-- dump date 20140618_192525 -- class Genbank::misc_feature -- table misc_feature_note -- id note 694569000001 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 694569000002 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 694569000003 phosphate binding site [ion binding]; other site 694569000004 putative substrate binding pocket [chemical binding]; other site 694569000005 dimer interface [polypeptide binding]; other site 694569000006 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 694569000007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569000008 FeS/SAM binding site; other site 694569000009 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 694569000010 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 694569000011 trimer interface [polypeptide binding]; other site 694569000012 dimer interface [polypeptide binding]; other site 694569000013 putative active site [active] 694569000014 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 694569000015 MoaE interaction surface [polypeptide binding]; other site 694569000016 MoeB interaction surface [polypeptide binding]; other site 694569000017 thiocarboxylated glycine; other site 694569000018 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 694569000019 MoaE homodimer interface [polypeptide binding]; other site 694569000020 MoaD interaction [polypeptide binding]; other site 694569000021 active site residues [active] 694569000022 stringent starvation protein A; Provisional; Region: sspA; PRK09481 694569000023 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 694569000024 C-terminal domain interface [polypeptide binding]; other site 694569000025 putative GSH binding site (G-site) [chemical binding]; other site 694569000026 dimer interface [polypeptide binding]; other site 694569000027 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 694569000028 dimer interface [polypeptide binding]; other site 694569000029 N-terminal domain interface [polypeptide binding]; other site 694569000030 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 694569000031 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 694569000032 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 694569000033 putative dimer interface [polypeptide binding]; other site 694569000034 putative anticodon binding site; other site 694569000035 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 694569000036 homodimer interface [polypeptide binding]; other site 694569000037 motif 1; other site 694569000038 motif 2; other site 694569000039 active site 694569000040 motif 3; other site 694569000041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 694569000042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 694569000043 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 694569000044 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 694569000045 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 694569000046 putative N- and C-terminal domain interface [polypeptide binding]; other site 694569000047 putative active site [active] 694569000048 putative MgATP binding site [chemical binding]; other site 694569000049 catalytic site [active] 694569000050 metal binding site [ion binding]; metal-binding site 694569000051 putative carbohydrate binding site [chemical binding]; other site 694569000052 transcriptional regulator LsrR; Provisional; Region: PRK15418 694569000053 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 694569000054 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 694569000055 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 694569000056 Walker A/P-loop; other site 694569000057 ATP binding site [chemical binding]; other site 694569000058 Q-loop/lid; other site 694569000059 ABC transporter signature motif; other site 694569000060 Walker B; other site 694569000061 D-loop; other site 694569000062 H-loop/switch region; other site 694569000063 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 694569000064 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569000065 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569000066 TM-ABC transporter signature motif; other site 694569000067 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569000068 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569000069 TM-ABC transporter signature motif; other site 694569000070 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 694569000071 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 694569000072 ligand binding site [chemical binding]; other site 694569000073 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 694569000074 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 694569000075 putative active site; other site 694569000076 catalytic residue [active] 694569000077 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 694569000078 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 694569000079 pyruvate kinase; Provisional; Region: PRK05826 694569000080 active site 694569000081 domain interfaces; other site 694569000082 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 694569000083 dimer interface [polypeptide binding]; other site 694569000084 putative radical transfer pathway; other site 694569000085 diiron center [ion binding]; other site 694569000086 tyrosyl radical; other site 694569000087 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 694569000088 Class I ribonucleotide reductase; Region: RNR_I; cd01679 694569000089 active site 694569000090 dimer interface [polypeptide binding]; other site 694569000091 catalytic residues [active] 694569000092 effector binding site; other site 694569000093 R2 peptide binding site; other site 694569000094 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 694569000095 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 694569000096 substrate binding site [chemical binding]; other site 694569000097 active site 694569000098 catalytic residues [active] 694569000099 heterodimer interface [polypeptide binding]; other site 694569000100 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 694569000101 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 694569000102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569000103 catalytic residue [active] 694569000104 malonic semialdehyde reductase; Provisional; Region: PRK10538 694569000105 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 694569000106 putative NAD(P) binding site [chemical binding]; other site 694569000107 homotetramer interface [polypeptide binding]; other site 694569000108 homodimer interface [polypeptide binding]; other site 694569000109 active site 694569000110 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 694569000111 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694569000112 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694569000113 ligand-binding site [chemical binding]; other site 694569000114 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 694569000115 oxaloacetate decarboxylase; Provisional; Region: PRK14040 694569000116 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 694569000117 active site 694569000118 catalytic residues [active] 694569000119 metal binding site [ion binding]; metal-binding site 694569000120 homodimer binding site [polypeptide binding]; other site 694569000121 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694569000122 carboxyltransferase (CT) interaction site; other site 694569000123 biotinylation site [posttranslational modification]; other site 694569000124 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 694569000125 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 694569000126 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 694569000127 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 694569000128 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 694569000129 active site 694569000130 ribulose/triose binding site [chemical binding]; other site 694569000131 phosphate binding site [ion binding]; other site 694569000132 substrate (anthranilate) binding pocket [chemical binding]; other site 694569000133 product (indole) binding pocket [chemical binding]; other site 694569000134 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 694569000135 active site 694569000136 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 694569000137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569000138 non-specific DNA binding site [nucleotide binding]; other site 694569000139 salt bridge; other site 694569000140 sequence-specific DNA binding site [nucleotide binding]; other site 694569000141 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 694569000142 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 694569000143 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 694569000144 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 694569000145 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 694569000146 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 694569000147 Glutamine amidotransferase class-I; Region: GATase; pfam00117 694569000148 glutamine binding [chemical binding]; other site 694569000149 catalytic triad [active] 694569000150 anthranilate synthase component I; Provisional; Region: PRK13564 694569000151 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 694569000152 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 694569000153 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 694569000154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569000155 active site 694569000156 motif I; other site 694569000157 motif II; other site 694569000158 KpsF/GutQ family protein; Region: kpsF; TIGR00393 694569000159 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 694569000160 putative active site [active] 694569000161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 694569000162 heat shock protein HtpX; Provisional; Region: PRK05457 694569000163 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 694569000164 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 694569000165 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 694569000166 dimer interface [polypeptide binding]; other site 694569000167 motif 1; other site 694569000168 active site 694569000169 motif 2; other site 694569000170 motif 3; other site 694569000171 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 694569000172 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 694569000173 putative tRNA-binding site [nucleotide binding]; other site 694569000174 B3/4 domain; Region: B3_4; pfam03483 694569000175 tRNA synthetase B5 domain; Region: B5; smart00874 694569000176 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 694569000177 dimer interface [polypeptide binding]; other site 694569000178 motif 1; other site 694569000179 motif 3; other site 694569000180 motif 2; other site 694569000181 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 694569000182 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694569000183 IHF dimer interface [polypeptide binding]; other site 694569000184 IHF - DNA interface [nucleotide binding]; other site 694569000185 NlpC/P60 family; Region: NLPC_P60; pfam00877 694569000186 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694569000187 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 694569000188 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 694569000189 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694569000190 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 694569000191 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 694569000192 Walker A/P-loop; other site 694569000193 ATP binding site [chemical binding]; other site 694569000194 Q-loop/lid; other site 694569000195 ABC transporter signature motif; other site 694569000196 Walker B; other site 694569000197 D-loop; other site 694569000198 H-loop/switch region; other site 694569000199 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 694569000200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569000201 Walker A/P-loop; other site 694569000202 ATP binding site [chemical binding]; other site 694569000203 Q-loop/lid; other site 694569000204 ABC transporter signature motif; other site 694569000205 Walker B; other site 694569000206 D-loop; other site 694569000207 H-loop/switch region; other site 694569000208 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 694569000209 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694569000210 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694569000211 HlyD family secretion protein; Region: HlyD_3; pfam13437 694569000212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694569000213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694569000214 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 694569000215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694569000216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569000217 homodimer interface [polypeptide binding]; other site 694569000218 catalytic residue [active] 694569000219 aminopeptidase N; Provisional; Region: pepN; PRK14015 694569000220 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 694569000221 active site 694569000222 Zn binding site [ion binding]; other site 694569000223 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 694569000224 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 694569000225 quinone interaction residues [chemical binding]; other site 694569000226 active site 694569000227 catalytic residues [active] 694569000228 FMN binding site [chemical binding]; other site 694569000229 substrate binding site [chemical binding]; other site 694569000230 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 694569000231 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 694569000232 active site 694569000233 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 694569000234 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 694569000235 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 694569000236 active site 694569000237 interdomain interaction site; other site 694569000238 putative metal-binding site [ion binding]; other site 694569000239 nucleotide binding site [chemical binding]; other site 694569000240 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 694569000241 domain I; other site 694569000242 DNA binding groove [nucleotide binding] 694569000243 phosphate binding site [ion binding]; other site 694569000244 domain II; other site 694569000245 domain III; other site 694569000246 nucleotide binding site [chemical binding]; other site 694569000247 catalytic site [active] 694569000248 domain IV; other site 694569000249 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 694569000250 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 694569000251 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 694569000252 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 694569000253 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 694569000254 universal stress protein UspE; Provisional; Region: PRK11175 694569000255 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694569000256 Ligand Binding Site [chemical binding]; other site 694569000257 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694569000258 Ligand Binding Site [chemical binding]; other site 694569000259 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 694569000260 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694569000261 ligand binding site [chemical binding]; other site 694569000262 flexible hinge region; other site 694569000263 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 694569000264 putative switch regulator; other site 694569000265 non-specific DNA interactions [nucleotide binding]; other site 694569000266 DNA binding site [nucleotide binding] 694569000267 sequence specific DNA binding site [nucleotide binding]; other site 694569000268 putative cAMP binding site [chemical binding]; other site 694569000269 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 694569000270 Ferritin-like domain; Region: Ferritin; pfam00210 694569000271 ferroxidase diiron center [ion binding]; other site 694569000272 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 694569000273 Ferritin-like domain; Region: Ferritin; pfam00210 694569000274 ferroxidase diiron center [ion binding]; other site 694569000275 exonuclease I; Provisional; Region: sbcB; PRK11779 694569000276 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 694569000277 active site 694569000278 catalytic site [active] 694569000279 substrate binding site [chemical binding]; other site 694569000280 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 694569000281 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 694569000282 P-loop containing region of AAA domain; Region: AAA_29; cl17516 694569000283 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 694569000284 condesin subunit E; Provisional; Region: PRK05256 694569000285 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 694569000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569000287 putative substrate translocation pore; other site 694569000288 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694569000289 putative acyl-acceptor binding pocket; other site 694569000290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694569000291 acyl-activating enzyme (AAE) consensus motif; other site 694569000292 AMP binding site [chemical binding]; other site 694569000293 active site 694569000294 CoA binding site [chemical binding]; other site 694569000295 condesin subunit F; Provisional; Region: PRK05260 694569000296 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 694569000297 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 694569000298 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 694569000299 5S rRNA interface [nucleotide binding]; other site 694569000300 CTC domain interface [polypeptide binding]; other site 694569000301 L16 interface [polypeptide binding]; other site 694569000302 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 694569000303 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 694569000304 glycogen phosphorylase; Provisional; Region: PRK14986 694569000305 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 694569000306 homodimer interface [polypeptide binding]; other site 694569000307 active site pocket [active] 694569000308 glycogen synthase; Provisional; Region: glgA; PRK00654 694569000309 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 694569000310 ADP-binding pocket [chemical binding]; other site 694569000311 homodimer interface [polypeptide binding]; other site 694569000312 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 694569000313 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 694569000314 ligand binding site; other site 694569000315 oligomer interface; other site 694569000316 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 694569000317 N-terminal domain interface [polypeptide binding]; other site 694569000318 sulfate 1 binding site; other site 694569000319 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 694569000320 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 694569000321 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 694569000322 active site 694569000323 catalytic site [active] 694569000324 glycogen branching enzyme; Provisional; Region: PRK05402 694569000325 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 694569000326 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 694569000327 active site 694569000328 catalytic site [active] 694569000329 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 694569000330 ABC transporter ATPase component; Reviewed; Region: PRK11147 694569000331 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569000332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569000333 ABC transporter; Region: ABC_tran_2; pfam12848 694569000334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569000335 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 694569000336 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 694569000337 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 694569000338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 694569000339 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 694569000340 LrgB-like family; Region: LrgB; cl00596 694569000341 hypothetical protein; Provisional; Region: PRK01821 694569000342 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 694569000343 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694569000344 active site 694569000345 DNA binding site [nucleotide binding] 694569000346 Int/Topo IB signature motif; other site 694569000347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569000348 non-specific DNA binding site [nucleotide binding]; other site 694569000349 salt bridge; other site 694569000350 sequence-specific DNA binding site [nucleotide binding]; other site 694569000351 Helix-turn-helix domain; Region: HTH_38; pfam13936 694569000352 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 694569000353 Integrase core domain; Region: rve; pfam00665 694569000354 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 694569000355 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 694569000356 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 694569000357 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 694569000358 Fic/DOC family; Region: Fic; pfam02661 694569000359 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 694569000360 active site pocket [active] 694569000361 oxyanion hole [active] 694569000362 catalytic triad [active] 694569000363 active site nucleophile [active] 694569000364 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 694569000365 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 694569000366 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 694569000367 Ligand Binding Site [chemical binding]; other site 694569000368 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694569000369 active site residue [active] 694569000370 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 694569000371 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 694569000372 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 694569000373 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 694569000374 molybdopterin cofactor binding site [chemical binding]; other site 694569000375 substrate binding site [chemical binding]; other site 694569000376 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 694569000377 molybdopterin cofactor binding site; other site 694569000378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 694569000379 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 694569000380 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 694569000381 transmembrane helices; other site 694569000382 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 694569000383 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 694569000384 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 694569000385 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 694569000386 dimerization interface 3.5A [polypeptide binding]; other site 694569000387 active site 694569000388 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 694569000389 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 694569000390 23S rRNA interface [nucleotide binding]; other site 694569000391 L3 interface [polypeptide binding]; other site 694569000392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569000393 S-adenosylmethionine binding site [chemical binding]; other site 694569000394 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 694569000395 AAA domain; Region: AAA_30; pfam13604 694569000396 Family description; Region: UvrD_C_2; pfam13538 694569000397 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 694569000398 Family description; Region: UvrD_C_2; pfam13538 694569000399 DsrE/DsrF-like family; Region: DrsE; cl00672 694569000400 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 694569000401 active site 1 [active] 694569000402 dimer interface [polypeptide binding]; other site 694569000403 active site 2 [active] 694569000404 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 694569000405 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 694569000406 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 694569000407 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 694569000408 DNA-binding site [nucleotide binding]; DNA binding site 694569000409 RNA-binding motif; other site 694569000410 Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701 694569000411 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 694569000412 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694569000413 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 694569000414 probable active site [active] 694569000415 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 694569000416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 694569000417 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 694569000418 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 694569000419 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 694569000420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694569000421 active site 694569000422 phosphorylation site [posttranslational modification] 694569000423 intermolecular recognition site; other site 694569000424 dimerization interface [polypeptide binding]; other site 694569000425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 694569000426 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 694569000427 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 694569000428 HAMP domain; Region: HAMP; pfam00672 694569000429 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 694569000430 Mg2+ binding site [ion binding]; other site 694569000431 G-X-G motif; other site 694569000432 HTH-like domain; Region: HTH_21; pfam13276 694569000433 Integrase core domain; Region: rve; pfam00665 694569000434 Integrase core domain; Region: rve_2; pfam13333 694569000435 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 694569000436 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 694569000437 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 694569000438 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 694569000439 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 694569000440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569000441 Walker A/P-loop; other site 694569000442 ATP binding site [chemical binding]; other site 694569000443 Q-loop/lid; other site 694569000444 ABC transporter signature motif; other site 694569000445 Walker B; other site 694569000446 D-loop; other site 694569000447 H-loop/switch region; other site 694569000448 TOBE domain; Region: TOBE_2; pfam08402 694569000449 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 694569000450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569000451 dimer interface [polypeptide binding]; other site 694569000452 conserved gate region; other site 694569000453 putative PBP binding loops; other site 694569000454 ABC-ATPase subunit interface; other site 694569000455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569000456 dimer interface [polypeptide binding]; other site 694569000457 conserved gate region; other site 694569000458 putative PBP binding loops; other site 694569000459 ABC-ATPase subunit interface; other site 694569000460 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 694569000461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569000462 Walker A/P-loop; other site 694569000463 ATP binding site [chemical binding]; other site 694569000464 Q-loop/lid; other site 694569000465 ABC transporter signature motif; other site 694569000466 Walker B; other site 694569000467 D-loop; other site 694569000468 H-loop/switch region; other site 694569000469 TOBE domain; Region: TOBE_2; pfam08402 694569000470 Protein of unknown function, DUF462; Region: DUF462; cl01190 694569000471 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 694569000472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569000473 Walker A motif; other site 694569000474 ATP binding site [chemical binding]; other site 694569000475 Walker B motif; other site 694569000476 arginine finger; other site 694569000477 Peptidase family M41; Region: Peptidase_M41; pfam01434 694569000478 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 694569000479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569000480 S-adenosylmethionine binding site [chemical binding]; other site 694569000481 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 694569000482 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 694569000483 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 694569000484 putative active site [active] 694569000485 putative substrate binding site [chemical binding]; other site 694569000486 putative cosubstrate binding site; other site 694569000487 catalytic site [active] 694569000488 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 694569000489 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 694569000490 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 694569000491 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569000492 Sel1-like repeats; Region: SEL1; smart00671 694569000493 Sel1 repeat; Region: Sel1; cl02723 694569000494 Sel1-like repeats; Region: SEL1; smart00671 694569000495 Sel1 repeat; Region: Sel1; cl02723 694569000496 YwiC-like protein; Region: YwiC; pfam14256 694569000497 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 694569000498 homotrimer interaction site [polypeptide binding]; other site 694569000499 putative active site [active] 694569000500 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 694569000501 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 694569000502 Ligand binding site; other site 694569000503 Putative Catalytic site; other site 694569000504 DXD motif; other site 694569000505 hypothetical protein; Provisional; Region: PRK05421 694569000506 putative catalytic site [active] 694569000507 putative metal binding site [ion binding]; other site 694569000508 putative phosphate binding site [ion binding]; other site 694569000509 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 694569000510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569000511 Walker A motif; other site 694569000512 ATP binding site [chemical binding]; other site 694569000513 Walker B motif; other site 694569000514 DNA polymerase III subunit delta'; Validated; Region: PRK08485 694569000515 arginine finger; other site 694569000516 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 694569000517 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 694569000518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569000519 active site 694569000520 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 694569000521 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 694569000522 putative acyl-acceptor binding pocket; other site 694569000523 hypothetical protein; Provisional; Region: PRK10621 694569000524 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694569000525 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 694569000526 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 694569000527 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 694569000528 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 694569000529 Tetramer interface [polypeptide binding]; other site 694569000530 active site 694569000531 FMN-binding site [chemical binding]; other site 694569000532 hypothetical protein; Provisional; Region: PRK11281 694569000533 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 694569000534 Mechanosensitive ion channel; Region: MS_channel; pfam00924 694569000535 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 694569000536 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 694569000537 acyl-activating enzyme (AAE) consensus motif; other site 694569000538 putative AMP binding site [chemical binding]; other site 694569000539 putative active site [active] 694569000540 putative CoA binding site [chemical binding]; other site 694569000541 replication initiation regulator SeqA; Provisional; Region: PRK11187 694569000542 acyl-CoA esterase; Provisional; Region: PRK10673 694569000543 PGAP1-like protein; Region: PGAP1; pfam07819 694569000544 flavodoxin FldA; Validated; Region: PRK09267 694569000545 ferric uptake regulator; Provisional; Region: fur; PRK09462 694569000546 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 694569000547 metal binding site 2 [ion binding]; metal-binding site 694569000548 putative DNA binding helix; other site 694569000549 metal binding site 1 [ion binding]; metal-binding site 694569000550 dimer interface [polypeptide binding]; other site 694569000551 structural Zn2+ binding site [ion binding]; other site 694569000552 DNA gyrase subunit A; Validated; Region: PRK05560 694569000553 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 694569000554 CAP-like domain; other site 694569000555 active site 694569000556 primary dimer interface [polypeptide binding]; other site 694569000557 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694569000558 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694569000559 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694569000560 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694569000561 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694569000562 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 694569000563 Invasion gene expression up-regulator, SirB; Region: SirB; cl01184 694569000564 translation initiation factor Sui1; Validated; Region: PRK06824 694569000565 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 694569000566 putative rRNA binding site [nucleotide binding]; other site 694569000567 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 694569000568 active site 694569000569 dimer interface [polypeptide binding]; other site 694569000570 tetratricopeptide repeat protein; Provisional; Region: PRK11788 694569000571 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 694569000572 Predicted membrane protein [Function unknown]; Region: COG3771 694569000573 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694569000574 IHF dimer interface [polypeptide binding]; other site 694569000575 IHF - DNA interface [nucleotide binding]; other site 694569000576 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 694569000577 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 694569000578 RNA binding site [nucleotide binding]; other site 694569000579 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 694569000580 RNA binding site [nucleotide binding]; other site 694569000581 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 694569000582 RNA binding site [nucleotide binding]; other site 694569000583 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 694569000584 RNA binding site [nucleotide binding]; other site 694569000585 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 694569000586 RNA binding site [nucleotide binding]; other site 694569000587 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694569000588 RNA binding site [nucleotide binding]; other site 694569000589 cytidylate kinase; Provisional; Region: cmk; PRK00023 694569000590 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 694569000591 CMP-binding site; other site 694569000592 The sites determining sugar specificity; other site 694569000593 Protein of unknown function (DUF535); Region: DUF535; pfam04393 694569000594 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694569000595 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694569000596 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 694569000597 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 694569000598 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694569000599 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 694569000600 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 694569000601 AzlC protein; Region: AzlC; cl00570 694569000602 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 694569000603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569000604 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 694569000605 putative dimerization interface [polypeptide binding]; other site 694569000606 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 694569000607 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 694569000608 THF binding site; other site 694569000609 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 694569000610 substrate binding site [chemical binding]; other site 694569000611 THF binding site; other site 694569000612 zinc-binding site [ion binding]; other site 694569000613 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 694569000614 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 694569000615 Uncharacterized conserved protein [Function unknown]; Region: COG1479 694569000616 Protein of unknown function DUF262; Region: DUF262; pfam03235 694569000617 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 694569000618 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 694569000619 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 694569000620 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 694569000621 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 694569000622 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 694569000623 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 694569000624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 694569000625 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 694569000626 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 694569000627 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 694569000628 metal binding triad; other site 694569000629 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 694569000630 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 694569000631 metal binding triad; other site 694569000632 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 694569000633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569000634 non-specific DNA binding site [nucleotide binding]; other site 694569000635 salt bridge; other site 694569000636 sequence-specific DNA binding site [nucleotide binding]; other site 694569000637 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 694569000638 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 694569000639 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 694569000640 G1 box; other site 694569000641 putative GEF interaction site [polypeptide binding]; other site 694569000642 GTP/Mg2+ binding site [chemical binding]; other site 694569000643 Switch I region; other site 694569000644 G2 box; other site 694569000645 G3 box; other site 694569000646 Switch II region; other site 694569000647 G4 box; other site 694569000648 G5 box; other site 694569000649 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 694569000650 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 694569000651 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 694569000652 putative NAD(P) binding site [chemical binding]; other site 694569000653 argininosuccinate synthase; Validated; Region: PRK05370 694569000654 argininosuccinate synthase; Provisional; Region: PRK13820 694569000655 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 694569000656 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 694569000657 sensor protein QseC; Provisional; Region: PRK10337 694569000658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694569000659 dimer interface [polypeptide binding]; other site 694569000660 phosphorylation site [posttranslational modification] 694569000661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569000662 ATP binding site [chemical binding]; other site 694569000663 Mg2+ binding site [ion binding]; other site 694569000664 G-X-G motif; other site 694569000665 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 694569000666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694569000667 active site 694569000668 phosphorylation site [posttranslational modification] 694569000669 intermolecular recognition site; other site 694569000670 dimerization interface [polypeptide binding]; other site 694569000671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694569000672 DNA binding site [nucleotide binding] 694569000673 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 694569000674 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 694569000675 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 694569000676 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 694569000677 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 694569000678 active site 694569000679 metal binding site [ion binding]; metal-binding site 694569000680 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 694569000681 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 694569000682 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 694569000683 putative ligand binding residues [chemical binding]; other site 694569000684 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 694569000685 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569000686 ABC-ATPase subunit interface; other site 694569000687 dimer interface [polypeptide binding]; other site 694569000688 putative PBP binding regions; other site 694569000689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569000690 ABC-ATPase subunit interface; other site 694569000691 dimer interface [polypeptide binding]; other site 694569000692 putative PBP binding regions; other site 694569000693 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 694569000694 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694569000695 Walker A/P-loop; other site 694569000696 ATP binding site [chemical binding]; other site 694569000697 Q-loop/lid; other site 694569000698 ABC transporter signature motif; other site 694569000699 Walker B; other site 694569000700 D-loop; other site 694569000701 H-loop/switch region; other site 694569000702 putative peptidase; Provisional; Region: PRK11649 694569000703 Peptidase family M23; Region: Peptidase_M23; pfam01551 694569000704 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 694569000705 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 694569000706 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 694569000707 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569000708 ABC-ATPase subunit interface; other site 694569000709 dimer interface [polypeptide binding]; other site 694569000710 putative PBP binding regions; other site 694569000711 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 694569000712 Na2 binding site [ion binding]; other site 694569000713 putative substrate binding site 1 [chemical binding]; other site 694569000714 Na binding site 1 [ion binding]; other site 694569000715 putative substrate binding site 2 [chemical binding]; other site 694569000716 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694569000717 helix-hairpin-helix signature motif; other site 694569000718 substrate binding pocket [chemical binding]; other site 694569000719 active site 694569000720 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 694569000721 electron transport complex RsxE subunit; Provisional; Region: PRK12405 694569000722 electron transport complex protein RnfG; Validated; Region: PRK01908 694569000723 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 694569000724 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 694569000725 SLBB domain; Region: SLBB; pfam10531 694569000726 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694569000727 electron transport complex protein RnfB; Provisional; Region: PRK05113 694569000728 Putative Fe-S cluster; Region: FeS; pfam04060 694569000729 4Fe-4S binding domain; Region: Fer4; pfam00037 694569000730 electron transport complex protein RsxA; Provisional; Region: PRK05151 694569000731 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 694569000732 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 694569000733 putative NAD(P) binding site [chemical binding]; other site 694569000734 putative active site [active] 694569000735 arginine repressor; Provisional; Region: PRK05066 694569000736 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 694569000737 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 694569000738 malate dehydrogenase; Provisional; Region: PRK05086 694569000739 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 694569000740 NAD binding site [chemical binding]; other site 694569000741 dimerization interface [polypeptide binding]; other site 694569000742 Substrate binding site [chemical binding]; other site 694569000743 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 694569000744 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 694569000745 homodimer interface [polypeptide binding]; other site 694569000746 substrate-cofactor binding pocket; other site 694569000747 catalytic residue [active] 694569000748 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 694569000749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569000750 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 694569000751 dimerization interface [polypeptide binding]; other site 694569000752 substrate binding pocket [chemical binding]; other site 694569000753 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 694569000754 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 694569000755 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 694569000756 ATP cone domain; Region: ATP-cone; pfam03477 694569000757 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 694569000758 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 694569000759 catalytic motif [active] 694569000760 Zn binding site [ion binding]; other site 694569000761 RibD C-terminal domain; Region: RibD_C; cl17279 694569000762 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 694569000763 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 694569000764 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 694569000765 protein binding site [polypeptide binding]; other site 694569000766 5'-nucleotidase; Provisional; Region: PRK03826 694569000767 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 694569000768 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 694569000769 transmembrane helices; other site 694569000770 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 694569000771 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 694569000772 molybdenum-pterin binding domain; Region: Mop; TIGR00638 694569000773 TOBE domain; Region: TOBE; pfam03459 694569000774 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 694569000775 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 694569000776 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 694569000777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569000778 dimer interface [polypeptide binding]; other site 694569000779 conserved gate region; other site 694569000780 putative PBP binding loops; other site 694569000781 ABC-ATPase subunit interface; other site 694569000782 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 694569000783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569000784 Walker A/P-loop; other site 694569000785 ATP binding site [chemical binding]; other site 694569000786 Q-loop/lid; other site 694569000787 ABC transporter signature motif; other site 694569000788 Walker B; other site 694569000789 D-loop; other site 694569000790 H-loop/switch region; other site 694569000791 TOBE domain; Region: TOBE; cl01440 694569000792 multifunctional aminopeptidase A; Provisional; Region: PRK00913 694569000793 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 694569000794 interface (dimer of trimers) [polypeptide binding]; other site 694569000795 Substrate-binding/catalytic site; other site 694569000796 Zn-binding sites [ion binding]; other site 694569000797 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 694569000798 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694569000799 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 694569000800 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 694569000801 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 694569000802 FAD binding site [chemical binding]; other site 694569000803 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 694569000804 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 694569000805 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 694569000806 shikimate binding site; other site 694569000807 NAD(P) binding site [chemical binding]; other site 694569000808 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 694569000809 dimerization interface [polypeptide binding]; other site 694569000810 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 694569000811 ATP binding site [chemical binding]; other site 694569000812 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 694569000813 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 694569000814 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 694569000815 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 694569000816 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 694569000817 Walker A/P-loop; other site 694569000818 ATP binding site [chemical binding]; other site 694569000819 Q-loop/lid; other site 694569000820 ABC transporter signature motif; other site 694569000821 Walker B; other site 694569000822 D-loop; other site 694569000823 H-loop/switch region; other site 694569000824 cobalt transport protein CbiM; Validated; Region: PRK06265 694569000825 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 694569000826 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 694569000827 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 694569000828 