-- dump date 20140618_193445 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1245469000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1245469000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1245469000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469000004 Walker A motif; other site 1245469000005 ATP binding site [chemical binding]; other site 1245469000006 Walker B motif; other site 1245469000007 arginine finger; other site 1245469000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1245469000009 DnaA box-binding interface [nucleotide binding]; other site 1245469000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1245469000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1245469000012 putative DNA binding surface [nucleotide binding]; other site 1245469000013 dimer interface [polypeptide binding]; other site 1245469000014 beta-clamp/clamp loader binding surface; other site 1245469000015 beta-clamp/translesion DNA polymerase binding surface; other site 1245469000016 recombination protein F; Reviewed; Region: recF; PRK00064 1245469000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469000018 Walker A/P-loop; other site 1245469000019 ATP binding site [chemical binding]; other site 1245469000020 Q-loop/lid; other site 1245469000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469000022 ABC transporter signature motif; other site 1245469000023 Walker B; other site 1245469000024 D-loop; other site 1245469000025 H-loop/switch region; other site 1245469000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1245469000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469000028 Mg2+ binding site [ion binding]; other site 1245469000029 G-X-G motif; other site 1245469000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1245469000031 anchoring element; other site 1245469000032 dimer interface [polypeptide binding]; other site 1245469000033 ATP binding site [chemical binding]; other site 1245469000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1245469000035 active site 1245469000036 putative metal-binding site [ion binding]; other site 1245469000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1245469000038 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1245469000039 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1245469000040 oligomeric interface; other site 1245469000041 putative active site [active] 1245469000042 homodimer interface [polypeptide binding]; other site 1245469000043 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1245469000044 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1245469000045 hinge; other site 1245469000046 active site 1245469000047 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1245469000048 multidrug efflux protein NorA; Provisional; Region: PRK00187 1245469000049 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1245469000050 cation binding site [ion binding]; other site 1245469000051 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1245469000052 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1245469000053 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469000054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469000055 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469000056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469000057 Pirin-related protein [General function prediction only]; Region: COG1741 1245469000058 Pirin; Region: Pirin; pfam02678 1245469000059 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1245469000060 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1245469000061 ATP binding site [chemical binding]; other site 1245469000062 active site 1245469000063 substrate binding site [chemical binding]; other site 1245469000064 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1245469000065 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469000066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469000067 putative DNA binding site [nucleotide binding]; other site 1245469000068 putative Zn2+ binding site [ion binding]; other site 1245469000069 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469000070 LysR family transcriptional regulator; Provisional; Region: PRK14997 1245469000071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469000072 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469000073 putative effector binding pocket; other site 1245469000074 dimerization interface [polypeptide binding]; other site 1245469000075 short chain dehydrogenase; Provisional; Region: PRK06500 1245469000076 classical (c) SDRs; Region: SDR_c; cd05233 1245469000077 NAD(P) binding site [chemical binding]; other site 1245469000078 active site 1245469000079 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469000080 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469000081 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469000082 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1245469000083 putative FMN binding site [chemical binding]; other site 1245469000084 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1245469000085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469000086 motif II; other site 1245469000087 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1245469000088 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1245469000089 active site pocket [active] 1245469000090 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1245469000091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469000092 active site 1245469000093 metal binding site [ion binding]; metal-binding site 1245469000094 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469000095 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 1245469000096 putative C-terminal domain interface [polypeptide binding]; other site 1245469000097 putative GSH binding site (G-site) [chemical binding]; other site 1245469000098 putative dimer interface [polypeptide binding]; other site 1245469000099 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469000100 N-terminal domain interface [polypeptide binding]; other site 1245469000101 dimer interface [polypeptide binding]; other site 1245469000102 substrate binding pocket (H-site) [chemical binding]; other site 1245469000103 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1245469000104 succinic semialdehyde dehydrogenase; Region: PLN02278 1245469000105 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1245469000106 tetramerization interface [polypeptide binding]; other site 1245469000107 NAD(P) binding site [chemical binding]; other site 1245469000108 catalytic residues [active] 1245469000109 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469000110 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469000111 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 1245469000112 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1245469000113 