binding loops; other site
1288394008661	ABC-ATPase subunit interface; other site
1288394008662	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
1288394008663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394008664	dimer interface [polypeptide binding]; other site
1288394008665	conserved gate region; other site
1288394008666	putative PBP binding loops; other site
1288394008667	ABC-ATPase subunit interface; other site
1288394008668	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1288394008669	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1288394008670	peptide binding site [polypeptide binding]; other site
1288394008671	hypothetical protein; Provisional; Region: PRK11111
1288394008672	Biofilm formation and stress response factor; Region: BsmA; pfam10014
1288394008673	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1288394008674	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1288394008675	putative catalytic cysteine [active]
1288394008676	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1288394008677	putative active site [active]
1288394008678	metal binding site [ion binding]; metal-binding site
1288394008679	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
1288394008680	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1288394008681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394008682	Zn2+ binding site [ion binding]; other site
1288394008683	Mg2+ binding site [ion binding]; other site
1288394008684	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1288394008685	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1288394008686	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1288394008687	Histidine kinase; Region: His_kinase; pfam06580
1288394008688	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394008689	ATP binding site [chemical binding]; other site
1288394008690	Mg2+ binding site [ion binding]; other site
1288394008691	G-X-G motif; other site
1288394008692	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1288394008693	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394008694	active site
1288394008695	phosphorylation site [posttranslational modification]
1288394008696	intermolecular recognition site; other site
1288394008697	dimerization interface [polypeptide binding]; other site
1288394008698	LytTr DNA-binding domain; Region: LytTR; smart00850
1288394008699	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1288394008700	Carbon starvation protein CstA; Region: CstA; pfam02554
1288394008701	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1288394008702	Protein of unknown function (DUF3302); Region: DUF3302; pfam11742
1288394008703	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394008704	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1288394008705	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394008706	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394008707	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1288394008708	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394008709	ATP binding site [chemical binding]; other site
1288394008710	putative Mg++ binding site [ion binding]; other site
1288394008711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394008712	nucleotide binding region [chemical binding]; other site
1288394008713	ATP-binding site [chemical binding]; other site
1288394008714	Orthopoxvirus interleukin 18 binding protein; Region: Pox_vIL-18BP; cl15707
1288394008715	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1288394008716	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1288394008717	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
1288394008718	GSH binding site [chemical binding]; other site
1288394008719	catalytic residues [active]
1288394008720	Protein of unknown function (DUF1653); Region: DUF1653; pfam07866
1288394008721	aminotransferase AlaT; Validated; Region: PRK09265
1288394008722	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394008723	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394008724	homodimer interface [polypeptide binding]; other site
1288394008725	catalytic residue [active]
1288394008726	Predicted membrane protein [Function unknown]; Region: COG1288
1288394008727	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1288394008728	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
1288394008729	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
1288394008730	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
1288394008731	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
1288394008732	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394008733	PAS domain; Region: PAS_9; pfam13426
1288394008734	putative active site [active]
1288394008735	heme pocket [chemical binding]; other site
1288394008736	PAS domain; Region: PAS_9; pfam13426
1288394008737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394008738	putative active site [active]
1288394008739	heme pocket [chemical binding]; other site
1288394008740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008741	dimer interface [polypeptide binding]; other site
1288394008742	putative CheW interface [polypeptide binding]; other site
1288394008743	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394008744	EamA-like transporter family; Region: EamA; pfam00892
1288394008745	EamA-like transporter family; Region: EamA; pfam00892
1288394008746	electron transport complex protein RsxA; Provisional; Region: PRK05151
1288394008747	ferredoxin; Provisional; Region: PRK08764
1288394008748	Putative Fe-S cluster; Region: FeS; pfam04060
1288394008749	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1288394008750	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
1288394008751	SLBB domain; Region: SLBB; pfam10531
1288394008752	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394008753	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
1288394008754	electron transport complex protein RnfG; Validated; Region: PRK01908
1288394008755	electron transport complex RsxE subunit; Provisional; Region: PRK12405
1288394008756	endonuclease III; Provisional; Region: PRK10702
1288394008757	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1288394008758	minor groove reading motif; other site
1288394008759	helix-hairpin-helix signature motif; other site
1288394008760	substrate binding pocket [chemical binding]; other site
1288394008761	active site
1288394008762	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1288394008763	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394008764	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1288394008765	dimer interface [polypeptide binding]; other site
1288394008766	active site
1288394008767	metal binding site [ion binding]; metal-binding site
1288394008768	glutathione binding site [chemical binding]; other site
1288394008769	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1288394008770	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394008771	ligand binding site [chemical binding]; other site
1288394008772	Nitrate and nitrite sensing; Region: NIT; pfam08376
1288394008773	HAMP domain; Region: HAMP; pfam00672
1288394008774	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394008775	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008776	dimer interface [polypeptide binding]; other site
1288394008777	putative CheW interface [polypeptide binding]; other site
1288394008778	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1288394008779	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
1288394008780	dimer interface [polypeptide binding]; other site
1288394008781	catalytic site [active]
1288394008782	putative active site [active]
1288394008783	putative substrate binding site [chemical binding]; other site
1288394008784	Predicted permease [General function prediction only]; Region: COG2056
1288394008785	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
1288394008786	helicase 45; Provisional; Region: PTZ00424
1288394008787	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394008788	ATP binding site [chemical binding]; other site
1288394008789	Mg++ binding site [ion binding]; other site
1288394008790	motif III; other site
1288394008791	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394008792	nucleotide binding region [chemical binding]; other site
1288394008793	ATP-binding site [chemical binding]; other site
1288394008794	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1288394008795	putative RNA binding site [nucleotide binding]; other site
1288394008796	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1288394008797	CoenzymeA binding site [chemical binding]; other site
1288394008798	subunit interaction site [polypeptide binding]; other site
1288394008799	PHB binding site; other site
1288394008800	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1288394008801	FAD binding domain; Region: FAD_binding_4; pfam01565
1288394008802	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1288394008803	Cation efflux family; Region: Cation_efflux; cl00316
1288394008804	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1288394008805	FOG: CBS domain [General function prediction only]; Region: COG0517
1288394008806	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1288394008807	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1288394008808	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1288394008809	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1288394008810	FMN binding site [chemical binding]; other site
1288394008811	active site
1288394008812	substrate binding site [chemical binding]; other site
1288394008813	catalytic residue [active]
1288394008814	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1288394008815	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
1288394008816	active site
1288394008817	purine riboside binding site [chemical binding]; other site
1288394008818	UMP phosphatase; Provisional; Region: PRK10444
1288394008819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394008820	active site
1288394008821	motif I; other site
1288394008822	motif II; other site
1288394008823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394008824	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1288394008825	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1288394008826	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1288394008827	TrkA-N domain; Region: TrkA_N; pfam02254
1288394008828	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
1288394008829	asparagine synthetase B; Provisional; Region: asnB; PRK09431
1288394008830	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1288394008831	active site
1288394008832	dimer interface [polypeptide binding]; other site
1288394008833	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1288394008834	Ligand Binding Site [chemical binding]; other site
1288394008835	Molecular Tunnel; other site
1288394008836	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394008837	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1288394008838	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
1288394008839	putative C-terminal domain interface [polypeptide binding]; other site
1288394008840	putative GSH binding site (G-site) [chemical binding]; other site
1288394008841	putative dimer interface [polypeptide binding]; other site
1288394008842	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
1288394008843	putative N-terminal domain interface [polypeptide binding]; other site
1288394008844	putative dimer interface [polypeptide binding]; other site
1288394008845	putative substrate binding pocket (H-site) [chemical binding]; other site
1288394008846	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1288394008847	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394008848	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1288394008849	dimer interface [polypeptide binding]; other site
1288394008850	N-terminal domain interface [polypeptide binding]; other site
1288394008851	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1288394008852	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1288394008853	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1288394008854	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1288394008855	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1288394008856	dimer interface [polypeptide binding]; other site
1288394008857	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1288394008858	active site
1288394008859	Fe binding site [ion binding]; other site
1288394008860	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1288394008861	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1288394008862	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1288394008863	active site
1288394008864	NMT1/THI5 like; Region: NMT1; pfam09084
1288394008865	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1288394008866	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394008867	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394008868	metal binding site [ion binding]; metal-binding site
1288394008869	active site
1288394008870	I-site; other site
1288394008871	PAS domain; Region: PAS_9; pfam13426
1288394008872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394008873	putative active site [active]
1288394008874	heme pocket [chemical binding]; other site
1288394008875	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394008876	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1288394008877	dimer interface [polypeptide binding]; other site
1288394008878	putative CheW interface [polypeptide binding]; other site
1288394008879	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
1288394008880	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1288394008881	Predicted integral membrane protein [Function unknown]; Region: COG0392
1288394008882	Uncharacterized conserved protein [Function unknown]; Region: COG2898
1288394008883	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1288394008884	putative metal dependent hydrolase; Provisional; Region: PRK11598
1288394008885	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
1288394008886	Sulfatase; Region: Sulfatase; pfam00884
1288394008887	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1288394008888	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1288394008889	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
1288394008890	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394008891	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394008892	putative substrate translocation pore; other site
1288394008893	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1288394008894	YccA-like proteins; Region: YccA_like; cd10433
1288394008895	TIGR01666 family membrane protein; Region: YCCS
1288394008896	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1288394008897	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1288394008898	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
1288394008899	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
1288394008900	Sporulation related domain; Region: SPOR; pfam05036
1288394008901	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
1288394008902	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1288394008903	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1288394008904	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1288394008905	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1288394008906	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1288394008907	dimerization interface 3.5A [polypeptide binding]; other site
1288394008908	active site
1288394008909	FimV N-terminal domain; Region: FimV_core; TIGR03505
1288394008910	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
1288394008911	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1288394008912	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1288394008913	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
1288394008914	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
1288394008915	ligand binding site [chemical binding]; other site
1288394008916	NAD binding site [chemical binding]; other site
1288394008917	catalytic site [active]
1288394008918	homodimer interface [polypeptide binding]; other site
1288394008919	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1288394008920	active site
1288394008921	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1288394008922	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1288394008923	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1288394008924	active site
1288394008925	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394008926	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394008927	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1288394008928	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1288394008929	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394008930	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1288394008931	catalytic triad [active]
1288394008932	dimer interface [polypeptide binding]; other site
1288394008933	conserved cis-peptide bond; other site
1288394008934	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
1288394008935	active site
1288394008936	catalytic triad [active]
1288394008937	calcium binding site 1 [ion binding]; other site
1288394008938	calcium binding site 2 [ion binding]; other site
1288394008939	calcium binding site 3 [ion binding]; other site
1288394008940	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
1288394008941	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1288394008942	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1288394008943	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1288394008944	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1288394008945	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1288394008946	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1288394008947	Helix-turn-helix domain; Region: HTH_18; pfam12833
1288394008948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394008949	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1288394008950	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1288394008951	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1288394008952	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1288394008953	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1288394008954	aromatic amino acid transporter; Provisional; Region: PRK10238
1288394008955	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1288394008956	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1288394008957	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1288394008958	metal ion-dependent adhesion site (MIDAS); other site
1288394008959	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394008960	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394008961	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394008962	metal binding site [ion binding]; metal-binding site
1288394008963	active site
1288394008964	I-site; other site
1288394008965	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394008966	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
1288394008967	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1288394008968	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1288394008969	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1288394008970	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394008971	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394008972	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
1288394008973	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1288394008974	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394008975	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
1288394008976	Walker A/P-loop; other site
1288394008977	ATP binding site [chemical binding]; other site
1288394008978	Q-loop/lid; other site
1288394008979	ABC transporter signature motif; other site
1288394008980	Walker B; other site
1288394008981	D-loop; other site
1288394008982	H-loop/switch region; other site
1288394008983	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1288394008984	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394008985	FeS/SAM binding site; other site
1288394008986	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1288394008987	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1288394008988	active site
1288394008989	dimer interface [polypeptide binding]; other site
1288394008990	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1288394008991	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1288394008992	active site
1288394008993	FMN binding site [chemical binding]; other site
1288394008994	substrate binding site [chemical binding]; other site
1288394008995	3Fe-4S cluster binding site [ion binding]; other site
1288394008996	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1288394008997	domain interface; other site
1288394008998	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
1288394008999	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394009000	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394009001	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1288394009002	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394009003	Walker A/P-loop; other site
1288394009004	ATP binding site [chemical binding]; other site
1288394009005	Q-loop/lid; other site
1288394009006	ABC transporter signature motif; other site
1288394009007	Walker B; other site
1288394009008	D-loop; other site
1288394009009	H-loop/switch region; other site
1288394009010	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394009011	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394009012	dimer interface [polypeptide binding]; other site
1288394009013	conserved gate region; other site
1288394009014	putative PBP binding loops; other site
1288394009015	ABC-ATPase subunit interface; other site
1288394009016	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009017	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394009018	substrate binding pocket [chemical binding]; other site
1288394009019	membrane-bound complex binding site; other site
1288394009020	hinge residues; other site
1288394009021	SnoaL-like domain; Region: SnoaL_3; pfam13474
1288394009022	SnoaL-like domain; Region: SnoaL_2; pfam12680
1288394009023	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1288394009024	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1288394009025	S-adenosylmethionine binding site [chemical binding]; other site
1288394009026	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1288394009027	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1288394009028	DNA binding residues [nucleotide binding]
1288394009029	dimer interface [polypeptide binding]; other site
1288394009030	[2Fe-2S] cluster binding site [ion binding]; other site
1288394009031	Protein of unknown function (DUF4243); Region: DUF4243; pfam14027
1288394009032	Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306
1288394009033	active site
1288394009034	Zn binding site [ion binding]; other site
1288394009035	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
1288394009036	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
1288394009037	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394009038	ATP binding site [chemical binding]; other site
1288394009039	Mg++ binding site [ion binding]; other site
1288394009040	motif III; other site
1288394009041	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394009042	nucleotide binding region [chemical binding]; other site
1288394009043	ATP-binding site [chemical binding]; other site
1288394009044	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
1288394009045	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1288394009046	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1288394009047	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1288394009048	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1288394009049	CHASE4 domain; Region: CHASE4; pfam05228
1288394009050	GAF domain; Region: GAF; cl17456
1288394009051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394009052	Walker A/P-loop; other site
1288394009053	ATP binding site [chemical binding]; other site
1288394009054	Q-loop/lid; other site
1288394009055	Protein of unknown function (DUF1615); Region: DUF1615; pfam07759
1288394009056	2-isopropylmalate synthase; Validated; Region: PRK03739
1288394009057	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1288394009058	active site
1288394009059	catalytic residues [active]
1288394009060	metal binding site [ion binding]; metal-binding site
1288394009061	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1288394009062	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1288394009063	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1288394009064	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1288394009065	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1288394009066	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1288394009067	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1288394009068	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1288394009069	IMP binding site; other site
1288394009070	dimer interface [polypeptide binding]; other site
1288394009071	interdomain contacts; other site
1288394009072	partial ornithine binding site; other site
1288394009073	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1288394009074	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1288394009075	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1288394009076	catalytic site [active]
1288394009077	subunit interface [polypeptide binding]; other site
1288394009078	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1288394009079	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1288394009080	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1288394009081	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
1288394009082	C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322
1288394009083	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
1288394009084	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1288394009085	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1288394009086	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1288394009087	active site
1288394009088	dimer interface [polypeptide binding]; other site
1288394009089	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1288394009090	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
1288394009091	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
1288394009092	ligand binding site [chemical binding]; other site
1288394009093	NAD binding site [chemical binding]; other site
1288394009094	tetramer interface [polypeptide binding]; other site
1288394009095	catalytic site [active]
1288394009096	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
1288394009097	L-serine binding site [chemical binding]; other site
1288394009098	ACT domain interface; other site
1288394009099	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1288394009100	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
1288394009101	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1288394009102	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394009103	Coenzyme A binding pocket [chemical binding]; other site
1288394009104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394009105	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
1288394009106	Walker A/P-loop; other site
1288394009107	ATP binding site [chemical binding]; other site
1288394009108	Q-loop/lid; other site
1288394009109	ABC transporter signature motif; other site
1288394009110	Walker B; other site
1288394009111	D-loop; other site
1288394009112	H-loop/switch region; other site
1288394009113	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394009114	dimer interface [polypeptide binding]; other site
1288394009115	putative PBP binding regions; other site
1288394009116	ABC-ATPase subunit  interface; other site
1288394009117	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394009118	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009119	substrate binding pocket [chemical binding]; other site
1288394009120	membrane-bound complex binding site; other site
1288394009121	hinge residues; other site
1288394009122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3169
1288394009123	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
1288394009124	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1288394009125	Walker A motif; other site
1288394009126	ATP binding site [chemical binding]; other site
1288394009127	Walker B motif; other site
1288394009128	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
1288394009129	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1288394009130	ligand binding site; other site
1288394009131	oligomer interface; other site
1288394009132	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1288394009133	dimer interface [polypeptide binding]; other site
1288394009134	N-terminal domain interface [polypeptide binding]; other site
1288394009135	sulfate 1 binding site; other site
1288394009136	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
1288394009137	FeoC like transcriptional regulator; Region: FeoC; pfam09012
1288394009138	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
1288394009139	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1288394009140	G1 box; other site
1288394009141	GTP/Mg2+ binding site [chemical binding]; other site
1288394009142	Switch I region; other site
1288394009143	G2 box; other site
1288394009144	G3 box; other site
1288394009145	Switch II region; other site
1288394009146	G4 box; other site
1288394009147	G5 box; other site
1288394009148	Nucleoside recognition; Region: Gate; pfam07670
1288394009149	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1288394009150	Nucleoside recognition; Region: Gate; pfam07670
1288394009151	FeoA domain; Region: FeoA; pfam04023
1288394009152	translation initiation factor Sui1; Validated; Region: PRK06824
1288394009153	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1288394009154	putative rRNA binding site [nucleotide binding]; other site
1288394009155	Predicted membrane protein [Function unknown]; Region: COG2119
1288394009156	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1288394009157	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1288394009158	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
1288394009159	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
1288394009160	Domain of unknown function (DUF4401); Region: DUF4401; pfam14351
1288394009161	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
1288394009162	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009163	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394009164	substrate binding pocket [chemical binding]; other site
1288394009165	membrane-bound complex binding site; other site
1288394009166	hinge residues; other site
1288394009167	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009168	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394009169	substrate binding pocket [chemical binding]; other site
1288394009170	membrane-bound complex binding site; other site
1288394009171	hinge residues; other site
1288394009172	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1288394009173	GAF domain; Region: GAF; cl17456
1288394009174	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394009175	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394009176	metal binding site [ion binding]; metal-binding site
1288394009177	active site
1288394009178	I-site; other site
1288394009179	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1288394009180	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1288394009181	active site
1288394009182	HIGH motif; other site
1288394009183	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1288394009184	KMSKS motif; other site
1288394009185	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1288394009186	tRNA binding surface [nucleotide binding]; other site
1288394009187	anticodon binding site; other site
1288394009188	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1288394009189	substrate binding site [chemical binding]; other site
1288394009190	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
1288394009191	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
1288394009192	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1288394009193	putative active site [active]
1288394009194	putative metal binding site [ion binding]; other site
1288394009195	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
1288394009196	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
1288394009197	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
1288394009198	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394009199	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
1288394009200	Cytochrome c; Region: Cytochrom_C; cl11414
1288394009201	Cytochrome c; Region: Cytochrom_C; cl11414
1288394009202	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
1288394009203	c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257
1288394009204	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
1288394009205	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
1288394009206	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699
1288394009207	decaheme-associated outer membrane protein, MtrB/PioB family; Region: OMP_MtrB_PioB; TIGR03509
1288394009208	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1288394009209	potential frameshift: common BLAST hit: gi|330830157|ref|YP_004393109.1| Portal vertex-like protein
1288394009210	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
1288394009211	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
1288394009212	Protein of unknown function, DUF417; Region: DUF417; cl01162
1288394009213	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1288394009214	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1288394009215	Integrase core domain; Region: rve; pfam00665
1288394009216	Integrase core domain; Region: rve_3; pfam13683
1288394009217	Transposase; Region: HTH_Tnp_1; cl17663
1288394009218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1288394009219	Transposase domain (DUF772); Region: DUF772; pfam05598
1288394009220	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
1288394009221	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1288394009222	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1288394009223	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1288394009224	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1288394009225	substrate binding site [chemical binding]; other site
1288394009226	ATP binding site [chemical binding]; other site
1288394009227	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
1288394009228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
1288394009229	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1288394009230	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1288394009231	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394009232	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1288394009233	TM-ABC transporter signature motif; other site
1288394009234	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1288394009235	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1288394009236	Walker A/P-loop; other site
1288394009237	ATP binding site [chemical binding]; other site
1288394009238	Q-loop/lid; other site
1288394009239	ABC transporter signature motif; other site
1288394009240	Walker B; other site
1288394009241	D-loop; other site
1288394009242	H-loop/switch region; other site
1288394009243	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1288394009244	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1288394009245	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1288394009246	ligand binding site [chemical binding]; other site
1288394009247	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1288394009248	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1288394009249	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1288394009250	Transposase; Region: HTH_Tnp_1; pfam01527
1288394009251	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1288394009252	HTH-like domain; Region: HTH_21; pfam13276
1288394009253	Integrase core domain; Region: rve; pfam00665
1288394009254	Integrase core domain; Region: rve_2; pfam13333
1288394009255	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1288394009256	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1288394009257	PYR/PP interface [polypeptide binding]; other site
1288394009258	dimer interface [polypeptide binding]; other site
1288394009259	TPP binding site [chemical binding]; other site
1288394009260	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1288394009261	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1288394009262	TPP-binding site; other site
1288394009263	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1288394009264	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1288394009265	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1288394009266	putative active site [active]
1288394009267	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1288394009268	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1288394009269	tetrameric interface [polypeptide binding]; other site
1288394009270	NAD binding site [chemical binding]; other site
1288394009271	catalytic residues [active]
1288394009272	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
1288394009273	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1288394009274	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1288394009275	Domain of unknown function (DUF927); Region: DUF927; pfam06048
1288394009276	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1288394009277	integrase; Provisional; Region: PRK09692
1288394009278	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
1288394009279	active site
1288394009280	Int/Topo IB signature motif; other site
1288394009281	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1288394009282	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1288394009283	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1288394009284	active site
1288394009285	catalytic site [active]
1288394009286	putative DNA binding site [nucleotide binding]; other site
1288394009287	GIY-YIG motif/motif A; other site
1288394009288	metal binding site [ion binding]; metal-binding site
1288394009289	UvrB/uvrC motif; Region: UVR; pfam02151
1288394009290	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1288394009291	response regulator; Provisional; Region: PRK09483
1288394009292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009293	active site
1288394009294	phosphorylation site [posttranslational modification]
1288394009295	intermolecular recognition site; other site
1288394009296	dimerization interface [polypeptide binding]; other site
1288394009297	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394009298	DNA binding residues [nucleotide binding]
1288394009299	dimerization interface [polypeptide binding]; other site
1288394009300	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1288394009301	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1288394009302	Ligand binding site; other site
1288394009303	oligomer interface; other site
1288394009304	Trm112p-like protein; Region: Trm112p; cl01066
1288394009305	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1288394009306	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1288394009307	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
1288394009308	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394009309	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1288394009310	Walker A/P-loop; other site
1288394009311	ATP binding site [chemical binding]; other site
1288394009312	Q-loop/lid; other site
1288394009313	ABC transporter signature motif; other site
1288394009314	Walker B; other site
1288394009315	D-loop; other site
1288394009316	H-loop/switch region; other site
1288394009317	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1288394009318	Competence protein; Region: Competence; pfam03772
1288394009319	Competence protein; Region: Competence; cl00471
1288394009320	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1288394009321	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1288394009322	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394009323	non-specific DNA binding site [nucleotide binding]; other site
1288394009324	salt bridge; other site
1288394009325	sequence-specific DNA binding site [nucleotide binding]; other site
1288394009326	Protein of unknown function (DUF3289); Region: DUF3289; cl11840
1288394009327	Fic family protein [Function unknown]; Region: COG3177
1288394009328	Fic/DOC family; Region: Fic; pfam02661
1288394009329	CRISPR/Cas system-associated transcriptional regulator CasRa; Region: CasRa_I-A; cd09655
1288394009330	DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328
1288394009331	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1288394009332	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
1288394009333	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
1288394009334	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
1288394009335	ATP binding site [chemical binding]; other site
1288394009336	threonine and homoserine efflux system; Provisional; Region: PRK10532
1288394009337	EamA-like transporter family; Region: EamA; pfam00892
1288394009338	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394009339	dimerization interface [polypeptide binding]; other site
1288394009340	putative DNA binding site [nucleotide binding]; other site
1288394009341	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1288394009342	putative Zn2+ binding site [ion binding]; other site
