-- dump date 20140618_192457 -- class Genbank::misc_feature -- table misc_feature_note -- id note 754507000001 ParA-like protein; Provisional; Region: PHA02518 754507000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754507000003 Magnesium ion binding site [ion binding]; other site 754507000004 ABC transporter; Provisional; Region: PTZ00243 754507000005 Fic family protein [Function unknown]; Region: COG3177 754507000006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754507000007 ligand binding site [chemical binding]; other site 754507000008 translocation protein TolB; Provisional; Region: tolB; PRK01742 754507000009 TolB amino-terminal domain; Region: TolB_N; pfam04052 754507000010 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754507000011 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754507000012 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 754507000013 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 754507000014 TolA C-terminal; Region: TolA; pfam06519 754507000015 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 754507000016 colicin uptake protein TolR; Provisional; Region: PRK11024 754507000017 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 754507000018 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754507000019 active site 754507000020 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 754507000021 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 754507000022 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 754507000023 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 754507000024 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 754507000025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507000026 Walker A motif; other site 754507000027 ATP binding site [chemical binding]; other site 754507000028 Walker B motif; other site 754507000029 arginine finger; other site 754507000030 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 754507000031 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 754507000032 RuvA N terminal domain; Region: RuvA_N; pfam01330 754507000033 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 754507000034 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 754507000035 active site 754507000036 putative DNA-binding cleft [nucleotide binding]; other site 754507000037 dimer interface [polypeptide binding]; other site 754507000038 hypothetical protein; Validated; Region: PRK00110 754507000039 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 754507000040 nudix motif; other site 754507000041 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 754507000042 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 754507000043 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 754507000044 dimer interface [polypeptide binding]; other site 754507000045 anticodon binding site; other site 754507000046 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 754507000047 homodimer interface [polypeptide binding]; other site 754507000048 motif 1; other site 754507000049 active site 754507000050 motif 2; other site 754507000051 GAD domain; Region: GAD; pfam02938 754507000052 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754507000053 active site 754507000054 motif 3; other site 754507000055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 754507000056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507000057 S-adenosylmethionine binding site [chemical binding]; other site 754507000058 Predicted membrane protein [Function unknown]; Region: COG4984 754507000059 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 754507000060 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 754507000061 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 754507000062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507000063 putative substrate translocation pore; other site 754507000064 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 754507000065 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754507000066 N-terminal plug; other site 754507000067 ligand-binding site [chemical binding]; other site 754507000068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 754507000069 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 754507000070 dimer interface [polypeptide binding]; other site 754507000071 active site 754507000072 metal binding site [ion binding]; metal-binding site 754507000073 glutathione binding site [chemical binding]; other site 754507000074 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 754507000075 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 754507000076 dimer interface [polypeptide binding]; other site 754507000077 catalytic site [active] 754507000078 putative active site [active] 754507000079 putative substrate binding site [chemical binding]; other site 754507000080 Predicted permease [General function prediction only]; Region: COG2056 754507000081 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 754507000082 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 754507000083 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 754507000084 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 754507000085 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754507000086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000087 FeS/SAM binding site; other site 754507000088 TRAM domain; Region: TRAM; pfam01938 754507000089 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 754507000090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 754507000091 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754507000092 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754507000093 substrate binding pocket [chemical binding]; other site 754507000094 chain length determination region; other site 754507000095 substrate-Mg2+ binding site; other site 754507000096 catalytic residues [active] 754507000097 aspartate-rich region 1; other site 754507000098 active site lid residues [active] 754507000099 aspartate-rich region 2; other site 754507000100 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 754507000101 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 754507000102 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 754507000103 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754507000104 EamA-like transporter family; Region: EamA; pfam00892 754507000105 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754507000106 EamA-like transporter family; Region: EamA; pfam00892 754507000107 EamA-like transporter family; Region: EamA; pfam00892 754507000108 GTPase CgtA; Reviewed; Region: obgE; PRK12298 754507000109 GTP1/OBG; Region: GTP1_OBG; pfam01018 754507000110 Obg GTPase; Region: Obg; cd01898 754507000111 G1 box; other site 754507000112 GTP/Mg2+ binding site [chemical binding]; other site 754507000113 Switch I region; other site 754507000114 G2 box; other site 754507000115 G3 box; other site 754507000116 Switch II region; other site 754507000117 G4 box; other site 754507000118 G5 box; other site 754507000119 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 754507000120 SmpB-tmRNA interface; other site 754507000121 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 754507000122 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 754507000123 peptide binding site [polypeptide binding]; other site 754507000124 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 754507000125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507000126 dimer interface [polypeptide binding]; other site 754507000127 conserved gate region; other site 754507000128 putative PBP binding loops; other site 754507000129 ABC-ATPase subunit interface; other site 754507000130 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 754507000131 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754507000132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507000133 dimer interface [polypeptide binding]; other site 754507000134 conserved gate region; other site 754507000135 ABC-ATPase subunit interface; other site 754507000136 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 754507000137 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754507000138 Walker A/P-loop; other site 754507000139 ATP binding site [chemical binding]; other site 754507000140 Q-loop/lid; other site 754507000141 ABC transporter signature motif; other site 754507000142 Walker B; other site 754507000143 D-loop; other site 754507000144 H-loop/switch region; other site 754507000145 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 754507000146 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 754507000147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754507000148 Walker A/P-loop; other site 754507000149 ATP binding site [chemical binding]; other site 754507000150 Q-loop/lid; other site 754507000151 ABC transporter signature motif; other site 754507000152 Walker B; other site 754507000153 D-loop; other site 754507000154 H-loop/switch region; other site 754507000155 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 754507000156 two-component response regulator; Provisional; Region: PRK11173 754507000157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754507000158 active site 754507000159 phosphorylation site [posttranslational modification] 754507000160 intermolecular recognition site; other site 754507000161 dimerization interface [polypeptide binding]; other site 754507000162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754507000163 DNA binding site [nucleotide binding] 754507000164 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 754507000165 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 754507000166 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 754507000167 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 754507000168 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 754507000169 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 754507000170 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 754507000171 DsbD alpha interface [polypeptide binding]; other site 754507000172 catalytic residues [active] 754507000173 Predicted membrane protein [Function unknown]; Region: COG2259 754507000174 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 754507000175 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 754507000176 homodimer interface [polypeptide binding]; other site 754507000177 oligonucleotide binding site [chemical binding]; other site 754507000178 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 754507000179 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 754507000180 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507000181 RNA binding surface [nucleotide binding]; other site 754507000182 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754507000183 active site 754507000184 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 754507000185 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 754507000186 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 754507000187 putative ligand binding site [chemical binding]; other site 754507000188 putative NAD binding site [chemical binding]; other site 754507000189 catalytic site [active] 754507000190 cystathionine gamma-synthase; Reviewed; Region: PRK08247 754507000191 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754507000192 homodimer interface [polypeptide binding]; other site 754507000193 substrate-cofactor binding pocket; other site 754507000194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507000195 catalytic residue [active] 754507000196 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754507000197 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754507000198 catalytic residue [active] 754507000199 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 754507000200 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 754507000201 VirB7 interaction site; other site 754507000202 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 754507000203 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 754507000204 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754507000205 ATP binding site [chemical binding]; other site 754507000206 Walker A motif; other site 754507000207 hexamer interface [polypeptide binding]; other site 754507000208 Walker B motif; other site 754507000209 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 754507000210 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 754507000211 putative catalytic cysteine [active] 754507000212 Predicted membrane protein [Function unknown]; Region: COG2860 754507000213 UPF0126 domain; Region: UPF0126; pfam03458 754507000214 UPF0126 domain; Region: UPF0126; pfam03458 754507000215 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 754507000216 AMP binding site [chemical binding]; other site 754507000217 metal binding site [ion binding]; metal-binding site 754507000218 active site 754507000219 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 754507000220 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754507000221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754507000222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754507000223 murein transglycosylase A; Provisional; Region: mltA; PRK11162 754507000224 MltA specific insert domain; Region: MltA; smart00925 754507000225 3D domain; Region: 3D; pfam06725 754507000226 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 754507000227 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 754507000228 putative ATP binding site [chemical binding]; other site 754507000229 putative substrate interface [chemical binding]; other site 754507000230 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 754507000231 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 754507000232 metal binding site [ion binding]; metal-binding site 754507000233 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 754507000234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 754507000235 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 754507000236 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 754507000237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507000238 motif II; other site 754507000239 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 754507000240 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 754507000241 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 754507000242 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 754507000243 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 754507000244 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 754507000245 active site 754507000246 Riboflavin kinase; Region: Flavokinase; smart00904 754507000247 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 754507000248 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 754507000249 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754507000250 active site 754507000251 HIGH motif; other site 754507000252 nucleotide binding site [chemical binding]; other site 754507000253 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 754507000254 active site 754507000255 KMSKS motif; other site 754507000256 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 754507000257 tRNA binding surface [nucleotide binding]; other site 754507000258 anticodon binding site; other site 754507000259 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754507000260 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 754507000261 lipoprotein signal peptidase; Provisional; Region: PRK14787 754507000262 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 754507000263 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 754507000264 trigger factor; Provisional; Region: tig; PRK01490 754507000265 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754507000266 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 754507000267 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 754507000268 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 754507000269 active site 754507000270 Int/Topo IB signature motif; other site 754507000271 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 754507000272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507000273 putative substrate translocation pore; other site 754507000274 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 754507000275 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 754507000276 recombination associated protein; Reviewed; Region: rdgC; PRK00321 754507000277 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 754507000278 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 754507000279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000280 FeS/SAM binding site; other site 754507000281 elongation factor P; Validated; Region: PRK00529 754507000282 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 754507000283 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 754507000284 RNA binding site [nucleotide binding]; other site 754507000285 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 754507000286 RNA binding site [nucleotide binding]; other site 754507000287 tyrosine phenol-lyase; Provisional; Region: PRK13237 754507000288 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 754507000289 substrate binding site [chemical binding]; other site 754507000290 tetramer interface [polypeptide binding]; other site 754507000291 catalytic residue [active] 754507000292 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 754507000293 aromatic amino acid transport protein; Region: araaP; TIGR00837 754507000294 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 754507000295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754507000296 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 754507000297 putative active site [active] 754507000298 putative metal binding site [ion binding]; other site 754507000299 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 754507000300 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754507000301 putative acyl-acceptor binding pocket; other site 754507000302 FtsI repressor; Provisional; Region: PRK10883 754507000303 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 754507000304 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754507000305 EamA-like transporter family; Region: EamA; pfam00892 754507000306 EamA-like transporter family; Region: EamA; pfam00892 754507000307 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 754507000308 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000309 FeS/SAM binding site; other site 754507000310 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 754507000311 Pyruvate formate lyase 1; Region: PFL1; cd01678 754507000312 coenzyme A binding site [chemical binding]; other site 754507000313 active site 754507000314 catalytic residues [active] 754507000315 glycine loop; other site 754507000316 formate transporter FocA; Region: formate_focA; TIGR04060 754507000317 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 754507000318 nucleotide binding site/active site [active] 754507000319 HIT family signature motif; other site 754507000320 catalytic residue [active] 754507000321 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 754507000322 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 754507000323 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 754507000324 putative dimer interface [polypeptide binding]; other site 754507000325 beta-hexosaminidase; Provisional; Region: PRK05337 754507000326 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 754507000327 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 754507000328 Methyltransferase domain; Region: Methyltransf_26; pfam13659 754507000329 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 754507000330 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 754507000331 active site 754507000332 ADP/pyrophosphate binding site [chemical binding]; other site 754507000333 dimerization interface [polypeptide binding]; other site 754507000334 allosteric effector site; other site 754507000335 fructose-1,6-bisphosphate binding site; other site 754507000336 Cation efflux family; Region: Cation_efflux; cl00316 754507000337 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 754507000338 hypothetical protein; Validated; Region: PRK02101 754507000339 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 754507000340 ligand binding site [chemical binding]; other site 754507000341 active site 754507000342 UGI interface [polypeptide binding]; other site 754507000343 catalytic site [active] 754507000344 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 754507000345 GTP-binding protein LepA; Provisional; Region: PRK05433 754507000346 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 754507000347 G1 box; other site 754507000348 putative GEF interaction site [polypeptide binding]; other site 754507000349 GTP/Mg2+ binding site [chemical binding]; other site 754507000350 Switch I region; other site 754507000351 G2 box; other site 754507000352 G3 box; other site 754507000353 Switch II region; other site 754507000354 G4 box; other site 754507000355 G5 box; other site 754507000356 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 754507000357 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 754507000358 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 754507000359 signal peptidase I; Provisional; Region: PRK10861 754507000360 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754507000361 Catalytic site [active] 754507000362 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 754507000363 Catalytic site [active] 754507000364 ribonuclease III; Reviewed; Region: rnc; PRK00102 754507000365 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 754507000366 dimerization interface [polypeptide binding]; other site 754507000367 active site 754507000368 metal binding site [ion binding]; metal-binding site 754507000369 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 754507000370 dsRNA binding site [nucleotide binding]; other site 754507000371 GTPase Era; Reviewed; Region: era; PRK00089 754507000372 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 754507000373 G1 box; other site 754507000374 GTP/Mg2+ binding site [chemical binding]; other site 754507000375 Switch I region; other site 754507000376 G2 box; other site 754507000377 Switch II region; other site 754507000378 G3 box; other site 754507000379 G4 box; other site 754507000380 G5 box; other site 754507000381 KH domain; Region: KH_2; pfam07650 754507000382 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 754507000383 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 754507000384 trmE is a tRNA modification GTPase; Region: trmE; cd04164 754507000385 G1 box; other site 754507000386 GTP/Mg2+ binding site [chemical binding]; other site 754507000387 Switch I region; other site 754507000388 G2 box; other site 754507000389 Switch II region; other site 754507000390 G3 box; other site 754507000391 G4 box; other site 754507000392 G5 box; other site 754507000393 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 754507000394 membrane protein insertase; Provisional; Region: PRK01318 754507000395 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 754507000396 ribonuclease P; Reviewed; Region: rnpA; PRK01732 754507000397 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 754507000398 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 754507000399 DnaA N-terminal domain; Region: DnaA_N; pfam11638 754507000400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507000401 Walker B motif; other site 754507000402 arginine finger; other site 754507000403 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 754507000404 DnaA box-binding interface [nucleotide binding]; other site 754507000405 DNA polymerase III subunit beta; Validated; Region: PRK05643 754507000406 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 754507000407 putative DNA binding surface [nucleotide binding]; other site 754507000408 dimer interface [polypeptide binding]; other site 754507000409 beta-clamp/clamp loader binding surface; other site 754507000410 beta-clamp/translesion DNA polymerase binding surface; other site 754507000411 recF protein; Region: recf; TIGR00611 754507000412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507000413 Walker A/P-loop; other site 754507000414 ATP binding site [chemical binding]; other site 754507000415 Q-loop/lid; other site 754507000416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507000417 ABC transporter signature motif; other site 754507000418 Walker B; other site 754507000419 D-loop; other site 754507000420 H-loop/switch region; other site 754507000421 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754507000422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507000423 S-adenosylmethionine binding site [chemical binding]; other site 754507000424 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 754507000425 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 754507000426 E-class dimer interface [polypeptide binding]; other site 754507000427 P-class dimer interface [polypeptide binding]; other site 754507000428 active site 754507000429 Cu2+ binding site [ion binding]; other site 754507000430 Zn2+ binding site [ion binding]; other site 754507000431 Homeodomain-like domain; Region: HTH_23; cl17451 754507000432 putative transposase OrfB; Reviewed; Region: PHA02517 754507000433 HTH-like domain; Region: HTH_21; pfam13276 754507000434 Integrase core domain; Region: rve; pfam00665 754507000435 Integrase core domain; Region: rve_2; pfam13333 754507000436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754507000437 non-specific DNA binding site [nucleotide binding]; other site 754507000438 salt bridge; other site 754507000439 sequence-specific DNA binding site [nucleotide binding]; other site 754507000440 malate dehydrogenase; Provisional; Region: PRK13529 754507000441 Malic enzyme, N-terminal domain; Region: malic; pfam00390 754507000442 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 754507000443 NAD(P) binding site [chemical binding]; other site 754507000444 Predicted flavoproteins [General function prediction only]; Region: COG2081 754507000445 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754507000446 cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147 754507000447 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 754507000448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754507000449 binding surface 754507000450 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 754507000451 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754507000452 catalytic residues [active] 754507000453 central insert; other site 754507000454 cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145 754507000455 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 754507000456 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 754507000457 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 754507000458 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 754507000459 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 754507000460 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 754507000461 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 754507000462 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 754507000463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 754507000464 TPR motif; other site 754507000465 binding surface 754507000466 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 754507000467 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 754507000468 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 754507000469 catalytic residues [active] 754507000470 central insert; other site 754507000471 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 754507000472 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 754507000473 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 754507000474 heme exporter protein CcmC; Region: ccmC; TIGR01191 754507000475 heme exporter protein CcmB; Region: ccmB; TIGR01190 754507000476 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 754507000477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507000478 Walker A/P-loop; other site 754507000479 ATP binding site [chemical binding]; other site 754507000480 Q-loop/lid; other site 754507000481 ABC transporter signature motif; other site 754507000482 Walker B; other site 754507000483 D-loop; other site 754507000484 H-loop/switch region; other site 754507000485 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 754507000486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507000487 putative substrate translocation pore; other site 754507000488 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 754507000489 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507000490 RNA binding surface [nucleotide binding]; other site 754507000491 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 754507000492 active site 754507000493 uracil binding [chemical binding]; other site 754507000494 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 754507000495 Malic enzyme, N-terminal domain; Region: malic; pfam00390 754507000496 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 754507000497 putative NAD(P) binding site [chemical binding]; other site 754507000498 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 754507000499 superoxide dismutase; Provisional; Region: PRK10925 754507000500 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 754507000501 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 754507000502 Lipoprotein GNA1870 C terminal like; Region: Lipoprot_C; pfam08794 754507000503 Predicted metalloprotease [General function prediction only]; Region: COG2321 754507000504 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 754507000505 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 754507000506 BON domain; Region: BON; pfam04972 754507000507 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754507000508 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 754507000509 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 754507000510 homooctamer interface [polypeptide binding]; other site 754507000511 active site 754507000512 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 754507000513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754507000514 substrate binding pocket [chemical binding]; other site 754507000515 membrane-bound complex binding site; other site 754507000516 hinge residues; other site 754507000517 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754507000518 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754507000519 catalytic residue [active] 754507000520 disulfide bond formation protein B; Provisional; Region: PRK01749 754507000521 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 754507000522 fatty acid metabolism regulator; Provisional; Region: PRK04984 754507000523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754507000524 DNA-binding site [nucleotide binding]; DNA binding site 754507000525 FadR C-terminal domain; Region: FadR_C; pfam07840 754507000526 aminotransferase AlaT; Validated; Region: PRK09265 754507000527 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754507000528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507000529 homodimer interface [polypeptide binding]; other site 754507000530 catalytic residue [active] 754507000531 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 754507000532 chorismate binding enzyme; Region: Chorismate_bind; cl10555 754507000533 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 754507000534 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 754507000535 dimer interface [polypeptide binding]; other site 754507000536 tetramer interface [polypeptide binding]; other site 754507000537 PYR/PP interface [polypeptide binding]; other site 754507000538 TPP binding site [chemical binding]; other site 754507000539 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 754507000540 TPP-binding site; other site 754507000541 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 754507000542 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 754507000543 16S/18S rRNA binding site [nucleotide binding]; other site 754507000544 S13e-L30e interaction site [polypeptide binding]; other site 754507000545 25S rRNA binding site [nucleotide binding]; other site 754507000546 S-adenosylmethionine synthetase; Validated; Region: PRK05250 754507000547 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 754507000548 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 754507000549 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 754507000550 hypothetical protein; Provisional; Region: PRK04860 754507000551 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 754507000552 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 754507000553 serine transporter; Region: stp; TIGR00814 754507000554 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 754507000555 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 754507000556 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 754507000557 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 754507000558 active site 754507000559 homodimer interface [polypeptide binding]; other site 754507000560 homotetramer interface [polypeptide binding]; other site 754507000561 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 754507000562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000563 FeS/SAM binding site; other site 754507000564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754507000565 binding surface 754507000566 TPR motif; other site 754507000567 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 754507000568 Helix-turn-helix domain; Region: HTH_25; pfam13413 754507000569 non-specific DNA binding site [nucleotide binding]; other site 754507000570 salt bridge; other site 754507000571 sequence-specific DNA binding site [nucleotide binding]; other site 754507000572 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 754507000573 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 754507000574 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754507000575 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 754507000576 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 754507000577 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 754507000578 dimer interface [polypeptide binding]; other site 754507000579 motif 1; other site 754507000580 active site 754507000581 motif 2; other site 754507000582 motif 3; other site 754507000583 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 754507000584 anticodon binding site; other site 754507000585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 754507000586 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 754507000587 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 754507000588 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 754507000589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754507000590 uracil-xanthine permease; Region: ncs2; TIGR00801 754507000591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507000592 active site 754507000593 periplasmic folding chaperone; Provisional; Region: PRK10788 754507000594 SurA N-terminal domain; Region: SurA_N_3; cl07813 754507000595 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 754507000596 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 754507000597 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 754507000598 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754507000599 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 754507000600 Sulfatase; Region: Sulfatase; pfam00884 754507000601 Clp protease; Region: CLP_protease; pfam00574 754507000602 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 754507000603 oligomer interface [polypeptide binding]; other site 754507000604 active site residues [active] 754507000605 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 754507000606 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 754507000607 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 754507000608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507000609 Walker A motif; other site 754507000610 ATP binding site [chemical binding]; other site 754507000611 Walker B motif; other site 754507000612 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754507000613 Helix-turn-helix domain; Region: HTH_37; pfam13744 754507000614 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 754507000615 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 754507000616 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 754507000617 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754507000618 metal-binding site [ion binding] 754507000619 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 754507000620 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754507000621 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 754507000622 metal-binding site [ion binding] 754507000623 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 754507000624 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 754507000625 DNA binding residues [nucleotide binding] 754507000626 dimer interface [polypeptide binding]; other site 754507000627 copper binding site [ion binding]; other site 754507000628 Methyltransferase domain; Region: Methyltransf_26; pfam13659 754507000629 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 754507000630 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 754507000631 DEAD-like helicases superfamily; Region: DEXDc; smart00487 754507000632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507000633 ATP binding site [chemical binding]; other site 754507000634 putative Mg++ binding site [ion binding]; other site 754507000635 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 754507000636 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 754507000637 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 754507000638 homodimer interaction site [polypeptide binding]; other site 754507000639 cofactor binding site; other site 754507000640 RelB antitoxin; Region: RelB; cl01171 754507000641 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 754507000642 UbiA prenyltransferase family; Region: UbiA; pfam01040 754507000643 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 754507000644 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754507000645 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 754507000646 transmembrane helices; other site 754507000647 hypothetical protein; Provisional; Region: PRK05255 754507000648 peptidase PmbA; Provisional; Region: PRK11040 754507000649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507000650 active site 754507000651 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 754507000652 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 754507000653 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 754507000654 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 754507000655 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 754507000656 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 754507000657 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 754507000658 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 754507000659 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 754507000660 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754507000661 ATP binding site [chemical binding]; other site 754507000662 Mg++ binding site [ion binding]; other site 754507000663 motif III; other site 754507000664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507000665 nucleotide binding region [chemical binding]; other site 754507000666 ATP-binding site [chemical binding]; other site 754507000667 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 754507000668 putative RNA binding site [nucleotide binding]; other site 754507000669 lipoprotein NlpI; Provisional; Region: PRK11189 754507000670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754507000671 binding surface 754507000672 TPR motif; other site 754507000673 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 754507000674 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 754507000675 RNase E interface [polypeptide binding]; other site 754507000676 trimer interface [polypeptide binding]; other site 754507000677 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 754507000678 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 754507000679 RNase E interface [polypeptide binding]; other site 754507000680 trimer interface [polypeptide binding]; other site 754507000681 active site 754507000682 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 754507000683 putative nucleic acid binding region [nucleotide binding]; other site 754507000684 G-X-X-G motif; other site 754507000685 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 754507000686 RNA binding site [nucleotide binding]; other site 754507000687 domain interface; other site 754507000688 Domain of unknown function (DUF386); Region: DUF386; pfam04074 754507000689 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 754507000690 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 754507000691 amidase catalytic site [active] 754507000692 Zn binding residues [ion binding]; other site 754507000693 substrate binding site [chemical binding]; other site 754507000694 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 754507000695 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 754507000696 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 754507000697 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754507000698 Walker A motif; other site 754507000699 ATP binding site [chemical binding]; other site 754507000700 Walker B motif; other site 754507000701 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 754507000702 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754507000703 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754507000704 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 754507000705 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 754507000706 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 754507000707 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 754507000708 CoA-binding site [chemical binding]; other site 754507000709 ATP-binding [chemical binding]; other site 754507000710 Domain of unknown function (DUF329); Region: DUF329; cl01144 754507000711 Predicted acetyltransferase [General function prediction only]; Region: COG2388 754507000712 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 754507000713 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 754507000714 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 754507000715 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 754507000716 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 754507000717 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 754507000718 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754507000719 FMN binding site [chemical binding]; other site 754507000720 active site 754507000721 catalytic residues [active] 754507000722 substrate binding site [chemical binding]; other site 754507000723 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 754507000724 Methyltransferase domain; Region: Methyltransf_18; pfam12847 754507000725 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 754507000726 Fic/DOC family; Region: Fic; cl00960 754507000727 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 754507000728 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 754507000729 Na binding site [ion binding]; other site 754507000730 Predicted membrane protein [Function unknown]; Region: COG3924 754507000731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754507000732 TPR motif; other site 754507000733 binding surface 754507000734 Protein of unknown function (DUF560); Region: DUF560; pfam04575 754507000735 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 754507000736 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 754507000737 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 754507000738 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 754507000739 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 754507000740 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 754507000741 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754507000742 carboxyltransferase (CT) interaction site; other site 754507000743 biotinylation site [posttranslational modification]; other site 754507000744 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 754507000745 Dehydroquinase class II; Region: DHquinase_II; pfam01220 754507000746 active site 754507000747 trimer interface [polypeptide binding]; other site 754507000748 dimer interface [polypeptide binding]; other site 754507000749 O-succinylbenzoate synthase; Provisional; Region: PRK05105 754507000750 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 754507000751 active site 754507000752 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 754507000753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 754507000754 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 754507000755 substrate binding site [chemical binding]; other site 754507000756 oxyanion hole (OAH) forming residues; other site 754507000757 trimer interface [polypeptide binding]; other site 754507000758 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 754507000759 triosephosphate isomerase; Provisional; Region: PRK14567 754507000760 substrate binding site [chemical binding]; other site 754507000761 dimer interface [polypeptide binding]; other site 754507000762 catalytic triad [active] 754507000763 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 754507000764 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000765 FeS/SAM binding site; other site 754507000766 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 754507000767 Der GTPase activator; Provisional; Region: PRK05244 754507000768 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 754507000769 nucleoside/Zn binding site; other site 754507000770 dimer interface [polypeptide binding]; other site 754507000771 catalytic motif [active] 754507000772 thymidylate synthase; Reviewed; Region: thyA; PRK01827 754507000773 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 754507000774 dimerization interface [polypeptide binding]; other site 754507000775 active site 754507000776 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 754507000777 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 754507000778 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 754507000779 putative active site [active] 754507000780 Ap4A binding site [chemical binding]; other site 754507000781 nudix motif; other site 754507000782 putative metal binding site [ion binding]; other site 754507000783 D-ribose pyranase; Provisional; Region: PRK11797 754507000784 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 754507000785 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754507000786 Walker A/P-loop; other site 754507000787 ATP binding site [chemical binding]; other site 754507000788 Q-loop/lid; other site 754507000789 ABC transporter signature motif; other site 754507000790 Walker B; other site 754507000791 D-loop; other site 754507000792 H-loop/switch region; other site 754507000793 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754507000794 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507000795 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507000796 TM-ABC transporter signature motif; other site 754507000797 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 754507000798 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 754507000799 ligand binding site [chemical binding]; other site 754507000800 dimerization interface [polypeptide binding]; other site 754507000801 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754507000802 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 754507000803 substrate binding site [chemical binding]; other site 754507000804 dimer interface [polypeptide binding]; other site 754507000805 ATP binding site [chemical binding]; other site 754507000806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754507000807 DNA-binding site [nucleotide binding]; DNA binding site 754507000808 RNA-binding motif; other site 754507000809 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 754507000810 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 754507000811 argininosuccinate lyase; Provisional; Region: PRK04833 754507000812 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 754507000813 active sites [active] 754507000814 tetramer interface [polypeptide binding]; other site 754507000815 glutamate dehydrogenase; Provisional; Region: PRK09414 754507000816 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 754507000817 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 754507000818 NAD(P) binding site [chemical