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 694569000829 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 694569000830 catalytic residues [active] 694569000831 hinge region; other site 694569000832 alpha helical domain; other site 694569000833 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 694569000834 DHH family; Region: DHH; pfam01368 694569000835 DHHA1 domain; Region: DHHA1; pfam02272 694569000836 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 694569000837 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 694569000838 dimerization domain [polypeptide binding]; other site 694569000839 dimer interface [polypeptide binding]; other site 694569000840 catalytic residues [active] 694569000841 peptide chain release factor 2; Provisional; Region: PRK08787 694569000842 This domain is found in peptide chain release factors; Region: PCRF; smart00937 694569000843 RF-1 domain; Region: RF-1; pfam00472 694569000844 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 694569000845 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 694569000846 dimer interface [polypeptide binding]; other site 694569000847 putative anticodon binding site; other site 694569000848 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 694569000849 motif 1; other site 694569000850 active site 694569000851 motif 2; other site 694569000852 motif 3; other site 694569000853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569000854 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 694569000855 putative substrate translocation pore; other site 694569000856 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 694569000857 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 694569000858 active site 694569000859 dimerization interface [polypeptide binding]; other site 694569000860 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 694569000861 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569000862 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569000863 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569000864 putative active site [active] 694569000865 catalytic site [active] 694569000866 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 694569000867 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569000868 putative active site [active] 694569000869 catalytic site [active] 694569000870 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569000871 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569000872 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569000873 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 694569000874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694569000875 DNA binding site [nucleotide binding] 694569000876 domain linker motif; other site 694569000877 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 694569000878 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 694569000879 putative active site [active] 694569000880 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 694569000881 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 694569000882 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 694569000883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694569000884 DNA binding site [nucleotide binding] 694569000885 domain linker motif; other site 694569000886 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 694569000887 dimerization interface [polypeptide binding]; other site 694569000888 ligand binding site [chemical binding]; other site 694569000889 dsDNA-mimic protein; Reviewed; Region: PRK05094 694569000890 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 694569000891 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 694569000892 trimer interface [polypeptide binding]; other site 694569000893 active site 694569000894 substrate binding site [chemical binding]; other site 694569000895 CoA binding site [chemical binding]; other site 694569000896 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 694569000897 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569000898 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 694569000899 substrate binding site [chemical binding]; other site 694569000900 dimerization interface [polypeptide binding]; other site 694569000901 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 694569000902 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569000903 RNA binding surface [nucleotide binding]; other site 694569000904 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 694569000905 probable active site [active] 694569000906 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 694569000907 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 694569000908 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 694569000909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694569000910 prephenate dehydrogenase; Validated; Region: PRK08507 694569000911 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 694569000912 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 694569000913 tandem repeat interface [polypeptide binding]; other site 694569000914 oligomer interface [polypeptide binding]; other site 694569000915 active site residues [active] 694569000916 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 694569000917 tandem repeat interface [polypeptide binding]; other site 694569000918 oligomer interface [polypeptide binding]; other site 694569000919 active site residues [active] 694569000920 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 694569000921 putative FMN binding site [chemical binding]; other site 694569000922 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 694569000923 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694569000924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694569000925 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 694569000926 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 694569000927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694569000928 E3 interaction surface; other site 694569000929 lipoyl attachment site [posttranslational modification]; other site 694569000930 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694569000931 E3 interaction surface; other site 694569000932 lipoyl attachment site [posttranslational modification]; other site 694569000933 e3 binding domain; Region: E3_binding; pfam02817 694569000934 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 694569000935 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 694569000936 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 694569000937 dimer interface [polypeptide binding]; other site 694569000938 TPP-binding site [chemical binding]; other site 694569000939 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 694569000940 tellurite resistance protein TehB; Provisional; Region: PRK12335 694569000941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569000942 S-adenosylmethionine binding site [chemical binding]; other site 694569000943 transcriptional regulator MalT; Provisional; Region: PRK04841 694569000944 AAA ATPase domain; Region: AAA_16; pfam13191 694569000945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694569000946 DNA binding residues [nucleotide binding] 694569000947 dimerization interface [polypeptide binding]; other site 694569000948 maltodextrin phosphorylase; Provisional; Region: PRK14985 694569000949 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 694569000950 active site pocket [active] 694569000951 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 694569000952 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 694569000953 Colicin V production protein; Region: Colicin_V; cl00567 694569000954 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 694569000955 hypothetical protein; Provisional; Region: PRK01816 694569000956 propionate/acetate kinase; Provisional; Region: PRK12379 694569000957 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 694569000958 phosphate acetyltransferase; Reviewed; Region: PRK05632 694569000959 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 694569000960 DRTGG domain; Region: DRTGG; pfam07085 694569000961 phosphate acetyltransferase; Region: pta; TIGR00651 694569000962 Cupin domain; Region: Cupin_2; cl17218 694569000963 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 694569000964 catalytic center binding site [active] 694569000965 ATP binding site [chemical binding]; other site 694569000966 poly(A) polymerase; Region: pcnB; TIGR01942 694569000967 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 694569000968 active site 694569000969 NTP binding site [chemical binding]; other site 694569000970 metal binding triad [ion binding]; metal-binding site 694569000971 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 694569000972 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 694569000973 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 694569000974 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 694569000975 Competence protein; Region: Competence; pfam03772 694569000976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 694569000977 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 694569000978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694569000979 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 694569000980 Walker A/P-loop; other site 694569000981 ATP binding site [chemical binding]; other site 694569000982 Q-loop/lid; other site 694569000983 ABC transporter signature motif; other site 694569000984 Walker B; other site 694569000985 D-loop; other site 694569000986 H-loop/switch region; other site 694569000987 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 694569000988 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 694569000989 Uncharacterized conserved protein [Function unknown]; Region: COG2835 694569000990 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 694569000991 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 694569000992 oligomer interface; other site 694569000993 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 694569000994 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 694569000995 GIY-YIG motif/motif A; other site 694569000996 active site 694569000997 catalytic site [active] 694569000998 putative DNA binding site [nucleotide binding]; other site 694569000999 metal binding site [ion binding]; metal-binding site 694569001000 UvrB/uvrC motif; Region: UVR; pfam02151 694569001001 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 694569001002 Helix-hairpin-helix motif; Region: HHH; pfam00633 694569001003 hypothetical protein; Provisional; Region: PRK11622 694569001004 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 694569001005 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 694569001006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569001007 dimer interface [polypeptide binding]; other site 694569001008 conserved gate region; other site 694569001009 putative PBP binding loops; other site 694569001010 ABC-ATPase subunit interface; other site 694569001011 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 694569001012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569001013 dimer interface [polypeptide binding]; other site 694569001014 conserved gate region; other site 694569001015 putative PBP binding loops; other site 694569001016 ABC-ATPase subunit interface; other site 694569001017 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 694569001018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569001019 Walker A/P-loop; other site 694569001020 ATP binding site [chemical binding]; other site 694569001021 Q-loop/lid; other site 694569001022 ABC transporter signature motif; other site 694569001023 Walker B; other site 694569001024 D-loop; other site 694569001025 H-loop/switch region; other site 694569001026 selenophosphate synthetase; Provisional; Region: PRK00943 694569001027 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 694569001028 dimerization interface [polypeptide binding]; other site 694569001029 putative ATP binding site [chemical binding]; other site 694569001030 Fic family protein [Function unknown]; Region: COG3177 694569001031 Fic/DOC family; Region: Fic; pfam02661 694569001032 Betaherpesvirus immediate-early glycoprotein UL37; Region: Herpes_UL37_2; cl17390 694569001033 BRO family, N-terminal domain; Region: Bro-N; cl10591 694569001034 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 694569001035 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 694569001036 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 694569001037 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 694569001038 ligand binding site [chemical binding]; other site 694569001039 homodimer interface [polypeptide binding]; other site 694569001040 NAD(P) binding site [chemical binding]; other site 694569001041 trimer interface B [polypeptide binding]; other site 694569001042 trimer interface A [polypeptide binding]; other site 694569001043 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 694569001044 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 694569001045 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 694569001046 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 694569001047 active site 694569001048 HIGH motif; other site 694569001049 dimer interface [polypeptide binding]; other site 694569001050 KMSKS motif; other site 694569001051 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569001052 RNA binding surface [nucleotide binding]; other site 694569001053 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 694569001054 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 694569001055 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 694569001056 RNA binding site [nucleotide binding]; other site 694569001057 active site 694569001058 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 694569001059 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 694569001060 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 694569001061 translation initiation factor IF-2; Region: IF-2; TIGR00487 694569001062 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 694569001063 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 694569001064 G1 box; other site 694569001065 putative GEF interaction site [polypeptide binding]; other site 694569001066 GTP/Mg2+ binding site [chemical binding]; other site 694569001067 Switch I region; other site 694569001068 G2 box; other site 694569001069 G3 box; other site 694569001070 Switch II region; other site 694569001071 G4 box; other site 694569001072 G5 box; other site 694569001073 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 694569001074 Translation-initiation factor 2; Region: IF-2; pfam11987 694569001075 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 694569001076 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 694569001077 NusA N-terminal domain; Region: NusA_N; pfam08529 694569001078 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 694569001079 RNA binding site [nucleotide binding]; other site 694569001080 homodimer interface [polypeptide binding]; other site 694569001081 NusA-like KH domain; Region: KH_5; pfam13184 694569001082 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 694569001083 G-X-X-G motif; other site 694569001084 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 694569001085 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 694569001086 ribosome maturation protein RimP; Reviewed; Region: PRK00092 694569001087 Sm and related proteins; Region: Sm_like; cl00259 694569001088 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 694569001089 putative oligomer interface [polypeptide binding]; other site 694569001090 putative RNA binding site [nucleotide binding]; other site 694569001091 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 694569001092 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 694569001093 Mg++ binding site [ion binding]; other site 694569001094 putative catalytic motif [active] 694569001095 substrate binding site [chemical binding]; other site 694569001096 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 694569001097 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694569001098 inhibitor-cofactor binding pocket; inhibition site 694569001099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569001100 catalytic residue [active] 694569001101 PII uridylyl-transferase; Provisional; Region: glnD; PRK01759 694569001102 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 694569001103 metal binding triad; other site 694569001104 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 694569001105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694569001106 Zn2+ binding site [ion binding]; other site 694569001107 Mg2+ binding site [ion binding]; other site 694569001108 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 694569001109 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 694569001110 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 694569001111 active site 694569001112 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 694569001113 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 694569001114 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 694569001115 Transglycosylase; Region: Transgly; pfam00912 694569001116 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 694569001117 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 694569001118 Uncharacterized protein probably involved in high-affinity Fe2+ transport [Inorganic ion transport and metabolism]; Region: Tpd; COG3470 694569001119 Predicted membrane protein [Function unknown]; Region: COG4393 694569001120 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 694569001121 Uncharacterized conserved protein [Function unknown]; Region: COG3350 694569001122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694569001123 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 694569001124 FtsX-like permease family; Region: FtsX; pfam02687 694569001125 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 694569001126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694569001127 FtsX-like permease family; Region: FtsX; pfam02687 694569001128 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 694569001129 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694569001130 Walker A/P-loop; other site 694569001131 ATP binding site [chemical binding]; other site 694569001132 Q-loop/lid; other site 694569001133 ABC transporter signature motif; other site 694569001134 Walker B; other site 694569001135 D-loop; other site 694569001136 H-loop/switch region; other site 694569001137 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694569001138 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694569001139 catalytic residues [active] 694569001140 Cytochrome c; Region: Cytochrom_C; cl11414 694569001141 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 694569001142 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 694569001143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569001144 motif II; other site 694569001145 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 694569001146 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 694569001147 P-loop; other site 694569001148 Magnesium ion binding site [ion binding]; other site 694569001149 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 694569001150 Magnesium ion binding site [ion binding]; other site 694569001151 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 694569001152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569001153 ATP binding site [chemical binding]; other site 694569001154 putative Mg++ binding site [ion binding]; other site 694569001155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569001156 nucleotide binding region [chemical binding]; other site 694569001157 ATP-binding site [chemical binding]; other site 694569001158 Helicase associated domain (HA2); Region: HA2; pfam04408 694569001159 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 694569001160 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 694569001161 Protein of unknown function (DUF423); Region: DUF423; cl01008 694569001162 Predicted membrane protein [Function unknown]; Region: COG2707 694569001163 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 694569001164 putative GSH binding site [chemical binding]; other site 694569001165 catalytic residues [active] 694569001166 outer membrane protein A; Reviewed; Region: PRK10808 694569001167 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 694569001168 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694569001169 ligand binding site [chemical binding]; other site 694569001170 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 694569001171 FAD binding domain; Region: FAD_binding_4; pfam01565 694569001172 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 694569001173 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 694569001174 CoenzymeA binding site [chemical binding]; other site 694569001175 subunit interaction site [polypeptide binding]; other site 694569001176 PHB binding site; other site 694569001177 ferrochelatase; Reviewed; Region: hemH; PRK00035 694569001178 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 694569001179 C-terminal domain interface [polypeptide binding]; other site 694569001180 active site 694569001181 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 694569001182 active site 694569001183 N-terminal domain interface [polypeptide binding]; other site 694569001184 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 694569001185 dimer interface [polypeptide binding]; other site 694569001186 catalytic triad [active] 694569001187 peroxidatic and resolving cysteines [active] 694569001188 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 694569001189 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 694569001190 active site 694569001191 dimer interface [polypeptide binding]; other site 694569001192 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 694569001193 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 694569001194 active site 694569001195 trimer interface [polypeptide binding]; other site 694569001196 allosteric site; other site 694569001197 active site lid [active] 694569001198 hexamer (dimer of trimers) interface [polypeptide binding]; other site 694569001199 N-acetylneuraminate lyase; Provisional; Region: PRK04147 694569001200 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 694569001201 inhibitor site; inhibition site 694569001202 active site 694569001203 dimer interface [polypeptide binding]; other site 694569001204 catalytic residue [active] 694569001205 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 694569001206 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 694569001207 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 694569001208 putative active site [active] 694569001209 N-acetylmannosamine kinase; Provisional; Region: PRK05082 694569001210 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 694569001211 nucleotide binding site [chemical binding]; other site 694569001212 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 694569001213 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 694569001214 putative active site cavity [active] 694569001215 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 694569001216 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 694569001217 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 694569001218 DctM-like transporters; Region: DctM; pfam06808 694569001219 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 694569001220 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 694569001221 Kelch motif; Region: Kelch_1; pfam01344 694569001222 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 694569001223 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 694569001224 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 694569001225 active site turn [active] 694569001226 phosphorylation site [posttranslational modification] 694569001227 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569001228 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569001229 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569001230 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569001231 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 694569001232 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 694569001233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694569001234 binding surface 694569001235 TPR motif; other site 694569001236 TPR repeat; Region: TPR_11; pfam13414 694569001237 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 694569001238 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 694569001239 MarR family; Region: MarR_2; cl17246 694569001240 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 694569001241 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 694569001242 nucleotide binding site [chemical binding]; other site 694569001243 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 694569001244 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 694569001245 tRNA; other site 694569001246 putative tRNA binding site [nucleotide binding]; other site 694569001247 putative NADP binding site [chemical binding]; other site 694569001248 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 694569001249 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 694569001250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569001251 S-adenosylmethionine binding site [chemical binding]; other site 694569001252 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 694569001253 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 694569001254 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 694569001255 active site turn [active] 694569001256 phosphorylation site [posttranslational modification] 694569001257 Uncharacterized conserved protein [Function unknown]; Region: COG3422 694569001258 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 694569001259 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 694569001260 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 694569001261 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 694569001262 uncharacterized domain; Region: TIGR00702 694569001263 YcaO-like family; Region: YcaO; pfam02624 694569001264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 694569001265 Protein of unknown function (DUF1043); Region: DUF1043; pfam06295 694569001266 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 694569001267 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 694569001268 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 694569001269 protein binding site [polypeptide binding]; other site 694569001270 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 694569001271 outer membrane protein A; Reviewed; Region: PRK10808 694569001272 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 694569001273 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694569001274 ligand binding site [chemical binding]; other site 694569001275 excinuclease ABC subunit B; Provisional; Region: PRK05298 694569001276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569001277 ATP binding site [chemical binding]; other site 694569001278 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569001279 nucleotide binding region [chemical binding]; other site 694569001280 ATP-binding site [chemical binding]; other site 694569001281 Ultra-violet resistance protein B; Region: UvrB; pfam12344 694569001282 UvrB/uvrC motif; Region: UVR; pfam02151 694569001283 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 694569001284 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 694569001285 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 694569001286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569001287 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569001288 ABC transporter; Region: ABC_tran_2; pfam12848 694569001289 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569001290 YadA-like C-terminal region; Region: YadA; pfam03895 694569001291 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 694569001292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569001293 ATP binding site [chemical binding]; other site 694569001294 Mg2+ binding site [ion binding]; other site 694569001295 G-X-G motif; other site 694569001296 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 694569001297 anchoring element; other site 694569001298 dimer interface [polypeptide binding]; other site 694569001299 ATP binding site [chemical binding]; other site 694569001300 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 694569001301 active site 694569001302 putative metal-binding site [ion binding]; other site 694569001303 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 694569001304 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 694569001305 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 694569001306 CAP-like domain; other site 694569001307 active site 694569001308 primary dimer interface [polypeptide binding]; other site 694569001309 glutathionine S-transferase; Provisional; Region: PRK10542 694569001310 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 694569001311 C-terminal domain interface [polypeptide binding]; other site 694569001312 GSH binding site (G-site) [chemical binding]; other site 694569001313 dimer interface [polypeptide binding]; other site 694569001314 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 694569001315 dimer interface [polypeptide binding]; other site 694569001316 substrate binding pocket (H-site) [chemical binding]; other site 694569001317 N-terminal domain interface [polypeptide binding]; other site 694569001318 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 694569001319 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 694569001320 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 694569001321 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694569001322 ligand binding site [chemical binding]; other site 694569001323 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 694569001324 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 694569001325 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 694569001326 tandem repeat interface [polypeptide binding]; other site 694569001327 oligomer interface [polypeptide binding]; other site 694569001328 active site residues [active] 694569001329 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 694569001330 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 694569001331 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 694569001332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694569001333 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 694569001334 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 694569001335 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 694569001336 putative SAM binding site [chemical binding]; other site 694569001337 putative homodimer interface [polypeptide binding]; other site 694569001338 LppC putative lipoprotein; Region: LppC; pfam04348 694569001339 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 694569001340 putative ligand binding site [chemical binding]; other site 694569001341 hypothetical protein; Reviewed; Region: PRK12497 694569001342 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 694569001343 dimer interface [polypeptide binding]; other site 694569001344 active site 694569001345 outer membrane lipoprotein; Provisional; Region: PRK11023 694569001346 BON domain; Region: BON; pfam04972 694569001347 BON domain; Region: BON; cl02771 694569001348 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 694569001349 active site clefts [active] 694569001350 zinc binding site [ion binding]; other site 694569001351 dimer interface [polypeptide binding]; other site 694569001352 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 694569001353 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 694569001354 SelR domain; Region: SelR; pfam01641 694569001355 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 694569001356 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 694569001357 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 694569001358 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694569001359 catalytic residues [active] 694569001360 Integrase core domain; Region: rve; pfam00665 694569001361 Integrase core domain; Region: rve_2; pfam13333 694569001362 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 694569001363 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 694569001364 RelB antitoxin; Region: RelB; cl01171 694569001365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 694569001366 GMP synthase; Reviewed; Region: guaA; PRK00074 694569001367 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 694569001368 AMP/PPi binding site [chemical binding]; other site 694569001369 candidate oxyanion hole; other site 694569001370 catalytic triad [active] 694569001371 potential glutamine specificity residues [chemical binding]; other site 694569001372 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 694569001373 ATP Binding subdomain [chemical binding]; other site 694569001374 Ligand Binding sites [chemical binding]; other site 694569001375 Dimerization subdomain; other site 694569001376 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 694569001377 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 694569001378 pyridoxamine kinase; Validated; Region: PRK05756 694569001379 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 694569001380 dimer interface [polypeptide binding]; other site 694569001381 pyridoxal binding site [chemical binding]; other site 694569001382 ATP binding site [chemical binding]; other site 694569001383 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 694569001384 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 694569001385 Ligand Binding Site [chemical binding]; other site 694569001386 TilS substrate binding domain; Region: TilS; pfam09179 694569001387 TilS substrate C-terminal domain; Region: TilS_C; smart00977 694569001388 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 694569001389 Protein of unknown function (DUF805); Region: DUF805; pfam05656 694569001390 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 694569001391 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 694569001392 NAD binding site [chemical binding]; other site 694569001393 homodimer interface [polypeptide binding]; other site 694569001394 active site 694569001395 substrate binding site [chemical binding]; other site 694569001396 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 694569001397 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 694569001398 muropeptide transporter; Reviewed; Region: ampG; PRK11902 694569001399 AmpG-like permease; Region: 2A0125; TIGR00901 694569001400 adenylate kinase; Reviewed; Region: adk; PRK00279 694569001401 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 694569001402 AMP-binding site [chemical binding]; other site 694569001403 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 694569001404 Transposase; Region: HTH_Tnp_1; cl17663 694569001405 DNA repair protein RadA; Provisional; Region: PRK11823 694569001406 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 694569001407 Walker A motif; other site 694569001408 ATP binding site [chemical binding]; other site 694569001409 Walker B motif; other site 694569001410 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 694569001411 Uncharacterized conserved protein [Function unknown]; Region: COG3025 694569001412 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 694569001413 putative active site [active] 694569001414 putative metal binding residues [ion binding]; other site 694569001415 signature motif; other site 694569001416 putative triphosphate binding site [ion binding]; other site 694569001417 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 694569001418 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 694569001419 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 694569001420 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 694569001421 Bacterial SH3 domain homologues; Region: SH3b; smart00287 694569001422 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 694569001423 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 694569001424 active site 694569001425 NTP binding site [chemical binding]; other site 694569001426 metal binding triad [ion binding]; metal-binding site 694569001427 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 694569001428 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694569001429 Zn2+ binding site [ion binding]; other site 694569001430 Mg2+ binding site [ion binding]; other site 694569001431 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 694569001432 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 694569001433 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 694569001434 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 694569001435 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694569001436 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 694569001437 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 694569001438 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569001439 active site 694569001440 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 694569001441 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 694569001442 phosphate binding site [ion binding]; other site 694569001443 L-lactate permease; Region: Lactate_perm; cl00701 694569001444 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 694569001445 hypothetical protein; Provisional; Region: PRK05423 694569001446 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 694569001447 homodimer interface [polypeptide binding]; other site 694569001448 substrate-cofactor binding pocket; other site 694569001449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569001450 catalytic residue [active] 694569001451 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 694569001452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694569001453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569001454 homodimer interface [polypeptide binding]; other site 694569001455 catalytic residue [active] 694569001456 Heavy-metal-associated domain; Region: HMA; pfam00403 694569001457 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 694569001458 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 694569001459 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 694569001460 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 694569001461 hinge; other site 694569001462 active site 694569001463 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 694569001464 RNA/DNA hybrid binding site [nucleotide binding]; other site 694569001465 active site 694569001466 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 694569001467 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 694569001468 active site 694569001469 catalytic site [active] 694569001470 substrate binding site [chemical binding]; other site 694569001471 primosomal protein DnaI; Provisional; Region: PRK02854 694569001472 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 694569001473 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 694569001474 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 694569001475 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 694569001476 putative protease; Provisional; Region: PRK15452 694569001477 Peptidase family U32; Region: Peptidase_U32; pfam01136 694569001478 WYL domain; Region: WYL; pfam13280 694569001479 Fic family protein [Function unknown]; Region: COG3177 694569001480 Fic/DOC family; Region: Fic; pfam02661 694569001481 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 694569001482 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 694569001483 nucleotide binding site [chemical binding]; other site 694569001484 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 694569001485 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 694569001486 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 694569001487 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694569001488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569001489 homodimer interface [polypeptide binding]; other site 694569001490 catalytic residue [active] 694569001491 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 694569001492 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 694569001493 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 694569001494 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 694569001495 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 694569001496 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 694569001497 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 694569001498 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 694569001499 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 694569001500 Protein export membrane protein; Region: SecD_SecF; pfam02355 694569001501 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 694569001502 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694569001503 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694569001504 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 694569001505 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 694569001506 putative catalytic cysteine [active] 694569001507 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 694569001508 putative active site [active] 694569001509 metal binding site [ion binding]; metal-binding site 694569001510 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569001511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569001512 TM-ABC transporter signature motif; other site 694569001513 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 694569001514 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 694569001515 Walker A/P-loop; other site 694569001516 ATP binding site [chemical binding]; other site 694569001517 Q-loop/lid; other site 694569001518 ABC transporter signature motif; other site 694569001519 Walker B; other site 694569001520 D-loop; other site 694569001521 H-loop/switch region; other site 694569001522 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 694569001523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 694569001524 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 694569001525 putative ligand binding site [chemical binding]; other site 694569001526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 694569001527 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 694569001528 putative ligand binding site [chemical binding]; other site 694569001529 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 694569001530 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 694569001531 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 694569001532 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 694569001533 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 694569001534 tetrameric interface [polypeptide binding]; other site 694569001535 NAD binding site [chemical binding]; other site 694569001536 catalytic residues [active] 694569001537 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 694569001538 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cl12127 694569001539 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 694569001540 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 694569001541 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 694569001542 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 694569001543 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 694569001544 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 694569001545 active site 694569001546 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 694569001547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569001548 FeS/SAM binding site; other site 694569001549 Uncharacterized conserved protein [Function unknown]; Region: COG0327 694569001550 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 694569001551 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 694569001552 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 694569001553 NAD binding site [chemical binding]; other site 694569001554 homotetramer interface [polypeptide binding]; other site 694569001555 homodimer interface [polypeptide binding]; other site 694569001556 substrate binding site [chemical binding]; other site 694569001557 active site 694569001558 exoribonuclease II; Provisional; Region: PRK05054 694569001559 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 694569001560 RNB domain; Region: RNB; pfam00773 694569001561 S1 RNA binding domain; Region: S1; pfam00575 694569001562 RNA binding site [nucleotide binding]; other site 694569001563 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 694569001564 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 694569001565 dimerization interface [polypeptide binding]; other site 694569001566 DPS ferroxidase diiron center [ion binding]; other site 694569001567 ion pore; other site 694569001568 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 694569001569 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694569001570 HlyD family secretion protein; Region: HlyD_3; pfam13437 694569001571 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 694569001572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569001573 putative substrate translocation pore; other site 694569001574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569001575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569001576 non-specific DNA binding site [nucleotide binding]; other site 694569001577 salt bridge; other site 694569001578 sequence-specific DNA binding site [nucleotide binding]; other site 694569001579 HipA N-terminal domain; Region: Couple_hipA; cl11853 694569001580 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 694569001581 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 694569001582 HIGH motif; other site 694569001583 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 694569001584 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 694569001585 active site 694569001586 KMSKS motif; other site 694569001587 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 694569001588 tRNA binding surface [nucleotide binding]; other site 694569001589 anticodon binding site; other site 694569001590 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 694569001591 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 694569001592 DNA polymerase III subunit chi; Validated; Region: PRK05728 694569001593 fumarate hydratase; Reviewed; Region: fumC; PRK00485 694569001594 Class II fumarases; Region: Fumarase_classII; cd01362 694569001595 active site 694569001596 tetramer interface [polypeptide binding]; other site 694569001597 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 694569001598 RimK-like ATP-grasp domain; Region: RimK; pfam08443 694569001599 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 694569001600 dimer interface [polypeptide binding]; other site 694569001601 FMN binding site [chemical binding]; other site 694569001602 NADPH bind site [chemical binding]; other site 694569001603 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 694569001604 GSH binding site [chemical binding]; other site 694569001605 catalytic residues [active] 694569001606 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 694569001607 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 694569001608 aromatic amino acid transport protein; Region: araaP; TIGR00837 694569001609 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569001610 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 694569001611 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 694569001612 intersubunit interface [polypeptide binding]; other site 694569001613 active site 694569001614 Zn2+ binding site [ion binding]; other site 694569001615 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 694569001616 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 694569001617 AP (apurinic/apyrimidinic) site pocket; other site 694569001618 DNA interaction; other site 694569001619 Metal-binding active site; metal-binding site 694569001620 transcriptional repressor UlaR; Provisional; Region: PRK13509 694569001621 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 694569001622 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 694569001623 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 694569001624 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 694569001625 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 694569001626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 694569001627 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 694569001628 active site 694569001629 P-loop; other site 694569001630 phosphorylation site [posttranslational modification] 694569001631 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 694569001632 active site 694569001633 phosphorylation site [posttranslational modification] 694569001634 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 694569001635 active site 694569001636 dimer interface [polypeptide binding]; other site 694569001637 magnesium binding site [ion binding]; other site 694569001638 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 694569001639 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 694569001640 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 694569001641 putative active site [active] 694569001642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694569001643 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 694569001644 substrate binding site [chemical binding]; other site 694569001645 ATP binding site [chemical binding]; other site 694569001646 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 694569001647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 694569001648 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 694569001649 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 694569001650 PYR/PP interface [polypeptide binding]; other site 694569001651 dimer interface [polypeptide binding]; other site 694569001652 TPP binding site [chemical binding]; other site 694569001653 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 694569001654 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 694569001655 TPP-binding site; other site 694569001656 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 694569001657 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 694569001658 Metal-binding active site; metal-binding site 694569001659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 694569001660 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 694569001661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 694569001662 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 694569001663 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 694569001664 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 694569001665 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 694569001666 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 694569001667 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 694569001668 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 694569001669 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 694569001670 active site 694569001671 P-loop; other site 694569001672 phosphorylation site [posttranslational modification] 694569001673 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 694569001674 active site 694569001675 phosphorylation site [posttranslational modification] 694569001676 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 694569001677 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694569001678 HlyD family secretion protein; Region: HlyD_3; pfam13437 694569001679 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 694569001680 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 694569001681 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694569001682 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 694569001683 Walker A/P-loop; other site 694569001684 ATP binding site [chemical binding]; other site 694569001685 Q-loop/lid; other site 694569001686 ABC transporter signature motif; other site 694569001687 Walker B; other site 694569001688 D-loop; other site 694569001689 H-loop/switch region; other site 694569001690 RTX N-terminal domain; Region: RTX; pfam02382 694569001691 RTX C-terminal domain; Region: RTX_C; pfam08339 694569001692 RTX toxin acyltransferase family; Region: HlyC; pfam02794 694569001693 Actinobacillus actinomycetemcomitans leukotoxin activator LktC; Region: LktC; pfam06261 694569001694 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 694569001695 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 694569001696 dimer interface [polypeptide binding]; other site 694569001697 active site 694569001698 glycine-pyridoxal phosphate binding site [chemical binding]; other site 694569001699 folate binding site [chemical binding]; other site 694569001700 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 694569001701 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 694569001702 active site turn [active] 694569001703 phosphorylation site [posttranslational modification] 694569001704 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 694569001705 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 694569001706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569001707 S-adenosylmethionine binding site [chemical binding]; other site 694569001708 DNA polymerase III subunit psi; Validated; Region: PRK06856 694569001709 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 694569001710 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 694569001711 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 694569001712 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 694569001713 Protein of unknown function (DUF2572); Region: DUF2572; pfam10833 694569001714 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 694569001715 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 694569001716 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 694569001717 ligand binding site [chemical binding]; other site 694569001718 translocation protein TolB; Provisional; Region: tolB; PRK01742 694569001719 TolB amino-terminal domain; Region: TolB_N; pfam04052 694569001720 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694569001721 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694569001722 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 694569001723 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 694569001724 TolA C-terminal; Region: TolA; pfam06519 694569001725 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 694569001726 colicin uptake protein TolR; Provisional; Region: PRK11024 694569001727 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 694569001728 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694569001729 active site 694569001730 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 694569001731 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 694569001732 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 694569001733 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 694569001734 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 694569001735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569001736 Walker A motif; other site 694569001737 ATP binding site [chemical binding]; other site 694569001738 Walker B motif; other site 694569001739 arginine finger; other site 694569001740 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 694569001741 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 694569001742 RuvA N terminal domain; Region: RuvA_N; pfam01330 694569001743 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 694569001744 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 694569001745 active site 694569001746 putative DNA-binding cleft [nucleotide binding]; other site 694569001747 dimer interface [polypeptide binding]; other site 694569001748 hypothetical protein; Validated; Region: PRK00110 694569001749 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 694569001750 nudix motif; other site 694569001751 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 694569001752 HTH-like domain; Region: HTH_21; pfam13276 694569001753 Integrase core domain; Region: rve; pfam00665 694569001754 Integrase core domain; Region: rve_2; pfam13333 694569001755 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 694569001756 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 694569001757 dimer interface [polypeptide binding]; other site 694569001758 anticodon binding site; other site 694569001759 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 694569001760 homodimer interface [polypeptide binding]; other site 694569001761 motif 1; other site 694569001762 active site 694569001763 motif 2; other site 694569001764 GAD domain; Region: GAD; pfam02938 694569001765 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 694569001766 active site 694569001767 motif 3; other site 694569001768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 694569001769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569001770 S-adenosylmethionine binding site [chemical binding]; other site 694569001771 Predicted membrane protein [Function unknown]; Region: COG4984 694569001772 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 694569001773 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 694569001774 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 694569001775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569001776 putative substrate translocation pore; other site 694569001777 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 694569001778 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694569001779 N-terminal plug; other site 694569001780 ligand-binding site [chemical binding]; other site 694569001781 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 694569001782 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 694569001783 dimer interface [polypeptide binding]; other site 694569001784 active site 694569001785 metal binding site [ion binding]; metal-binding site 694569001786 glutathione binding site [chemical binding]; other site 694569001787 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 694569001788 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 694569001789 dimer interface [polypeptide binding]; other site 694569001790 catalytic site [active] 694569001791 putative active site [active] 694569001792 putative substrate binding site [chemical binding]; other site 694569001793 Predicted permease [General function prediction only]; Region: COG2056 694569001794 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 694569001795 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 694569001796 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 694569001797 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694569001798 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569001799 FeS/SAM binding site; other site 694569001800 TRAM domain; Region: TRAM; pfam01938 694569001801 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 694569001802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 694569001803 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 694569001804 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 694569001805 substrate binding pocket [chemical binding]; other site 694569001806 chain length determination region; other site 694569001807 substrate-Mg2+ binding site; other site 694569001808 catalytic residues [active] 694569001809 aspartate-rich region 1; other site 694569001810 active site lid residues [active] 694569001811 aspartate-rich region 2; other site 694569001812 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 694569001813 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 694569001814 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 694569001815 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694569001816 EamA-like transporter family; Region: EamA; pfam00892 694569001817 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694569001818 EamA-like transporter family; Region: EamA; pfam00892 694569001819 EamA-like transporter family; Region: EamA; pfam00892 694569001820 GTPase CgtA; Reviewed; Region: obgE; PRK12298 694569001821 GTP1/OBG; Region: GTP1_OBG; pfam01018 694569001822 Obg GTPase; Region: Obg; cd01898 694569001823 G1 box; other site 694569001824 GTP/Mg2+ binding site [chemical binding]; other site 694569001825 Switch I region; other site 694569001826 G2 box; other site 694569001827 G3 box; other site 694569001828 Switch II region; other site 694569001829 G4 box; other site 694569001830 G5 box; other site 694569001831 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 694569001832 SmpB-tmRNA interface; other site 694569001833 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 694569001834 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 694569001835 peptide binding site [polypeptide binding]; other site 694569001836 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 694569001837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569001838 dimer interface [polypeptide binding]; other site 694569001839 conserved gate region; other site 694569001840 putative PBP binding loops; other site 694569001841 ABC-ATPase subunit interface; other site 694569001842 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 694569001843 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 694569001844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569001845 dimer interface [polypeptide binding]; other site 694569001846 conserved gate region; other site 694569001847 ABC-ATPase subunit interface; other site 694569001848 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 694569001849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 694569001850 Walker A/P-loop; other site 694569001851 ATP binding site [chemical binding]; other site 694569001852 Q-loop/lid; other site 694569001853 ABC transporter signature motif; other site 694569001854 Walker B; other site 694569001855 D-loop; other site 694569001856 H-loop/switch region; other site 694569001857 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 694569001858 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 694569001859 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 694569001860 Walker A/P-loop; other site 694569001861 ATP binding site [chemical binding]; other site 694569001862 Q-loop/lid; other site 694569001863 ABC transporter signature motif; other site 694569001864 Walker B; other site 694569001865 D-loop; other site 694569001866 H-loop/switch region; other site 694569001867 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 694569001868 two-component response regulator; Provisional; Region: PRK11173 694569001869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694569001870 active site 694569001871 phosphorylation site [posttranslational modification] 694569001872 intermolecular recognition site; other site 694569001873 dimerization interface [polypeptide binding]; other site 694569001874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694569001875 DNA binding site [nucleotide binding] 694569001876 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 694569001877 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 694569001878 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 694569001879 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 694569001880 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 694569001881 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 694569001882 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 694569001883 DsbD alpha interface [polypeptide binding]; other site 694569001884 catalytic residues [active] 694569001885 Predicted membrane protein [Function unknown]; Region: COG2259 694569001886 ribonuclease E; Reviewed; Region: rne; PRK10811 694569001887 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 694569001888 homodimer interface [polypeptide binding]; other site 694569001889 oligonucleotide binding site [chemical binding]; other site 694569001890 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 694569001891 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 694569001892 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569001893 RNA binding surface [nucleotide binding]; other site 694569001894 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694569001895 active site 694569001896 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 694569001897 catalytic residues [active] 694569001898 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 694569001899 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 694569001900 putative ligand binding site [chemical binding]; other site 694569001901 putative NAD binding site [chemical binding]; other site 694569001902 catalytic site [active] 694569001903 cystathionine gamma-synthase; Reviewed; Region: PRK08247 694569001904 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 694569001905 homodimer interface [polypeptide binding]; other site 694569001906 substrate-cofactor binding pocket; other site 694569001907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569001908 catalytic residue [active] 694569001909 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 694569001910 Integrase core domain; Region: rve_3; cl15866 694569001911 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569001912 Integrase core domain; Region: rve_3; pfam13683 694569001913 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 694569001914 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 694569001915 active site 694569001916 dimerization interface [polypeptide binding]; other site 694569001917 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 694569001918 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 694569001919 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 694569001920 Rrf2 family protein; Region: rrf2_super; TIGR00738 694569001921 cysteine desulfurase; Provisional; Region: PRK14012 694569001922 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 694569001923 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694569001924 catalytic residue [active] 694569001925 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 694569001926 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 694569001927 active site 694569001928 trimerization site [polypeptide binding]; other site 694569001929 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 694569001930 co-chaperone HscB; Provisional; Region: hscB; PRK01773 694569001931 DnaJ domain; Region: DnaJ; pfam00226 694569001932 HSP70 interaction site [polypeptide binding]; other site 694569001933 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 694569001934 chaperone protein HscA; Provisional; Region: hscA; PRK05183 694569001935 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 694569001936 nucleotide binding site [chemical binding]; other site 694569001937 putative NEF/HSP70 interaction site [polypeptide binding]; other site 694569001938 SBD interface [polypeptide binding]; other site 694569001939 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 694569001940 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 694569001941 catalytic loop [active] 694569001942 iron binding site [ion binding]; other site 694569001943 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 694569001944 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 694569001945 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 694569001946 active site 694569001947 HIGH motif; other site 694569001948 KMSKS motif; other site 694569001949 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 694569001950 tRNA binding surface [nucleotide binding]; other site 694569001951 anticodon binding site; other site 694569001952 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 694569001953 dimer interface [polypeptide binding]; other site 694569001954 putative tRNA-binding site [nucleotide binding]; other site 694569001955 antiporter inner membrane protein; Provisional; Region: PRK11670 694569001956 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 694569001957 Walker A motif; other site 694569001958 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569001959 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569001960 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569001961 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569001962 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 694569001963 nucleoside/Zn binding site; other site 694569001964 dimer interface [polypeptide binding]; other site 694569001965 catalytic motif [active] 694569001966 thymidylate synthase; Reviewed; Region: thyA; PRK01827 694569001967 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 694569001968 dimerization interface [polypeptide binding]; other site 694569001969 active site 694569001970 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 694569001971 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 694569001972 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 694569001973 putative active site [active] 694569001974 Ap4A binding site [chemical binding]; other site 694569001975 nudix motif; other site 694569001976 putative metal binding site [ion binding]; other site 694569001977 D-ribose pyranase; Provisional; Region: PRK11797 694569001978 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 694569001979 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 694569001980 Walker A/P-loop; other site 694569001981 ATP binding site [chemical binding]; other site 694569001982 Q-loop/lid; other site 694569001983 ABC transporter signature motif; other site 694569001984 Walker B; other site 694569001985 D-loop; other site 694569001986 H-loop/switch region; other site 694569001987 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 694569001988 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569001989 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569001990 TM-ABC transporter signature motif; other site 694569001991 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 694569001992 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 694569001993 ligand binding site [chemical binding]; other site 694569001994 dimerization interface [polypeptide binding]; other site 694569001995 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694569001996 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 694569001997 substrate binding site [chemical binding]; other site 694569001998 dimer interface [polypeptide binding]; other site 694569001999 ATP binding site [chemical binding]; other site 694569002000 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 694569002001 DNA-binding site [nucleotide binding]; DNA binding site 694569002002 RNA-binding motif; other site 694569002003 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 694569002004 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 694569002005 argininosuccinate lyase; Provisional; Region: PRK04833 694569002006 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 694569002007 active sites [active] 694569002008 tetramer interface [polypeptide binding]; other site 694569002009 glutamate dehydrogenase; Provisional; Region: PRK09414 694569002010 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 694569002011 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 694569002012 NAD(P) binding site [chemical binding]; other site 694569002013 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 694569002014 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 694569002015 tetramer interface [polypeptide binding]; other site 694569002016 heme binding pocket [chemical binding]; other site 694569002017 NADPH binding site [chemical binding]; other site 694569002018 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569002019 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 694569002020 nucleophilic elbow; other site 694569002021 catalytic triad; other site 694569002022 FOG: WD40 repeat [General function prediction only]; Region: COG2319 694569002023 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 694569002024 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 694569002025 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 694569002026 putative active site [active] 694569002027 putative PHP Thumb interface [polypeptide binding]; other site 694569002028 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 694569002029 generic binding surface I; other site 694569002030 generic binding surface II; other site 694569002031 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 694569002032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694569002033 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 694569002034 acyl-activating enzyme (AAE) consensus motif; other site 694569002035 putative AMP binding site [chemical binding]; other site 694569002036 putative active site [active] 694569002037 putative CoA binding site [chemical binding]; other site 694569002038 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 694569002039 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 694569002040 trimer interface [polypeptide binding]; other site 694569002041 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 694569002042 trimer interface [polypeptide binding]; other site 694569002043 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 694569002044 YadA-like C-terminal region; Region: YadA; pfam03895 694569002045 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 694569002046 ATP cone domain; Region: ATP-cone; pfam03477 694569002047 Class III ribonucleotide reductase; Region: RNR_III; cd01675 694569002048 effector binding site; other site 694569002049 active site 694569002050 Zn binding site [ion binding]; other site 694569002051 glycine loop; other site 694569002052 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 694569002053 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569002054 FeS/SAM binding site; other site 694569002055 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 694569002056 active site 694569002057 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 694569002058 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 694569002059 substrate binding site [chemical binding]; other site 694569002060 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 694569002061 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 694569002062 active site 694569002063 HIGH motif; other site 694569002064 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 694569002065 KMSKS motif; other site 694569002066 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 694569002067 tRNA binding surface [nucleotide binding]; other site 694569002068 anticodon binding site; other site 694569002069 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569002070 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 694569002071 Cation transport protein; Region: TrkH; cl17365 694569002072 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 694569002073 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 694569002074 hypothetical protein; Provisional; Region: PRK11568 694569002075 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 694569002076 CPxP motif; other site 694569002077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 694569002078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569002079 non-specific DNA binding site [nucleotide binding]; other site 694569002080 salt bridge; other site 694569002081 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 694569002082 sequence-specific DNA binding site [nucleotide binding]; other site 694569002083 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 694569002084 active site 694569002085 (T/H)XGH motif; other site 694569002086 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 694569002087 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694569002088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 694569002089 active site 694569002090 metal binding site [ion binding]; metal-binding site 694569002091 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 694569002092 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 694569002093 aromatic amino acid transport protein; Region: araaP; TIGR00837 694569002094 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 694569002095 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 694569002096 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 694569002097 alphaNTD homodimer interface [polypeptide binding]; other site 694569002098 alphaNTD - beta interaction site [polypeptide binding]; other site 694569002099 alphaNTD - beta' interaction site [polypeptide binding]; other site 694569002100 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 694569002101 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 694569002102 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 694569002103 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569002104 RNA binding surface [nucleotide binding]; other site 694569002105 30S ribosomal protein S11; Validated; Region: PRK05309 694569002106 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 694569002107 30S ribosomal protein S13; Region: bact_S13; TIGR03631 694569002108 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 694569002109 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 694569002110 SecY translocase; Region: SecY; pfam00344 694569002111 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 694569002112 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 694569002113 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 694569002114 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 694569002115 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 694569002116 23S rRNA interface [nucleotide binding]; other site 694569002117 L21e interface [polypeptide binding]; other site 694569002118 5S rRNA interface [nucleotide binding]; other site 694569002119 L27 interface [polypeptide binding]; other site 694569002120 L5 interface [polypeptide binding]; other site 694569002121 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 694569002122 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 694569002123 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 694569002124 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 694569002125 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 694569002126 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 694569002127 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 694569002128 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 694569002129 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 694569002130 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 694569002131 RNA binding site [nucleotide binding]; other site 694569002132 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 694569002133 Integrase core domain; Region: rve; pfam00665 694569002134 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 694569002135 dimer interface [polypeptide binding]; other site 694569002136 allosteric magnesium binding site [ion binding]; other site 694569002137 active site 694569002138 aspartate-rich active site metal binding site; other site 694569002139 Schiff base residues; other site 694569002140 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 694569002141 sec-independent translocase; Provisional; Region: PRK01770 694569002142 twin arginine translocase protein A; Provisional; Region: tatA; PRK01833 694569002143 FOG: WD40 repeat [General function prediction only]; Region: COG2319 694569002144 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 694569002145 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569002146 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 694569002147 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 694569002148 dimerization interface [polypeptide binding]; other site 694569002149 domain crossover interface; other site 694569002150 redox-dependent activation switch; other site 694569002151 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569002152 RNA binding surface [nucleotide binding]; other site 694569002153 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 694569002154 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 694569002155 motif II; other site 694569002156 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 694569002157 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 694569002158 ADP-ribose binding site [chemical binding]; other site 694569002159 dimer interface [polypeptide binding]; other site 694569002160 active site 694569002161 nudix motif; other site 694569002162 metal binding site [ion binding]; metal-binding site 694569002163 Cupin; Region: Cupin_6; pfam12852 694569002164 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 694569002165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694569002166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694569002167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694569002168 Predicted membrane protein [Function unknown]; Region: COG3059 694569002169 Predicted membrane protein [Function unknown]; Region: COG1297 694569002170 putative oligopeptide transporter, OPT family; Region: TIGR00733 694569002171 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 694569002172 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 694569002173 active site 694569002174 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 694569002175 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 694569002176 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 694569002177 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 694569002178 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 694569002179 putative active site [active] 694569002180 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 694569002181 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 694569002182 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 694569002183 Cl binding site [ion binding]; other site 694569002184 oligomer interface [polypeptide binding]; other site 694569002185 YGGT family; Region: YGGT; pfam02325 694569002186 Predicted integral membrane protein [Function unknown]; Region: COG0762 694569002187 hypothetical protein; Validated; Region: PRK05090 694569002188 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 694569002189 dimer interface [polypeptide binding]; other site 694569002190 FMN binding site [chemical binding]; other site 694569002191 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 694569002192 Sulfatase; Region: Sulfatase; pfam00884 694569002193 PAAR motif; Region: PAAR_motif; pfam05488 694569002194 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 694569002195 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 694569002196 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 694569002197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569002198 RNA binding surface [nucleotide binding]; other site 694569002199 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694569002200 active site 694569002201 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 694569002202 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 694569002203 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 694569002204 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 694569002205 hypothetical protein; Reviewed; Region: PRK01736 694569002206 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 694569002207 proline aminopeptidase P II; Provisional; Region: PRK10879 694569002208 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 694569002209 active site 694569002210 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 694569002211 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 694569002212 RimM N-terminal domain; Region: RimM; pfam01782 694569002213 PRC-barrel domain; Region: PRC; pfam05239 694569002214 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 694569002215 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 694569002216 rod shape-determining protein MreD; Region: MreD; cl01087 694569002217 rod shape-determining protein MreC; Region: mreC; TIGR00219 694569002218 rod shape-determining protein MreC; Region: MreC; pfam04085 694569002219 rod shape-determining protein MreB; Provisional; Region: PRK13927 694569002220 MreB and similar proteins; Region: MreB_like; cd10225 694569002221 nucleotide binding site [chemical binding]; other site 694569002222 Mg binding site [ion binding]; other site 694569002223 putative protofilament interaction site [polypeptide binding]; other site 694569002224 RodZ interaction site [polypeptide binding]; other site 694569002225 ribonuclease R; Region: RNase_R; TIGR02063 694569002226 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 694569002227 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 694569002228 RNB domain; Region: RNB; pfam00773 694569002229 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 694569002230 RNA binding site [nucleotide binding]; other site 694569002231 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 694569002232 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 694569002233 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 694569002234 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 694569002235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569002236 putative substrate translocation pore; other site 694569002237 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 694569002238 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 694569002239 active site 694569002240 catalytic site [active] 694569002241 metal binding site [ion binding]; metal-binding site 694569002242 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 694569002243 DNA protecting protein DprA; Region: dprA; TIGR00732 694569002244 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 694569002245 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 694569002246 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 694569002247 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 694569002248 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 694569002249 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 694569002250 LexA repressor; Validated; Region: PRK00215 694569002251 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 694569002252 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 694569002253 Catalytic site [active] 694569002254 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 694569002255 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 694569002256 putative acyl-acceptor binding pocket; other site 694569002257 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694569002258 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 694569002259 Walker A/P-loop; other site 694569002260 ATP binding site [chemical binding]; other site 694569002261 Q-loop/lid; other site 694569002262 ABC transporter signature motif; other site 694569002263 Walker B; other site 694569002264 D-loop; other site 694569002265 H-loop/switch region; other site 694569002266 Cupin; Region: Cupin_6; pfam12852 694569002267 Helix-turn-helix domain; Region: HTH_18; pfam12833 694569002268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694569002269 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 694569002270 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694569002271 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694569002272 putative active site [active] 694569002273 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 694569002274 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 694569002275 active site 694569002276 ATP binding site [chemical binding]; other site 694569002277 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 694569002278 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 694569002279 active site 694569002280 (T/H)XGH motif; other site 694569002281 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 694569002282 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 694569002283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694569002284 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694569002285 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 694569002286 putative metal binding site; other site 694569002287 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 694569002288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569002289 sequence-specific DNA binding site [nucleotide binding]; other site 694569002290 salt bridge; other site 694569002291 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 694569002292 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 694569002293 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 694569002294 domain interface [polypeptide binding]; other site 694569002295 putative active site [active] 694569002296 catalytic site [active] 694569002297 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 694569002298 domain interface [polypeptide binding]; other site 694569002299 putative active site [active] 694569002300 catalytic site [active] 694569002301 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 694569002302 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 694569002303 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 694569002304 ferredoxin; Validated; Region: PRK07118 694569002305 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 694569002306 B1 nucleotide binding pocket [chemical binding]; other site 694569002307 B2 nucleotide binding pocket [chemical binding]; other site 694569002308 CAS motifs; other site 694569002309 active site 694569002310 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 694569002311 Phosphoglycerate kinase; Region: PGK; pfam00162 694569002312 substrate binding site [chemical binding]; other site 694569002313 hinge regions; other site 694569002314 ADP binding site [chemical binding]; other site 694569002315 catalytic site [active] 694569002316 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 694569002317 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 694569002318 active site 694569002319 intersubunit interface [polypeptide binding]; other site 694569002320 zinc binding site [ion binding]; other site 694569002321 Na+ binding site [ion binding]; other site 694569002322 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 694569002323 O-Antigen ligase; Region: Wzy_C; pfam04932 694569002324 putative hydrolase; Provisional; Region: PRK10976 694569002325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569002326 active site 694569002327 motif I; other site 694569002328 motif II; other site 694569002329 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 694569002330 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 694569002331 dimer interface [polypeptide binding]; other site 694569002332 PYR/PP interface [polypeptide binding]; other site 694569002333 TPP binding site [chemical binding]; other site 694569002334 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 694569002335 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 694569002336 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 694569002337 TPP-binding site [chemical binding]; other site 694569002338 elongation factor Tu; Reviewed; Region: PRK00049 694569002339 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 694569002340 G1 box; other site 694569002341 GEF interaction site [polypeptide binding]; other site 694569002342 GTP/Mg2+ binding site [chemical binding]; other site 694569002343 Switch I region; other site 694569002344 G2 box; other site 694569002345 G3 box; other site 694569002346 Switch II region; other site 694569002347 G4 box; other site 694569002348 G5 box; other site 694569002349 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 694569002350 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 694569002351 Antibiotic Binding Site [chemical binding]; other site 694569002352 pantothenate kinase; Provisional; Region: PRK05439 694569002353 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 694569002354 ATP-binding site [chemical binding]; other site 694569002355 CoA-binding site [chemical binding]; other site 694569002356 Mg2+-binding site [ion binding]; other site 694569002357 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 694569002358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569002359 ATP binding site [chemical binding]; other site 694569002360 Mg2+ binding site [ion binding]; other site 694569002361 G-X-G motif; other site 694569002362 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 694569002363 anchoring element; other site 694569002364 dimer interface [polypeptide binding]; other site 694569002365 ATP binding site [chemical binding]; other site 694569002366 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 694569002367 active site 694569002368 putative metal-binding site [ion binding]; other site 694569002369 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 694569002370 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 694569002371 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569002372 ATP binding site [chemical binding]; other site 694569002373 putative Mg++ binding site [ion binding]; other site 694569002374 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569002375 nucleotide binding region [chemical binding]; other site 694569002376 ATP-binding site [chemical binding]; other site 694569002377 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 694569002378 HRDC domain; Region: HRDC; pfam00570 694569002379 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 694569002380 putative iron binding site [ion binding]; other site 694569002381 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 694569002382 diaminopimelate decarboxylase; Region: lysA; TIGR01048 694569002383 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 694569002384 active site 694569002385 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694569002386 substrate binding site [chemical binding]; other site 694569002387 catalytic residues [active] 694569002388 dimer interface [polypeptide binding]; other site 694569002389 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 694569002390 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 694569002391 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 694569002392 OstA-like protein; Region: OstA; pfam03968 694569002393 Organic solvent tolerance protein; Region: OstA_C; pfam04453 694569002394 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569002395 active site 694569002396 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 694569002397 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 694569002398 metal binding site [ion binding]; metal-binding site 694569002399 dimer interface [polypeptide binding]; other site 694569002400 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 694569002401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694569002402 NAD(P) binding site [chemical binding]; other site 694569002403 active site 694569002404 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 694569002405 Walker A motif; other site 694569002406 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 694569002407 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 694569002408 anti-sigma E factor; Provisional; Region: rseB; PRK09455 694569002409 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 694569002410 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 694569002411 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 694569002412 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 694569002413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694569002414 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694569002415 DNA binding residues [nucleotide binding] 694569002416 Uncharacterized conserved protein [Function unknown]; Region: COG2938 694569002417 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 694569002418 prolyl-tRNA synthetase; Provisional; Region: PRK09194 694569002419 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 694569002420 dimer interface [polypeptide binding]; other site 694569002421 motif 1; other site 694569002422 active site 694569002423 motif 2; other site 694569002424 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 694569002425 putative deacylase active site [active] 694569002426 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 694569002427 active site 694569002428 motif 3; other site 694569002429 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 694569002430 anticodon binding site; other site 694569002431 selenocysteine synthase; Provisional; Region: PRK04311 694569002432 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 694569002433 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 694569002434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694569002435 catalytic residue [active] 694569002436 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 694569002437 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 694569002438 G1 box; other site 694569002439 putative GEF interaction site [polypeptide binding]; other site 694569002440 GTP/Mg2+ binding site [chemical binding]; other site 694569002441 Switch I region; other site 694569002442 G2 box; other site 694569002443 G3 box; other site 694569002444 Switch II region; other site 694569002445 G4 box; other site 694569002446 G5 box; other site 694569002447 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 694569002448 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 694569002449 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 694569002450 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 694569002451 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 694569002452 Protein of unknown function (DUF972); Region: DUF972; pfam06156 694569002453 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 694569002454 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 694569002455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569002456 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 694569002457 Walker A motif; other site 694569002458 ATP binding site [chemical binding]; other site 694569002459 Walker B motif; other site 694569002460 arginine finger; other site 694569002461 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 694569002462 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 694569002463 MPT binding site; other site 694569002464 trimer interface [polypeptide binding]; other site 694569002465 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 694569002466 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 694569002467 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694569002468 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694569002469 putative acyl-acceptor binding pocket; other site 694569002470 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 694569002471 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 694569002472 transmembrane helices; other site 694569002473 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 694569002474 TrkA-C domain; Region: TrkA_C; pfam02080 694569002475 TrkA-C domain; Region: TrkA_C; pfam02080 694569002476 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 694569002477 