1288394009343	AsnC family; Region: AsnC_trans_reg; pfam01037
1288394009344	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1288394009345	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1288394009346	inhibitor site; inhibition site
1288394009347	active site
1288394009348	dimer interface [polypeptide binding]; other site
1288394009349	catalytic residue [active]
1288394009350	transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481
1288394009351	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394009352	DNA-binding site [nucleotide binding]; DNA binding site
1288394009353	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394009354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394009355	homodimer interface [polypeptide binding]; other site
1288394009356	catalytic residue [active]
1288394009357	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1288394009358	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1288394009359	metal ion-dependent adhesion site (MIDAS); other site
1288394009360	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1288394009361	active site
1288394009362	ATP binding site [chemical binding]; other site
1288394009363	substrate binding site [chemical binding]; other site
1288394009364	activation loop (A-loop); other site
1288394009365	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
1288394009366	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1288394009367	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
1288394009368	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
1288394009369	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1288394009370	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1288394009371	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394009372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394009373	homodimer interface [polypeptide binding]; other site
1288394009374	catalytic residue [active]
1288394009375	type III secretion system protein; Validated; Region: PRK06298
1288394009376	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
1288394009377	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
1288394009378	trimer interface [polypeptide binding]; other site
1288394009379	eyelet of channel; other site
1288394009380	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
1288394009381	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1288394009382	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1288394009383	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
1288394009384	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1288394009385	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
1288394009386	putative active site [active]
1288394009387	Zn binding site [ion binding]; other site
1288394009388	putative MFS family transporter protein; Provisional; Region: PRK03633
1288394009389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394009390	putative substrate translocation pore; other site
1288394009391	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1288394009392	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1288394009393	GTP/Mg2+ binding site [chemical binding]; other site
1288394009394	G4 box; other site
1288394009395	G5 box; other site
1288394009396	G1 box; other site
1288394009397	Switch I region; other site
1288394009398	G2 box; other site
1288394009399	G3 box; other site
1288394009400	Switch II region; other site
1288394009401	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1288394009402	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1288394009403	active site
1288394009404	dimer interface [polypeptide binding]; other site
1288394009405	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1288394009406	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1288394009407	active site
1288394009408	dimer interface [polypeptide binding]; other site
1288394009409	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009410	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
1288394009411	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1288394009412	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
1288394009413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009414	active site
1288394009415	phosphorylation site [posttranslational modification]
1288394009416	intermolecular recognition site; other site
1288394009417	dimerization interface [polypeptide binding]; other site
1288394009418	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394009419	DNA binding residues [nucleotide binding]
1288394009420	dimerization interface [polypeptide binding]; other site
1288394009421	sensory histidine kinase UhpB; Provisional; Region: PRK11644
1288394009422	MASE1; Region: MASE1; cl17823
1288394009423	Histidine kinase; Region: HisKA_3; pfam07730
1288394009424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394009425	ATP binding site [chemical binding]; other site
1288394009426	Mg2+ binding site [ion binding]; other site
1288394009427	G-X-G motif; other site
1288394009428	regulatory protein UhpC; Provisional; Region: PRK11663
1288394009429	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394009430	putative substrate translocation pore; other site
1288394009431	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394009432	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394009433	metal binding site [ion binding]; metal-binding site
1288394009434	active site
1288394009435	I-site; other site
1288394009436	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394009437	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009438	substrate binding pocket [chemical binding]; other site
1288394009439	membrane-bound complex binding site; other site
1288394009440	hinge residues; other site
1288394009441	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394009442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394009443	dimer interface [polypeptide binding]; other site
1288394009444	conserved gate region; other site
1288394009445	putative PBP binding loops; other site
1288394009446	ABC-ATPase subunit interface; other site
1288394009447	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1288394009448	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1288394009449	Walker A/P-loop; other site
1288394009450	ATP binding site [chemical binding]; other site
1288394009451	Q-loop/lid; other site
1288394009452	ABC transporter signature motif; other site
1288394009453	Walker B; other site
1288394009454	D-loop; other site
1288394009455	H-loop/switch region; other site
1288394009456	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394009457	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1288394009458	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1288394009459	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
1288394009460	Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040
1288394009461	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1288394009462	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1288394009463	Domain of unknown function DUF21; Region: DUF21; pfam01595
1288394009464	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1288394009465	Transporter associated domain; Region: CorC_HlyC; smart01091
1288394009466	transcriptional regulator PhoU; Provisional; Region: PRK11115
1288394009467	PhoU domain; Region: PhoU; pfam01895
1288394009468	PhoU domain; Region: PhoU; pfam01895
1288394009469	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
1288394009470	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1288394009471	Walker A/P-loop; other site
1288394009472	ATP binding site [chemical binding]; other site
1288394009473	Q-loop/lid; other site
1288394009474	ABC transporter signature motif; other site
1288394009475	Walker B; other site
1288394009476	D-loop; other site
1288394009477	H-loop/switch region; other site
1288394009478	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
1288394009479	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1288394009480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394009481	dimer interface [polypeptide binding]; other site
1288394009482	conserved gate region; other site
1288394009483	putative PBP binding loops; other site
1288394009484	ABC-ATPase subunit interface; other site
1288394009485	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
1288394009486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394009487	dimer interface [polypeptide binding]; other site
1288394009488	conserved gate region; other site
1288394009489	putative PBP binding loops; other site
1288394009490	ABC-ATPase subunit interface; other site
1288394009491	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1288394009492	nucleoside/Zn binding site; other site
1288394009493	dimer interface [polypeptide binding]; other site
1288394009494	catalytic motif [active]
1288394009495	malate synthase A; Region: malate_syn_A; TIGR01344
1288394009496	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
1288394009497	active site
1288394009498	isocitrate lyase; Provisional; Region: PRK15063
1288394009499	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1288394009500	tetramer interface [polypeptide binding]; other site
1288394009501	active site
1288394009502	Mg2+/Mn2+ binding site [ion binding]; other site
1288394009503	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1288394009504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1288394009505	Walker A motif; other site
1288394009506	ATP binding site [chemical binding]; other site
1288394009507	Walker B motif; other site
1288394009508	arginine finger; other site
1288394009509	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
1288394009510	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394009511	active site
1288394009512	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1288394009513	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1288394009514	dimerization interface [polypeptide binding]; other site
1288394009515	putative ATP binding site [chemical binding]; other site
1288394009516	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1288394009517	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1288394009518	active site
1288394009519	substrate binding site [chemical binding]; other site
1288394009520	cosubstrate binding site; other site
1288394009521	catalytic site [active]
1288394009522	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1288394009523	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
1288394009524	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1288394009525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009526	active site
1288394009527	phosphorylation site [posttranslational modification]
1288394009528	intermolecular recognition site; other site
1288394009529	dimerization interface [polypeptide binding]; other site
1288394009530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394009531	Walker A motif; other site
1288394009532	ATP binding site [chemical binding]; other site
1288394009533	Walker B motif; other site
1288394009534	arginine finger; other site
1288394009535	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394009536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394009537	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394009538	putative active site [active]
1288394009539	heme pocket [chemical binding]; other site
1288394009540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394009541	dimer interface [polypeptide binding]; other site
1288394009542	phosphorylation site [posttranslational modification]
1288394009543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394009544	ATP binding site [chemical binding]; other site
1288394009545	Mg2+ binding site [ion binding]; other site
1288394009546	G-X-G motif; other site
1288394009547	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
1288394009548	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1288394009549	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394009550	Walker A motif; other site
1288394009551	ATP binding site [chemical binding]; other site
1288394009552	Walker B motif; other site
1288394009553	arginine finger; other site
1288394009554	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394009555	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
1288394009556	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1288394009557	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
1288394009558	ACT domain; Region: ACT_6; pfam13740
1288394009559	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
1288394009560	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
1288394009561	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1288394009562	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1288394009563	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
1288394009564	domain interface [polypeptide binding]; other site
1288394009565	active site
1288394009566	catalytic site [active]
1288394009567	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
1288394009568	domain interface [polypeptide binding]; other site
1288394009569	active site
1288394009570	catalytic site [active]
1288394009571	exopolyphosphatase; Provisional; Region: PRK10854
1288394009572	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1288394009573	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1288394009574	MgtE intracellular N domain; Region: MgtE_N; pfam03448
1288394009575	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1288394009576	Divalent cation transporter; Region: MgtE; pfam01769
1288394009577	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
1288394009578	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1288394009579	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK05683
1288394009580	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1288394009581	Rod binding protein; Region: Rod-binding; cl01626
1288394009582	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
1288394009583	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1288394009584	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
1288394009585	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1288394009586	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698
1288394009587	Flagellar L-ring protein; Region: FlgH; pfam02107
1288394009588	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
1288394009589	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1288394009590	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1288394009591	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
1288394009592	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1288394009593	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1288394009594	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1288394009595	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1288394009596	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1288394009597	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634
1288394009598	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1288394009599	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1288394009600	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631
1288394009601	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1288394009602	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1288394009603	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12625
1288394009604	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1288394009605	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1288394009606	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1288394009607	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394009608	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1288394009609	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394009610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009611	active site
1288394009612	phosphorylation site [posttranslational modification]
1288394009613	intermolecular recognition site; other site
1288394009614	dimerization interface [polypeptide binding]; other site
1288394009615	SAF-like; Region: SAF_2; pfam13144
1288394009616	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1288394009617	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1288394009618	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
1288394009619	FlgN protein; Region: FlgN; pfam05130
1288394009620	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1288394009621	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1288394009622	active site
1288394009623	metal binding site [ion binding]; metal-binding site
1288394009624	homotetramer interface [polypeptide binding]; other site
1288394009625	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1288394009626	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1288394009627	peptide binding site [polypeptide binding]; other site
1288394009628	EamA-like transporter family; Region: EamA; pfam00892
1288394009629	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1288394009630	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394009631	RNA binding surface [nucleotide binding]; other site
1288394009632	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1288394009633	active site
1288394009634	uracil binding [chemical binding]; other site
1288394009635	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
1288394009636	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1288394009637	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394009638	Zn2+ binding site [ion binding]; other site
1288394009639	Mg2+ binding site [ion binding]; other site
1288394009640	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1288394009641	active site
1288394009642	intersubunit interactions; other site
1288394009643	catalytic residue [active]
1288394009644	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1288394009645	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394009646	FeS/SAM binding site; other site
1288394009647	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
1288394009648	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1288394009649	dimer interface [polypeptide binding]; other site
1288394009650	active site
1288394009651	glycine loop; other site
1288394009652	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1288394009653	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1288394009654	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1288394009655	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1288394009656	EamA-like transporter family; Region: EamA; pfam00892
1288394009657	EamA-like transporter family; Region: EamA; pfam00892
1288394009658	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1288394009659	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1288394009660	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
1288394009661	Phosphate-starvation-inducible E; Region: PsiE; cl01264
1288394009662	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1288394009663	DNA-binding site [nucleotide binding]; DNA binding site
1288394009664	RNA-binding motif; other site
1288394009665	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1288394009666	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394009667	E3 interaction surface; other site
1288394009668	lipoyl attachment site [posttranslational modification]; other site
1288394009669	e3 binding domain; Region: E3_binding; pfam02817
1288394009670	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1288394009671	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1288394009672	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1288394009673	alpha subunit interface [polypeptide binding]; other site
1288394009674	TPP binding site [chemical binding]; other site
1288394009675	heterodimer interface [polypeptide binding]; other site
1288394009676	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1288394009677	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1288394009678	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1288394009679	tetramer interface [polypeptide binding]; other site
1288394009680	TPP-binding site [chemical binding]; other site
1288394009681	heterodimer interface [polypeptide binding]; other site
1288394009682	phosphorylation loop region [posttranslational modification]
1288394009683	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
1288394009684	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1288394009685	putative active site [active]
1288394009686	Zn binding site [ion binding]; other site
1288394009687	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
1288394009688	DNA replication terminus site-binding protein (Ter protein); Region: Ter; pfam05472
1288394009689	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1288394009690	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394009691	ATP binding site [chemical binding]; other site
1288394009692	putative Mg++ binding site [ion binding]; other site
1288394009693	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394009694	nucleotide binding region [chemical binding]; other site
1288394009695	ATP-binding site [chemical binding]; other site
1288394009696	hypothetical protein; Provisional; Region: PRK11239
1288394009697	Protein of unknown function, DUF480; Region: DUF480; pfam04337
1288394009698	O-Antigen ligase; Region: Wzy_C; pfam04932
1288394009699	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1288394009700	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
1288394009701	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
1288394009702	Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419
1288394009703	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
1288394009704	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
1288394009705	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
1288394009706	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1288394009707	SLBB domain; Region: SLBB; pfam10531
1288394009708	SLBB domain; Region: SLBB; pfam10531
1288394009709	LPS O-antigen length regulator; Provisional; Region: PRK10381
1288394009710	Chain length determinant protein; Region: Wzz; pfam02706
1288394009711	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1288394009712	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1288394009713	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1288394009714	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1288394009715	substrate binding site; other site
1288394009716	tetramer interface; other site
1288394009717	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1288394009718	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1288394009719	NADP binding site [chemical binding]; other site
1288394009720	active site
1288394009721	putative substrate binding site [chemical binding]; other site
1288394009722	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
1288394009723	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1288394009724	Mg++ binding site [ion binding]; other site
1288394009725	putative catalytic motif [active]
1288394009726	substrate binding site [chemical binding]; other site
1288394009727	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1288394009728	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
1288394009729	active site
1288394009730	substrate binding site [chemical binding]; other site
1288394009731	metal binding site [ion binding]; metal-binding site
1288394009732	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1288394009733	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1288394009734	metal-binding site
1288394009735	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1288394009736	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1288394009737	Substrate binding site; other site
1288394009738	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1288394009739	GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430
1288394009740	active site
1288394009741	GDP-Mannose binding site [chemical binding]; other site
1288394009742	dimer interface [polypeptide binding]; other site
1288394009743	modified nudix motif
1288394009744	metal binding site [ion binding]; metal-binding site
1288394009745	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1288394009746	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1288394009747	NADP binding site [chemical binding]; other site
1288394009748	active site
1288394009749	putative substrate binding site [chemical binding]; other site
1288394009750	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1288394009751	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1288394009752	substrate binding site [chemical binding]; other site
1288394009753	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394009754	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1288394009755	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1288394009756	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394009757	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1288394009758	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1288394009759	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1288394009760	putative trimer interface [polypeptide binding]; other site
1288394009761	putative CoA binding site [chemical binding]; other site
1288394009762	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
1288394009763	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1288394009764	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1288394009765	inhibitor-cofactor binding pocket; inhibition site
1288394009766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394009767	catalytic residue [active]
1288394009768	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1288394009769	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1288394009770	putative trimer interface [polypeptide binding]; other site
1288394009771	putative active site [active]
1288394009772	putative substrate binding site [chemical binding]; other site
1288394009773	putative CoA binding site [chemical binding]; other site
1288394009774	WxcM-like, C-terminal; Region: FdtA; pfam05523
1288394009775	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1288394009776	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1288394009777	substrate binding site; other site
1288394009778	tetramer interface; other site
1288394009779	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
1288394009780	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1288394009781	NAD binding site [chemical binding]; other site
1288394009782	substrate binding site [chemical binding]; other site
1288394009783	homodimer interface [polypeptide binding]; other site
1288394009784	active site
1288394009785	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1288394009786	Protein export membrane protein; Region: SecD_SecF; cl14618
1288394009787	Protein export membrane protein; Region: SecD_SecF; cl14618
1288394009788	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1288394009789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394009790	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394009791	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
1288394009792	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394009793	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
1288394009794	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1288394009795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394009796	S-adenosylmethionine binding site [chemical binding]; other site
1288394009797	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1288394009798	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394009799	acyl-CoA thioesterase II; Provisional; Region: PRK10526
1288394009800	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1288394009801	active site
1288394009802	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1288394009803	catalytic triad [active]
1288394009804	dimer interface [polypeptide binding]; other site
1288394009805	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
1288394009806	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394009807	RNA binding surface [nucleotide binding]; other site
1288394009808	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
1288394009809	probable active site [active]
1288394009810	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1288394009811	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1288394009812	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1288394009813	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1288394009814	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1288394009815	active site
1288394009816	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1288394009817	anthranilate synthase component I; Provisional; Region: PRK13564
1288394009818	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1288394009819	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1288394009820	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1288394009821	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1288394009822	glutamine binding [chemical binding]; other site
1288394009823	catalytic triad [active]
1288394009824	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1288394009825	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1288394009826	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1288394009827	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
1288394009828	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1288394009829	active site
1288394009830	ribulose/triose binding site [chemical binding]; other site
1288394009831	phosphate binding site [ion binding]; other site
1288394009832	substrate (anthranilate) binding pocket [chemical binding]; other site
1288394009833	product (indole) binding pocket [chemical binding]; other site
1288394009834	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1288394009835	active site
1288394009836	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1288394009837	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1288394009838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394009839	catalytic residue [active]
1288394009840	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1288394009841	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1288394009842	substrate binding site [chemical binding]; other site
1288394009843	active site
1288394009844	catalytic residues [active]
1288394009845	heterodimer interface [polypeptide binding]; other site
1288394009846	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
1288394009847	Beta/Gamma crystallin; Region: Crystall; cl02528
1288394009848	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816
1288394009849	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1288394009850	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1288394009851	Nucleoside recognition; Region: Gate; pfam07670
1288394009852	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1288394009853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394009854	TPR motif; other site
1288394009855	binding surface
1288394009856	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1288394009857	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1288394009858	putative active site [active]
1288394009859	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cl17348
1288394009860	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
1288394009861	spermidine synthase; Provisional; Region: PRK03612
1288394009862	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1288394009863	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
1288394009864	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
1288394009865	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394009866	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1288394009867	catalytic triad [active]
1288394009868	conserved cis-peptide bond; other site
1288394009869	CoA binding domain; Region: CoA_binding; pfam02629
1288394009870	CoA-ligase; Region: Ligase_CoA; pfam00549
1288394009871	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
1288394009872	carbamate kinase; Reviewed; Region: PRK12686
1288394009873	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1288394009874	putative substrate binding site [chemical binding]; other site
1288394009875	nucleotide binding site [chemical binding]; other site
1288394009876	nucleotide binding site [chemical binding]; other site
1288394009877	homodimer interface [polypeptide binding]; other site
1288394009878	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
1288394009879	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1288394009880	Na binding site [ion binding]; other site
1288394009881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394009882	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1288394009883	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394009884	dimerization interface [polypeptide binding]; other site
1288394009885	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1288394009886	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394009887	non-specific DNA binding site [nucleotide binding]; other site
1288394009888	salt bridge; other site
1288394009889	sequence-specific DNA binding site [nucleotide binding]; other site
1288394009890	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1288394009891	Protein of unknown function (DUF2787); Region: DUF2787; pfam10980
1288394009892	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1288394009893	MPN+ (JAMM) motif; other site
1288394009894	Zinc-binding site [ion binding]; other site
1288394009895	Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in...; Region: PI3Ka; cl00271
1288394009896	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1288394009897	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
1288394009898	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1288394009899	molybdopterin cofactor binding site [chemical binding]; other site
1288394009900	substrate binding site [chemical binding]; other site
1288394009901	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1288394009902	molybdopterin cofactor binding site; other site
1288394009903	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1288394009904	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
1288394009905	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
1288394009906	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009907	active site
1288394009908	phosphorylation site [posttranslational modification]
1288394009909	intermolecular recognition site; other site
1288394009910	dimerization interface [polypeptide binding]; other site
1288394009911	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394009912	DNA binding site [nucleotide binding]
1288394009913	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1288394009914	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
1288394009915	TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955
1288394009916	putative ligand binding site [chemical binding]; other site
1288394009917	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
1288394009918	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394009919	dimerization interface [polypeptide binding]; other site
1288394009920	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394009921	dimer interface [polypeptide binding]; other site
1288394009922	phosphorylation site [posttranslational modification]
1288394009923	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394009924	ATP binding site [chemical binding]; other site
1288394009925	Mg2+ binding site [ion binding]; other site
1288394009926	G-X-G motif; other site
1288394009927	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009928	active site
1288394009929	phosphorylation site [posttranslational modification]
1288394009930	intermolecular recognition site; other site
1288394009931	dimerization interface [polypeptide binding]; other site
1288394009932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394009933	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394009934	putative substrate translocation pore; other site
1288394009935	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
1288394009936	UbiA prenyltransferase family; Region: UbiA; pfam01040
1288394009937	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
1288394009938	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1288394009939	Subunit I/III interface [polypeptide binding]; other site
1288394009940	Subunit III/IV interface [polypeptide binding]; other site
1288394009941	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1288394009942	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1288394009943	D-pathway; other site
1288394009944	Putative ubiquinol binding site [chemical binding]; other site
1288394009945	Low-spin heme (heme b) binding site [chemical binding]; other site
1288394009946	Putative water exit pathway; other site
1288394009947	Binuclear center (heme o3/CuB) [ion binding]; other site
1288394009948	K-pathway; other site
1288394009949	Putative proton exit pathway; other site
1288394009950	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
1288394009951	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1288394009952	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1288394009953	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
1288394009954	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1288394009955	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1288394009956	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1288394009957	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1288394009958	Protein of unknown function (DUF3634); Region: DUF3634; pfam12321
1288394009959	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1288394009960	active site
1288394009961	HutD; Region: HutD; pfam05962
1288394009962	azurin; Region: azurin; TIGR02695
1288394009963	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
1288394009964	ApbE family; Region: ApbE; pfam02424
1288394009965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394009966	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394009967	putative substrate translocation pore; other site
1288394009968	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394009969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394009970	active site
1288394009971	phosphorylation site [posttranslational modification]
1288394009972	intermolecular recognition site; other site
1288394009973	dimerization interface [polypeptide binding]; other site
1288394009974	TPR repeat; Region: TPR_11; pfam13414
1288394009975	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394009976	TPR motif; other site
1288394009977	binding surface
1288394009978	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1288394009979	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1288394009980	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1288394009981	Ion channel; Region: Ion_trans_2; pfam07885
1288394009982	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1288394009983	putative catalytic site [active]
1288394009984	putative phosphate binding site [ion binding]; other site
1288394009985	active site
1288394009986	metal binding site A [ion binding]; metal-binding site
1288394009987	DNA binding site [nucleotide binding]
1288394009988	putative AP binding site [nucleotide binding]; other site
1288394009989	putative metal binding site B [ion binding]; other site
1288394009990	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
1288394009991	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394009992	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394009993	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1288394009994	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
1288394009995	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394009996	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1288394009997	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1288394009998	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
1288394009999	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1288394010000	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394010001	catalytic residue [active]
1288394010002	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
1288394010003	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1288394010004	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1288394010005	NMT1/THI5 like; Region: NMT1; pfam09084
1288394010006	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1288394010007	PAS domain S-box; Region: sensory_box; TIGR00229
1288394010008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394010009	putative active site [active]
1288394010010	heme pocket [chemical binding]; other site
1288394010011	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394010012	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394010013	metal binding site [ion binding]; metal-binding site
1288394010014	active site
1288394010015	I-site; other site
1288394010016	Hemerythrin; Region: Hemerythrin; cd12107
1288394010017	Fe binding site [ion binding]; other site
1288394010018	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1288394010019	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1288394010020	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1288394010021	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394010022	Predicted transporter component [General function prediction only]; Region: COG2391
1288394010023	Sulphur transport; Region: Sulf_transp; pfam04143
1288394010024	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
1288394010025	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394010026	dimerization interface [polypeptide binding]; other site
1288394010027	putative DNA binding site [nucleotide binding]; other site
1288394010028	putative Zn2+ binding site [ion binding]; other site