binding]; other site 754507000819 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 754507000820 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 754507000821 tetramer interface [polypeptide binding]; other site 754507000822 heme binding pocket [chemical binding]; other site 754507000823 NADPH binding site [chemical binding]; other site 754507000824 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 754507000825 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 754507000826 putative active site [active] 754507000827 putative PHP Thumb interface [polypeptide binding]; other site 754507000828 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 754507000829 generic binding surface I; other site 754507000830 generic binding surface II; other site 754507000831 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 754507000832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754507000833 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 754507000834 acyl-activating enzyme (AAE) consensus motif; other site 754507000835 putative AMP binding site [chemical binding]; other site 754507000836 putative active site [active] 754507000837 putative CoA binding site [chemical binding]; other site 754507000838 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 754507000839 trimer interface [polypeptide binding]; other site 754507000840 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 754507000841 trimer interface [polypeptide binding]; other site 754507000842 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 754507000843 trimer interface [polypeptide binding]; other site 754507000844 YadA-like C-terminal region; Region: YadA; pfam03895 754507000845 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 754507000846 ATP cone domain; Region: ATP-cone; pfam03477 754507000847 Class III ribonucleotide reductase; Region: RNR_III; cd01675 754507000848 effector binding site; other site 754507000849 active site 754507000850 Zn binding site [ion binding]; other site 754507000851 glycine loop; other site 754507000852 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 754507000853 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000854 FeS/SAM binding site; other site 754507000855 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 754507000856 active site 754507000857 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 754507000858 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 754507000859 substrate binding site [chemical binding]; other site 754507000860 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 754507000861 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754507000862 active site 754507000863 HIGH motif; other site 754507000864 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 754507000865 KMSKS motif; other site 754507000866 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 754507000867 tRNA binding surface [nucleotide binding]; other site 754507000868 anticodon binding site; other site 754507000869 lipoyl synthase; Provisional; Region: PRK05481 754507000870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507000871 FeS/SAM binding site; other site 754507000872 lipoate-protein ligase B; Provisional; Region: PRK14342 754507000873 hypothetical protein; Provisional; Region: PRK04998 754507000874 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 754507000875 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754507000876 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 754507000877 rare lipoprotein A; Region: rlpA; TIGR00413 754507000878 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 754507000879 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 754507000880 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 754507000881 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754507000882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754507000883 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 754507000884 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 754507000885 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 754507000886 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754507000887 ATP binding site [chemical binding]; other site 754507000888 Mg++ binding site [ion binding]; other site 754507000889 motif III; other site 754507000890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507000891 nucleotide binding region [chemical binding]; other site 754507000892 ATP-binding site [chemical binding]; other site 754507000893 transcription termination factor Rho; Provisional; Region: rho; PRK09376 754507000894 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 754507000895 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 754507000896 RNA binding site [nucleotide binding]; other site 754507000897 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 754507000898 multimer interface [polypeptide binding]; other site 754507000899 Walker A motif; other site 754507000900 ATP binding site [chemical binding]; other site 754507000901 Walker B motif; other site 754507000902 benzoate transport; Region: 2A0115; TIGR00895 754507000903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507000904 putative substrate translocation pore; other site 754507000905 acyl carrier protein; Provisional; Region: acpP; PRK00982 754507000906 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 754507000907 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 754507000908 NAD(P) binding site [chemical binding]; other site 754507000909 homotetramer interface [polypeptide binding]; other site 754507000910 homodimer interface [polypeptide binding]; other site 754507000911 active site 754507000912 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 754507000913 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 754507000914 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 754507000915 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 754507000916 dimer interface [polypeptide binding]; other site 754507000917 active site 754507000918 CoA binding pocket [chemical binding]; other site 754507000919 putative phosphate acyltransferase; Provisional; Region: PRK05331 754507000920 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 754507000921 hypothetical protein; Provisional; Region: PRK11193 754507000922 AAA domain; Region: AAA_26; pfam13500 754507000923 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 754507000924 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 754507000925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507000926 S-adenosylmethionine binding site [chemical binding]; other site 754507000927 Protein of unknown function (DUF452); Region: DUF452; cl01062 754507000928 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 754507000929 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 754507000930 substrate-cofactor binding pocket; other site 754507000931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507000932 catalytic residue [active] 754507000933 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 754507000934 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754507000935 inhibitor-cofactor binding pocket; inhibition site 754507000936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507000937 catalytic residue [active] 754507000938 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 754507000939 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 754507000940 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 754507000941 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754507000942 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 754507000943 substrate binding site [chemical binding]; other site 754507000944 nucleotide binding site [chemical binding]; other site 754507000945 Uncharacterized conserved protein [Function unknown]; Region: COG2966 754507000946 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 754507000947 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 754507000948 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 754507000949 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 754507000950 folate binding site [chemical binding]; other site 754507000951 NADP+ binding site [chemical binding]; other site 754507000952 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 754507000953 Domain of unknown function DUF21; Region: DUF21; pfam01595 754507000954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754507000955 Transporter associated domain; Region: CorC_HlyC; smart01091 754507000956 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 754507000957 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 754507000958 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 754507000959 active site 754507000960 DNA polymerase III subunit delta'; Validated; Region: PRK06871 754507000961 DNA polymerase III subunit delta'; Validated; Region: PRK08485 754507000962 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 754507000963 thymidylate kinase; Validated; Region: tmk; PRK00698 754507000964 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 754507000965 TMP-binding site; other site 754507000966 ATP-binding site [chemical binding]; other site 754507000967 conserved hypothetical protein, YceG family; Region: TIGR00247 754507000968 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 754507000969 dimerization interface [polypeptide binding]; other site 754507000970 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 754507000971 Nitrogen regulatory protein P-II; Region: P-II; smart00938 754507000972 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754507000973 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754507000974 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754507000975 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 754507000976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 754507000977 putative aldolase; Validated; Region: PRK08130 754507000978 intersubunit interface [polypeptide binding]; other site 754507000979 active site 754507000980 Zn2+ binding site [ion binding]; other site 754507000981 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 754507000982 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754507000983 Metal-binding active site; metal-binding site 754507000984 fructuronate transporter; Provisional; Region: PRK10034; cl15264 754507000985 GntP family permease; Region: GntP_permease; pfam02447 754507000986 Predicted peptidase [General function prediction only]; Region: COG4099 754507000987 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 754507000988 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 754507000989 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754507000990 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 754507000991 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 754507000992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507000993 active site 754507000994 motif I; other site 754507000995 motif II; other site 754507000996 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507000997 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 754507000998 MutS domain I; Region: MutS_I; pfam01624 754507000999 MutS domain II; Region: MutS_II; pfam05188 754507001000 MutS domain III; Region: MutS_III; pfam05192 754507001001 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 754507001002 Walker A/P-loop; other site 754507001003 ATP binding site [chemical binding]; other site 754507001004 Q-loop/lid; other site 754507001005 ABC transporter signature motif; other site 754507001006 Walker B; other site 754507001007 D-loop; other site 754507001008 H-loop/switch region; other site 754507001009 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 754507001010 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 754507001011 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 754507001012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507001013 S-adenosylmethionine binding site [chemical binding]; other site 754507001014 hypothetical protein; Provisional; Region: PRK11027 754507001015 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 754507001016 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 754507001017 catalytic residues [active] 754507001018 hinge region; other site 754507001019 alpha helical domain; other site 754507001020 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 754507001021 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 754507001022 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 754507001023 GTP binding site; other site 754507001024 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779 754507001025 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754507001026 active site 754507001027 phosphorylation site [posttranslational modification] 754507001028 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754507001029 dimerization domain swap beta strand [polypeptide binding]; other site 754507001030 regulatory protein interface [polypeptide binding]; other site 754507001031 active site 754507001032 regulatory phosphorylation site [posttranslational modification]; other site 754507001033 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754507001034 dimerization domain swap beta strand [polypeptide binding]; other site 754507001035 regulatory protein interface [polypeptide binding]; other site 754507001036 active site 754507001037 regulatory phosphorylation site [posttranslational modification]; other site 754507001038 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 754507001039 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 754507001040 putative substrate binding site [chemical binding]; other site 754507001041 putative ATP binding site [chemical binding]; other site 754507001042 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 754507001043 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 754507001044 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 754507001045 active site 754507001046 P-loop; other site 754507001047 phosphorylation site [posttranslational modification] 754507001048 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 754507001049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754507001050 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 754507001051 YCII-related domain; Region: YCII; cl00999 754507001052 Uncharacterized conserved protein [Function unknown]; Region: COG1359 754507001053 Uncharacterized conserved protein [Function unknown]; Region: COG1359 754507001054 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 754507001055 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 754507001056 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 754507001057 putative homodimer interface [polypeptide binding]; other site 754507001058 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 754507001059 heterodimer interface [polypeptide binding]; other site 754507001060 homodimer interface [polypeptide binding]; other site 754507001061 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 754507001062 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 754507001063 23S rRNA interface [nucleotide binding]; other site 754507001064 L7/L12 interface [polypeptide binding]; other site 754507001065 putative thiostrepton binding site; other site 754507001066 L25 interface [polypeptide binding]; other site 754507001067 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 754507001068 mRNA/rRNA interface [nucleotide binding]; other site 754507001069 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 754507001070 23S rRNA interface [nucleotide binding]; other site 754507001071 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 754507001072 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 754507001073 core dimer interface [polypeptide binding]; other site 754507001074 peripheral dimer interface [polypeptide binding]; other site 754507001075 L10 interface [polypeptide binding]; other site 754507001076 L11 interface [polypeptide binding]; other site 754507001077 putative EF-Tu interaction site [polypeptide binding]; other site 754507001078 putative EF-G interaction site [polypeptide binding]; other site 754507001079 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 754507001080 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 754507001081 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 754507001082 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 754507001083 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 754507001084 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 754507001085 RPB1 interaction site [polypeptide binding]; other site 754507001086 RPB11 interaction site [polypeptide binding]; other site 754507001087 RPB10 interaction site [polypeptide binding]; other site 754507001088 RPB3 interaction site [polypeptide binding]; other site 754507001089 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 754507001090 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 754507001091 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 754507001092 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 754507001093 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 754507001094 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 754507001095 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 754507001096 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 754507001097 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 754507001098 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 754507001099 DNA binding site [nucleotide binding] 754507001100 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 754507001101 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 754507001102 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 754507001103 23S rRNA interface [nucleotide binding]; other site 754507001104 putative translocon interaction site; other site 754507001105 signal recognition particle (SRP54) interaction site; other site 754507001106 L23 interface [polypeptide binding]; other site 754507001107 trigger factor interaction site; other site 754507001108 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 754507001109 23S rRNA interface [nucleotide binding]; other site 754507001110 5S rRNA interface [nucleotide binding]; other site 754507001111 putative antibiotic binding site [chemical binding]; other site 754507001112 L25 interface [polypeptide binding]; other site 754507001113 L27 interface [polypeptide binding]; other site 754507001114 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 754507001115 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 754507001116 G-X-X-G motif; other site 754507001117 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 754507001118 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 754507001119 protein-rRNA interface [nucleotide binding]; other site 754507001120 putative translocon binding site; other site 754507001121 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 754507001122 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 754507001123 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 754507001124 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 754507001125 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 754507001126 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 754507001127 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 754507001128 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 754507001129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754507001130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507001131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754507001132 dimerization interface [polypeptide binding]; other site 754507001133 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 754507001134 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 754507001135 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 754507001136 putative acyltransferase; Provisional; Region: PRK05790 754507001137 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 754507001138 dimer interface [polypeptide binding]; other site 754507001139 active site 754507001140 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 754507001141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754507001142 putative DNA binding site [nucleotide binding]; other site 754507001143 dimerization interface [polypeptide binding]; other site 754507001144 putative Zn2+ binding site [ion binding]; other site 754507001145 AsnC family; Region: AsnC_trans_reg; pfam01037 754507001146 Predicted membrane protein [Function unknown]; Region: COG1288 754507001147 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 754507001148 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 754507001149 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 754507001150 putative substrate binding site [chemical binding]; other site 754507001151 nucleotide binding site [chemical binding]; other site 754507001152 nucleotide binding site [chemical binding]; other site 754507001153 homodimer interface [polypeptide binding]; other site 754507001154 ornithine carbamoyltransferase; Provisional; Region: PRK01713 754507001155 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 754507001156 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 754507001157 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 754507001158 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 754507001159 putative ion selectivity filter; other site 754507001160 putative pore gating glutamate residue; other site 754507001161 putative H+/Cl- coupling transport residue; other site 754507001162 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 754507001163 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754507001164 FMN binding site [chemical binding]; other site 754507001165 active site 754507001166 catalytic residues [active] 754507001167 substrate binding site [chemical binding]; other site 754507001168 Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502 754507001169 motif 1; other site 754507001170 dimer interface [polypeptide binding]; other site 754507001171 active site 754507001172 motif 2; other site 754507001173 motif 3; other site 754507001174 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 754507001175 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 754507001176 putative DNA binding site [nucleotide binding]; other site 754507001177 putative Zn2+ binding site [ion binding]; other site 754507001178 AsnC family; Region: AsnC_trans_reg; pfam01037 754507001179 uridine phosphorylase; Provisional; Region: PRK11178 754507001180 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 754507001181 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 754507001182 Domain of unknown function DUF20; Region: UPF0118; pfam01594 754507001183 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 754507001184 ArsC family; Region: ArsC; pfam03960 754507001185 catalytic residues [active] 754507001186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 754507001187 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 754507001188 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 754507001189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507001190 FeS/SAM binding site; other site 754507001191 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 754507001192 Low molecular weight phosphatase family; Region: LMWPc; cd00115 754507001193 active site 754507001194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 754507001195 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 754507001196 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754507001197 Protein of unknown function (DUF541); Region: SIMPL; cl01077 754507001198 RNase E inhibitor protein; Provisional; Region: PRK11191 754507001199 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 754507001200 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 754507001201 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 754507001202 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 754507001203 TrkA-N domain; Region: TrkA_N; pfam02254 754507001204 TrkA-C domain; Region: TrkA_C; pfam02080 754507001205 TrkA-N domain; Region: TrkA_N; pfam02254 754507001206 TrkA-C domain; Region: TrkA_C; pfam02080 754507001207 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 754507001208 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 754507001209 putative active site [active] 754507001210 substrate binding site [chemical binding]; other site 754507001211 putative cosubstrate binding site; other site 754507001212 catalytic site [active] 754507001213 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 754507001214 substrate binding site [chemical binding]; other site 754507001215 16S rRNA methyltransferase B; Provisional; Region: PRK10901 754507001216 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 754507001217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507001218 S-adenosylmethionine binding site [chemical binding]; other site 754507001219 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 754507001220 active site 754507001221 catalytic residues [active] 754507001222 metal binding site [ion binding]; metal-binding site 754507001223 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 754507001224 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507001225 active site 754507001226 motif I; other site 754507001227 motif II; other site 754507001228 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 754507001229 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 754507001230 Walker A/P-loop; other site 754507001231 ATP binding site [chemical binding]; other site 754507001232 Q-loop/lid; other site 754507001233 ABC transporter signature motif; other site 754507001234 Walker B; other site 754507001235 D-loop; other site 754507001236 H-loop/switch region; other site 754507001237 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 754507001238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507001239 dimer interface [polypeptide binding]; other site 754507001240 conserved gate region; other site 754507001241 ABC-ATPase subunit interface; other site 754507001242 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 754507001243 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 754507001244 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 754507001245 substrate binding site [chemical binding]; other site 754507001246 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 754507001247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 754507001248 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 754507001249 GTP/Mg2+ binding site [chemical binding]; other site 754507001250 G5 box; other site 754507001251 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 754507001252 G1 box; other site 754507001253 G1 box; other site 754507001254 GTP/Mg2+ binding site [chemical binding]; other site 754507001255 Switch I region; other site 754507001256 Switch I region; other site 754507001257 G2 box; other site 754507001258 G2 box; other site 754507001259 G3 box; other site 754507001260 G3 box; other site 754507001261 Switch II region; other site 754507001262 Switch II region; other site 754507001263 G4 box; other site 754507001264 G5 box; other site 754507001265 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754507001266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507001267 Walker A motif; other site 754507001268 ATP binding site [chemical binding]; other site 754507001269 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754507001270 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754507001271 ATP binding site [chemical binding]; other site 754507001272 substrate binding site [chemical binding]; other site 754507001273 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 754507001274 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 754507001275 Ligand Binding Site [chemical binding]; other site 754507001276 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754507001277 helix-hairpin-helix signature motif; other site 754507001278 substrate binding pocket [chemical binding]; other site 754507001279 active site 754507001280 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 754507001281 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 754507001282 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 754507001283 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 754507001284 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 754507001285 RHS Repeat; Region: RHS_repeat; pfam05593 754507001286 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 754507001287 RHS Repeat; Region: RHS_repeat; pfam05593 754507001288 RHS Repeat; Region: RHS_repeat; pfam05593 754507001289 RHS Repeat; Region: RHS_repeat; pfam05593 754507001290 RHS Repeat; Region: RHS_repeat; pfam05593 754507001291 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 754507001292 RHS protein; Region: RHS; pfam03527 754507001293 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 754507001294 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 754507001295 ParB-like nuclease domain; Region: ParB; smart00470 754507001296 RepB plasmid partitioning protein; Region: RepB; pfam07506 754507001297 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 754507001298 ParB-like nuclease domain; Region: ParB; smart00470 754507001299 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 754507001300 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 754507001301 catalytic residues [active] 754507001302 catalytic nucleophile [active] 754507001303 Recombinase; Region: Recombinase; pfam07508 754507001304 TniQ; Region: TniQ; pfam06527 754507001305 Bacterial TniB protein; Region: TniB; pfam05621 754507001306 AAA domain; Region: AAA_22; pfam13401 754507001307 Helix-turn-helix domain; Region: HTH_28; pfam13518 754507001308 Winged helix-turn helix; Region: HTH_29; pfam13551 754507001309 Homeodomain-like domain; Region: HTH_32; pfam13565 754507001310 Integrase core domain; Region: rve; pfam00665 754507001311 Integrase core domain; Region: rve_3; cl15866 754507001312 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 754507001313 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 754507001314 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 754507001315 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 754507001316 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 754507001317 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 754507001318 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 754507001319 NodB motif; other site 754507001320 putative active site [active] 754507001321 putative catalytic site [active] 754507001322 Zn binding site [ion binding]; other site 754507001323 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 754507001324 Peptidase family M23; Region: Peptidase_M23; pfam01551 754507001325 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 754507001326 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 754507001327 active site 754507001328 substrate binding site [chemical binding]; other site 754507001329 metal binding site [ion binding]; metal-binding site 754507001330 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754507001331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754507001332 hypothetical protein; Validated; Region: PRK05445 754507001333 VacJ like lipoprotein; Region: VacJ; pfam04333 754507001334 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 754507001335 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 754507001336 substrate binding site [chemical binding]; other site 754507001337 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 754507001338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507001339 Walker A motif; other site 754507001340 ATP binding site [chemical binding]; other site 754507001341 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 754507001342 Walker B motif; other site 754507001343 arginine finger; other site 754507001344 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 754507001345 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 754507001346 active site 754507001347 HslU subunit interaction site [polypeptide binding]; other site 754507001348 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 754507001349 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 754507001350 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 754507001351 aromatic amino acid transport protein; Region: araaP; TIGR00837 754507001352 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 754507001353 dimer interface [polypeptide binding]; other site 754507001354 substrate binding site [chemical binding]; other site 754507001355 metal binding sites [ion binding]; metal-binding site 754507001356 Peptidase family M48; Region: Peptidase_M48; pfam01435 754507001357 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792 754507001358 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 754507001359 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 754507001360 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 754507001361 active site 754507001362 HIGH motif; other site 754507001363 dimer interface [polypeptide binding]; other site 754507001364 KMSKS motif; other site 754507001365 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 754507001366 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 754507001367 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 754507001368 P loop; other site 754507001369 GTP binding site [chemical binding]; other site 754507001370 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 754507001371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507001372 S-adenosylmethionine binding site [chemical binding]; other site 754507001373 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 754507001374 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 754507001375 active pocket/dimerization site; other site 754507001376 active site 754507001377 phosphorylation site [posttranslational modification] 754507001378 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 754507001379 active site 754507001380 phosphorylation site [posttranslational modification] 754507001381 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 754507001382 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 754507001383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507001384 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 754507001385 active site 754507001386 motif I; other site 754507001387 motif II; other site 754507001388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507001389 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 754507001390 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 754507001391 Nucleoside recognition; Region: Gate; pfam07670 754507001392 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 754507001393 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 754507001394 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 754507001395 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 754507001396 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 754507001397 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 754507001398 putative active site [active] 754507001399 putative metal binding site [ion binding]; other site 754507001400 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 754507001401 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 754507001402 DXD motif; other site 754507001403 PgaD-like protein; Region: PgaD; cl14676 754507001404 regulatory protein UhpC; Provisional; Region: PRK11663 754507001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507001406 putative substrate translocation pore; other site 754507001407 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 754507001408 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 754507001409 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 754507001410 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 754507001411 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 754507001412 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 754507001413 AAA domain; Region: AAA_14; pfam13173 754507001414 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 754507001415 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 754507001416 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 754507001417 ATP binding site [chemical binding]; other site 754507001418 Mg++ binding site [ion binding]; other site 754507001419 motif III; other site 754507001420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507001421 nucleotide binding region [chemical binding]; other site 754507001422 ATP-binding site [chemical binding]; other site 754507001423 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 754507001424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507001425 S-adenosylmethionine binding site [chemical binding]; other site 754507001426 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 754507001427 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754507001428 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754507001429 active site 754507001430 S-ribosylhomocysteinase; Provisional; Region: PRK02260 754507001431 Predicted membrane protein [Function unknown]; Region: COG1238 754507001432 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 754507001433 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 754507001434 active site 754507001435 substrate binding site [chemical binding]; other site 754507001436 trimer interface [polypeptide binding]; other site 754507001437 CoA binding site [chemical binding]; other site 754507001438 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 754507001439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507001440 active site 754507001441 motif I; other site 754507001442 motif II; other site 754507001443 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 754507001444 Part of AAA domain; Region: AAA_19; pfam13245 754507001445 Family description; Region: UvrD_C_2; pfam13538 754507001446 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 754507001447 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 754507001448 DNA polymerase I; Provisional; Region: PRK05755 754507001449 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 754507001450 active site 754507001451 metal binding site 1 [ion binding]; metal-binding site 754507001452 putative 5' ssDNA interaction site; other site 754507001453 metal binding site 3; metal-binding site 754507001454 metal binding site 2 [ion binding]; metal-binding site 754507001455 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 754507001456 putative DNA binding site [nucleotide binding]; other site 754507001457 putative metal binding site [ion binding]; other site 754507001458 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 754507001459 active site 754507001460 catalytic site [active] 754507001461 substrate binding site [chemical binding]; other site 754507001462 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 754507001463 active site 754507001464 DNA binding site [nucleotide binding] 754507001465 catalytic site [active] 754507001466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754507001467 Helix-turn-helix domain; Region: HTH_28; pfam13518 754507001468 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 754507001469 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 754507001470 active site 754507001471 metal binding site [ion binding]; metal-binding site 754507001472 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 754507001473 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 754507001474 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 754507001475 NADP binding site [chemical binding]; other site 754507001476 homopentamer interface [polypeptide binding]; other site 754507001477 substrate binding site [chemical binding]; other site 754507001478 active site 754507001479 Fic family protein [Function unknown]; Region: COG3177 754507001480 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 754507001481 Fic/DOC family; Region: Fic; pfam02661 754507001482 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754507001483 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754507001484 putative active site [active] 754507001485 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 754507001486 CHAP domain; Region: CHAP; pfam05257 754507001487 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 754507001488 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 754507001489 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 754507001490 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 754507001491 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 754507001492 4Fe-4S binding domain; Region: Fer4_5; pfam12801 754507001493 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754507001494 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 754507001495 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 754507001496 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 754507001497 [4Fe-4S] binding site [ion binding]; other site 754507001498 molybdopterin cofactor binding site; other site 754507001499 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 754507001500 molybdopterin cofactor binding site; other site 754507001501 NapD protein; Region: NapD; cl01163 754507001502 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 754507001503 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 754507001504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754507001505 dimerization interface [polypeptide binding]; other site 754507001506 Histidine kinase; Region: HisKA_3; pfam07730 754507001507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507001508 ATP binding site [chemical binding]; other site 754507001509 Mg2+ binding site [ion binding]; other site 754507001510 G-X-G motif; other site 754507001511 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 754507001512 FAD binding domain; Region: FAD_binding_4; pfam01565 754507001513 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 754507001514 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 754507001515 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 754507001516 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754507001517 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754507001518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754507001519 DNA binding residues [nucleotide binding] 754507001520 TfoX C-terminal domain; Region: TfoX_C; pfam04994 754507001521 elongation factor Tu; Reviewed; Region: PRK00049 754507001522 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754507001523 G1 box; other site 754507001524 GEF interaction site [polypeptide binding]; other site 754507001525 GTP/Mg2+ binding site [chemical binding]; other site 754507001526 Switch I region; other site 754507001527 G2 box; other site 754507001528 G3 box; other site 754507001529 Switch II region; other site 754507001530 G4 box; other site 754507001531 G5 box; other site 754507001532 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 754507001533 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754507001534 Antibiotic Binding Site [chemical binding]; other site 754507001535 elongation factor G; Reviewed; Region: PRK00007 754507001536 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 754507001537 G1 box; other site 754507001538 putative GEF interaction site [polypeptide binding]; other site 754507001539 GTP/Mg2+ binding site [chemical binding]; other site 754507001540 Switch I region; other site 754507001541 G2 box; other site 754507001542 G3 box; other site 754507001543 Switch II region; other site 754507001544 G4 box; other site 754507001545 G5 box; other site 754507001546 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 754507001547 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 754507001548 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 754507001549 30S ribosomal protein S7; Validated; Region: PRK05302 754507001550 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 754507001551 S17 interaction site [polypeptide binding]; other site 754507001552 S8 interaction site; other site 754507001553 16S rRNA interaction site [nucleotide binding]; other site 754507001554 streptomycin interaction site [chemical binding]; other site 754507001555 23S rRNA interaction site [nucleotide binding]; other site 754507001556 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 754507001557 ketol-acid reductoisomerase; Validated; Region: PRK05225 754507001558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 754507001559 Predicted permeases [General function prediction only]; Region: RarD; COG2962 754507001560 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 754507001561 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 754507001562 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 754507001563 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 754507001564 shikimate binding site; other site 754507001565 NAD(P) binding site [chemical binding]; other site 754507001566 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 754507001567 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754507001568 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 754507001569 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754507001570 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754507001571 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 754507001572 RmuC family; Region: RmuC; pfam02646 754507001573 hypothetical protein; Provisional; Region: PRK05208 754507001574 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 754507001575 active site residue [active] 754507001576 intramembrane serine protease GlpG; Provisional; Region: PRK10907 754507001577 Rhomboid family; Region: Rhomboid; pfam01694 754507001578 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 754507001579 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 754507001580 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754507001581 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 754507001582 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754507001583 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 754507001584 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 754507001585 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 754507001586 putative transporter; Validated; Region: PRK03818 754507001587 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 754507001588 TrkA-C domain; Region: TrkA_C; pfam02080 754507001589 TrkA-C domain; Region: TrkA_C; pfam02080 754507001590 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 754507001591 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 754507001592 putative nucleotide binding site [chemical binding]; other site 754507001593 uridine monophosphate binding site [chemical binding]; other site 754507001594 homohexameric interface [polypeptide binding]; other site 754507001595 ribosome recycling factor; Reviewed; Region: frr; PRK00083 754507001596 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 754507001597 hinge region; other site 754507001598 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 754507001599 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 754507001600 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 754507001601 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 754507001602 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 754507001603 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 754507001604 catalytic residue [active] 754507001605 putative FPP diphosphate binding site; other site 754507001606 putative FPP binding hydrophobic cleft; other site 754507001607 dimer interface [polypeptide binding]; other site 754507001608 putative IPP diphosphate binding site; other site 754507001609 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 754507001610 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 754507001611 zinc metallopeptidase RseP; Provisional; Region: PRK10779 754507001612 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 754507001613 active site 754507001614 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 754507001615 protein binding site [polypeptide binding]; other site 754507001616 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 754507001617 protein binding site [polypeptide binding]; other site 754507001618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 754507001619 putative substrate binding region [chemical binding]; other site 754507001620 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 754507001621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754507001622 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754507001623 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754507001624 