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 694569002478 RNA/DNA hybrid binding site [nucleotide binding]; other site 694569002479 active site 694569002480 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 694569002481 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 694569002482 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 694569002483 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 694569002484 active site 694569002485 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 694569002486 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 694569002487 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 694569002488 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 694569002489 trimer interface [polypeptide binding]; other site 694569002490 active site 694569002491 UDP-GlcNAc binding site [chemical binding]; other site 694569002492 lipid binding site [chemical binding]; lipid-binding site 694569002493 periplasmic chaperone; Provisional; Region: PRK10780 694569002494 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 694569002495 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 694569002496 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694569002497 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694569002498 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694569002499 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694569002500 Surface antigen; Region: Bac_surface_Ag; pfam01103 694569002501 zinc metallopeptidase RseP; Provisional; Region: PRK10779 694569002502 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 694569002503 active site 694569002504 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 694569002505 protein binding site [polypeptide binding]; other site 694569002506 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 694569002507 protein binding site [polypeptide binding]; other site 694569002508 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 694569002509 putative substrate binding region [chemical binding]; other site 694569002510 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 694569002511 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 694569002512 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 694569002513 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 694569002514 catalytic residue [active] 694569002515 putative FPP diphosphate binding site; other site 694569002516 putative FPP binding hydrophobic cleft; other site 694569002517 dimer interface [polypeptide binding]; other site 694569002518 putative IPP diphosphate binding site; other site 694569002519 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 694569002520 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 694569002521 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 694569002522 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 694569002523 ribosome recycling factor; Reviewed; Region: frr; PRK00083 694569002524 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 694569002525 hinge region; other site 694569002526 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 694569002527 putative nucleotide binding site [chemical binding]; other site 694569002528 uridine monophosphate binding site [chemical binding]; other site 694569002529 homohexameric interface [polypeptide binding]; other site 694569002530 putative transporter; Validated; Region: PRK03818 694569002531 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 694569002532 TrkA-C domain; Region: TrkA_C; pfam02080 694569002533 TrkA-C domain; Region: TrkA_C; pfam02080 694569002534 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 694569002535 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 694569002536 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 694569002537 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 694569002538 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 694569002539 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694569002540 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 694569002541 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 694569002542 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 694569002543 intramembrane serine protease GlpG; Provisional; Region: PRK10907 694569002544 Rhomboid family; Region: Rhomboid; pfam01694 694569002545 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 694569002546 active site residue [active] 694569002547 hypothetical protein; Provisional; Region: PRK05208 694569002548 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 694569002549 RmuC family; Region: RmuC; pfam02646 694569002550 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 694569002551 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 694569002552 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 694569002553 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 694569002554 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 694569002555 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 694569002556 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 694569002557 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 694569002558 shikimate binding site; other site 694569002559 NAD(P) binding site [chemical binding]; other site 694569002560 Predicted permeases [General function prediction only]; Region: RarD; COG2962 694569002561 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 694569002562 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694569002563 ketol-acid reductoisomerase; Validated; Region: PRK05225 694569002564 30S ribosomal protein S12; Validated; Region: rpsL; PRK05163 694569002565 30S ribosomal protein S7; Validated; Region: PRK05302 694569002566 elongation factor G; Reviewed; Region: PRK00007 694569002567 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 694569002568 G1 box; other site 694569002569 putative GEF interaction site [polypeptide binding]; other site 694569002570 GTP/Mg2+ binding site [chemical binding]; other site 694569002571 Switch I region; other site 694569002572 G2 box; other site 694569002573 G3 box; other site 694569002574 Switch II region; other site 694569002575 G4 box; other site 694569002576 G5 box; other site 694569002577 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 694569002578 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 694569002579 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 694569002580 elongation factor Tu; Reviewed; Region: PRK00049 694569002581 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 694569002582 G1 box; other site 694569002583 GEF interaction site [polypeptide binding]; other site 694569002584 GTP/Mg2+ binding site [chemical binding]; other site 694569002585 Switch I region; other site 694569002586 G2 box; other site 694569002587 G3 box; other site 694569002588 Switch II region; other site 694569002589 G4 box; other site 694569002590 G5 box; other site 694569002591 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 694569002592 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 694569002593 Antibiotic Binding Site [chemical binding]; other site 694569002594 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 694569002595 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 694569002596 ligand binding site [chemical binding]; other site 694569002597 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 694569002598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569002599 Walker A/P-loop; other site 694569002600 ATP binding site [chemical binding]; other site 694569002601 Q-loop/lid; other site 694569002602 ABC transporter signature motif; other site 694569002603 Walker B; other site 694569002604 D-loop; other site 694569002605 H-loop/switch region; other site 694569002606 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 694569002607 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569002608 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569002609 TM-ABC transporter signature motif; other site 694569002610 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 694569002611 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 694569002612 putative N- and C-terminal domain interface [polypeptide binding]; other site 694569002613 putative active site [active] 694569002614 MgATP binding site [chemical binding]; other site 694569002615 catalytic site [active] 694569002616 metal binding site [ion binding]; metal-binding site 694569002617 putative xylulose binding site [chemical binding]; other site 694569002618 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 694569002619 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 694569002620 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 694569002621 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 694569002622 RNA binding site [nucleotide binding]; other site 694569002623 putative transposase OrfB; Reviewed; Region: PHA02517 694569002624 HTH-like domain; Region: HTH_21; pfam13276 694569002625 Integrase core domain; Region: rve; pfam00665 694569002626 Integrase core domain; Region: rve_2; pfam13333 694569002627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 694569002628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569002629 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 694569002630 putative dimerization interface [polypeptide binding]; other site 694569002631 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 694569002632 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 694569002633 transmembrane helices; other site 694569002634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694569002635 catalytic core [active] 694569002636 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 694569002637 RNA binding site [nucleotide binding]; other site 694569002638 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 694569002639 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 694569002640 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 694569002641 Putative zinc-finger; Region: zf-HC2; pfam13490 694569002642 RNA polymerase sigma factor; Provisional; Region: PRK12530 694569002643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694569002644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694569002645 DNA binding residues [nucleotide binding] 694569002646 hypothetical protein; Provisional; Region: PRK11212 694569002647 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 694569002648 HemY protein N-terminus; Region: HemY_N; pfam07219 694569002649 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 694569002650 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 694569002651 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 694569002652 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 694569002653 active site 694569002654 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 694569002655 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 694569002656 domain interfaces; other site 694569002657 active site 694569002658 adenylate cyclase; Provisional; Region: cyaA; PRK09450 694569002659 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 694569002660 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 694569002661 transcriptional regulator NarP; Provisional; Region: PRK10403 694569002662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694569002663 active site 694569002664 phosphorylation site [posttranslational modification] 694569002665 intermolecular recognition site; other site 694569002666 dimerization interface [polypeptide binding]; other site 694569002667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 694569002668 DNA binding residues [nucleotide binding] 694569002669 dimerization interface [polypeptide binding]; other site 694569002670 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 694569002671 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 694569002672 Surface antigen; Region: Bac_surface_Ag; pfam01103 694569002673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 694569002674 Family of unknown function (DUF490); Region: DUF490; pfam04357 694569002675 exopolyphosphatase; Provisional; Region: PRK10854 694569002676 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 694569002677 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 694569002678 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 694569002679 active site 694569002680 substrate-binding site [chemical binding]; other site 694569002681 metal-binding site [ion binding] 694569002682 ATP binding site [chemical binding]; other site 694569002683 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 694569002684 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 694569002685 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 694569002686 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 694569002687 putative NADH binding site [chemical binding]; other site 694569002688 putative active site [active] 694569002689 nudix motif; other site 694569002690 putative metal binding site [ion binding]; other site 694569002691 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 694569002692 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 694569002693 substrate binding site [chemical binding]; other site 694569002694 active site 694569002695 Protein of unknown function (DUF416); Region: DUF416; cl01166 694569002696 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 694569002697 IHF dimer interface [polypeptide binding]; other site 694569002698 IHF - DNA interface [nucleotide binding]; other site 694569002699 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 694569002700 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 694569002701 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 694569002702 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 694569002703 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 694569002704 glutaminase active site [active] 694569002705 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 694569002706 dimer interface [polypeptide binding]; other site 694569002707 active site 694569002708 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 694569002709 dimer interface [polypeptide binding]; other site 694569002710 active site 694569002711 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 694569002712 Transcriptional regulator [Transcription]; Region: LysR; COG0583 694569002713 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569002714 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 694569002715 putative effector binding pocket; other site 694569002716 putative dimerization interface [polypeptide binding]; other site 694569002717 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 694569002718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 694569002719 catalytic site [active] 694569002720 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 694569002721 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 694569002722 substrate binding pocket [chemical binding]; other site 694569002723 catalytic triad [active] 694569002724 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694569002725 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694569002726 active site 694569002727 catalytic tetrad [active] 694569002728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 694569002729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 694569002730 active site 694569002731 catalytic tetrad [active] 694569002732 Transcriptional regulator [Transcription]; Region: LysR; COG0583 694569002733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569002734 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 694569002735 putative effector binding pocket; other site 694569002736 putative dimerization interface [polypeptide binding]; other site 694569002737 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 694569002738 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 694569002739 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 694569002740 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 694569002741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 694569002742 MOSC domain; Region: MOSC; pfam03473 694569002743 hypothetical protein; Provisional; Region: PRK01752 694569002744 SEC-C motif; Region: SEC-C; pfam02810 694569002745 hypothetical protein; Reviewed; Region: PRK01637 694569002746 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 694569002747 putative active site [active] 694569002748 dimerization interface [polypeptide binding]; other site 694569002749 putative tRNAtyr binding site [nucleotide binding]; other site 694569002750 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 694569002751 two-component sensor protein; Provisional; Region: cpxA; PRK09470 694569002752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 694569002753 dimerization interface [polypeptide binding]; other site 694569002754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569002755 ATP binding site [chemical binding]; other site 694569002756 Mg2+ binding site [ion binding]; other site 694569002757 G-X-G motif; other site 694569002758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694569002759 active site 694569002760 phosphorylation site [posttranslational modification] 694569002761 intermolecular recognition site; other site 694569002762 dimerization interface [polypeptide binding]; other site 694569002763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 694569002764 DNA binding site [nucleotide binding] 694569002765 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 694569002766 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 694569002767 Nucleoid-associated protein [General function prediction only]; Region: COG3081 694569002768 nucleoid-associated protein NdpA; Validated; Region: PRK00378 694569002769 hypothetical protein; Provisional; Region: PRK13689 694569002770 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 694569002771 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 694569002772 Sulfatase; Region: Sulfatase; cl17466 694569002773 hypothetical protein; Validated; Region: PRK06886 694569002774 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 694569002775 active site 694569002776 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 694569002777 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 694569002778 homodimer interface [polypeptide binding]; other site 694569002779 metal binding site [ion binding]; metal-binding site 694569002780 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 694569002781 homodimer interface [polypeptide binding]; other site 694569002782 active site 694569002783 putative chemical substrate binding site [chemical binding]; other site 694569002784 metal binding site [ion binding]; metal-binding site 694569002785 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 694569002786 Ligand Binding Site [chemical binding]; other site 694569002787 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 694569002788 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 694569002789 motif 1; other site 694569002790 active site 694569002791 motif 2; other site 694569002792 motif 3; other site 694569002793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 694569002794 DHHA1 domain; Region: DHHA1; pfam02272 694569002795 carbon storage regulator; Provisional; Region: PRK01712 694569002796 phosphomannomutase CpsG; Provisional; Region: PRK15414 694569002797 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 694569002798 active site 694569002799 substrate binding site [chemical binding]; other site 694569002800 metal binding site [ion binding]; metal-binding site 694569002801 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 694569002802 active site 694569002803 tetramer interface; other site 694569002804 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 694569002805 dimerization interface [polypeptide binding]; other site 694569002806 DNA binding site [nucleotide binding] 694569002807 corepressor binding sites; other site 694569002808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 694569002809 RNA methyltransferase, RsmE family; Region: TIGR00046 694569002810 hypothetical protein; Validated; Region: PRK00228 694569002811 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 694569002812 enolase; Provisional; Region: eno; PRK00077 694569002813 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 694569002814 dimer interface [polypeptide binding]; other site 694569002815 metal binding site [ion binding]; metal-binding site 694569002816 substrate binding pocket [chemical binding]; other site 694569002817 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 694569002818 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 694569002819 Ligand Binding Site [chemical binding]; other site 694569002820 Protein of unknown function (DUF539); Region: DUF539; cl01129 694569002821 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 694569002822 ApbE family; Region: ApbE; pfam02424 694569002823 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 694569002824 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 694569002825 FAD binding pocket [chemical binding]; other site 694569002826 FAD binding motif [chemical binding]; other site 694569002827 phosphate binding motif [ion binding]; other site 694569002828 beta-alpha-beta structure motif; other site 694569002829 NAD binding pocket [chemical binding]; other site 694569002830 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 694569002831 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 694569002832 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 694569002833 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 694569002834 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 694569002835 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 694569002836 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694569002837 E3 interaction surface; other site 694569002838 lipoyl attachment site [posttranslational modification]; other site 694569002839 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 694569002840 BolA-like protein; Region: BolA; cl00386 694569002841 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056 694569002842 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 694569002843 murein transglycosylase C; Provisional; Region: mltC; PRK11671 694569002844 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 694569002845 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694569002846 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694569002847 catalytic residue [active] 694569002848 oxidative damage protection protein; Provisional; Region: PRK05408 694569002849 adenine DNA glycosylase; Provisional; Region: PRK10880 694569002850 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 694569002851 minor groove reading motif; other site 694569002852 helix-hairpin-helix signature motif; other site 694569002853 substrate binding pocket [chemical binding]; other site 694569002854 active site 694569002855 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 694569002856 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 694569002857 DNA binding and oxoG recognition site [nucleotide binding] 694569002858 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 694569002859 hypothetical protein; Provisional; Region: PRK11702 694569002860 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 694569002861 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 694569002862 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 694569002863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569002864 dimer interface [polypeptide binding]; other site 694569002865 conserved gate region; other site 694569002866 putative PBP binding loops; other site 694569002867 ABC-ATPase subunit interface; other site 694569002868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569002869 dimer interface [polypeptide binding]; other site 694569002870 conserved gate region; other site 694569002871 putative PBP binding loops; other site 694569002872 ABC-ATPase subunit interface; other site 694569002873 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 694569002874 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 694569002875 Walker A/P-loop; other site 694569002876 ATP binding site [chemical binding]; other site 694569002877 Q-loop/lid; other site 694569002878 ABC transporter signature motif; other site 694569002879 Walker B; other site 694569002880 D-loop; other site 694569002881 H-loop/switch region; other site 694569002882 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 694569002883 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694569002884 FMN binding site [chemical binding]; other site 694569002885 active site 694569002886 catalytic residues [active] 694569002887 substrate binding site [chemical binding]; other site 694569002888 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 694569002889 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 694569002890 putative metal binding site [ion binding]; other site 694569002891 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694569002892 HSP70 interaction site [polypeptide binding]; other site 694569002893 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569002894 active site 694569002895 ribonuclease PH; Reviewed; Region: rph; PRK00173 694569002896 Ribonuclease PH; Region: RNase_PH_bact; cd11362 694569002897 hexamer interface [polypeptide binding]; other site 694569002898 active site 694569002899 hypothetical protein; Provisional; Region: PRK11820 694569002900 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 694569002901 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 694569002902 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 694569002903 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 694569002904 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 694569002905 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 694569002906 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 694569002907 rRNA interaction site [nucleotide binding]; other site 694569002908 S8 interaction site; other site 694569002909 putative laminin-1 binding site; other site 694569002910 elongation factor Ts; Provisional; Region: tsf; PRK09377 694569002911 UBA/TS-N domain; Region: UBA; pfam00627 694569002912 Elongation factor TS; Region: EF_TS; pfam00889 694569002913 Elongation factor TS; Region: EF_TS; pfam00889 694569002914 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 694569002915 TRAM domain; Region: TRAM; pfam01938 694569002916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569002917 S-adenosylmethionine binding site [chemical binding]; other site 694569002918 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 694569002919 HD domain; Region: HD_4; pfam13328 694569002920 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 694569002921 synthetase active site [active] 694569002922 NTP binding site [chemical binding]; other site 694569002923 metal binding site [ion binding]; metal-binding site 694569002924 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 694569002925 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 694569002926 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 694569002927 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 694569002928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569002929 motif II; other site 694569002930 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694569002931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569002932 S-adenosylmethionine binding site [chemical binding]; other site 694569002933 multidrug efflux protein; Reviewed; Region: PRK09579 694569002934 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694569002935 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694569002936 HlyD family secretion protein; Region: HlyD_3; pfam13437 694569002937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 694569002938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694569002939 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 694569002940 Sporulation related domain; Region: SPOR; pfam05036 694569002941 primosome assembly protein PriA; Validated; Region: PRK05580 694569002942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569002943 ATP binding site [chemical binding]; other site 694569002944 putative Mg++ binding site [ion binding]; other site 694569002945 helicase superfamily c-terminal domain; Region: HELICc; smart00490 694569002946 nucleotide binding region [chemical binding]; other site 694569002947 ATP-binding site [chemical binding]; other site 694569002948 hypothetical protein; Provisional; Region: PRK11346 694569002949 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 694569002950 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 694569002951 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 694569002952 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 694569002953 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 694569002954 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 694569002955 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694569002956 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694569002957 putative active site [active] 694569002958 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694569002959 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694569002960 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 694569002961 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 694569002962 DNA binding site [nucleotide binding] 694569002963 catalytic residue [active] 694569002964 H2TH interface [polypeptide binding]; other site 694569002965 putative catalytic residues [active] 694569002966 turnover-facilitating residue; other site 694569002967 intercalation triad [nucleotide binding]; other site 694569002968 8OG recognition residue [nucleotide binding]; other site 694569002969 putative reading head residues; other site 694569002970 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 694569002971 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 694569002972 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 694569002973 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 694569002974 hypothetical protein; Reviewed; Region: PRK00024 694569002975 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 694569002976 MPN+ (JAMM) motif; other site 694569002977 Zinc-binding site [ion binding]; other site 694569002978 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 694569002979 Flavoprotein; Region: Flavoprotein; pfam02441 694569002980 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 694569002981 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 694569002982 trimer interface [polypeptide binding]; other site 694569002983 active site 694569002984 division inhibitor protein; Provisional; Region: slmA; PRK09480 694569002985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694569002986 hypothetical protein; Provisional; Region: PRK04966 694569002987 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 694569002988 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 694569002989 ligand binding site [chemical binding]; other site 694569002990 flexible hinge region; other site 694569002991 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 694569002992 putative switch regulator; other site 694569002993 non-specific DNA interactions [nucleotide binding]; other site 694569002994 DNA binding site [nucleotide binding] 694569002995 sequence specific DNA binding site [nucleotide binding]; other site 694569002996 putative cAMP binding site [chemical binding]; other site 694569002997 glutathione reductase; Validated; Region: PRK06116 694569002998 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694569002999 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694569003000 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 694569003001 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 694569003002 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 694569003003 Transglycosylase; Region: Transgly; pfam00912 694569003004 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 694569003005 Competence protein A; Region: Competence_A; pfam11104 694569003006 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 694569003007 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 694569003008 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 694569003009 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 694569003010 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 694569003011 shikimate kinase; Reviewed; Region: aroK; PRK00131 694569003012 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 694569003013 ADP binding site [chemical binding]; other site 694569003014 magnesium binding site [ion binding]; other site 694569003015 putative shikimate binding site; other site 694569003016 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 694569003017 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 694569003018 active site 694569003019 dimer interface [polypeptide binding]; other site 694569003020 metal binding site [ion binding]; metal-binding site 694569003021 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 694569003022 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694569003023 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 694569003024 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 694569003025 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 694569003026 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 694569003027 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694569003028 HlyD family secretion protein; Region: HlyD_3; pfam13437 694569003029 SEC-C motif; Region: SEC-C; pfam02810 694569003030 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 694569003031 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 694569003032 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 694569003033 dimer interface [polypeptide binding]; other site 694569003034 ssDNA binding site [nucleotide binding]; other site 694569003035 tetramer (dimer of dimers) interface [polypeptide binding]; other site 694569003036 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 694569003037 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 694569003038 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 694569003039 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 694569003040 HTH-like domain; Region: HTH_21; pfam13276 694569003041 Integrase core domain; Region: rve; pfam00665 694569003042 Integrase core domain; Region: rve_2; pfam13333 694569003043 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 694569003044 DNA binding residues [nucleotide binding] 694569003045 Protein of unknown function (DUF721); Region: DUF721; cl02324 694569003046 Protein of unknown function (DUF2547); Region: DUF2547; pfam10818 694569003047 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 694569003048 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 694569003049 SEC-C motif; Region: SEC-C; pfam02810 694569003050 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 694569003051 active site 694569003052 8-oxo-dGMP binding site [chemical binding]; other site 694569003053 nudix motif; other site 694569003054 metal binding site [ion binding]; metal-binding site 694569003055 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 694569003056 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 694569003057 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 694569003058 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 694569003059 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 694569003060 HIGH motif; other site 694569003061 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 694569003062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694569003063 active site 694569003064 KMSKS motif; other site 694569003065 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 694569003066 tRNA binding surface [nucleotide binding]; other site 694569003067 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 694569003068 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 694569003069 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 694569003070 active site 694569003071 NTP binding site [chemical binding]; other site 694569003072 metal binding triad [ion binding]; metal-binding site 694569003073 antibiotic binding site [chemical binding]; other site 694569003074 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 694569003075 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 694569003076 active site 694569003077 metal binding site [ion binding]; metal-binding site 694569003078 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 694569003079 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 694569003080 SurA N-terminal domain; Region: SurA_N; pfam09312 694569003081 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 694569003082 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 694569003083 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569003084 active site 694569003085 Protein of unknown function (DUF461); Region: DUF461; cl01071 694569003086 putative lysogenization regulator; Reviewed; Region: PRK00218 694569003087 adenylosuccinate lyase; Provisional; Region: PRK09285 694569003088 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 694569003089 tetramer interface [polypeptide binding]; other site 694569003090 active site 694569003091 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 694569003092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694569003093 NAD(P) binding site [chemical binding]; other site 694569003094 active site 694569003095 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 694569003096 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 694569003097 DNA binding residues [nucleotide binding] 694569003098 putative dimer interface [polypeptide binding]; other site 694569003099 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 694569003100 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 694569003101 substrate binding site [chemical binding]; other site 694569003102 catalytic Zn binding site [ion binding]; other site 694569003103 NAD binding site [chemical binding]; other site 694569003104 structural Zn binding site [ion binding]; other site 694569003105 dimer interface [polypeptide binding]; other site 694569003106 S-formylglutathione hydrolase; Region: PLN02442 694569003107 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 694569003108 signal recognition particle protein; Provisional; Region: PRK10867 694569003109 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 694569003110 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 694569003111 P loop; other site 694569003112 GTP binding site [chemical binding]; other site 694569003113 Signal peptide binding domain; Region: SRP_SPB; pfam02978 694569003114 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 694569003115 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 694569003116 Domain of unknown function DUF21; Region: DUF21; pfam01595 694569003117 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694569003118 Transporter associated domain; Region: CorC_HlyC; smart01091 694569003119 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 694569003120 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 694569003121 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 694569003122 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 694569003123 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 694569003124 Peptidase family M48; Region: Peptidase_M48; pfam01435 694569003125 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 694569003126 dimer interface [polypeptide binding]; other site 694569003127 substrate binding site [chemical binding]; other site 694569003128 metal binding sites [ion binding]; metal-binding site 694569003129 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 694569003130 aromatic amino acid transport protein; Region: araaP; TIGR00837 694569003131 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 694569003132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569003133 active site 694569003134 motif I; other site 694569003135 motif II; other site 694569003136 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 694569003137 active site 694569003138 HslU subunit interaction site [polypeptide binding]; other site 694569003139 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 694569003140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569003141 Walker A motif; other site 694569003142 ATP binding site [chemical binding]; other site 694569003143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569003144 Walker B motif; other site 694569003145 arginine finger; other site 694569003146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 694569003147 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 694569003148 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 694569003149 substrate binding site [chemical binding]; other site 694569003150 VacJ like lipoprotein; Region: VacJ; pfam04333 694569003151 hypothetical protein; Validated; Region: PRK05445 694569003152 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569003153 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569003154 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569003155 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569003156 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569003157 putative active site [active] 694569003158 catalytic site [active] 694569003159 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 694569003160 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569003161 putative active site [active] 694569003162 catalytic site [active] 694569003163 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569003164 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 694569003165 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 694569003166 folate binding site [chemical binding]; other site 694569003167 NADP+ binding site [chemical binding]; other site 694569003168 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 694569003169 Uncharacterized conserved protein [Function unknown]; Region: COG2966 694569003170 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 694569003171 gamma-glutamyl kinase; Provisional; Region: PRK05429 694569003172 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 694569003173 homotetrameric interface [polypeptide binding]; other site 694569003174 putative phosphate binding site [ion binding]; other site 694569003175 putative allosteric binding site; other site 694569003176 PUA domain; Region: PUA; pfam01472 694569003177 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694569003178 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 694569003179 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694569003180 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 694569003181 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 694569003182 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 694569003183 inhibitor-cofactor binding pocket; inhibition site 694569003184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569003185 catalytic residue [active] 694569003186 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 694569003187 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 694569003188 substrate-cofactor binding pocket; other site 694569003189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569003190 catalytic residue [active] 694569003191 Protein of unknown function (DUF452); Region: DUF452; cl01062 694569003192 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 694569003193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569003194 S-adenosylmethionine binding site [chemical binding]; other site 694569003195 AAA domain; Region: AAA_26; pfam13500 694569003196 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 694569003197 hypothetical protein; Provisional; Region: PRK11193 694569003198 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 694569003199 putative phosphate acyltransferase; Provisional; Region: PRK05331 694569003200 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 694569003201 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 694569003202 dimer interface [polypeptide binding]; other site 694569003203 active site 694569003204 CoA binding pocket [chemical binding]; other site 694569003205 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 694569003206 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 694569003207 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 694569003208 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 694569003209 NAD(P) binding site [chemical binding]; other site 694569003210 homotetramer interface [polypeptide binding]; other site 694569003211 homodimer interface [polypeptide binding]; other site 694569003212 active site 694569003213 acyl carrier protein; Provisional; Region: acpP; PRK00982 694569003214 benzoate transport; Region: 2A0115; TIGR00895 694569003215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569003216 putative substrate translocation pore; other site 694569003217 transcription termination factor Rho; Provisional; Region: rho; PRK09376 694569003218 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 694569003219 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 694569003220 RNA binding site [nucleotide binding]; other site 694569003221 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 694569003222 multimer interface [polypeptide binding]; other site 694569003223 Walker A motif; other site 694569003224 ATP binding site [chemical binding]; other site 694569003225 Walker B motif; other site 694569003226 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 694569003227 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694569003228 ATP binding site [chemical binding]; other site 694569003229 Mg++ binding site [ion binding]; other site 694569003230 motif III; other site 694569003231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569003232 nucleotide binding region [chemical binding]; other site 694569003233 ATP-binding site [chemical binding]; other site 694569003234 Oligomerisation domain; Region: Oligomerisation; cl00519 694569003235 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 694569003236 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 694569003237 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 694569003238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 694569003239 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 694569003240 rare lipoprotein A; Region: rlpA; TIGR00413 694569003241 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 694569003242 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 694569003243 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 694569003244 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 694569003245 hypothetical protein; Provisional; Region: PRK04998 694569003246 lipoate-protein ligase B; Provisional; Region: PRK14342 694569003247 lipoyl synthase; Provisional; Region: PRK05481 694569003248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569003249 FeS/SAM binding site; other site 694569003250 Patatin-like phospholipase; Region: Patatin; pfam01734 694569003251 active site 694569003252 nucleophile elbow; other site 694569003253 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 694569003254 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 694569003255 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 694569003256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694569003257 substrate binding pocket [chemical binding]; other site 694569003258 membrane-bound complex binding site; other site 694569003259 hinge residues; other site 694569003260 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 694569003261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569003262 dimer interface [polypeptide binding]; other site 694569003263 conserved gate region; other site 694569003264 putative PBP binding loops; other site 694569003265 ABC-ATPase subunit interface; other site 694569003266 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 694569003267 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 694569003268 Walker A/P-loop; other site 694569003269 ATP binding site [chemical binding]; other site 694569003270 Q-loop/lid; other site 694569003271 ABC transporter signature motif; other site 694569003272 Walker B; other site 694569003273 D-loop; other site 694569003274 H-loop/switch region; other site 694569003275 DsrH like protein; Region: DsrH; cl17347 694569003276 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 694569003277 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 694569003278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 694569003279 YheO-like PAS domain; Region: PAS_6; pfam08348 694569003280 HTH domain; Region: HTH_22; pfam13309 694569003281 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 694569003282 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 694569003283 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694569003284 hypothetical protein; Provisional; Region: PRK02119 694569003285 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 694569003286 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 694569003287 catalytic triad [active] 694569003288 dimer interface [polypeptide binding]; other site 694569003289 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 694569003290 GSH binding site [chemical binding]; other site 694569003291 catalytic residues [active] 694569003292 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 694569003293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569003294 