substrate binding site [chemical binding]; other site 1245469000114 ATP binding site [chemical binding]; other site 1245469000115 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1245469000116 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1245469000117 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1245469000118 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1245469000119 active site 1245469000120 HIGH motif; other site 1245469000121 dimer interface [polypeptide binding]; other site 1245469000122 KMSKS motif; other site 1245469000123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1245469000124 Ligand Binding Site [chemical binding]; other site 1245469000125 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1245469000126 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1245469000127 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469000128 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1245469000129 Glycoprotease family; Region: Peptidase_M22; pfam00814 1245469000130 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1245469000131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469000132 Coenzyme A binding pocket [chemical binding]; other site 1245469000133 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1245469000134 metal binding site 2 [ion binding]; metal-binding site 1245469000135 putative DNA binding helix; other site 1245469000136 metal binding site 1 [ion binding]; metal-binding site 1245469000137 dimer interface [polypeptide binding]; other site 1245469000138 structural Zn2+ binding site [ion binding]; other site 1245469000139 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1245469000140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469000141 motif II; other site 1245469000142 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1245469000143 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1245469000144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469000145 FeS/SAM binding site; other site 1245469000146 TRAM domain; Region: TRAM; cl01282 1245469000147 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1245469000148 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1245469000149 PhoH-like protein; Region: PhoH; pfam02562 1245469000150 metal-binding heat shock protein; Provisional; Region: PRK00016 1245469000151 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1245469000152 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1245469000153 Transporter associated domain; Region: CorC_HlyC; pfam03471 1245469000154 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1245469000155 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1245469000156 putative active site [active] 1245469000157 catalytic triad [active] 1245469000158 putative dimer interface [polypeptide binding]; other site 1245469000159 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469000160 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469000161 non-specific DNA binding site [nucleotide binding]; other site 1245469000162 salt bridge; other site 1245469000163 sequence-specific DNA binding site [nucleotide binding]; other site 1245469000164 hypothetical protein; Provisional; Region: PRK07338 1245469000165 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1245469000166 metal binding site [ion binding]; metal-binding site 1245469000167 dimer interface [polypeptide binding]; other site 1245469000168 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1245469000169 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469000170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 1245469000171 Sm and related proteins; Region: Sm_like; cl00259 1245469000172 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1245469000173 putative oligomer interface [polypeptide binding]; other site 1245469000174 putative RNA binding site [nucleotide binding]; other site 1245469000175 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1245469000176 NusA N-terminal domain; Region: NusA_N; pfam08529 1245469000177 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1245469000178 RNA binding site [nucleotide binding]; other site 1245469000179 homodimer interface [polypeptide binding]; other site 1245469000180 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1245469000181 G-X-X-G motif; other site 1245469000182 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1245469000183 G-X-X-G motif; other site 1245469000184 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1245469000185 hypothetical protein; Provisional; Region: PRK09190 1245469000186 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1245469000187 putative RNA binding cleft [nucleotide binding]; other site 1245469000188 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1245469000189 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1245469000190 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1245469000191 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1245469000192 G1 box; other site 1245469000193 putative GEF interaction site [polypeptide binding]; other site 1245469000194 GTP/Mg2+ binding site [chemical binding]; other site 1245469000195 Switch I region; other site 1245469000196 G2 box; other site 1245469000197 G3 box; other site 1245469000198 Switch II region; other site 1245469000199 G4 box; other site 1245469000200 G5 box; other site 1245469000201 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1245469000202 Translation-initiation factor 2; Region: IF-2; pfam11987 1245469000203 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1245469000204 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1245469000205 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 1245469000206 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1245469000207 RNA binding site [nucleotide binding]; other site 1245469000208 active site 1245469000209 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1245469000210 16S/18S rRNA binding site [nucleotide binding]; other site 1245469000211 S13e-L30e interaction site [polypeptide binding]; other site 1245469000212 25S rRNA binding site [nucleotide binding]; other site 1245469000213 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1245469000214 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1245469000215 RNase E interface [polypeptide binding]; other site 1245469000216 trimer interface [polypeptide binding]; other site 1245469000217 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1245469000218 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1245469000219 RNase E interface [polypeptide binding]; other site 1245469000220 trimer interface [polypeptide binding]; other site 1245469000221 active site 1245469000222 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1245469000223 putative nucleic acid binding region [nucleotide