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754507001625 Surface antigen; Region: Bac_surface_Ag; pfam01103 754507001626 periplasmic chaperone; Provisional; Region: PRK10780 754507001627 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 754507001628 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 754507001629 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 754507001630 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 754507001631 trimer interface [polypeptide binding]; other site 754507001632 active site 754507001633 UDP-GlcNAc binding site [chemical binding]; other site 754507001634 lipid binding site [chemical binding]; lipid-binding site 754507001635 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 754507001636 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 754507001637 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 754507001638 active site 754507001639 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 754507001640 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 754507001641 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 754507001642 RNA/DNA hybrid binding site [nucleotide binding]; other site 754507001643 active site 754507001644 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 754507001645 transmembrane helices; other site 754507001646 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754507001647 TrkA-C domain; Region: TrkA_C; pfam02080 754507001648 TrkA-C domain; Region: TrkA_C; pfam02080 754507001649 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 754507001650 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 754507001651 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 754507001652 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 754507001653 MPT binding site; other site 754507001654 trimer interface [polypeptide binding]; other site 754507001655 transaldolase-like protein; Provisional; Region: PTZ00411 754507001656 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 754507001657 active site 754507001658 dimer interface [polypeptide binding]; other site 754507001659 catalytic residue [active] 754507001660 transketolase; Reviewed; Region: PRK12753 754507001661 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 754507001662 TPP-binding site [chemical binding]; other site 754507001663 dimer interface [polypeptide binding]; other site 754507001664 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754507001665 PYR/PP interface [polypeptide binding]; other site 754507001666 dimer interface [polypeptide binding]; other site 754507001667 TPP binding site [chemical binding]; other site 754507001668 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754507001669 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 754507001670 homotrimer interaction site [polypeptide binding]; other site 754507001671 putative active site [active] 754507001672 recombination regulator RecX; Reviewed; Region: recX; PRK00117 754507001673 recombinase A; Provisional; Region: recA; PRK09354 754507001674 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 754507001675 hexamer interface [polypeptide binding]; other site 754507001676 Walker A motif; other site 754507001677 ATP binding site [chemical binding]; other site 754507001678 Walker B motif; other site 754507001679 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 754507001680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507001681 Walker A/P-loop; other site 754507001682 ATP binding site [chemical binding]; other site 754507001683 Q-loop/lid; other site 754507001684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507001685 ABC transporter signature motif; other site 754507001686 Walker B; other site 754507001687 D-loop; other site 754507001688 ABC transporter; Region: ABC_tran_2; pfam12848 754507001689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507001690 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 754507001691 hypothetical protein; Provisional; Region: PRK10695 754507001692 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 754507001693 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 754507001694 Homeodomain-like domain; Region: HTH_23; cl17451 754507001695 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 754507001696 intersubunit interface [polypeptide binding]; other site 754507001697 active site 754507001698 catalytic residue [active] 754507001699 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 754507001700 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 754507001701 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754507001702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754507001703 TPR motif; other site 754507001704 binding surface 754507001705 Uncharacterized conserved protein [Function unknown]; Region: COG1434 754507001706 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754507001707 putative active site [active] 754507001708 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 754507001709 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 754507001710 Substrate binding site; other site 754507001711 Mg++ binding site; other site 754507001712 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 754507001713 active site 754507001714 substrate binding site [chemical binding]; other site 754507001715 CoA binding site [chemical binding]; other site 754507001716 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 754507001717 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 754507001718 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 754507001719 putative active site [active] 754507001720 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 754507001721 Patatin-like phospholipase; Region: Patatin; pfam01734 754507001722 active site 754507001723 nucleophile elbow; other site 754507001724 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 754507001725 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 754507001726 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 754507001727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754507001728 substrate binding pocket [chemical binding]; other site 754507001729 membrane-bound complex binding site; other site 754507001730 hinge residues; other site 754507001731 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754507001732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507001733 dimer interface [polypeptide binding]; other site 754507001734 conserved gate region; other site 754507001735 putative PBP binding loops; other site 754507001736 ABC-ATPase subunit interface; other site 754507001737 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754507001738 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 754507001739 Walker A/P-loop; other site 754507001740 ATP binding site [chemical binding]; other site 754507001741 Q-loop/lid; other site 754507001742 ABC transporter signature motif; other site 754507001743 Walker B; other site 754507001744 D-loop; other site 754507001745 H-loop/switch region; other site 754507001746 DsrH like protein; Region: DsrH; cl17347 754507001747 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 754507001748 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 754507001749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 754507001750 YheO-like PAS domain; Region: PAS_6; pfam08348 754507001751 HTH domain; Region: HTH_22; pfam13309 754507001752 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 754507001753 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 754507001754 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 754507001755 hypothetical protein; Provisional; Region: PRK02119 754507001756 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 754507001757 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 754507001758 catalytic triad [active] 754507001759 dimer interface [polypeptide binding]; other site 754507001760 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 754507001761 GSH binding site [chemical binding]; other site 754507001762 catalytic residues [active] 754507001763 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 754507001764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507001765 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 754507001766 dimerization interface [polypeptide binding]; other site 754507001767 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 754507001768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754507001769 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754507001770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754507001771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507001772 Walker A/P-loop; other site 754507001773 ATP binding site [chemical binding]; other site 754507001774 Q-loop/lid; other site 754507001775 ABC transporter signature motif; other site 754507001776 Walker B; other site 754507001777 D-loop; other site 754507001778 H-loop/switch region; other site 754507001779 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 754507001780 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754507001781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507001782 Walker A/P-loop; other site 754507001783 ATP binding site [chemical binding]; other site 754507001784 Q-loop/lid; other site 754507001785 ABC transporter signature motif; other site 754507001786 Walker B; other site 754507001787 D-loop; other site 754507001788 H-loop/switch region; other site 754507001789 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 754507001790 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 754507001791 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 754507001792 active site residue [active] 754507001793 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 754507001794 SecA binding site; other site 754507001795 Preprotein binding site; other site 754507001796 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 754507001797 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 754507001798 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 754507001799 serine acetyltransferase; Provisional; Region: cysE; PRK11132 754507001800 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 754507001801 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 754507001802 trimer interface [polypeptide binding]; other site 754507001803 active site 754507001804 substrate binding site [chemical binding]; other site 754507001805 CoA binding site [chemical binding]; other site 754507001806 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 754507001807 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 754507001808 putative active site [active] 754507001809 Protein of unknown function (DUF904); Region: DUF904; pfam06005 754507001810 FMN-binding protein MioC; Provisional; Region: PRK09004 754507001811 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 754507001812 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 754507001813 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 754507001814 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 754507001815 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 754507001816 NADP binding site [chemical binding]; other site 754507001817 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 754507001818 Predicted transcriptional regulators [Transcription]; Region: COG1733 754507001819 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 754507001820 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 754507001821 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 754507001822 F0F1 ATP synthase subunit I; Validated; Region: PRK06099 754507001823 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 754507001824 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 754507001825 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 754507001826 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 754507001827 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 754507001828 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 754507001829 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 754507001830 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 754507001831 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754507001832 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 754507001833 beta subunit interaction interface [polypeptide binding]; other site 754507001834 Walker A motif; other site 754507001835 ATP binding site [chemical binding]; other site 754507001836 Walker B motif; other site 754507001837 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754507001838 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 754507001839 core domain interface [polypeptide binding]; other site 754507001840 delta subunit interface [polypeptide binding]; other site 754507001841 epsilon subunit interface [polypeptide binding]; other site 754507001842 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 754507001843 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 754507001844 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 754507001845 alpha subunit interaction interface [polypeptide binding]; other site 754507001846 Walker A motif; other site 754507001847 ATP binding site [chemical binding]; other site 754507001848 Walker B motif; other site 754507001849 inhibitor binding site; inhibition site 754507001850 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 754507001851 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 754507001852 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 754507001853 gamma subunit interface [polypeptide binding]; other site 754507001854 epsilon subunit interface [polypeptide binding]; other site 754507001855 LBP interface [polypeptide binding]; other site 754507001856 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 754507001857 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 754507001858 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 754507001859 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 754507001860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507001861 ATP binding site [chemical binding]; other site 754507001862 putative Mg++ binding site [ion binding]; other site 754507001863 Virulence protein [General function prediction only]; Region: COG3943 754507001864 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 754507001865 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 754507001866 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 754507001867 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 754507001868 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 754507001869 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 754507001870 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 754507001871 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 754507001872 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 754507001873 active pocket/dimerization site; other site 754507001874 active site 754507001875 phosphorylation site [posttranslational modification] 754507001876 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 754507001877 active site 754507001878 phosphorylation site [posttranslational modification] 754507001879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507001880 putative transporter; Provisional; Region: PRK10504 754507001881 putative substrate translocation pore; other site 754507001882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507001883 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 754507001884 putative dimerization interface [polypeptide binding]; other site 754507001885 Transcriptional regulators [Transcription]; Region: PurR; COG1609 754507001886 putative ligand binding site [chemical binding]; other site 754507001887 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 754507001888 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754507001889 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 754507001890 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 754507001891 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754507001892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507001893 homodimer interface [polypeptide binding]; other site 754507001894 catalytic residue [active] 754507001895 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 754507001896 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507001897 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507001898 TM-ABC transporter signature motif; other site 754507001899 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 754507001900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507001901 Walker A/P-loop; other site 754507001902 ATP binding site [chemical binding]; other site 754507001903 Q-loop/lid; other site 754507001904 ABC transporter signature motif; other site 754507001905 Walker B; other site 754507001906 D-loop; other site 754507001907 H-loop/switch region; other site 754507001908 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754507001909 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 754507001910 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 754507001911 putative ligand binding site [chemical binding]; other site 754507001912 xylose isomerase; Provisional; Region: PRK05474 754507001913 xylose isomerase; Region: xylose_isom_A; TIGR02630 754507001914 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 754507001915 N- and C-terminal domain interface [polypeptide binding]; other site 754507001916 D-xylulose kinase; Region: XylB; TIGR01312 754507001917 active site 754507001918 MgATP binding site [chemical binding]; other site 754507001919 catalytic site [active] 754507001920 metal binding site [ion binding]; metal-binding site 754507001921 xylulose binding site [chemical binding]; other site 754507001922 putative homodimer interface [polypeptide binding]; other site 754507001923 putative transposase OrfB; Reviewed; Region: PHA02517 754507001924 HTH-like domain; Region: HTH_21; pfam13276 754507001925 Integrase core domain; Region: rve; pfam00665 754507001926 Integrase core domain; Region: rve_2; pfam13333 754507001927 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 754507001928 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 754507001929 domain interface [polypeptide binding]; other site 754507001930 putative active site [active] 754507001931 catalytic site [active] 754507001932 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 754507001933 domain interface [polypeptide binding]; other site 754507001934 putative active site [active] 754507001935 catalytic site [active] 754507001936 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 754507001937 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 754507001938 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 754507001939 ferredoxin; Validated; Region: PRK07118 754507001940 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 754507001941 B1 nucleotide binding pocket [chemical binding]; other site 754507001942 B2 nucleotide binding pocket [chemical binding]; other site 754507001943 CAS motifs; other site 754507001944 active site 754507001945 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 754507001946 Phosphoglycerate kinase; Region: PGK; pfam00162 754507001947 substrate binding site [chemical binding]; other site 754507001948 hinge regions; other site 754507001949 ADP binding site [chemical binding]; other site 754507001950 catalytic site [active] 754507001951 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 754507001952 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 754507001953 active site 754507001954 intersubunit interface [polypeptide binding]; other site 754507001955 zinc binding site [ion binding]; other site 754507001956 Na+ binding site [ion binding]; other site 754507001957 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 754507001958 O-Antigen ligase; Region: Wzy_C; pfam04932 754507001959 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 754507001960 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 754507001961 Serine hydrolase; Region: Ser_hydrolase; cl17834 754507001962 putative hydrolase; Provisional; Region: PRK10976 754507001963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507001964 active site 754507001965 motif I; other site 754507001966 motif II; other site 754507001967 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754507001968 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754507001969 TPP binding site [chemical binding]; other site 754507001970 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754507001971 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 754507001972 catalytic residue [active] 754507001973 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 754507001974 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 754507001975 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754507001976 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754507001977 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 754507001978 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 754507001979 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 754507001980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507001981 Walker A/P-loop; other site 754507001982 ATP binding site [chemical binding]; other site 754507001983 Q-loop/lid; other site 754507001984 ABC transporter signature motif; other site 754507001985 Walker B; other site 754507001986 D-loop; other site 754507001987 H-loop/switch region; other site 754507001988 phosphoglycolate phosphatase; Provisional; Region: PRK13222 754507001989 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 754507001990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507001991 motif II; other site 754507001992 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 754507001993 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 754507001994 substrate binding site [chemical binding]; other site 754507001995 hexamer interface [polypeptide binding]; other site 754507001996 metal binding site [ion binding]; metal-binding site 754507001997 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 754507001998 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 754507001999 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 754507002000 substrate binding site; other site 754507002001 dimer interface; other site 754507002002 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 754507002003 homotrimer interaction site [polypeptide binding]; other site 754507002004 zinc binding site [ion binding]; other site 754507002005 CDP-binding sites; other site 754507002006 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 754507002007 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 754507002008 Permutation of conserved domain; other site 754507002009 active site 754507002010 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 754507002011 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 754507002012 Predicted membrane protein [Function unknown]; Region: COG1238 754507002013 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 754507002014 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754507002015 Peptidase family M23; Region: Peptidase_M23; pfam01551 754507002016 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754507002017 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 754507002018 putative metal binding site; other site 754507002019 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 754507002020 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 754507002021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754507002022 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 754507002023 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 754507002024 active site 754507002025 (T/H)XGH motif; other site 754507002026 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 754507002027 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 754507002028 active site 754507002029 ATP binding site [chemical binding]; other site 754507002030 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754507002031 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754507002032 putative active site [active] 754507002033 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 754507002034 Cupin; Region: Cupin_6; pfam12852 754507002035 Helix-turn-helix domain; Region: HTH_18; pfam12833 754507002036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754507002037 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 754507002038 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 754507002039 Walker A/P-loop; other site 754507002040 ATP binding site [chemical binding]; other site 754507002041 Q-loop/lid; other site 754507002042 ABC transporter signature motif; other site 754507002043 Walker B; other site 754507002044 D-loop; other site 754507002045 H-loop/switch region; other site 754507002046 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 754507002047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 754507002048 putative acyl-acceptor binding pocket; other site 754507002049 LexA repressor; Validated; Region: PRK00215 754507002050 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 754507002051 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 754507002052 Catalytic site [active] 754507002053 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 754507002054 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754507002055 dimer interface [polypeptide binding]; other site 754507002056 ssDNA binding site [nucleotide binding]; other site 754507002057 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754507002058 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 754507002059 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 754507002060 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 754507002061 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 754507002062 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 754507002063 DNA protecting protein DprA; Region: dprA; TIGR00732 754507002064 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 754507002065 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 754507002066 active site 754507002067 catalytic site [active] 754507002068 metal binding site [ion binding]; metal-binding site 754507002069 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 754507002070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507002071 putative substrate translocation pore; other site 754507002072 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 754507002073 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 754507002074 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 754507002075 exoribonuclease R; Provisional; Region: PRK11642 754507002076 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 754507002077 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 754507002078 RNB domain; Region: RNB; pfam00773 754507002079 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 754507002080 RNA binding site [nucleotide binding]; other site 754507002081 rod shape-determining protein MreB; Provisional; Region: PRK13927 754507002082 MreB and similar proteins; Region: MreB_like; cd10225 754507002083 nucleotide binding site [chemical binding]; other site 754507002084 Mg binding site [ion binding]; other site 754507002085 putative protofilament interaction site [polypeptide binding]; other site 754507002086 RodZ interaction site [polypeptide binding]; other site 754507002087 rod shape-determining protein MreC; Region: mreC; TIGR00219 754507002088 rod shape-determining protein MreC; Region: MreC; pfam04085 754507002089 rod shape-determining protein MreD; Region: MreD; cl01087 754507002090 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 754507002091 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 754507002092 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 754507002093 RimM N-terminal domain; Region: RimM; pfam01782 754507002094 PRC-barrel domain; Region: PRC; pfam05239 754507002095 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 754507002096 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 754507002097 proline aminopeptidase P II; Provisional; Region: PRK10879 754507002098 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 754507002099 active site 754507002100 hypothetical protein; Reviewed; Region: PRK01736 754507002101 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 754507002102 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 754507002103 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 754507002104 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 754507002105 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 754507002106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507002107 RNA binding surface [nucleotide binding]; other site 754507002108 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754507002109 active site 754507002110 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 754507002111 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 754507002112 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 754507002113 Sulfatase; Region: Sulfatase; cl17466 754507002114 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 754507002115 dimer interface [polypeptide binding]; other site 754507002116 FMN binding site [chemical binding]; other site 754507002117 hypothetical protein; Validated; Region: PRK05090 754507002118 YGGT family; Region: YGGT; pfam02325 754507002119 Predicted integral membrane protein [Function unknown]; Region: COG0762 754507002120 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 754507002121 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 754507002122 Cl binding site [ion binding]; other site 754507002123 oligomer interface [polypeptide binding]; other site 754507002124 Methyltransferase domain; Region: Methyltransf_31; pfam13847 754507002125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507002126 S-adenosylmethionine binding site [chemical binding]; other site 754507002127 multidrug efflux protein; Reviewed; Region: PRK09579 754507002128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754507002129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754507002130 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754507002131 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754507002132 HlyD family secretion protein; Region: HlyD_3; pfam13437 754507002133 Sporulation related domain; Region: SPOR; pfam05036 754507002134 primosome assembly protein PriA; Validated; Region: PRK05580 754507002135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507002136 ATP binding site [chemical binding]; other site 754507002137 putative Mg++ binding site [ion binding]; other site 754507002138 helicase superfamily c-terminal domain; Region: HELICc; smart00490 754507002139 nucleotide binding region [chemical binding]; other site 754507002140 ATP-binding site [chemical binding]; other site 754507002141 hypothetical protein; Provisional; Region: PRK11346 754507002142 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 754507002143 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754507002144 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 754507002145 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754507002146 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 754507002147 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754507002148 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754507002149 putative active site [active] 754507002150 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754507002151 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 754507002152 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 754507002153 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 754507002154 DNA binding site [nucleotide binding] 754507002155 catalytic residue [active] 754507002156 H2TH interface [polypeptide binding]; other site 754507002157 putative catalytic residues [active] 754507002158 turnover-facilitating residue; other site 754507002159 intercalation triad [nucleotide binding]; other site 754507002160 8OG recognition residue [nucleotide binding]; other site 754507002161 putative reading head residues; other site 754507002162 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 754507002163 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 754507002164 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 754507002165 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 754507002166 hypothetical protein; Reviewed; Region: PRK00024 754507002167 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 754507002168 MPN+ (JAMM) motif; other site 754507002169 Zinc-binding site [ion binding]; other site 754507002170 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 754507002171 Flavoprotein; Region: Flavoprotein; pfam02441 754507002172 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 754507002173 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754507002174 trimer interface [polypeptide binding]; other site 754507002175 active site 754507002176 division inhibitor protein; Provisional; Region: slmA; PRK09480 754507002177 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754507002178 hypothetical protein; Provisional; Region: PRK04966 754507002179 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 754507002180 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754507002181 ligand binding site [chemical binding]; other site 754507002182 flexible hinge region; other site 754507002183 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754507002184 putative switch regulator; other site 754507002185 non-specific DNA interactions [nucleotide binding]; other site 754507002186 DNA binding site [nucleotide binding] 754507002187 sequence specific DNA binding site [nucleotide binding]; other site 754507002188 putative cAMP binding site [chemical binding]; other site 754507002189 glutathione reductase; Validated; Region: PRK06116 754507002190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754507002191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754507002192 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754507002193 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 754507002194 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 754507002195 Transglycosylase; Region: Transgly; pfam00912 754507002196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754507002197 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 754507002198 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 754507002199 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 754507002200 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 754507002201 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 754507002202 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754507002203 shikimate kinase; Reviewed; Region: aroK; PRK00131 754507002204 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 754507002205 ADP binding site [chemical binding]; other site 754507002206 magnesium binding site [ion binding]; other site 754507002207 putative shikimate binding site; other site 754507002208 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 754507002209 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 754507002210 active site 754507002211 dimer interface [polypeptide binding]; other site 754507002212 metal binding site [ion binding]; metal-binding site 754507002213 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 754507002214 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 754507002215 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 754507002216 dimer interface [polypeptide binding]; other site 754507002217 ssDNA binding site [nucleotide binding]; other site 754507002218 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754507002219 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 754507002220 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754507002221 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 754507002222 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 754507002223 putative transposase OrfB; Reviewed; Region: PHA02517 754507002224 HTH-like domain; Region: HTH_21; pfam13276 754507002225 Integrase core domain; Region: rve; pfam00665 754507002226 Integrase core domain; Region: rve_2; pfam13333 754507002227 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 754507002228 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 754507002229 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 754507002230 homodimer interface [polypeptide binding]; other site 754507002231 NADP binding site [chemical binding]; other site 754507002232 substrate binding site [chemical binding]; other site 754507002233 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 754507002234 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 754507002235 ring oligomerisation interface [polypeptide binding]; other site 754507002236 ATP/Mg binding site [chemical binding]; other site 754507002237 stacking interactions; other site 754507002238 hinge regions; other site 754507002239 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 754507002240 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 754507002241 tetramer interface [polypeptide binding]; other site 754507002242 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 754507002243 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 754507002244 putative active site [active] 754507002245 HTH-like domain; Region: HTH_21; pfam13276 754507002246 Integrase core domain; Region: rve; pfam00665 754507002247 Integrase core domain; Region: rve_2; pfam13333 754507002248 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 754507002249 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 754507002250 Cation transport protein; Region: TrkH; cl17365 754507002251 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 754507002252 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 754507002253 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 754507002254 CPxP motif; other site 754507002255 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754507002256 non-specific DNA binding site [nucleotide binding]; other site 754507002257 salt bridge; other site 754507002258 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 754507002259 sequence-specific DNA binding site [nucleotide binding]; other site 754507002260 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 754507002261 active site 754507002262 (T/H)XGH motif; other site 754507002263 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 754507002264 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754507002265 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 754507002266 active site 754507002267 metal binding site [ion binding]; metal-binding site 754507002268 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 754507002269 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 754507002270 aromatic amino acid transport protein; Region: araaP; TIGR00837 754507002271 Transposase IS200 like; Region: Y1_Tnp; pfam01797 754507002272 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 754507002273 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 754507002274 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 754507002275 alphaNTD homodimer interface [polypeptide binding]; other site 754507002276 alphaNTD - beta interaction site [polypeptide binding]; other site 754507002277 alphaNTD - beta' interaction site [polypeptide binding]; other site 754507002278 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 754507002279 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 754507002280 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 754507002281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507002282 RNA binding surface [nucleotide binding]; other site 754507002283 30S ribosomal protein S11; Validated; Region: PRK05309 754507002284 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 754507002285 30S ribosomal protein S13; Region: bact_S13; TIGR03631 754507002286 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 754507002287 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 754507002288 SecY translocase; Region: SecY; pfam00344 754507002289 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 754507002290 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 754507002291 23S rRNA binding site [nucleotide binding]; other site 754507002292 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 754507002293 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 754507002294 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 754507002295 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 754507002296 5S rRNA interface [nucleotide binding]; other site 754507002297 L27 interface [polypeptide binding]; other site 754507002298 23S rRNA interface [nucleotide binding]; other site 754507002299 L5 interface [polypeptide binding]; other site 754507002300 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 754507002301 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754507002302 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 754507002303 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 754507002304 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 754507002305 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 754507002306 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 754507002307 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 754507002308 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 754507002309 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 754507002310 RNA binding site [nucleotide binding]; other site 754507002311 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 754507002312 Transposase IS200 like; Region: Y1_Tnp; pfam01797 754507002313 CTP synthetase; Validated; Region: pyrG; PRK05380 754507002314 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 754507002315 Catalytic site [active] 754507002316 active site 754507002317 UTP binding site [chemical binding]; other site 754507002318 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 754507002319 active site 754507002320 putative oxyanion hole; other site 754507002321 catalytic triad [active] 754507002322 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 754507002323 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 754507002324 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 754507002325 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 754507002326 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 754507002327 DNA utilization protein GntX; Provisional; Region: PRK11595 754507002328 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507002329 active site 754507002330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507002331 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 754507002332 active site 754507002333 motif I; other site 754507002334 motif II; other site 754507002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507002336 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 754507002337 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 754507002338 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 754507002339 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 754507002340 Clp amino terminal domain; Region: Clp_N; pfam02861 754507002341 Clp amino terminal domain; Region: Clp_N; pfam02861 754507002342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507002343 Walker A motif; other site 754507002344 ATP binding site [chemical binding]; other site 754507002345 Walker B motif; other site 754507002346 arginine finger; other site 754507002347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507002348 Walker A motif; other site 754507002349 ATP binding site [chemical binding]; other site 754507002350 Walker B motif; other site 754507002351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 754507002352 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 754507002353 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 754507002354 dimerization interface [polypeptide binding]; other site 754507002355 putative ATP binding site [chemical binding]; other site 754507002356 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 754507002357 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 754507002358 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754507002359 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 754507002360 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 754507002361 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 754507002362 active site 754507002363 Int/Topo IB signature motif; other site 754507002364 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 754507002365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507002366 motif II; other site 754507002367 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 754507002368 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 754507002369 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754507002370 putative acyl-acceptor binding pocket; other site 754507002371 Phosphopantetheine attachment site; Region: PP-binding; cl09936 754507002372 acyl carrier protein; Provisional; Region: PRK05350 754507002373 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 754507002374 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754507002375 AMP binding site [chemical binding]; other site 754507002376 active site 754507002377 acyl-activating enzyme (AAE) consensus motif; other site 754507002378 CoA binding site [chemical binding]; other site 754507002379 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 754507002380 active site 2 [active] 754507002381 active site 1 [active] 754507002382 Predicted membrane protein [Function unknown]; Region: COG4648 754507002383 AMP-binding enzyme; Region: AMP-binding; pfam00501 754507002384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754507002385 active site 754507002386 AMP binding site [chemical binding]; other site 754507002387 acyl-activating enzyme (AAE) consensus motif; other site 754507002388 CoA binding site [chemical binding]; other site 754507002389 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754507002390 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 754507002391 Ligand binding site; other site 754507002392 Putative Catalytic site; other site 754507002393 DXD motif; other site 754507002394 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 754507002395 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754507002396 putative acyl-acceptor binding pocket; other site 754507002397 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 754507002398 active site 754507002399 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 754507002400 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 754507002401 Predicted exporter [General function prediction only]; Region: COG4258 754507002402 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 754507002403 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754507002404 dimer interface [polypeptide binding]; other site 754507002405 active site 754507002406 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 754507002407 putative active site 1 [active] 754507002408 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 754507002409 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 754507002410 NAD(P) binding site [chemical binding]; other site 754507002411 homotetramer interface [polypeptide binding]; other site 754507002412 homodimer interface [polypeptide binding]; other site 754507002413 active site 754507002414 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 754507002415 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754507002416 dimer interface [polypeptide binding]; other site 754507002417 active site 754507002418 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 754507002419 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 754507002420 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 754507002421 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 754507002422 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 754507002423 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 754507002424 aspartate racemase; Region: asp_race; TIGR00035 754507002425 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 754507002426 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 754507002427 putative active site [active] 754507002428 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 754507002429 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 754507002430 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 754507002431 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 754507002432 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754507002433 active site 754507002434 Predicted membrane protein [Function unknown]; Region: COG1297 