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 694569003295 dimerization interface [polypeptide binding]; other site 694569003296 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 694569003297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 694569003298 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 694569003299 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694569003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569003301 Walker A/P-loop; other site 694569003302 ATP binding site [chemical binding]; other site 694569003303 Q-loop/lid; other site 694569003304 ABC transporter signature motif; other site 694569003305 Walker B; other site 694569003306 D-loop; other site 694569003307 H-loop/switch region; other site 694569003308 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 694569003309 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694569003310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569003311 Walker A/P-loop; other site 694569003312 ATP binding site [chemical binding]; other site 694569003313 Q-loop/lid; other site 694569003314 ABC transporter signature motif; other site 694569003315 Walker B; other site 694569003316 D-loop; other site 694569003317 H-loop/switch region; other site 694569003318 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 694569003319 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 694569003320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 694569003321 active site residue [active] 694569003322 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 694569003323 SecA binding site; other site 694569003324 Preprotein binding site; other site 694569003325 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 694569003326 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 694569003327 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 694569003328 serine acetyltransferase; Provisional; Region: cysE; PRK11132 694569003329 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 694569003330 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 694569003331 trimer interface [polypeptide binding]; other site 694569003332 active site 694569003333 substrate binding site [chemical binding]; other site 694569003334 CoA binding site [chemical binding]; other site 694569003335 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 694569003336 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 694569003337 putative active site [active] 694569003338 Protein of unknown function (DUF904); Region: DUF904; pfam06005 694569003339 FMN-binding protein MioC; Provisional; Region: PRK09004 694569003340 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 694569003341 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 694569003342 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 694569003343 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 694569003344 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 694569003345 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 694569003346 NADP binding site [chemical binding]; other site 694569003347 Predicted transcriptional regulators [Transcription]; Region: COG1733 694569003348 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 694569003349 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 694569003350 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 694569003351 F0F1 ATP synthase subunit I; Validated; Region: PRK06099 694569003352 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 694569003353 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 694569003354 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 694569003355 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 694569003356 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 694569003357 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 694569003358 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 694569003359 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 694569003360 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 694569003361 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 694569003362 beta subunit interaction interface [polypeptide binding]; other site 694569003363 Walker A motif; other site 694569003364 ATP binding site [chemical binding]; other site 694569003365 Walker B motif; other site 694569003366 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 694569003367 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 694569003368 core domain interface [polypeptide binding]; other site 694569003369 delta subunit interface [polypeptide binding]; other site 694569003370 epsilon subunit interface [polypeptide binding]; other site 694569003371 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 694569003372 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 694569003373 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 694569003374 alpha subunit interaction interface [polypeptide binding]; other site 694569003375 Walker A motif; other site 694569003376 ATP binding site [chemical binding]; other site 694569003377 Walker B motif; other site 694569003378 inhibitor binding site; inhibition site 694569003379 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 694569003380 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 694569003381 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 694569003382 gamma subunit interface [polypeptide binding]; other site 694569003383 epsilon subunit interface [polypeptide binding]; other site 694569003384 LBP interface [polypeptide binding]; other site 694569003385 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 694569003386 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 694569003387 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 694569003388 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 694569003389 putative active site [active] 694569003390 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 694569003391 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 694569003392 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 694569003393 Substrate binding site; other site 694569003394 Mg++ binding site; other site 694569003395 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 694569003396 active site 694569003397 substrate binding site [chemical binding]; other site 694569003398 CoA binding site [chemical binding]; other site 694569003399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694569003400 TPR motif; other site 694569003401 binding surface 694569003402 Uncharacterized conserved protein [Function unknown]; Region: COG1434 694569003403 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 694569003404 putative active site [active] 694569003405 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 694569003406 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 694569003407 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 694569003408 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 694569003409 intersubunit interface [polypeptide binding]; other site 694569003410 active site 694569003411 catalytic residue [active] 694569003412 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569003413 PAAR motif; Region: PAAR_motif; pfam05488 694569003414 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569003415 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569003416 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 694569003417 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569003418 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569003419 SdpI/YhfL protein family; Region: SdpI; pfam13630 694569003420 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 694569003421 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 694569003422 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 694569003423 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 694569003424 homodimer interface [polypeptide binding]; other site 694569003425 NADP binding site [chemical binding]; other site 694569003426 substrate binding site [chemical binding]; other site 694569003427 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 694569003428 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 694569003429 ring oligomerisation interface [polypeptide binding]; other site 694569003430 ATP/Mg binding site [chemical binding]; other site 694569003431 stacking interactions; other site 694569003432 hinge regions; other site 694569003433 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 694569003434 oligomerisation interface [polypeptide binding]; other site 694569003435 mobile loop; other site 694569003436 roof hairpin; other site 694569003437 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 694569003438 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 694569003439 Aspartase; Region: Aspartase; cd01357 694569003440 active sites [active] 694569003441 tetramer interface [polypeptide binding]; other site 694569003442 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694569003443 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694569003444 putative active site [active] 694569003445 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 694569003446 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 694569003447 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 694569003448 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 694569003449 active pocket/dimerization site; other site 694569003450 active site 694569003451 phosphorylation site [posttranslational modification] 694569003452 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 694569003453 active site 694569003454 phosphorylation site [posttranslational modification] 694569003455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569003456 putative transporter; Provisional; Region: PRK10504 694569003457 putative substrate translocation pore; other site 694569003458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569003459 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 694569003460 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 694569003461 Substrate binding site; other site 694569003462 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 694569003463 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 694569003464 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 694569003465 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 694569003466 Walker A/P-loop; other site 694569003467 ATP binding site [chemical binding]; other site 694569003468 Q-loop/lid; other site 694569003469 ABC transporter signature motif; other site 694569003470 Walker B; other site 694569003471 D-loop; other site 694569003472 H-loop/switch region; other site 694569003473 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694569003474 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 694569003475 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 694569003476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694569003477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 694569003478 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 694569003479 NAD(P) binding site [chemical binding]; other site 694569003480 active site 694569003481 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 694569003482 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 694569003483 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 694569003484 NADP-binding site; other site 694569003485 homotetramer interface [polypeptide binding]; other site 694569003486 substrate binding site [chemical binding]; other site 694569003487 homodimer interface [polypeptide binding]; other site 694569003488 active site 694569003489 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694569003490 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 694569003491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 694569003492 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 694569003493 putative ADP-binding pocket [chemical binding]; other site 694569003494 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 694569003495 Bacterial sugar transferase; Region: Bac_transf; pfam02397 694569003496 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 694569003497 putative dimerization interface [polypeptide binding]; other site 694569003498 Transcriptional regulators [Transcription]; Region: PurR; COG1609 694569003499 putative ligand binding site [chemical binding]; other site 694569003500 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 694569003501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 694569003502 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 694569003503 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 694569003504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694569003505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569003506 homodimer interface [polypeptide binding]; other site 694569003507 catalytic residue [active] 694569003508 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569003509 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569003510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569003511 TM-ABC transporter signature motif; other site 694569003512 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 694569003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569003514 Walker A/P-loop; other site 694569003515 ATP binding site [chemical binding]; other site 694569003516 Q-loop/lid; other site 694569003517 ABC transporter signature motif; other site 694569003518 Walker B; other site 694569003519 D-loop; other site 694569003520 H-loop/switch region; other site 694569003521 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 694569003522 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 694569003523 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 694569003524 putative ligand binding site [chemical binding]; other site 694569003525 xylose isomerase; Provisional; Region: PRK05474 694569003526 xylose isomerase; Region: xylose_isom_A; TIGR02630 694569003527 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 694569003528 N- and C-terminal domain interface [polypeptide binding]; other site 694569003529 D-xylulose kinase; Region: XylB; TIGR01312 694569003530 active site 694569003531 MgATP binding site [chemical binding]; other site 694569003532 catalytic site [active] 694569003533 metal binding site [ion binding]; metal-binding site 694569003534 xylulose binding site [chemical binding]; other site 694569003535 putative homodimer interface [polypeptide binding]; other site 694569003536 TfoX N-terminal domain; Region: TfoX_N; pfam04993 694569003537 TfoX C-terminal domain; Region: TfoX_C; pfam04994 694569003538 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 694569003539 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 694569003540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694569003541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694569003542 DNA binding residues [nucleotide binding] 694569003543 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 694569003544 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 694569003545 FAD binding domain; Region: FAD_binding_4; pfam01565 694569003546 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 694569003547 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 694569003548 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 694569003549 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 694569003550 dimerization interface [polypeptide binding]; other site 694569003551 Histidine kinase; Region: HisKA_3; pfam07730 694569003552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569003553 ATP binding site [chemical binding]; other site 694569003554 Mg2+ binding site [ion binding]; other site 694569003555 G-X-G motif; other site 694569003556 NapD protein; Region: NapD; cl01163 694569003557 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 694569003558 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 694569003559 [4Fe-4S] binding site [ion binding]; other site 694569003560 molybdopterin cofactor binding site; other site 694569003561 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 694569003562 molybdopterin cofactor binding site; other site 694569003563 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 694569003564 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 694569003565 4Fe-4S binding domain; Region: Fer4_5; pfam12801 694569003566 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694569003567 Nitrate reductase cytochrome c-type subunit [Energy production and conversion]; Region: NapB; COG3043 694569003568 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 694569003569 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 694569003570 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 694569003571 CHAP domain; Region: CHAP; pfam05257 694569003572 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 694569003573 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 694569003574 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 694569003575 putative active site [active] 694569003576 Fic family protein [Function unknown]; Region: COG3177 694569003577 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 694569003578 Fic/DOC family; Region: Fic; pfam02661 694569003579 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 694569003580 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 694569003581 NADP binding site [chemical binding]; other site 694569003582 homopentamer interface [polypeptide binding]; other site 694569003583 substrate binding site [chemical binding]; other site 694569003584 active site 694569003585 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 694569003586 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 694569003587 active site 694569003588 metal binding site [ion binding]; metal-binding site 694569003589 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 694569003590 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569003591 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 694569003592 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 694569003593 dimer interface [polypeptide binding]; other site 694569003594 active site 694569003595 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 694569003596 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 694569003597 NAD(P) binding site [chemical binding]; other site 694569003598 homotetramer interface [polypeptide binding]; other site 694569003599 homodimer interface [polypeptide binding]; other site 694569003600 active site 694569003601 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 694569003602 putative active site 1 [active] 694569003603 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 694569003604 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 694569003605 dimer interface [polypeptide binding]; other site 694569003606 active site 694569003607 Predicted exporter [General function prediction only]; Region: COG4258 694569003608 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 694569003609 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 694569003610 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 694569003611 active site 694569003612 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 694569003613 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 694569003614 putative acyl-acceptor binding pocket; other site 694569003615 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 694569003616 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 694569003617 Ligand binding site; other site 694569003618 Putative Catalytic site; other site 694569003619 DXD motif; other site 694569003620 AMP-binding enzyme; Region: AMP-binding; pfam00501 694569003621 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694569003622 active site 694569003623 AMP binding site [chemical binding]; other site 694569003624 acyl-activating enzyme (AAE) consensus motif; other site 694569003625 CoA binding site [chemical binding]; other site 694569003626 Predicted membrane protein [Function unknown]; Region: COG4648 694569003627 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 694569003628 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694569003629 AMP binding site [chemical binding]; other site 694569003630 active site 694569003631 acyl-activating enzyme (AAE) consensus motif; other site 694569003632 CoA binding site [chemical binding]; other site 694569003633 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 694569003634 active site 2 [active] 694569003635 active site 1 [active] 694569003636 acyl carrier protein; Provisional; Region: PRK05350 694569003637 Phosphopantetheine attachment site; Region: PP-binding; cl09936 694569003638 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 694569003639 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694569003640 putative acyl-acceptor binding pocket; other site 694569003641 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 694569003642 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 694569003643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569003644 motif II; other site 694569003645 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 694569003646 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 694569003647 active site 694569003648 Int/Topo IB signature motif; other site 694569003649 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 694569003650 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 694569003651 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 694569003652 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 694569003653 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 694569003654 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 694569003655 dimerization interface [polypeptide binding]; other site 694569003656 putative ATP binding site [chemical binding]; other site 694569003657 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 694569003658 Clp amino terminal domain; Region: Clp_N; pfam02861 694569003659 Clp amino terminal domain; Region: Clp_N; pfam02861 694569003660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569003661 Walker A motif; other site 694569003662 ATP binding site [chemical binding]; other site 694569003663 Walker B motif; other site 694569003664 arginine finger; other site 694569003665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569003666 Walker A motif; other site 694569003667 ATP binding site [chemical binding]; other site 694569003668 Walker B motif; other site 694569003669 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 694569003670 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 694569003671 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 694569003672 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 694569003673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569003674 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 694569003675 active site 694569003676 motif I; other site 694569003677 motif II; other site 694569003678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569003679 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 694569003680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569003681 active site 694569003682 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 694569003683 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 694569003684 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 694569003685 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 694569003686 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 694569003687 CTP synthetase; Validated; Region: pyrG; PRK05380 694569003688 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 694569003689 Catalytic site [active] 694569003690 active site 694569003691 UTP binding site [chemical binding]; other site 694569003692 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 694569003693 active site 694569003694 putative oxyanion hole; other site 694569003695 catalytic triad [active] 694569003696 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 694569003697 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 694569003698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 694569003699 Mg2+ binding site [ion binding]; other site 694569003700 G-X-G motif; other site 694569003701 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 694569003702 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 694569003703 Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; Region: COG4545 694569003704 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 694569003705 dimer interface [polypeptide binding]; other site 694569003706 motif 1; other site 694569003707 active site 694569003708 motif 2; other site 694569003709 motif 3; other site 694569003710 ferredoxin-type protein NapF; Region: napF; TIGR00402 694569003711 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 694569003712 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 694569003713 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 694569003714 4Fe-4S binding domain; Region: Fer4; cl02805 694569003715 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 694569003716 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 694569003717 putative molybdopterin cofactor binding site [chemical binding]; other site 694569003718 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 694569003719 putative molybdopterin cofactor binding site; other site 694569003720 DNA polymerase I; Provisional; Region: PRK05755 694569003721 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 694569003722 active site 694569003723 metal binding site 1 [ion binding]; metal-binding site 694569003724 putative 5' ssDNA interaction site; other site 694569003725 metal binding site 3; metal-binding site 694569003726 metal binding site 2 [ion binding]; metal-binding site 694569003727 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 694569003728 putative DNA binding site [nucleotide binding]; other site 694569003729 putative metal binding site [ion binding]; other site 694569003730 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 694569003731 active site 694569003732 catalytic site [active] 694569003733 substrate binding site [chemical binding]; other site 694569003734 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 694569003735 active site 694569003736 DNA binding site [nucleotide binding] 694569003737 catalytic site [active] 694569003738 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 694569003739 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 694569003740 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 694569003741 Part of AAA domain; Region: AAA_19; pfam13245 694569003742 Family description; Region: UvrD_C_2; pfam13538 694569003743 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 694569003744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569003745 active site 694569003746 motif I; other site 694569003747 motif II; other site 694569003748 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 694569003749 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 694569003750 active site 694569003751 substrate binding site [chemical binding]; other site 694569003752 trimer interface [polypeptide binding]; other site 694569003753 CoA binding site [chemical binding]; other site 694569003754 Predicted membrane protein [Function unknown]; Region: COG1238 694569003755 S-ribosylhomocysteinase; Provisional; Region: PRK02260 694569003756 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569003757 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 694569003758 Integrase core domain; Region: rve_3; pfam13683 694569003759 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569003760 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569003761 putative active site [active] 694569003762 catalytic site [active] 694569003763 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 694569003764 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569003765 putative active site [active] 694569003766 catalytic site [active] 694569003767 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569003768 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 694569003769 Ash protein family; Region: Phage_ASH; pfam10554 694569003770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694569003771 dimerization interface [polypeptide binding]; other site 694569003772 putative DNA binding site [nucleotide binding]; other site 694569003773 putative Zn2+ binding site [ion binding]; other site 694569003774 AntA/AntB antirepressor; Region: AntA; pfam08346 694569003775 Terminase small subunit; Region: Terminase_2; cl01513 694569003776 Helix-turn-helix domain; Region: HTH_39; pfam14090 694569003777 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 694569003778 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 694569003779 integrase; Provisional; Region: PRK09692 694569003780 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 694569003781 active site 694569003782 Int/Topo IB signature motif; other site 694569003783 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 694569003784 Dicarboxylate transport; Region: DctA-YdbH; cl14674 694569003785 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 694569003786 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 694569003787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569003788 Walker A/P-loop; other site 694569003789 ATP binding site [chemical binding]; other site 694569003790 Q-loop/lid; other site 694569003791 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569003792 ABC transporter signature motif; other site 694569003793 Walker B; other site 694569003794 D-loop; other site 694569003795 ABC transporter; Region: ABC_tran_2; pfam12848 694569003796 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 694569003797 recombinase A; Provisional; Region: recA; PRK09354 694569003798 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 694569003799 hexamer interface [polypeptide binding]; other site 694569003800 Walker A motif; other site 694569003801 ATP binding site [chemical binding]; other site 694569003802 Walker B motif; other site 694569003803 recombination regulator RecX; Reviewed; Region: recX; PRK00117 694569003804 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 694569003805 homotrimer interaction site [polypeptide binding]; other site 694569003806 putative active site [active] 694569003807 transketolase; Reviewed; Region: PRK12753 694569003808 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 694569003809 TPP-binding site [chemical binding]; other site 694569003810 dimer interface [polypeptide binding]; other site 694569003811 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694569003812 PYR/PP interface [polypeptide binding]; other site 694569003813 dimer interface [polypeptide binding]; other site 694569003814 TPP binding site [chemical binding]; other site 694569003815 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694569003816 transaldolase-like protein; Provisional; Region: PTZ00411 694569003817 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 694569003818 active site 694569003819 dimer interface [polypeptide binding]; other site 694569003820 catalytic residue [active] 694569003821 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 694569003822 Helix-turn-helix domain; Region: HTH_38; pfam13936 694569003823 Integrase core domain; Region: rve; pfam00665 694569003824 putative transposase OrfB; Reviewed; Region: PHA02517 694569003825 HTH-like domain; Region: HTH_21; pfam13276 694569003826 Integrase core domain; Region: rve; pfam00665 694569003827 Integrase core domain; Region: rve_3; pfam13683 694569003828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 694569003829 Transposase; Region: HTH_Tnp_1; cl17663 694569003830 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 694569003831 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 694569003832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694569003833 binding surface 694569003834 TPR motif; other site 694569003835 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 694569003836 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 694569003837 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 694569003838 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 694569003839 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 694569003840 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 694569003841 ATP binding site [chemical binding]; other site 694569003842 Walker A motif; other site 694569003843 hexamer interface [polypeptide binding]; other site 694569003844 Walker B motif; other site 694569003845 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 694569003846 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 694569003847 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 694569003848 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 694569003849 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 694569003850 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 694569003851 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 694569003852 metal-binding heat shock protein; Provisional; Region: PRK00016 694569003853 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 694569003854 Helicase; Region: Helicase_RecD; pfam05127 694569003855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 694569003856 Coenzyme A binding pocket [chemical binding]; other site 694569003857 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 694569003858 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 694569003859 transcription-repair coupling factor; Provisional; Region: PRK10689 694569003860 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 694569003861 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569003862 ATP binding site [chemical binding]; other site 694569003863 putative Mg++ binding site [ion binding]; other site 694569003864 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569003865 nucleotide binding region [chemical binding]; other site 694569003866 ATP-binding site [chemical binding]; other site 694569003867 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 694569003868 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 694569003869 dimer interface [polypeptide binding]; other site 694569003870 active site 694569003871 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 694569003872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569003873 Walker A/P-loop; other site 694569003874 ATP binding site [chemical binding]; other site 694569003875 Q-loop/lid; other site 694569003876 ABC transporter signature motif; other site 694569003877 Walker B; other site 694569003878 D-loop; other site 694569003879 H-loop/switch region; other site 694569003880 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 694569003881 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694569003882 substrate binding pocket [chemical binding]; other site 694569003883 membrane-bound complex binding site; other site 694569003884 hinge residues; other site 694569003885 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 694569003886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569003887 dimer interface [polypeptide binding]; other site 694569003888 conserved gate region; other site 694569003889 putative PBP binding loops; other site 694569003890 ABC-ATPase subunit interface; other site 694569003891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569003892 dimer interface [polypeptide binding]; other site 694569003893 conserved gate region; other site 694569003894 putative PBP binding loops; other site 694569003895 ABC-ATPase subunit interface; other site 694569003896 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 694569003897 Carbon starvation protein CstA; Region: CstA; pfam02554 694569003898 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 694569003899 cell division protein MraZ; Reviewed; Region: PRK00326 694569003900 MraZ protein; Region: MraZ; pfam02381 694569003901 MraZ protein; Region: MraZ; pfam02381 694569003902 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 694569003903 MraW methylase family; Region: Methyltransf_5; pfam01795 694569003904 Cell division protein [Cell division and chromosome partitioning]; Region: FtsL; COG3116 694569003905 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 694569003906 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 694569003907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 694569003908 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 694569003909 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694569003910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694569003911 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694569003912 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 694569003913 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694569003914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694569003915 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694569003916 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 694569003917 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 694569003918 Mg++ binding site [ion binding]; other site 694569003919 putative catalytic motif [active] 694569003920 putative substrate binding site [chemical binding]; other site 694569003921 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 694569003922 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 694569003923 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694569003924 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694569003925 cell division protein FtsW; Region: ftsW; TIGR02614 694569003926 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 694569003927 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 694569003928 active site 694569003929 homodimer interface [polypeptide binding]; other site 694569003930 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 694569003931 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694569003932 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694569003933 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694569003934 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 694569003935 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 694569003936 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 694569003937 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 694569003938 Cell division protein FtsQ; Region: FtsQ; pfam03799 694569003939 cell division protein FtsA; Region: ftsA; TIGR01174 694569003940 Cell division protein FtsA; Region: FtsA; smart00842 694569003941 Cell division protein FtsA; Region: FtsA; pfam14450 694569003942 cell division protein FtsZ; Validated; Region: PRK09330 694569003943 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 694569003944 nucleotide binding site [chemical binding]; other site 694569003945 SulA interaction site; other site 694569003946 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 694569003947 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 694569003948 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 694569003949 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 694569003950 Prephenate dehydratase; Region: PDT; pfam00800 694569003951 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 694569003952 putative L-Phe binding site [chemical binding]; other site 694569003953 heat shock protein 90; Provisional; Region: PRK05218 694569003954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569003955 ATP binding site [chemical binding]; other site 694569003956 Mg2+ binding site [ion binding]; other site 694569003957 G-X-G motif; other site 694569003958 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 694569003959 ArsC family; Region: ArsC; pfam03960 694569003960 putative catalytic residues [active] 694569003961 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 694569003962 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 694569003963 metal binding site [ion binding]; metal-binding site 694569003964 dimer interface [polypeptide binding]; other site 694569003965 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 694569003966 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 694569003967 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 694569003968 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 694569003969 dimer interface [polypeptide binding]; other site 694569003970 ADP-ribose binding site [chemical binding]; other site 694569003971 active site 694569003972 nudix motif; other site 694569003973 metal binding site [ion binding]; metal-binding site 694569003974 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 694569003975 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694569003976 active site 694569003977 metal binding site [ion binding]; metal-binding site 694569003978 hexamer interface [polypeptide binding]; other site 694569003979 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 694569003980 oxidoreductase; Region: PLN02991 694569003981 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 694569003982 Ligand Binding Site [chemical binding]; other site 694569003983 AAA domain; Region: AAA_14; pfam13173 694569003984 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 694569003985 hypothetical protein; Provisional; Region: PHA02961 694569003986 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 694569003987 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 694569003988 putative NAD(P) binding site [chemical binding]; other site 694569003989 putative substrate binding site [chemical binding]; other site 694569003990 catalytic Zn binding site [ion binding]; other site 694569003991 structural Zn binding site [ion binding]; other site 694569003992 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 694569003993 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 694569003994 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 694569003995 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 694569003996 putative RNA binding site [nucleotide binding]; other site 694569003997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569003998 S-adenosylmethionine binding site [chemical binding]; other site 694569003999 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 694569004000 Iron-sulfur protein interface; other site 694569004001 proximal quinone binding site [chemical binding]; other site 694569004002 C-subunit interface; other site 694569004003 distal quinone binding site; other site 694569004004 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 694569004005 D-subunit interface [polypeptide binding]; other site 694569004006 Iron-sulfur protein interface; other site 694569004007 proximal quinone binding site [chemical binding]; other site 694569004008 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 694569004009 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 694569004010 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 694569004011 L-aspartate oxidase; Provisional; Region: PRK06175 694569004012 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 694569004013 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 694569004014 poxB regulator PoxA; Provisional; Region: PRK09350 694569004015 motif 1; other site 694569004016 dimer interface [polypeptide binding]; other site 694569004017 active site 694569004018 motif 2; other site 694569004019 motif 3; other site 694569004020 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 694569004021 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694569004022 Walker A/P-loop; other site 694569004023 ATP binding site [chemical binding]; other site 694569004024 Q-loop/lid; other site 694569004025 ABC transporter signature motif; other site 694569004026 Walker B; other site 694569004027 D-loop; other site 694569004028 H-loop/switch region; other site 694569004029 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 694569004030 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569004031 ABC-ATPase subunit interface; other site 694569004032 dimer interface [polypeptide binding]; other site 694569004033 putative PBP binding regions; other site 694569004034 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 694569004035 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569004036 ABC-ATPase subunit interface; other site 694569004037 dimer interface [polypeptide binding]; other site 694569004038 putative PBP binding regions; other site 694569004039 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 694569004040 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 694569004041 siderophore binding site; other site 694569004042 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 694569004043 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694569004044 putative active site [active] 694569004045 putative metal binding site [ion binding]; other site 694569004046 hypothetical protein; Validated; Region: PRK00153 694569004047 recombination protein RecR; Reviewed; Region: recR; PRK00076 694569004048 RecR protein; Region: RecR; pfam02132 694569004049 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 694569004050 putative active site [active] 694569004051 putative metal-binding site [ion binding]; other site 694569004052 tetramer interface [polypeptide binding]; other site 694569004053 DNA topoisomerase III; Provisional; Region: PRK07726 694569004054 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 694569004055 active site 694569004056 putative interdomain interaction site [polypeptide binding]; other site 694569004057 putative metal-binding site [ion binding]; other site 694569004058 putative nucleotide binding site [chemical binding]; other site 694569004059 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 694569004060 domain I; other site 694569004061 DNA binding groove [nucleotide binding] 694569004062 phosphate binding site [ion binding]; other site 694569004063 domain II; other site 694569004064 domain III; other site 694569004065 nucleotide binding site [chemical binding]; other site 694569004066 catalytic site [active] 694569004067 domain IV; other site 694569004068 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 694569004069 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 694569004070 Transglycosylase; Region: Transgly; cl17702 694569004071 Trp operon repressor; Provisional; Region: PRK01381 694569004072 lytic murein transglycosylase; Provisional; Region: PRK11619 694569004073 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694569004074 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694569004075 catalytic residue [active] 694569004076 YciI-like protein; Reviewed; Region: PRK11370 694569004077 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 694569004078 intracellular septation protein A; Reviewed; Region: PRK00259 694569004079 OmpW family; Region: OmpW; cl17427 694569004080 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 694569004081 recombination and repair protein; Provisional; Region: PRK10869 694569004082 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 694569004083 Walker A/P-loop; other site 694569004084 ATP binding site [chemical binding]; other site 694569004085 Q-loop/lid; other site 694569004086 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 694569004087 ABC transporter signature motif; other site 694569004088 Walker B; other site 694569004089 D-loop; other site 694569004090 H-loop/switch region; other site 694569004091 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 694569004092 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 694569004093 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 694569004094 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 694569004095 dimer interface [polypeptide binding]; other site 694569004096 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 694569004097 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694569004098 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 694569004099 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 694569004100 Uncharacterized conserved protein [Function unknown]; Region: COG4121 694569004101 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 694569004102 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 694569004103 dimer interface [polypeptide binding]; other site 694569004104 active site 694569004105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 694569004106 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 694569004107 dimer interface [polypeptide binding]; other site 694569004108 phosphorylation site [posttranslational modification] 694569004109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569004110 ATP binding site [chemical binding]; other site 694569004111 Mg2+ binding site [ion binding]; other site 694569004112 G-X-G motif; other site 694569004113 Response regulator receiver domain; Region: Response_reg; pfam00072 694569004114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 694569004115 active site 694569004116 phosphorylation site [posttranslational modification] 694569004117 intermolecular recognition site; other site 694569004118 dimerization interface [polypeptide binding]; other site 694569004119 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 694569004120 putative binding surface; other site 694569004121 active site 694569004122 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 694569004123 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 694569004124 TM-ABC transporter signature motif; other site 694569004125 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 694569004126 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 694569004127 Walker A/P-loop; other site 694569004128 