binding]; other site 1245469000224 G-X-X-G motif; other site 1245469000225 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1245469000226 RNA binding site [nucleotide binding]; other site 1245469000227 domain interface; other site 1245469000228 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1245469000229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469000230 Coenzyme A binding pocket [chemical binding]; other site 1245469000231 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1245469000232 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06505 1245469000233 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1245469000234 NAD binding site [chemical binding]; other site 1245469000235 homotetramer interface [polypeptide binding]; other site 1245469000236 homodimer interface [polypeptide binding]; other site 1245469000237 substrate binding site [chemical binding]; other site 1245469000238 active site 1245469000239 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1245469000240 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1245469000241 dimer interface [polypeptide binding]; other site 1245469000242 active site 1245469000243 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 1245469000244 active site 2 [active] 1245469000245 active site 1 [active] 1245469000246 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1245469000247 metal binding site 2 [ion binding]; metal-binding site 1245469000248 putative DNA binding helix; other site 1245469000249 metal binding site 1 [ion binding]; metal-binding site 1245469000250 dimer interface [polypeptide binding]; other site 1245469000251 structural Zn2+ binding site [ion binding]; other site 1245469000252 Bacterial SH3 domain; Region: SH3_4; pfam06347 1245469000253 Bacterial SH3 domain; Region: SH3_4; pfam06347 1245469000254 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1245469000255 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1245469000256 dimerization interface [polypeptide binding]; other site 1245469000257 ligand binding site [chemical binding]; other site 1245469000258 NADP binding site [chemical binding]; other site 1245469000259 catalytic site [active] 1245469000260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1245469000261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469000262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469000263 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1245469000264 putative effector binding pocket; other site 1245469000265 putative dimerization interface [polypeptide binding]; other site 1245469000266 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469000267 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469000268 active site 1245469000269 catalytic tetrad [active] 1245469000270 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1245469000271 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1245469000272 ATP binding site [chemical binding]; other site 1245469000273 substrate interface [chemical binding]; other site 1245469000274 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469000275 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469000276 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469000277 ParA-like protein; Provisional; Region: PHA02518 1245469000278 P-loop; other site 1245469000279 Magnesium ion binding site [ion binding]; other site 1245469000280 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469000281 ParA-like protein; Provisional; Region: PHA02518 1245469000282 P-loop; other site 1245469000283 Magnesium ion binding site [ion binding]; other site 1245469000284 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469000285 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469000286 ligand binding site [chemical binding]; other site 1245469000287 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1245469000288 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1245469000289 DNA binding site [nucleotide binding] 1245469000290 catalytic residue [active] 1245469000291 H2TH interface [polypeptide binding]; other site 1245469000292 putative catalytic residues [active] 1245469000293 turnover-facilitating residue; other site 1245469000294 intercalation triad [nucleotide binding]; other site 1245469000295 8OG recognition residue [nucleotide binding]; other site 1245469000296 putative reading head residues; other site 1245469000297 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1245469000298 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1245469000299 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1245469000300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469000301 S-adenosylmethionine binding site [chemical binding]; other site 1245469000302 ABC1 family; Region: ABC1; cl17513 1245469000303 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1245469000304 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 1245469000305 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1245469000306 Flavoprotein; Region: Flavoprotein; pfam02441 1245469000307 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1245469000308 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1245469000309 trimer interface [polypeptide binding]; other site 1245469000310 active site 1245469000311 PAS fold; Region: PAS_7; pfam12860 1245469000312 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1245469000313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469000314 dimer interface [polypeptide binding]; other site 1245469000315 phosphorylation site [posttranslational modification] 1245469000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469000317 ATP binding site [chemical binding]; other site 1245469000318 Mg2+ binding site [ion binding]; other site 1245469000319 G-X-G motif; other site 1245469000320 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1245469000321 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1245469000322 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469000323 PilZ domain; Region: PilZ; pfam07238 1245469000324 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1245469000325 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1245469000326 Substrate binding site; other site 1245469000327 metal-binding site 1245469000328 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 1245469000329 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1245469000330 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 1245469000331 Part of AAA domain; Region: AAA_19; pfam13245 1245469000332 Family description; Region: UvrD_C_2; pfam13538 1245469000333 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1245469000334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1245469000335 catalytic residues [active] 1245469000336 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1245469000337 