1288394010029	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1288394010030	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1288394010031	MgtC family; Region: MgtC; pfam02308
1288394010032	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
1288394010033	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394010034	DNA binding site [nucleotide binding]
1288394010035	domain linker motif; other site
1288394010036	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
1288394010037	dimerization interface [polypeptide binding]; other site
1288394010038	ligand binding site [chemical binding]; other site
1288394010039	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1288394010040	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1288394010041	substrate binding [chemical binding]; other site
1288394010042	active site
1288394010043	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1288394010044	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394010045	active site turn [active]
1288394010046	phosphorylation site [posttranslational modification]
1288394010047	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394010048	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1288394010049	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1288394010050	putative substrate binding site [chemical binding]; other site
1288394010051	putative ATP binding site [chemical binding]; other site
1288394010052	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
1288394010053	trimer interface; other site
1288394010054	sugar binding site [chemical binding]; other site
1288394010055	chaperone protein DnaJ; Provisional; Region: PRK10767
1288394010056	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1288394010057	HSP70 interaction site [polypeptide binding]; other site
1288394010058	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1288394010059	substrate binding site [polypeptide binding]; other site
1288394010060	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1288394010061	Zn binding sites [ion binding]; other site
1288394010062	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1288394010063	dimer interface [polypeptide binding]; other site
1288394010064	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1288394010065	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1288394010066	nucleotide binding site [chemical binding]; other site
1288394010067	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1288394010068	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1288394010069	dimer interface [polypeptide binding]; other site
1288394010070	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1288394010071	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
1288394010072	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
1288394010073	recombination and repair protein; Provisional; Region: PRK10869
1288394010074	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1288394010075	Walker A/P-loop; other site
1288394010076	ATP binding site [chemical binding]; other site
1288394010077	Q-loop/lid; other site
1288394010078	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1288394010079	Q-loop/lid; other site
1288394010080	ABC transporter signature motif; other site
1288394010081	Walker B; other site
1288394010082	D-loop; other site
1288394010083	H-loop/switch region; other site
1288394010084	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1288394010085	DHH family; Region: DHH; pfam01368
1288394010086	DHHA2 domain; Region: DHHA2; pfam02833
1288394010087	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1288394010088	macrolide transporter subunit MacA; Provisional; Region: PRK11578
1288394010089	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394010090	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394010091	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
1288394010092	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1288394010093	Walker A/P-loop; other site
1288394010094	ATP binding site [chemical binding]; other site
1288394010095	Q-loop/lid; other site
1288394010096	ABC transporter signature motif; other site
1288394010097	Walker B; other site
1288394010098	D-loop; other site
1288394010099	H-loop/switch region; other site
1288394010100	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1288394010101	FtsX-like permease family; Region: FtsX; pfam02687
1288394010102	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
1288394010103	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1288394010104	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1288394010105	FAD binding pocket [chemical binding]; other site
1288394010106	FAD binding motif [chemical binding]; other site
1288394010107	phosphate binding motif [ion binding]; other site
1288394010108	NAD binding pocket [chemical binding]; other site
1288394010109	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822
1288394010110	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1288394010111	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
1288394010112	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1288394010113	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394010114	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394010115	Coenzyme A binding pocket [chemical binding]; other site
1288394010116	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1288394010117	putative hydrophobic ligand binding site [chemical binding]; other site
1288394010118	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1288394010119	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1288394010120	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1288394010121	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394010122	non-specific DNA binding site [nucleotide binding]; other site
1288394010123	salt bridge; other site
1288394010124	sequence-specific DNA binding site [nucleotide binding]; other site
1288394010125	Cupin domain; Region: Cupin_2; pfam07883
1288394010126	succinic semialdehyde dehydrogenase; Region: PLN02278
1288394010127	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1288394010128	tetramerization interface [polypeptide binding]; other site
1288394010129	NAD(P) binding site [chemical binding]; other site
1288394010130	catalytic residues [active]
1288394010131	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394010132	4-aminobutyrate aminotransferase; Provisional; Region: PRK07495
1288394010133	inhibitor-cofactor binding pocket; inhibition site
1288394010134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394010135	catalytic residue [active]
1288394010136	amino acid transporter; Region: 2A0306; TIGR00909
1288394010137	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1288394010138	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1288394010139	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1288394010140	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
1288394010141	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1288394010142	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1288394010143	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1288394010144	putative active site [active]
1288394010145	metal binding site [ion binding]; metal-binding site
1288394010146	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394010147	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394010148	substrate binding pocket [chemical binding]; other site
1288394010149	membrane-bound complex binding site; other site
1288394010150	hinge residues; other site
1288394010151	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394010152	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1288394010153	substrate binding pocket [chemical binding]; other site
1288394010154	membrane-bound complex binding site; other site
1288394010155	hinge residues; other site
1288394010156	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1288394010157	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394010158	putative active site [active]
1288394010159	heme pocket [chemical binding]; other site
1288394010160	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394010161	dimer interface [polypeptide binding]; other site
1288394010162	phosphorylation site [posttranslational modification]
1288394010163	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394010164	ATP binding site [chemical binding]; other site
1288394010165	Mg2+ binding site [ion binding]; other site
1288394010166	G-X-G motif; other site
1288394010167	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394010168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394010169	active site
1288394010170	phosphorylation site [posttranslational modification]
1288394010171	intermolecular recognition site; other site
1288394010172	dimerization interface [polypeptide binding]; other site
1288394010173	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394010174	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1288394010175	ligand binding site [chemical binding]; other site
1288394010176	flexible hinge region; other site
1288394010177	putative transporter; Provisional; Region: PRK03699
1288394010178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394010179	putative substrate translocation pore; other site
1288394010180	purine nucleoside phosphorylase; Provisional; Region: PRK13374
1288394010181	Uncharacterized conserved protein [Function unknown]; Region: COG4938
1288394010182	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1288394010183	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010184	Walker A/P-loop; other site
1288394010185	ATP binding site [chemical binding]; other site
1288394010186	Q-loop/lid; other site
1288394010187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010188	Q-loop/lid; other site
1288394010189	ABC transporter signature motif; other site
1288394010190	Walker B; other site
1288394010191	D-loop; other site
1288394010192	H-loop/switch region; other site
1288394010193	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394010194	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1288394010195	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1288394010196	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1288394010197	threonine synthase; Validated; Region: PRK09225
1288394010198	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394010199	catalytic residue [active]
1288394010200	homoserine kinase; Provisional; Region: PRK01212
1288394010201	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1288394010202	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1288394010203	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
1288394010204	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
1288394010205	putative catalytic residues [active]
1288394010206	putative nucleotide binding site [chemical binding]; other site
1288394010207	putative aspartate binding site [chemical binding]; other site
1288394010208	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
1288394010209	dimer interface [polypeptide binding]; other site
1288394010210	putative threonine allosteric regulatory site; other site
1288394010211	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
1288394010212	putative threonine allosteric regulatory site; other site
1288394010213	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1288394010214	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1288394010215	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1288394010216	putative RNA methyltransferase; Provisional; Region: PRK10433
1288394010217	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
1288394010218	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
1288394010219	META domain; Region: META; pfam03724
1288394010220	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1288394010221	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
1288394010222	two-component response regulator; Provisional; Region: PRK11173
1288394010223	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394010224	active site
1288394010225	phosphorylation site [posttranslational modification]
1288394010226	intermolecular recognition site; other site
1288394010227	dimerization interface [polypeptide binding]; other site
1288394010228	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394010229	DNA binding site [nucleotide binding]
1288394010230	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
1288394010231	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394010232	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010233	Walker A/P-loop; other site
1288394010234	ATP binding site [chemical binding]; other site
1288394010235	Q-loop/lid; other site
1288394010236	ABC transporter signature motif; other site
1288394010237	Walker B; other site
1288394010238	D-loop; other site
1288394010239	H-loop/switch region; other site
1288394010240	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
1288394010241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010242	Walker A/P-loop; other site
1288394010243	ATP binding site [chemical binding]; other site
1288394010244	Q-loop/lid; other site
1288394010245	ABC transporter signature motif; other site
1288394010246	Walker B; other site
1288394010247	D-loop; other site
1288394010248	H-loop/switch region; other site
1288394010249	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
1288394010250	Protein of unknown function, DUF488; Region: DUF488; cl01246
1288394010251	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1288394010252	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394010253	NAD(P) binding site [chemical binding]; other site
1288394010254	active site
1288394010255	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1288394010256	homodimer interaction site [polypeptide binding]; other site
1288394010257	cofactor binding site; other site
1288394010258	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
1288394010259	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1288394010260	dimer interface [polypeptide binding]; other site
1288394010261	active site
1288394010262	CoA binding pocket [chemical binding]; other site
1288394010263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1288394010264	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1288394010265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394010266	Walker A motif; other site
1288394010267	ATP binding site [chemical binding]; other site
1288394010268	Walker B motif; other site
1288394010269	arginine finger; other site
1288394010270	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1288394010271	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1288394010272	dimer interface [polypeptide binding]; other site
1288394010273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394010274	catalytic residue [active]
1288394010275	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1288394010276	dimerization domain swap beta strand [polypeptide binding]; other site
1288394010277	regulatory protein interface [polypeptide binding]; other site
1288394010278	active site
1288394010279	regulatory phosphorylation site [posttranslational modification]; other site
1288394010280	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
1288394010281	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1288394010282	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1288394010283	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1288394010284	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1288394010285	HPr interaction site; other site
1288394010286	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1288394010287	active site
1288394010288	phosphorylation site [posttranslational modification]
1288394010289	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394010290	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394010291	metal binding site [ion binding]; metal-binding site
1288394010292	active site
1288394010293	I-site; other site
1288394010294	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394010295	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1288394010296	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1288394010297	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010298	AAA domain; Region: AAA_23; pfam13476
1288394010299	Walker A/P-loop; other site
1288394010300	ATP binding site [chemical binding]; other site
1288394010301	Q-loop/lid; other site
1288394010302	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010303	Q-loop/lid; other site
1288394010304	ABC transporter signature motif; other site
1288394010305	Walker B; other site
1288394010306	D-loop; other site
1288394010307	H-loop/switch region; other site
1288394010308	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394010309	Walker A/P-loop; other site
1288394010310	ATP binding site [chemical binding]; other site
1288394010311	exonuclease subunit SbcD; Provisional; Region: PRK10966
1288394010312	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1288394010313	active site
1288394010314	metal binding site [ion binding]; metal-binding site
1288394010315	DNA binding site [nucleotide binding]
1288394010316	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1288394010317	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394010318	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394010319	Coenzyme A binding pocket [chemical binding]; other site
1288394010320	recombination associated protein; Reviewed; Region: rdgC; PRK00321
1288394010321	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1288394010322	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1288394010323	putative cation:proton antiport protein; Provisional; Region: PRK10669
1288394010324	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
1288394010325	TrkA-N domain; Region: TrkA_N; pfam02254
1288394010326	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879
1288394010327	Peptidase family M28; Region: Peptidase_M28; pfam04389
1288394010328	active site
1288394010329	metal binding site [ion binding]; metal-binding site
1288394010330	pyruvate kinase; Provisional; Region: PRK09206
1288394010331	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1288394010332	domain interfaces; other site
1288394010333	active site
1288394010334	hypothetical protein; Provisional; Region: PRK11281
1288394010335	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1288394010336	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394010337	6-phosphogluconolactonase; Provisional; Region: PRK11028
1288394010338	uracil-xanthine permease; Region: ncs2; TIGR00801
1288394010339	Hint domain; Region: Hint_2; pfam13403
1288394010340	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
1288394010341	malate dehydrogenase; Provisional; Region: PRK13529
1288394010342	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1288394010343	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
1288394010344	NAD(P) binding site [chemical binding]; other site
1288394010345	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394010346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394010347	active site
1288394010348	phosphorylation site [posttranslational modification]
1288394010349	intermolecular recognition site; other site
1288394010350	dimerization interface [polypeptide binding]; other site
1288394010351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394010352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394010353	ATP binding site [chemical binding]; other site
1288394010354	Mg2+ binding site [ion binding]; other site
1288394010355	G-X-G motif; other site
1288394010356	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1288394010357	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1288394010358	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1288394010359	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
1288394010360	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1288394010361	[4Fe-4S] binding site [ion binding]; other site
1288394010362	molybdopterin cofactor binding site; other site
1288394010363	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1288394010364	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1288394010365	molybdopterin cofactor binding site; other site
1288394010366	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
1288394010367	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1288394010368	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394010369	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394010370	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394010371	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1288394010372	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
1288394010373	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
1288394010374	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
1288394010375	Helix-turn-helix domain; Region: HTH_17; pfam12728
1288394010376	PBP superfamily domain; Region: PBP_like; pfam12727
1288394010377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394010378	dimer interface [polypeptide binding]; other site
1288394010379	phosphorylation site [posttranslational modification]
1288394010380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394010381	ATP binding site [chemical binding]; other site
1288394010382	G-X-G motif; other site
1288394010383	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1288394010384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394010385	active site
1288394010386	phosphorylation site [posttranslational modification]
1288394010387	intermolecular recognition site; other site
1288394010388	dimerization interface [polypeptide binding]; other site
1288394010389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394010390	Walker A motif; other site
1288394010391	ATP binding site [chemical binding]; other site
1288394010392	Walker B motif; other site
1288394010393	arginine finger; other site
1288394010394	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394010395	PBP superfamily domain; Region: PBP_like_2; pfam12849
1288394010396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394010397	dimer interface [polypeptide binding]; other site
1288394010398	conserved gate region; other site
1288394010399	putative PBP binding loops; other site
1288394010400	ABC-ATPase subunit interface; other site
1288394010401	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1288394010402	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1288394010403	Walker A/P-loop; other site
1288394010404	ATP binding site [chemical binding]; other site
1288394010405	Q-loop/lid; other site
1288394010406	ABC transporter signature motif; other site
1288394010407	Walker B; other site
1288394010408	D-loop; other site
1288394010409	H-loop/switch region; other site
1288394010410	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1288394010411	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1288394010412	GTP binding site; other site
1288394010413	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
1288394010414	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1288394010415	Walker A motif; other site
1288394010416	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1288394010417	dimer interface [polypeptide binding]; other site
1288394010418	putative functional site; other site
1288394010419	putative MPT binding site; other site
1288394010420	Predicted membrane protein [Function unknown]; Region: COG1289
1288394010421	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1288394010422	HD domain; Region: HD_5; pfam13487
1288394010423	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1288394010424	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394010425	Zn2+ binding site [ion binding]; other site
1288394010426	Mg2+ binding site [ion binding]; other site
1288394010427	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
1288394010428	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394010429	PAS domain; Region: PAS_9; pfam13426
1288394010430	putative active site [active]
1288394010431	heme pocket [chemical binding]; other site
1288394010432	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394010433	PAS domain; Region: PAS_9; pfam13426
1288394010434	putative active site [active]
1288394010435	heme pocket [chemical binding]; other site
1288394010436	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394010437	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394010438	dimer interface [polypeptide binding]; other site
1288394010439	putative CheW interface [polypeptide binding]; other site
1288394010440	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394010441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394010442	Coenzyme A binding pocket [chemical binding]; other site
1288394010443	Predicted membrane protein [Function unknown]; Region: COG2259
1288394010444	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1288394010445	hypothetical protein; Provisional; Region: PRK05409
1288394010446	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
1288394010447	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
1288394010448	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394010449	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394010450	dimerization interface [polypeptide binding]; other site
1288394010451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394010452	dimer interface [polypeptide binding]; other site
1288394010453	phosphorylation site [posttranslational modification]
1288394010454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394010455	ATP binding site [chemical binding]; other site
1288394010456	Mg2+ binding site [ion binding]; other site
1288394010457	G-X-G motif; other site
1288394010458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394010459	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394010460	active site
1288394010461	phosphorylation site [posttranslational modification]
1288394010462	intermolecular recognition site; other site
1288394010463	dimerization interface [polypeptide binding]; other site
1288394010464	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394010465	putative active site [active]
1288394010466	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
1288394010467	substrate binding site [chemical binding]; other site
1288394010468	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1288394010469	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1288394010470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394010471	dimer interface [polypeptide binding]; other site
1288394010472	conserved gate region; other site
1288394010473	putative PBP binding loops; other site
1288394010474	ABC-ATPase subunit interface; other site
1288394010475	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1288394010476	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1288394010477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394010478	dimer interface [polypeptide binding]; other site
1288394010479	conserved gate region; other site
1288394010480	putative PBP binding loops; other site
1288394010481	ABC-ATPase subunit interface; other site
1288394010482	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1288394010483	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394010484	Walker A/P-loop; other site
1288394010485	ATP binding site [chemical binding]; other site
1288394010486	Q-loop/lid; other site
1288394010487	ABC transporter signature motif; other site
1288394010488	Walker B; other site
1288394010489	D-loop; other site
1288394010490	H-loop/switch region; other site
1288394010491	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1288394010492	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1288394010493	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394010494	Walker A/P-loop; other site
1288394010495	ATP binding site [chemical binding]; other site
1288394010496	Q-loop/lid; other site
1288394010497	ABC transporter signature motif; other site
1288394010498	Walker B; other site
1288394010499	D-loop; other site
1288394010500	H-loop/switch region; other site
1288394010501	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1288394010502	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
1288394010503	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1288394010504	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
1288394010505	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
1288394010506	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1288394010507	active site
1288394010508	PAS domain; Region: PAS_9; pfam13426
1288394010509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394010510	putative active site [active]
1288394010511	heme pocket [chemical binding]; other site
1288394010512	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394010513	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394010514	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1288394010515	active site
1288394010516	DNA binding site [nucleotide binding]
1288394010517	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1288394010518	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1288394010519	active site
1288394010520	interdomain interaction site; other site
1288394010521	putative metal-binding site [ion binding]; other site
1288394010522	nucleotide binding site [chemical binding]; other site
1288394010523	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1288394010524	domain I; other site
1288394010525	DNA binding groove [nucleotide binding]
1288394010526	phosphate binding site [ion binding]; other site
1288394010527	domain II; other site
1288394010528	domain III; other site
1288394010529	nucleotide binding site [chemical binding]; other site
1288394010530	catalytic site [active]
1288394010531	domain IV; other site
1288394010532	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1288394010533	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1288394010534	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1288394010535	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
1288394010536	succinylarginine dihydrolase; Provisional; Region: PRK13281
1288394010537	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
1288394010538	putative inner membrane peptidase; Provisional; Region: PRK11778
1288394010539	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1288394010540	tandem repeat interface [polypeptide binding]; other site
1288394010541	oligomer interface [polypeptide binding]; other site
1288394010542	active site residues [active]
1288394010543	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
1288394010544	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394010545	NAD(P) binding site [chemical binding]; other site
1288394010546	active site
1288394010547	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394010548	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394010549	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1288394010550	sugar efflux transporter B; Provisional; Region: PRK15011
1288394010551	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394010552	putative substrate translocation pore; other site
1288394010553	putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350
1288394010554	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394010555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394010556	homodimer interface [polypeptide binding]; other site
1288394010557	catalytic residue [active]
1288394010558	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1288394010559	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1288394010560	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394010561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394010562	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394010563	dimerization interface [polypeptide binding]; other site
1288394010564	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1288394010565	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1288394010566	GDP-binding site [chemical binding]; other site
1288394010567	ACT binding site; other site
1288394010568	IMP binding site; other site
1288394010569	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1288394010570	substrate binding site [chemical binding]; other site
1288394010571	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394010572	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394010573	alpha-glucosidase; Provisional; Region: PRK10137
1288394010574	Protein of unknown function, DUF608; Region: DUF608; pfam04685
1288394010575	Trehalase; Region: Trehalase; cl17346
1288394010576	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1288394010577	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1288394010578	active site
1288394010579	HIGH motif; other site
1288394010580	dimer interface [polypeptide binding]; other site
1288394010581	KMSKS motif; other site
1288394010582	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394010583	RNA binding surface [nucleotide binding]; other site
1288394010584	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1288394010585	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1288394010586	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394010587	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1288394010588	chaperone protein HchA; Provisional; Region: PRK04155
1288394010589	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1288394010590	conserved cys residue [active]
1288394010591	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1288394010592	homotrimer interaction site [polypeptide binding]; other site
1288394010593	putative active site [active]
1288394010594	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1288394010595	homotrimer interaction site [polypeptide binding]; other site
1288394010596	putative active site [active]
1288394010597	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1288394010598	homotrimer interaction site [polypeptide binding]; other site
1288394010599	putative active site [active]
1288394010600	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394010601	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394010602	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1288394010603	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394010604	DNA binding site [nucleotide binding]
1288394010605	transketolase; Reviewed; Region: PRK12753
1288394010606	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1288394010607	TPP-binding site [chemical binding]; other site
1288394010608	dimer interface [polypeptide binding]; other site
1288394010609	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1288394010610	PYR/PP interface [polypeptide binding]; other site
1288394010611	dimer interface [polypeptide binding]; other site
1288394010612	TPP binding site [chemical binding]; other site
1288394010613	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1288394010614	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1288394010615	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1288394010616	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1288394010617	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1288394010618	hypothetical protein; Provisional; Region: PRK04860
1288394010619	SprT homologues; Region: SprT; cl01182
1288394010620	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
1288394010621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1288394010622	RNA methyltransferase, RsmE family; Region: TIGR00046
1288394010623	glutathione synthetase; Provisional; Region: PRK05246
1288394010624	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1288394010625	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1288394010626	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394010627	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394010628	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394010629	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394010630	dimer interface [polypeptide binding]; other site
1288394010631	putative CheW interface [polypeptide binding]; other site
1288394010632	hypothetical protein; Validated; Region: PRK00228
1288394010633	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1288394010634	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
1288394010635	POT family; Region: PTR2; cl17359
1288394010636	beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289
1288394010637	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1288394010638	MoxR-like ATPases [General function prediction only]; Region: COG0714
1288394010639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394010640	Walker A motif; other site
1288394010641	ATP binding site [chemical binding]; other site
1288394010642	Walker B motif; other site
1288394010643	arginine finger; other site
1288394010644	Protein of unknown function DUF58; Region: DUF58; pfam01882
1288394010645	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
1288394010646	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1288394010647	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1288394010648	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1288394010649	amino acid carrier protein; Region: agcS; TIGR00835
1288394010650	transaldolase-like protein; Provisional; Region: PTZ00411
1288394010651	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1288394010652	active site
1288394010653	dimer interface [polypeptide binding]; other site
1288394010654	catalytic residue [active]
1288394010655	Protein of unknown function (DUF3545); Region: DUF3545; pfam12065
1288394010656	Hemerythrin-like domain; Region: Hr-like; cd12108
1288394010657	Fe binding site [ion binding]; other site
1288394010658	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1288394010659	ligand binding site [chemical binding]; other site
1288394010660	active site
1288394010661	UGI interface [polypeptide binding]; other site
1288394010662	catalytic site [active]
1288394010663	autonomous glycyl radical cofactor GrcA; Region: spare_glycyl; TIGR04365
1288394010664	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1288394010665	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394010666	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1288394010667	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1288394010668	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1288394010669	Tetratricopeptide repeat; Region: TPR_9; pfam13371
1288394010670	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394010671	TPR motif; other site
1288394010672	Invasion gene expression up-regulator, SirB; Region: SirB; cl01184
1288394010673	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1288394010674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394010675	S-adenosylmethionine binding site [chemical binding]; other site
1288394010676	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1288394010677	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1288394010678	RF-1 domain; Region: RF-1; pfam00472
1288394010679	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1288394010680	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1288394010681	tRNA; other site
1288394010682	putative tRNA binding site [nucleotide binding]; other site
1288394010683	putative NADP binding site [chemical binding]; other site
1288394010684	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1288394010685	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
1288394010686	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
1288394010687	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
1288394010688	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1288394010689	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1288394010690	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1288394010691	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1288394010692	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394010693	active site
1288394010694	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
1288394010695	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1288394010696	active site
1288394010697	metal binding site [ion binding]; metal-binding site
1288394010698	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1288394010699	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1288394010700	putative active site [active]
1288394010701	catalytic residue [active]
1288394010702	GTP-binding protein YchF; Reviewed; Region: PRK09601
1288394010703	YchF GTPase; Region: YchF; cd01900
1288394010704	G1 box; other site
1288394010705	GTP/Mg2+ binding site [chemical binding]; other site
1288394010706	Switch I region; other site
1288394010707	G2 box; other site
1288394010708	Switch II region; other site
1288394010709	G3 box; other site
1288394010710	G4 box; other site
1288394010711	G5 box; other site
1288394010712	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1288394010713	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1288394010714	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1288394010715	TrkA-C domain; Region: TrkA_C; pfam02080
1288394010716	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1288394010717	TrkA-C domain; Region: TrkA_C; pfam02080
1288394010718	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1288394010719	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
1288394010720	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1288394010721	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1288394010722	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1288394010723	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1288394010724	ligand binding site [chemical binding]; other site
1288394010725	flexible hinge region; other site
1288394010726	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1288394010727	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
1288394010728	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1288394010729	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1288394010730	Ca binding site [ion binding]; other site