754507002435 putative oligopeptide transporter, OPT family; Region: TIGR00733 754507002436 Predicted membrane protein [Function unknown]; Region: COG3059 754507002437 Cupin; Region: Cupin_6; pfam12852 754507002438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 754507002439 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 754507002440 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 754507002441 ADP-ribose binding site [chemical binding]; other site 754507002442 dimer interface [polypeptide binding]; other site 754507002443 active site 754507002444 nudix motif; other site 754507002445 metal binding site [ion binding]; metal-binding site 754507002446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 754507002447 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754507002448 motif II; other site 754507002449 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507002450 RNA binding surface [nucleotide binding]; other site 754507002451 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 754507002452 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 754507002453 dimerization interface [polypeptide binding]; other site 754507002454 domain crossover interface; other site 754507002455 redox-dependent activation switch; other site 754507002456 twin arginine translocase protein A; Provisional; Region: tatA; PRK01833 754507002457 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 754507002458 sec-independent translocase; Provisional; Region: PRK01770 754507002459 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 754507002460 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 754507002461 dimer interface [polypeptide binding]; other site 754507002462 allosteric magnesium binding site [ion binding]; other site 754507002463 active site 754507002464 aspartate-rich active site metal binding site; other site 754507002465 Schiff base residues; other site 754507002466 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 754507002467 DALR anticodon binding domain; Region: DALR_1; pfam05746 754507002468 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 754507002469 active site 754507002470 NTP binding site [chemical binding]; other site 754507002471 metal binding triad [ion binding]; metal-binding site 754507002472 antibiotic binding site [chemical binding]; other site 754507002473 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 754507002474 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 754507002475 dimer interface [polypeptide binding]; other site 754507002476 motif 1; other site 754507002477 active site 754507002478 motif 2; other site 754507002479 motif 3; other site 754507002480 ferredoxin-type protein NapF; Region: napF; TIGR00402 754507002481 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 754507002482 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 754507002483 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 754507002484 4Fe-4S binding domain; Region: Fer4; cl02805 754507002485 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 754507002486 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 754507002487 putative [Fe4-S4] binding site [ion binding]; other site 754507002488 putative molybdopterin cofactor binding site [chemical binding]; other site 754507002489 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 754507002490 putative molybdopterin cofactor binding site; other site 754507002491 Fic/DOC family; Region: Fic; cl00960 754507002492 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 754507002493 Fic/DOC family; Region: Fic; pfam02661 754507002494 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 754507002495 FIC domain binding interface [polypeptide binding]; other site 754507002496 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 754507002497 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 754507002498 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 754507002499 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 754507002500 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 754507002501 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 754507002502 Domain of unknown function DUF21; Region: DUF21; pfam01595 754507002503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754507002504 Transporter associated domain; Region: CorC_HlyC; smart01091 754507002505 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 754507002506 signal recognition particle protein; Provisional; Region: PRK10867 754507002507 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 754507002508 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 754507002509 P loop; other site 754507002510 GTP binding site [chemical binding]; other site 754507002511 Signal peptide binding domain; Region: SRP_SPB; pfam02978 754507002512 S-formylglutathione hydrolase; Region: PLN02442 754507002513 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 754507002514 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 754507002515 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 754507002516 substrate binding site [chemical binding]; other site 754507002517 catalytic Zn binding site [ion binding]; other site 754507002518 NAD binding site [chemical binding]; other site 754507002519 structural Zn binding site [ion binding]; other site 754507002520 dimer interface [polypeptide binding]; other site 754507002521 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 754507002522 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 754507002523 DNA binding residues [nucleotide binding] 754507002524 putative dimer interface [polypeptide binding]; other site 754507002525 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 754507002526 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 754507002527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754507002528 NAD(P) binding site [chemical binding]; other site 754507002529 active site 754507002530 adenylosuccinate lyase; Provisional; Region: PRK09285 754507002531 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 754507002532 tetramer interface [polypeptide binding]; other site 754507002533 active site 754507002534 putative lysogenization regulator; Reviewed; Region: PRK00218 754507002535 Protein of unknown function (DUF461); Region: DUF461; cl01071 754507002536 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 754507002537 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507002538 active site 754507002539 SurA N-terminal domain; Region: SurA_N; pfam09312 754507002540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 754507002541 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 754507002542 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 754507002543 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 754507002544 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 754507002545 active site 754507002546 metal binding site [ion binding]; metal-binding site 754507002547 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 754507002548 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 754507002549 active site 754507002550 NTP binding site [chemical binding]; other site 754507002551 metal binding triad [ion binding]; metal-binding site 754507002552 antibiotic binding site [chemical binding]; other site 754507002553 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 754507002554 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 754507002555 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 754507002556 HIGH motif; other site 754507002557 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 754507002558 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754507002559 active site 754507002560 KMSKS motif; other site 754507002561 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 754507002562 tRNA binding surface [nucleotide binding]; other site 754507002563 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 754507002564 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 754507002565 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 754507002566 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 754507002567 active site 754507002568 8-oxo-dGMP binding site [chemical binding]; other site 754507002569 nudix motif; other site 754507002570 metal binding site [ion binding]; metal-binding site 754507002571 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 754507002572 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 754507002573 SEC-C motif; Region: SEC-C; pfam02810 754507002574 Protein of unknown function (DUF2547); Region: DUF2547; pfam10818 754507002575 Protein of unknown function (DUF721); Region: DUF721; cl02324 754507002576 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 754507002577 DNA binding residues [nucleotide binding] 754507002578 putative transposase OrfB; Reviewed; Region: PHA02517 754507002579 HTH-like domain; Region: HTH_21; pfam13276 754507002580 Integrase core domain; Region: rve; pfam00665 754507002581 Integrase core domain; Region: rve_2; pfam13333 754507002582 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 754507002583 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 754507002584 HD domain; Region: HD_4; pfam13328 754507002585 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 754507002586 synthetase active site [active] 754507002587 NTP binding site [chemical binding]; other site 754507002588 metal binding site [ion binding]; metal-binding site 754507002589 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 754507002590 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 754507002591 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 754507002592 TRAM domain; Region: TRAM; pfam01938 754507002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507002594 S-adenosylmethionine binding site [chemical binding]; other site 754507002595 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 754507002596 Recombination protein O N terminal; Region: RecO_N; pfam11967 754507002597 Recombination protein O C terminal; Region: RecO_C; pfam02565 754507002598 elongation factor Ts; Provisional; Region: tsf; PRK09377 754507002599 UBA/TS-N domain; Region: UBA; pfam00627 754507002600 Elongation factor TS; Region: EF_TS; pfam00889 754507002601 Elongation factor TS; Region: EF_TS; pfam00889 754507002602 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 754507002603 rRNA interaction site [nucleotide binding]; other site 754507002604 S8 interaction site; other site 754507002605 putative laminin-1 binding site; other site 754507002606 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 754507002607 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 754507002608 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 754507002609 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 754507002610 hypothetical protein; Provisional; Region: PRK11820 754507002611 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 754507002612 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 754507002613 ribonuclease PH; Reviewed; Region: rph; PRK00173 754507002614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 754507002615 hexamer interface [polypeptide binding]; other site 754507002616 active site 754507002617 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507002618 active site 754507002619 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 754507002620 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 754507002621 putative metal binding site [ion binding]; other site 754507002622 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754507002623 HSP70 interaction site [polypeptide binding]; other site 754507002624 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 754507002625 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 754507002626 FMN binding site [chemical binding]; other site 754507002627 active site 754507002628 catalytic residues [active] 754507002629 substrate binding site [chemical binding]; other site 754507002630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754507002631 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754507002632 Walker A/P-loop; other site 754507002633 ATP binding site [chemical binding]; other site 754507002634 Q-loop/lid; other site 754507002635 ABC transporter signature motif; other site 754507002636 Walker B; other site 754507002637 D-loop; other site 754507002638 H-loop/switch region; other site 754507002639 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754507002640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507002641 dimer interface [polypeptide binding]; other site 754507002642 conserved gate region; other site 754507002643 putative PBP binding loops; other site 754507002644 ABC-ATPase subunit interface; other site 754507002645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507002646 dimer interface [polypeptide binding]; other site 754507002647 conserved gate region; other site 754507002648 putative PBP binding loops; other site 754507002649 ABC-ATPase subunit interface; other site 754507002650 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754507002651 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754507002652 hypothetical protein; Provisional; Region: PRK11702 754507002653 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 754507002654 adenine DNA glycosylase; Provisional; Region: PRK10880 754507002655 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754507002656 minor groove reading motif; other site 754507002657 helix-hairpin-helix signature motif; other site 754507002658 substrate binding pocket [chemical binding]; other site 754507002659 active site 754507002660 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 754507002661 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 754507002662 DNA binding and oxoG recognition site [nucleotide binding] 754507002663 oxidative damage protection protein; Provisional; Region: PRK05408 754507002664 murein transglycosylase C; Provisional; Region: mltC; PRK11671 754507002665 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 754507002666 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754507002667 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754507002668 catalytic residue [active] 754507002669 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056 754507002670 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 754507002671 BolA-like protein; Region: BolA; cl00386 754507002672 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 754507002673 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754507002674 E3 interaction surface; other site 754507002675 lipoyl attachment site [posttranslational modification]; other site 754507002676 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 754507002677 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 754507002678 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 754507002679 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 754507002680 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 754507002681 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 754507002682 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 754507002683 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 754507002684 FAD binding pocket [chemical binding]; other site 754507002685 FAD binding motif [chemical binding]; other site 754507002686 phosphate binding motif [ion binding]; other site 754507002687 beta-alpha-beta structure motif; other site 754507002688 NAD binding pocket [chemical binding]; other site 754507002689 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 754507002690 ApbE family; Region: ApbE; pfam02424 754507002691 Protein of unknown function (DUF539); Region: DUF539; cl01129 754507002692 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 754507002693 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 754507002694 Ligand Binding Site [chemical binding]; other site 754507002695 enolase; Provisional; Region: eno; PRK00077 754507002696 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 754507002697 dimer interface [polypeptide binding]; other site 754507002698 metal binding site [ion binding]; metal-binding site 754507002699 substrate binding pocket [chemical binding]; other site 754507002700 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 754507002701 hypothetical protein; Validated; Region: PRK00228 754507002702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 754507002703 RNA methyltransferase, RsmE family; Region: TIGR00046 754507002704 transcriptional repressor protein MetJ; Provisional; Region: PRK05264 754507002705 corepressor binding sites; other site 754507002706 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 754507002707 active site 754507002708 tetramer interface; other site 754507002709 phosphomannomutase CpsG; Provisional; Region: PRK15414 754507002710 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 754507002711 active site 754507002712 substrate binding site [chemical binding]; other site 754507002713 metal binding site [ion binding]; metal-binding site 754507002714 carbon storage regulator; Provisional; Region: PRK01712 754507002715 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 754507002716 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 754507002717 motif 1; other site 754507002718 active site 754507002719 motif 2; other site 754507002720 motif 3; other site 754507002721 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 754507002722 DHHA1 domain; Region: DHHA1; pfam02272 754507002723 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754507002724 Ligand Binding Site [chemical binding]; other site 754507002725 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 754507002726 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 754507002727 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 754507002728 homodimer interface [polypeptide binding]; other site 754507002729 metal binding site [ion binding]; metal-binding site 754507002730 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 754507002731 homodimer interface [polypeptide binding]; other site 754507002732 active site 754507002733 putative chemical substrate binding site [chemical binding]; other site 754507002734 metal binding site [ion binding]; metal-binding site 754507002735 hypothetical protein; Validated; Region: PRK06886 754507002736 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 754507002737 active site 754507002738 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 754507002739 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 754507002740 Sulfatase; Region: Sulfatase; cl17466 754507002741 hypothetical protein; Provisional; Region: PRK13689 754507002742 Nucleoid-associated protein [General function prediction only]; Region: COG3081 754507002743 nucleoid-associated protein NdpA; Validated; Region: PRK00378 754507002744 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 754507002745 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 754507002746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754507002747 active site 754507002748 phosphorylation site [posttranslational modification] 754507002749 intermolecular recognition site; other site 754507002750 dimerization interface [polypeptide binding]; other site 754507002751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 754507002752 DNA binding site [nucleotide binding] 754507002753 two-component sensor protein; Provisional; Region: cpxA; PRK09470 754507002754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 754507002755 dimerization interface [polypeptide binding]; other site 754507002756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507002757 ATP binding site [chemical binding]; other site 754507002758 Mg2+ binding site [ion binding]; other site 754507002759 G-X-G motif; other site 754507002760 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 754507002761 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 754507002762 putative active site [active] 754507002763 dimerization interface [polypeptide binding]; other site 754507002764 putative tRNAtyr binding site [nucleotide binding]; other site 754507002765 hypothetical protein; Reviewed; Region: PRK01637 754507002766 hypothetical protein; Provisional; Region: PRK01752 754507002767 SEC-C motif; Region: SEC-C; pfam02810 754507002768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 754507002769 MOSC domain; Region: MOSC; pfam03473 754507002770 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 754507002771 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 754507002772 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 754507002773 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 754507002774 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754507002775 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507002776 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754507002777 putative effector binding pocket; other site 754507002778 putative dimerization interface [polypeptide binding]; other site 754507002779 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754507002780 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754507002781 active site 754507002782 catalytic tetrad [active] 754507002783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 754507002784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 754507002785 active site 754507002786 catalytic tetrad [active] 754507002787 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 754507002788 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 754507002789 substrate binding pocket [chemical binding]; other site 754507002790 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 754507002791 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 754507002792 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 754507002793 catalytic site [active] 754507002794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754507002795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507002796 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 754507002797 putative effector binding pocket; other site 754507002798 putative dimerization interface [polypeptide binding]; other site 754507002799 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 754507002800 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 754507002801 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 754507002802 glutaminase active site [active] 754507002803 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 754507002804 dimer interface [polypeptide binding]; other site 754507002805 active site 754507002806 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 754507002807 dimer interface [polypeptide binding]; other site 754507002808 active site 754507002809 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754507002810 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754507002811 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754507002812 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754507002813 IHF dimer interface [polypeptide binding]; other site 754507002814 IHF - DNA interface [nucleotide binding]; other site 754507002815 Protein of unknown function (DUF416); Region: DUF416; cl01166 754507002816 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 754507002817 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 754507002818 substrate binding site [chemical binding]; other site 754507002819 active site 754507002820 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 754507002821 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 754507002822 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 754507002823 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 754507002824 putative NADH binding site [chemical binding]; other site 754507002825 putative active site [active] 754507002826 nudix motif; other site 754507002827 putative metal binding site [ion binding]; other site 754507002828 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 754507002829 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 754507002830 active site 754507002831 substrate-binding site [chemical binding]; other site 754507002832 metal-binding site [ion binding] 754507002833 ATP binding site [chemical binding]; other site 754507002834 exopolyphosphatase; Provisional; Region: PRK10854 754507002835 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 754507002836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 754507002837 Family of unknown function (DUF490); Region: DUF490; pfam04357 754507002838 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 754507002839 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 754507002840 Surface antigen; Region: Bac_surface_Ag; pfam01103 754507002841 transcriptional regulator NarP; Provisional; Region: PRK10403 754507002842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754507002843 active site 754507002844 phosphorylation site [posttranslational modification] 754507002845 intermolecular recognition site; other site 754507002846 dimerization interface [polypeptide binding]; other site 754507002847 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754507002848 DNA binding residues [nucleotide binding] 754507002849 dimerization interface [polypeptide binding]; other site 754507002850 adenylate cyclase; Provisional; Region: cyaA; PRK09450 754507002851 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 754507002852 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 754507002853 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 754507002854 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 754507002855 domain interfaces; other site 754507002856 active site 754507002857 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 754507002858 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 754507002859 active site 754507002860 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 754507002861 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 754507002862 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 754507002863 HemY protein N-terminus; Region: HemY_N; pfam07219 754507002864 hypothetical protein; Provisional; Region: PRK11212 754507002865 RNA polymerase sigma factor; Provisional; Region: PRK12530 754507002866 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754507002867 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754507002868 DNA binding residues [nucleotide binding] 754507002869 Putative zinc-finger; Region: zf-HC2; pfam13490 754507002870 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 754507002871 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 754507002872 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754507002873 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754507002874 RNA binding site [nucleotide binding]; other site 754507002875 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754507002876 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 754507002877 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754507002878 transmembrane helices; other site 754507002879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 754507002880 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 754507002881 putative dimerization interface [polypeptide binding]; other site 754507002882 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 754507002883 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 754507002884 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 754507002885 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 754507002886 RNA binding site [nucleotide binding]; other site 754507002887 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 754507002888 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 754507002889 putative N- and C-terminal domain interface [polypeptide binding]; other site 754507002890 putative active site [active] 754507002891 MgATP binding site [chemical binding]; other site 754507002892 catalytic site [active] 754507002893 metal binding site [ion binding]; metal-binding site 754507002894 putative xylulose binding site [chemical binding]; other site 754507002895 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507002896 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507002897 TM-ABC transporter signature motif; other site 754507002898 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754507002899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507002900 Walker A/P-loop; other site 754507002901 ATP binding site [chemical binding]; other site 754507002902 Q-loop/lid; other site 754507002903 ABC transporter signature motif; other site 754507002904 Walker B; other site 754507002905 D-loop; other site 754507002906 H-loop/switch region; other site 754507002907 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754507002908 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 754507002909 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 754507002910 ligand binding site [chemical binding]; other site 754507002911 elongation factor Tu; Reviewed; Region: PRK00049 754507002912 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 754507002913 G1 box; other site 754507002914 GEF interaction site [polypeptide binding]; other site 754507002915 GTP/Mg2+ binding site [chemical binding]; other site 754507002916 Switch I region; other site 754507002917 G2 box; other site 754507002918 G3 box; other site 754507002919 Switch II region; other site 754507002920 G4 box; other site 754507002921 G5 box; other site 754507002922 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 754507002923 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 754507002924 Antibiotic Binding Site [chemical binding]; other site 754507002925 pantothenate kinase; Provisional; Region: PRK05439 754507002926 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 754507002927 ATP-binding site [chemical binding]; other site 754507002928 CoA-binding site [chemical binding]; other site 754507002929 Mg2+-binding site [ion binding]; other site 754507002930 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 754507002931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507002932 ATP binding site [chemical binding]; other site 754507002933 Mg2+ binding site [ion binding]; other site 754507002934 G-X-G motif; other site 754507002935 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754507002936 anchoring element; other site 754507002937 dimer interface [polypeptide binding]; other site 754507002938 ATP binding site [chemical binding]; other site 754507002939 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 754507002940 active site 754507002941 putative metal-binding site [ion binding]; other site 754507002942 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754507002943 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 754507002944 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507002945 ATP binding site [chemical binding]; other site 754507002946 putative Mg++ binding site [ion binding]; other site 754507002947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507002948 nucleotide binding region [chemical binding]; other site 754507002949 ATP-binding site [chemical binding]; other site 754507002950 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 754507002951 HRDC domain; Region: HRDC; pfam00570 754507002952 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 754507002953 putative iron binding site [ion binding]; other site 754507002954 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 754507002955 diaminopimelate decarboxylase; Region: lysA; TIGR01048 754507002956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 754507002957 active site 754507002958 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754507002959 substrate binding site [chemical binding]; other site 754507002960 catalytic residues [active] 754507002961 dimer interface [polypeptide binding]; other site 754507002962 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 754507002963 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 754507002964 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 754507002965 OstA-like protein; Region: OstA; pfam03968 754507002966 Organic solvent tolerance protein; Region: OstA_C; pfam04453 754507002967 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507002968 active site 754507002969 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 754507002970 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 754507002971 metal binding site [ion binding]; metal-binding site 754507002972 dimer interface [polypeptide binding]; other site 754507002973 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 754507002974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754507002975 NAD(P) binding site [chemical binding]; other site 754507002976 active site 754507002977 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 754507002978 Walker A motif; other site 754507002979 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 754507002980 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 754507002981 anti-sigma E factor; Provisional; Region: rseB; PRK09455 754507002982 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 754507002983 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 754507002984 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 754507002985 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 754507002986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754507002987 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754507002988 DNA binding residues [nucleotide binding] 754507002989 Uncharacterized conserved protein [Function unknown]; Region: COG2938 754507002990 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 754507002991 prolyl-tRNA synthetase; Provisional; Region: PRK09194 754507002992 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 754507002993 dimer interface [polypeptide binding]; other site 754507002994 motif 1; other site 754507002995 active site 754507002996 motif 2; other site 754507002997 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 754507002998 putative deacylase active site [active] 754507002999 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754507003000 active site 754507003001 motif 3; other site 754507003002 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 754507003003 anticodon binding site; other site 754507003004 selenocysteine synthase; Provisional; Region: PRK04311 754507003005 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 754507003006 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 754507003007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754507003008 catalytic residue [active] 754507003009 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 754507003010 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 754507003011 G1 box; other site 754507003012 putative GEF interaction site [polypeptide binding]; other site 754507003013 GTP/Mg2+ binding site [chemical binding]; other site 754507003014 Switch I region; other site 754507003015 G2 box; other site 754507003016 G3 box; other site 754507003017 Switch II region; other site 754507003018 G4 box; other site 754507003019 G5 box; other site 754507003020 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 754507003021 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 754507003022 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 754507003023 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 754507003024 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 754507003025 Protein of unknown function (DUF972); Region: DUF972; pfam06156 754507003026 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 754507003027 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 754507003028 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 754507003029 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 754507003030 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 754507003031 Na2 binding site [ion binding]; other site 754507003032 putative substrate binding site 1 [chemical binding]; other site 754507003033 Na binding site 1 [ion binding]; other site 754507003034 putative substrate binding site 2 [chemical binding]; other site 754507003035 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 754507003036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 754507003037 TPR motif; other site 754507003038 binding surface 754507003039 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 754507003040 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754507003041 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 754507003042 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 754507003043 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 754507003044 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754507003045 ATP binding site [chemical binding]; other site 754507003046 Walker A motif; other site 754507003047 hexamer interface [polypeptide binding]; other site 754507003048 Walker B motif; other site 754507003049 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 754507003050 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 754507003051 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 754507003052 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 754507003053 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 754507003054 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 754507003055 metal-binding heat shock protein; Provisional; Region: PRK00016 754507003056 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 754507003057 Helicase; Region: Helicase_RecD; pfam05127 754507003058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 754507003059 Coenzyme A binding pocket [chemical binding]; other site 754507003060 transcription-repair coupling factor; Provisional; Region: PRK10689 754507003061 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 754507003062 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507003063 ATP binding site [chemical binding]; other site 754507003064 putative Mg++ binding site [ion binding]; other site 754507003065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507003066 nucleotide binding region [chemical binding]; other site 754507003067 ATP-binding site [chemical binding]; other site 754507003068 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 754507003069 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 754507003070 dimer interface [polypeptide binding]; other site 754507003071 active site 754507003072 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 754507003073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507003074 Walker A/P-loop; other site 754507003075 ATP binding site [chemical binding]; other site 754507003076 Q-loop/lid; other site 754507003077 ABC transporter signature motif; other site 754507003078 Walker B; other site 754507003079 D-loop; other site 754507003080 H-loop/switch region; other site 754507003081 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 754507003082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 754507003083 substrate binding pocket [chemical binding]; other site 754507003084 membrane-bound complex binding site; other site 754507003085 hinge residues; other site 754507003086 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 754507003087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003088 dimer interface [polypeptide binding]; other site 754507003089 conserved gate region; other site 754507003090 putative PBP binding loops; other site 754507003091 ABC-ATPase subunit interface; other site 754507003092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003093 dimer interface [polypeptide binding]; other site 754507003094 conserved gate region; other site 754507003095 putative PBP binding loops; other site 754507003096 ABC-ATPase subunit interface; other site 754507003097 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 754507003098 Carbon starvation protein CstA; Region: CstA; pfam02554 754507003099 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 754507003100 cell division protein MraZ; Reviewed; Region: PRK00326 754507003101 MraZ protein; Region: MraZ; pfam02381 754507003102 MraZ protein; Region: MraZ; pfam02381 754507003103 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 754507003104 MraW methylase family; Region: Methyltransf_5; pfam01795 754507003105 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 754507003106 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 754507003107 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 754507003108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 754507003109 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 754507003110 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754507003111 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754507003112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754507003113 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 754507003114 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754507003115 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754507003116 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754507003117 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 754507003118 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 754507003119 Mg++ binding site [ion binding]; other site 754507003120 putative catalytic motif [active] 754507003121 putative substrate binding site [chemical binding]; other site 754507003122 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 754507003123 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754507003124 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754507003125 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754507003126 cell division protein FtsW; Region: ftsW; TIGR02614 754507003127 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 754507003128 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 754507003129 active site 754507003130 homodimer interface [polypeptide binding]; other site 754507003131 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 754507003132 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 754507003133 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754507003134 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754507003135 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 754507003136 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 754507003137 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 754507003138 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 754507003139 Cell division protein FtsQ; Region: FtsQ; pfam03799 754507003140 cell division protein FtsA; Region: ftsA; TIGR01174 754507003141 Cell division protein FtsA; Region: FtsA; smart00842 754507003142 Cell division protein FtsA; Region: FtsA; pfam14450 754507003143 cell division protein FtsZ; Validated; Region: PRK09330 754507003144 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 754507003145 nucleotide binding site [chemical binding]; other site 754507003146 SulA interaction site; other site 754507003147 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 754507003148 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 754507003149 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 754507003150 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 754507003151 Prephenate dehydratase; Region: PDT; pfam00800 754507003152 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 754507003153 putative L-Phe binding site [chemical binding]; other site 754507003154 heat shock protein 90; Provisional; Region: PRK05218 754507003155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507003156 ATP binding site [chemical binding]; other site 754507003157 Mg2+ binding site [ion binding]; other site 754507003158 G-X-G motif; other site 754507003159 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 754507003160 ArsC family; Region: ArsC; pfam03960 754507003161 putative catalytic residues [active] 754507003162 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 754507003163 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 754507003164 metal binding site [ion binding]; metal-binding site 754507003165 dimer interface [polypeptide binding]; other site 754507003166 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 754507003167 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 754507003168 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 754507003169 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 754507003170 dimer interface [polypeptide binding]; other site 754507003171 ADP-ribose binding site [chemical binding]; other site 754507003172 active site 754507003173 nudix motif; other site 754507003174 metal binding site [ion binding]; metal-binding site 754507003175 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 754507003176 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754507003177 active site 754507003178 metal binding site [ion binding]; metal-binding site 754507003179 hexamer interface [polypeptide binding]; other site 754507003180 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 754507003181 oxidoreductase; Region: PLN02991 754507003182 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 754507003183 Ligand Binding Site [chemical binding]; other site 754507003184 AAA domain; Region: AAA_14; pfam13173 754507003185 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 754507003186 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 754507003187 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 754507003188 putative NAD(P) binding site [chemical binding]; other site 754507003189 putative substrate binding site [chemical binding]; other site 754507003190 catalytic Zn binding site [ion binding]; other site 754507003191 structural Zn binding site [ion binding]; other site 754507003192 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 754507003193 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 754507003194 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 754507003195 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 754507003196 putative RNA binding site [nucleotide binding]; other site 754507003197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507003198 S-adenosylmethionine binding site [chemical binding]; other site 754507003199 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 754507003200 Iron-sulfur protein interface; other site 754507003201 proximal quinone binding site [chemical binding]; other site 754507003202 C-subunit interface; other site 754507003203 distal quinone binding site; other site 754507003204 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 754507003205 D-subunit interface [polypeptide binding]; other site 754507003206 Iron-sulfur protein interface; other site 754507003207 proximal quinone binding site [chemical binding]; other site 754507003208 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 754507003209 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 754507003210 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 754507003211 L-aspartate oxidase; Provisional; Region: PRK06175 754507003212 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 754507003213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 754507003214 poxB regulator PoxA; Provisional; Region: PRK09350 754507003215 motif 1; other site 754507003216 dimer interface [polypeptide binding]; other site 754507003217 active site 754507003218 motif 2; other site 754507003219 motif 3; other site 754507003220 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 754507003221 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754507003222 Walker A/P-loop; other site 754507003223 ATP binding site [chemical binding]; other site 754507003224 Q-loop/lid; other site 754507003225 ABC transporter signature motif; other site 754507003226 Walker B; other site 754507003227 D-loop; other site 754507003228 H-loop/switch region; other site 754507003229 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 754507003230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507003231 ABC-ATPase subunit interface; other site 754507003232 dimer interface [polypeptide binding]; other site 754507003233 putative PBP binding regions; other site 754507003234 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754507003235 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507003236 ABC-ATPase subunit interface; other site 754507003237 dimer interface [polypeptide binding]; other site 754507003238 putative PBP binding regions; other site 754507003239 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 754507003240 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 754507003241 siderophore binding site; other site 754507003242 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 754507003243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 754507003244 putative active site [active] 754507003245 putative metal binding site [ion binding]; other site 754507003246 