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1245469000338 active site 1245469000339 DNA binding site [nucleotide binding] 1245469000340 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1245469000341 DNA binding site [nucleotide binding] 1245469000342 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1245469000343 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469000344 active site 1245469000345 metal binding site [ion binding]; metal-binding site 1245469000346 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1245469000347 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1245469000348 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1245469000349 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1245469000350 substrate binding site [chemical binding]; other site 1245469000351 active site 1245469000352 catalytic residues [active] 1245469000353 heterodimer interface [polypeptide binding]; other site 1245469000354 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1245469000355 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1245469000356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469000357 catalytic residue [active] 1245469000358 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1245469000359 active site 1245469000360 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1245469000361 IHF dimer interface [polypeptide binding]; other site 1245469000362 IHF - DNA interface [nucleotide binding]; other site 1245469000363 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1245469000364 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1245469000365 tandem repeat interface [polypeptide binding]; other site 1245469000366 oligomer interface [polypeptide binding]; other site 1245469000367 active site residues [active] 1245469000368 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1245469000369 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1245469000370 RNA binding site [nucleotide binding]; other site 1245469000371 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1245469000372 RNA binding site [nucleotide binding]; other site 1245469000373 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1245469000374 RNA binding site [nucleotide binding]; other site 1245469000375 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1245469000376 RNA binding site [nucleotide binding]; other site 1245469000377 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1245469000378 RNA binding site [nucleotide binding]; other site 1245469000379 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1245469000380 RNA binding site [nucleotide binding]; other site 1245469000381 cytidylate kinase; Provisional; Region: cmk; PRK00023 1245469000382 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1245469000383 CMP-binding site; other site 1245469000384 The sites determining sugar specificity; other site 1245469000385 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1245469000386 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1245469000387 hinge; other site 1245469000388 active site 1245469000389 TIGR02300 family protein; Region: FYDLN_acid 1245469000390 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1245469000391 Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449 1245469000392 GIY-YIG motif/motif A; other site 1245469000393 putative active site [active] 1245469000394 putative metal binding site [ion binding]; other site 1245469000395 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469000396 MarR family; Region: MarR; pfam01047 1245469000397 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1245469000398 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469000399 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469000400 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469000401 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469000402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469000403 putative PBP binding loops; other site 1245469000404 dimer interface [polypeptide binding]; other site 1245469000405 ABC-ATPase subunit interface; other site 1245469000406 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469000407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469000408 dimer interface [polypeptide binding]; other site 1245469000409 conserved gate region; other site 1245469000410 putative PBP binding loops; other site 1245469000411 ABC-ATPase subunit interface; other site 1245469000412 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1245469000413 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1245469000414 Walker A/P-loop; other site 1245469000415 ATP binding site [chemical binding]; other site 1245469000416 Q-loop/lid; other site 1245469000417 ABC transporter signature motif; other site 1245469000418 Walker B; other site 1245469000419 D-loop; other site 1245469000420 H-loop/switch region; other site 1245469000421 TOBE domain; Region: TOBE_2; pfam08402 1245469000422 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1245469000423 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1245469000424 putative dimer interface [polypeptide binding]; other site 1245469000425 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 1245469000426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1245469000427 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1245469000428 active site 1245469000429 phosphorylation site [posttranslational modification] 1245469000430 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1245469000431 30S subunit binding site; other site 1245469000432 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 1245469000433 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1245469000434 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1245469000435 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1245469000436 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1245469000437 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1245469000438 Walker A/P-loop; other site 1245469000439 ATP binding site [chemical binding]; other site 1245469000440 Q-loop/lid; other site 1245469000441 ABC transporter signature motif; other site 1245469000442 Walker B; other site 1245469000443 D-loop; other site 1245469000444 H-loop/switch region; other site 1245469000445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 1245469000446 OstA-like protein; Region: OstA; pfam03968 1245469000447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 1245469000448 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1245469000449 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1245469000450 catalytic site [active] 1245469000451 putative active site [active] 1245469000452 putative substrate binding site [chemical binding]; other site 1245469000453 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1245469000454 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1245469000455 