1288394010731	active site
1288394010732	catalytic site [active]
1288394010733	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1288394010734	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1288394010735	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1288394010736	dimer interface [polypeptide binding]; other site
1288394010737	PYR/PP interface [polypeptide binding]; other site
1288394010738	TPP binding site [chemical binding]; other site
1288394010739	substrate binding site [chemical binding]; other site
1288394010740	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1288394010741	Domain of unknown function; Region: EKR; pfam10371
1288394010742	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1288394010743	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394010744	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1288394010745	TPP-binding site [chemical binding]; other site
1288394010746	dimer interface [polypeptide binding]; other site
1288394010747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394010748	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394010749	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1288394010750	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394010751	motif II; other site
1288394010752	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
1288394010753	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
1288394010754	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
1288394010755	NAD(P) binding site [chemical binding]; other site
1288394010756	catalytic residues [active]
1288394010757	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
1288394010758	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
1288394010759	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
1288394010760	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394010761	inhibitor-cofactor binding pocket; inhibition site
1288394010762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394010763	catalytic residue [active]
1288394010764	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1288394010765	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1288394010766	glutamine binding [chemical binding]; other site
1288394010767	catalytic triad [active]
1288394010768	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1288394010769	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1288394010770	active site
1288394010771	HIGH motif; other site
1288394010772	dimer interface [polypeptide binding]; other site
1288394010773	KMSKS motif; other site
1288394010774	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1288394010775	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1288394010776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394010777	motif II; other site
1288394010778	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1288394010779	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1288394010780	substrate binding site [chemical binding]; other site
1288394010781	hexamer interface [polypeptide binding]; other site
1288394010782	metal binding site [ion binding]; metal-binding site
1288394010783	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1288394010784	AAA domain; Region: AAA_22; pfam13401
1288394010785	cell division protein DamX; Validated; Region: PRK10905
1288394010786	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1288394010787	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
1288394010788	active site
1288394010789	dimer interface [polypeptide binding]; other site
1288394010790	metal binding site [ion binding]; metal-binding site
1288394010791	shikimate kinase; Reviewed; Region: aroK; PRK00131
1288394010792	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1288394010793	ADP binding site [chemical binding]; other site
1288394010794	magnesium binding site [ion binding]; other site
1288394010795	putative shikimate binding site; other site
1288394010796	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
1288394010797	Secretin and TonB N terminus short domain; Region: STN; smart00965
1288394010798	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1288394010799	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1288394010800	Pilus assembly protein, PilP; Region: PilP; pfam04351
1288394010801	Pilus assembly protein, PilO; Region: PilO; pfam04350
1288394010802	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1288394010803	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1288394010804	Competence protein A; Region: Competence_A; pfam11104
1288394010805	Cell division protein FtsA; Region: FtsA; pfam14450
1288394010806	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
1288394010807	Transglycosylase; Region: Transgly; pfam00912
1288394010808	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1288394010809	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1288394010810	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394010811	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1288394010812	dimerization interface [polypeptide binding]; other site
1288394010813	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394010814	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394010815	dimerization interface [polypeptide binding]; other site
1288394010816	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394010817	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394010818	dimer interface [polypeptide binding]; other site
1288394010819	putative CheW interface [polypeptide binding]; other site
1288394010820	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
1288394010821	catalytic residues [active]
1288394010822	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1288394010823	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394010824	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394010825	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394010826	putative effector binding pocket; other site
1288394010827	dimerization interface [polypeptide binding]; other site
1288394010828	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1288394010829	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394010830	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
1288394010831	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
1288394010832	putative mechanosensitive channel protein; Provisional; Region: PRK10929
1288394010833	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
1288394010834	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394010835	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1288394010836	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1288394010837	active site
1288394010838	catalytic site [active]
1288394010839	Cache domain; Region: Cache_1; pfam02743
1288394010840	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394010841	dimerization interface [polypeptide binding]; other site
1288394010842	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394010843	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394010844	dimer interface [polypeptide binding]; other site
1288394010845	putative CheW interface [polypeptide binding]; other site
1288394010846	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
1288394010847	L-aspartate oxidase; Provisional; Region: PRK06175
1288394010848	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1288394010849	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
1288394010850	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1288394010851	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
1288394010852	D-subunit interface [polypeptide binding]; other site
1288394010853	Iron-sulfur protein interface; other site
1288394010854	proximal quinone binding site [chemical binding]; other site
1288394010855	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
1288394010856	C-subunit interface; other site
1288394010857	distal quinone binding site; other site
1288394010858	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394010859	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394010860	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394010861	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1288394010862	substrate binding pocket [chemical binding]; other site
1288394010863	membrane-bound complex binding site; other site
1288394010864	hinge residues; other site
1288394010865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1288394010866	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1288394010867	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1288394010868	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1288394010869	Thermostable hemolysin; Region: T_hemolysin; pfam12261
1288394010870	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_3; cd05914
1288394010871	AMP-binding enzyme; Region: AMP-binding; pfam00501
1288394010872	acyl-activating enzyme (AAE) consensus motif; other site
1288394010873	putative AMP binding site [chemical binding]; other site
1288394010874	putative active site [active]
1288394010875	putative CoA binding site [chemical binding]; other site
1288394010876	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1288394010877	heme binding pocket [chemical binding]; other site
1288394010878	heme ligand [chemical binding]; other site
1288394010879	short chain dehydrogenase; Provisional; Region: PRK09072
1288394010880	classical (c) SDRs; Region: SDR_c; cd05233
1288394010881	NAD(P) binding site [chemical binding]; other site
1288394010882	active site
1288394010883	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394010884	TPR repeat; Region: TPR_11; pfam13414
1288394010885	binding surface
1288394010886	TPR motif; other site
1288394010887	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
1288394010888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394010889	active site
1288394010890	phosphorylation site [posttranslational modification]
1288394010891	intermolecular recognition site; other site
1288394010892	dimerization interface [polypeptide binding]; other site
1288394010893	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394010894	DNA binding site [nucleotide binding]
1288394010895	sensor protein QseC; Provisional; Region: PRK10337
1288394010896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1288394010897	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394010898	ATP binding site [chemical binding]; other site
1288394010899	Mg2+ binding site [ion binding]; other site
1288394010900	G-X-G motif; other site
1288394010901	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
1288394010902	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
1288394010903	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1288394010904	active site
1288394010905	Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093
1288394010906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394
1288394010907	elongation factor P; Validated; Region: PRK00529
1288394010908	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1288394010909	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1288394010910	RNA binding site [nucleotide binding]; other site
1288394010911	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1288394010912	RNA binding site [nucleotide binding]; other site
1288394010913	Predicted membrane protein (DUF2238); Region: DUF2238; cl01464
1288394010914	Protein of unknown function (DUF3530); Region: DUF3530; pfam12048
1288394010915	glycerate dehydrogenase; Provisional; Region: PRK06932
1288394010916	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1288394010917	putative ligand binding site [chemical binding]; other site
1288394010918	putative NAD binding site [chemical binding]; other site
1288394010919	catalytic site [active]
1288394010920	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394010921	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394010922	metal binding site [ion binding]; metal-binding site
1288394010923	active site
1288394010924	I-site; other site
1288394010925	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1288394010926	dimer interface [polypeptide binding]; other site
1288394010927	FMN binding site [chemical binding]; other site
1288394010928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1288394010929	putative phosphatase; Provisional; Region: PRK11587
1288394010930	motif I; other site
1288394010931	active site
1288394010932	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394010933	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394010934	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1288394010935	dimerization interface [polypeptide binding]; other site
1288394010936	substrate binding pocket [chemical binding]; other site
1288394010937	PAS fold; Region: PAS_4; pfam08448
1288394010938	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394010939	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394010940	metal binding site [ion binding]; metal-binding site
1288394010941	active site
1288394010942	I-site; other site
1288394010943	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1288394010944	DNA-binding site [nucleotide binding]; DNA binding site
1288394010945	RNA-binding motif; other site
1288394010946	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
1288394010947	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394010948	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1288394010949	catalytic triad [active]
1288394010950	conserved cis-peptide bond; other site
1288394010951	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1288394010952	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
1288394010953	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1288394010954	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1288394010955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394010956	FeS/SAM binding site; other site
1288394010957	TRAM domain; Region: TRAM; pfam01938
1288394010958	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1288394010959	PhoH-like protein; Region: PhoH; pfam02562
1288394010960	metal-binding heat shock protein; Provisional; Region: PRK00016
1288394010961	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
1288394010962	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1288394010963	Transporter associated domain; Region: CorC_HlyC; smart01091
1288394010964	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1288394010965	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1288394010966	putative active site [active]
1288394010967	catalytic triad [active]
1288394010968	putative dimer interface [polypeptide binding]; other site
1288394010969	Protein of unknown function (DUF1451); Region: DUF1451; pfam07295
1288394010970	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1288394010971	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1288394010972	HIGH motif; other site
1288394010973	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1288394010974	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1288394010975	active site
1288394010976	KMSKS motif; other site
1288394010977	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1288394010978	tRNA binding surface [nucleotide binding]; other site
1288394010979	Lipopolysaccharide-assembly; Region: LptE; cl01125
1288394010980	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1288394010981	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1288394010982	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1288394010983	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1288394010984	active site
1288394010985	(T/H)XGH motif; other site
1288394010986	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1288394010987	rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246
1288394010988	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1288394010989	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1288394010990	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1288394010991	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1288394010992	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1288394010993	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1288394010994	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394010995	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394010996	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1288394010997	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1288394010998	Sporulation related domain; Region: SPOR; pfam05036
1288394010999	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1288394011000	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1288394011001	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1288394011002	hypothetical protein; Provisional; Region: PRK04998
1288394011003	lipoate-protein ligase B; Provisional; Region: PRK14342
1288394011004	lipoyl synthase; Provisional; Region: PRK05481
1288394011005	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1288394011006	FeS/SAM binding site; other site
1288394011007	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1288394011008	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394011009	Coenzyme A binding pocket [chemical binding]; other site
1288394011010	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1288394011011	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394011012	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
1288394011013	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394011014	Predicted acetyltransferase [General function prediction only]; Region: COG3153
1288394011015	Helix-Turn-Helix DNA binding domain of the Cfa transcription regulator; Region: HTH_Cfa; cd04789
1288394011016	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1288394011017	DNA binding residues [nucleotide binding]
1288394011018	putative dimer interface [polypeptide binding]; other site
1288394011019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394011020	S-adenosylmethionine binding site [chemical binding]; other site
1288394011021	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
1288394011022	DHH family; Region: DHH; pfam01368
1288394011023	DHHA1 domain; Region: DHHA1; pfam02272
1288394011024	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
1288394011025	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394011026	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1288394011027	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1288394011028	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1288394011029	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1288394011030	active site
1288394011031	Int/Topo IB signature motif; other site
1288394011032	flavodoxin FldB; Provisional; Region: PRK12359
1288394011033	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1288394011034	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1288394011035	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394011036	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1288394011037	L,D-transpeptidase; Provisional; Region: PRK10190
1288394011038	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1288394011039	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1288394011040	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1288394011041	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1288394011042	active site
1288394011043	TDP-binding site; other site
1288394011044	acceptor substrate-binding pocket; other site
1288394011045	homodimer interface [polypeptide binding]; other site
1288394011046	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1288394011047	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1288394011048	substrate binding pocket [chemical binding]; other site
1288394011049	active site
1288394011050	iron coordination sites [ion binding]; other site
1288394011051	Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207
1288394011052	Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141
1288394011053	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
1288394011054	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1288394011055	active site
1288394011056	nucleophile elbow; other site
1288394011057	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; Region: PGM_PMM_I; pfam02878
1288394011058	tetrathionate reductase subunit A; Provisional; Region: PRK14991
1288394011059	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
1288394011060	putative [Fe4-S4] binding site [ion binding]; other site
1288394011061	putative molybdopterin cofactor binding site [chemical binding]; other site
1288394011062	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
1288394011063	putative molybdopterin cofactor binding site; other site
1288394011064	tetrathionate reductase subunit C; Provisional; Region: PRK14992
1288394011065	tetrathionate reductase subunit B; Provisional; Region: PRK14993
1288394011066	4Fe-4S binding domain; Region: Fer4; pfam00037
1288394011067	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1288394011068	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394011069	dimer interface [polypeptide binding]; other site
1288394011070	phosphorylation site [posttranslational modification]
1288394011071	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394011072	ATP binding site [chemical binding]; other site
1288394011073	G-X-G motif; other site
1288394011074	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
1288394011075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394011076	active site
1288394011077	phosphorylation site [posttranslational modification]
1288394011078	intermolecular recognition site; other site
1288394011079	dimerization interface [polypeptide binding]; other site
1288394011080	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394011081	DNA binding residues [nucleotide binding]
1288394011082	dimerization interface [polypeptide binding]; other site
1288394011083	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1288394011084	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1288394011085	GAF domain; Region: GAF; pfam01590
1288394011086	Histidine kinase; Region: His_kinase; pfam06580
1288394011087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394011088	ATP binding site [chemical binding]; other site
1288394011089	Mg2+ binding site [ion binding]; other site
1288394011090	G-X-G motif; other site
1288394011091	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
1288394011092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394011093	active site
1288394011094	phosphorylation site [posttranslational modification]
1288394011095	intermolecular recognition site; other site
1288394011096	dimerization interface [polypeptide binding]; other site
1288394011097	LytTr DNA-binding domain; Region: LytTR; smart00850
1288394011098	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1288394011099	Carbon starvation protein CstA; Region: CstA; pfam02554
1288394011100	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1288394011101	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1288394011102	active site pocket [active]
1288394011103	oxyanion hole [active]
1288394011104	catalytic triad [active]
1288394011105	active site nucleophile [active]
1288394011106	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1288394011107	Class II fumarases; Region: Fumarase_classII; cd01362
1288394011108	active site
1288394011109	tetramer interface [polypeptide binding]; other site
1288394011110	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
1288394011111	Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553
1288394011112	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1288394011113	heme-binding site [chemical binding]; other site
1288394011114	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394011115	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394011116	metal binding site [ion binding]; metal-binding site
1288394011117	active site
1288394011118	I-site; other site
1288394011119	potential frameshift: common BLAST hit: gi|117619837|ref|YP_857789.1| major facilitator transporter
1288394011120	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1288394011121	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1288394011122	RNase E interface [polypeptide binding]; other site
1288394011123	trimer interface [polypeptide binding]; other site
1288394011124	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1288394011125	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1288394011126	RNase E interface [polypeptide binding]; other site
1288394011127	trimer interface [polypeptide binding]; other site
1288394011128	active site
1288394011129	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1288394011130	putative nucleic acid binding region [nucleotide binding]; other site
1288394011131	G-X-X-G motif; other site
1288394011132	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1288394011133	RNA binding site [nucleotide binding]; other site
1288394011134	domain interface; other site
1288394011135	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1288394011136	16S/18S rRNA binding site [nucleotide binding]; other site
1288394011137	S13e-L30e interaction site [polypeptide binding]; other site
1288394011138	25S rRNA binding site [nucleotide binding]; other site
1288394011139	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
1288394011140	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1288394011141	RNA binding site [nucleotide binding]; other site
1288394011142	active site
1288394011143	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1288394011144	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1288394011145	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1288394011146	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
1288394011147	translation initiation factor IF-2; Region: IF-2; TIGR00487
1288394011148	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1288394011149	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1288394011150	G1 box; other site
1288394011151	putative GEF interaction site [polypeptide binding]; other site
1288394011152	GTP/Mg2+ binding site [chemical binding]; other site
1288394011153	Switch I region; other site
1288394011154	G2 box; other site
1288394011155	G3 box; other site
1288394011156	Switch II region; other site
1288394011157	G4 box; other site
1288394011158	G5 box; other site
1288394011159	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1288394011160	Translation-initiation factor 2; Region: IF-2; pfam11987
1288394011161	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1288394011162	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1288394011163	NusA N-terminal domain; Region: NusA_N; pfam08529
1288394011164	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1288394011165	RNA binding site [nucleotide binding]; other site
1288394011166	homodimer interface [polypeptide binding]; other site
1288394011167	NusA-like KH domain; Region: KH_5; pfam13184
1288394011168	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1288394011169	G-X-X-G motif; other site
1288394011170	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1288394011171	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1288394011172	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1288394011173	Sm and related proteins; Region: Sm_like; cl00259
1288394011174	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1288394011175	putative oligomer interface [polypeptide binding]; other site
1288394011176	putative RNA binding site [nucleotide binding]; other site
1288394011177	Preprotein translocase SecG subunit; Region: SecG; pfam03840
1288394011178	triosephosphate isomerase; Provisional; Region: PRK14567
1288394011179	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1288394011180	substrate binding site [chemical binding]; other site
1288394011181	dimer interface [polypeptide binding]; other site
1288394011182	catalytic triad [active]
1288394011183	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
1288394011184	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1288394011185	active site
1288394011186	substrate binding site [chemical binding]; other site
1288394011187	metal binding site [ion binding]; metal-binding site
1288394011188	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1288394011189	dihydropteroate synthase; Region: DHPS; TIGR01496
1288394011190	substrate binding pocket [chemical binding]; other site
1288394011191	dimer interface [polypeptide binding]; other site
1288394011192	inhibitor binding site; inhibition site
1288394011193	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
1288394011194	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394011195	Walker A motif; other site
1288394011196	ATP binding site [chemical binding]; other site
1288394011197	Walker B motif; other site
1288394011198	arginine finger; other site
1288394011199	Peptidase family M41; Region: Peptidase_M41; pfam01434
1288394011200	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1288394011201	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394011202	S-adenosylmethionine binding site [chemical binding]; other site
1288394011203	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
1288394011204	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1288394011205	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1288394011206	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1288394011207	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
1288394011208	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1288394011209	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394011210	ligand binding site [chemical binding]; other site
1288394011211	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1288394011212	flagellar motor protein MotP; Reviewed; Region: PRK06743
1288394011213	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1288394011214	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1288394011215	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1288394011216	substrate binding pocket [chemical binding]; other site
1288394011217	chain length determination region; other site
1288394011218	substrate-Mg2+ binding site; other site
1288394011219	catalytic residues [active]
1288394011220	aspartate-rich region 1; other site
1288394011221	active site lid residues [active]
1288394011222	aspartate-rich region 2; other site
1288394011223	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1288394011224	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1288394011225	TPP-binding site; other site
1288394011226	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1288394011227	PYR/PP interface [polypeptide binding]; other site
1288394011228	dimer interface [polypeptide binding]; other site
1288394011229	TPP binding site [chemical binding]; other site
1288394011230	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1288394011231	dipeptide transporter; Provisional; Region: PRK10913
1288394011232	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394011233	dimer interface [polypeptide binding]; other site
1288394011234	conserved gate region; other site
1288394011235	putative PBP binding loops; other site
1288394011236	ABC-ATPase subunit interface; other site
1288394011237	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1288394011238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394011239	dimer interface [polypeptide binding]; other site
1288394011240	conserved gate region; other site
1288394011241	putative PBP binding loops; other site
1288394011242	ABC-ATPase subunit interface; other site
1288394011243	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
1288394011244	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1288394011245	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1288394011246	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394011247	Walker A/P-loop; other site
1288394011248	ATP binding site [chemical binding]; other site
1288394011249	Q-loop/lid; other site
1288394011250	ABC transporter signature motif; other site
1288394011251	Walker B; other site
1288394011252	D-loop; other site
1288394011253	H-loop/switch region; other site
1288394011254	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1288394011255	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394011256	Walker A/P-loop; other site
1288394011257	ATP binding site [chemical binding]; other site
1288394011258	Q-loop/lid; other site
1288394011259	ABC transporter signature motif; other site
1288394011260	Walker B; other site
1288394011261	D-loop; other site
1288394011262	H-loop/switch region; other site
1288394011263	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1288394011264	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1288394011265	tetramer interfaces [polypeptide binding]; other site
1288394011266	binuclear metal-binding site [ion binding]; other site
1288394011267	thiamine monophosphate kinase; Provisional; Region: PRK05731
1288394011268	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1288394011269	ATP binding site [chemical binding]; other site
1288394011270	dimerization interface [polypeptide binding]; other site
1288394011271	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1288394011272	putative RNA binding site [nucleotide binding]; other site
1288394011273	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1288394011274	homopentamer interface [polypeptide binding]; other site
1288394011275	active site
1288394011276	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
1288394011277	cleavage site
1288394011278	active site
1288394011279	substrate binding sites [chemical binding]; other site
1288394011280	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1288394011281	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1288394011282	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1288394011283	dimerization interface [polypeptide binding]; other site
1288394011284	active site
1288394011285	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1288394011286	Lumazine binding domain; Region: Lum_binding; pfam00677
1288394011287	Lumazine binding domain; Region: Lum_binding; pfam00677
1288394011288	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
1288394011289	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1288394011290	catalytic motif [active]
1288394011291	Zn binding site [ion binding]; other site
1288394011292	RibD C-terminal domain; Region: RibD_C; cl17279
1288394011293	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1288394011294	ATP cone domain; Region: ATP-cone; pfam03477
1288394011295	NIPSNAP; Region: NIPSNAP; pfam07978
1288394011296	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1288394011297	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1288394011298	dimer interface [polypeptide binding]; other site
1288394011299	active site
1288394011300	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1288394011301	folate binding site [chemical binding]; other site
1288394011302	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1288394011303	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1288394011304	PAS fold; Region: PAS_4; pfam08448
1288394011305	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394011306	putative active site [active]
1288394011307	heme pocket [chemical binding]; other site
1288394011308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394011309	PAS domain; Region: PAS_9; pfam13426
1288394011310	putative active site [active]
1288394011311	heme pocket [chemical binding]; other site
1288394011312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394011313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394011314	metal binding site [ion binding]; metal-binding site
1288394011315	active site
1288394011316	I-site; other site
1288394011317	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394011318	acetyl-CoA synthetase; Provisional; Region: PRK00174
1288394011319	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1288394011320	active site
1288394011321	CoA binding site [chemical binding]; other site
1288394011322	acyl-activating enzyme (AAE) consensus motif; other site
1288394011323	AMP binding site [chemical binding]; other site
1288394011324	acetate binding site [chemical binding]; other site
1288394011325	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1288394011326	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1288394011327	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1288394011328	active site
1288394011329	trimer interface [polypeptide binding]; other site
1288394011330	dimer interface [polypeptide binding]; other site
1288394011331	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1288394011332	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1288394011333	carboxyltransferase (CT) interaction site; other site
1288394011334	biotinylation site [posttranslational modification]; other site
1288394011335	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1288394011336	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1288394011337	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1288394011338	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1288394011339	Protein of unknown function (DUF997); Region: DUF997; cl01614
1288394011340	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
1288394011341	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1288394011342	Na binding site [ion binding]; other site
1288394011343	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394011344	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1288394011345	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1288394011346	active site turn [active]
1288394011347	phosphorylation site [posttranslational modification]
1288394011348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394011349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394011350	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1288394011351	putative effector binding pocket; other site
1288394011352	dimerization interface [polypeptide binding]; other site
1288394011353	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1288394011354	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1288394011355	putative NAD(P) binding site [chemical binding]; other site
1288394011356	dimer interface [polypeptide binding]; other site
1288394011357	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1288394011358	Methyltransferase domain; Region: Methyltransf_18; pfam12847
1288394011359	S-adenosylmethionine binding site [chemical binding]; other site
1288394011360	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1288394011361	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1288394011362	dimerization interface [polypeptide binding]; other site
1288394011363	NAD binding site [chemical binding]; other site
1288394011364	ligand binding site [chemical binding]; other site
1288394011365	catalytic site [active]
1288394011366	maltose O-acetyltransferase; Provisional; Region: PRK10092
1288394011367	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1288394011368	active site
1288394011369	substrate binding site [chemical binding]; other site
1288394011370	trimer interface [polypeptide binding]; other site
1288394011371	CoA binding site [chemical binding]; other site
1288394011372	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1288394011373	putative FMN binding site [chemical binding]; other site
1288394011374	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1288394011375	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1288394011376	active site
1288394011377	FMN binding site [chemical binding]; other site
1288394011378	2,4-decadienoyl-CoA binding site; other site
1288394011379	catalytic residue [active]
1288394011380	4Fe-4S cluster binding site [ion binding]; other site
1288394011381	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1288394011382	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394011383	protease 4; Provisional; Region: PRK10949
1288394011384	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1288394011385	tandem repeat interface [polypeptide binding]; other site
1288394011386	oligomer interface [polypeptide binding]; other site
1288394011387	active site residues [active]
1288394011388	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1288394011389	tandem repeat interface [polypeptide binding]; other site
1288394011390	oligomer interface [polypeptide binding]; other site
1288394011391	active site residues [active]
1288394011392	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1288394011393	nudix motif; other site
1288394011394	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
1288394011395	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1288394011396	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1288394011397	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1288394011398	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
1288394011399	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
1288394011400	active site
1288394011401	homodimer interface [polypeptide binding]; other site
1288394011402	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1288394011403	Cache domain; Region: Cache_1; pfam02743
1288394011404	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394011405	dimerization interface [polypeptide binding]; other site
1288394011406	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394011407	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394011408	dimer interface [polypeptide binding]; other site
1288394011409	putative CheW interface [polypeptide binding]; other site
1288394011410	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1288394011411	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1288394011412	RF-1 domain; Region: RF-1; pfam00472