hypothetical protein; Validated; Region: PRK00153 754507003247 recombination protein RecR; Reviewed; Region: recR; PRK00076 754507003248 RecR protein; Region: RecR; pfam02132 754507003249 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 754507003250 putative active site [active] 754507003251 putative metal-binding site [ion binding]; other site 754507003252 tetramer interface [polypeptide binding]; other site 754507003253 DNA topoisomerase III; Provisional; Region: PRK07726 754507003254 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 754507003255 active site 754507003256 putative interdomain interaction site [polypeptide binding]; other site 754507003257 putative metal-binding site [ion binding]; other site 754507003258 putative nucleotide binding site [chemical binding]; other site 754507003259 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 754507003260 domain I; other site 754507003261 phosphate binding site [ion binding]; other site 754507003262 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 754507003263 phosphate binding site [ion binding]; other site 754507003264 domain II; other site 754507003265 domain III; other site 754507003266 nucleotide binding site [chemical binding]; other site 754507003267 DNA binding groove [nucleotide binding] 754507003268 catalytic site [active] 754507003269 domain IV; other site 754507003270 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 754507003271 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 754507003272 Transglycosylase; Region: Transgly; cl17702 754507003273 Trp operon repressor; Provisional; Region: PRK01381 754507003274 lytic murein transglycosylase; Provisional; Region: PRK11619 754507003275 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754507003276 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754507003277 catalytic residue [active] 754507003278 YciI-like protein; Reviewed; Region: PRK11370 754507003279 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 754507003280 intracellular septation protein A; Reviewed; Region: PRK00259 754507003281 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 754507003282 recombination and repair protein; Provisional; Region: PRK10869 754507003283 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754507003284 Walker A/P-loop; other site 754507003285 ATP binding site [chemical binding]; other site 754507003286 Q-loop/lid; other site 754507003287 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 754507003288 ABC transporter signature motif; other site 754507003289 Walker B; other site 754507003290 D-loop; other site 754507003291 H-loop/switch region; other site 754507003292 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 754507003293 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 754507003294 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 754507003295 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 754507003296 dimer interface [polypeptide binding]; other site 754507003297 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 754507003298 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754507003299 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754507003300 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 754507003301 Uncharacterized conserved protein [Function unknown]; Region: COG4121 754507003302 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 754507003303 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 754507003304 dimer interface [polypeptide binding]; other site 754507003305 active site 754507003306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 754507003307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754507003308 dimer interface [polypeptide binding]; other site 754507003309 phosphorylation site [posttranslational modification] 754507003310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507003311 ATP binding site [chemical binding]; other site 754507003312 Mg2+ binding site [ion binding]; other site 754507003313 G-X-G motif; other site 754507003314 Response regulator receiver domain; Region: Response_reg; pfam00072 754507003315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754507003316 active site 754507003317 phosphorylation site [posttranslational modification] 754507003318 intermolecular recognition site; other site 754507003319 dimerization interface [polypeptide binding]; other site 754507003320 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 754507003321 putative binding surface; other site 754507003322 active site 754507003323 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507003324 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507003325 TM-ABC transporter signature motif; other site 754507003326 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 754507003327 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 754507003328 ligand binding site [chemical binding]; other site 754507003329 calcium binding site [ion binding]; other site 754507003330 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 754507003331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754507003332 DNA binding site [nucleotide binding] 754507003333 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 754507003334 ligand binding site [chemical binding]; other site 754507003335 dimerization interface (closed form) [polypeptide binding]; other site 754507003336 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 754507003337 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 754507003338 dimer interface [polypeptide binding]; other site 754507003339 active site 754507003340 galactokinase; Provisional; Region: PRK05101 754507003341 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 754507003342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 754507003343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 754507003344 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 754507003345 active site 754507003346 catalytic residues [active] 754507003347 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 754507003348 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754507003349 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 754507003350 transmembrane helices; other site 754507003351 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 754507003352 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 754507003353 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 754507003354 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 754507003355 citrate lyase subunit gamma; Provisional; Region: PRK13253 754507003356 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 754507003357 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 754507003358 putative active site [active] 754507003359 (T/H)XGH motif; other site 754507003360 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 754507003361 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 754507003362 Transporter associated domain; Region: CorC_HlyC; smart01091 754507003363 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 754507003364 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 754507003365 putative active site [active] 754507003366 catalytic triad [active] 754507003367 putative dimer interface [polypeptide binding]; other site 754507003368 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 754507003369 rRNA binding site [nucleotide binding]; other site 754507003370 predicted 30S ribosome binding site; other site 754507003371 aminopeptidase B; Provisional; Region: PRK05015 754507003372 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 754507003373 interface (dimer of trimers) [polypeptide binding]; other site 754507003374 Substrate-binding/catalytic site; other site 754507003375 Zn-binding sites [ion binding]; other site 754507003376 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 754507003377 active site 754507003378 multimer interface [polypeptide binding]; other site 754507003379 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cd02742 754507003380 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 754507003381 active site 754507003382 antiporter inner membrane protein; Provisional; Region: PRK11670 754507003383 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 754507003384 Walker A motif; other site 754507003385 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 754507003386 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 754507003387 active site 754507003388 HIGH motif; other site 754507003389 KMSKS motif; other site 754507003390 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 754507003391 tRNA binding surface [nucleotide binding]; other site 754507003392 anticodon binding site; other site 754507003393 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 754507003394 dimer interface [polypeptide binding]; other site 754507003395 putative tRNA-binding site [nucleotide binding]; other site 754507003396 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 754507003397 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 754507003398 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754507003399 catalytic loop [active] 754507003400 iron binding site [ion binding]; other site 754507003401 chaperone protein HscA; Provisional; Region: hscA; PRK05183 754507003402 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 754507003403 nucleotide binding site [chemical binding]; other site 754507003404 putative NEF/HSP70 interaction site [polypeptide binding]; other site 754507003405 SBD interface [polypeptide binding]; other site 754507003406 co-chaperone HscB; Provisional; Region: hscB; PRK01773 754507003407 DnaJ domain; Region: DnaJ; pfam00226 754507003408 HSP70 interaction site [polypeptide binding]; other site 754507003409 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 754507003410 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 754507003411 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 754507003412 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 754507003413 active site 754507003414 trimerization site [polypeptide binding]; other site 754507003415 cysteine desulfurase; Provisional; Region: PRK14012 754507003416 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 754507003417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754507003418 catalytic residue [active] 754507003419 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 754507003420 Rrf2 family protein; Region: rrf2_super; TIGR00738 754507003421 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 754507003422 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 754507003423 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754507003424 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 754507003425 active site 754507003426 dimerization interface [polypeptide binding]; other site 754507003427 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 754507003428 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754507003429 Walker A/P-loop; other site 754507003430 ATP binding site [chemical binding]; other site 754507003431 Q-loop/lid; other site 754507003432 ABC transporter signature motif; other site 754507003433 Walker B; other site 754507003434 D-loop; other site 754507003435 H-loop/switch region; other site 754507003436 TOBE domain; Region: TOBE_2; pfam08402 754507003437 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754507003438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003439 dimer interface [polypeptide binding]; other site 754507003440 conserved gate region; other site 754507003441 putative PBP binding loops; other site 754507003442 ABC-ATPase subunit interface; other site 754507003443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003444 dimer interface [polypeptide binding]; other site 754507003445 conserved gate region; other site 754507003446 putative PBP binding loops; other site 754507003447 ABC-ATPase subunit interface; other site 754507003448 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754507003449 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754507003450 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754507003451 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 754507003452 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 754507003453 Sugar specificity; other site 754507003454 Pyrimidine base specificity; other site 754507003455 ATP-binding site [chemical binding]; other site 754507003456 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 754507003457 trimer interface [polypeptide binding]; other site 754507003458 active site 754507003459 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 754507003460 putative arabinose transporter; Provisional; Region: PRK03545 754507003461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507003462 putative substrate translocation pore; other site 754507003463 GTP-binding protein Der; Reviewed; Region: PRK00093 754507003464 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 754507003465 G1 box; other site 754507003466 GTP/Mg2+ binding site [chemical binding]; other site 754507003467 Switch I region; other site 754507003468 G2 box; other site 754507003469 Switch II region; other site 754507003470 G3 box; other site 754507003471 G4 box; other site 754507003472 G5 box; other site 754507003473 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 754507003474 G1 box; other site 754507003475 GTP/Mg2+ binding site [chemical binding]; other site 754507003476 Switch I region; other site 754507003477 G2 box; other site 754507003478 G3 box; other site 754507003479 Switch II region; other site 754507003480 G4 box; other site 754507003481 G5 box; other site 754507003482 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 754507003483 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754507003484 HSP70 interaction site [polypeptide binding]; other site 754507003485 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754507003486 substrate binding site [polypeptide binding]; other site 754507003487 dimer interface [polypeptide binding]; other site 754507003488 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 754507003489 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 754507003490 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 754507003491 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 754507003492 GDP-binding site [chemical binding]; other site 754507003493 ACT binding site; other site 754507003494 IMP binding site; other site 754507003495 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754507003496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507003497 S-adenosylmethionine binding site [chemical binding]; other site 754507003498 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 754507003499 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 754507003500 Na binding site [ion binding]; other site 754507003501 ribonuclease G; Provisional; Region: PRK11712 754507003502 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 754507003503 homodimer interface [polypeptide binding]; other site 754507003504 oligonucleotide binding site [chemical binding]; other site 754507003505 glutaredoxin 2; Provisional; Region: PRK10387 754507003506 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 754507003507 C-terminal domain interface [polypeptide binding]; other site 754507003508 GSH binding site (G-site) [chemical binding]; other site 754507003509 catalytic residues [active] 754507003510 putative dimer interface [polypeptide binding]; other site 754507003511 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 754507003512 N-terminal domain interface [polypeptide binding]; other site 754507003513 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 754507003514 NAD-dependent deacetylase; Provisional; Region: PRK00481 754507003515 NAD+ binding site [chemical binding]; other site 754507003516 substrate binding site [chemical binding]; other site 754507003517 Zn binding site [ion binding]; other site 754507003518 Helix-turn-helix domain; Region: HTH_28; pfam13518 754507003519 VirB8 protein; Region: VirB8; pfam04335 754507003520 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 754507003521 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 754507003522 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 754507003523 PemK-like protein; Region: PemK; cl00995 754507003524 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 754507003525 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 754507003526 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 754507003527 putative catalytic site [active] 754507003528 CdtC interface [polypeptide binding]; other site 754507003529 heterotrimer interface [polypeptide binding]; other site 754507003530 CdtA interface [polypeptide binding]; other site 754507003531 putative metal binding site [ion binding]; other site 754507003532 putative phosphate binding site [ion binding]; other site 754507003533 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 754507003534 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 754507003535 cofactor binding site; other site 754507003536 DNA binding site [nucleotide binding] 754507003537 substrate interaction site [chemical binding]; other site 754507003538 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 754507003539 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754507003540 P-loop; other site 754507003541 Magnesium ion binding site [ion binding]; other site 754507003542 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 754507003543 Magnesium ion binding site [ion binding]; other site 754507003544 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 754507003545 cystathionine beta-lyase; Provisional; Region: PRK08114 754507003546 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 754507003547 homodimer interface [polypeptide binding]; other site 754507003548 substrate-cofactor binding pocket; other site 754507003549 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507003550 catalytic residue [active] 754507003551 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 754507003552 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 754507003553 trimer interface [polypeptide binding]; other site 754507003554 eyelet of channel; other site 754507003555 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 754507003556 PemK-like protein; Region: PemK; cl00995 754507003557 chaperone protein DnaJ; Provisional; Region: PRK10767 754507003558 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 754507003559 HSP70 interaction site [polypeptide binding]; other site 754507003560 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 754507003561 substrate binding site [polypeptide binding]; other site 754507003562 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 754507003563 Zn binding sites [ion binding]; other site 754507003564 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 754507003565 dimer interface [polypeptide binding]; other site 754507003566 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 754507003567 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754507003568 nucleotide binding site [chemical binding]; other site 754507003569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 754507003570 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 754507003571 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 754507003572 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 754507003573 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 754507003574 active site 754507003575 HIGH motif; other site 754507003576 KMSK motif region; other site 754507003577 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 754507003578 tRNA binding surface [nucleotide binding]; other site 754507003579 anticodon binding site; other site 754507003580 hypothetical protein; Provisional; Region: PRK11700 754507003581 active site 754507003582 metal binding site [ion binding]; metal-binding site 754507003583 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 754507003584 peptide chain release factor 1; Validated; Region: prfA; PRK00591 754507003585 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754507003586 RF-1 domain; Region: RF-1; pfam00472 754507003587 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 754507003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507003589 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 754507003590 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 754507003591 NlpC/P60 family; Region: NLPC_P60; pfam00877 754507003592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 754507003593 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 754507003594 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 754507003595 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 754507003596 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754507003597 catalytic core [active] 754507003598 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 754507003599 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 754507003600 active site 754507003601 substrate binding site [chemical binding]; other site 754507003602 metal binding site [ion binding]; metal-binding site 754507003603 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 754507003604 dihydropteroate synthase; Region: DHPS; TIGR01496 754507003605 substrate binding pocket [chemical binding]; other site 754507003606 dimer interface [polypeptide binding]; other site 754507003607 inhibitor binding site; inhibition site 754507003608 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 754507003609 DNA polymerase IV; Validated; Region: PRK02406 754507003610 active site 754507003611 DNA binding site [nucleotide binding] 754507003612 Integrase core domain; Region: rve; pfam00665 754507003613 Integrase core domain; Region: rve_2; pfam13333 754507003614 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507003615 Zeta toxin; Region: Zeta_toxin; pfam06414 754507003616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507003617 Walker A/P-loop; other site 754507003618 Walker A/P-loop; other site 754507003619 ATP binding site [chemical binding]; other site 754507003620 ATP binding site [chemical binding]; other site 754507003621 Mga helix-turn-helix domain; Region: Mga; pfam05043 754507003622 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 754507003623 Helix-turn-helix domain; Region: HTH_28; pfam13518 754507003624 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 754507003625 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754507003626 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 754507003627 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 754507003628 active site 754507003629 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 754507003630 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 754507003631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 754507003632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754507003633 Walker A/P-loop; other site 754507003634 ATP binding site [chemical binding]; other site 754507003635 Q-loop/lid; other site 754507003636 ABC transporter signature motif; other site 754507003637 Walker B; other site 754507003638 D-loop; other site 754507003639 H-loop/switch region; other site 754507003640 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 754507003641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 754507003642 Walker A/P-loop; other site 754507003643 ATP binding site [chemical binding]; other site 754507003644 Q-loop/lid; other site 754507003645 ABC transporter signature motif; other site 754507003646 Walker B; other site 754507003647 D-loop; other site 754507003648 H-loop/switch region; other site 754507003649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 754507003650 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 754507003651 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 754507003652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003653 dimer interface [polypeptide binding]; other site 754507003654 conserved gate region; other site 754507003655 putative PBP binding loops; other site 754507003656 ABC-ATPase subunit interface; other site 754507003657 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 754507003658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003659 dimer interface [polypeptide binding]; other site 754507003660 conserved gate region; other site 754507003661 putative PBP binding loops; other site 754507003662 ABC-ATPase subunit interface; other site 754507003663 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754507003664 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 754507003665 peptide binding site [polypeptide binding]; other site 754507003666 YcjX-like family, DUF463; Region: DUF463; cl01193 754507003667 hypothetical protein; Provisional; Region: PRK05415 754507003668 Domain of unknown function (DUF697); Region: DUF697; cl12064 754507003669 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 754507003670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507003671 Walker A motif; other site 754507003672 ATP binding site [chemical binding]; other site 754507003673 Walker B motif; other site 754507003674 arginine finger; other site 754507003675 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 754507003676 bacterial Hfq-like; Region: Hfq; cd01716 754507003677 hexamer interface [polypeptide binding]; other site 754507003678 Sm1 motif; other site 754507003679 RNA binding site [nucleotide binding]; other site 754507003680 Sm2 motif; other site 754507003681 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 754507003682 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 754507003683 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 754507003684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507003685 ATP binding site [chemical binding]; other site 754507003686 Mg2+ binding site [ion binding]; other site 754507003687 G-X-G motif; other site 754507003688 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 754507003689 ATP binding site [chemical binding]; other site 754507003690 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 754507003691 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 754507003692 active site 754507003693 metal binding site [ion binding]; metal-binding site 754507003694 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754507003695 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754507003696 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 754507003697 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 754507003698 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 754507003699 Predicted membrane protein [Function unknown]; Region: COG2246 754507003700 GtrA-like protein; Region: GtrA; pfam04138 754507003701 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 754507003702 Ligand binding site; other site 754507003703 Putative Catalytic site; other site 754507003704 DXD motif; other site 754507003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507003706 S-adenosylmethionine binding site [chemical binding]; other site 754507003707 spermidine synthase; Provisional; Region: PRK03612 754507003708 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 754507003709 Sulfatase; Region: Sulfatase; cl17466 754507003710 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 754507003711 catalytic site [active] 754507003712 putative active site [active] 754507003713 putative substrate binding site [chemical binding]; other site 754507003714 dimer interface [polypeptide binding]; other site 754507003715 GTPase RsgA; Reviewed; Region: PRK12288 754507003716 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 754507003717 RNA binding site [nucleotide binding]; other site 754507003718 homodimer interface [polypeptide binding]; other site 754507003719 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 754507003720 GTPase/Zn-binding domain interface [polypeptide binding]; other site 754507003721 GTP/Mg2+ binding site [chemical binding]; other site 754507003722 G4 box; other site 754507003723 G5 box; other site 754507003724 G1 box; other site 754507003725 Switch I region; other site 754507003726 G2 box; other site 754507003727 G3 box; other site 754507003728 Switch II region; other site 754507003729 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 754507003730 dimerization domain swap beta strand [polypeptide binding]; other site 754507003731 regulatory protein interface [polypeptide binding]; other site 754507003732 active site 754507003733 regulatory phosphorylation site [posttranslational modification]; other site 754507003734 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 754507003735 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 754507003736 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 754507003737 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 754507003738 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 754507003739 HPr interaction site; other site 754507003740 glycerol kinase (GK) interaction site [polypeptide binding]; other site 754507003741 active site 754507003742 phosphorylation site [posttranslational modification] 754507003743 oligopeptidase A; Provisional; Region: PRK10911 754507003744 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 754507003745 active site 754507003746 Zn binding site [ion binding]; other site 754507003747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 754507003748 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 754507003749 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 754507003750 peptide binding site [polypeptide binding]; other site 754507003751 hypothetical protein; Provisional; Region: PRK07101 754507003752 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 754507003753 substrate-cofactor binding pocket; other site 754507003754 para-aminobenzoate synthase component I; Validated; Region: PRK07093 754507003755 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 754507003756 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 754507003757 Glutamine amidotransferase class-I; Region: GATase; pfam00117 754507003758 glutamine binding [chemical binding]; other site 754507003759 catalytic triad [active] 754507003760 glycerate dehydrogenase; Provisional; Region: PRK06932 754507003761 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 754507003762 putative ligand binding site [chemical binding]; other site 754507003763 putative NAD binding site [chemical binding]; other site 754507003764 catalytic site [active] 754507003765 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 754507003766 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754507003767 FtsX-like permease family; Region: FtsX; pfam02687 754507003768 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 754507003769 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754507003770 Walker A/P-loop; other site 754507003771 ATP binding site [chemical binding]; other site 754507003772 Q-loop/lid; other site 754507003773 ABC transporter signature motif; other site 754507003774 Walker B; other site 754507003775 D-loop; other site 754507003776 H-loop/switch region; other site 754507003777 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 754507003778 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754507003779 FtsX-like permease family; Region: FtsX; pfam02687 754507003780 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 754507003781 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 754507003782 replicative DNA helicase; Validated; Region: PRK06904 754507003783 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 754507003784 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 754507003785 Walker A motif; other site 754507003786 ATP binding site [chemical binding]; other site 754507003787 Walker B motif; other site 754507003788 DNA binding loops [nucleotide binding] 754507003789 alanine racemase; Reviewed; Region: alr; PRK00053 754507003790 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 754507003791 active site 754507003792 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754507003793 substrate binding site [chemical binding]; other site 754507003794 catalytic residues [active] 754507003795 dimer interface [polypeptide binding]; other site 754507003796 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 754507003797 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 754507003798 active site 754507003799 dimer interface [polypeptide binding]; other site 754507003800 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 754507003801 dimer interface [polypeptide binding]; other site 754507003802 active site 754507003803 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 754507003804 homopentamer interface [polypeptide binding]; other site 754507003805 active site 754507003806 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 754507003807 putative RNA binding site [nucleotide binding]; other site 754507003808 thiamine monophosphate kinase; Provisional; Region: PRK05731 754507003809 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 754507003810 ATP binding site [chemical binding]; other site 754507003811 dimerization interface [polypeptide binding]; other site 754507003812 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 754507003813 tetramer interfaces [polypeptide binding]; other site 754507003814 binuclear metal-binding site [ion binding]; other site 754507003815 LysE type translocator; Region: LysE; cl00565 754507003816 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 754507003817 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 754507003818 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 754507003819 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 754507003820 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 754507003821 catalytic loop [active] 754507003822 iron binding site [ion binding]; other site 754507003823 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 754507003824 dimer interface [polypeptide binding]; other site 754507003825 putative radical transfer pathway; other site 754507003826 diiron center [ion binding]; other site 754507003827 tyrosyl radical; other site 754507003828 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 754507003829 ATP cone domain; Region: ATP-cone; pfam03477 754507003830 Class I ribonucleotide reductase; Region: RNR_I; cd01679 754507003831 active site 754507003832 dimer interface [polypeptide binding]; other site 754507003833 catalytic residues [active] 754507003834 effector binding site; other site 754507003835 R2 peptide binding site; other site 754507003836 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 754507003837 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754507003838 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754507003839 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754507003840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003841 dimer interface [polypeptide binding]; other site 754507003842 conserved gate region; other site 754507003843 putative PBP binding loops; other site 754507003844 ABC-ATPase subunit interface; other site 754507003845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003846 dimer interface [polypeptide binding]; other site 754507003847 conserved gate region; other site 754507003848 putative PBP binding loops; other site 754507003849 ABC-ATPase subunit interface; other site 754507003850 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 754507003851 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 754507003852 Walker A/P-loop; other site 754507003853 ATP binding site [chemical binding]; other site 754507003854 Q-loop/lid; other site 754507003855 ABC transporter signature motif; other site 754507003856 Walker B; other site 754507003857 D-loop; other site 754507003858 H-loop/switch region; other site 754507003859 TOBE domain; Region: TOBE_2; pfam08402 754507003860 alpha-amylase; Reviewed; Region: malS; PRK09505 754507003861 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 754507003862 active site 754507003863 catalytic site [active] 754507003864 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 754507003865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003866 dimer interface [polypeptide binding]; other site 754507003867 conserved gate region; other site 754507003868 putative PBP binding loops; other site 754507003869 ABC-ATPase subunit interface; other site 754507003870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003871 dimer interface [polypeptide binding]; other site 754507003872 conserved gate region; other site 754507003873 putative PBP binding loops; other site 754507003874 ABC-ATPase subunit interface; other site 754507003875 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 754507003876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 754507003877 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 754507003878 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 754507003879 Walker A/P-loop; other site 754507003880 ATP binding site [chemical binding]; other site 754507003881 Q-loop/lid; other site 754507003882 ABC transporter signature motif; other site 754507003883 Walker B; other site 754507003884 D-loop; other site 754507003885 H-loop/switch region; other site 754507003886 TOBE domain; Region: TOBE_2; pfam08402 754507003887 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 754507003888 trimer interface; other site 754507003889 sugar binding site [chemical binding]; other site 754507003890 maltose regulon periplasmic protein; Provisional; Region: PRK10564 754507003891 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 754507003892 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 754507003893 ATP binding site [chemical binding]; other site 754507003894 substrate interface [chemical binding]; other site 754507003895 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 754507003896 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 754507003897 dimer interface [polypeptide binding]; other site 754507003898 putative functional site; other site 754507003899 putative MPT binding site; other site 754507003900 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 754507003901 homodecamer interface [polypeptide binding]; other site 754507003902 GTP cyclohydrolase I; Provisional; Region: PLN03044 754507003903 active site 754507003904 putative catalytic site residues [active] 754507003905 zinc binding site [ion binding]; other site 754507003906 GTP-CH-I/GFRP interaction surface; other site 754507003907 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 754507003908 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 754507003909 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 754507003910 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 754507003911 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 754507003912 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 754507003913 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 754507003914 Predicted transcriptional regulator [Transcription]; Region: COG3636 754507003915 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 754507003916 Lumazine binding domain; Region: Lum_binding; pfam00677 754507003917 Lumazine binding domain; Region: Lum_binding; pfam00677 754507003918 multidrug efflux protein; Reviewed; Region: PRK01766 754507003919 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 754507003920 cation binding site [ion binding]; other site 754507003921 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 754507003922 putative deacylase active site [active] 754507003923 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901 754507003924 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 754507003925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754507003926 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754507003927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507003928 dimer interface [polypeptide binding]; other site 754507003929 conserved gate region; other site 754507003930 putative PBP binding loops; other site 754507003931 ABC-ATPase subunit interface; other site 754507003932 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754507003933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507003934 Walker A/P-loop; other site 754507003935 ATP binding site [chemical binding]; other site 754507003936 Q-loop/lid; other site 754507003937 ABC transporter signature motif; other site 754507003938 Walker B; other site 754507003939 D-loop; other site 754507003940 H-loop/switch region; other site 754507003941 molybdenum transport protein ModD; Provisional; Region: PRK06096 754507003942 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 754507003943 dimerization interface [polypeptide binding]; other site 754507003944 active site 754507003945 protease TldD; Provisional; Region: tldD; PRK10735 754507003946 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 754507003947 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 754507003948 MG2 domain; Region: A2M_N; pfam01835 754507003949 Alpha-2-macroglobulin family; Region: A2M; pfam00207 754507003950 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 754507003951 surface patch; other site 754507003952 thioester region; other site 754507003953 specificity defining residues; other site 754507003954 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 754507003955 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 754507003956 Transglycosylase; Region: Transgly; pfam00912 754507003957 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754507003958 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 754507003959 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 754507003960 active site 754507003961 dimer interface [polypeptide binding]; other site 754507003962 magnesium binding site [ion binding]; other site 754507003963 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754507003964 active site 754507003965 phosphorylation site [posttranslational modification] 754507003966 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 754507003967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 754507003968 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 754507003969 active site 754507003970 P-loop; other site 754507003971 phosphorylation site [posttranslational modification] 754507003972 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 754507003973 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 754507003974 transcriptional repressor UlaR; Provisional; Region: PRK13509 754507003975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754507003976 putative DNA binding site [nucleotide binding]; other site 754507003977 putative Zn2+ binding site [ion binding]; other site 754507003978 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754507003979 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 754507003980 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 754507003981 AP (apurinic/apyrimidinic) site pocket; other site 754507003982 DNA interaction; other site 754507003983 Metal-binding active site; metal-binding site 754507003984 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 754507003985 Zn2+ binding site [ion binding]; other site 754507003986 intersubunit interface [polypeptide binding]; other site 754507003987 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; pfam03222 754507003988 aromatic amino acid transport protein; Region: araaP; TIGR00837 754507003989 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 754507003990 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 754507003991 GSH binding site [chemical binding]; other site 754507003992 catalytic residues [active] 754507003993 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 754507003994 dimer interface [polypeptide binding]; other site 754507003995 FMN binding site [chemical binding]; other site 754507003996 NADPH bind site [chemical binding]; other site 754507003997 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 754507003998 ATP-grasp domain; Region: ATP-grasp_4; cl17255 754507003999 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 754507004000 fumarate hydratase; Reviewed; Region: fumC; PRK00485 754507004001 Class II fumarases; Region: Fumarase_classII; cd01362 754507004002 active site 754507004003 tetramer interface [polypeptide binding]; other site 754507004004 DNA polymerase III subunit chi; Validated; Region: PRK05728 754507004005 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 754507004006 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 754507004007 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 754507004008 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 754507004009 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 754507004010 HIGH motif; other site 754507004011 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 754507004012 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 754507004013 active site 754507004014 KMSKS motif; other site 754507004015 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 754507004016 tRNA binding surface [nucleotide binding]; other site 754507004017 anticodon binding site; other site 754507004018 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 754507004019 HipA N-terminal domain; Region: Couple_hipA; cl11853 754507004020 HipA-like N-terminal domain; Region: HipA_N; pfam07805 754507004021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754507004022 non-specific DNA binding site [nucleotide binding]; other site 754507004023 salt bridge; other site 754507004024 sequence-specific DNA binding site [nucleotide binding]; other site 754507004025 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 754507004026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507004027 putative substrate translocation pore; other site 754507004028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507004029 HlyD family secretion protein; Region: HlyD; pfam00529 754507004030 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754507004031 HlyD family secretion protein; Region: HlyD_3; pfam13437 754507004032 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 754507004033 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 754507004034 dimerization interface [polypeptide binding]; other site 754507004035 DPS ferroxidase diiron center [ion binding]; other site 754507004036 ion pore; other site 754507004037 exoribonuclease II; Provisional; Region: PRK05054 754507004038 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 754507004039 RNB domain; Region: RNB; pfam00773 754507004040 S1 RNA binding domain; Region: S1; pfam00575 754507004041 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 754507004042 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 754507004043 NAD binding site [chemical binding]; other site 754507004044 homotetramer interface [polypeptide binding]; other site 754507004045 homodimer interface [polypeptide binding]; other site 754507004046 substrate binding site [chemical binding]; other site 754507004047 active site 754507004048 Uncharacterized conserved protein [Function unknown]; Region: COG0327 754507004049 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 754507004050 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 754507004051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507004052 FeS/SAM binding site; other site 754507004053 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 754507004054 active site 754507004055 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 754507004056 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 754507004057 dimer interface [polypeptide binding]; other site 754507004058 putative anticodon binding site; other site 754507004059 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 754507004060 motif 1; other site 754507004061 active site 754507004062 motif 2; other site 754507004063 motif 3; other site 754507004064 peptide chain release factor 2; Provisional; Region: PRK08787 754507004065 This domain is found in peptide chain release factors; Region: PCRF; smart00937 754507004066 RF-1 domain; Region: RF-1; pfam00472 754507004067 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 754507004068 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 754507004069 dimerization domain [polypeptide binding]; other site 754507004070 dimer interface [polypeptide binding]; other site 754507004071 catalytic residues [active] 754507004072 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 754507004073 DHH family; Region: DHH; pfam01368 754507004074 DHHA1 domain; Region: DHHA1; pfam02272 754507004075 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 754507004076 catalytic residues [active] 754507004077 hinge region; other site 754507004078 alpha helical domain; other site 754507004079 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 754507004080 