ATP binding site [chemical binding]; other site 694569004129 Q-loop/lid; other site 694569004130 ABC transporter signature motif; other site 694569004131 Walker B; other site 694569004132 D-loop; other site 694569004133 H-loop/switch region; other site 694569004134 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 694569004135 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 694569004136 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 694569004137 ligand binding site [chemical binding]; other site 694569004138 calcium binding site [ion binding]; other site 694569004139 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 694569004140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694569004141 DNA binding site [nucleotide binding] 694569004142 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 694569004143 ligand binding site [chemical binding]; other site 694569004144 dimerization interface (closed form) [polypeptide binding]; other site 694569004145 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 694569004146 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 694569004147 dimer interface [polypeptide binding]; other site 694569004148 active site 694569004149 galactokinase; Provisional; Region: PRK05101 694569004150 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 694569004151 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 694569004152 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694569004153 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 694569004154 active site 694569004155 catalytic residues [active] 694569004156 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 694569004157 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 694569004158 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 694569004159 transmembrane helices; other site 694569004160 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 694569004161 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 694569004162 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 694569004163 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 694569004164 citrate lyase subunit gamma; Provisional; Region: PRK13253 694569004165 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 694569004166 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 694569004167 putative active site [active] 694569004168 (T/H)XGH motif; other site 694569004169 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 694569004170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694569004171 Transporter associated domain; Region: CorC_HlyC; smart01091 694569004172 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 694569004173 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 694569004174 putative active site [active] 694569004175 catalytic triad [active] 694569004176 putative dimer interface [polypeptide binding]; other site 694569004177 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 694569004178 rRNA binding site [nucleotide binding]; other site 694569004179 predicted 30S ribosome binding site; other site 694569004180 aminopeptidase B; Provisional; Region: PRK05015 694569004181 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 694569004182 interface (dimer of trimers) [polypeptide binding]; other site 694569004183 Substrate-binding/catalytic site; other site 694569004184 Zn-binding sites [ion binding]; other site 694569004185 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 694569004186 active site 694569004187 multimer interface [polypeptide binding]; other site 694569004188 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cd02742 694569004189 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 694569004190 active site 694569004191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 694569004192 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 694569004193 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 694569004194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694569004195 Peptidase family M23; Region: Peptidase_M23; pfam01551 694569004196 Predicted membrane protein [Function unknown]; Region: COG1238 694569004197 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 694569004198 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 694569004199 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 694569004200 Permutation of conserved domain; other site 694569004201 active site 694569004202 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 694569004203 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 694569004204 substrate binding site; other site 694569004205 dimer interface; other site 694569004206 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 694569004207 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 694569004208 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 694569004209 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 694569004210 substrate binding site [chemical binding]; other site 694569004211 hexamer interface [polypeptide binding]; other site 694569004212 metal binding site [ion binding]; metal-binding site 694569004213 phosphoglycolate phosphatase; Provisional; Region: PRK13222 694569004214 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 694569004215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004216 motif II; other site 694569004217 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 694569004218 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 694569004219 active site 694569004220 HIGH motif; other site 694569004221 dimer interface [polypeptide binding]; other site 694569004222 KMSKS motif; other site 694569004223 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK01792 694569004224 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 694569004225 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 694569004226 Na2 binding site [ion binding]; other site 694569004227 putative substrate binding site 1 [chemical binding]; other site 694569004228 Na binding site 1 [ion binding]; other site 694569004229 putative substrate binding site 2 [chemical binding]; other site 694569004230 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 694569004231 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 694569004232 MgtC family; Region: MgtC; pfam02308 694569004233 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 694569004234 Helix-turn-helix domain; Region: HTH_38; pfam13936 694569004235 Integrase core domain; Region: rve; pfam00665 694569004236 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 694569004237 nucleophilic elbow; other site 694569004238 catalytic triad; other site 694569004239 YCII-related domain; Region: YCII; cl00999 694569004240 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 694569004241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694569004242 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 694569004243 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 694569004244 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 694569004245 active site 694569004246 P-loop; other site 694569004247 phosphorylation site [posttranslational modification] 694569004248 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 694569004249 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 694569004250 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 694569004251 putative substrate binding site [chemical binding]; other site 694569004252 putative ATP binding site [chemical binding]; other site 694569004253 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779 694569004254 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 694569004255 active site 694569004256 phosphorylation site [posttranslational modification] 694569004257 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 694569004258 dimerization domain swap beta strand [polypeptide binding]; other site 694569004259 regulatory protein interface [polypeptide binding]; other site 694569004260 active site 694569004261 regulatory phosphorylation site [posttranslational modification]; other site 694569004262 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 694569004263 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 694569004264 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 694569004265 GTP binding site; other site 694569004266 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 694569004267 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 694569004268 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 694569004269 catalytic residues [active] 694569004270 hinge region; other site 694569004271 alpha helical domain; other site 694569004272 hypothetical protein; Provisional; Region: PRK11027 694569004273 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 694569004274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569004275 S-adenosylmethionine binding site [chemical binding]; other site 694569004276 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 694569004277 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569004278 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569004279 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 694569004280 MutS domain I; Region: MutS_I; pfam01624 694569004281 MutS domain II; Region: MutS_II; pfam05188 694569004282 MutS domain III; Region: MutS_III; pfam05192 694569004283 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 694569004284 Walker A/P-loop; other site 694569004285 ATP binding site [chemical binding]; other site 694569004286 Q-loop/lid; other site 694569004287 ABC transporter signature motif; other site 694569004288 Walker B; other site 694569004289 D-loop; other site 694569004290 H-loop/switch region; other site 694569004291 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 694569004292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004293 active site 694569004294 motif I; other site 694569004295 motif II; other site 694569004296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004297 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 694569004298 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 694569004299 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 694569004300 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 694569004301 Predicted peptidase [General function prediction only]; Region: COG4099 694569004302 fructuronate transporter; Provisional; Region: PRK10034; cl15264 694569004303 GntP family permease; Region: GntP_permease; pfam02447 694569004304 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 694569004305 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 694569004306 Metal-binding active site; metal-binding site 694569004307 putative aldolase; Validated; Region: PRK08130 694569004308 intersubunit interface [polypeptide binding]; other site 694569004309 active site 694569004310 Zn2+ binding site [ion binding]; other site 694569004311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 694569004312 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 694569004313 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 694569004314 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 694569004315 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 694569004316 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 694569004317 Nitrogen regulatory protein P-II; Region: P-II; smart00938 694569004318 conserved hypothetical protein, YceG family; Region: TIGR00247 694569004319 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 694569004320 dimerization interface [polypeptide binding]; other site 694569004321 thymidylate kinase; Validated; Region: tmk; PRK00698 694569004322 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 694569004323 TMP-binding site; other site 694569004324 ATP-binding site [chemical binding]; other site 694569004325 DNA polymerase III subunit delta'; Validated; Region: PRK06871 694569004326 DNA polymerase III subunit delta'; Validated; Region: PRK08485 694569004327 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 694569004328 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 694569004329 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 694569004330 active site 694569004331 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 694569004332 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 694569004333 Domain of unknown function DUF21; Region: DUF21; pfam01595 694569004334 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 694569004335 Transporter associated domain; Region: CorC_HlyC; smart01091 694569004336 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569004337 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569004338 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569004339 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569004340 putative active site [active] 694569004341 catalytic site [active] 694569004342 Restriction endonuclease; Region: Mrr_cat; pfam04471 694569004343 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694569004344 catalytic core [active] 694569004345 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694569004346 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 694569004347 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 694569004348 active site 694569004349 substrate binding site [chemical binding]; other site 694569004350 metal binding site [ion binding]; metal-binding site 694569004351 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 694569004352 Peptidase family M23; Region: Peptidase_M23; pfam01551 694569004353 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 694569004354 NodB motif; other site 694569004355 putative active site [active] 694569004356 putative catalytic site [active] 694569004357 Zn binding site [ion binding]; other site 694569004358 Mg chelatase-related protein; Region: TIGR00368 694569004359 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 694569004360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569004361 Walker A motif; other site 694569004362 ATP binding site [chemical binding]; other site 694569004363 Walker B motif; other site 694569004364 arginine finger; other site 694569004365 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 694569004366 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 694569004367 GTP/Mg2+ binding site [chemical binding]; other site 694569004368 G5 box; other site 694569004369 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 694569004370 G1 box; other site 694569004371 G1 box; other site 694569004372 GTP/Mg2+ binding site [chemical binding]; other site 694569004373 Switch I region; other site 694569004374 Switch I region; other site 694569004375 G2 box; other site 694569004376 G2 box; other site 694569004377 G3 box; other site 694569004378 G3 box; other site 694569004379 Switch II region; other site 694569004380 Switch II region; other site 694569004381 G4 box; other site 694569004382 G5 box; other site 694569004383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 694569004384 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 694569004385 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 694569004386 substrate binding site [chemical binding]; other site 694569004387 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 694569004388 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 694569004389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569004390 dimer interface [polypeptide binding]; other site 694569004391 conserved gate region; other site 694569004392 ABC-ATPase subunit interface; other site 694569004393 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 694569004394 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 694569004395 Walker A/P-loop; other site 694569004396 ATP binding site [chemical binding]; other site 694569004397 Q-loop/lid; other site 694569004398 ABC transporter signature motif; other site 694569004399 Walker B; other site 694569004400 D-loop; other site 694569004401 H-loop/switch region; other site 694569004402 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 694569004403 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 694569004404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004405 active site 694569004406 motif I; other site 694569004407 motif II; other site 694569004408 Homeodomain-like domain; Region: HTH_23; cl17451 694569004409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 694569004410 Transposase; Region: HTH_Tnp_1; cl17663 694569004411 HTH-like domain; Region: HTH_21; pfam13276 694569004412 Integrase core domain; Region: rve; pfam00665 694569004413 Integrase core domain; Region: rve_3; pfam13683 694569004414 AAA domain; Region: AAA_14; pfam13173 694569004415 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 694569004416 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 694569004417 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694569004418 ATP binding site [chemical binding]; other site 694569004419 Mg++ binding site [ion binding]; other site 694569004420 motif III; other site 694569004421 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569004422 nucleotide binding region [chemical binding]; other site 694569004423 ATP-binding site [chemical binding]; other site 694569004424 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 694569004425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569004426 S-adenosylmethionine binding site [chemical binding]; other site 694569004427 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 694569004428 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694569004429 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694569004430 active site 694569004431 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569004432 Der GTPase activator; Provisional; Region: PRK05244 694569004433 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 694569004434 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 694569004435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569004436 FeS/SAM binding site; other site 694569004437 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 694569004438 triosephosphate isomerase; Provisional; Region: PRK14567 694569004439 substrate binding site [chemical binding]; other site 694569004440 dimer interface [polypeptide binding]; other site 694569004441 catalytic triad [active] 694569004442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 694569004443 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 694569004444 substrate binding site [chemical binding]; other site 694569004445 oxyanion hole (OAH) forming residues; other site 694569004446 trimer interface [polypeptide binding]; other site 694569004447 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 694569004448 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 694569004449 active site 694569004450 NTP binding site [chemical binding]; other site 694569004451 metal binding triad [ion binding]; metal-binding site 694569004452 antibiotic binding site [chemical binding]; other site 694569004453 O-succinylbenzoate synthase; Provisional; Region: PRK05105 694569004454 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 694569004455 active site 694569004456 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 694569004457 Dehydroquinase class II; Region: DHquinase_II; pfam01220 694569004458 active site 694569004459 trimer interface [polypeptide binding]; other site 694569004460 dimer interface [polypeptide binding]; other site 694569004461 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 694569004462 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 694569004463 carboxyltransferase (CT) interaction site; other site 694569004464 biotinylation site [posttranslational modification]; other site 694569004465 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 694569004466 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 694569004467 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 694569004468 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 694569004469 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 694569004470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694569004471 TPR motif; other site 694569004472 binding surface 694569004473 Protein of unknown function (DUF560); Region: DUF560; pfam04575 694569004474 Predicted membrane protein [Function unknown]; Region: COG3924 694569004475 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 694569004476 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 694569004477 Na binding site [ion binding]; other site 694569004478 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 694569004479 Fic/DOC family; Region: Fic; cl00960 694569004480 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 694569004481 Methyltransferase domain; Region: Methyltransf_18; pfam12847 694569004482 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 694569004483 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694569004484 FMN binding site [chemical binding]; other site 694569004485 active site 694569004486 catalytic residues [active] 694569004487 substrate binding site [chemical binding]; other site 694569004488 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 694569004489 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 694569004490 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 694569004491 30S subunit binding site; other site 694569004492 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 694569004493 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 694569004494 Predicted acetyltransferase [General function prediction only]; Region: COG2388 694569004495 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 694569004496 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 694569004497 CoA-binding site [chemical binding]; other site 694569004498 ATP-binding [chemical binding]; other site 694569004499 DNA gyrase inhibitor; Reviewed; Region: PRK00418 694569004500 Integrase core domain; Region: rve; pfam00665 694569004501 Integrase core domain; Region: rve_3; pfam13683 694569004502 HTH-like domain; Region: HTH_21; pfam13276 694569004503 Integrase core domain; Region: rve; pfam00665 694569004504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 694569004505 Transposase; Region: HTH_Tnp_1; cl17663 694569004506 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 694569004507 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 694569004508 ATP-grasp domain; Region: ATP-grasp_4; cl17255 694569004509 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 694569004510 Sulfatase; Region: Sulfatase; pfam00884 694569004511 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 694569004512 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 694569004513 oligomer interface [polypeptide binding]; other site 694569004514 active site residues [active] 694569004515 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 694569004516 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 694569004517 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 694569004518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569004519 Walker A motif; other site 694569004520 ATP binding site [chemical binding]; other site 694569004521 Walker B motif; other site 694569004522 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 694569004523 Helix-turn-helix domain; Region: HTH_37; pfam13744 694569004524 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 694569004525 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 694569004526 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 694569004527 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694569004528 metal-binding site [ion binding] 694569004529 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 694569004530 Soluble P-type ATPase [General function prediction only]; Region: COG4087 694569004531 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 694569004532 metal-binding site [ion binding] 694569004533 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 694569004534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 694569004535 Predicted transcriptional regulator [Transcription]; Region: COG2932 694569004536 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 694569004537 Catalytic site [active] 694569004538 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 694569004539 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 694569004540 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 694569004541 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 694569004542 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 694569004543 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 694569004544 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 694569004545 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 694569004546 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 694569004547 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 694569004548 DNA binding site [nucleotide binding] 694569004549 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 694569004550 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 694569004551 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 694569004552 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 694569004553 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 694569004554 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 694569004555 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 694569004556 RPB1 interaction site [polypeptide binding]; other site 694569004557 RPB11 interaction site [polypeptide binding]; other site 694569004558 RPB10 interaction site [polypeptide binding]; other site 694569004559 RPB3 interaction site [polypeptide binding]; other site 694569004560 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 694569004561 core dimer interface [polypeptide binding]; other site 694569004562 peripheral dimer interface [polypeptide binding]; other site 694569004563 L10 interface [polypeptide binding]; other site 694569004564 L11 interface [polypeptide binding]; other site 694569004565 putative EF-Tu interaction site [polypeptide binding]; other site 694569004566 putative EF-G interaction site [polypeptide binding]; other site 694569004567 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 694569004568 23S rRNA interface [nucleotide binding]; other site 694569004569 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 694569004570 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 694569004571 mRNA/rRNA interface [nucleotide binding]; other site 694569004572 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 694569004573 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 694569004574 23S rRNA interface [nucleotide binding]; other site 694569004575 L7/L12 interface [polypeptide binding]; other site 694569004576 putative thiostrepton binding site; other site 694569004577 L25 interface [polypeptide binding]; other site 694569004578 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 694569004579 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 694569004580 putative homodimer interface [polypeptide binding]; other site 694569004581 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 694569004582 heterodimer interface [polypeptide binding]; other site 694569004583 homodimer interface [polypeptide binding]; other site 694569004584 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 694569004585 Uncharacterized conserved protein [Function unknown]; Region: COG1359 694569004586 Uncharacterized conserved protein [Function unknown]; Region: COG1359 694569004587 FOG: WD40 repeat [General function prediction only]; Region: COG2319 694569004588 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 694569004589 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569004590 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 694569004591 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 694569004592 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 694569004593 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 694569004594 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 694569004595 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 694569004596 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 694569004597 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 694569004598 Walker A motif; other site 694569004599 ATP binding site [chemical binding]; other site 694569004600 Walker B motif; other site 694569004601 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 694569004602 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 694569004603 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 694569004604 amidase catalytic site [active] 694569004605 Zn binding residues [ion binding]; other site 694569004606 substrate binding site [chemical binding]; other site 694569004607 Domain of unknown function (DUF386); Region: DUF386; pfam04074 694569004608 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 694569004609 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 694569004610 RNase E interface [polypeptide binding]; other site 694569004611 trimer interface [polypeptide binding]; other site 694569004612 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 694569004613 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 694569004614 RNase E interface [polypeptide binding]; other site 694569004615 trimer interface [polypeptide binding]; other site 694569004616 active site 694569004617 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 694569004618 putative nucleic acid binding region [nucleotide binding]; other site 694569004619 G-X-X-G motif; other site 694569004620 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 694569004621 RNA binding site [nucleotide binding]; other site 694569004622 domain interface; other site 694569004623 lipoprotein NlpI; Provisional; Region: PRK11189 694569004624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694569004625 binding surface 694569004626 TPR motif; other site 694569004627 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 694569004628 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 694569004629 ATP binding site [chemical binding]; other site 694569004630 Mg++ binding site [ion binding]; other site 694569004631 motif III; other site 694569004632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569004633 nucleotide binding region [chemical binding]; other site 694569004634 ATP-binding site [chemical binding]; other site 694569004635 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 694569004636 putative RNA binding site [nucleotide binding]; other site 694569004637 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 694569004638 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 694569004639 Integrase core domain; Region: rve_2; pfam13333 694569004640 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 694569004641 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 694569004642 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 694569004643 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 694569004644 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 694569004645 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 694569004646 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569004647 active site 694569004648 peptidase PmbA; Provisional; Region: PRK11040 694569004649 hypothetical protein; Provisional; Region: PRK05255 694569004650 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 694569004651 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 694569004652 transmembrane helices; other site 694569004653 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 694569004654 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 694569004655 UbiA prenyltransferase family; Region: UbiA; pfam01040 694569004656 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 694569004657 homodimer interaction site [polypeptide binding]; other site 694569004658 cofactor binding site; other site 694569004659 Permease family; Region: Xan_ur_permease; pfam00860 694569004660 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569004661 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 694569004662 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 694569004663 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 694569004664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569004665 Walker A/P-loop; other site 694569004666 ATP binding site [chemical binding]; other site 694569004667 Q-loop/lid; other site 694569004668 ABC transporter signature motif; other site 694569004669 Walker B; other site 694569004670 D-loop; other site 694569004671 H-loop/switch region; other site 694569004672 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 694569004673 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 694569004674 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 694569004675 P loop; other site 694569004676 GTP binding site [chemical binding]; other site 694569004677 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 694569004678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569004679 S-adenosylmethionine binding site [chemical binding]; other site 694569004680 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 694569004681 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 694569004682 active pocket/dimerization site; other site 694569004683 active site 694569004684 phosphorylation site [posttranslational modification] 694569004685 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 694569004686 active site 694569004687 phosphorylation site [posttranslational modification] 694569004688 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 694569004689 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 694569004690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004691 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 694569004692 active site 694569004693 motif I; other site 694569004694 motif II; other site 694569004695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004696 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 694569004697 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 694569004698 Nucleoside recognition; Region: Gate; pfam07670 694569004699 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 694569004700 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 694569004701 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 694569004702 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 694569004703 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 694569004704 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 694569004705 DXD motif; other site 694569004706 PgaD-like protein; Region: PgaD; cl14676 694569004707 regulatory protein UhpC; Provisional; Region: PRK11663 694569004708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569004709 putative substrate translocation pore; other site 694569004710 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 694569004711 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 694569004712 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 694569004713 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 694569004714 Integrase core domain; Region: rve; pfam00665 694569004715 Integrase core domain; Region: rve_2; pfam13333 694569004716 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 694569004717 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 694569004718 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 694569004719 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 694569004720 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 694569004721 catalytic site [active] 694569004722 G-X2-G-X-G-K; other site 694569004723 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 694569004724 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 694569004725 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 694569004726 Zn2+ binding site [ion binding]; other site 694569004727 Mg2+ binding site [ion binding]; other site 694569004728 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 694569004729 synthetase active site [active] 694569004730 NTP binding site [chemical binding]; other site 694569004731 metal binding site [ion binding]; metal-binding site 694569004732 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 694569004733 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 694569004734 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 694569004735 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 694569004736 generic binding surface II; other site 694569004737 ssDNA binding site; other site 694569004738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569004739 ATP binding site [chemical binding]; other site 694569004740 putative Mg++ binding site [ion binding]; other site 694569004741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569004742 nucleotide binding region [chemical binding]; other site 694569004743 ATP-binding site [chemical binding]; other site 694569004744 Chorismate lyase; Region: Chor_lyase; cl01230 694569004745 glutamate racemase; Provisional; Region: PRK00865 694569004746 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 694569004747 active site 694569004748 catalytic residues [active] 694569004749 metal binding site [ion binding]; metal-binding site 694569004750 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 694569004751 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 694569004752 putative active site [active] 694569004753 substrate binding site [chemical binding]; other site 694569004754 putative cosubstrate binding site; other site 694569004755 catalytic site [active] 694569004756 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 694569004757 substrate binding site [chemical binding]; other site 694569004758 16S rRNA methyltransferase B; Provisional; Region: PRK10901 694569004759 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 694569004760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569004761 S-adenosylmethionine binding site [chemical binding]; other site 694569004762 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 694569004763 TrkA-N domain; Region: TrkA_N; pfam02254 694569004764 TrkA-C domain; Region: TrkA_C; pfam02080 694569004765 TrkA-N domain; Region: TrkA_N; pfam02254 694569004766 TrkA-C domain; Region: TrkA_C; pfam02080 694569004767 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 694569004768 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 694569004769 RNase E inhibitor protein; Provisional; Region: PRK11191 694569004770 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 694569004771 Protein of unknown function (DUF541); Region: SIMPL; cl01077 694569004772 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 694569004773 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694569004774 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 694569004775 Low molecular weight phosphatase family; Region: LMWPc; cd00115 694569004776 active site 694569004777 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 694569004778 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 694569004779 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569004780 FeS/SAM binding site; other site 694569004781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 694569004782 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 694569004783 ArsC family; Region: ArsC; pfam03960 694569004784 catalytic residues [active] 694569004785 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 694569004786 Domain of unknown function DUF20; Region: UPF0118; pfam01594 694569004787 uridine phosphorylase; Provisional; Region: PRK11178 694569004788 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 694569004789 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 694569004790 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 694569004791 putative DNA binding site [nucleotide binding]; other site 694569004792 putative Zn2+ binding site [ion binding]; other site 694569004793 AsnC family; Region: AsnC_trans_reg; pfam01037 694569004794 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 694569004795 dimer interface [polypeptide binding]; other site 694569004796 active site 694569004797 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 694569004798 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 694569004799 FMN binding site [chemical binding]; other site 694569004800 active site 694569004801 catalytic residues [active] 694569004802 substrate binding site [chemical binding]; other site 694569004803 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 694569004804 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 694569004805 putative ion selectivity filter; other site 694569004806 putative pore gating glutamate residue; other site 694569004807 putative H+/Cl- coupling transport residue; other site 694569004808 ornithine carbamoyltransferase; Provisional; Region: PRK01713 694569004809 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 694569004810 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 694569004811 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 694569004812 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 694569004813 putative substrate binding site [chemical binding]; other site 694569004814 nucleotide binding site [chemical binding]; other site 694569004815 nucleotide binding site [chemical binding]; other site 694569004816 homodimer interface [polypeptide binding]; other site 694569004817 Predicted membrane protein [Function unknown]; Region: COG1288 694569004818 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 694569004819 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 694569004820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694569004821 putative DNA binding site [nucleotide binding]; other site 694569004822 dimerization interface [polypeptide binding]; other site 694569004823 putative Zn2+ binding site [ion binding]; other site 694569004824 AsnC family; Region: AsnC_trans_reg; pfam01037 694569004825 putative acyltransferase; Provisional; Region: PRK05790 694569004826 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 694569004827 dimer interface [polypeptide binding]; other site 694569004828 active site 694569004829 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 694569004830 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 694569004831 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 694569004832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 694569004833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 694569004834 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 694569004835 dimerization interface [polypeptide binding]; other site 694569004836 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 694569004837 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 694569004838 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 694569004839 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 694569004840 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 694569004841 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 694569004842 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 694569004843 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 694569004844 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 694569004845 protein-rRNA interface [nucleotide binding]; other site 694569004846 putative translocon binding site; other site 694569004847 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 694569004848 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 694569004849 G-X-X-G motif; other site 694569004850 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 694569004851 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 694569004852 23S rRNA interface [nucleotide binding]; other site 694569004853 5S rRNA interface [nucleotide binding]; other site 694569004854 putative antibiotic binding site [chemical binding]; other site 694569004855 L25 interface [polypeptide binding]; other site 694569004856 L27 interface [polypeptide binding]; other site 694569004857 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 694569004858 23S rRNA interface [nucleotide binding]; other site 694569004859 putative translocon interaction site; other site 694569004860 signal recognition particle (SRP54) interaction site; other site 694569004861 L23 interface [polypeptide binding]; other site 694569004862 trigger factor interaction site; other site 694569004863 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 694569004864 putative transposase OrfB; Reviewed; Region: PHA02517 694569004865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 694569004866 Transposase; Region: HTH_Tnp_1; cl17663 694569004867 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 694569004868 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 694569004869 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 694569004870 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 694569004871 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 694569004872 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 694569004873 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 694569004874 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 694569004875 DNA binding residues [nucleotide binding] 694569004876 DNA primase; Validated; Region: dnaG; PRK05667 694569004877 CHC2 zinc finger; Region: zf-CHC2; pfam01807 694569004878 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 694569004879 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 694569004880 active site 694569004881 metal binding site [ion binding]; metal-binding site 694569004882 interdomain interaction site; other site 694569004883 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 694569004884 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 694569004885 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 694569004886 UGMP family protein; Validated; Region: PRK09604 694569004887 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 694569004888 thymidine kinase; Provisional; Region: PRK04296 694569004889 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 694569004890 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 694569004891 nucleotide binding pocket [chemical binding]; other site 694569004892 K-X-D-G motif; other site 694569004893 catalytic site [active] 694569004894 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 694569004895 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 694569004896 Helix-hairpin-helix motif; Region: HHH; pfam00633 694569004897 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 694569004898 Dimer interface [polypeptide binding]; other site 694569004899 BRCT sequence motif; other site 694569004900 cell division protein ZipA; Provisional; Region: PRK01741 694569004901 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 694569004902 FtsZ protein binding site [polypeptide binding]; other site 694569004903 putative sulfate transport protein CysZ; Validated; Region: PRK04949 694569004904 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 694569004905 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 694569004906 dimer interface [polypeptide binding]; other site 694569004907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569004908 catalytic residue [active] 694569004909 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 694569004910 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 694569004911 putative uracil binding site [chemical binding]; other site 694569004912 putative active site [active] 694569004913 GTP-binding protein YchF; Reviewed; Region: PRK09601 694569004914 YchF GTPase; Region: YchF; cd01900 694569004915 G1 box; other site 694569004916 GTP/Mg2+ binding site [chemical binding]; other site 694569004917 Switch I region; other site 694569004918 G2 box; other site 694569004919 Switch II region; other site 694569004920 G3 box; other site 694569004921 G4 box; other site 694569004922 G5 box; other site 694569004923 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 694569004924 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 694569004925 putative active site [active] 694569004926 catalytic residue [active] 694569004927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 694569004928 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 694569004929 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 694569004930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 694569004931 motif II; other site 694569004932 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 694569004933 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 694569004934 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 694569004935 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 694569004936 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 694569004937 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 694569004938 active site 694569004939 Riboflavin kinase; Region: Flavokinase; smart00904 694569004940 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 694569004941 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 694569004942 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 694569004943 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694569004944 active site 694569004945 HIGH motif; other site 694569004946 nucleotide binding site [chemical binding]; other site 694569004947 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 694569004948 active site 694569004949 KMSKS motif; other site 694569004950 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 694569004951 tRNA binding surface [nucleotide binding]; other site 694569004952 anticodon binding site; other site 694569004953 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 694569004954 