1288394011413	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1288394011414	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1288394011415	dimer interface [polypeptide binding]; other site
1288394011416	putative anticodon binding site; other site
1288394011417	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1288394011418	motif 1; other site
1288394011419	active site
1288394011420	motif 2; other site
1288394011421	motif 3; other site
1288394011422	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1288394011423	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
1288394011424	Flavodoxin; Region: Flavodoxin_1; pfam00258
1288394011425	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1288394011426	FAD binding pocket [chemical binding]; other site
1288394011427	FAD binding motif [chemical binding]; other site
1288394011428	catalytic residues [active]
1288394011429	NAD binding pocket [chemical binding]; other site
1288394011430	phosphate binding motif [ion binding]; other site
1288394011431	beta-alpha-beta structure motif; other site
1288394011432	sulfite reductase subunit beta; Provisional; Region: PRK13504
1288394011433	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1288394011434	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1288394011435	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1288394011436	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1288394011437	Active Sites [active]
1288394011438	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
1288394011439	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1288394011440	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
1288394011441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394011442	dimer interface [polypeptide binding]; other site
1288394011443	conserved gate region; other site
1288394011444	putative PBP binding loops; other site
1288394011445	ABC-ATPase subunit interface; other site
1288394011446	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1288394011447	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1288394011448	Walker A/P-loop; other site
1288394011449	ATP binding site [chemical binding]; other site
1288394011450	Q-loop/lid; other site
1288394011451	ABC transporter signature motif; other site
1288394011452	Walker B; other site
1288394011453	D-loop; other site
1288394011454	H-loop/switch region; other site
1288394011455	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
1288394011456	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1288394011457	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1288394011458	folate binding site [chemical binding]; other site
1288394011459	NADP+ binding site [chemical binding]; other site
1288394011460	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1288394011461	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1288394011462	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1288394011463	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
1288394011464	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1288394011465	MPT binding site; other site
1288394011466	trimer interface [polypeptide binding]; other site
1288394011467	Protein of unknown function (DUF2541); Region: DUF2541; cl08090
1288394011468	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
1288394011469	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1288394011470	dimer interface [polypeptide binding]; other site
1288394011471	active site
1288394011472	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1288394011473	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
1288394011474	NAD(P) binding site [chemical binding]; other site
1288394011475	homotetramer interface [polypeptide binding]; other site
1288394011476	homodimer interface [polypeptide binding]; other site
1288394011477	active site
1288394011478	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
1288394011479	putative active site 1 [active]
1288394011480	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
1288394011481	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1288394011482	dimer interface [polypeptide binding]; other site
1288394011483	active site
1288394011484	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
1288394011485	Predicted exporter [General function prediction only]; Region: COG4258
1288394011486	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1288394011487	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1288394011488	active site
1288394011489	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1288394011490	active sites [active]
1288394011491	tetramer interface [polypeptide binding]; other site
1288394011492	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1288394011493	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1288394011494	Ligand binding site; other site
1288394011495	Putative Catalytic site; other site
1288394011496	DXD motif; other site
1288394011497	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1288394011498	putative acyl-acceptor binding pocket; other site
1288394011499	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1288394011500	active site 2 [active]
1288394011501	active site 1 [active]
1288394011502	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1288394011503	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1288394011504	acyl-activating enzyme (AAE) consensus motif; other site
1288394011505	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1288394011506	AMP binding site [chemical binding]; other site
1288394011507	active site
1288394011508	acyl-activating enzyme (AAE) consensus motif; other site
1288394011509	CoA binding site [chemical binding]; other site
1288394011510	Predicted membrane protein [Function unknown]; Region: COG4648
1288394011511	acyl carrier protein; Provisional; Region: PRK05350
1288394011512	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1288394011513	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1288394011514	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1288394011515	putative acyl-acceptor binding pocket; other site
1288394011516	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
1288394011517	O-methyltransferase; Region: Methyltransf_2; pfam00891
1288394011518	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1288394011519	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1288394011520	active site
1288394011521	substrate binding site [chemical binding]; other site
1288394011522	Mg2+ binding site [ion binding]; other site
1288394011523	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
1288394011524	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1288394011525	active site
1288394011526	zinc binding site [ion binding]; other site
1288394011527	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1288394011528	putative kinase; Provisional; Region: PRK09954
1288394011529	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394011530	putative DNA binding site [nucleotide binding]; other site
1288394011531	putative Zn2+ binding site [ion binding]; other site
1288394011532	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1288394011533	substrate binding site [chemical binding]; other site
1288394011534	ATP binding site [chemical binding]; other site
1288394011535	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1288394011536	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1288394011537	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1288394011538	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1288394011539	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1288394011540	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1288394011541	Walker A/P-loop; other site
1288394011542	ATP binding site [chemical binding]; other site
1288394011543	Q-loop/lid; other site
1288394011544	ABC transporter signature motif; other site
1288394011545	Walker B; other site
1288394011546	D-loop; other site
1288394011547	H-loop/switch region; other site
1288394011548	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1288394011549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394011550	dimer interface [polypeptide binding]; other site
1288394011551	conserved gate region; other site
1288394011552	putative PBP binding loops; other site
1288394011553	ABC-ATPase subunit interface; other site
1288394011554	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1288394011555	NMT1-like family; Region: NMT1_2; pfam13379
1288394011556	ANTAR domain; Region: ANTAR; pfam03861
1288394011557	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1288394011558	active site
1288394011559	SAM binding site [chemical binding]; other site
1288394011560	homodimer interface [polypeptide binding]; other site
1288394011561	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1288394011562	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1288394011563	[4Fe-4S] binding site [ion binding]; other site
1288394011564	molybdopterin cofactor binding site; other site
1288394011565	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1288394011566	molybdopterin cofactor binding site; other site
1288394011567	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1288394011568	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1288394011569	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1288394011570	Ligand Binding Site [chemical binding]; other site
1288394011571	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
1288394011572	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1288394011573	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1288394011574	putative catalytic cysteine [active]
1288394011575	gamma-glutamyl kinase; Provisional; Region: PRK05429
1288394011576	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1288394011577	nucleotide binding site [chemical binding]; other site
1288394011578	homotetrameric interface [polypeptide binding]; other site
1288394011579	putative phosphate binding site [ion binding]; other site
1288394011580	putative allosteric binding site; other site
1288394011581	PUA domain; Region: PUA; pfam01472
1288394011582	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
1288394011583	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
1288394011584	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394011585	active site
1288394011586	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
1288394011587	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
1288394011588	metal binding site [ion binding]; metal-binding site
1288394011589	dimer interface [polypeptide binding]; other site
1288394011590	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1288394011591	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394011592	Walker A/P-loop; other site
1288394011593	ATP binding site [chemical binding]; other site
1288394011594	Q-loop/lid; other site
1288394011595	ABC transporter signature motif; other site
1288394011596	Walker B; other site
1288394011597	D-loop; other site
1288394011598	H-loop/switch region; other site
1288394011599	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1288394011600	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1288394011601	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1288394011602	Walker A/P-loop; other site
1288394011603	ATP binding site [chemical binding]; other site
1288394011604	Q-loop/lid; other site
1288394011605	ABC transporter signature motif; other site
1288394011606	Walker B; other site
1288394011607	D-loop; other site
1288394011608	H-loop/switch region; other site
1288394011609	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1288394011610	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1288394011611	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1288394011612	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1288394011613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394011614	dimer interface [polypeptide binding]; other site
1288394011615	conserved gate region; other site
1288394011616	putative PBP binding loops; other site
1288394011617	ABC-ATPase subunit interface; other site
1288394011618	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1288394011619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394011620	dimer interface [polypeptide binding]; other site
1288394011621	conserved gate region; other site
1288394011622	putative PBP binding loops; other site
1288394011623	ABC-ATPase subunit interface; other site
1288394011624	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1288394011625	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1288394011626	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1288394011627	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1288394011628	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
1288394011629	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1288394011630	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1288394011631	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1288394011632	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1288394011633	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1288394011634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1288394011635	binding surface
1288394011636	TPR motif; other site
1288394011637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394011638	binding surface
1288394011639	TPR motif; other site
1288394011640	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
1288394011641	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1288394011642	active site
1288394011643	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1288394011644	Chitinase C; Region: ChiC; pfam06483
1288394011645	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
1288394011646	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1288394011647	ligand binding site [chemical binding]; other site
1288394011648	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1288394011649	generic binding surface II; other site
1288394011650	generic binding surface I; other site
1288394011651	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1288394011652	putative catalytic site [active]
1288394011653	putative metal binding site [ion binding]; other site
1288394011654	putative phosphate binding site [ion binding]; other site
1288394011655	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1288394011656	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1288394011657	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1288394011658	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1288394011659	HIGH motif; other site
1288394011660	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1288394011661	active site
1288394011662	KMSKS motif; other site
1288394011663	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394011664	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394011665	dimerization interface [polypeptide binding]; other site
1288394011666	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394011667	dimer interface [polypeptide binding]; other site
1288394011668	putative CheW interface [polypeptide binding]; other site
1288394011669	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1288394011670	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1288394011671	DNA-binding site [nucleotide binding]; DNA binding site
1288394011672	RNA-binding motif; other site
1288394011673	potential protein location (hypothetical protein AHML_18380 [Aeromonas hydrophila ML09-119]) that overlaps RNA (tRNA-G)
1288394011674	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1288394011675	catalytic site [active]
1288394011676	putative active site [active]
1288394011677	putative substrate binding site [chemical binding]; other site
1288394011678	dimer interface [polypeptide binding]; other site
1288394011679	GTPase RsgA; Reviewed; Region: PRK12288
1288394011680	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1288394011681	RNA binding site [nucleotide binding]; other site
1288394011682	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1288394011683	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1288394011684	GTP/Mg2+ binding site [chemical binding]; other site
1288394011685	G4 box; other site
1288394011686	G5 box; other site
1288394011687	G1 box; other site
1288394011688	Switch I region; other site
1288394011689	G2 box; other site
1288394011690	G3 box; other site
1288394011691	Switch II region; other site
1288394011692	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
1288394011693	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
1288394011694	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
1288394011695	PAS fold; Region: PAS_4; pfam08448
1288394011696	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394011697	PAS domain; Region: PAS_9; pfam13426
1288394011698	putative active site [active]
1288394011699	heme pocket [chemical binding]; other site
1288394011700	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394011701	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394011702	metal binding site [ion binding]; metal-binding site
1288394011703	active site
1288394011704	I-site; other site
1288394011705	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394011706	RNase E inhibitor protein; Provisional; Region: PRK11191
1288394011707	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
1288394011708	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1288394011709	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1288394011710	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1288394011711	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394011712	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1288394011713	ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; Region: ABCC_MRP_domain1; cd03250
1288394011714	Walker A/P-loop; other site
1288394011715	ATP binding site [chemical binding]; other site
1288394011716	Q-loop/lid; other site
1288394011717	ABC transporter signature motif; other site
1288394011718	Walker B; other site
1288394011719	D-loop; other site
1288394011720	H-loop/switch region; other site
1288394011721	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
1288394011722	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394011723	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394011724	Walker A/P-loop; other site
1288394011725	ATP binding site [chemical binding]; other site
1288394011726	Q-loop/lid; other site
1288394011727	ABC transporter signature motif; other site
1288394011728	Walker B; other site
1288394011729	D-loop; other site
1288394011730	H-loop/switch region; other site
1288394011731	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
1288394011732	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
1288394011733	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1288394011734	active site
1288394011735	catalytic residues [active]
1288394011736	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1288394011737	active site residue [active]
1288394011738	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1288394011739	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1288394011740	active site residue [active]
1288394011741	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1288394011742	active site residue [active]
1288394011743	glutaminase; Provisional; Region: PRK00971
1288394011744	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1288394011745	hypothetical protein; Provisional; Region: PRK11702
1288394011746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394011747	S-adenosylmethionine binding site [chemical binding]; other site
1288394011748	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1288394011749	metal binding site [ion binding]; metal-binding site
1288394011750	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1288394011751	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394011752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394011753	homodimer interface [polypeptide binding]; other site
1288394011754	catalytic residue [active]
1288394011755	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
1288394011756	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394011757	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1288394011758	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1288394011759	putative NAD(P) binding site [chemical binding]; other site
1288394011760	putative active site [active]
1288394011761	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1288394011762	FtsX-like permease family; Region: FtsX; pfam02687
1288394011763	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1288394011764	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1288394011765	Walker A/P-loop; other site
1288394011766	ATP binding site [chemical binding]; other site
1288394011767	Q-loop/lid; other site
1288394011768	ABC transporter signature motif; other site
1288394011769	Walker B; other site
1288394011770	D-loop; other site
1288394011771	H-loop/switch region; other site
1288394011772	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1288394011773	active site
1288394011774	catalytic triad [active]
1288394011775	oxyanion hole [active]
1288394011776	switch loop; other site
1288394011777	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1288394011778	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1288394011779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394011780	active site
1288394011781	phosphorylation site [posttranslational modification]
1288394011782	intermolecular recognition site; other site
1288394011783	dimerization interface [polypeptide binding]; other site
1288394011784	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1288394011785	VCBS repeat; Region: VCBS_repeat; TIGR01965
1288394011786	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1288394011787	VCBS repeat; Region: VCBS_repeat; TIGR01965
1288394011788	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
1288394011789	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1288394011790	metal ion-dependent adhesion site (MIDAS); other site
1288394011791	putative transporter; Validated; Region: PRK03818
1288394011792	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
1288394011793	TrkA-C domain; Region: TrkA_C; pfam02080
1288394011794	TrkA-C domain; Region: TrkA_C; pfam02080
1288394011795	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
1288394011796	hemolysin; Provisional; Region: PRK15087
1288394011797	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1288394011798	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1288394011799	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394011800	catalytic residue [active]
1288394011801	intracellular septation protein A; Reviewed; Region: PRK00259
1288394011802	YciI-like protein; Reviewed; Region: PRK11370
1288394011803	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1288394011804	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1288394011805	active site
1288394011806	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1288394011807	Helix-hairpin-helix motif; Region: HHH; pfam00633
1288394011808	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1288394011809	active site
1288394011810	tetramer interface; other site
1288394011811	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394011812	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394011813	putative substrate translocation pore; other site
1288394011814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394011815	active site
1288394011816	response regulator of RpoS; Provisional; Region: PRK10693
1288394011817	phosphorylation site [posttranslational modification]
1288394011818	intermolecular recognition site; other site
1288394011819	dimerization interface [polypeptide binding]; other site
1288394011820	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1288394011821	primosomal protein DnaI; Provisional; Region: PRK02854
1288394011822	putative replication protein; Provisional; Region: PRK12377
1288394011823	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394011824	Walker A motif; other site
1288394011825	ATP binding site [chemical binding]; other site
1288394011826	Walker B motif; other site
1288394011827	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1288394011828	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1288394011829	NAD(P) binding site [chemical binding]; other site
1288394011830	putative active site [active]
1288394011831	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1288394011832	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1288394011833	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1288394011834	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1288394011835	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1288394011836	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1288394011837	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394011838	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394011839	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1288394011840	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
1288394011841	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1288394011842	FMN binding site [chemical binding]; other site
1288394011843	active site
1288394011844	catalytic residues [active]
1288394011845	substrate binding site [chemical binding]; other site
1288394011846	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
1288394011847	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
1288394011848	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394011849	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
1288394011850	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
1288394011851	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1288394011852	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1288394011853	Cl- selectivity filter; other site
1288394011854	Cl- binding residues [ion binding]; other site
1288394011855	pore gating glutamate residue; other site
1288394011856	dimer interface [polypeptide binding]; other site
1288394011857	H+/Cl- coupling transport residue; other site
1288394011858	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1288394011859	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394011860	inhibitor-cofactor binding pocket; inhibition site
1288394011861	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394011862	catalytic residue [active]
1288394011863	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1288394011864	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1288394011865	active site
1288394011866	Protein of unknown function (DUF2937); Region: DUF2937; pfam11157
1288394011867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394011868	active site
1288394011869	phosphorylation site [posttranslational modification]
1288394011870	intermolecular recognition site; other site
1288394011871	Domain of unknown function (DUF3369); Region: DUF3369; pfam11849
1288394011872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394011873	Zn2+ binding site [ion binding]; other site
1288394011874	Mg2+ binding site [ion binding]; other site
1288394011875	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394011876	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394011877	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
1288394011878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1288394011879	dimerization interface [polypeptide binding]; other site
1288394011880	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1288394011881	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1288394011882	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1288394011883	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394011884	putative metal binding site [ion binding]; other site
1288394011885	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
1288394011886	Transglycosylase; Region: Transgly; pfam00912
1288394011887	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1288394011888	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
1288394011889	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394011890	ATP binding site [chemical binding]; other site
1288394011891	putative Mg++ binding site [ion binding]; other site
1288394011892	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394011893	nucleotide binding region [chemical binding]; other site
1288394011894	ATP-binding site [chemical binding]; other site
1288394011895	Helicase associated domain (HA2); Region: HA2; cl04503
1288394011896	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1288394011897	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1288394011898	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1288394011899	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1288394011900	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1288394011901	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
1288394011902	active site
1288394011903	KMSKS motif; other site
1288394011904	KMSKS motif; other site
1288394011905	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
1288394011906	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1288394011907	active site
1288394011908	NTP binding site [chemical binding]; other site
1288394011909	metal binding triad [ion binding]; metal-binding site
1288394011910	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1288394011911	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
1288394011912	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1288394011913	catalytic center binding site [active]
1288394011914	ATP binding site [chemical binding]; other site
1288394011915	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1288394011916	oligomerization interface [polypeptide binding]; other site
1288394011917	active site
1288394011918	metal binding site [ion binding]; metal-binding site
1288394011919	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1288394011920	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1288394011921	active site
1288394011922	ATP-binding site [chemical binding]; other site
1288394011923	pantoate-binding site; other site
1288394011924	HXXH motif; other site
1288394011925	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1288394011926	active site residue [active]
1288394011927	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1288394011928	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1288394011929	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
1288394011930	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
1288394011931	inner membrane transport permease; Provisional; Region: PRK15066
1288394011932	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1288394011933	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1288394011934	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1288394011935	Walker A/P-loop; other site
1288394011936	ATP binding site [chemical binding]; other site
1288394011937	Q-loop/lid; other site
1288394011938	ABC transporter signature motif; other site
1288394011939	Walker B; other site
1288394011940	D-loop; other site
1288394011941	H-loop/switch region; other site
1288394011942	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394011943	active site
1288394011944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394011945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394011946	aromatic acid decarboxylase; Validated; Region: PRK05920
1288394011947	Flavoprotein; Region: Flavoprotein; pfam02441
1288394011948	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
1288394011949	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1288394011950	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1288394011951	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1288394011952	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1288394011953	dimer interface [polypeptide binding]; other site
1288394011954	substrate binding site [chemical binding]; other site
1288394011955	metal binding sites [ion binding]; metal-binding site
1288394011956	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
1288394011957	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
1288394011958	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1288394011959	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1288394011960	Walker A/P-loop; other site
1288394011961	ATP binding site [chemical binding]; other site
1288394011962	Q-loop/lid; other site
1288394011963	ABC transporter signature motif; other site
1288394011964	Walker B; other site
1288394011965	D-loop; other site
1288394011966	H-loop/switch region; other site
1288394011967	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1288394011968	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1288394011969	FtsX-like permease family; Region: FtsX; pfam02687
1288394011970	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
1288394011971	TIGR03899 family protein; Region: TIGR03899
1288394011972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394011973	PAS fold; Region: PAS_3; pfam08447
1288394011974	putative active site [active]
1288394011975	heme pocket [chemical binding]; other site
1288394011976	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394011977	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394011978	dimer interface [polypeptide binding]; other site
1288394011979	putative CheW interface [polypeptide binding]; other site
1288394011980	WYL domain; Region: WYL; pfam13280
1288394011981	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1288394011982	ligand-binding site [chemical binding]; other site
1288394011983	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1288394011984	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1288394011985	TrkA-C domain; Region: TrkA_C; pfam02080
1288394011986	TrkA-C domain; Region: TrkA_C; pfam02080
1288394011987	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1288394011988	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
1288394011989	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1288394011990	CysD dimerization site [polypeptide binding]; other site
1288394011991	G1 box; other site
1288394011992	putative GEF interaction site [polypeptide binding]; other site
1288394011993	GTP/Mg2+ binding site [chemical binding]; other site
1288394011994	Switch I region; other site
1288394011995	G2 box; other site
1288394011996	G3 box; other site
1288394011997	Switch II region; other site
1288394011998	G4 box; other site
1288394011999	G5 box; other site
1288394012000	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1288394012001	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1288394012002	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1288394012003	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1288394012004	Active Sites [active]
1288394012005	siroheme synthase; Provisional; Region: cysG; PRK10637
1288394012006	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1288394012007	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1288394012008	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1288394012009	active site
1288394012010	SAM binding site [chemical binding]; other site
1288394012011	homodimer interface [polypeptide binding]; other site
1288394012012	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1288394012013	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1288394012014	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1288394012015	FOG: CBS domain [General function prediction only]; Region: COG0517
1288394012016	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1288394012017	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1288394012018	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394012019	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394012020	ABC transporter; Region: ABC_tran_2; pfam12848
1288394012021	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1288394012022	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
1288394012023	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1288394012024	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394012025	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394012026	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475
1288394012027	putative effector binding pocket; other site
1288394012028	putative dimerization interface [polypeptide binding]; other site
1288394012029	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1288394012030	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
1288394012031	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
1288394012032	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1288394012033	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394012034	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1288394012035	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1288394012036	catalytic site [active]
1288394012037	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1288394012038	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
1288394012039	Na binding site [ion binding]; other site
1288394012040	L,D-transpeptidase; Provisional; Region: PRK10190
1288394012041	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1288394012042	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1288394012043	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394012044	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1288394012045	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1288394012046	propionate/acetate kinase; Provisional; Region: PRK12379
1288394012047	Domain of unknown function (DUF386); Region: DUF386; cl01047
1288394012048	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1288394012049	putative acyl-acceptor binding pocket; other site
1288394012050	multicopper oxidase; Provisional; Region: PRK10965
1288394012051	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1288394012052	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1288394012053	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1288394012054	aspartate racemase; Region: asp_race; TIGR00035
1288394012055	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394012056	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1288394012057	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1288394012058	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394012059	DNA-binding site [nucleotide binding]; DNA binding site
1288394012060	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394012061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394012062	homodimer interface [polypeptide binding]; other site
1288394012063	catalytic residue [active]
1288394012064	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
1288394012065	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1288394012066	Na2 binding site [ion binding]; other site
1288394012067	putative substrate binding site 1 [chemical binding]; other site
1288394012068	Na binding site 1 [ion binding]; other site
1288394012069	putative substrate binding site 2 [chemical binding]; other site
1288394012070	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394012071	substrate binding pocket [chemical binding]; other site
1288394012072	membrane-bound complex binding site; other site
1288394012073	hinge residues; other site
1288394012074	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1288394012075	Na2 binding site [ion binding]; other site
1288394012076	putative substrate binding site 1 [chemical binding]; other site
1288394012077	Na binding site 1 [ion binding]; other site
1288394012078	putative substrate binding site 2 [chemical binding]; other site
1288394012079	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1288394012080	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1288394012081	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1288394012082	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
1288394012083	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
1288394012084	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394012085	active site
1288394012086	motif I; other site
1288394012087	motif II; other site
1288394012088	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394012089	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1288394012090	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394012091	putative substrate translocation pore; other site
1288394012092	Predicted transcriptional regulator [Transcription]; Region: COG2345
1288394012093	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1288394012094	putative DNA binding site [nucleotide binding]; other site
1288394012095	putative Zn2+ binding site [ion binding]; other site
1288394012096	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1288394012097	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394012098	putative DNA binding site [nucleotide binding]; other site
1288394012099	putative Zn2+ binding site [ion binding]; other site
1288394012100	AsnC family; Region: AsnC_trans_reg; pfam01037
1288394012101	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
1288394012102	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1288394012103	MarR family; Region: MarR; pfam01047
1288394012104	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1288394012105	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1288394012106	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1288394012107	NAD(P) binding site [chemical binding]; other site
1288394012108	substrate binding site [chemical binding]; other site
1288394012109	dimer interface [polypeptide binding]; other site
1288394012110	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678
1288394012111	nudix motif; other site
1288394012112	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1288394012113	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1288394012114	Chromate transporter; Region: Chromate_transp; pfam02417
1288394012115	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1288394012116	SelR domain; Region: SelR; pfam01641