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 754507004081 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 754507004082 cobalt transport protein CbiM; Validated; Region: PRK06265 754507004083 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 754507004084 Cobalt transport protein; Region: CbiQ; cl00463 754507004085 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 754507004086 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 754507004087 Walker A/P-loop; other site 754507004088 ATP binding site [chemical binding]; other site 754507004089 Q-loop/lid; other site 754507004090 ABC transporter signature motif; other site 754507004091 Walker B; other site 754507004092 D-loop; other site 754507004093 H-loop/switch region; other site 754507004094 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 754507004095 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 754507004096 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 754507004097 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 754507004098 dimerization interface [polypeptide binding]; other site 754507004099 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 754507004100 ATP binding site [chemical binding]; other site 754507004101 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 754507004102 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 754507004103 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 754507004104 shikimate binding site; other site 754507004105 NAD(P) binding site [chemical binding]; other site 754507004106 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 754507004107 FAD binding site [chemical binding]; other site 754507004108 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 754507004109 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 754507004110 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 754507004111 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 754507004112 multifunctional aminopeptidase A; Provisional; Region: PRK00913 754507004113 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 754507004114 interface (dimer of trimers) [polypeptide binding]; other site 754507004115 Substrate-binding/catalytic site; other site 754507004116 Zn-binding sites [ion binding]; other site 754507004117 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 754507004118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507004119 Walker A/P-loop; other site 754507004120 ATP binding site [chemical binding]; other site 754507004121 Q-loop/lid; other site 754507004122 ABC transporter signature motif; other site 754507004123 Walker B; other site 754507004124 D-loop; other site 754507004125 H-loop/switch region; other site 754507004126 TOBE domain; Region: TOBE; pfam03459 754507004127 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 754507004128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507004129 dimer interface [polypeptide binding]; other site 754507004130 conserved gate region; other site 754507004131 putative PBP binding loops; other site 754507004132 ABC-ATPase subunit interface; other site 754507004133 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754507004134 molybdenum ABC transporter, periplasmic molybdate-binding protein; Region: modA; TIGR01256 754507004135 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 754507004136 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 754507004137 molybdenum-pterin binding domain; Region: Mop; TIGR00638 754507004138 TOBE domain; Region: TOBE; pfam03459 754507004139 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754507004140 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 754507004141 transmembrane helices; other site 754507004142 5'-nucleotidase; Provisional; Region: PRK03826 754507004143 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 754507004144 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754507004145 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754507004146 protein binding site [polypeptide binding]; other site 754507004147 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 754507004148 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 754507004149 catalytic motif [active] 754507004150 Zn binding site [ion binding]; other site 754507004151 RibD C-terminal domain; Region: RibD_C; cl17279 754507004152 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 754507004153 ATP cone domain; Region: ATP-cone; pfam03477 754507004154 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 754507004155 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 754507004156 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 754507004157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507004158 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 754507004159 dimerization interface [polypeptide binding]; other site 754507004160 substrate binding pocket [chemical binding]; other site 754507004161 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 754507004162 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 754507004163 homodimer interface [polypeptide binding]; other site 754507004164 substrate-cofactor binding pocket; other site 754507004165 catalytic residue [active] 754507004166 malate dehydrogenase; Provisional; Region: PRK05086 754507004167 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 754507004168 NAD binding site [chemical binding]; other site 754507004169 dimerization interface [polypeptide binding]; other site 754507004170 Substrate binding site [chemical binding]; other site 754507004171 arginine repressor; Provisional; Region: PRK05066 754507004172 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 754507004173 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 754507004174 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 754507004175 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 754507004176 putative NAD(P) binding site [chemical binding]; other site 754507004177 putative active site [active] 754507004178 electron transport complex protein RsxA; Provisional; Region: PRK05151 754507004179 electron transport complex protein RnfB; Provisional; Region: PRK05113 754507004180 Putative Fe-S cluster; Region: FeS; pfam04060 754507004181 4Fe-4S binding domain; Region: Fer4; pfam00037 754507004182 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 754507004183 SLBB domain; Region: SLBB; pfam10531 754507004184 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754507004185 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 754507004186 electron transport complex protein RnfG; Validated; Region: PRK01908 754507004187 electron transport complex RsxE subunit; Provisional; Region: PRK12405 754507004188 endonuclease III; Provisional; Region: PRK10702 754507004189 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 754507004190 minor groove reading motif; other site 754507004191 helix-hairpin-helix signature motif; other site 754507004192 substrate binding pocket [chemical binding]; other site 754507004193 active site 754507004194 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 754507004195 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 754507004196 Na2 binding site [ion binding]; other site 754507004197 putative substrate binding site 1 [chemical binding]; other site 754507004198 Na binding site 1 [ion binding]; other site 754507004199 putative substrate binding site 2 [chemical binding]; other site 754507004200 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754507004201 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507004202 ABC-ATPase subunit interface; other site 754507004203 dimer interface [polypeptide binding]; other site 754507004204 putative PBP binding regions; other site 754507004205 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 754507004206 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754507004207 putative peptidase; Provisional; Region: PRK11649 754507004208 Peptidase family M23; Region: Peptidase_M23; pfam01551 754507004209 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 754507004210 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754507004211 Walker A/P-loop; other site 754507004212 ATP binding site [chemical binding]; other site 754507004213 Q-loop/lid; other site 754507004214 ABC transporter signature motif; other site 754507004215 Walker B; other site 754507004216 D-loop; other site 754507004217 H-loop/switch region; other site 754507004218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507004219 ABC-ATPase subunit interface; other site 754507004220 dimer interface [polypeptide binding]; other site 754507004221 putative PBP binding regions; other site 754507004222 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754507004223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507004224 ABC-ATPase subunit interface; other site 754507004225 dimer interface [polypeptide binding]; other site 754507004226 putative PBP binding regions; other site 754507004227 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 754507004228 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754507004229 putative ligand binding residues [chemical binding]; other site 754507004230 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 754507004231 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 754507004232 active site 754507004233 metal binding site [ion binding]; metal-binding site 754507004234 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 754507004235 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 754507004236 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 754507004237 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 754507004238 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 754507004239 Putative phage tail protein; Region: Phage-tail_3; pfam13550 754507004240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 754507004241 DNA binding site [nucleotide binding] 754507004242 sensor protein QseC; Provisional; Region: PRK10337 754507004243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 754507004244 dimer interface [polypeptide binding]; other site 754507004245 phosphorylation site [posttranslational modification] 754507004246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507004247 ATP binding site [chemical binding]; other site 754507004248 Mg2+ binding site [ion binding]; other site 754507004249 G-X-G motif; other site 754507004250 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 754507004251 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 754507004252 argininosuccinate synthase; Validated; Region: PRK05370 754507004253 argininosuccinate synthase; Provisional; Region: PRK13820 754507004254 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 754507004255 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 754507004256 putative NAD(P) binding site [chemical binding]; other site 754507004257 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 754507004258 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 754507004259 G1 box; other site 754507004260 putative GEF interaction site [polypeptide binding]; other site 754507004261 GTP/Mg2+ binding site [chemical binding]; other site 754507004262 Switch I region; other site 754507004263 G2 box; other site 754507004264 G3 box; other site 754507004265 Switch II region; other site 754507004266 G4 box; other site 754507004267 G5 box; other site 754507004268 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 754507004269 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 754507004270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754507004271 non-specific DNA binding site [nucleotide binding]; other site 754507004272 salt bridge; other site 754507004273 sequence-specific DNA binding site [nucleotide binding]; other site 754507004274 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 754507004275 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754507004276 metal binding triad; other site 754507004277 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754507004278 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754507004279 metal binding triad; other site 754507004280 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754507004281 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 754507004282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754507004283 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 754507004284 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 754507004285 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 754507004286 AAA ATPase domain; Region: AAA_15; pfam13175 754507004287 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 754507004288 putative active site [active] 754507004289 putative metal-binding site [ion binding]; other site 754507004290 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 754507004291 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 754507004292 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 754507004293 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 754507004294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 754507004295 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 754507004296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507004297 dimer interface [polypeptide binding]; other site 754507004298 conserved gate region; other site 754507004299 putative PBP binding loops; other site 754507004300 ABC-ATPase subunit interface; other site 754507004301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507004302 dimer interface [polypeptide binding]; other site 754507004303 conserved gate region; other site 754507004304 putative PBP binding loops; other site 754507004305 ABC-ATPase subunit interface; other site 754507004306 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 754507004307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507004308 Walker A/P-loop; other site 754507004309 ATP binding site [chemical binding]; other site 754507004310 Q-loop/lid; other site 754507004311 ABC transporter signature motif; other site 754507004312 Walker B; other site 754507004313 D-loop; other site 754507004314 H-loop/switch region; other site 754507004315 biotin synthase; Region: bioB; TIGR00433 754507004316 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507004317 FeS/SAM binding site; other site 754507004318 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 754507004319 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 754507004320 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 754507004321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754507004322 protein binding site [polypeptide binding]; other site 754507004323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 754507004324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 754507004325 Protein of unknown function (DUF1043); Region: DUF1043; pfam06295 754507004326 uncharacterized domain; Region: TIGR00702 754507004327 YcaO-like family; Region: YcaO; pfam02624 754507004328 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 754507004329 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 754507004330 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 754507004331 Uncharacterized conserved protein [Function unknown]; Region: COG3422 754507004332 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 754507004333 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 754507004334 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 754507004335 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754507004336 active site turn [active] 754507004337 phosphorylation site [posttranslational modification] 754507004338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507004339 Methyltransferase domain; Region: Methyltransf_23; pfam13489 754507004340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 754507004341 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 754507004342 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 754507004343 tRNA; other site 754507004344 putative tRNA binding site [nucleotide binding]; other site 754507004345 putative NADP binding site [chemical binding]; other site 754507004346 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 754507004347 MarR family; Region: MarR_2; cl17246 754507004348 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754507004349 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754507004350 nucleotide binding site [chemical binding]; other site 754507004351 adenylate kinase; Reviewed; Region: adk; PRK00279 754507004352 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 754507004353 AMP-binding site [chemical binding]; other site 754507004354 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 754507004355 muropeptide transporter; Reviewed; Region: ampG; PRK11902 754507004356 AmpG-like permease; Region: 2A0125; TIGR00901 754507004357 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 754507004358 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 754507004359 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 754507004360 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 754507004361 NAD binding site [chemical binding]; other site 754507004362 homodimer interface [polypeptide binding]; other site 754507004363 active site 754507004364 substrate binding site [chemical binding]; other site 754507004365 Protein of unknown function (DUF805); Region: DUF805; pfam05656 754507004366 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 754507004367 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 754507004368 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 754507004369 Ligand Binding Site [chemical binding]; other site 754507004370 TilS substrate binding domain; Region: TilS; pfam09179 754507004371 TilS substrate C-terminal domain; Region: TilS_C; smart00977 754507004372 pyridoxamine kinase; Validated; Region: PRK05756 754507004373 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 754507004374 dimer interface [polypeptide binding]; other site 754507004375 pyridoxal binding site [chemical binding]; other site 754507004376 ATP binding site [chemical binding]; other site 754507004377 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 754507004378 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 754507004379 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 754507004380 active site 754507004381 homotetramer interface [polypeptide binding]; other site 754507004382 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 754507004383 BRO family, N-terminal domain; Region: Bro-N; smart01040 754507004384 P22AR C-terminal domain; Region: P22_AR_C; pfam10548 754507004385 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 754507004386 Helix-turn-helix domain; Region: HTH_39; pfam14090 754507004387 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 754507004388 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 754507004389 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 754507004390 YcfA-like protein; Region: YcfA; pfam07927 754507004391 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 754507004392 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 754507004393 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 754507004394 GMP synthase; Reviewed; Region: guaA; PRK00074 754507004395 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 754507004396 AMP/PPi binding site [chemical binding]; other site 754507004397 candidate oxyanion hole; other site 754507004398 catalytic triad [active] 754507004399 potential glutamine specificity residues [chemical binding]; other site 754507004400 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 754507004401 ATP Binding subdomain [chemical binding]; other site 754507004402 Ligand Binding sites [chemical binding]; other site 754507004403 Dimerization subdomain; other site 754507004404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 754507004405 RelB antitoxin; Region: RelB; cl01171 754507004406 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 754507004407 ribosome maturation protein RimP; Reviewed; Region: PRK00092 754507004408 hypothetical protein; Provisional; Region: PRK14641 754507004409 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 754507004410 putative oligomer interface [polypeptide binding]; other site 754507004411 putative RNA binding site [nucleotide binding]; other site 754507004412 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 754507004413 NusA N-terminal domain; Region: NusA_N; pfam08529 754507004414 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 754507004415 RNA binding site [nucleotide binding]; other site 754507004416 homodimer interface [polypeptide binding]; other site 754507004417 NusA-like KH domain; Region: KH_5; pfam13184 754507004418 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 754507004419 G-X-X-G motif; other site 754507004420 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 754507004421 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 754507004422 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 754507004423 translation initiation factor IF-2; Region: IF-2; TIGR00487 754507004424 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 754507004425 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 754507004426 G1 box; other site 754507004427 putative GEF interaction site [polypeptide binding]; other site 754507004428 GTP/Mg2+ binding site [chemical binding]; other site 754507004429 Switch I region; other site 754507004430 G2 box; other site 754507004431 G3 box; other site 754507004432 Switch II region; other site 754507004433 G4 box; other site 754507004434 G5 box; other site 754507004435 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 754507004436 Translation-initiation factor 2; Region: IF-2; pfam11987 754507004437 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 754507004438 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 754507004439 DNA methylase; Region: N6_N4_Mtase; cl17433 754507004440 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 754507004441 ATP binding site [chemical binding]; other site 754507004442 putative Mg++ binding site [ion binding]; other site 754507004443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507004444 ATP binding site [chemical binding]; other site 754507004445 putative Mg++ binding site [ion binding]; other site 754507004446 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 754507004447 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 754507004448 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 754507004449 RNA binding site [nucleotide binding]; other site 754507004450 active site 754507004451 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 754507004452 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 754507004453 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 754507004454 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 754507004455 active site 754507004456 HIGH motif; other site 754507004457 dimer interface [polypeptide binding]; other site 754507004458 KMSKS motif; other site 754507004459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507004460 RNA binding surface [nucleotide binding]; other site 754507004461 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 754507004462 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 754507004463 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 754507004464 ligand binding site [chemical binding]; other site 754507004465 homodimer interface [polypeptide binding]; other site 754507004466 NAD(P) binding site [chemical binding]; other site 754507004467 trimer interface B [polypeptide binding]; other site 754507004468 trimer interface A [polypeptide binding]; other site 754507004469 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 754507004470 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 754507004471 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 754507004472 Fic family protein [Function unknown]; Region: COG3177 754507004473 Fic/DOC family; Region: Fic; pfam02661 754507004474 selenophosphate synthetase; Provisional; Region: PRK00943 754507004475 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 754507004476 dimerization interface [polypeptide binding]; other site 754507004477 putative ATP binding site [chemical binding]; other site 754507004478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507004479 ABC transporter; Region: ABC_tran; pfam00005 754507004480 Q-loop/lid; other site 754507004481 ABC transporter signature motif; other site 754507004482 Walker B; other site 754507004483 D-loop; other site 754507004484 H-loop/switch region; other site 754507004485 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754507004486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507004487 dimer interface [polypeptide binding]; other site 754507004488 conserved gate region; other site 754507004489 putative PBP binding loops; other site 754507004490 ABC-ATPase subunit interface; other site 754507004491 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754507004492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507004493 dimer interface [polypeptide binding]; other site 754507004494 conserved gate region; other site 754507004495 putative PBP binding loops; other site 754507004496 ABC-ATPase subunit interface; other site 754507004497 hypothetical protein; Provisional; Region: PRK11622 754507004498 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 754507004499 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 754507004500 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 754507004501 GIY-YIG motif/motif A; other site 754507004502 active site 754507004503 catalytic site [active] 754507004504 putative DNA binding site [nucleotide binding]; other site 754507004505 metal binding site [ion binding]; metal-binding site 754507004506 UvrB/uvrC motif; Region: UVR; pfam02151 754507004507 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 754507004508 Helix-hairpin-helix motif; Region: HHH; pfam00633 754507004509 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 754507004510 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 754507004511 Ligand binding site; other site 754507004512 oligomer interface; other site 754507004513 Uncharacterized conserved protein [Function unknown]; Region: COG2835 754507004514 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 754507004515 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 754507004516 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 754507004517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754507004518 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 754507004519 Walker A/P-loop; other site 754507004520 ATP binding site [chemical binding]; other site 754507004521 Q-loop/lid; other site 754507004522 ABC transporter signature motif; other site 754507004523 Walker B; other site 754507004524 D-loop; other site 754507004525 H-loop/switch region; other site 754507004526 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 754507004527 Competence protein; Region: Competence; pfam03772 754507004528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 754507004529 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 754507004530 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 754507004531 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 754507004532 active site 754507004533 NTP binding site [chemical binding]; other site 754507004534 metal binding triad [ion binding]; metal-binding site 754507004535 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 754507004536 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 754507004537 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 754507004538 catalytic center binding site [active] 754507004539 ATP binding site [chemical binding]; other site 754507004540 phosphate acetyltransferase; Reviewed; Region: PRK05632 754507004541 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 754507004542 DRTGG domain; Region: DRTGG; pfam07085 754507004543 phosphate acetyltransferase; Region: pta; TIGR00651 754507004544 propionate/acetate kinase; Provisional; Region: PRK12379 754507004545 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 754507004546 hypothetical protein; Provisional; Region: PRK01816 754507004547 Colicin V production protein; Region: Colicin_V; cl00567 754507004548 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 754507004549 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 754507004550 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 754507004551 maltodextrin phosphorylase; Provisional; Region: PRK14985 754507004552 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 754507004553 active site pocket [active] 754507004554 transcriptional regulator MalT; Provisional; Region: PRK04841 754507004555 AAA ATPase domain; Region: AAA_16; pfam13191 754507004556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 754507004557 DNA binding residues [nucleotide binding] 754507004558 dimerization interface [polypeptide binding]; other site 754507004559 tellurite resistance protein TehB; Provisional; Region: PRK12335 754507004560 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 754507004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507004562 S-adenosylmethionine binding site [chemical binding]; other site 754507004563 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 754507004564 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 754507004565 dimer interface [polypeptide binding]; other site 754507004566 TPP-binding site [chemical binding]; other site 754507004567 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 754507004568 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754507004569 E3 interaction surface; other site 754507004570 lipoyl attachment site [posttranslational modification]; other site 754507004571 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754507004572 E3 interaction surface; other site 754507004573 lipoyl attachment site [posttranslational modification]; other site 754507004574 e3 binding domain; Region: E3_binding; pfam02817 754507004575 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754507004576 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 754507004577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754507004578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754507004579 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 754507004580 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 754507004581 putative FMN binding site [chemical binding]; other site 754507004582 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 754507004583 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 754507004584 tandem repeat interface [polypeptide binding]; other site 754507004585 oligomer interface [polypeptide binding]; other site 754507004586 active site residues [active] 754507004587 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 754507004588 tandem repeat interface [polypeptide binding]; other site 754507004589 oligomer interface [polypeptide binding]; other site 754507004590 active site residues [active] 754507004591 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 754507004592 Chorismate mutase type II; Region: CM_2; cl00693 754507004593 prephenate dehydrogenase; Validated; Region: PRK08507 754507004594 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 754507004595 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 754507004596 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 754507004597 RNA binding surface [nucleotide binding]; other site 754507004598 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 754507004599 probable active site [active] 754507004600 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 754507004601 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507004602 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 754507004603 substrate binding site [chemical binding]; other site 754507004604 dimerization interface [polypeptide binding]; other site 754507004605 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 754507004606 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 754507004607 trimer interface [polypeptide binding]; other site 754507004608 active site 754507004609 substrate binding site [chemical binding]; other site 754507004610 CoA binding site [chemical binding]; other site 754507004611 dsDNA-mimic protein; Reviewed; Region: PRK05094 754507004612 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 754507004613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754507004614 DNA binding site [nucleotide binding] 754507004615 domain linker motif; other site 754507004616 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 754507004617 dimerization interface [polypeptide binding]; other site 754507004618 ligand binding site [chemical binding]; other site 754507004619 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 754507004620 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 754507004621 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754507004622 putative active site [active] 754507004623 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 754507004624 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754507004625 DNA binding site [nucleotide binding] 754507004626 domain linker motif; other site 754507004627 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 754507004628 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 754507004629 catalytic residues [active] 754507004630 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 754507004631 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 754507004632 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 754507004633 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 754507004634 SelR domain; Region: SelR; pfam01641 754507004635 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 754507004636 active site clefts [active] 754507004637 zinc binding site [ion binding]; other site 754507004638 dimer interface [polypeptide binding]; other site 754507004639 outer membrane lipoprotein; Provisional; Region: PRK11023 754507004640 BON domain; Region: BON; pfam04972 754507004641 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 754507004642 dimer interface [polypeptide binding]; other site 754507004643 active site 754507004644 hypothetical protein; Reviewed; Region: PRK12497 754507004645 LppC putative lipoprotein; Region: LppC; pfam04348 754507004646 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 754507004647 putative ligand binding site [chemical binding]; other site 754507004648 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 754507004649 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 754507004650 putative SAM binding site [chemical binding]; other site 754507004651 putative homodimer interface [polypeptide binding]; other site 754507004652 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 754507004653 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 754507004654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754507004655 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 754507004656 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754507004657 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 754507004658 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 754507004659 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 754507004660 tandem repeat interface [polypeptide binding]; other site 754507004661 oligomer interface [polypeptide binding]; other site 754507004662 active site residues [active] 754507004663 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 754507004664 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 754507004665 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 754507004666 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754507004667 ligand binding site [chemical binding]; other site 754507004668 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 754507004669 Phosphotransferase enzyme family; Region: APH; pfam01636 754507004670 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 754507004671 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 754507004672 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 754507004673 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 754507004674 active site 754507004675 dimer interface [polypeptide binding]; other site 754507004676 motif 1; other site 754507004677 motif 2; other site 754507004678 motif 3; other site 754507004679 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 754507004680 anticodon binding site; other site 754507004681 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 754507004682 ferredoxin-NADP reductase; Provisional; Region: PRK10926 754507004683 FAD binding pocket [chemical binding]; other site 754507004684 FAD binding motif [chemical binding]; other site 754507004685 phosphate binding motif [ion binding]; other site 754507004686 beta-alpha-beta structure motif; other site 754507004687 NAD binding pocket [chemical binding]; other site 754507004688 translation initiation factor IF-3; Region: infC; TIGR00168 754507004689 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 754507004690 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 754507004691 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 754507004692 23S rRNA binding site [nucleotide binding]; other site 754507004693 L21 binding site [polypeptide binding]; other site 754507004694 L13 binding site [polypeptide binding]; other site 754507004695 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 754507004696 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Region: agaZ_gatZ; TIGR02810 754507004697 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754507004698 active site 754507004699 phosphorylation site [posttranslational modification] 754507004700 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 754507004701 active site 754507004702 P-loop; other site 754507004703 phosphorylation site [posttranslational modification] 754507004704 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 754507004705 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754507004706 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 754507004707 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 754507004708 putative NAD(P) binding site [chemical binding]; other site 754507004709 catalytic Zn binding site [ion binding]; other site 754507004710 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 754507004711 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 754507004712 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 754507004713 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 754507004714 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 754507004715 TPP-binding site; other site 754507004716 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754507004717 PYR/PP interface [polypeptide binding]; other site 754507004718 dimer interface [polypeptide binding]; other site 754507004719 TPP binding site [chemical binding]; other site 754507004720 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754507004721 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 754507004722 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 754507004723 substrate binding pocket [chemical binding]; other site 754507004724 chain length determination region; other site 754507004725 substrate-Mg2+ binding site; other site 754507004726 catalytic residues [active] 754507004727 aspartate-rich region 1; other site 754507004728 active site lid residues [active] 754507004729 aspartate-rich region 2; other site 754507004730 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 754507004731 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 754507004732 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 754507004733 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 754507004734 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 754507004735 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 754507004736 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 754507004737 catalytic core [active] 754507004738 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 754507004739 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 754507004740 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 754507004741 putative active site [active] 754507004742 catalytic site [active] 754507004743 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 754507004744 putative active site [active] 754507004745 catalytic site [active] 754507004746 Predicted membrane protein [Function unknown]; Region: COG2431 754507004747 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754507004748 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 754507004749 active site 754507004750 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 754507004751 EamA-like transporter family; Region: EamA; pfam00892 754507004752 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 754507004753 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 754507004754 PhnA protein; Region: PhnA; pfam03831 754507004755 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 754507004756 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 754507004757 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 754507004758 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754507004759 Walker A/P-loop; other site 754507004760 ATP binding site [chemical binding]; other site 754507004761 Q-loop/lid; other site 754507004762 ABC transporter signature motif; other site 754507004763 Walker B; other site 754507004764 D-loop; other site 754507004765 H-loop/switch region; other site 754507004766 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754507004767 FtsX-like permease family; Region: FtsX; pfam02687 754507004768 macrolide transporter subunit MacA; Provisional; Region: PRK11578 754507004769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754507004770 HlyD family secretion protein; Region: HlyD_3; pfam13437 754507004771 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 754507004772 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 754507004773 active site 754507004774 HIGH motif; other site 754507004775 nucleotide binding site [chemical binding]; other site 754507004776 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 754507004777 KMSKS motif; other site 754507004778 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 754507004779 hypothetical protein; Provisional; Region: PRK05170 754507004780 glycogen branching enzyme; Provisional; Region: PRK05402 754507004781 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 754507004782 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 754507004783 active site 754507004784 catalytic site [active] 754507004785 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 754507004786 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 754507004787 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 754507004788 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 754507004789 active site 754507004790 catalytic site [active] 754507004791 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 754507004792 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 754507004793 ligand binding site; other site 754507004794 oligomer interface; other site 754507004795 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 754507004796 N-terminal domain interface [polypeptide binding]; other site 754507004797 sulfate 1 binding site; other site 754507004798 glycogen synthase; Provisional; Region: glgA; PRK00654 754507004799 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 754507004800 ADP-binding pocket [chemical binding]; other site 754507004801 homodimer interface [polypeptide binding]; other site 754507004802 glycogen phosphorylase; Provisional; Region: PRK14986 754507004803 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 754507004804 homodimer interface [polypeptide binding]; other site 754507004805 active site pocket [active] 754507004806 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 754507004807 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 754507004808 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 754507004809 5S rRNA interface [nucleotide binding]; other site 754507004810 CTC domain interface [polypeptide binding]; other site 754507004811 L16 interface [polypeptide binding]; other site 754507004812 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 754507004813 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 754507004814 condesin subunit F; Provisional; Region: PRK05260 754507004815 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 754507004816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507004817 putative substrate translocation pore; other site 754507004818 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 754507004819 putative acyl-acceptor binding pocket; other site 754507004820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754507004821 acyl-activating enzyme (AAE) consensus motif; other site 754507004822 AMP binding site [chemical binding]; other site 754507004823 active site 754507004824 CoA binding site [chemical binding]; other site 754507004825 condesin subunit E; Provisional; Region: PRK05256 754507004826 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 754507004827 P-loop containing region of AAA domain; Region: AAA_29; cl17516 754507004828 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 754507004829 exonuclease I; Provisional; Region: sbcB; PRK11779 754507004830 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 754507004831 active site 754507004832 substrate binding site [chemical binding]; other site 754507004833 catalytic site [active] 754507004834 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 754507004835 HTH-like domain; Region: HTH_21; pfam13276 754507004836 Integrase core domain; Region: rve; pfam00665 754507004837 Integrase core domain; Region: rve_2; pfam13333 754507004838 Phage X family; Region: Phage_X; cl11585 754507004839 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 754507004840 Ferritin-like domain; Region: Ferritin; pfam00210 754507004841 ferroxidase diiron center [ion binding]; other site 754507004842 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 754507004843 Ferritin-like domain; Region: Ferritin; pfam00210 754507004844 ferroxidase diiron center [ion binding]; other site 754507004845 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 754507004846 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 754507004847 ligand binding site [chemical binding]; other site 754507004848 flexible hinge region; other site 754507004849 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 754507004850 putative switch regulator; other site 754507004851 non-specific DNA interactions [nucleotide binding]; other site 754507004852 DNA binding site [nucleotide binding] 754507004853 sequence specific DNA binding site [nucleotide binding]; other site 754507004854 putative cAMP binding site [chemical binding]; other site 754507004855 universal stress protein UspE; Provisional; Region: PRK11175 754507004856 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754507004857 Ligand Binding Site [chemical binding]; other site 754507004858 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 754507004859 Ligand Binding Site [chemical binding]; other site 754507004860 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 754507004861 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 754507004862 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 754507004863 active site 754507004864 interdomain interaction site; other site 754507004865 putative metal-binding site [ion binding]; other site 754507004866 nucleotide binding site [chemical binding]; other site 754507004867 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 754507004868 domain I; other site 754507004869 DNA binding groove [nucleotide binding] 754507004870 phosphate binding site [ion binding]; other site 754507004871 domain II; other site 754507004872 domain III; other site 754507004873 nucleotide binding site [chemical binding]; other site 754507004874 catalytic site [active] 754507004875 domain IV; other site 754507004876 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754507004877 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 754507004878 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 754507004879 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 754507004880 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 754507004881 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 754507004882 active site 754507004883 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 754507004884 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 754507004885 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 754507004886 quinone interaction