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469000456 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469000457 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1245469000458 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1245469000459 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1245469000460 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1245469000461 Low-spin heme binding site [chemical binding]; other site 1245469000462 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1245469000463 Putative water exit pathway; other site 1245469000464 Binuclear center (active site) [active] 1245469000465 Putative proton exit pathway; other site 1245469000466 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469000467 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1245469000468 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1245469000469 DctM-like transporters; Region: DctM; pfam06808 1245469000470 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469000471 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1245469000472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469000473 substrate binding pocket [chemical binding]; other site 1245469000474 membrane-bound complex binding site; other site 1245469000475 hinge residues; other site 1245469000476 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469000477 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469000478 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1245469000479 Trp docking motif [polypeptide binding]; other site 1245469000480 active site 1245469000481 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469000482 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469000483 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1245469000484 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1245469000485 putative NAD(P) binding site [chemical binding]; other site 1245469000486 active site 1245469000487 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1245469000488 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469000489 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1245469000490 GSH binding site (G-site) [chemical binding]; other site 1245469000491 C-terminal domain interface [polypeptide binding]; other site 1245469000492 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469000493 N-terminal domain interface [polypeptide binding]; other site 1245469000494 dimer interface [polypeptide binding]; other site 1245469000495 substrate binding pocket (H-site) [chemical binding]; other site 1245469000496 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1245469000497 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1245469000498 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469000499 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1245469000500 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1245469000501 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1245469000502 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1245469000503 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1245469000504 23S rRNA binding site [nucleotide binding]; other site 1245469000505 L21 binding site [polypeptide binding]; other site 1245469000506 L13 binding site [polypeptide binding]; other site 1245469000507 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1245469000508 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1245469000509 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1245469000510 dimer interface [polypeptide binding]; other site 1245469000511 motif 1; other site 1245469000512 active site 1245469000513 motif 2; other site 1245469000514 motif 3; other site 1245469000515 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1245469000516 putative active site [active] 1245469000517 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1245469000518 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1245469000519 putative tRNA-binding site [nucleotide binding]; other site 1245469000520 B3/4 domain; Region: B3_4; pfam03483 1245469000521 tRNA synthetase B5 domain; Region: B5; smart00874 1245469000522 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1245469000523 motif 1; other site 1245469000524 dimer interface [polypeptide binding]; other site 1245469000525 motif 3; other site 1245469000526 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1245469000527 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469000528 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1245469000529 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1245469000530 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1245469000531 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1245469000532 putative homodimer interface [polypeptide binding]; other site 1245469000533 putative homotetramer interface [polypeptide binding]; other site 1245469000534 putative allosteric switch controlling residues; other site 1245469000535 putative metal binding site [ion binding]; other site 1245469000536 putative homodimer-homodimer interface [polypeptide binding]; other site 1245469000537 YHS domain; Region: YHS; pfam04945 1245469000538 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1245469000539 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1245469000540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469000541 motif II; other site 1245469000542 CysZ-like protein; Reviewed; Region: PRK12768 1245469000543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469000544 putative substrate translocation pore; other site 1245469000545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469000546 Phospholipid methyltransferase; Region: PEMT; cl17370 1245469000547 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1245469000548 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1245469000549 malonyl-CoA binding site [chemical binding]; other site 1245469000550 dimer interface [polypeptide binding]; other site 1245469000551 active site 1245469000552 product binding site; other site 1245469000553 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1245469000554 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1245469000555 minor groove reading motif; other site 1245469000556 helix-hairpin-helix signature motif; other site 1245469000557 substrate binding pocket [chemical binding]; other site 1245469000558 active site 1245469000559 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1245469000560 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 1245469000561 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469000562 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1245469000563 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1245469000564 DNA binding site [nucleotide binding] 1245469000565 active site 1245469000566 