1288394012117	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1288394012118	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1288394012119	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1288394012120	active site
1288394012121	catalytic site [active]
1288394012122	glycogen branching enzyme; Provisional; Region: PRK05402
1288394012123	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1288394012124	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1288394012125	active site
1288394012126	catalytic site [active]
1288394012127	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1288394012128	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
1288394012129	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
1288394012130	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
1288394012131	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1288394012132	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1288394012133	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
1288394012134	active site
1288394012135	phosphate binding residues; other site
1288394012136	catalytic residues [active]
1288394012137	quinolinate synthetase; Provisional; Region: PRK09375
1288394012138	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1288394012139	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394012140	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394012141	dimer interface [polypeptide binding]; other site
1288394012142	putative CheW interface [polypeptide binding]; other site
1288394012143	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1288394012144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394012145	binding surface
1288394012146	TPR motif; other site
1288394012147	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
1288394012148	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394012149	ligand binding site [chemical binding]; other site
1288394012150	translocation protein TolB; Provisional; Region: tolB; PRK04792
1288394012151	TolB amino-terminal domain; Region: TolB_N; pfam04052
1288394012152	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1288394012153	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1288394012154	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1288394012155	TolA protein; Region: tolA_full; TIGR02794
1288394012156	TolA C-terminal; Region: TolA; pfam06519
1288394012157	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1288394012158	TolR protein; Region: tolR; TIGR02801
1288394012159	TolQ protein; Region: tolQ; TIGR02796
1288394012160	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1288394012161	active site
1288394012162	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
1288394012163	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
1288394012164	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1288394012165	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1288394012166	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1288394012167	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1288394012168	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1288394012169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394012170	Walker A motif; other site
1288394012171	ATP binding site [chemical binding]; other site
1288394012172	Walker B motif; other site
1288394012173	arginine finger; other site
1288394012174	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1288394012175	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1288394012176	RuvA N terminal domain; Region: RuvA_N; pfam01330
1288394012177	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1288394012178	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394012179	dimerization interface [polypeptide binding]; other site
1288394012180	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394012181	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394012182	dimer interface [polypeptide binding]; other site
1288394012183	putative CheW interface [polypeptide binding]; other site
1288394012184	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1288394012185	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1288394012186	dimer interface [polypeptide binding]; other site
1288394012187	motif 1; other site
1288394012188	active site
1288394012189	motif 2; other site
1288394012190	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1288394012191	putative deacylase active site [active]
1288394012192	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1288394012193	active site
1288394012194	motif 3; other site
1288394012195	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1288394012196	anticodon binding site; other site
1288394012197	3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939
1288394012198	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1288394012199	putative NAD(P) binding site [chemical binding]; other site
1288394012200	homotetramer interface [polypeptide binding]; other site
1288394012201	active site
1288394012202	homodimer interface [polypeptide binding]; other site
1288394012203	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
1288394012204	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1288394012205	enoyl-CoA hydratase; Provisional; Region: PRK06688
1288394012206	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1288394012207	substrate binding site [chemical binding]; other site
1288394012208	oxyanion hole (OAH) forming residues; other site
1288394012209	trimer interface [polypeptide binding]; other site
1288394012210	Protein of unknown function (DUF2753); Region: DUF2753; pfam10952
1288394012211	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1288394012212	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1288394012213	trimer interface [polypeptide binding]; other site
1288394012214	active site
1288394012215	substrate binding site [chemical binding]; other site
1288394012216	CoA binding site [chemical binding]; other site
1288394012217	Putative ParB-like nuclease; Region: ParBc_2; cl17538
1288394012218	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
1288394012219	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1288394012220	peptide binding site [polypeptide binding]; other site
1288394012221	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
1288394012222	hypothetical protein; Validated; Region: PRK05090
1288394012223	YGGT family; Region: YGGT; pfam02325
1288394012224	YGGT family; Region: YGGT; pfam02325
1288394012225	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1288394012226	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1288394012227	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
1288394012228	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1288394012229	catalytic residue [active]
1288394012230	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1288394012231	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1288394012232	Walker A motif; other site
1288394012233	ATP binding site [chemical binding]; other site
1288394012234	Walker B motif; other site
1288394012235	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
1288394012236	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1288394012237	Walker A motif; other site
1288394012238	ATP binding site [chemical binding]; other site
1288394012239	Walker B motif; other site
1288394012240	hypothetical protein; Validated; Region: PRK02101
1288394012241	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1288394012242	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1288394012243	ATP binding site [chemical binding]; other site
1288394012244	Mg++ binding site [ion binding]; other site
1288394012245	motif III; other site
1288394012246	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394012247	nucleotide binding region [chemical binding]; other site
1288394012248	ATP-binding site [chemical binding]; other site
1288394012249	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1288394012250	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394012251	S-adenosylmethionine binding site [chemical binding]; other site
1288394012252	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1288394012253	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
1288394012254	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
1288394012255	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1288394012256	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1288394012257	metal binding site 2 [ion binding]; metal-binding site
1288394012258	putative DNA binding helix; other site
1288394012259	metal binding site 1 [ion binding]; metal-binding site
1288394012260	dimer interface [polypeptide binding]; other site
1288394012261	structural Zn2+ binding site [ion binding]; other site
1288394012262	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1288394012263	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1288394012264	FMN binding site [chemical binding]; other site
1288394012265	active site
1288394012266	catalytic residues [active]
1288394012267	substrate binding site [chemical binding]; other site
1288394012268	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1288394012269	IHF dimer interface [polypeptide binding]; other site
1288394012270	IHF - DNA interface [nucleotide binding]; other site
1288394012271	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; cl11478
1288394012272	PilZ domain; Region: PilZ; pfam07238
1288394012273	DNA repair protein RadA; Provisional; Region: PRK11823
1288394012274	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1288394012275	Walker A motif/ATP binding site; other site
1288394012276	ATP binding site [chemical binding]; other site
1288394012277	Walker B motif; other site
1288394012278	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1288394012279	PilZ domain; Region: PilZ; pfam07238
1288394012280	PilZ domain; Region: PilZ; pfam07238
1288394012281	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1288394012282	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1288394012283	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1288394012284	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394012285	motif II; other site
1288394012286	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
1288394012287	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1288394012288	GAF domain; Region: GAF; pfam01590
1288394012289	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394012290	PAS domain; Region: PAS_9; pfam13426
1288394012291	putative active site [active]
1288394012292	heme pocket [chemical binding]; other site
1288394012293	PAS domain S-box; Region: sensory_box; TIGR00229
1288394012294	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394012295	putative active site [active]
1288394012296	heme pocket [chemical binding]; other site
1288394012297	PAS fold; Region: PAS_4; pfam08448
1288394012298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394012299	putative active site [active]
1288394012300	heme pocket [chemical binding]; other site
1288394012301	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394012302	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394012303	metal binding site [ion binding]; metal-binding site
1288394012304	active site
1288394012305	I-site; other site
1288394012306	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1288394012307	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1288394012308	phosphopentomutase; Provisional; Region: PRK05362
1288394012309	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1288394012310	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1288394012311	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1288394012312	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1288394012313	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1288394012314	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1288394012315	intersubunit interface [polypeptide binding]; other site
1288394012316	active site
1288394012317	catalytic residue [active]
1288394012318	XapX domain; Region: XapX; TIGR03510
1288394012319	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1288394012320	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1288394012321	Nucleoside recognition; Region: Gate; pfam07670
1288394012322	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1288394012323	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1288394012324	active site
1288394012325	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1288394012326	TRAM domain; Region: TRAM; pfam01938
1288394012327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394012328	S-adenosylmethionine binding site [chemical binding]; other site
1288394012329	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1288394012330	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1288394012331	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
1288394012332	dimer interface [polypeptide binding]; other site
1288394012333	active site
1288394012334	catalytic residues [active]
1288394012335	Int/Topo IB signature motif; other site
1288394012336	Predicted transcriptional regulator [Transcription]; Region: COG2932
1288394012337	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1288394012338	Catalytic site [active]
1288394012339	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
1288394012340	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394012341	non-specific DNA binding site [nucleotide binding]; other site
1288394012342	salt bridge; other site
1288394012343	sequence-specific DNA binding site [nucleotide binding]; other site
1288394012344	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1288394012345	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
1288394012346	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1288394012347	salt bridge; other site
1288394012348	non-specific DNA binding site [nucleotide binding]; other site
1288394012349	sequence-specific DNA binding site [nucleotide binding]; other site
1288394012350	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
1288394012351	portal vertex protein; Provisional; Region: Q; PHA02536
1288394012352	Phage portal protein; Region: Phage_portal; pfam04860
1288394012353	terminase ATPase subunit; Provisional; Region: P; PHA02535
1288394012354	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
1288394012355	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
1288394012356	capsid-scaffolding protein; Provisional; Region: O; PHA02529
1288394012357	capsid protein; Provisional; Region: N; PHA02538
1288394012358	terminase endonuclease subunit; Provisional; Region: M; PHA02537
1288394012359	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
1288394012360	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
1288394012361	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
1288394012362	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
1288394012363	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
1288394012364	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1288394012365	Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938
1288394012366	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
1288394012367	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394012368	catalytic residue [active]
1288394012369	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
1288394012370	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
1288394012371	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
1288394012372	Baseplate J-like protein; Region: Baseplate_J; cl01294
1288394012373	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
1288394012374	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1288394012375	active site
1288394012376	oxyanion hole [active]
1288394012377	catalytic triad [active]
1288394012378	RDD family; Region: RDD; pfam06271
1288394012379	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
1288394012380	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1288394012381	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1288394012382	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1288394012383	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1288394012384	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1288394012385	interface (dimer of trimers) [polypeptide binding]; other site
1288394012386	Substrate-binding/catalytic site; other site
1288394012387	Zn-binding sites [ion binding]; other site
1288394012388	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
1288394012389	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1288394012390	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1288394012391	HIGH motif; other site
1288394012392	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1288394012393	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1288394012394	active site
1288394012395	KMSKS motif; other site
1288394012396	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1288394012397	tRNA binding surface [nucleotide binding]; other site
1288394012398	anticodon binding site; other site
1288394012399	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1288394012400	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1288394012401	Domain of unknown function DUF21; Region: DUF21; pfam01595
1288394012402	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1288394012403	Transporter associated domain; Region: CorC_HlyC; smart01091
1288394012404	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1288394012405	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1288394012406	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1288394012407	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1288394012408	carbon storage regulator; Provisional; Region: PRK01712
1288394012409	aspartate kinase; Reviewed; Region: PRK06635
1288394012410	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1288394012411	putative nucleotide binding site [chemical binding]; other site
1288394012412	putative catalytic residues [active]
1288394012413	putative Mg ion binding site [ion binding]; other site
1288394012414	putative aspartate binding site [chemical binding]; other site
1288394012415	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1288394012416	putative allosteric regulatory site; other site
1288394012417	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1288394012418	putative allosteric regulatory residue; other site
1288394012419	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1288394012420	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1288394012421	motif 1; other site
1288394012422	active site
1288394012423	motif 2; other site
1288394012424	motif 3; other site
1288394012425	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1288394012426	DHHA1 domain; Region: DHHA1; pfam02272
1288394012427	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1288394012428	recombinase A; Provisional; Region: recA; PRK09354
1288394012429	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1288394012430	hexamer interface [polypeptide binding]; other site
1288394012431	Walker A motif; other site
1288394012432	ATP binding site [chemical binding]; other site
1288394012433	Walker B motif; other site
1288394012434	Competence-damaged protein; Region: CinA; cl00666
1288394012435	Patatin-like phospholipase; Region: Patatin; pfam01734
1288394012436	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
1288394012437	integrase; Provisional; Region: PRK09692
1288394012438	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1288394012439	active site
1288394012440	DNA binding site [nucleotide binding]
1288394012441	Int/Topo IB signature motif; other site
1288394012442	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1288394012443	MutS domain I; Region: MutS_I; pfam01624
1288394012444	MutS domain II; Region: MutS_II; pfam05188
1288394012445	MutS domain III; Region: MutS_III; pfam05192
1288394012446	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1288394012447	Walker A/P-loop; other site
1288394012448	ATP binding site [chemical binding]; other site
1288394012449	Q-loop/lid; other site
1288394012450	ABC transporter signature motif; other site
1288394012451	Walker B; other site
1288394012452	D-loop; other site
1288394012453	H-loop/switch region; other site
1288394012454	BCCT family transporter; Region: BCCT; pfam02028
1288394012455	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1288394012456	MarR family; Region: MarR; pfam01047
1288394012457	MarR family; Region: MarR_2; cl17246
1288394012458	Protein of unknown function (DUF416); Region: DUF416; pfam04222
1288394012459	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1288394012460	bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469
1288394012461	NAD binding site [chemical binding]; other site
1288394012462	ligand binding site [chemical binding]; other site
1288394012463	catalytic site [active]
1288394012464	putative peptidase; Provisional; Region: PRK11649
1288394012465	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
1288394012466	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394012467	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394012468	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1288394012469	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1288394012470	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
1288394012471	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
1288394012472	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
1288394012473	metal binding site [ion binding]; metal-binding site
1288394012474	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1288394012475	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1288394012476	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1288394012477	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394012478	ABC-ATPase subunit  interface; other site
1288394012479	dimer interface [polypeptide binding]; other site
1288394012480	putative PBP binding regions; other site
1288394012481	potential frameshift: common BLAST hit: gi|117620291|ref|YP_858179.1| LysR family transcriptional regulator
1288394012482	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394012483	EamA-like transporter family; Region: EamA; pfam00892
1288394012484	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1288394012485	putative uracil binding site [chemical binding]; other site
1288394012486	putative active site [active]
1288394012487	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1288394012488	EamA-like transporter family; Region: EamA; pfam00892
1288394012489	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394012490	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394012491	substrate binding pocket [chemical binding]; other site
1288394012492	membrane-bound complex binding site; other site
1288394012493	hinge residues; other site
1288394012494	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1288394012495	GIY-YIG motif/motif A; other site
1288394012496	putative active site [active]
1288394012497	putative metal binding site [ion binding]; other site
1288394012498	phage shock protein G; Reviewed; Region: pspG; PRK09459
1288394012499	PspC domain; Region: PspC; cl00864
1288394012500	phage shock protein A; Region: phageshock_pspA; TIGR02977
1288394012501	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1288394012502	putative acyl-acceptor binding pocket; other site
1288394012503	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1288394012504	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1288394012505	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1288394012506	DsbD alpha interface [polypeptide binding]; other site
1288394012507	catalytic residues [active]
1288394012508	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1288394012509	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
1288394012510	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1288394012511	catalytic residues [active]
1288394012512	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1288394012513	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
1288394012514	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1288394012515	catalytic residues [active]
1288394012516	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1288394012517	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1288394012518	HSP70 interaction site [polypeptide binding]; other site
1288394012519	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1288394012520	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1288394012521	CAP-like domain; other site
1288394012522	active site
1288394012523	primary dimer interface [polypeptide binding]; other site
1288394012524	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1288394012525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394012526	ATP binding site [chemical binding]; other site
1288394012527	Mg2+ binding site [ion binding]; other site
1288394012528	G-X-G motif; other site
1288394012529	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1288394012530	anchoring element; other site
1288394012531	dimer interface [polypeptide binding]; other site
1288394012532	ATP binding site [chemical binding]; other site
1288394012533	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1288394012534	active site
1288394012535	metal binding site [ion binding]; metal-binding site
1288394012536	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1288394012537	Fusaric acid resistance protein family; Region: FUSC; pfam04632
1288394012538	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1288394012539	HlyD family secretion protein; Region: HlyD; pfam00529
1288394012540	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1288394012541	HlyD family secretion protein; Region: HlyD_3; pfam13437
1288394012542	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
1288394012543	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1288394012544	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1288394012545	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1288394012546	nudix motif; other site
1288394012547	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1288394012548	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1288394012549	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1288394012550	active site
1288394012551	metal binding site [ion binding]; metal-binding site
1288394012552	hexamer interface [polypeptide binding]; other site
1288394012553	Protein of unknown function (DUF1249); Region: DUF1249; cl01223
1288394012554	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1288394012555	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1288394012556	dimer interface [polypeptide binding]; other site
1288394012557	ADP-ribose binding site [chemical binding]; other site
1288394012558	active site
1288394012559	nudix motif; other site
1288394012560	metal binding site [ion binding]; metal-binding site
1288394012561	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
1288394012562	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
1288394012563	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
1288394012564	putative ribose interaction site [chemical binding]; other site
1288394012565	putative ADP binding site [chemical binding]; other site
1288394012566	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1288394012567	active site
1288394012568	nucleotide binding site [chemical binding]; other site
1288394012569	HIGH motif; other site
1288394012570	KMSKS motif; other site
1288394012571	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1288394012572	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1288394012573	putative acyl-acceptor binding pocket; other site
1288394012574	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1288394012575	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
1288394012576	putative metal binding residues [ion binding]; other site
1288394012577	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1288394012578	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1288394012579	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1288394012580	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1288394012581	putative deacylase active site [active]
1288394012582	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1288394012583	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1288394012584	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1288394012585	active site residue [active]
1288394012586	OsmC-like protein; Region: OsmC; cl00767
1288394012587	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1288394012588	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394012589	DNA-binding site [nucleotide binding]; DNA binding site
1288394012590	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1288394012591	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394012592	homodimer interface [polypeptide binding]; other site
1288394012593	catalytic residue [active]
1288394012594	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394012595	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394012596	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1288394012597	putative dimerization interface [polypeptide binding]; other site
1288394012598	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1288394012599	LrgB-like family; Region: LrgB; pfam04172
1288394012600	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1288394012601	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
1288394012602	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1288394012603	active site
1288394012604	NTP binding site [chemical binding]; other site
1288394012605	metal binding triad [ion binding]; metal-binding site
1288394012606	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1288394012607	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1288394012608	Zn2+ binding site [ion binding]; other site
1288394012609	Mg2+ binding site [ion binding]; other site
1288394012610	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
1288394012611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394012612	Walker A motif; other site
1288394012613	ATP binding site [chemical binding]; other site
1288394012614	Walker B motif; other site
1288394012615	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1288394012616	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1288394012617	adenine DNA glycosylase; Provisional; Region: PRK10880
1288394012618	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1288394012619	minor groove reading motif; other site
1288394012620	helix-hairpin-helix signature motif; other site
1288394012621	substrate binding pocket [chemical binding]; other site
1288394012622	active site
1288394012623	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1288394012624	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1288394012625	DNA binding and oxoG recognition site [nucleotide binding]
1288394012626	oxidative damage protection protein; Provisional; Region: PRK05408
1288394012627	murein transglycosylase C; Provisional; Region: mltC; PRK11671
1288394012628	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
1288394012629	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1288394012630	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1288394012631	catalytic residue [active]
1288394012632	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
1288394012633	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
1288394012634	active site
1288394012635	catalytic triad [active]
1288394012636	oxyanion hole [active]
1288394012637	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394012638	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394012639	substrate binding pocket [chemical binding]; other site
1288394012640	membrane-bound complex binding site; other site
1288394012641	hinge residues; other site
1288394012642	outer membrane protein A; Reviewed; Region: PRK10808
1288394012643	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
1288394012644	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394012645	ligand binding site [chemical binding]; other site
1288394012646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
1288394012647	Protein of unknown function (DUF330); Region: DUF330; pfam03886
1288394012648	paraquat-inducible protein B; Provisional; Region: PRK10807
1288394012649	mce related protein; Region: MCE; pfam02470
1288394012650	mce related protein; Region: MCE; pfam02470
1288394012651	mce related protein; Region: MCE; pfam02470
1288394012652	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
1288394012653	Paraquat-inducible protein A; Region: PqiA; pfam04403
1288394012654	Paraquat-inducible protein A; Region: PqiA; pfam04403
1288394012655	bacterial Hfq-like; Region: Hfq; cd01716
1288394012656	hexamer interface [polypeptide binding]; other site
1288394012657	Sm1 motif; other site
1288394012658	RNA binding site [nucleotide binding]; other site
1288394012659	Sm2 motif; other site
1288394012660	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1288394012661	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394012662	motif II; other site
1288394012663	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
1288394012664	GAF domain; Region: GAF; cl17456
1288394012665	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394012666	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394012667	metal binding site [ion binding]; metal-binding site
1288394012668	active site
1288394012669	I-site; other site
1288394012670	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1288394012671	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1288394012672	dimer interface [polypeptide binding]; other site
1288394012673	active site
1288394012674	catalytic residue [active]
1288394012675	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
1288394012676	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
1288394012677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394012678	S-adenosylmethionine binding site [chemical binding]; other site
1288394012679	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1288394012680	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1288394012681	ligand binding site; other site
1288394012682	oligomer interface; other site
1288394012683	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1288394012684	dimer interface [polypeptide binding]; other site
1288394012685	N-terminal domain interface [polypeptide binding]; other site
1288394012686	sulfate 1 binding site; other site
1288394012687	glycogen synthase; Provisional; Region: glgA; PRK00654
1288394012688	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1288394012689	ADP-binding pocket [chemical binding]; other site
1288394012690	homodimer interface [polypeptide binding]; other site
1288394012691	Late competence development protein ComFB; Region: ComFB; pfam10719
1288394012692	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1288394012693	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394012694	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394012695	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
1288394012696	putative substrate binding pocket [chemical binding]; other site
1288394012697	dimerization interface [polypeptide binding]; other site
1288394012698	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1288394012699	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1288394012700	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1288394012701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394012702	Walker A/P-loop; other site
1288394012703	ATP binding site [chemical binding]; other site
1288394012704	Q-loop/lid; other site
1288394012705	ABC transporter signature motif; other site
1288394012706	Walker B; other site
1288394012707	D-loop; other site
1288394012708	H-loop/switch region; other site
1288394012709	TOBE domain; Region: TOBE_2; pfam08402
1288394012710	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1288394012711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394012712	dimer interface [polypeptide binding]; other site
1288394012713	conserved gate region; other site
1288394012714	putative PBP binding loops; other site
1288394012715	ABC-ATPase subunit interface; other site
1288394012716	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
1288394012717	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
1288394012718	tetrameric interface [polypeptide binding]; other site
1288394012719	NAD binding site [chemical binding]; other site
1288394012720	catalytic residues [active]
1288394012721	substrate binding site [chemical binding]; other site
1288394012722	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
1288394012723	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1288394012724	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1288394012725	AsnC family; Region: AsnC_trans_reg; pfam01037
1288394012726	maltose O-acetyltransferase; Provisional; Region: PRK10092
1288394012727	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1288394012728	active site
1288394012729	substrate binding site [chemical binding]; other site
1288394012730	trimer interface [polypeptide binding]; other site
1288394012731	CoA binding site [chemical binding]; other site
1288394012732	trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933
1288394012733	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1288394012734	Ca binding site [ion binding]; other site
1288394012735	active site
1288394012736	catalytic site [active]
1288394012737	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1288394012738	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
1288394012739	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1288394012740	active site turn [active]
1288394012741	phosphorylation site [posttranslational modification]
1288394012742	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1288394012743	trehalose repressor; Provisional; Region: treR; PRK09492
1288394012744	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394012745	DNA binding site [nucleotide binding]
1288394012746	domain linker motif; other site
1288394012747	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
1288394012748	dimerization interface [polypeptide binding]; other site
1288394012749	ligand binding site [chemical binding]; other site
1288394012750	Predicted permeases [General function prediction only]; Region: COG0679
1288394012751	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1288394012752	metal-binding site [ion binding]
1288394012753	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
1288394012754	active site
1288394012755	homodimer interface [polypeptide binding]; other site
1288394012756	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
1288394012757	Superinfection exclusion protein B; Region: SieB; pfam14163
1288394012758	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1288394012759	active site
1288394012760	dimer interfaces [polypeptide binding]; other site
1288394012761	catalytic residues [active]
1288394012762	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
1288394012763	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1288394012764	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1288394012765	heme binding site [chemical binding]; other site
1288394012766	ferroxidase pore; other site
1288394012767	ferroxidase diiron center [ion binding]; other site
1288394012768	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
1288394012769	Transcriptional activator HlyU; Region: HlyU; pfam10115
1288394012770	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
1288394012771	Helicase; Region: Helicase_RecD; pfam05127
1288394012772	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394012773	Coenzyme A binding pocket [chemical binding]; other site
1288394012774	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
1288394012775	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1288394012776	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1288394012777	NADP binding site [chemical binding]; other site
1288394012778	homodimer interface [polypeptide binding]; other site
1288394012779	active site
1288394012780	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1288394012781	Response regulator receiver domain; Region: Response_reg; pfam00072
1288394012782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394012783	active site
1288394012784	phosphorylation site [posttranslational modification]
1288394012785	intermolecular recognition site; other site
1288394012786	dimerization interface [polypeptide binding]; other site
1288394012787	Nucleoside recognition; Region: Gate; pfam07670
1288394012788	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
1288394012789	Ion channel; Region: Ion_trans_2; pfam07885
1288394012790	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1288394012791	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1288394012792	homooctamer interface [polypeptide binding]; other site
1288394012793	active site
1288394012794	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1288394012795	catalytic center binding site [active]
1288394012796	ATP binding site [chemical binding]; other site
1288394012797	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1288394012798	putative deacylase active site [active]
1288394012799	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394012800	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1288394012801	putative substrate translocation pore; other site
1288394012802	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1288394012803	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1288394012804	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1288394012805	potential frameshift: common BLAST hit: gi|117621252|ref|YP_858291.1| FAD binding domain-containing protein
1288394012806	LysE type translocator; Region: LysE; cl00565