residues [chemical binding]; other site 754507004887 active site 754507004888 catalytic residues [active] 754507004889 FMN binding site [chemical binding]; other site 754507004890 substrate binding site [chemical binding]; other site 754507004891 aminopeptidase N; Provisional; Region: pepN; PRK14015 754507004892 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 754507004893 active site 754507004894 Zn binding site [ion binding]; other site 754507004895 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 754507004896 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754507004897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507004898 homodimer interface [polypeptide binding]; other site 754507004899 catalytic residue [active] 754507004900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 754507004901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 754507004902 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 754507004903 HlyD family secretion protein; Region: HlyD_3; pfam13437 754507004904 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 754507004905 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 754507004906 Walker A/P-loop; other site 754507004907 ATP binding site [chemical binding]; other site 754507004908 Q-loop/lid; other site 754507004909 ABC transporter signature motif; other site 754507004910 Walker B; other site 754507004911 D-loop; other site 754507004912 H-loop/switch region; other site 754507004913 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 754507004914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507004915 Walker A/P-loop; other site 754507004916 ATP binding site [chemical binding]; other site 754507004917 Q-loop/lid; other site 754507004918 ABC transporter signature motif; other site 754507004919 Walker B; other site 754507004920 D-loop; other site 754507004921 H-loop/switch region; other site 754507004922 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754507004923 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754507004924 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 754507004925 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 754507004926 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754507004927 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 754507004928 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 754507004929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507004930 ABC-ATPase subunit interface; other site 754507004931 dimer interface [polypeptide binding]; other site 754507004932 putative PBP binding regions; other site 754507004933 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 754507004934 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 754507004935 Walker A/P-loop; other site 754507004936 ATP binding site [chemical binding]; other site 754507004937 Q-loop/lid; other site 754507004938 ABC transporter signature motif; other site 754507004939 Walker B; other site 754507004940 D-loop; other site 754507004941 H-loop/switch region; other site 754507004942 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 754507004943 putative ligand binding residues [chemical binding]; other site 754507004944 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754507004945 molybdenum-pterin binding domain; Region: Mop; TIGR00638 754507004946 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754507004947 ligand-binding site [chemical binding]; other site 754507004948 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754507004949 N-terminal plug; other site 754507004950 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 754507004951 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754507004952 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 754507004953 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507004954 ABC-ATPase subunit interface; other site 754507004955 dimer interface [polypeptide binding]; other site 754507004956 putative PBP binding regions; other site 754507004957 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 754507004958 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 754507004959 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754507004960 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 754507004961 ligand-binding site [chemical binding]; other site 754507004962 DoxX; Region: DoxX; pfam07681 754507004963 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 754507004964 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 754507004965 Ligand Binding Site [chemical binding]; other site 754507004966 NlpC/P60 family; Region: NLPC_P60; pfam00877 754507004967 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754507004968 IHF dimer interface [polypeptide binding]; other site 754507004969 IHF - DNA interface [nucleotide binding]; other site 754507004970 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 754507004971 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 754507004972 putative tRNA-binding site [nucleotide binding]; other site 754507004973 B3/4 domain; Region: B3_4; pfam03483 754507004974 tRNA synthetase B5 domain; Region: B5; smart00874 754507004975 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 754507004976 dimer interface [polypeptide binding]; other site 754507004977 motif 1; other site 754507004978 motif 3; other site 754507004979 motif 2; other site 754507004980 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 754507004981 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 754507004982 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 754507004983 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 754507004984 dimer interface [polypeptide binding]; other site 754507004985 motif 1; other site 754507004986 active site 754507004987 motif 2; other site 754507004988 motif 3; other site 754507004989 heat shock protein HtpX; Provisional; Region: PRK05457 754507004990 KpsF/GutQ family protein; Region: kpsF; TIGR00393 754507004991 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 754507004992 putative active site [active] 754507004993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 754507004994 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 754507004995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507004996 active site 754507004997 motif I; other site 754507004998 motif II; other site 754507004999 anthranilate synthase component I; Provisional; Region: PRK13564 754507005000 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 754507005001 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 754507005002 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 754507005003 Glutamine amidotransferase class-I; Region: GATase; pfam00117 754507005004 glutamine binding [chemical binding]; other site 754507005005 catalytic triad [active] 754507005006 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 754507005007 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 754507005008 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 754507005009 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 754507005010 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 754507005011 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 754507005012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 754507005013 non-specific DNA binding site [nucleotide binding]; other site 754507005014 salt bridge; other site 754507005015 sequence-specific DNA binding site [nucleotide binding]; other site 754507005016 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 754507005017 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 754507005018 active site 754507005019 ribulose/triose binding site [chemical binding]; other site 754507005020 phosphate binding site [ion binding]; other site 754507005021 substrate (anthranilate) binding pocket [chemical binding]; other site 754507005022 product (indole) binding pocket [chemical binding]; other site 754507005023 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 754507005024 active site 754507005025 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 754507005026 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 754507005027 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 754507005028 oxaloacetate decarboxylase; Provisional; Region: PRK14040 754507005029 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 754507005030 active site 754507005031 catalytic residues [active] 754507005032 metal binding site [ion binding]; metal-binding site 754507005033 homodimer binding site [polypeptide binding]; other site 754507005034 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 754507005035 carboxyltransferase (CT) interaction site; other site 754507005036 biotinylation site [posttranslational modification]; other site 754507005037 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 754507005038 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 754507005039 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754507005040 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 754507005041 ligand-binding site [chemical binding]; other site 754507005042 malonic semialdehyde reductase; Provisional; Region: PRK10538 754507005043 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 754507005044 putative NAD(P) binding site [chemical binding]; other site 754507005045 homotetramer interface [polypeptide binding]; other site 754507005046 homodimer interface [polypeptide binding]; other site 754507005047 active site 754507005048 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 754507005049 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 754507005050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507005051 catalytic residue [active] 754507005052 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 754507005053 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 754507005054 substrate binding site [chemical binding]; other site 754507005055 active site 754507005056 catalytic residues [active] 754507005057 heterodimer interface [polypeptide binding]; other site 754507005058 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 754507005059 Class I ribonucleotide reductase; Region: RNR_I; cd01679 754507005060 active site 754507005061 dimer interface [polypeptide binding]; other site 754507005062 catalytic residues [active] 754507005063 effector binding site; other site 754507005064 R2 peptide binding site; other site 754507005065 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 754507005066 dimer interface [polypeptide binding]; other site 754507005067 putative radical transfer pathway; other site 754507005068 diiron center [ion binding]; other site 754507005069 tyrosyl radical; other site 754507005070 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 754507005071 pyruvate kinase; Provisional; Region: PRK05826 754507005072 active site 754507005073 domain interfaces; other site 754507005074 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 754507005075 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 754507005076 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 754507005077 putative active site; other site 754507005078 catalytic residue [active] 754507005079 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 754507005080 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 754507005081 ligand binding site [chemical binding]; other site 754507005082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507005083 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507005084 TM-ABC transporter signature motif; other site 754507005085 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507005086 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507005087 TM-ABC transporter signature motif; other site 754507005088 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 754507005089 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754507005090 Walker A/P-loop; other site 754507005091 ATP binding site [chemical binding]; other site 754507005092 Q-loop/lid; other site 754507005093 ABC transporter signature motif; other site 754507005094 Walker B; other site 754507005095 D-loop; other site 754507005096 H-loop/switch region; other site 754507005097 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754507005098 transcriptional regulator LsrR; Provisional; Region: PRK15418 754507005099 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 754507005100 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 754507005101 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 754507005102 putative N- and C-terminal domain interface [polypeptide binding]; other site 754507005103 putative active site [active] 754507005104 putative MgATP binding site [chemical binding]; other site 754507005105 catalytic site [active] 754507005106 metal binding site [ion binding]; metal-binding site 754507005107 putative carbohydrate binding site [chemical binding]; other site 754507005108 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 754507005109 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 754507005110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 754507005111 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 754507005112 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 754507005113 putative dimer interface [polypeptide binding]; other site 754507005114 putative anticodon binding site; other site 754507005115 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 754507005116 homodimer interface [polypeptide binding]; other site 754507005117 motif 1; other site 754507005118 motif 2; other site 754507005119 active site 754507005120 motif 3; other site 754507005121 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 754507005122 stringent starvation protein A; Provisional; Region: sspA; PRK09481 754507005123 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 754507005124 C-terminal domain interface [polypeptide binding]; other site 754507005125 putative GSH binding site (G-site) [chemical binding]; other site 754507005126 dimer interface [polypeptide binding]; other site 754507005127 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 754507005128 dimer interface [polypeptide binding]; other site 754507005129 N-terminal domain interface [polypeptide binding]; other site 754507005130 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 754507005131 MoaE homodimer interface [polypeptide binding]; other site 754507005132 MoaD interaction [polypeptide binding]; other site 754507005133 active site residues [active] 754507005134 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 754507005135 MoaE interaction surface [polypeptide binding]; other site 754507005136 MoeB interaction surface [polypeptide binding]; other site 754507005137 thiocarboxylated glycine; other site 754507005138 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 754507005139 trimer interface [polypeptide binding]; other site 754507005140 dimer interface [polypeptide binding]; other site 754507005141 putative active site [active] 754507005142 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 754507005143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507005144 FeS/SAM binding site; other site 754507005145 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 754507005146 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 754507005147 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 754507005148 phosphate binding site [ion binding]; other site 754507005149 putative substrate binding pocket [chemical binding]; other site 754507005150 dimer interface [polypeptide binding]; other site 754507005151 Fic/DOC family; Region: Fic; pfam02661 754507005152 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 754507005153 active site pocket [active] 754507005154 oxyanion hole [active] 754507005155 catalytic triad [active] 754507005156 active site nucleophile [active] 754507005157 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 754507005158 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 754507005159 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 754507005160 Ligand Binding Site [chemical binding]; other site 754507005161 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 754507005162 active site residue [active] 754507005163 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 754507005164 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 754507005165 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 754507005166 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 754507005167 molybdopterin cofactor binding site [chemical binding]; other site 754507005168 substrate binding site [chemical binding]; other site 754507005169 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 754507005170 molybdopterin cofactor binding site; other site 754507005171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 754507005172 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 754507005173 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 754507005174 transmembrane helices; other site 754507005175 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 754507005176 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 754507005177 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 754507005178 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 754507005179 dimerization interface 3.5A [polypeptide binding]; other site 754507005180 active site 754507005181 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 754507005182 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 754507005183 23S rRNA interface [nucleotide binding]; other site 754507005184 L3 interface [polypeptide binding]; other site 754507005185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507005186 S-adenosylmethionine binding site [chemical binding]; other site 754507005187 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 754507005188 AAA domain; Region: AAA_30; pfam13604 754507005189 Family description; Region: UvrD_C_2; pfam13538 754507005190 DsrE/DsrF-like family; Region: DrsE; cl00672 754507005191 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 754507005192 active site 1 [active] 754507005193 dimer interface [polypeptide binding]; other site 754507005194 active site 2 [active] 754507005195 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 754507005196 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 754507005197 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 754507005198 DNA-binding site [nucleotide binding]; DNA binding site 754507005199 RNA-binding motif; other site 754507005200 hypothetical protein; Provisional; Region: PRK05114 754507005201 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 754507005202 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 754507005203 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 754507005204 probable active site [active] 754507005205 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 754507005206 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 754507005207 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 754507005208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 754507005209 active site 754507005210 phosphorylation site [posttranslational modification] 754507005211 intermolecular recognition site; other site 754507005212 dimerization interface [polypeptide binding]; other site 754507005213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 754507005214 Walker A motif; other site 754507005215 ATP binding site [chemical binding]; other site 754507005216 Walker B motif; other site 754507005217 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 754507005218 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 754507005219 HAMP domain; Region: HAMP; pfam00672 754507005220 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 754507005221 Mg2+ binding site [ion binding]; other site 754507005222 G-X-G motif; other site 754507005223 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754507005224 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754507005225 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 754507005226 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 754507005227 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754507005228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507005229 Walker A/P-loop; other site 754507005230 ATP binding site [chemical binding]; other site 754507005231 Q-loop/lid; other site 754507005232 ABC transporter signature motif; other site 754507005233 Walker B; other site 754507005234 D-loop; other site 754507005235 H-loop/switch region; other site 754507005236 TOBE domain; Region: TOBE_2; pfam08402 754507005237 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 754507005238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507005239 dimer interface [polypeptide binding]; other site 754507005240 conserved gate region; other site 754507005241 putative PBP binding loops; other site 754507005242 ABC-ATPase subunit interface; other site 754507005243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507005244 dimer interface [polypeptide binding]; other site 754507005245 conserved gate region; other site 754507005246 putative PBP binding loops; other site 754507005247 ABC-ATPase subunit interface; other site 754507005248 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 754507005249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507005250 Walker A/P-loop; other site 754507005251 ATP binding site [chemical binding]; other site 754507005252 Q-loop/lid; other site 754507005253 ABC transporter signature motif; other site 754507005254 Walker B; other site 754507005255 D-loop; other site 754507005256 H-loop/switch region; other site 754507005257 TOBE domain; Region: TOBE_2; pfam08402 754507005258 Protein of unknown function, DUF462; Region: DUF462; cl01190 754507005259 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 754507005260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507005261 Walker A motif; other site 754507005262 ATP binding site [chemical binding]; other site 754507005263 Walker B motif; other site 754507005264 arginine finger; other site 754507005265 Peptidase family M41; Region: Peptidase_M41; pfam01434 754507005266 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 754507005267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507005268 S-adenosylmethionine binding site [chemical binding]; other site 754507005269 formyltetrahydrofolate deformylase; Region: PurU; TIGR00655 754507005270 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754507005271 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 754507005272 putative active site [active] 754507005273 putative substrate binding site [chemical binding]; other site 754507005274 putative cosubstrate binding site; other site 754507005275 catalytic site [active] 754507005276 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 754507005277 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 754507005278 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 754507005279 glutamate racemase; Provisional; Region: PRK00865 754507005280 Chorismate lyase; Region: Chor_lyase; cl01230 754507005281 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 754507005282 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 754507005283 generic binding surface II; other site 754507005284 ssDNA binding site; other site 754507005285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507005286 ATP binding site [chemical binding]; other site 754507005287 putative Mg++ binding site [ion binding]; other site 754507005288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507005289 nucleotide binding region [chemical binding]; other site 754507005290 ATP-binding site [chemical binding]; other site 754507005291 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 754507005292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754507005293 Zn2+ binding site [ion binding]; other site 754507005294 Mg2+ binding site [ion binding]; other site 754507005295 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 754507005296 synthetase active site [active] 754507005297 NTP binding site [chemical binding]; other site 754507005298 metal binding site [ion binding]; metal-binding site 754507005299 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 754507005300 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 754507005301 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 754507005302 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 754507005303 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 754507005304 catalytic site [active] 754507005305 G-X2-G-X-G-K; other site 754507005306 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 754507005307 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 754507005308 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 754507005309 Predicted membrane protein [Function unknown]; Region: COG2510 754507005310 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 754507005311 putative coenzyme Q binding site [chemical binding]; other site 754507005312 hypothetical protein; Validated; Region: PRK01777 754507005313 Uncharacterized conserved protein [Function unknown]; Region: COG2850 754507005314 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 754507005315 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 754507005316 generic binding surface II; other site 754507005317 generic binding surface I; other site 754507005318 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 754507005319 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754507005320 active site 754507005321 phosphorylation site [posttranslational modification] 754507005322 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 754507005323 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 754507005324 Walker A/P-loop; other site 754507005325 ATP binding site [chemical binding]; other site 754507005326 Q-loop/lid; other site 754507005327 ABC transporter signature motif; other site 754507005328 Walker B; other site 754507005329 D-loop; other site 754507005330 H-loop/switch region; other site 754507005331 OstA-like protein; Region: OstA; cl00844 754507005332 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 754507005333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 754507005334 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 754507005335 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 754507005336 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 754507005337 Walker A/P-loop; other site 754507005338 ATP binding site [chemical binding]; other site 754507005339 Q-loop/lid; other site 754507005340 ABC transporter signature motif; other site 754507005341 Walker B; other site 754507005342 D-loop; other site 754507005343 H-loop/switch region; other site 754507005344 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 754507005345 conserved hypothetical integral membrane protein; Region: TIGR00056 754507005346 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 754507005347 mce related protein; Region: MCE; pfam02470 754507005348 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 754507005349 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 754507005350 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 754507005351 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 754507005352 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 754507005353 hinge; other site 754507005354 active site 754507005355 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 754507005356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507005357 Walker A/P-loop; other site 754507005358 ATP binding site [chemical binding]; other site 754507005359 Q-loop/lid; other site 754507005360 ABC transporter signature motif; other site 754507005361 Walker B; other site 754507005362 D-loop; other site 754507005363 H-loop/switch region; other site 754507005364 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754507005365 active site 754507005366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 754507005367 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 754507005368 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 754507005369 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 754507005370 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 754507005371 DNA binding site [nucleotide binding] 754507005372 active site 754507005373 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 754507005374 putative DNA-binding cleft [nucleotide binding]; other site 754507005375 putative DNA clevage site; other site 754507005376 molecular lever; other site 754507005377 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 754507005378 HTH-like domain; Region: HTH_21; pfam13276 754507005379 Integrase core domain; Region: rve; pfam00665 754507005380 Integrase core domain; Region: rve_2; pfam13333 754507005381 glutamine synthetase; Provisional; Region: glnA; PRK09469 754507005382 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754507005383 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 754507005384 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 754507005385 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 754507005386 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 754507005387 G1 box; other site 754507005388 putative GEF interaction site [polypeptide binding]; other site 754507005389 GTP/Mg2+ binding site [chemical binding]; other site 754507005390 Switch I region; other site 754507005391 G2 box; other site 754507005392 G3 box; other site 754507005393 Switch II region; other site 754507005394 G4 box; other site 754507005395 G5 box; other site 754507005396 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 754507005397 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 754507005398 Autotransporter beta-domain; Region: Autotransporter; pfam03797 754507005399 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 754507005400 catalytic triad [active] 754507005401 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 754507005402 dihydrodipicolinate synthase; Region: dapA; TIGR00674 754507005403 dimer interface [polypeptide binding]; other site 754507005404 active site 754507005405 catalytic residue [active] 754507005406 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 754507005407 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 754507005408 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 754507005409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507005410 dimer interface [polypeptide binding]; other site 754507005411 conserved gate region; other site 754507005412 ABC-ATPase subunit interface; other site 754507005413 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 754507005414 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 754507005415 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 754507005416 Walker A/P-loop; other site 754507005417 ATP binding site [chemical binding]; other site 754507005418 Q-loop/lid; other site 754507005419 ABC transporter signature motif; other site 754507005420 Walker B; other site 754507005421 D-loop; other site 754507005422 H-loop/switch region; other site 754507005423 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 754507005424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 754507005425 catalytic residue [active] 754507005426 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 754507005427 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 754507005428 active site 754507005429 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 754507005430 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 754507005431 nucleotide binding site [chemical binding]; other site 754507005432 substrate binding site [chemical binding]; other site 754507005433 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 754507005434 dimer interface [polypeptide binding]; other site 754507005435 putative threonine allosteric regulatory site; other site 754507005436 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 754507005437 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 754507005438 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 754507005439 homoserine kinase; Provisional; Region: PRK01212 754507005440 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 754507005441 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 754507005442 threonine synthase; Validated; Region: PRK09225 754507005443 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 754507005444 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754507005445 catalytic residue [active] 754507005446 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 754507005447 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 754507005448 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 754507005449 HflK protein; Region: hflK; TIGR01933 754507005450 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 754507005451 FtsH protease regulator HflC; Provisional; Region: PRK11029 754507005452 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 754507005453 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 754507005454 active site 754507005455 dimerization interface [polypeptide binding]; other site 754507005456 Uncharacterized conserved protein [Function unknown]; Region: COG0393 754507005457 HemN family oxidoreductase; Provisional; Region: PRK05660 754507005458 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 754507005459 FeS/SAM binding site; other site 754507005460 HemN C-terminal domain; Region: HemN_C; pfam06969 754507005461 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 754507005462 tetramer (dimer of dimers) interface [polypeptide binding]; other site 754507005463 active site 754507005464 dimer interface [polypeptide binding]; other site 754507005465 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 754507005466 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 754507005467 ligand binding site [chemical binding]; other site 754507005468 NAD binding site [chemical binding]; other site 754507005469 tetramer interface [polypeptide binding]; other site 754507005470 catalytic site [active] 754507005471 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 754507005472 L-serine binding site [chemical binding]; other site 754507005473 ACT domain interface; other site 754507005474 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 754507005475 putative ligand binding residues [chemical binding]; other site 754507005476 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 754507005477 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 754507005478 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 754507005479 active site 754507005480 intersubunit interface [polypeptide binding]; other site 754507005481 catalytic residue [active] 754507005482 Glucuronate isomerase; Region: UxaC; pfam02614 754507005483 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 754507005484 D-mannonate oxidoreductase; Provisional; Region: PRK08277 754507005485 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 754507005486 putative NAD(P) binding site [chemical binding]; other site 754507005487 active site 754507005488 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754507005489 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 754507005490 substrate binding site [chemical binding]; other site 754507005491 ATP binding site [chemical binding]; other site 754507005492 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 754507005493 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 754507005494 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 754507005495 DctM-like transporters; Region: DctM; pfam06808 754507005496 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 754507005497 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 754507005498 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 754507005499 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 754507005500 putative active site [active] 754507005501 putative catalytic site [active] 754507005502 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 754507005503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 754507005504 DNA-binding site [nucleotide binding]; DNA binding site 754507005505 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 754507005506 mannonate dehydratase; Provisional; Region: PRK03906 754507005507 mannonate dehydratase; Region: uxuA; TIGR00695 754507005508 putative transporter; Provisional; Region: PRK11660 754507005509 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 754507005510 Sulfate transporter family; Region: Sulfate_transp; pfam00916 754507005511 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 754507005512 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 754507005513 Found in ATP-dependent protease La (LON); Region: LON; smart00464 754507005514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507005515 Walker A motif; other site 754507005516 ATP binding site [chemical binding]; other site 754507005517 Walker B motif; other site 754507005518 arginine finger; other site 754507005519 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 754507005520 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 754507005521 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 754507005522 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 754507005523 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 754507005524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 754507005525 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 754507005526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 754507005527 DNA binding residues [nucleotide binding] 754507005528 DNA primase; Validated; Region: dnaG; PRK05667 754507005529 CHC2 zinc finger; Region: zf-CHC2; pfam01807 754507005530 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 754507005531 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 754507005532 active site 754507005533 metal binding site [ion binding]; metal-binding site 754507005534 interdomain interaction site; other site 754507005535 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 754507005536 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 754507005537 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 754507005538 UGMP family protein; Validated; Region: PRK09604 754507005539 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 754507005540 thymidine kinase; Provisional; Region: PRK04296 754507005541 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 754507005542 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 754507005543 nucleotide binding pocket [chemical binding]; other site 754507005544 K-X-D-G motif; other site 754507005545 catalytic site [active] 754507005546 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 754507005547 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 754507005548 Helix-hairpin-helix motif; Region: HHH; pfam00633 754507005549 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 754507005550 Dimer interface [polypeptide binding]; other site 754507005551 BRCT sequence motif; other site 754507005552 cell division protein ZipA; Provisional; Region: PRK01741 754507005553 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 754507005554 FtsZ protein binding site [polypeptide binding]; other site 754507005555 putative sulfate transport protein CysZ; Validated; Region: PRK04949 754507005556 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 754507005557 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 754507005558 dimer interface [polypeptide binding]; other site 754507005559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507005560 catalytic residue [active] 754507005561 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 754507005562 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 754507005563 putative uracil binding site [chemical binding]; other site 754507005564 putative active site [active] 754507005565 GTP-binding protein YchF; Reviewed; Region: PRK09601 754507005566 YchF GTPase; Region: YchF; cd01900 754507005567 G1 box; other site 754507005568 GTP/Mg2+ binding site [chemical binding]; other site 754507005569 Switch I region; other site 754507005570 G2 box; other site 754507005571 Switch II region; other site 754507005572 G3 box; other site 754507005573 G4 box; other site 754507005574 G5 box; other site 754507005575 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 754507005576 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 754507005577 putative active site [active] 754507005578 catalytic residue [active] 754507005579 putative transposase OrfB; Reviewed; Region: PHA02517 754507005580 Integrase core domain; Region: rve; pfam00665 754507005581 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 754507005582 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 754507005583 Mg++ binding site [ion binding]; other site 754507005584 putative catalytic motif [active] 754507005585 substrate binding site [chemical binding]; other site 754507005586 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 754507005587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 754507005588 inhibitor-cofactor binding pocket; inhibition site 754507005589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507005590 catalytic residue [active] 754507005591 PII uridylyl-transferase; Provisional; Region: glnD; PRK01759 754507005592 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 754507005593 metal binding triad; other site 754507005594 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 754507005595 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754507005596 Zn2+ binding site [ion binding]; other site 754507005597 Mg2+ binding site [ion binding]; other site 754507005598 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 754507005599 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 754507005600 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 754507005601 active site 754507005602 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 754507005603 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 754507005604 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 754507005605 Transglycosylase; Region: Transgly; pfam00912 754507005606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 754507005607 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 754507005608 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 754507005609 Predicted membrane protein [Function unknown]; Region: COG4393 754507005610 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 754507005611 Uncharacterized conserved protein [Function unknown]; Region: COG3350 754507005612 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754507005613 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 754507005614 FtsX-like permease family; Region: FtsX; pfam02687 754507005615 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 754507005616 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 754507005617 FtsX-like permease family; Region: FtsX; pfam02687 754507005618 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 754507005619 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 754507005620 Walker A/P-loop; other site 754507005621 ATP binding site [chemical binding]; other site 754507005622 Q-loop/lid; other site 754507005623 ABC transporter signature motif; other site 754507005624 Walker B; other site 754507005625 D-loop; other site 754507005626 H-loop/switch region; other site 754507005627 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 754507005628 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 754507005629 catalytic residues [active] 754507005630 Cytochrome c; Region: Cytochrom_C; cl11414 754507005631 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 754507005632 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 754507005633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 754507005634 motif II; other site 754507005635 Domain of unknown function (DUF4372); Region: DUF4372; pfam14294 754507005636 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 754507005637 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 754507005638 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 754507005639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507005640 ATP binding site [chemical binding]; other site 754507005641 putative Mg++ binding site [ion binding]; other site 754507005642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507005643 nucleotide binding region [chemical binding]; other site 754507005644 ATP-binding site [chemical binding]; other site 754507005645 Helicase associated domain (HA2); Region: HA2; pfam04408 754507005646 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 754507005647 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 754507005648 Protein of unknown function (DUF423); Region: DUF423; cl01008 754507005649 Predicted membrane protein [Function unknown]; Region: COG2707 754507005650 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 754507005651 putative GSH binding site [chemical binding]; other site 754507005652 catalytic residues [active] 754507005653 outer membrane protein A; Reviewed; Region: PRK10808 754507005654 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 754507005655 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754507005656 ligand binding site [chemical binding]; other site 754507005657 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 754507005658 FAD binding domain; Region: FAD_binding_4; pfam01565 754507005659 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 754507005660 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 754507005661 CoenzymeA binding site [chemical binding]; other site 754507005662 subunit interaction site [polypeptide binding]; other site 754507005663 PHB binding site; other site 754507005664 ferrochelatase; Reviewed; Region: hemH; PRK00035 754507005665 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 754507005666 C-terminal domain interface [polypeptide binding]; other site 754507005667 active site 754507005668 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 754507005669 active site 754507005670 N-terminal domain interface [polypeptide binding]; other site 754507005671 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 754507005672 dimer interface [polypeptide binding]; other site 754507005673 catalytic triad [active] 754507005674 peroxidatic and resolving cysteines [active] 754507005675 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 754507005676 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 754507005677 active site 754507005678 dimer interface [polypeptide binding]; other site 754507005679 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 754507005680 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 754507005681 active site 754507005682 trimer interface [polypeptide binding]; other site 754507005683 allosteric site; other site 754507005684 active site lid [active] 754507005685 hexamer (dimer of trimers) interface [polypeptide binding]; other site 754507005686 N-acetylneuraminate lyase; Provisional; Region: PRK04147 754507005687 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 754507005688 inhibitor site; inhibition site 754507005689 active site 754507005690 dimer interface [polypeptide binding]; other site 754507005691 catalytic residue [active] 754507005692 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754507005693 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754507005694 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754507005695 putative active site [active] 754507005696 N-acetylmannosamine kinase; Provisional; Region: PRK05082 754507005697 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754507005698 nucleotide binding site [chemical binding]; other site 754507005699 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 754507005700 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 754507005701 putative active site cavity [active] 754507005702 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 754507005703 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 754507005704 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 754507005705 DctM-like transporters; Region: DctM; pfam06808 754507005706 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 754507005707 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 754507005708 Kelch motif; Region: Kelch_1; pfam01344 754507005709 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 754507005710 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 754507005711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 754507005712 active site turn [active] 754507005713 phosphorylation site [posttranslational modification] 754507005714 outer membrane protein A; Reviewed; Region: PRK10808 754507005715 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 754507005716 