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1245469000567 active site 1245469000568 catalytic triad [active] 1245469000569 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1245469000570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469000571 Walker A motif; other site 1245469000572 ATP binding site [chemical binding]; other site 1245469000573 Walker B motif; other site 1245469000574 arginine finger; other site 1245469000575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1245469000576 catalytic core [active] 1245469000577 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1245469000578 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1245469000579 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1245469000580 Uncharacterized conserved protein [Function unknown]; Region: COG5470 1245469000581 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1245469000582 active site 1245469000583 dimer interface [polypeptide binding]; other site 1245469000584 Predicted flavoprotein [General function prediction only]; Region: COG0431 1245469000585 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1245469000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469000587 S-adenosylmethionine binding site [chemical binding]; other site 1245469000588 chaperone protein DnaJ; Provisional; Region: PRK10767 1245469000589 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1245469000590 HSP70 interaction site [polypeptide binding]; other site 1245469000591 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1245469000592 substrate binding site [polypeptide binding]; other site 1245469000593 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1245469000594 Zn binding sites [ion binding]; other site 1245469000595 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1245469000596 dimer interface [polypeptide binding]; other site 1245469000597 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1245469000598 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1245469000599 nucleotide binding site [chemical binding]; other site 1245469000600 NEF interaction site [polypeptide binding]; other site 1245469000601 SBD interface [polypeptide binding]; other site 1245469000602 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1245469000603 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469000604 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1245469000605 catalytic triad [active] 1245469000606 metal binding site [ion binding]; metal-binding site 1245469000607 conserved cis-peptide bond; other site 1245469000608 heat shock protein GrpE; Provisional; Region: PRK14141 1245469000609 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1245469000610 dimer interface [polypeptide binding]; other site 1245469000611 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1245469000612 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1245469000613 ribonuclease PH; Reviewed; Region: rph; PRK00173 1245469000614 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1245469000615 hexamer interface [polypeptide binding]; other site 1245469000616 active site 1245469000617 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1245469000618 active site 1245469000619 dimerization interface [polypeptide binding]; other site 1245469000620 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1245469000621 HemN C-terminal domain; Region: HemN_C; pfam06969 1245469000622 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1245469000623 putative ligand binding site [chemical binding]; other site 1245469000624 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1245469000625 Predicted methyltransferases [General function prediction only]; Region: COG0313 1245469000626 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1245469000627 putative SAM binding site [chemical binding]; other site 1245469000628 putative homodimer interface [polypeptide binding]; other site 1245469000629 hypothetical protein; Reviewed; Region: PRK12497 1245469000630 glutathione synthetase; Provisional; Region: PRK05246 1245469000631 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1245469000632 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1245469000633 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1245469000634 putative catalytic site [active] 1245469000635 putative phosphate binding site [ion binding]; other site 1245469000636 active site 1245469000637 metal binding site A [ion binding]; metal-binding site 1245469000638 DNA binding site [nucleotide binding] 1245469000639 putative AP binding site [nucleotide binding]; other site 1245469000640 putative metal binding site B [ion binding]; other site 1245469000641 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469000642 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469000643 ligand binding site [chemical binding]; other site 1245469000644 flexible hinge region; other site 1245469000645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469000646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469000647 active site 1245469000648 phosphorylation site [posttranslational modification] 1245469000649 intermolecular recognition site; other site 1245469000650 dimerization interface [polypeptide binding]; other site 1245469000651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469000652 DNA binding site [nucleotide binding] 1245469000653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1245469000654 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1245469000655 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1245469000656 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469000657 catalytic residue [active] 1245469000658 HAMP domain; Region: HAMP; pfam00672 1245469000659 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469000660 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469000661 metal binding site [ion binding]; metal-binding site 1245469000662 active site 1245469000663 I-site; other site 1245469000664 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469000665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469000666 metal binding site [ion binding]; metal-binding site 1245469000667 active site 1245469000668 I-site; other site 1245469000669 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1245469000670 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1245469000671 HIGH motif; other site 1245469000672 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1245469000673 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469000674 active site 1245469000675 KMSKS motif; other site 1245469000676 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1245469000677 tRNA binding surface [nucleotide binding]; other site 1245469000678 Lipopolysaccharide-assembly; Region: LptE; pfam04390 1245469000679 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 1245469000680 