1288394012807	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1288394012808	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394012809	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394012810	dimerization interface [polypeptide binding]; other site
1288394012811	potential frameshift: common BLAST hit: gi|117618668|ref|YP_858294.1| EAL domain-containing protein
1288394012812	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1288394012813	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1288394012814	substrate binding site [chemical binding]; other site
1288394012815	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1288394012816	substrate binding site [chemical binding]; other site
1288394012817	ligand binding site [chemical binding]; other site
1288394012818	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1288394012819	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
1288394012820	active site
1288394012821	nucleophile elbow; other site
1288394012822	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1288394012823	Surface antigen; Region: Bac_surface_Ag; pfam01103
1288394012824	Cache domain; Region: Cache_1; pfam02743
1288394012825	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394012826	dimerization interface [polypeptide binding]; other site
1288394012827	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394012828	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394012829	dimer interface [polypeptide binding]; other site
1288394012830	putative CheW interface [polypeptide binding]; other site
1288394012831	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1288394012832	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394012833	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394012834	dimer interface [polypeptide binding]; other site
1288394012835	putative CheW interface [polypeptide binding]; other site
1288394012836	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1288394012837	GAF domain; Region: GAF; pfam01590
1288394012838	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394012839	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394012840	metal binding site [ion binding]; metal-binding site
1288394012841	active site
1288394012842	I-site; other site
1288394012843	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1288394012844	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1288394012845	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394012846	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1288394012847	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
1288394012848	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394012849	E3 interaction surface; other site
1288394012850	lipoyl attachment site [posttranslational modification]; other site
1288394012851	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394012852	E3 interaction surface; other site
1288394012853	lipoyl attachment site [posttranslational modification]; other site
1288394012854	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1288394012855	E3 interaction surface; other site
1288394012856	lipoyl attachment site [posttranslational modification]; other site
1288394012857	e3 binding domain; Region: E3_binding; pfam02817
1288394012858	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1288394012859	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1288394012860	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1288394012861	dimer interface [polypeptide binding]; other site
1288394012862	TPP-binding site [chemical binding]; other site
1288394012863	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1288394012864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394012865	DNA-binding site [nucleotide binding]; DNA binding site
1288394012866	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1288394012867	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1288394012868	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1288394012869	substrate binding site [chemical binding]; other site
1288394012870	amidase catalytic site [active]
1288394012871	Zn binding residues [ion binding]; other site
1288394012872	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1288394012873	catalytic motif [active]
1288394012874	Catalytic residue [active]
1288394012875	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
1288394012876	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1288394012877	dimerization interface [polypeptide binding]; other site
1288394012878	active site
1288394012879	putative major pilin subunit; Provisional; Region: PRK10574
1288394012880	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1288394012881	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1288394012882	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1288394012883	Walker A motif; other site
1288394012884	ATP binding site [chemical binding]; other site
1288394012885	Walker B motif; other site
1288394012886	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1288394012887	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394012888	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1288394012889	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1288394012890	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1288394012891	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1288394012892	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1288394012893	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1288394012894	CoA-binding site [chemical binding]; other site
1288394012895	ATP-binding [chemical binding]; other site
1288394012896	hypothetical protein; Provisional; Region: PRK05287
1288394012897	Domain of unknown function (DUF329); Region: DUF329; cl01144
1288394012898	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1288394012899	active site
1288394012900	8-oxo-dGMP binding site [chemical binding]; other site
1288394012901	nudix motif; other site
1288394012902	metal binding site [ion binding]; metal-binding site
1288394012903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1288394012904	TPR motif; other site
1288394012905	binding surface
1288394012906	TPR repeat; Region: TPR_11; pfam13414
1288394012907	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1288394012908	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1288394012909	SEC-C motif; Region: SEC-C; pfam02810
1288394012910	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1288394012911	Peptidase family M23; Region: Peptidase_M23; pfam01551
1288394012912	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1288394012913	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1288394012914	cell division protein FtsZ; Validated; Region: PRK09330
1288394012915	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1288394012916	nucleotide binding site [chemical binding]; other site
1288394012917	SulA interaction site; other site
1288394012918	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
1288394012919	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1288394012920	nucleotide binding site [chemical binding]; other site
1288394012921	Cell division protein FtsA; Region: FtsA; pfam14450
1288394012922	cell division protein FtsQ; Provisional; Region: PRK10775
1288394012923	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1288394012924	Cell division protein FtsQ; Region: FtsQ; pfam03799
1288394012925	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1288394012926	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1288394012927	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1288394012928	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1288394012929	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1288394012930	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1288394012931	active site
1288394012932	homodimer interface [polypeptide binding]; other site
1288394012933	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1288394012934	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
1288394012935	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1288394012936	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1288394012937	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1288394012938	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1288394012939	Mg++ binding site [ion binding]; other site
1288394012940	putative catalytic motif [active]
1288394012941	putative substrate binding site [chemical binding]; other site
1288394012942	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
1288394012943	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1288394012944	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1288394012945	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1288394012946	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1288394012947	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1288394012948	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1288394012949	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1288394012950	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
1288394012951	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1288394012952	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1288394012953	Cell division protein FtsL; Region: FtsL; pfam04999
1288394012954	MraW methylase family; Region: Methyltransf_5; pfam01795
1288394012955	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1288394012956	cell division protein MraZ; Reviewed; Region: PRK00326
1288394012957	MraZ protein; Region: MraZ; pfam02381
1288394012958	MraZ protein; Region: MraZ; pfam02381
1288394012959	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
1288394012960	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1288394012961	putative SAM binding site [chemical binding]; other site
1288394012962	putative homodimer interface [polypeptide binding]; other site
1288394012963	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
1288394012964	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1288394012965	putative ligand binding site [chemical binding]; other site
1288394012966	hypothetical protein; Reviewed; Region: PRK12497
1288394012967	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1288394012968	dimer interface [polypeptide binding]; other site
1288394012969	active site
1288394012970	BON domain; Region: BON; pfam04972
1288394012971	BON domain; Region: BON; pfam04972
1288394012972	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
1288394012973	stringent starvation protein A; Provisional; Region: sspA; PRK09481
1288394012974	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
1288394012975	C-terminal domain interface [polypeptide binding]; other site
1288394012976	putative GSH binding site (G-site) [chemical binding]; other site
1288394012977	dimer interface [polypeptide binding]; other site
1288394012978	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
1288394012979	dimer interface [polypeptide binding]; other site
1288394012980	N-terminal domain interface [polypeptide binding]; other site
1288394012981	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1288394012982	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1288394012983	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1288394012984	Qi binding site; other site
1288394012985	intrachain domain interface; other site
1288394012986	interchain domain interface [polypeptide binding]; other site
1288394012987	heme bH binding site [chemical binding]; other site
1288394012988	heme bL binding site [chemical binding]; other site
1288394012989	Qo binding site; other site
1288394012990	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
1288394012991	interchain domain interface [polypeptide binding]; other site
1288394012992	intrachain domain interface; other site
1288394012993	Qi binding site; other site
1288394012994	Qo binding site; other site
1288394012995	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
1288394012996	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1288394012997	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1288394012998	[2Fe-2S] cluster binding site [ion binding]; other site
1288394012999	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1288394013000	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1288394013001	23S rRNA interface [nucleotide binding]; other site
1288394013002	L3 interface [polypeptide binding]; other site
1288394013003	Predicted ATPase [General function prediction only]; Region: COG1485
1288394013004	Protein of unknown function (DUF1043); Region: DUF1043; pfam06295
1288394013005	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1288394013006	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1288394013007	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1288394013008	protein binding site [polypeptide binding]; other site
1288394013009	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1288394013010	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1288394013011	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1288394013012	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1288394013013	protein binding site [polypeptide binding]; other site
1288394013014	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1288394013015	conserved hypothetical protein EF_0830/AHA_3911; Region: EF_0830; TIGR03577
1288394013016	conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578
1288394013017	Domain of unknown function (DUF4311); Region: DUF4311; cl11919
1288394013018	conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579
1288394013019	probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583
1288394013020	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1288394013021	active site
1288394013022	uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437
1288394013023	catalytic residue [active]
1288394013024	Protein of unknown function (DUF1341); Region: DUF1341; pfam07071
1288394013025	HTH domain; Region: HTH_11; pfam08279
1288394013026	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1288394013027	Mga helix-turn-helix domain; Region: Mga; pfam05043
1288394013028	PRD domain; Region: PRD; pfam00874
1288394013029	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1288394013030	active site
1288394013031	P-loop; other site
1288394013032	phosphorylation site [posttranslational modification]
1288394013033	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394013034	active site
1288394013035	phosphorylation site [posttranslational modification]
1288394013036	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1288394013037	dimerization domain swap beta strand [polypeptide binding]; other site
1288394013038	regulatory protein interface [polypeptide binding]; other site
1288394013039	active site
1288394013040	regulatory phosphorylation site [posttranslational modification]; other site
1288394013041	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1288394013042	AAA domain; Region: AAA_18; pfam13238
1288394013043	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1288394013044	active site
1288394013045	phosphorylation site [posttranslational modification]
1288394013046	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1288394013047	30S subunit binding site; other site
1288394013048	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1288394013049	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1288394013050	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1288394013051	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1288394013052	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1288394013053	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1288394013054	Walker A/P-loop; other site
1288394013055	ATP binding site [chemical binding]; other site
1288394013056	Q-loop/lid; other site
1288394013057	ABC transporter signature motif; other site
1288394013058	Walker B; other site
1288394013059	D-loop; other site
1288394013060	H-loop/switch region; other site
1288394013061	OstA-like protein; Region: OstA; cl00844
1288394013062	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1288394013063	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1288394013064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
1288394013065	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1288394013066	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394013067	active site
1288394013068	motif I; other site
1288394013069	motif II; other site
1288394013070	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1288394013071	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1288394013072	putative active site [active]
1288394013073	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1288394013074	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
1288394013075	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1288394013076	Walker A/P-loop; other site
1288394013077	ATP binding site [chemical binding]; other site
1288394013078	Q-loop/lid; other site
1288394013079	ABC transporter signature motif; other site
1288394013080	Walker B; other site
1288394013081	D-loop; other site
1288394013082	H-loop/switch region; other site
1288394013083	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1288394013084	conserved hypothetical integral membrane protein; Region: TIGR00056
1288394013085	mce related protein; Region: MCE; pfam02470
1288394013086	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
1288394013087	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1288394013088	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
1288394013089	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1288394013090	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1288394013091	hinge; other site
1288394013092	active site
1288394013093	peptidase PmbA; Provisional; Region: PRK11040
1288394013094	hypothetical protein; Provisional; Region: PRK05255
1288394013095	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1288394013096	Transglycosylase; Region: Transgly; cl17702
1288394013097	hypothetical protein; Provisional; Region: PRK05423
1288394013098	NnrS protein; Region: NnrS; pfam05940
1288394013099	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1288394013100	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394013101	non-specific DNA binding site [nucleotide binding]; other site
1288394013102	salt bridge; other site
1288394013103	sequence-specific DNA binding site [nucleotide binding]; other site
1288394013104	Cupin domain; Region: Cupin_2; pfam07883
1288394013105	Benzoate membrane transport protein; Region: BenE; pfam03594
1288394013106	benzoate transporter; Region: benE; TIGR00843
1288394013107	Protein of unknown function (DUF3103); Region: DUF3103; pfam11301
1288394013108	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1288394013109	FAD binding site [chemical binding]; other site
1288394013110	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1288394013111	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1288394013112	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1288394013113	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1288394013114	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394013115	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394013116	dimer interface [polypeptide binding]; other site
1288394013117	putative CheW interface [polypeptide binding]; other site
1288394013118	OmpW family; Region: OmpW; cl17427
1288394013119	potential frameshift: common BLAST hit: gi|117617470|ref|YP_858388.1| PAS/GGDEF domain-containing protein
1288394013120	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1288394013121	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1288394013122	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1288394013123	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1288394013124	DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100
1288394013125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394013126	DNA binding residues [nucleotide binding]
1288394013127	dimerization interface [polypeptide binding]; other site
1288394013128	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1288394013129	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1288394013130	dimer interface [polypeptide binding]; other site
1288394013131	ssDNA binding site [nucleotide binding]; other site
1288394013132	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1288394013133	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1288394013134	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394013135	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394013136	substrate binding pocket [chemical binding]; other site
1288394013137	membrane-bound complex binding site; other site
1288394013138	hinge residues; other site
1288394013139	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1288394013140	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1288394013141	YjbD family (DUF3811); Region: DUF3811; cl08125
1288394013142	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1288394013143	DNA-binding site [nucleotide binding]; DNA binding site
1288394013144	RNA-binding motif; other site
1288394013145	putative outer membrane receptor; Provisional; Region: PRK13513
1288394013146	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394013147	N-terminal plug; other site
1288394013148	ligand-binding site [chemical binding]; other site
1288394013149	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394013150	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394013151	substrate binding pocket [chemical binding]; other site
1288394013152	membrane-bound complex binding site; other site
1288394013153	hinge residues; other site
1288394013154	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394013155	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394013156	metal binding site [ion binding]; metal-binding site
1288394013157	active site
1288394013158	I-site; other site
1288394013159	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394013160	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394013161	dimerization interface [polypeptide binding]; other site
1288394013162	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394013163	dimer interface [polypeptide binding]; other site
1288394013164	phosphorylation site [posttranslational modification]
1288394013165	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394013166	ATP binding site [chemical binding]; other site
1288394013167	Mg2+ binding site [ion binding]; other site
1288394013168	G-X-G motif; other site
1288394013169	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1288394013170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394013171	active site
1288394013172	phosphorylation site [posttranslational modification]
1288394013173	intermolecular recognition site; other site
1288394013174	dimerization interface [polypeptide binding]; other site
1288394013175	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394013176	DNA binding site [nucleotide binding]
1288394013177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1288394013178	PAS fold; Region: PAS_3; pfam08447
1288394013179	putative active site [active]
1288394013180	heme pocket [chemical binding]; other site
1288394013181	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394013182	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394013183	metal binding site [ion binding]; metal-binding site
1288394013184	active site
1288394013185	I-site; other site
1288394013186	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394013187	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394013188	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1288394013189	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1288394013190	active site
1288394013191	metal binding site [ion binding]; metal-binding site
1288394013192	AAA domain; Region: AAA_21; pfam13304
1288394013193	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
1288394013194	AAA domain; Region: AAA_30; pfam13604
1288394013195	Family description; Region: UvrD_C_2; pfam13538
1288394013196	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1288394013197	Family description; Region: UvrD_C_2; pfam13538
1288394013198	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1288394013199	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
1288394013200	Predicted membrane protein [Function unknown]; Region: COG2259
1288394013201	Pirin-related protein [General function prediction only]; Region: COG1741
1288394013202	Pirin; Region: Pirin; pfam02678
1288394013203	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1288394013204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394013205	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
1288394013206	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394013207	dimerization interface [polypeptide binding]; other site
1288394013208	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1288394013209	non-specific DNA binding site [nucleotide binding]; other site
1288394013210	salt bridge; other site
1288394013211	sequence-specific DNA binding site [nucleotide binding]; other site
1288394013212	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1288394013213	transcriptional regulator protein; Region: phnR; TIGR03337
1288394013214	DNA-binding site [nucleotide binding]; DNA binding site
1288394013215	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1288394013216	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1288394013217	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1288394013218	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
1288394013219	Sulfatase; Region: Sulfatase; cl17466
1288394013220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394013221	dimer interface [polypeptide binding]; other site
1288394013222	conserved gate region; other site
1288394013223	ABC-ATPase subunit interface; other site
1288394013224	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1288394013225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394013226	dimer interface [polypeptide binding]; other site
1288394013227	conserved gate region; other site
1288394013228	putative PBP binding loops; other site
1288394013229	ABC-ATPase subunit interface; other site
1288394013230	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1288394013231	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394013232	Walker A/P-loop; other site
1288394013233	ATP binding site [chemical binding]; other site
1288394013234	Q-loop/lid; other site
1288394013235	ABC transporter signature motif; other site
1288394013236	Walker B; other site
1288394013237	D-loop; other site
1288394013238	H-loop/switch region; other site
1288394013239	TOBE domain; Region: TOBE_2; pfam08402
1288394013240	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1288394013241	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1288394013242	Cache domain; Region: Cache_1; pfam02743
1288394013243	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394013244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394013245	metal binding site [ion binding]; metal-binding site
1288394013246	active site
1288394013247	I-site; other site
1288394013248	Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980
1288394013249	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1288394013250	EamA-like transporter family; Region: EamA; pfam00892
1288394013251	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394013252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394013253	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1288394013254	putative acetyltransferase YhhY; Provisional; Region: PRK10140
1288394013255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1288394013256	Coenzyme A binding pocket [chemical binding]; other site
1288394013257	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1288394013258	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1288394013259	tetramer interface [polypeptide binding]; other site
1288394013260	heme binding pocket [chemical binding]; other site
1288394013261	NADPH binding site [chemical binding]; other site
1288394013262	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
1288394013263	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1288394013264	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394013265	substrate binding pocket [chemical binding]; other site
1288394013266	membrane-bound complex binding site; other site
1288394013267	hinge residues; other site
1288394013268	NUDIX domain; Region: NUDIX; pfam00293
1288394013269	nudix motif; other site
1288394013270	PAP2 superfamily; Region: PAP2; pfam01569
1288394013271	active site
1288394013272	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1288394013273	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1288394013274	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1288394013275	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1288394013276	classical (c) SDRs; Region: SDR_c; cd05233
1288394013277	NAD(P) binding site [chemical binding]; other site
1288394013278	active site
1288394013279	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
1288394013280	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
1288394013281	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1288394013282	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394013283	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1288394013284	dimerization interface [polypeptide binding]; other site
1288394013285	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
1288394013286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394013287	Walker A motif; other site
1288394013288	ATP binding site [chemical binding]; other site
1288394013289	Walker B motif; other site
1288394013290	arginine finger; other site
1288394013291	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1288394013292	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1288394013293	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1288394013294	dimer interface [polypeptide binding]; other site
1288394013295	active site
1288394013296	metal binding site [ion binding]; metal-binding site
1288394013297	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1288394013298	active pocket/dimerization site; other site
1288394013299	active site
1288394013300	phosphorylation site [posttranslational modification]
1288394013301	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1288394013302	dimerization domain swap beta strand [polypeptide binding]; other site
1288394013303	regulatory protein interface [polypeptide binding]; other site
1288394013304	active site
1288394013305	regulatory phosphorylation site [posttranslational modification]; other site
1288394013306	DAK2 domain; Region: Dak2; cl03685
1288394013307	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
1288394013308	Dak1 domain; Region: Dak1; pfam02733
1288394013309	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1288394013310	nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890
1288394013311	Cupin domain; Region: Cupin_2; cl17218
1288394013312	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1288394013313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394013314	active site
1288394013315	motif I; other site
1288394013316	motif II; other site
1288394013317	elongation factor Tu; Reviewed; Region: PRK00049
1288394013318	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1288394013319	G1 box; other site
1288394013320	GEF interaction site [polypeptide binding]; other site
1288394013321	GTP/Mg2+ binding site [chemical binding]; other site
1288394013322	Switch I region; other site
1288394013323	G2 box; other site
1288394013324	G3 box; other site
1288394013325	Switch II region; other site
1288394013326	G4 box; other site
1288394013327	G5 box; other site
1288394013328	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1288394013329	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1288394013330	Antibiotic Binding Site [chemical binding]; other site
1288394013331	elongation factor G; Reviewed; Region: PRK00007
1288394013332	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1288394013333	G1 box; other site
1288394013334	putative GEF interaction site [polypeptide binding]; other site
1288394013335	GTP/Mg2+ binding site [chemical binding]; other site
1288394013336	Switch I region; other site
1288394013337	G2 box; other site
1288394013338	G3 box; other site
1288394013339	Switch II region; other site
1288394013340	G4 box; other site
1288394013341	G5 box; other site
1288394013342	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1288394013343	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1288394013344	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1288394013345	30S ribosomal protein S7; Validated; Region: PRK05302
1288394013346	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1288394013347	S17 interaction site [polypeptide binding]; other site
1288394013348	S8 interaction site; other site
1288394013349	16S rRNA interaction site [nucleotide binding]; other site
1288394013350	streptomycin interaction site [chemical binding]; other site
1288394013351	23S rRNA interaction site [nucleotide binding]; other site
1288394013352	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1288394013353	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
1288394013354	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
1288394013355	sulfur relay protein TusD/DsrE; Region: sulf_tusD_dsrE; TIGR03012
1288394013356	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1288394013357	homotrimer interaction site [polypeptide binding]; other site
1288394013358	putative active site [active]
1288394013359	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1288394013360	YheO-like PAS domain; Region: PAS_6; pfam08348
1288394013361	HTH domain; Region: HTH_22; pfam13309
1288394013362	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
1288394013363	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1288394013364	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
1288394013365	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1288394013366	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1288394013367	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1288394013368	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1288394013369	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1288394013370	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1288394013371	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1288394013372	DNA binding site [nucleotide binding]
1288394013373	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1288394013374	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1288394013375	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1288394013376	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1288394013377	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1288394013378	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
1288394013379	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1288394013380	RPB3 interaction site [polypeptide binding]; other site
1288394013381	RPB1 interaction site [polypeptide binding]; other site
1288394013382	RPB11 interaction site [polypeptide binding]; other site
1288394013383	RPB10 interaction site [polypeptide binding]; other site
1288394013384	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1288394013385	core dimer interface [polypeptide binding]; other site
1288394013386	peripheral dimer interface [polypeptide binding]; other site
1288394013387	L10 interface [polypeptide binding]; other site
1288394013388	L11 interface [polypeptide binding]; other site
1288394013389	putative EF-Tu interaction site [polypeptide binding]; other site
1288394013390	putative EF-G interaction site [polypeptide binding]; other site
1288394013391	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1288394013392	23S rRNA interface [nucleotide binding]; other site
1288394013393	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1288394013394	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1288394013395	mRNA/rRNA interface [nucleotide binding]; other site
1288394013396	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1288394013397	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1288394013398	23S rRNA interface [nucleotide binding]; other site
1288394013399	L7/L12 interface [polypeptide binding]; other site
1288394013400	putative thiostrepton binding site; other site
1288394013401	L25 interface [polypeptide binding]; other site
1288394013402	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1288394013403	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1288394013404	putative homodimer interface [polypeptide binding]; other site
1288394013405	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1288394013406	heterodimer interface [polypeptide binding]; other site
1288394013407	homodimer interface [polypeptide binding]; other site
1288394013408	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
1288394013409	elongation factor Tu; Reviewed; Region: PRK00049
1288394013410	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1288394013411	G1 box; other site
1288394013412	GEF interaction site [polypeptide binding]; other site
1288394013413	GTP/Mg2+ binding site [chemical binding]; other site
1288394013414	Switch I region; other site
1288394013415	G2 box; other site
1288394013416	G3 box; other site
1288394013417	Switch II region; other site
1288394013418	G4 box; other site
1288394013419	G5 box; other site
1288394013420	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1288394013421	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1288394013422	Antibiotic Binding Site [chemical binding]; other site
1288394013423	pantothenate kinase; Provisional; Region: PRK05439
1288394013424	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1288394013425	ATP-binding site [chemical binding]; other site
1288394013426	CoA-binding site [chemical binding]; other site
1288394013427	Mg2+-binding site [ion binding]; other site
1288394013428	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394013429	putative DNA binding site [nucleotide binding]; other site
1288394013430	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1288394013431	putative Zn2+ binding site [ion binding]; other site
1288394013432	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1288394013433	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1288394013434	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
1288394013435	FAD binding domain; Region: FAD_binding_4; pfam01565
1288394013436	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1288394013437	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1288394013438	TrkA-N domain; Region: TrkA_N; pfam02254
1288394013439	TrkA-C domain; Region: TrkA_C; pfam02080
1288394013440	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1288394013441	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1288394013442	Cupin; Region: Cupin_6; pfam12852
1288394013443	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1288394013444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394013445	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1288394013446	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1288394013447	Protein of unknown function, DUF417; Region: DUF417; cl01162
1288394013448	DNA topoisomerase III; Provisional; Region: PRK07726
1288394013449	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1288394013450	active site
1288394013451	putative interdomain interaction site [polypeptide binding]; other site
1288394013452	putative metal-binding site [ion binding]; other site
1288394013453	putative nucleotide binding site [chemical binding]; other site
1288394013454	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1288394013455	domain I; other site
1288394013456	DNA binding groove [nucleotide binding]
1288394013457	phosphate binding site [ion binding]; other site
1288394013458	domain II; other site
1288394013459	domain III; other site
1288394013460	nucleotide binding site [chemical binding]; other site
1288394013461	catalytic site [active]
1288394013462	domain IV; other site
1288394013463	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
1288394013464	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
1288394013465	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
1288394013466	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
1288394013467	molybdopterin cofactor binding site [chemical binding]; other site
1288394013468	substrate binding site [chemical binding]; other site
1288394013469	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
1288394013470	molybdopterin cofactor binding site; other site
1288394013471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394013472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394013473	ATP binding site [chemical binding]; other site
1288394013474	Mg2+ binding site [ion binding]; other site
1288394013475	G-X-G motif; other site
1288394013476	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1288394013477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394013478	active site
1288394013479	phosphorylation site [posttranslational modification]
1288394013480	intermolecular recognition site; other site
1288394013481	dimerization interface [polypeptide binding]; other site
1288394013482	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394013483	DNA binding site [nucleotide binding]
1288394013484	Predicted membrane protein [Function unknown]; Region: COG3212
1288394013485	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
1288394013486	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1288394013487	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1288394013488	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1288394013489	Moco binding site; other site
1288394013490	metal coordination site [ion binding]; other site