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 754507005717 ligand binding site [chemical binding]; other site 754507005718 excinuclease ABC subunit B; Provisional; Region: PRK05298 754507005719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507005720 ATP binding site [chemical binding]; other site 754507005721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507005722 nucleotide binding region [chemical binding]; other site 754507005723 ATP-binding site [chemical binding]; other site 754507005724 Ultra-violet resistance protein B; Region: UvrB; pfam12344 754507005725 UvrB/uvrC motif; Region: UVR; pfam02151 754507005726 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 754507005727 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 754507005728 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 754507005729 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507005730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507005731 ABC transporter; Region: ABC_tran_2; pfam12848 754507005732 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507005733 YadA-like C-terminal region; Region: YadA; pfam03895 754507005734 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 754507005735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 754507005736 ATP binding site [chemical binding]; other site 754507005737 Mg2+ binding site [ion binding]; other site 754507005738 G-X-G motif; other site 754507005739 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 754507005740 anchoring element; other site 754507005741 dimer interface [polypeptide binding]; other site 754507005742 ATP binding site [chemical binding]; other site 754507005743 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 754507005744 active site 754507005745 putative metal-binding site [ion binding]; other site 754507005746 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 754507005747 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 754507005748 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754507005749 CAP-like domain; other site 754507005750 active site 754507005751 primary dimer interface [polypeptide binding]; other site 754507005752 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 754507005753 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 754507005754 C-terminal domain interface [polypeptide binding]; other site 754507005755 GSH binding site (G-site) [chemical binding]; other site 754507005756 dimer interface [polypeptide binding]; other site 754507005757 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 754507005758 dimer interface [polypeptide binding]; other site 754507005759 substrate binding pocket (H-site) [chemical binding]; other site 754507005760 N-terminal domain interface [polypeptide binding]; other site 754507005761 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 754507005762 Sel1-like repeats; Region: SEL1; smart00671 754507005763 Sel1 repeat; Region: Sel1; cl02723 754507005764 Sel1-like repeats; Region: SEL1; smart00671 754507005765 Sel1 repeat; Region: Sel1; cl02723 754507005766 YwiC-like protein; Region: YwiC; pfam14256 754507005767 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 754507005768 homotrimer interaction site [polypeptide binding]; other site 754507005769 putative active site [active] 754507005770 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 754507005771 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 754507005772 Ligand binding site; other site 754507005773 Putative Catalytic site; other site 754507005774 DXD motif; other site 754507005775 hypothetical protein; Provisional; Region: PRK05421 754507005776 putative catalytic site [active] 754507005777 putative metal binding site [ion binding]; other site 754507005778 putative phosphate binding site [ion binding]; other site 754507005779 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 754507005780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507005781 Walker A motif; other site 754507005782 ATP binding site [chemical binding]; other site 754507005783 Walker B motif; other site 754507005784 DNA polymerase III subunit delta'; Validated; Region: PRK08485 754507005785 arginine finger; other site 754507005786 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 754507005787 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 754507005788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507005789 active site 754507005790 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 754507005791 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754507005792 putative acyl-acceptor binding pocket; other site 754507005793 hypothetical protein; Provisional; Region: PRK10621 754507005794 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 754507005795 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 754507005796 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 754507005797 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 754507005798 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 754507005799 Tetramer interface [polypeptide binding]; other site 754507005800 active site 754507005801 FMN-binding site [chemical binding]; other site 754507005802 hypothetical protein; Provisional; Region: PRK11281 754507005803 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 754507005804 Mechanosensitive ion channel; Region: MS_channel; pfam00924 754507005805 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 754507005806 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 754507005807 acyl-activating enzyme (AAE) consensus motif; other site 754507005808 putative AMP binding site [chemical binding]; other site 754507005809 putative active site [active] 754507005810 putative CoA binding site [chemical binding]; other site 754507005811 replication initiation regulator SeqA; Provisional; Region: PRK11187 754507005812 acyl-CoA esterase; Provisional; Region: PRK10673 754507005813 PGAP1-like protein; Region: PGAP1; pfam07819 754507005814 flavodoxin FldA; Validated; Region: PRK09267 754507005815 ferric uptake regulator; Provisional; Region: fur; PRK09462 754507005816 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 754507005817 metal binding site 2 [ion binding]; metal-binding site 754507005818 putative DNA binding helix; other site 754507005819 metal binding site 1 [ion binding]; metal-binding site 754507005820 dimer interface [polypeptide binding]; other site 754507005821 structural Zn2+ binding site [ion binding]; other site 754507005822 DNA gyrase subunit A; Validated; Region: PRK05560 754507005823 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 754507005824 CAP-like domain; other site 754507005825 active site 754507005826 primary dimer interface [polypeptide binding]; other site 754507005827 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754507005828 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754507005829 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754507005830 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754507005831 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754507005832 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 754507005833 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 754507005834 translation initiation factor Sui1; Validated; Region: PRK06824 754507005835 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 754507005836 putative rRNA binding site [nucleotide binding]; other site 754507005837 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 754507005838 active site 754507005839 dimer interface [polypeptide binding]; other site 754507005840 tetratricopeptide repeat protein; Provisional; Region: PRK11788 754507005841 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754507005842 Predicted membrane protein [Function unknown]; Region: COG3771 754507005843 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 754507005844 IHF dimer interface [polypeptide binding]; other site 754507005845 IHF - DNA interface [nucleotide binding]; other site 754507005846 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 754507005847 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 754507005848 RNA binding site [nucleotide binding]; other site 754507005849 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 754507005850 RNA binding site [nucleotide binding]; other site 754507005851 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 754507005852 RNA binding site [nucleotide binding]; other site 754507005853 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 754507005854 RNA binding site [nucleotide binding]; other site 754507005855 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 754507005856 RNA binding site [nucleotide binding]; other site 754507005857 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 754507005858 RNA binding site [nucleotide binding]; other site 754507005859 cytidylate kinase; Provisional; Region: cmk; PRK00023 754507005860 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 754507005861 CMP-binding site; other site 754507005862 The sites determining sugar specificity; other site 754507005863 Protein of unknown function (DUF535); Region: DUF535; pfam04393 754507005864 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 754507005865 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754507005866 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 754507005867 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 754507005868 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754507005869 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 754507005870 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 754507005871 AzlC protein; Region: AzlC; cl00570 754507005872 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 754507005873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 754507005874 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 754507005875 putative dimerization interface [polypeptide binding]; other site 754507005876 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 754507005877 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 754507005878 THF binding site; other site 754507005879 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 754507005880 substrate binding site [chemical binding]; other site 754507005881 THF binding site; other site 754507005882 zinc-binding site [ion binding]; other site 754507005883 DEAD-like helicases superfamily; Region: DEXDc; smart00487 754507005884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 754507005885 ATP binding site [chemical binding]; other site 754507005886 putative Mg++ binding site [ion binding]; other site 754507005887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 754507005888 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 754507005889 nucleotide binding region [chemical binding]; other site 754507005890 ATP-binding site [chemical binding]; other site 754507005891 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 754507005892 YccA-like proteins; Region: YccA_like; cd10433 754507005893 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 754507005894 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 754507005895 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 754507005896 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 754507005897 metal binding site [ion binding]; metal-binding site 754507005898 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 754507005899 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 754507005900 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754507005901 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507005902 ABC-ATPase subunit interface; other site 754507005903 dimer interface [polypeptide binding]; other site 754507005904 putative PBP binding regions; other site 754507005905 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 754507005906 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 754507005907 ABC-ATPase subunit interface; other site 754507005908 dimer interface [polypeptide binding]; other site 754507005909 putative PBP binding regions; other site 754507005910 acylphosphatase; Provisional; Region: PRK14448 754507005911 hypothetical protein; Provisional; Region: PRK03641 754507005912 hypothetical protein; Provisional; Region: PRK01904 754507005913 Predicted membrane protein [Function unknown]; Region: COG3304 754507005914 Domain of unknown function (DUF307); Region: DUF307; pfam03733 754507005915 Domain of unknown function (DUF307); Region: DUF307; pfam03733 754507005916 TIGR01666 family membrane protein; Region: YCCS 754507005917 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 754507005918 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 754507005919 hypothetical protein; Provisional; Region: PRK04946 754507005920 Smr domain; Region: Smr; pfam01713 754507005921 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 754507005922 HemK family putative methylases; Region: hemK_fam; TIGR00536 754507005923 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 754507005924 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 754507005925 PYR/PP interface [polypeptide binding]; other site 754507005926 dimer interface [polypeptide binding]; other site 754507005927 TPP binding site [chemical binding]; other site 754507005928 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 754507005929 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 754507005930 TPP-binding site [chemical binding]; other site 754507005931 dimer interface [polypeptide binding]; other site 754507005932 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754507005933 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 754507005934 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 754507005935 active site 754507005936 P-loop; other site 754507005937 phosphorylation site [posttranslational modification] 754507005938 ABC transporter ATPase component; Reviewed; Region: PRK11147 754507005939 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507005940 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507005941 ABC transporter; Region: ABC_tran_2; pfam12848 754507005942 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 754507005943 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 754507005944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 754507005945 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 754507005946 LrgB-like family; Region: LrgB; cl00596 754507005947 hypothetical protein; Provisional; Region: PRK01821 754507005948 Staphylococcal nuclease homologues; Region: SNc; smart00318 754507005949 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 754507005950 Catalytic site; other site 754507005951 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 754507005952 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 754507005953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754507005954 catalytic residue [active] 754507005955 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 754507005956 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 754507005957 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 754507005958 putative ribose interaction site [chemical binding]; other site 754507005959 putative ADP binding site [chemical binding]; other site 754507005960 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 754507005961 active site 754507005962 nucleotide binding site [chemical binding]; other site 754507005963 HIGH motif; other site 754507005964 KMSKS motif; other site 754507005965 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 754507005966 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 754507005967 putative acyl-acceptor binding pocket; other site 754507005968 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 754507005969 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 754507005970 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 754507005971 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 754507005972 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 754507005973 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 754507005974 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 754507005975 Domain of unknown function DUF302; Region: DUF302; pfam03625 754507005976 Protein of unknown function, DUF417; Region: DUF417; cl01162 754507005977 Haem-binding domain; Region: Haem_bd; pfam14376 754507005978 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 754507005979 ribonuclease D; Provisional; Region: PRK10829 754507005980 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 754507005981 catalytic site [active] 754507005982 putative active site [active] 754507005983 putative substrate binding site [chemical binding]; other site 754507005984 HRDC domain; Region: HRDC; pfam00570 754507005985 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 754507005986 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 754507005987 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 754507005988 acyl-activating enzyme (AAE) consensus motif; other site 754507005989 putative AMP binding site [chemical binding]; other site 754507005990 putative active site [active] 754507005991 putative CoA binding site [chemical binding]; other site 754507005992 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 754507005993 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 754507005994 Glycoprotease family; Region: Peptidase_M22; pfam00814 754507005995 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 754507005996 DEAD_2; Region: DEAD_2; pfam06733 754507005997 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 754507005998 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 754507005999 active site 754507006000 phosphate binding residues; other site 754507006001 catalytic residues [active] 754507006002 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 754507006003 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 754507006004 thioredoxin reductase; Provisional; Region: PRK10262 754507006005 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 754507006006 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 754507006007 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 754507006008 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754507006009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 754507006010 Walker A/P-loop; other site 754507006011 ATP binding site [chemical binding]; other site 754507006012 Q-loop/lid; other site 754507006013 ABC transporter signature motif; other site 754507006014 Walker B; other site 754507006015 D-loop; other site 754507006016 H-loop/switch region; other site 754507006017 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 754507006018 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754507006019 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 754507006020 Walker A/P-loop; other site 754507006021 ATP binding site [chemical binding]; other site 754507006022 Q-loop/lid; other site 754507006023 ABC transporter signature motif; other site 754507006024 Walker B; other site 754507006025 D-loop; other site 754507006026 H-loop/switch region; other site 754507006027 acyl-CoA thioesterase II; Provisional; Region: PRK10526 754507006028 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 754507006029 active site 754507006030 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 754507006031 catalytic triad [active] 754507006032 dimer interface [polypeptide binding]; other site 754507006033 Phosphotransferase enzyme family; Region: APH; pfam01636 754507006034 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 754507006035 active site 754507006036 ATP binding site [chemical binding]; other site 754507006037 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 754507006038 fructokinase; Reviewed; Region: PRK09557 754507006039 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 754507006040 nucleotide binding site [chemical binding]; other site 754507006041 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 754507006042 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 754507006043 active site 754507006044 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 754507006045 dimerization interface [polypeptide binding]; other site 754507006046 active site 754507006047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754507006048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754507006049 NAD(P) binding site [chemical binding]; other site 754507006050 Family of unknown function (DUF695); Region: DUF695; pfam05117 754507006051 TIGR01619 family protein; Region: hyp_HI0040 754507006052 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 754507006053 putative catalytic site [active] 754507006054 putative phosphate binding site [ion binding]; other site 754507006055 active site 754507006056 metal binding site A [ion binding]; metal-binding site 754507006057 DNA binding site [nucleotide binding] 754507006058 putative AP binding site [nucleotide binding]; other site 754507006059 putative metal binding site B [ion binding]; other site 754507006060 Bacterial sugar transferase; Region: Bac_transf; cl00939 754507006061 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 754507006062 Bacterial sugar transferase; Region: Bac_transf; pfam02397 754507006063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754507006064 active site 754507006065 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754507006066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754507006067 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 754507006068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754507006069 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 754507006070 Ligand binding site; other site 754507006071 Putative Catalytic site; other site 754507006072 DXD motif; other site 754507006073 Predicted membrane protein [Function unknown]; Region: COG2246 754507006074 GtrA-like protein; Region: GtrA; pfam04138 754507006075 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 754507006076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 754507006077 active site 754507006078 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 754507006079 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 754507006080 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754507006081 active site 754507006082 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 754507006083 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 754507006084 Walker A/P-loop; other site 754507006085 ATP binding site [chemical binding]; other site 754507006086 Q-loop/lid; other site 754507006087 ABC transporter signature motif; other site 754507006088 Walker B; other site 754507006089 D-loop; other site 754507006090 H-loop/switch region; other site 754507006091 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 754507006092 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 754507006093 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 754507006094 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 754507006095 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 754507006096 NADP binding site [chemical binding]; other site 754507006097 active site 754507006098 putative substrate binding site [chemical binding]; other site 754507006099 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 754507006100 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 754507006101 substrate binding site; other site 754507006102 tetramer interface; other site 754507006103 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 754507006104 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 754507006105 NAD binding site [chemical binding]; other site 754507006106 substrate binding site [chemical binding]; other site 754507006107 homodimer interface [polypeptide binding]; other site 754507006108 active site 754507006109 lytic murein transglycosylase; Region: MltB_2; TIGR02283 754507006110 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 754507006111 N-acetyl-D-glucosamine binding site [chemical binding]; other site 754507006112 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754507006113 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 754507006114 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 754507006115 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 754507006116 active site 754507006117 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 754507006118 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 754507006119 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 754507006120 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 754507006121 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 754507006122 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 754507006123 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 754507006124 Uncharacterized conserved protein [Function unknown]; Region: COG1434 754507006125 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 754507006126 putative active site [active] 754507006127 DNA ligase; Provisional; Region: PRK09125 754507006128 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 754507006129 DNA binding site [nucleotide binding] 754507006130 active site 754507006131 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 754507006132 DNA binding site [nucleotide binding] 754507006133 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 754507006134 Part of AAA domain; Region: AAA_19; pfam13245 754507006135 Family description; Region: UvrD_C_2; pfam13538 754507006136 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 754507006137 fructuronate transporter; Provisional; Region: PRK10034; cl15264 754507006138 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 754507006139 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 754507006140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 754507006141 DNA binding site [nucleotide binding] 754507006142 domain linker motif; other site 754507006143 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 754507006144 putative ligand binding site [chemical binding]; other site 754507006145 putative dimerization interface [polypeptide binding]; other site 754507006146 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 754507006147 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754507006148 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754507006149 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754507006150 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 754507006151 molybdopterin cofactor binding site; other site 754507006152 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 754507006153 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754507006154 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 754507006155 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 754507006156 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 754507006157 Acylphosphatase; Region: Acylphosphatase; pfam00708 754507006158 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 754507006159 HypF finger; Region: zf-HYPF; pfam07503 754507006160 HypF finger; Region: zf-HYPF; pfam07503 754507006161 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 754507006162 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 754507006163 4Fe-4S binding domain; Region: Fer4; pfam00037 754507006164 hydrogenase 4 subunit B; Validated; Region: PRK06521 754507006165 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754507006166 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 754507006167 NADH dehydrogenase; Region: NADHdh; cl00469 754507006168 hydrogenase 4 subunit D; Validated; Region: PRK06525 754507006169 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754507006170 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 754507006171 hydrogenase 4 subunit F; Validated; Region: PRK06458 754507006172 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 754507006173 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 754507006174 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 754507006175 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 754507006176 hydrogenase 4 subunit H; Validated; Region: PRK08222 754507006177 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 754507006178 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 754507006179 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 754507006180 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 754507006181 nickel binding site [ion binding]; other site 754507006182 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754507006183 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 754507006184 molybdopterin cofactor binding site; other site 754507006185 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 754507006186 molybdopterin cofactor binding site; other site 754507006187 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 754507006188 CoA binding domain; Region: CoA_binding; smart00881 754507006189 CoA-ligase; Region: Ligase_CoA; pfam00549 754507006190 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 754507006191 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 754507006192 CoA-ligase; Region: Ligase_CoA; pfam00549 754507006193 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 754507006194 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 754507006195 E3 interaction surface; other site 754507006196 lipoyl attachment site [posttranslational modification]; other site 754507006197 e3 binding domain; Region: E3_binding; pfam02817 754507006198 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 754507006199 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 754507006200 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 754507006201 TPP-binding site [chemical binding]; other site 754507006202 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 754507006203 PYR/PP interface [polypeptide binding]; other site 754507006204 dimer interface [polypeptide binding]; other site 754507006205 TPP binding site [chemical binding]; other site 754507006206 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 754507006207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 754507006208 Peptidase M15; Region: Peptidase_M15_3; cl01194 754507006209 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754507006210 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 754507006211 carboxy-terminal protease; Provisional; Region: PRK11186 754507006212 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 754507006213 protein binding site [polypeptide binding]; other site 754507006214 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 754507006215 Catalytic dyad [active] 754507006216 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 754507006217 ProP expression regulator; Provisional; Region: PRK04950 754507006218 ProQ/FINO family; Region: ProQ; pfam04352 754507006219 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 754507006220 Paraquat-inducible protein A; Region: PqiA; pfam04403 754507006221 Paraquat-inducible protein A; Region: PqiA; pfam04403 754507006222 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 754507006223 mce related protein; Region: MCE; pfam02470 754507006224 mce related protein; Region: MCE; pfam02470 754507006225 mce related protein; Region: MCE; pfam02470 754507006226 mce related protein; Region: MCE; pfam02470 754507006227 mce related protein; Region: MCE; pfam02470 754507006228 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 754507006229 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 754507006230 metal binding site [ion binding]; metal-binding site 754507006231 dimer interface [polypeptide binding]; other site 754507006232 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 754507006233 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 754507006234 Walker A/P-loop; other site 754507006235 ATP binding site [chemical binding]; other site 754507006236 Q-loop/lid; other site 754507006237 ABC transporter signature motif; other site 754507006238 Walker B; other site 754507006239 D-loop; other site 754507006240 H-loop/switch region; other site 754507006241 TOBE domain; Region: TOBE_2; pfam08402 754507006242 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754507006243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507006244 dimer interface [polypeptide binding]; other site 754507006245 conserved gate region; other site 754507006246 putative PBP binding loops; other site 754507006247 ABC-ATPase subunit interface; other site 754507006248 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 754507006249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 754507006250 dimer interface [polypeptide binding]; other site 754507006251 conserved gate region; other site 754507006252 ABC-ATPase subunit interface; other site 754507006253 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 754507006254 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 754507006255 cytidine deaminase; Provisional; Region: PRK09027 754507006256 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 754507006257 active site 754507006258 catalytic motif [active] 754507006259 Zn binding site [ion binding]; other site 754507006260 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 754507006261 active site 754507006262 catalytic motif [active] 754507006263 Zn binding site [ion binding]; other site 754507006264 seryl-tRNA synthetase; Provisional; Region: PRK05431 754507006265 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 754507006266 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 754507006267 dimer interface [polypeptide binding]; other site 754507006268 active site 754507006269 motif 1; other site 754507006270 motif 2; other site 754507006271 motif 3; other site 754507006272 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 754507006273 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 754507006274 recombination factor protein RarA; Reviewed; Region: PRK13342 754507006275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 754507006276 Walker A motif; other site 754507006277 ATP binding site [chemical binding]; other site 754507006278 Walker B motif; other site 754507006279 arginine finger; other site 754507006280 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 754507006281 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 754507006282 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 754507006283 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 754507006284 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 754507006285 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 754507006286 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 754507006287 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 754507006288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 754507006289 dimerization interface [polypeptide binding]; other site 754507006290 putative DNA binding site [nucleotide binding]; other site 754507006291 putative Zn2+ binding site [ion binding]; other site 754507006292 AsnC family; Region: AsnC_trans_reg; pfam01037 754507006293 DNA repair protein RadA; Provisional; Region: PRK11823 754507006294 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754507006295 Walker A motif; other site 754507006296 ATP binding site [chemical binding]; other site 754507006297 Walker B motif; other site 754507006298 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 754507006299 Uncharacterized conserved protein [Function unknown]; Region: COG3025 754507006300 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 754507006301 putative active site [active] 754507006302 putative metal binding residues [ion binding]; other site 754507006303 signature motif; other site 754507006304 putative triphosphate binding site [ion binding]; other site 754507006305 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 754507006306 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754507006307 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 754507006308 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 754507006309 Bacterial SH3 domain homologues; Region: SH3b; smart00287 754507006310 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 754507006311 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 754507006312 active site 754507006313 NTP binding site [chemical binding]; other site 754507006314 metal binding triad [ion binding]; metal-binding site 754507006315 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 754507006316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 754507006317 Zn2+ binding site [ion binding]; other site 754507006318 Mg2+ binding site [ion binding]; other site 754507006319 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 754507006320 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 754507006321 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 754507006322 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 754507006323 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 754507006324 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 754507006325 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 754507006326 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 754507006327 active site 754507006328 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 754507006329 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 754507006330 phosphate binding site [ion binding]; other site 754507006331 L-lactate permease; Region: Lactate_perm; cl00701 754507006332 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 754507006333 hypothetical protein; Provisional; Region: PRK05423 754507006334 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 754507006335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 754507006336 catalytic residue [active] 754507006337 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 754507006338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754507006339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507006340 homodimer interface [polypeptide binding]; other site 754507006341 catalytic residue [active] 754507006342 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 754507006343 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 754507006344 hinge; other site 754507006345 active site 754507006346 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 754507006347 RNA/DNA hybrid binding site [nucleotide binding]; other site 754507006348 active site 754507006349 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 754507006350 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 754507006351 active site 754507006352 catalytic site [active] 754507006353 substrate binding site [chemical binding]; other site 754507006354 primosomal protein DnaI; Provisional; Region: PRK02854 754507006355 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 754507006356 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 754507006357 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 754507006358 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 754507006359 putative protease; Provisional; Region: PRK15452 754507006360 Peptidase family U32; Region: Peptidase_U32; pfam01136 754507006361 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 754507006362 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 754507006363 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 754507006364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 754507006365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 754507006366 homodimer interface [polypeptide binding]; other site 754507006367 catalytic residue [active] 754507006368 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 754507006369 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 754507006370 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 754507006371 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 754507006372 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 754507006373 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 754507006374 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 754507006375 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 754507006376 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 754507006377 Protein export membrane protein; Region: SecD_SecF; pfam02355 754507006378 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 754507006379 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 754507006380 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 754507006381 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 754507006382 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 754507006383 putative catalytic cysteine [active] 754507006384 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 754507006385 putative active site [active] 754507006386 metal binding site [ion binding]; metal-binding site 754507006387 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 754507006388 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 754507006389 TM-ABC transporter signature motif; other site 754507006390 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 754507006391 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 754507006392 Walker A/P-loop; other site 754507006393 ATP binding site [chemical binding]; other site 754507006394 Q-loop/lid; other site 754507006395 ABC transporter signature motif; other site 754507006396 Walker B; other site 754507006397 D-loop; other site 754507006398 H-loop/switch region; other site 754507006399 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 754507006400 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754507006401 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 754507006402 putative ligand binding site [chemical binding]; other site 754507006403 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 754507006404 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 754507006405 putative ligand binding site [chemical binding]; other site 754507006406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754507006407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754507006408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754507006409 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 754507006410 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 754507006411 tetrameric interface [polypeptide binding]; other site 754507006412 NAD binding site [chemical binding]; other site 754507006413 catalytic residues [active] 754507006414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 754507006415 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 754507006416 putative substrate translocation pore; other site 754507006417 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 754507006418 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 754507006419 active site 754507006420 dimerization interface [polypeptide binding]; other site 754507006421 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 754507006422 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 754507006423 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 754507006424 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 754507006425 putative active site [active] 754507006426 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 754507006427 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 754507006428 substrate binding site [chemical binding]; other site 754507006429 ATP binding site [chemical binding]; other site 754507006430 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 754507006431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 754507006432 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 754507006433 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 754507006434 PYR/PP interface [polypeptide binding]; other site 754507006435 dimer interface [polypeptide binding]; other site 754507006436 TPP binding site [chemical binding]; other site 754507006437 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 754507006438 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 754507006439 TPP-binding site; other site 754507006440 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 754507006441 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 754507006442 Metal-binding active site; metal-binding site 754507006443 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 754507006444 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 754507006445 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 754507006446 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 754507006447 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 754507006448 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 754507006449 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 754507006450 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 754507006451 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 754507006452 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 754507006453 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 754507006454 active site 754507006455 P-loop; other site 754507006456 phosphorylation site [posttranslational modification] 754507006457 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 754507006458 active site 754507006459 phosphorylation site [posttranslational modification] 754507006460 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 754507006461 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 754507006462 HlyD family secretion protein; Region: HlyD_3; pfam13437 754507006463 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 754507006464 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 754507006465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 754507006466 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 754507006467 Walker A/P-loop; other site 754507006468 ATP binding site [chemical binding]; other site 754507006469 Q-loop/lid; other site 754507006470 ABC transporter signature motif; other site 754507006471 Walker B; other site 754507006472 D-loop; other site 754507006473 H-loop/switch region; other site 754507006474 RTX N-terminal domain; Region: RTX; pfam02382 754507006475 RTX C-terminal domain; Region: RTX_C; pfam08339 754507006476 RTX toxin acyltransferase family; Region: HlyC; pfam02794 754507006477 Actinobacillus actinomycetemcomitans leukotoxin activator LktC; Region: LktC; pfam06261 754507006478 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 754507006479 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 754507006480 dimer interface [polypeptide binding]; other site 754507006481 active site 754507006482 glycine-pyridoxal phosphate binding site [chemical binding]; other site 754507006483 folate binding site [chemical binding]; other site 754507006484 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 754507006485 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 754507006486 active site turn [active] 754507006487 phosphorylation site [posttranslational modification] 754507006488 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 754507006489 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 754507006490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 754507006491 S-adenosylmethionine binding site [chemical binding]; other site 754507006492 DNA polymerase III subunit psi; Validated; Region: PRK06856 754507006493 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 754507006494 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 754507006495 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 754507006496 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 754507006497 Protein of unknown function (DUF2572); Region: DUF2572; pfam10833 754507006498 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 754507006499 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 754507006500 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 754507006501 Type IV secretion system proteins; Region: T4SS; pfam07996 754507006502 CotJB protein; Region: CotJB; pfam12652 754507006503 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 754507006504 VirB8 protein; Region: VirB8; pfam04335 754507006505 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 754507006506 VirB7 interaction site; other site 754507006507 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 754507006508 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 754507006509 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 754507006510 Walker A motif; other site 754507006511 hexamer interface [polypeptide binding]; other site 754507006512 ATP binding site [chemical binding]; other site 754507006513 Walker B motif; other site 754507006514 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 754507006515 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 754507006516 Walker A motif; other site 754507006517 ATP binding site [chemical binding]; other site 754507006518 Walker B motif; other site 754507006519 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117