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1245469000681 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1245469000682 ParB-like nuclease domain; Region: ParBc; pfam02195 1245469000683 KorB domain; Region: KorB; pfam08535 1245469000684 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1245469000685 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469000686 P-loop; other site 1245469000687 Magnesium ion binding site [ion binding]; other site 1245469000688 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469000689 Magnesium ion binding site [ion binding]; other site 1245469000690 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1245469000691 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1245469000692 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1245469000693 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1245469000694 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1245469000695 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1245469000696 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1245469000697 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1245469000698 G1 box; other site 1245469000699 GTP/Mg2+ binding site [chemical binding]; other site 1245469000700 Switch I region; other site 1245469000701 G2 box; other site 1245469000702 Switch II region; other site 1245469000703 G3 box; other site 1245469000704 G4 box; other site 1245469000705 G5 box; other site 1245469000706 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1245469000707 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1245469000708 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1245469000709 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1245469000710 RNA binding site [nucleotide binding]; other site 1245469000711 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1245469000712 multimer interface [polypeptide binding]; other site 1245469000713 Walker A motif; other site 1245469000714 ATP binding site [chemical binding]; other site 1245469000715 Walker B motif; other site 1245469000716 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 1245469000717 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1245469000718 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1245469000719 active site 1245469000720 dimer interface [polypeptide binding]; other site 1245469000721 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1245469000722 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1245469000723 CoA-binding site [chemical binding]; other site 1245469000724 ATP-binding [chemical binding]; other site 1245469000725 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1245469000726 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1245469000727 active site 1245469000728 catalytic site [active] 1245469000729 substrate binding site [chemical binding]; other site 1245469000730 preprotein translocase subunit SecB; Validated; Region: PRK05751 1245469000731 SecA binding site; other site 1245469000732 Preprotein binding site; other site 1245469000733 Tim44-like domain; Region: Tim44; pfam04280 1245469000734 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 1245469000735 MltA specific insert domain; Region: MltA; smart00925 1245469000736 3D domain; Region: 3D; pfam06725 1245469000737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1245469000738 Smr domain; Region: Smr; pfam01713 1245469000739 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1245469000740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469000741 Walker A motif; other site 1245469000742 ATP binding site [chemical binding]; other site 1245469000743 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1245469000744 Walker B motif; other site 1245469000745 arginine finger; other site 1245469000746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1245469000747 hypothetical protein; Provisional; Region: PRK00944 1245469000748 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1245469000749 active site 1245469000750 HslU subunit interaction site [polypeptide binding]; other site 1245469000751 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1245469000752 putative active site pocket [active] 1245469000753 4-fold oligomerization interface [polypeptide binding]; other site 1245469000754 metal binding residues [ion binding]; metal-binding site 1245469000755 3-fold/trimer interface [polypeptide binding]; other site 1245469000756 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1245469000757 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1245469000758 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1245469000759 putative active site [active] 1245469000760 oxyanion strand; other site 1245469000761 catalytic triad [active] 1245469000762 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1245469000763 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1245469000764 catalytic residues [active] 1245469000765 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1245469000766 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1245469000767 substrate binding site [chemical binding]; other site 1245469000768 glutamase interaction surface [polypeptide binding]; other site 1245469000769 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1245469000770 metal binding site [ion binding]; metal-binding site 1245469000771 pantothenate kinase; Provisional; Region: PRK05439 1245469000772 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1245469000773 ATP-binding site [chemical binding]; other site 1245469000774 CoA-binding site [chemical binding]; other site 1245469000775 Mg2+-binding site [ion binding]; other site 1245469000776 PAS domain S-box; Region: sensory_box; TIGR00229 1245469000777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469000778 putative active site [active] 1245469000779 heme pocket [chemical binding]; other site 1245469000780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469000781 dimer interface [polypeptide binding]; other site 1245469000782 phosphorylation site [posttranslational modification] 1245469000783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469000784 ATP binding site [chemical binding]; other site 1245469000785 Mg2+ binding site [ion binding]; other site 1245469000786 G-X-G motif; other site 1245469000787 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469000788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469000789 active site 1245469000790 phosphorylation site [posttranslational modification] 1245469000791 intermolecular recognition site; other site 1245469000792 dimerization interface [polypeptide binding]; other site 1245469000793 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1245469000794 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1245469000795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469000796 Walker A motif; other