1288394013491	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
1288394013492	response regulator GlrR; Provisional; Region: PRK15115
1288394013493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394013494	active site
1288394013495	phosphorylation site [posttranslational modification]
1288394013496	intermolecular recognition site; other site
1288394013497	dimerization interface [polypeptide binding]; other site
1288394013498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394013499	Walker A motif; other site
1288394013500	ATP binding site [chemical binding]; other site
1288394013501	Walker B motif; other site
1288394013502	arginine finger; other site
1288394013503	CHASE3 domain; Region: CHASE3; cl05000
1288394013504	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1288394013505	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394013506	dimer interface [polypeptide binding]; other site
1288394013507	phosphorylation site [posttranslational modification]
1288394013508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394013509	ATP binding site [chemical binding]; other site
1288394013510	Mg2+ binding site [ion binding]; other site
1288394013511	G-X-G motif; other site
1288394013512	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
1288394013513	catalytic center binding site [active]
1288394013514	ATP binding site [chemical binding]; other site
1288394013515	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394013516	dihydromonapterin reductase; Provisional; Region: PRK06483
1288394013517	NAD(P) binding site [chemical binding]; other site
1288394013518	active site
1288394013519	FOG: CBS domain [General function prediction only]; Region: COG0517
1288394013520	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
1288394013521	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; pfam10063
1288394013522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394013523	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394013524	substrate binding pocket [chemical binding]; other site
1288394013525	membrane-bound complex binding site; other site
1288394013526	hinge residues; other site
1288394013527	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
1288394013528	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1288394013529	putative DNA binding site [nucleotide binding]; other site
1288394013530	putative Zn2+ binding site [ion binding]; other site
1288394013531	AsnC family; Region: AsnC_trans_reg; pfam01037
1288394013532	asparagine synthetase AsnA; Provisional; Region: PRK05425
1288394013533	motif 1; other site
1288394013534	dimer interface [polypeptide binding]; other site
1288394013535	active site
1288394013536	motif 2; other site
1288394013537	motif 3; other site
1288394013538	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
1288394013539	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1288394013540	Clp amino terminal domain; Region: Clp_N; pfam02861
1288394013541	Clp amino terminal domain; Region: Clp_N; pfam02861
1288394013542	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394013543	Walker A motif; other site
1288394013544	ATP binding site [chemical binding]; other site
1288394013545	Walker B motif; other site
1288394013546	arginine finger; other site
1288394013547	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394013548	Walker A motif; other site
1288394013549	ATP binding site [chemical binding]; other site
1288394013550	Walker B motif; other site
1288394013551	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1288394013552	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1288394013553	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1288394013554	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
1288394013555	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1288394013556	RNA binding surface [nucleotide binding]; other site
1288394013557	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1288394013558	active site
1288394013559	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1288394013560	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1288394013561	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1288394013562	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1288394013563	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
1288394013564	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1288394013565	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
1288394013566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
1288394013567	YheO-like PAS domain; Region: PAS_6; pfam08348
1288394013568	HTH domain; Region: HTH_22; pfam13309
1288394013569	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394013570	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394013571	substrate binding pocket [chemical binding]; other site
1288394013572	membrane-bound complex binding site; other site
1288394013573	hinge residues; other site
1288394013574	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
1288394013575	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1288394013576	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1288394013577	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1288394013578	ligand binding site [chemical binding]; other site
1288394013579	homodimer interface [polypeptide binding]; other site
1288394013580	NAD(P) binding site [chemical binding]; other site
1288394013581	trimer interface B [polypeptide binding]; other site
1288394013582	trimer interface A [polypeptide binding]; other site
1288394013583	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1288394013584	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1288394013585	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1288394013586	dimer interface [polypeptide binding]; other site
1288394013587	active site
1288394013588	metal binding site [ion binding]; metal-binding site
1288394013589	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1288394013590	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1288394013591	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1288394013592	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1288394013593	Cache domain; Region: Cache_1; pfam02743
1288394013594	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394013595	dimerization interface [polypeptide binding]; other site
1288394013596	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394013597	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394013598	dimer interface [polypeptide binding]; other site
1288394013599	putative CheW interface [polypeptide binding]; other site
1288394013600	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
1288394013601	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
1288394013602	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
1288394013603	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1288394013604	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1288394013605	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
1288394013606	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
1288394013607	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
1288394013608	arginine repressor; Provisional; Region: PRK05066
1288394013609	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1288394013610	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1288394013611	Predicted membrane protein [Function unknown]; Region: COG1288
1288394013612	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1288394013613	ornithine carbamoyltransferase; Validated; Region: PRK02102
1288394013614	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1288394013615	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1288394013616	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
1288394013617	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1288394013618	putative substrate binding site [chemical binding]; other site
1288394013619	nucleotide binding site [chemical binding]; other site
1288394013620	nucleotide binding site [chemical binding]; other site
1288394013621	homodimer interface [polypeptide binding]; other site
1288394013622	arginine deiminase; Provisional; Region: PRK01388
1288394013623	ParA-like protein; Provisional; Region: PHA02518
1288394013624	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1288394013625	P-loop; other site
1288394013626	Magnesium ion binding site [ion binding]; other site
1288394013627	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394013628	dimerization interface [polypeptide binding]; other site
1288394013629	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394013630	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394013631	dimer interface [polypeptide binding]; other site
1288394013632	putative CheW interface [polypeptide binding]; other site
1288394013633	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1288394013634	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1288394013635	TM-ABC transporter signature motif; other site
1288394013636	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1288394013637	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
1288394013638	Walker A/P-loop; other site
1288394013639	ATP binding site [chemical binding]; other site
1288394013640	Q-loop/lid; other site
1288394013641	ABC transporter signature motif; other site
1288394013642	Walker B; other site
1288394013643	D-loop; other site
1288394013644	H-loop/switch region; other site
1288394013645	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1288394013646	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
1288394013647	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1288394013648	ligand binding site [chemical binding]; other site
1288394013649	calcium binding site [ion binding]; other site
1288394013650	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
1288394013651	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1288394013652	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1288394013653	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1288394013654	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1288394013655	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
1288394013656	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1288394013657	DNA binding site [nucleotide binding]
1288394013658	domain linker motif; other site
1288394013659	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
1288394013660	dimerization interface (closed form) [polypeptide binding]; other site
1288394013661	ligand binding site [chemical binding]; other site
1288394013662	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1288394013663	UDP-glucose 4-epimerase; Region: PLN02240
1288394013664	NAD binding site [chemical binding]; other site
1288394013665	homodimer interface [polypeptide binding]; other site
1288394013666	active site
1288394013667	substrate binding site [chemical binding]; other site
1288394013668	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
1288394013669	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
1288394013670	dimer interface [polypeptide binding]; other site
1288394013671	active site
1288394013672	galactokinase; Provisional; Region: PRK05101
1288394013673	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1288394013674	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1288394013675	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1288394013676	active site
1288394013677	catalytic residues [active]
1288394013678	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1288394013679	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1288394013680	active site
1288394013681	catalytic tetrad [active]
1288394013682	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1288394013683	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
1288394013684	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1288394013685	RNA polymerase sigma factor; Provisional; Region: PRK11924
1288394013686	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1288394013687	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1288394013688	DNA binding residues [nucleotide binding]
1288394013689	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
1288394013690	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
1288394013691	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1288394013692	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1288394013693	active site
1288394013694	HIGH motif; other site
1288394013695	KMSK motif region; other site
1288394013696	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1288394013697	tRNA binding surface [nucleotide binding]; other site
1288394013698	anticodon binding site; other site
1288394013699	Sporulation related domain; Region: SPOR; pfam05036
1288394013700	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1288394013701	active site
1288394013702	HslU subunit interaction site [polypeptide binding]; other site
1288394013703	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1288394013704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394013705	Walker A motif; other site
1288394013706	ATP binding site [chemical binding]; other site
1288394013707	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1288394013708	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1288394013709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1288394013710	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1288394013711	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1288394013712	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1288394013713	putative substrate binding pocket [chemical binding]; other site
1288394013714	putative dimerization interface [polypeptide binding]; other site
1288394013715	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1288394013716	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1288394013717	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1288394013718	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1288394013719	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1288394013720	nitrite transporter NirC; Provisional; Region: PRK11562
1288394013721	siroheme synthase; Provisional; Region: cysG; PRK10637
1288394013722	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1288394013723	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
1288394013724	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1288394013725	active site
1288394013726	SAM binding site [chemical binding]; other site
1288394013727	homodimer interface [polypeptide binding]; other site
1288394013728	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1288394013729	MgtE intracellular N domain; Region: MgtE_N; smart00924
1288394013730	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1288394013731	Divalent cation transporter; Region: MgtE; cl00786
1288394013732	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1288394013733	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1288394013734	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1288394013735	dimer interface [polypeptide binding]; other site
1288394013736	putative CheW interface [polypeptide binding]; other site
1288394013737	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1288394013738	hypothetical protein; Provisional; Region: PRK11212
1288394013739	Protein of unknown function (DUF3630); Region: DUF3630; pfam12305
1288394013740	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1288394013741	hypothetical protein; Validated; Region: PRK00029
1288394013742	Cytochrome c; Region: Cytochrom_C; cl11414
1288394013743	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
1288394013744	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394013745	ATP binding site [chemical binding]; other site
1288394013746	putative Mg++ binding site [ion binding]; other site
1288394013747	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1288394013748	nucleotide binding region [chemical binding]; other site
1288394013749	ATP-binding site [chemical binding]; other site
1288394013750	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1288394013751	HRDC domain; Region: HRDC; pfam00570
1288394013752	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1288394013753	CoenzymeA binding site [chemical binding]; other site
1288394013754	subunit interaction site [polypeptide binding]; other site
1288394013755	PHB binding site; other site
1288394013756	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1288394013757	MOSC domain; Region: MOSC; pfam03473
1288394013758	3-alpha domain; Region: 3-alpha; pfam03475
1288394013759	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1288394013760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394013761	dimer interface [polypeptide binding]; other site
1288394013762	conserved gate region; other site
1288394013763	putative PBP binding loops; other site
1288394013764	ABC-ATPase subunit interface; other site
1288394013765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394013766	dimer interface [polypeptide binding]; other site
1288394013767	conserved gate region; other site
1288394013768	putative PBP binding loops; other site
1288394013769	ABC-ATPase subunit interface; other site
1288394013770	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
1288394013771	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394013772	Walker A/P-loop; other site
1288394013773	ATP binding site [chemical binding]; other site
1288394013774	Q-loop/lid; other site
1288394013775	ABC transporter signature motif; other site
1288394013776	Walker B; other site
1288394013777	D-loop; other site
1288394013778	H-loop/switch region; other site
1288394013779	TOBE domain; Region: TOBE_2; pfam08402
1288394013780	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1288394013781	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1288394013782	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1288394013783	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1288394013784	putative aminotransferase; Validated; Region: PRK07480
1288394013785	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1288394013786	inhibitor-cofactor binding pocket; inhibition site
1288394013787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394013788	catalytic residue [active]
1288394013789	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1288394013790	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1288394013791	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1288394013792	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394013793	Protein of unknown function (DUF962); Region: DUF962; cl01879
1288394013794	CreA protein; Region: CreA; pfam05981
1288394013795	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1288394013796	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1288394013797	putative ligand binding site [chemical binding]; other site
1288394013798	putative NAD binding site [chemical binding]; other site
1288394013799	catalytic site [active]
1288394013800	putative chaperone; Provisional; Region: PRK11678
1288394013801	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1288394013802	nucleotide binding site [chemical binding]; other site
1288394013803	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1288394013804	SBD interface [polypeptide binding]; other site
1288394013805	META domain; Region: META; pfam03724
1288394013806	HDOD domain; Region: HDOD; pfam08668
1288394013807	HD domain; Region: HD; pfam01966
1288394013808	maltodextrin glucosidase; Provisional; Region: PRK10785
1288394013809	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1288394013810	homodimer interface [polypeptide binding]; other site
1288394013811	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1288394013812	active site
1288394013813	homodimer interface [polypeptide binding]; other site
1288394013814	catalytic site [active]
1288394013815	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1288394013816	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1288394013817	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
1288394013818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1288394013819	S-adenosylmethionine binding site [chemical binding]; other site
1288394013820	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
1288394013821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394013822	active site
1288394013823	phosphorylation site [posttranslational modification]
1288394013824	intermolecular recognition site; other site
1288394013825	dimerization interface [polypeptide binding]; other site
1288394013826	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394013827	DNA binding site [nucleotide binding]
1288394013828	sensor protein RstB; Provisional; Region: PRK10604
1288394013829	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1288394013830	dimerization interface [polypeptide binding]; other site
1288394013831	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394013832	dimer interface [polypeptide binding]; other site
1288394013833	phosphorylation site [posttranslational modification]
1288394013834	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394013835	ATP binding site [chemical binding]; other site
1288394013836	Mg2+ binding site [ion binding]; other site
1288394013837	G-X-G motif; other site
1288394013838	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1288394013839	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1288394013840	putative NAD(P) binding site [chemical binding]; other site
1288394013841	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1288394013842	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1288394013843	NAD(P) binding site [chemical binding]; other site
1288394013844	active site
1288394013845	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1288394013846	primosome assembly protein PriA; Validated; Region: PRK05580
1288394013847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1288394013848	ATP binding site [chemical binding]; other site
1288394013849	putative Mg++ binding site [ion binding]; other site
1288394013850	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1288394013851	outer membrane protein A; Reviewed; Region: PRK10808
1288394013852	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
1288394013853	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1288394013854	ligand binding site [chemical binding]; other site
1288394013855	threonine dehydratase; Reviewed; Region: PRK09224
1288394013856	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1288394013857	tetramer interface [polypeptide binding]; other site
1288394013858	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394013859	catalytic residue [active]
1288394013860	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1288394013861	putative Ile/Val binding site [chemical binding]; other site
1288394013862	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1288394013863	putative Ile/Val binding site [chemical binding]; other site
1288394013864	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1288394013865	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1288394013866	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1288394013867	homodimer interface [polypeptide binding]; other site
1288394013868	substrate-cofactor binding pocket; other site
1288394013869	catalytic residue [active]
1288394013870	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
1288394013871	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
1288394013872	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1288394013873	PYR/PP interface [polypeptide binding]; other site
1288394013874	dimer interface [polypeptide binding]; other site
1288394013875	TPP binding site [chemical binding]; other site
1288394013876	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1288394013877	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1288394013878	TPP-binding site [chemical binding]; other site
1288394013879	dimer interface [polypeptide binding]; other site
1288394013880	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1288394013881	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1288394013882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1288394013883	Walker A motif; other site
1288394013884	ATP binding site [chemical binding]; other site
1288394013885	Walker B motif; other site
1288394013886	arginine finger; other site
1288394013887	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1288394013888	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1288394013889	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1288394013890	putative acyl-acceptor binding pocket; other site
1288394013891	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1288394013892	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
1288394013893	putative acyl-acceptor binding pocket; other site
1288394013894	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1288394013895	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1288394013896	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1288394013897	Isochorismatase family; Region: Isochorismatase; pfam00857
1288394013898	catalytic triad [active]
1288394013899	metal binding site [ion binding]; metal-binding site
1288394013900	conserved cis-peptide bond; other site
1288394013901	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
1288394013902	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
1288394013903	active site
1288394013904	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1288394013905	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394013906	substrate binding pocket [chemical binding]; other site
1288394013907	membrane-bound complex binding site; other site
1288394013908	hinge residues; other site
1288394013909	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1288394013910	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
1288394013911	Walker A/P-loop; other site
1288394013912	ATP binding site [chemical binding]; other site
1288394013913	Q-loop/lid; other site
1288394013914	ABC transporter signature motif; other site
1288394013915	Walker B; other site
1288394013916	D-loop; other site
1288394013917	H-loop/switch region; other site
1288394013918	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1288394013919	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1288394013920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1288394013921	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
1288394013922	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1288394013923	catalytic residues [active]
1288394013924	hinge region; other site
1288394013925	alpha helical domain; other site
1288394013926	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1288394013927	serine/threonine protein kinase; Provisional; Region: PRK11768
1288394013928	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1288394013929	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1288394013930	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1288394013931	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1288394013932	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
1288394013933	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394013934	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394013935	metal binding site [ion binding]; metal-binding site
1288394013936	active site
1288394013937	I-site; other site
1288394013938	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1288394013939	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1288394013940	DNA binding residues [nucleotide binding]
1288394013941	dimer interface [polypeptide binding]; other site
1288394013942	copper binding site [ion binding]; other site
1288394013943	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1288394013944	metal-binding site [ion binding]
1288394013945	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1288394013946	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1288394013947	metal-binding site [ion binding]
1288394013948	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1288394013949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1288394013950	motif II; other site
1288394013951	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1288394013952	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1288394013953	active site
1288394013954	ribonuclease PH; Reviewed; Region: rph; PRK00173
1288394013955	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1288394013956	hexamer interface [polypeptide binding]; other site
1288394013957	active site
1288394013958	hypothetical protein; Provisional; Region: PRK11820
1288394013959	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1288394013960	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1288394013961	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394013962	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1288394013963	putative active site [active]
1288394013964	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394013965	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394013966	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1288394013967	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1288394013968	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1288394013969	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1288394013970	O-Antigen ligase; Region: Wzy_C; pfam04932
1288394013971	This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819
1288394013972	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1288394013973	putative ADP-binding pocket [chemical binding]; other site
1288394013974	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1288394013975	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1288394013976	putative active site [active]
1288394013977	putative metal binding site [ion binding]; other site
1288394013978	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
1288394013979	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
1288394013980	NADP binding site [chemical binding]; other site
1288394013981	homopentamer interface [polypeptide binding]; other site
1288394013982	substrate binding site [chemical binding]; other site
1288394013983	active site
1288394013984	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1288394013985	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1288394013986	Bacterial transcriptional repressor; Region: TetR; pfam13972
1288394013987	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1288394013988	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1288394013989	substrate-cofactor binding pocket; other site
1288394013990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1288394013991	catalytic residue [active]
1288394013992	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1288394013993	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1288394013994	NAD(P) binding site [chemical binding]; other site
1288394013995	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
1288394013996	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1288394013997	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1288394013998	metal binding site [ion binding]; metal-binding site
1288394013999	active site
1288394014000	I-site; other site
1288394014001	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1288394014002	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
1288394014003	Part of AAA domain; Region: AAA_19; pfam13245
1288394014004	Family description; Region: UvrD_C_2; pfam13538
1288394014005	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1288394014006	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1288394014007	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1288394014008	catalytic residue [active]
1288394014009	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1288394014010	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1288394014011	putative ATP binding site [chemical binding]; other site
1288394014012	putative substrate interface [chemical binding]; other site
1288394014013	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1288394014014	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1288394014015	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1288394014016	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1288394014017	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
1288394014018	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
1288394014019	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
1288394014020	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1288394014021	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1288394014022	DNA binding residues [nucleotide binding]
1288394014023	dimerization interface [polypeptide binding]; other site
1288394014024	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1288394014025	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1288394014026	glutaminase active site [active]
1288394014027	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1288394014028	dimer interface [polypeptide binding]; other site
1288394014029	active site
1288394014030	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1288394014031	dimer interface [polypeptide binding]; other site
1288394014032	active site
1288394014033	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
1288394014034	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1288394014035	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1288394014036	DNA-binding response regulator CreB; Provisional; Region: PRK11083
1288394014037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1288394014038	active site
1288394014039	phosphorylation site [posttranslational modification]
1288394014040	intermolecular recognition site; other site
1288394014041	dimerization interface [polypeptide binding]; other site
1288394014042	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1288394014043	DNA binding site [nucleotide binding]
1288394014044	sensory histidine kinase CreC; Provisional; Region: PRK11100
1288394014045	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1288394014046	dimer interface [polypeptide binding]; other site
1288394014047	phosphorylation site [posttranslational modification]
1288394014048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1288394014049	ATP binding site [chemical binding]; other site
1288394014050	Mg2+ binding site [ion binding]; other site
1288394014051	G-X-G motif; other site
1288394014052	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1288394014053	inner membrane protein; Provisional; Region: PRK11715
1288394014054	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
1288394014055	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1288394014056	Substrate binding site; other site
1288394014057	Mg++ binding site; other site
1288394014058	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1288394014059	active site
1288394014060	substrate binding site [chemical binding]; other site
1288394014061	CoA binding site [chemical binding]; other site
1288394014062	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1288394014063	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1288394014064	gamma subunit interface [polypeptide binding]; other site
1288394014065	epsilon subunit interface [polypeptide binding]; other site
1288394014066	LBP interface [polypeptide binding]; other site
1288394014067	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1288394014068	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1288394014069	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1288394014070	alpha subunit interaction interface [polypeptide binding]; other site
1288394014071	Walker A motif; other site
1288394014072	ATP binding site [chemical binding]; other site
1288394014073	Walker B motif; other site
1288394014074	inhibitor binding site; inhibition site
1288394014075	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1288394014076	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1288394014077	core domain interface [polypeptide binding]; other site
1288394014078	delta subunit interface [polypeptide binding]; other site
1288394014079	epsilon subunit interface [polypeptide binding]; other site
1288394014080	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1288394014081	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1288394014082	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1288394014083	beta subunit interaction interface [polypeptide binding]; other site
1288394014084	Walker A motif; other site
1288394014085	ATP binding site [chemical binding]; other site
1288394014086	Walker B motif; other site
1288394014087	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1288394014088	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1288394014089	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1288394014090	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1288394014091	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1288394014092	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1288394014093	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1288394014094	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1288394014095	ATP synthase I chain; Region: ATP_synt_I; cl09170
1288394014096	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1288394014097	ParB-like nuclease domain; Region: ParB; smart00470
1288394014098	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1288394014099	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1288394014100	P-loop; other site
1288394014101	Magnesium ion binding site [ion binding]; other site
1288394014102	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1288394014103	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1288394014104	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1288394014105	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1288394014106	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1288394014107	FMN-binding protein MioC; Provisional; Region: PRK09004
1288394014108	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1288394014109	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1288394014110	N-terminal plug; other site
1288394014111	ligand-binding site [chemical binding]; other site
1288394014112	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
1288394014113	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1288394014114	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1288394014115	Walker A/P-loop; other site
1288394014116	ATP binding site [chemical binding]; other site
1288394014117	Q-loop/lid; other site
1288394014118	ABC transporter signature motif; other site
1288394014119	Walker B; other site
1288394014120	D-loop; other site
1288394014121	H-loop/switch region; other site
1288394014122	iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575
1288394014123	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1288394014124	Walker A/P-loop; other site
1288394014125	ATP binding site [chemical binding]; other site
1288394014126	Q-loop/lid; other site
1288394014127	ABC transporter signature motif; other site
1288394014128	Walker B; other site
1288394014129	D-loop; other site
1288394014130	H-loop/switch region; other site
1288394014131	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1288394014132	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1288394014133	siderophore binding site; other site
1288394014134	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1288394014135	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394014136	ABC-ATPase subunit  interface; other site
1288394014137	dimer interface [polypeptide binding]; other site
1288394014138	putative PBP binding regions; other site
1288394014139	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1288394014140	ABC-ATPase subunit  interface; other site
1288394014141	dimer interface [polypeptide binding]; other site
1288394014142	putative PBP binding regions; other site
1288394014143	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1288394014144	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1288394014145	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1288394014146	G1 box; other site
1288394014147	GTP/Mg2+ binding site [chemical binding]; other site
1288394014148	Switch I region; other site
1288394014149	G2 box; other site
1288394014150	Switch II region; other site
1288394014151	G3 box; other site
1288394014152	G4 box; other site
1288394014153	G5 box; other site
1288394014154	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1288394014155	membrane protein insertase; Provisional; Region: PRK01318
1288394014156	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1288394014157	Haemolytic domain; Region: Haemolytic; pfam01809
1288394014158	ribonuclease P; Reviewed; Region: rnpA; PRK01732
1288394014159	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1288394014160	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1288394014161	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1288394014162	Walker A/P-loop; other site
1288394014163	ATP binding site [chemical binding]; other site
1288394014164	Q-loop/lid; other site
1288394014165	ABC transporter signature motif; other site
1288394014166	Walker B; other site
1288394014167	D-loop; other site
1288394014168	H-loop/switch region; other site
1288394014169	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1288394014170	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1288394014171	dimer interface [polypeptide binding]; other site
1288394014172	conserved gate region; other site
1288394014173	putative PBP binding loops; other site
1288394014174	ABC-ATPase subunit interface; other site
1288394014175	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1288394014176	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1288394014177	substrate binding pocket [chemical binding]; other site
1288394014178	membrane-bound complex binding site; other site
1288394014179	hinge residues; other site