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 694569004955 lipoprotein signal peptidase; Provisional; Region: PRK14787 694569004956 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 694569004957 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 694569004958 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 694569004959 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 694569004960 active site 694569004961 dimerization interface [polypeptide binding]; other site 694569004962 Uncharacterized conserved protein [Function unknown]; Region: COG0393 694569004963 HemN family oxidoreductase; Provisional; Region: PRK05660 694569004964 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569004965 FeS/SAM binding site; other site 694569004966 HemN C-terminal domain; Region: HemN_C; pfam06969 694569004967 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 694569004968 tetramer (dimer of dimers) interface [polypeptide binding]; other site 694569004969 active site 694569004970 dimer interface [polypeptide binding]; other site 694569004971 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 694569004972 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 694569004973 ligand binding site [chemical binding]; other site 694569004974 NAD binding site [chemical binding]; other site 694569004975 tetramer interface [polypeptide binding]; other site 694569004976 catalytic site [active] 694569004977 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 694569004978 L-serine binding site [chemical binding]; other site 694569004979 ACT domain interface; other site 694569004980 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 694569004981 putative ligand binding residues [chemical binding]; other site 694569004982 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 694569004983 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 694569004984 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 694569004985 active site 694569004986 intersubunit interface [polypeptide binding]; other site 694569004987 catalytic residue [active] 694569004988 Glucuronate isomerase; Region: UxaC; pfam02614 694569004989 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 694569004990 D-mannonate oxidoreductase; Provisional; Region: PRK08277 694569004991 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 694569004992 putative NAD(P) binding site [chemical binding]; other site 694569004993 active site 694569004994 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 694569004995 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 694569004996 substrate binding site [chemical binding]; other site 694569004997 ATP binding site [chemical binding]; other site 694569004998 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 694569004999 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 694569005000 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 694569005001 DctM-like transporters; Region: DctM; pfam06808 694569005002 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 694569005003 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 694569005004 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 694569005005 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 694569005006 putative active site [active] 694569005007 putative catalytic site [active] 694569005008 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 694569005009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 694569005010 DNA-binding site [nucleotide binding]; DNA binding site 694569005011 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 694569005012 mannonate dehydratase; Provisional; Region: PRK03906 694569005013 mannonate dehydratase; Region: uxuA; TIGR00695 694569005014 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694569005015 EamA-like transporter family; Region: EamA; pfam00892 694569005016 EamA-like transporter family; Region: EamA; pfam00892 694569005017 putative transporter; Provisional; Region: PRK11660 694569005018 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 694569005019 Sulfate transporter family; Region: Sulfate_transp; pfam00916 694569005020 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 694569005021 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 694569005022 Found in ATP-dependent protease La (LON); Region: LON; smart00464 694569005023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569005024 Walker A motif; other site 694569005025 ATP binding site [chemical binding]; other site 694569005026 Walker B motif; other site 694569005027 arginine finger; other site 694569005028 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 694569005029 periplasmic folding chaperone; Provisional; Region: PRK10788 694569005030 SurA N-terminal domain; Region: SurA_N_3; cl07813 694569005031 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 694569005032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 694569005033 active site 694569005034 uracil-xanthine permease; Region: ncs2; TIGR00801 694569005035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 694569005036 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 694569005037 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 694569005038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 694569005039 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 694569005040 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 694569005041 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 694569005042 dimer interface [polypeptide binding]; other site 694569005043 motif 1; other site 694569005044 active site 694569005045 motif 2; other site 694569005046 motif 3; other site 694569005047 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 694569005048 anticodon binding site; other site 694569005049 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 694569005050 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 694569005051 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 694569005052 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 694569005053 Helix-turn-helix domain; Region: HTH_25; pfam13413 694569005054 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 694569005055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 694569005056 binding surface 694569005057 TPR motif; other site 694569005058 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 694569005059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569005060 FeS/SAM binding site; other site 694569005061 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 694569005062 active site 694569005063 homodimer interface [polypeptide binding]; other site 694569005064 homotetramer interface [polypeptide binding]; other site 694569005065 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 694569005066 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 694569005067 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 694569005068 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 694569005069 serine transporter; Region: stp; TIGR00814 694569005070 hypothetical protein; Provisional; Region: PRK04860 694569005071 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 694569005072 Integrase core domain; Region: rve; pfam00665 694569005073 Integrase core domain; Region: rve_2; pfam13333 694569005074 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569005075 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 694569005076 Malic enzyme, N-terminal domain; Region: malic; pfam00390 694569005077 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 694569005078 putative NAD(P) binding site [chemical binding]; other site 694569005079 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 694569005080 superoxide dismutase; Provisional; Region: PRK10925 694569005081 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 694569005082 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 694569005083 Lipoprotein GNA1870 C terminal like; Region: Lipoprot_C; pfam08794 694569005084 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 694569005085 Predicted metalloprotease [General function prediction only]; Region: COG2321 694569005086 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 694569005087 BON domain; Region: BON; pfam04972 694569005088 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694569005089 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 694569005090 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 694569005091 homooctamer interface [polypeptide binding]; other site 694569005092 active site 694569005093 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 694569005094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 694569005095 substrate binding pocket [chemical binding]; other site 694569005096 membrane-bound complex binding site; other site 694569005097 hinge residues; other site 694569005098 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694569005099 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694569005100 catalytic residue [active] 694569005101 disulfide bond formation protein B; Provisional; Region: PRK01749 694569005102 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 694569005103 fatty acid metabolism regulator; Provisional; Region: PRK04984 694569005104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 694569005105 DNA-binding site [nucleotide binding]; DNA binding site 694569005106 FadR C-terminal domain; Region: FadR_C; pfam07840 694569005107 aminotransferase AlaT; Validated; Region: PRK09265 694569005108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 694569005109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569005110 homodimer interface [polypeptide binding]; other site 694569005111 catalytic residue [active] 694569005112 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 694569005113 chorismate binding enzyme; Region: Chorismate_bind; cl10555 694569005114 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 694569005115 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 694569005116 dimer interface [polypeptide binding]; other site 694569005117 tetramer interface [polypeptide binding]; other site 694569005118 PYR/PP interface [polypeptide binding]; other site 694569005119 TPP binding site [chemical binding]; other site 694569005120 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 694569005121 TPP-binding site; other site 694569005122 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 694569005123 Putative serine esterase (DUF676); Region: DUF676; pfam05057 694569005124 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 694569005125 16S/18S rRNA binding site [nucleotide binding]; other site 694569005126 S13e-L30e interaction site [polypeptide binding]; other site 694569005127 25S rRNA binding site [nucleotide binding]; other site 694569005128 S-adenosylmethionine synthetase; Validated; Region: PRK05250 694569005129 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 694569005130 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 694569005131 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 694569005132 HTH-like domain; Region: HTH_21; pfam13276 694569005133 Integrase core domain; Region: rve; pfam00665 694569005134 Integrase core domain; Region: rve_2; pfam13333 694569005135 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569005136 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 694569005137 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 694569005138 RNA binding surface [nucleotide binding]; other site 694569005139 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 694569005140 active site 694569005141 uracil binding [chemical binding]; other site 694569005142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569005143 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 694569005144 putative substrate translocation pore; other site 694569005145 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 694569005146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569005147 Walker A/P-loop; other site 694569005148 ATP binding site [chemical binding]; other site 694569005149 Q-loop/lid; other site 694569005150 ABC transporter signature motif; other site 694569005151 Walker B; other site 694569005152 D-loop; other site 694569005153 H-loop/switch region; other site 694569005154 heme exporter protein CcmB; Region: ccmB; TIGR01190 694569005155 heme exporter protein CcmC; Region: ccmC; TIGR01191 694569005156 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 694569005157 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 694569005158 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 694569005159 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 694569005160 catalytic residues [active] 694569005161 central insert; other site 694569005162 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 694569005163 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 694569005164 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 694569005165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694569005166 TPR motif; other site 694569005167 binding surface 694569005168 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 694569005169 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 694569005170 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 694569005171 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 694569005172 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 694569005173 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 694569005174 cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145 694569005175 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 694569005176 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 694569005177 catalytic residues [active] 694569005178 central insert; other site 694569005179 cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147 694569005180 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 694569005181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 694569005182 binding surface 694569005183 Predicted flavoproteins [General function prediction only]; Region: COG2081 694569005184 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694569005185 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 694569005186 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 694569005187 E-class dimer interface [polypeptide binding]; other site 694569005188 P-class dimer interface [polypeptide binding]; other site 694569005189 active site 694569005190 Cu2+ binding site [ion binding]; other site 694569005191 Zn2+ binding site [ion binding]; other site 694569005192 Methyltransferase domain; Region: Methyltransf_31; pfam13847 694569005193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569005194 S-adenosylmethionine binding site [chemical binding]; other site 694569005195 recF protein; Region: recf; TIGR00611 694569005196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569005197 Walker A/P-loop; other site 694569005198 ATP binding site [chemical binding]; other site 694569005199 Q-loop/lid; other site 694569005200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569005201 ABC transporter signature motif; other site 694569005202 Walker B; other site 694569005203 D-loop; other site 694569005204 H-loop/switch region; other site 694569005205 DNA polymerase III subunit beta; Validated; Region: PRK05643 694569005206 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 694569005207 putative DNA binding surface [nucleotide binding]; other site 694569005208 dimer interface [polypeptide binding]; other site 694569005209 beta-clamp/clamp loader binding surface; other site 694569005210 beta-clamp/translesion DNA polymerase binding surface; other site 694569005211 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 694569005212 DnaA N-terminal domain; Region: DnaA_N; pfam11638 694569005213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569005214 Walker B motif; other site 694569005215 arginine finger; other site 694569005216 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 694569005217 DnaA box-binding interface [nucleotide binding]; other site 694569005218 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 694569005219 ribonuclease P; Reviewed; Region: rnpA; PRK01732 694569005220 membrane protein insertase; Provisional; Region: PRK01318 694569005221 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 694569005222 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 694569005223 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 694569005224 trmE is a tRNA modification GTPase; Region: trmE; cd04164 694569005225 G1 box; other site 694569005226 GTP/Mg2+ binding site [chemical binding]; other site 694569005227 Switch I region; other site 694569005228 G2 box; other site 694569005229 Switch II region; other site 694569005230 G3 box; other site 694569005231 G4 box; other site 694569005232 G5 box; other site 694569005233 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 694569005234 GTPase Era; Reviewed; Region: era; PRK00089 694569005235 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 694569005236 G1 box; other site 694569005237 GTP/Mg2+ binding site [chemical binding]; other site 694569005238 Switch I region; other site 694569005239 G2 box; other site 694569005240 Switch II region; other site 694569005241 G3 box; other site 694569005242 G4 box; other site 694569005243 G5 box; other site 694569005244 KH domain; Region: KH_2; pfam07650 694569005245 ribonuclease III; Reviewed; Region: rnc; PRK00102 694569005246 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 694569005247 dimerization interface [polypeptide binding]; other site 694569005248 active site 694569005249 metal binding site [ion binding]; metal-binding site 694569005250 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 694569005251 dsRNA binding site [nucleotide binding]; other site 694569005252 signal peptidase I; Provisional; Region: PRK10861 694569005253 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694569005254 Catalytic site [active] 694569005255 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 694569005256 Catalytic site [active] 694569005257 GTP-binding protein LepA; Provisional; Region: PRK05433 694569005258 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 694569005259 G1 box; other site 694569005260 putative GEF interaction site [polypeptide binding]; other site 694569005261 GTP/Mg2+ binding site [chemical binding]; other site 694569005262 Switch I region; other site 694569005263 G2 box; other site 694569005264 G3 box; other site 694569005265 Switch II region; other site 694569005266 G4 box; other site 694569005267 G5 box; other site 694569005268 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 694569005269 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 694569005270 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 694569005271 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 694569005272 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 694569005273 ligand binding site [chemical binding]; other site 694569005274 active site 694569005275 UGI interface [polypeptide binding]; other site 694569005276 catalytic site [active] 694569005277 hypothetical protein; Validated; Region: PRK02101 694569005278 Cation efflux family; Region: Cation_efflux; cl00316 694569005279 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 694569005280 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 694569005281 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 694569005282 active site 694569005283 ADP/pyrophosphate binding site [chemical binding]; other site 694569005284 dimerization interface [polypeptide binding]; other site 694569005285 allosteric effector site; other site 694569005286 fructose-1,6-bisphosphate binding site; other site 694569005287 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 694569005288 beta-hexosaminidase; Provisional; Region: PRK05337 694569005289 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 694569005290 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 694569005291 putative dimer interface [polypeptide binding]; other site 694569005292 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 694569005293 nucleotide binding site/active site [active] 694569005294 HIT family signature motif; other site 694569005295 catalytic residue [active] 694569005296 formate transporter FocA; Region: formate_focA; TIGR04060 694569005297 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 694569005298 Pyruvate formate lyase 1; Region: PFL1; cd01678 694569005299 coenzyme A binding site [chemical binding]; other site 694569005300 active site 694569005301 catalytic residues [active] 694569005302 glycine loop; other site 694569005303 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 694569005304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569005305 FeS/SAM binding site; other site 694569005306 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694569005307 EamA-like transporter family; Region: EamA; pfam00892 694569005308 EamA-like transporter family; Region: EamA; pfam00892 694569005309 FtsI repressor; Provisional; Region: PRK10883 694569005310 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 694569005311 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 694569005312 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 694569005313 putative acyl-acceptor binding pocket; other site 694569005314 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 694569005315 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 694569005316 putative active site [active] 694569005317 putative metal binding site [ion binding]; other site 694569005318 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 694569005319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 694569005320 YheO-like PAS domain; Region: PAS_6; pfam08348 694569005321 HTH domain; Region: HTH_22; pfam13309 694569005322 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 694569005323 aromatic amino acid transport protein; Region: araaP; TIGR00837 694569005324 tyrosine phenol-lyase; Provisional; Region: PRK13237 694569005325 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 694569005326 substrate binding site [chemical binding]; other site 694569005327 tetramer interface [polypeptide binding]; other site 694569005328 catalytic residue [active] 694569005329 elongation factor P; Validated; Region: PRK00529 694569005330 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 694569005331 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 694569005332 RNA binding site [nucleotide binding]; other site 694569005333 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 694569005334 RNA binding site [nucleotide binding]; other site 694569005335 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 694569005336 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569005337 FeS/SAM binding site; other site 694569005338 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 694569005339 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 694569005340 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 694569005341 recombination associated protein; Reviewed; Region: rdgC; PRK00321 694569005342 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 694569005343 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 694569005344 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 694569005345 active site 694569005346 Int/Topo IB signature motif; other site 694569005347 trigger factor; Provisional; Region: tig; PRK01490 694569005348 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 694569005349 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 694569005350 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 694569005351 FtsH protease regulator HflC; Provisional; Region: PRK11029 694569005352 FtsH protease regulator HflK; Provisional; Region: PRK10930 694569005353 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 694569005354 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 694569005355 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 694569005356 threonine synthase; Validated; Region: PRK09225 694569005357 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 694569005358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694569005359 catalytic residue [active] 694569005360 homoserine kinase; Provisional; Region: PRK01212 694569005361 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 694569005362 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 694569005363 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 694569005364 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 694569005365 nucleotide binding site [chemical binding]; other site 694569005366 substrate binding site [chemical binding]; other site 694569005367 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 694569005368 dimer interface [polypeptide binding]; other site 694569005369 putative threonine allosteric regulatory site; other site 694569005370 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 694569005371 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 694569005372 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 694569005373 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 694569005374 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 694569005375 active site 694569005376 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 694569005377 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694569005378 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 694569005379 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 694569005380 Walker A/P-loop; other site 694569005381 ATP binding site [chemical binding]; other site 694569005382 Q-loop/lid; other site 694569005383 ABC transporter signature motif; other site 694569005384 Walker B; other site 694569005385 D-loop; other site 694569005386 H-loop/switch region; other site 694569005387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005388 dimer interface [polypeptide binding]; other site 694569005389 conserved gate region; other site 694569005390 ABC-ATPase subunit interface; other site 694569005391 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 694569005392 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 694569005393 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 694569005394 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 694569005395 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 694569005396 dihydrodipicolinate synthase; Region: dapA; TIGR00674 694569005397 dimer interface [polypeptide binding]; other site 694569005398 active site 694569005399 catalytic residue [active] 694569005400 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 694569005401 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 694569005402 catalytic triad [active] 694569005403 Autotransporter beta-domain; Region: Autotransporter; pfam03797 694569005404 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 694569005405 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 694569005406 G1 box; other site 694569005407 putative GEF interaction site [polypeptide binding]; other site 694569005408 GTP/Mg2+ binding site [chemical binding]; other site 694569005409 Switch I region; other site 694569005410 G2 box; other site 694569005411 G3 box; other site 694569005412 Switch II region; other site 694569005413 G4 box; other site 694569005414 G5 box; other site 694569005415 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 694569005416 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 694569005417 glutamine synthetase; Provisional; Region: glnA; PRK09469 694569005418 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 694569005419 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 694569005420 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 694569005421 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 694569005422 putative DNA-binding cleft [nucleotide binding]; other site 694569005423 putative DNA clevage site; other site 694569005424 molecular lever; other site 694569005425 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 694569005426 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 694569005427 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 694569005428 DNA binding site [nucleotide binding] 694569005429 active site 694569005430 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 694569005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 694569005432 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 694569005433 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 694569005434 hinge; other site 694569005435 active site 694569005436 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 694569005437 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 694569005438 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 694569005439 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 694569005440 mce related protein; Region: MCE; pfam02470 694569005441 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 694569005442 conserved hypothetical integral membrane protein; Region: TIGR00056 694569005443 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 694569005444 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 694569005445 Walker A/P-loop; other site 694569005446 ATP binding site [chemical binding]; other site 694569005447 Q-loop/lid; other site 694569005448 ABC transporter signature motif; other site 694569005449 Walker B; other site 694569005450 D-loop; other site 694569005451 H-loop/switch region; other site 694569005452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 694569005453 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 694569005454 OstA-like protein; Region: OstA; cl00844 694569005455 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 694569005456 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 694569005457 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 694569005458 Walker A/P-loop; other site 694569005459 ATP binding site [chemical binding]; other site 694569005460 Q-loop/lid; other site 694569005461 ABC transporter signature motif; other site 694569005462 Walker B; other site 694569005463 D-loop; other site 694569005464 H-loop/switch region; other site 694569005465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 694569005466 active site 694569005467 phosphorylation site [posttranslational modification] 694569005468 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 694569005469 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 694569005470 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 694569005471 generic binding surface II; other site 694569005472 generic binding surface I; other site 694569005473 Uncharacterized conserved protein [Function unknown]; Region: COG2850 694569005474 hypothetical protein; Validated; Region: PRK01777 694569005475 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 694569005476 putative coenzyme Q binding site [chemical binding]; other site 694569005477 Predicted membrane protein [Function unknown]; Region: COG2510 694569005478 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 694569005479 ABC-type Zn2+ transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: ZnuA; COG4531 694569005480 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 694569005481 metal binding site [ion binding]; metal-binding site 694569005482 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 694569005483 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 694569005484 putative ATP binding site [chemical binding]; other site 694569005485 putative substrate interface [chemical binding]; other site 694569005486 murein transglycosylase A; Provisional; Region: mltA; PRK11162 694569005487 MltA specific insert domain; Region: MltA; smart00925 694569005488 3D domain; Region: 3D; pfam06725 694569005489 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 694569005490 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 694569005491 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694569005492 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 694569005493 AMP binding site [chemical binding]; other site 694569005494 metal binding site [ion binding]; metal-binding site 694569005495 active site 694569005496 Predicted membrane protein [Function unknown]; Region: COG2860 694569005497 UPF0126 domain; Region: UPF0126; pfam03458 694569005498 UPF0126 domain; Region: UPF0126; pfam03458 694569005499 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 694569005500 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 694569005501 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 694569005502 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 694569005503 Walker A/P-loop; other site 694569005504 ATP binding site [chemical binding]; other site 694569005505 Q-loop/lid; other site 694569005506 ABC transporter signature motif; other site 694569005507 Walker B; other site 694569005508 D-loop; other site 694569005509 H-loop/switch region; other site 694569005510 TOBE domain; Region: TOBE_2; pfam08402 694569005511 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 694569005512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005513 dimer interface [polypeptide binding]; other site 694569005514 conserved gate region; other site 694569005515 putative PBP binding loops; other site 694569005516 ABC-ATPase subunit interface; other site 694569005517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005518 dimer interface [polypeptide binding]; other site 694569005519 conserved gate region; other site 694569005520 putative PBP binding loops; other site 694569005521 ABC-ATPase subunit interface; other site 694569005522 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 694569005523 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 694569005524 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 694569005525 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 694569005526 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 694569005527 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 694569005528 Sugar specificity; other site 694569005529 Pyrimidine base specificity; other site 694569005530 ATP-binding site [chemical binding]; other site 694569005531 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 694569005532 trimer interface [polypeptide binding]; other site 694569005533 active site 694569005534 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 694569005535 putative arabinose transporter; Provisional; Region: PRK03545 694569005536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 694569005537 putative substrate translocation pore; other site 694569005538 GTP-binding protein Der; Reviewed; Region: PRK00093 694569005539 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 694569005540 G1 box; other site 694569005541 GTP/Mg2+ binding site [chemical binding]; other site 694569005542 Switch I region; other site 694569005543 G2 box; other site 694569005544 Switch II region; other site 694569005545 G3 box; other site 694569005546 G4 box; other site 694569005547 G5 box; other site 694569005548 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 694569005549 G1 box; other site 694569005550 GTP/Mg2+ binding site [chemical binding]; other site 694569005551 Switch I region; other site 694569005552 G2 box; other site 694569005553 G3 box; other site 694569005554 Switch II region; other site 694569005555 G4 box; other site 694569005556 G5 box; other site 694569005557 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694569005558 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 694569005559 HSP70 interaction site [polypeptide binding]; other site 694569005560 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 694569005561 substrate binding site [polypeptide binding]; other site 694569005562 dimer interface [polypeptide binding]; other site 694569005563 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 694569005564 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 694569005565 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 694569005566 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 694569005567 GDP-binding site [chemical binding]; other site 694569005568 ACT binding site; other site 694569005569 IMP binding site; other site 694569005570 Methyltransferase domain; Region: Methyltransf_23; pfam13489 694569005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569005572 S-adenosylmethionine binding site [chemical binding]; other site 694569005573 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 694569005574 Na binding site [ion binding]; other site 694569005575 ribonuclease G; Provisional; Region: PRK11712 694569005576 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 694569005577 homodimer interface [polypeptide binding]; other site 694569005578 oligonucleotide binding site [chemical binding]; other site 694569005579 glutaredoxin 2; Provisional; Region: PRK10387 694569005580 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 694569005581 C-terminal domain interface [polypeptide binding]; other site 694569005582 GSH binding site (G-site) [chemical binding]; other site 694569005583 catalytic residues [active] 694569005584 putative dimer interface [polypeptide binding]; other site 694569005585 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 694569005586 N-terminal domain interface [polypeptide binding]; other site 694569005587 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 694569005588 NAD-dependent deacetylase; Provisional; Region: PRK00481 694569005589 NAD+ binding site [chemical binding]; other site 694569005590 substrate binding site [chemical binding]; other site 694569005591 Zn binding site [ion binding]; other site 694569005592 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 694569005593 cystathionine beta-lyase; Provisional; Region: PRK08114 694569005594 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 694569005595 homodimer interface [polypeptide binding]; other site 694569005596 substrate-cofactor binding pocket; other site 694569005597 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569005598 catalytic residue [active] 694569005599 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 694569005600 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 694569005601 trimer interface [polypeptide binding]; other site 694569005602 eyelet of channel; other site 694569005603 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 694569005604 PemK-like protein; Region: PemK; cl00995 694569005605 chaperone protein DnaJ; Provisional; Region: PRK10767 694569005606 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 694569005607 HSP70 interaction site [polypeptide binding]; other site 694569005608 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 694569005609 substrate binding site [polypeptide binding]; other site 694569005610 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 694569005611 Zn binding sites [ion binding]; other site 694569005612 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 694569005613 substrate binding site [polypeptide binding]; other site 694569005614 dimer interface [polypeptide binding]; other site 694569005615 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 694569005616 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 694569005617 nucleotide binding site [chemical binding]; other site 694569005618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 694569005619 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 694569005620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 694569005621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 694569005622 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 694569005623 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 694569005624 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 694569005625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005626 dimer interface [polypeptide binding]; other site 694569005627 conserved gate region; other site 694569005628 putative PBP binding loops; other site 694569005629 ABC-ATPase subunit interface; other site 694569005630 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 694569005631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569005632 Walker A/P-loop; other site 694569005633 ATP binding site [chemical binding]; other site 694569005634 Q-loop/lid; other site 694569005635 ABC transporter signature motif; other site 694569005636 Walker B; other site 694569005637 D-loop; other site 694569005638 H-loop/switch region; other site 694569005639 molybdenum transport protein ModD; Provisional; Region: PRK06096 694569005640 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 694569005641 dimerization interface [polypeptide binding]; other site 694569005642 active site 694569005643 protease TldD; Provisional; Region: tldD; PRK10735 694569005644 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 694569005645 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 694569005646 MG2 domain; Region: A2M_N; pfam01835 694569005647 Alpha-2-macroglobulin family; Region: A2M; pfam00207 694569005648 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 694569005649 surface patch; other site 694569005650 thioester region; other site 694569005651 specificity defining residues; other site 694569005652 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 694569005653 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 694569005654 Transglycosylase; Region: Transgly; pfam00912 694569005655 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 694569005656 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 694569005657 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569005658 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569005659 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569005660 peptide chain release factor 2; Provisional; Region: PRK05589 694569005661 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 694569005662 active site 694569005663 P-loop; other site 694569005664 phosphorylation site [posttranslational modification] 694569005665 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 694569005666 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 694569005667 TPP-binding site [chemical binding]; other site 694569005668 dimer interface [polypeptide binding]; other site 694569005669 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 694569005670 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694569005671 PYR/PP interface [polypeptide binding]; other site 694569005672 dimer interface [polypeptide binding]; other site 694569005673 TPP binding site [chemical binding]; other site 694569005674 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694569005675 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 694569005676 HemK family putative methylases; Region: hemK_fam; TIGR00536 694569005677 hypothetical protein; Provisional; Region: PRK04946 694569005678 Smr domain; Region: Smr; pfam01713 694569005679 TIGR01666 family membrane protein; Region: YCCS 694569005680 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 694569005681 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 694569005682 Predicted membrane protein [Function unknown]; Region: COG3304 694569005683 Domain of unknown function (DUF307); Region: DUF307; pfam03733 694569005684 Domain of unknown function (DUF307); Region: DUF307; pfam03733 694569005685 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 694569005686 active site 694569005687 dimer interfaces [polypeptide binding]; other site 694569005688 catalytic residues [active] 694569005689 hypothetical protein; Provisional; Region: PRK03641 694569005690 hypothetical protein; Provisional; Region: PRK01904 694569005691 acylphosphatase; Provisional; Region: PRK14448 694569005692 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 694569005693 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569005694 ABC-ATPase subunit interface; other site 694569005695 dimer interface [polypeptide binding]; other site 694569005696 putative PBP binding regions; other site 694569005697 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 694569005698 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569005699 ABC-ATPase subunit interface; other site 694569005700 dimer interface [polypeptide binding]; other site 694569005701 putative PBP binding regions; other site 694569005702 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 694569005703 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 694569005704 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 694569005705 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 694569005706 metal binding site [ion binding]; metal-binding site 694569005707 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 694569005708 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 694569005709 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 694569005710 YccA-like proteins; Region: YccA_like; cd10433 694569005711 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 694569005712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 694569005713 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 694569005714 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 694569005715 ATP binding site [chemical binding]; other site 694569005716 putative Mg++ binding site [ion binding]; other site 694569005717 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 694569005718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 694569005719 nucleotide binding region [chemical binding]; other site 694569005720 ATP-binding site [chemical binding]; other site 694569005721 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 694569005722 DNA methylase; Region: N6_N4_Mtase; pfam01555 694569005723 DNA methylase; Region: N6_N4_Mtase; pfam01555 694569005724 Virulence protein [General function prediction only]; Region: COG3943 694569005725 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 694569005726 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 694569005727 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 694569005728 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 694569005729 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 694569005730 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 694569005731 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 694569005732 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 694569005733 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 694569005734 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 694569005735 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 694569005736 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 694569005737 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 694569005738 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 694569005739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005740 dimer interface [polypeptide binding]; other site 694569005741 conserved gate region; other site 694569005742 putative PBP binding loops; other site 694569005743 ABC-ATPase subunit interface; other site 694569005744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005745 dimer interface [polypeptide binding]; other site 694569005746 conserved gate region; other site 694569005747 putative PBP binding loops; other site 694569005748 ABC-ATPase subunit interface; other site 694569005749 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 694569005750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569005751 Walker A/P-loop; other site 694569005752 ATP binding site [chemical binding]; other site 694569005753 Q-loop/lid; other site 694569005754 ABC transporter signature motif; other site 694569005755 Walker B; other site 694569005756 D-loop; other site 694569005757 H-loop/switch region; other site 694569005758 biotin synthase; Region: bioB; TIGR00433 694569005759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 694569005760 FeS/SAM binding site; other site 694569005761 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 694569005762 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 694569005763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 694569005764 dimerization interface [polypeptide binding]; other site 694569005765 putative DNA binding site [nucleotide binding]; other site 694569005766 putative Zn2+ binding site [ion binding]; other site 694569005767 AsnC family; Region: AsnC_trans_reg; pfam01037 694569005768 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 694569005769 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 694569005770 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 694569005771 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 694569005772 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 694569005773 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 694569005774 recombination factor protein RarA; Reviewed; Region: PRK13342 694569005775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569005776 Walker A motif; other site 694569005777 ATP binding site [chemical binding]; other site 694569005778 Walker B motif; other site 694569005779 arginine finger; other site 694569005780 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 694569005781 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 694569005782 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 694569005783 seryl-tRNA synthetase; Provisional; Region: PRK05431 694569005784 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 694569005785 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 694569005786 dimer interface [polypeptide binding]; other site 694569005787 active site 694569005788 motif 1; other site 694569005789 motif 2; other site 694569005790 motif 3; other site 694569005791 cytidine deaminase; Provisional; Region: PRK09027 694569005792 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 694569005793 active site 694569005794 catalytic motif [active] 694569005795 Zn binding site [ion binding]; other site 694569005796 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 694569005797 active site 694569005798 catalytic motif [active] 694569005799 Zn binding site [ion binding]; other site 694569005800 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 694569005801 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 694569005802 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 694569005803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005804 dimer interface [polypeptide binding]; other site 694569005805 conserved gate region; other site 694569005806 ABC-ATPase subunit interface; other site 694569005807 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 694569005808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569005809 dimer interface [polypeptide binding]; other site 694569005810 conserved gate region; other site 694569005811 putative PBP binding loops; other site 694569005812 ABC-ATPase subunit interface; other site 694569005813 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 694569005814 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 694569005815 Walker A/P-loop; other site 694569005816 ATP binding site [chemical binding]; other site 694569005817 Q-loop/lid; other site 694569005818 ABC transporter signature motif; other site 694569005819 Walker B; other site 694569005820 D-loop; other site 694569005821 H-loop/switch region; other site 694569005822 TOBE domain; Region: TOBE_2; pfam08402 694569005823 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 694569005824 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 694569005825 metal binding site [ion binding]; metal-binding site 694569005826 dimer interface [polypeptide binding]; other site 694569005827 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 694569005828 mce related protein; Region: MCE; pfam02470 694569005829 mce related protein; Region: MCE; pfam02470 694569005830 mce related protein; Region: MCE; pfam02470 694569005831 mce related protein; Region: MCE; pfam02470 694569005832 mce related protein; Region: MCE; pfam02470 694569005833 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 694569005834 Paraquat-inducible protein A; Region: PqiA; pfam04403 694569005835 Paraquat-inducible protein A; Region: PqiA; pfam04403 694569005836 ProP expression regulator; Provisional; Region: PRK04950 694569005837 ProQ/FINO family; Region: ProQ; pfam04352 694569005838 carboxy-terminal protease; Provisional; Region: PRK11186 694569005839 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 694569005840 protein binding site [polypeptide binding]; other site 694569005841 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 694569005842 Active site serine [active] 694569005843 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 694569005844 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 694569005845 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 694569005846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 694569005847 Peptidase M15; Region: Peptidase_M15_3; cl01194 694569005848 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 694569005849 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 694569005850 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 694569005851 TPP-binding site [chemical binding]; other site 694569005852 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 694569005853 dimer interface [polypeptide binding]; other site 694569005854 PYR/PP interface [polypeptide binding]; other site 694569005855 TPP binding site [chemical binding]; other site 694569005856 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 694569005857 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 694569005858 E3 interaction surface; other site 694569005859 lipoyl attachment site [posttranslational modification]; other site 694569005860 e3 binding domain; Region: E3_binding; pfam02817 694569005861 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 694569005862 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 694569005863 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 694569005864 CoA-ligase; Region: Ligase_CoA; pfam00549 694569005865 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 694569005866 CoA binding domain; Region: CoA_binding; pfam02629 694569005867 CoA-ligase; Region: Ligase_CoA; pfam00549 694569005868 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 694569005869 molybdopterin cofactor binding site; other site 694569005870 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 694569005871 molybdopterin cofactor binding site; other site 694569005872 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 694569005873 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 694569005874 FIC domain binding interface [polypeptide binding]; other site 694569005875 Fic/DOC family; Region: Fic; pfam02661 694569005876 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 694569005877 nickel binding site [ion binding]; other site 694569005878 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 694569005879 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 694569005880 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694569005881 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694569005882 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 694569005883 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 694569005884 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 694569005885 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 694569005886 hydrogenase 4 subunit F; Validated; Region: PRK06458 694569005887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 694569005888 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 694569005889 hydrogenase 4 subunit D; Validated; Region: PRK06525 694569005890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 694569005891 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 694569005892 NADH dehydrogenase; Region: NADHdh; cl00469 694569005893 hydrogenase 4 subunit B; Validated; Region: PRK06521 694569005894 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 694569005895 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 694569005896 4Fe-4S binding domain; Region: Fer4; pfam00037 694569005897 Acylphosphatase; Region: Acylphosphatase; pfam00708 694569005898 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 694569005899 HypF finger; Region: zf-HYPF; pfam07503 694569005900 HypF finger; Region: zf-HYPF; pfam07503 694569005901 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 694569005902 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 694569005903 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 694569005904 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 694569005905 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 694569005906 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 694569005907 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 694569005908 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 694569005909 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 694569005910 molybdopterin cofactor binding site; other site 694569005911 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 694569005912 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 694569005913 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 694569005914 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 694569005915 DNA binding site [nucleotide binding] 694569005916 domain linker motif; other site 694569005917 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 694569005918 putative ligand binding site [chemical binding]; other site 694569005919 putative dimerization interface [polypeptide binding]; other site 694569005920 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 694569005921 Shikimate kinase; Region: SKI; pfam01202 694569005922 ATP-binding site [chemical binding]; other site 694569005923 Gluconate-6-phosphate binding site [chemical binding]; other site 694569005924 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 694569005925 fructuronate transporter; Provisional; Region: PRK10034; cl15264 694569005926 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 694569005927 Part of AAA domain; Region: AAA_19; pfam13245 694569005928 Family description; Region: UvrD_C_2; pfam13538 694569005929 DNA ligase; Provisional; Region: PRK09125 694569005930 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 694569005931 DNA binding site [nucleotide binding] 694569005932 active site 694569005933 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 694569005934 DNA binding site [nucleotide binding] 694569005935 Uncharacterized conserved protein [Function unknown]; Region: COG1434 694569005936 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 694569005937 putative active site [active] 694569005938 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 694569005939 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 694569005940 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 694569005941 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 694569005942 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 694569005943 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 694569005944 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 694569005945 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 694569005946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 694569005947 active site 694569005948 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 694569005949 lytic murein transglycosylase; Region: MltB_2; TIGR02283 694569005950 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 694569005951 N-acetyl-D-glucosamine binding site [chemical binding]; other site 694569005952 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 694569005953 putative catalytic site [active] 694569005954 putative phosphate binding site [ion binding]; other site 694569005955 active site 694569005956 metal binding site A [ion binding]; metal-binding site 694569005957 DNA binding site [nucleotide binding] 694569005958 putative AP binding site [nucleotide binding]; other site 694569005959 putative metal binding site B [ion binding]; other site 694569005960 Family of unknown function (DUF695); Region: DUF695; pfam05117 694569005961 TIGR01619 family protein; Region: hyp_HI0040 694569005962 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 694569005963 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 694569005964 NAD binding site [chemical binding]; other site 694569005965 substrate binding site [chemical binding]; other site 694569005966 homodimer interface [polypeptide binding]; other site 694569005967 active site 694569005968 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 694569005969 dimerization interface [polypeptide binding]; other site 694569005970 active site 694569005971 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 694569005972 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 694569005973 active site 694569005974 fructokinase; Reviewed; Region: PRK09557 694569005975 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 694569005976 nucleotide binding site [chemical binding]; other site 694569005977 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 694569005978 Phosphotransferase enzyme family; Region: APH; pfam01636 694569005979 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 694569005980 active site 694569005981 ATP binding site [chemical binding]; other site 694569005982 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 694569005983 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 694569005984 active site 694569005985 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 694569005986 catalytic triad [active] 694569005987 dimer interface [polypeptide binding]; other site 694569005988 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 694569005989 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694569005990 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 694569005991 Walker A/P-loop; other site 694569005992 ATP binding site [chemical binding]; other site 694569005993 Q-loop/lid; other site 694569005994 ABC transporter signature motif; other site 694569005995 Walker B; other site 694569005996 D-loop; other site 694569005997 H-loop/switch region; other site 694569005998 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 694569005999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 694569006000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569006001 Walker A/P-loop; other site 694569006002 ATP binding site [chemical binding]; other site 694569006003 Q-loop/lid; other site 694569006004 ABC transporter signature motif; other site 694569006005 Walker B; other site 694569006006 D-loop; other site 694569006007 H-loop/switch region; other site 694569006008 thioredoxin reductase; Provisional; Region: PRK10262 694569006009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 694569006010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 694569006011 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 694569006012 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 694569006013 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 694569006014 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 694569006015 ATP binding site [chemical binding]; other site 694569006016 substrate interface [chemical binding]; other site 694569006017 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 694569006018 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 694569006019 dimer interface [polypeptide binding]; other site 694569006020 putative functional site; other site 694569006021 putative MPT binding site; other site 694569006022 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 694569006023 homodecamer interface [polypeptide binding]; other site 694569006024 GTP cyclohydrolase I; Provisional; Region: PLN03044 694569006025 active site 694569006026 putative catalytic site residues [active] 694569006027 zinc binding site [ion binding]; other site 694569006028 GTP-CH-I/GFRP interaction surface; other site 694569006029 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 694569006030 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 694569006031 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 694569006032 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 694569006033 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 694569006034 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 694569006035 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 694569006036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569006037 non-specific DNA binding site [nucleotide binding]; other site 694569006038 sequence-specific DNA binding site [nucleotide binding]; other site 694569006039 salt bridge; other site 694569006040 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 694569006041 Lumazine binding domain; Region: Lum_binding; pfam00677 694569006042 Lumazine binding domain; Region: Lum_binding; pfam00677 694569006043 multidrug efflux protein; Reviewed; Region: PRK01766 694569006044 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 694569006045 cation binding site [ion binding]; other site 694569006046 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 694569006047 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694569006048 N-terminal plug; other site 694569006049 ligand-binding site [chemical binding]; other site 694569006050 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 694569006051 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 694569006052 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 694569006053 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 694569006054 putative deacylase active site [active] 694569006055 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901 694569006056 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 694569006057 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 694569006058 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 694569006059 active site 694569006060 HIGH motif; other site 694569006061 KMSK motif region; other site 694569006062 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 694569006063 tRNA binding surface [nucleotide binding]; other site 694569006064 anticodon binding site; other site 694569006065 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 694569006066 putative metal binding site [ion binding]; other site 694569006067 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 694569006068 peptide chain release factor 1; Validated; Region: prfA; PRK00591 694569006069 This domain is found in peptide chain release factors; Region: PCRF; smart00937 694569006070 RF-1 domain; Region: RF-1; pfam00472 694569006071 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 694569006072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569006073 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 694569006074 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 694569006075 NlpC/P60 family; Region: NLPC_P60; pfam00877 694569006076 YcgL domain; Region: YcgL; cl01189 694569006077 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 694569006078 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 694569006079 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 694569006080 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694569006081 catalytic core [active] 694569006082 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 694569006083 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 694569006084 active site 694569006085 substrate binding site [chemical binding]; other site 694569006086 metal binding site [ion binding]; metal-binding site 694569006087 dihydropteroate synthase; Region: DHPS; TIGR01496 694569006088 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 694569006089 substrate binding pocket [chemical binding]; other site 694569006090 dimer interface [polypeptide binding]; other site 694569006091 inhibitor binding site; inhibition site 694569006092 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 694569006093 active site 694569006094 DNA polymerase IV; Validated; Region: PRK02406 694569006095 DNA binding site [nucleotide binding] 694569006096 HTH-like domain; Region: HTH_21; pfam13276 694569006097 Integrase core domain; Region: rve; pfam00665 694569006098 Integrase core domain; Region: rve_2; pfam13333 694569006099 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 694569006100 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 694569006101 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 694569006102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 694569006103 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 694569006104 active site 694569006105 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 694569006106 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 694569006107 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 694569006108 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 694569006109 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 694569006110 Walker A/P-loop; other site 694569006111 ATP binding site [chemical binding]; other site 694569006112 Q-loop/lid; other site 694569006113 ABC transporter signature motif; other site 694569006114 Walker B; other site 694569006115 D-loop; other site 694569006116 H-loop/switch region; other site 694569006117 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 694569006118 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 694569006119 Walker A/P-loop; other site 694569006120 ATP binding site [chemical binding]; other site 694569006121 Q-loop/lid; other site 694569006122 ABC transporter signature motif; other site 694569006123 Walker B; other site 694569006124 D-loop; other site 694569006125 H-loop/switch region; other site 694569006126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 694569006127 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 694569006128 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 694569006129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569006130 dimer interface [polypeptide binding]; other site 694569006131 conserved gate region; other site 694569006132 putative PBP binding loops; other site 694569006133 ABC-ATPase subunit interface; other site 694569006134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 694569006135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569006136 dimer interface [polypeptide binding]; other site 694569006137 conserved gate region; other site 694569006138 putative PBP binding loops; other site 694569006139 ABC-ATPase subunit interface; other site 694569006140 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 694569006141 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 694569006142 peptide binding site [polypeptide binding]; other site 694569006143 YcjX-like family, DUF463; Region: DUF463; cl01193 694569006144 hypothetical protein; Provisional; Region: PRK05415 694569006145 Domain of unknown function (DUF697); Region: DUF697; cl12064 694569006146 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 694569006147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 694569006148 Walker A motif; other site 694569006149 ATP binding site [chemical binding]; other site 694569006150 Walker B motif; other site 694569006151 arginine finger; other site 694569006152 GTPase HflX; Provisional; Region: PRK11058 694569006153 bacterial Hfq-like; Region: Hfq; cd01716 694569006154 hexamer interface [polypeptide binding]; other site 694569006155 Sm1 motif; other site 694569006156 RNA binding site [nucleotide binding]; other site 694569006157 Sm2 motif; other site 694569006158 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 694569006159 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 694569006160 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 694569006161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 694569006162 ATP binding site [chemical binding]; other site 694569006163 Mg2+ binding site [ion binding]; other site 694569006164 G-X-G motif; other site 694569006165 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 694569006166 ATP binding site [chemical binding]; other site 694569006167 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 694569006168 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 694569006169 active site 694569006170 metal binding site [ion binding]; metal-binding site 694569006171 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694569006172 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694569006173 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 694569006174 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 694569006175 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 694569006176 Predicted membrane protein [Function unknown]; Region: COG2246 694569006177 GtrA-like protein; Region: GtrA; pfam04138 694569006178 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 694569006179 Ligand binding site; other site 694569006180 Putative Catalytic site; other site 694569006181 DXD motif; other site 694569006182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 694569006183 S-adenosylmethionine binding site [chemical binding]; other site 694569006184 spermidine synthase; Provisional; Region: PRK03612 694569006185 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 694569006186 Sulfatase; Region: Sulfatase; pfam00884 694569006187 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 694569006188 active site 694569006189 catalytic residues [active] 694569006190 DNA binding site [nucleotide binding] 694569006191 Int/Topo IB signature motif; other site 694569006192 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 694569006193 Putative helicase; Region: TraI_2; pfam07514 694569006194 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 694569006195 PemK-like protein; Region: PemK; cl00995 694569006196 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 694569006197 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 694569006198 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 694569006199 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 694569006200 putative catalytic site [active] 694569006201 CdtC interface [polypeptide binding]; other site 694569006202 heterotrimer interface [polypeptide binding]; other site 694569006203 CdtA interface [polypeptide binding]; other site 694569006204 putative metal binding site [ion binding]; other site 694569006205 putative phosphate binding site [ion binding]; other site 694569006206 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 694569006207 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 694569006208 Abi-like protein; Region: Abi_2; pfam07751 694569006209 integrative conjugative element protein, RAQPRD family; Region: ICE_RAQPRD; TIGR01690 694569006210 Plasmid protein of unknown function (Plasmid_RAQPRD); Region: Plasmid_RAQPRD; pfam09686 694569006211 Protein of unknown function (DUF2976); Region: DUF2976; pfam11190 694569006212 Protein of unknown function (DUF3487); Region: DUF3487; pfam11990 694569006213 Protein of unknown function (DUF2895); Region: DUF2895; pfam11444 694569006214 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 694569006215 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 694569006216 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 694569006217 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 694569006218 catalytic site [active] 694569006219 putative active site [active] 694569006220 putative substrate binding site [chemical binding]; other site 694569006221 dimer interface [polypeptide binding]; other site 694569006222 GTPase RsgA; Reviewed; Region: PRK12288 694569006223 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 694569006224 RNA binding site [nucleotide binding]; other site 694569006225 homodimer interface [polypeptide binding]; other site 694569006226 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 694569006227 GTPase/Zn-binding domain interface [polypeptide binding]; other site 694569006228 GTP/Mg2+ binding site [chemical binding]; other site 694569006229 G4 box; other site 694569006230 G5 box; other site 694569006231 G1 box; other site 694569006232 Switch I region; other site 694569006233 G2 box; other site 694569006234 G3 box; other site 694569006235 Switch II region; other site 694569006236 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 694569006237 dimerization domain swap beta strand [polypeptide binding]; other site 694569006238 regulatory protein interface [polypeptide binding]; other site 694569006239 active site 694569006240 regulatory phosphorylation site [posttranslational modification]; other site 694569006241 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 694569006242 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 694569006243 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 694569006244 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 694569006245 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 694569006246 HPr interaction site; other site 694569006247 glycerol kinase (GK) interaction site [polypeptide binding]; other site 694569006248 active site 694569006249 phosphorylation site [posttranslational modification] 694569006250 oligopeptidase A; Provisional; Region: PRK10911 694569006251 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 694569006252 active site 694569006253 Zn binding site [ion binding]; other site 694569006254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 694569006255 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 694569006256 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 694569006257 peptide binding site [polypeptide binding]; other site 694569006258 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 694569006259 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569006260 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569006261 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 694569006262 putative active site [active] 694569006263 catalytic site [active] 694569006264 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 694569006265 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 694569006266 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 694569006267 hypothetical protein; Provisional; Region: PRK07101 694569006268 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 694569006269 substrate-cofactor binding pocket; other site 694569006270 homodimer interface [polypeptide binding]; other site 694569006271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 694569006272 catalytic residue [active] 694569006273 para-aminobenzoate synthase component I; Validated; Region: PRK07093 694569006274 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 694569006275 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 694569006276 Glutamine amidotransferase class-I; Region: GATase; pfam00117 694569006277 glutamine binding [chemical binding]; other site 694569006278 catalytic triad [active] 694569006279 glycerate dehydrogenase; Provisional; Region: PRK06932 694569006280 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 694569006281 putative ligand binding site [chemical binding]; other site 694569006282 putative NAD binding site [chemical binding]; other site 694569006283 catalytic site [active] 694569006284 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 694569006285 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 694569006286 Phosphotransferase enzyme family; Region: APH; pfam01636 694569006287 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 694569006288 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 694569006289 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 694569006290 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 694569006291 active site 694569006292 dimer interface [polypeptide binding]; other site 694569006293 motif 1; other site 694569006294 motif 2; other site 694569006295 motif 3; other site 694569006296 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 694569006297 anticodon binding site; other site 694569006298 HTH-like domain; Region: HTH_21; pfam13276 694569006299 Integrase core domain; Region: rve; pfam00665 694569006300 Integrase core domain; Region: rve_2; pfam13333 694569006301 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 694569006302 ferredoxin-NADP reductase; Provisional; Region: PRK10926 694569006303 FAD binding pocket [chemical binding]; other site 694569006304 FAD binding motif [chemical binding]; other site 694569006305 phosphate binding motif [ion binding]; other site 694569006306 beta-alpha-beta structure motif; other site 694569006307 NAD binding pocket [chemical binding]; other site 694569006308 translation initiation factor IF-3; Region: infC; TIGR00168 694569006309 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 694569006310 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 694569006311 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 694569006312 23S rRNA binding site [nucleotide binding]; other site 694569006313 L21 binding site [polypeptide binding]; other site 694569006314 L13 binding site [polypeptide binding]; other site 694569006315 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 694569006316 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12858 694569006317 D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit; Region: agaZ_gatZ; TIGR02810 694569006318 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 694569006319 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 694569006320 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 694569006321 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 694569006322 putative NAD(P) binding site [chemical binding]; other site 694569006323 catalytic Zn binding site [ion binding]; other site 694569006324 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 694569006325 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 694569006326 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 694569006327 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 694569006328 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 694569006329 TPP-binding site; other site 694569006330 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 694569006331 PYR/PP interface [polypeptide binding]; other site 694569006332 dimer interface [polypeptide binding]; other site 694569006333 TPP binding site [chemical binding]; other site 694569006334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 694569006335 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 694569006336 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 694569006337 substrate binding pocket [chemical binding]; other site 694569006338 chain length determination region; other site 694569006339 substrate-Mg2+ binding site; other site 694569006340 catalytic residues [active] 694569006341 aspartate-rich region 1; other site 694569006342 active site lid residues [active] 694569006343 aspartate-rich region 2; other site 694569006344 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 694569006345 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 694569006346 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 694569006347 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 694569006348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 694569006349 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 694569006350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 694569006351 catalytic core [active] 694569006352 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 694569006353 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 694569006354 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 694569006355 putative active site [active] 694569006356 catalytic site [active] 694569006357 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 694569006358 putative active site [active] 694569006359 catalytic site [active] 694569006360 Predicted membrane protein [Function unknown]; Region: COG2431 694569006361 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 694569006362 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 694569006363 active site 694569006364 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 694569006365 EamA-like transporter family; Region: EamA; pfam00892 694569006366 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 694569006367 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 694569006368 PhnA protein; Region: PhnA; pfam03831 694569006369 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 694569006370 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 694569006371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694569006372 Walker A/P-loop; other site 694569006373 ATP binding site [chemical binding]; other site 694569006374 Q-loop/lid; other site 694569006375 ABC transporter signature motif; other site 694569006376 Walker B; other site 694569006377 D-loop; other site 694569006378 H-loop/switch region; other site 694569006379 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694569006380 FtsX-like permease family; Region: FtsX; pfam02687 694569006381 macrolide transporter subunit MacA; Provisional; Region: PRK11578 694569006382 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 694569006383 HlyD family secretion protein; Region: HlyD_3; pfam13437 694569006384 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 694569006385 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 694569006386 active site 694569006387 HIGH motif; other site 694569006388 nucleotide binding site [chemical binding]; other site 694569006389 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 694569006390 KMSKS motif; other site 694569006391 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 694569006392 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 694569006393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 694569006394 non-specific DNA binding site [nucleotide binding]; other site 694569006395 salt bridge; other site 694569006396 sequence-specific DNA binding site [nucleotide binding]; other site 694569006397 hypothetical protein; Provisional; Region: PRK05170 694569006398 Integrase core domain; Region: rve_3; pfam13683 694569006399 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 694569006400 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 694569006401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694569006402 FtsX-like permease family; Region: FtsX; pfam02687 694569006403 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 694569006404 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 694569006405 Walker A/P-loop; other site 694569006406 ATP binding site [chemical binding]; other site 694569006407 Q-loop/lid; other site 694569006408 ABC transporter signature motif; other site 694569006409 Walker B; other site 694569006410 D-loop; other site 694569006411 H-loop/switch region; other site 694569006412 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 694569006413 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 694569006414 FtsX-like permease family; Region: FtsX; pfam02687 694569006415 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 694569006416 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 694569006417 replicative DNA helicase; Validated; Region: PRK06904 694569006418 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 694569006419 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 694569006420 Walker A motif; other site 694569006421 ATP binding site [chemical binding]; other site 694569006422 Walker B motif; other site 694569006423 DNA binding loops [nucleotide binding] 694569006424 alanine racemase; Reviewed; Region: alr; PRK00053 694569006425 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 694569006426 active site 694569006427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 694569006428 substrate binding site [chemical binding]; other site 694569006429 catalytic residues [active] 694569006430 dimer interface [polypeptide binding]; other site 694569006431 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 694569006432 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 694569006433 active site 694569006434 dimer interface [polypeptide binding]; other site 694569006435 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 694569006436 dimer interface [polypeptide binding]; other site 694569006437 active site 694569006438 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 694569006439 homopentamer interface [polypeptide binding]; other site 694569006440 active site 694569006441 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 694569006442 putative RNA binding site [nucleotide binding]; other site 694569006443 thiamine monophosphate kinase; Provisional; Region: PRK05731 694569006444 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 694569006445 ATP binding site [chemical binding]; other site 694569006446 dimerization interface [polypeptide binding]; other site 694569006447 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 694569006448 tetramer interfaces [polypeptide binding]; other site 694569006449 binuclear metal-binding site [ion binding]; other site 694569006450 LysE type translocator; Region: LysE; cl00565 694569006451 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 694569006452 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 694569006453 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 694569006454 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 694569006455 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 694569006456 catalytic loop [active] 694569006457 iron binding site [ion binding]; other site 694569006458 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 694569006459 dimer interface [polypeptide binding]; other site 694569006460 putative radical transfer pathway; other site 694569006461 diiron center [ion binding]; other site 694569006462 tyrosyl radical; other site 694569006463 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 694569006464 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 694569006465 metal binding triad [ion binding]; metal-binding site 694569006466 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 694569006467 ATP cone domain; Region: ATP-cone; pfam03477 694569006468 Class I ribonucleotide reductase; Region: RNR_I; cd01679 694569006469 active site 694569006470 dimer interface [polypeptide binding]; other site 694569006471 catalytic residues [active] 694569006472 effector binding site; other site 694569006473 R2 peptide binding site; other site 694569006474 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 694569006475 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 694569006476 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 694569006477 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 694569006478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569006479 dimer interface [polypeptide binding]; other site 694569006480 conserved gate region; other site 694569006481 putative PBP binding loops; other site 694569006482 ABC-ATPase subunit interface; other site 694569006483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569006484 dimer interface [polypeptide binding]; other site 694569006485 conserved gate region; other site 694569006486 putative PBP binding loops; other site 694569006487 ABC-ATPase subunit interface; other site 694569006488 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 694569006489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 694569006490 Walker A/P-loop; other site 694569006491 ATP binding site [chemical binding]; other site 694569006492 Q-loop/lid; other site 694569006493 ABC transporter signature motif; other site 694569006494 Walker B; other site 694569006495 D-loop; other site 694569006496 H-loop/switch region; other site 694569006497 TOBE domain; Region: TOBE_2; pfam08402 694569006498 alpha-amylase; Reviewed; Region: malS; PRK09505 694569006499 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 694569006500 active site 694569006501 catalytic site [active] 694569006502 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 694569006503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569006504 dimer interface [polypeptide binding]; other site 694569006505 conserved gate region; other site 694569006506 putative PBP binding loops; other site 694569006507 ABC-ATPase subunit interface; other site 694569006508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 694569006509 dimer interface [polypeptide binding]; other site 694569006510 conserved gate region; other site 694569006511 putative PBP binding loops; other site 694569006512 ABC-ATPase subunit interface; other site 694569006513 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 694569006514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 694569006515 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 694569006516 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 694569006517 Walker A/P-loop; other site 694569006518 ATP binding site [chemical binding]; other site 694569006519 Q-loop/lid; other site 694569006520 ABC transporter signature motif; other site 694569006521 Walker B; other site 694569006522 D-loop; other site 694569006523 H-loop/switch region; other site 694569006524 TOBE domain; Region: TOBE_2; pfam08402 694569006525 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 694569006526 trimer interface; other site 694569006527 sugar binding site [chemical binding]; other site 694569006528 maltose regulon periplasmic protein; Provisional; Region: PRK10564 694569006529 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 694569006530 active site 694569006531 phosphate binding residues; other site 694569006532 catalytic residues [active] 694569006533 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 694569006534 DEAD_2; Region: DEAD_2; pfam06733 694569006535 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 694569006536 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 694569006537 Glycoprotease family; Region: Peptidase_M22; pfam00814 694569006538 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 694569006539 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 694569006540 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 694569006541 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 694569006542 acyl-activating enzyme (AAE) consensus motif; other site 694569006543 putative AMP binding site [chemical binding]; other site 694569006544 putative active site [active] 694569006545 putative CoA binding site [chemical binding]; other site 694569006546 ribonuclease D; Provisional; Region: PRK10829 694569006547 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 694569006548 catalytic site [active] 694569006549 putative active site [active] 694569006550 putative substrate binding site [chemical binding]; other site 694569006551 HRDC domain; Region: HRDC; pfam00570 694569006552 Haem-binding domain; Region: Haem_bd; pfam14376 694569006553 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 694569006554 Protein of unknown function, DUF417; Region: DUF417; cl01162 694569006555 Domain of unknown function DUF302; Region: DUF302; pfam03625 694569006556 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 694569006557 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 694569006558 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 694569006559 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 694569006560 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 694569006561 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 694569006562 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 694569006563 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 694569006564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 694569006565 putative acyl-acceptor binding pocket; other site 694569006566 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 694569006567 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 694569006568 putative ribose interaction site [chemical binding]; other site 694569006569 putative ADP binding site [chemical binding]; other site 694569006570 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 694569006571 active site 694569006572 nucleotide binding site [chemical binding]; other site 694569006573 HIGH motif; other site 694569006574 KMSKS motif; other site 694569006575 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 694569006576 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 694569006577 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 694569006578 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 694569006579 catalytic residue [active] 694569006580 Staphylococcal nuclease homologues; Region: SNc; smart00318 694569006581 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 694569006582 Catalytic site; other site 694569006583 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 694569006584 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 694569006585 Ligand Binding Site [chemical binding]; other site 694569006586 DoxX; Region: DoxX; pfam07681 694569006587 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 694569006588 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694569006589 N-terminal plug; other site 694569006590 ligand-binding site [chemical binding]; other site 694569006591 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 694569006592 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 694569006593 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 694569006594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569006595 ABC-ATPase subunit interface; other site 694569006596 dimer interface [polypeptide binding]; other site 694569006597 putative PBP binding regions; other site 694569006598 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 694569006599 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 694569006600 outer membrane receptor FepA; Provisional; Region: PRK13524 694569006601 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 694569006602 N-terminal plug; other site 694569006603 ligand-binding site [chemical binding]; other site 694569006604 molybdenum-pterin binding domain; Region: Mop; TIGR00638 694569006605 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 694569006606 putative ligand binding residues [chemical binding]; other site 694569006607 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 694569006608 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 694569006609 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 694569006610 Walker A/P-loop; other site 694569006611 ATP binding site [chemical binding]; other site 694569006612 Q-loop/lid; other site 694569006613 ABC transporter signature motif; other site 694569006614 Walker B; other site 694569006615 D-loop; other site 694569006616 H-loop/switch region; other site 694569006617 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 694569006618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 694569006619 ABC-ATPase subunit interface; other site 694569006620 dimer interface [polypeptide binding]; other site 694569006621 putative PBP binding regions; other site 694569006622 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 694569006623 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 694569006624 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 694569006625 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 694569006626 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 694569006627 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612