site 1245469000797 ATP binding site [chemical binding]; other site 1245469000798 Walker B motif; other site 1245469000799 arginine finger; other site 1245469000800 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1245469000801 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469000802 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1245469000803 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1245469000804 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1245469000805 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1245469000806 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1245469000807 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1245469000808 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 1245469000809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469000810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469000811 homodimer interface [polypeptide binding]; other site 1245469000812 catalytic residue [active] 1245469000813 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469000814 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1245469000815 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469000816 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469000817 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469000818 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469000819 Surface antigen; Region: Bac_surface_Ag; pfam01103 1245469000820 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1245469000821 classical (c) SDRs; Region: SDR_c; cd05233 1245469000822 NAD(P) binding site [chemical binding]; other site 1245469000823 active site 1245469000824 malonyl-CoA synthase; Validated; Region: PRK07514 1245469000825 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1245469000826 acyl-activating enzyme (AAE) consensus motif; other site 1245469000827 active site 1245469000828 AMP binding site [chemical binding]; other site 1245469000829 CoA binding site [chemical binding]; other site 1245469000830 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1245469000831 Iron-sulfur protein interface; other site 1245469000832 proximal quinone binding site [chemical binding]; other site 1245469000833 SdhD (CybS) interface [polypeptide binding]; other site 1245469000834 proximal heme binding site [chemical binding]; other site 1245469000835 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 1245469000836 putative SdhC subunit interface [polypeptide binding]; other site 1245469000837 putative proximal heme binding site [chemical binding]; other site 1245469000838 putative Iron-sulfur protein interface [polypeptide binding]; other site 1245469000839 putative proximal quinone binding site; other site 1245469000840 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 1245469000841 L-aspartate oxidase; Provisional; Region: PRK06175 1245469000842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1245469000843 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1245469000844 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1245469000845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469000846 dimer interface [polypeptide binding]; other site 1245469000847 phosphorylation site [posttranslational modification] 1245469000848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469000849 ATP binding site [chemical binding]; other site 1245469000850 Mg2+ binding site [ion binding]; other site 1245469000851 G-X-G motif; other site 1245469000852 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469000853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469000854 active site 1245469000855 phosphorylation site [posttranslational modification] 1245469000856 intermolecular recognition site; other site 1245469000857 dimerization interface [polypeptide binding]; other site 1245469000858 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1245469000859 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1245469000860 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1245469000861 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1245469000862 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1245469000863 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1245469000864 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469000865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469000866 ligand binding site [chemical binding]; other site 1245469000867 argininosuccinate synthase; Provisional; Region: PRK13820 1245469000868 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1245469000869 ANP binding site [chemical binding]; other site 1245469000870 Substrate Binding Site II [chemical binding]; other site 1245469000871 Substrate Binding Site I [chemical binding]; other site 1245469000872 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 1245469000873 active site 1245469000874 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1245469000875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469000876 FeS/SAM binding site; other site 1245469000877 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 1245469000878 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469000879 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1245469000880 NAD(P) binding site [chemical binding]; other site 1245469000881 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469000882 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1245469000883 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1245469000884 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 1245469000885 aromatic arch; other site 1245469000886 DCoH dimer interaction site [polypeptide binding]; other site 1245469000887 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1245469000888 DCoH tetramer interaction site [polypeptide binding]; other site 1245469000889 substrate binding site [chemical binding]; other site 1245469000890 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469000891 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1245469000892 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1245469000893 putative active site [active] 1245469000894 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469000895 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469000896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469000897 active site 1245469000898 phosphorylation site [posttranslational modification] 1245469000899 intermolecular recognition site; other site 1245469000900 dimerization interface [polypeptide binding]; other site 1245469000901 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469000902 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469000903 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469000904 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1245469000905 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1245469000906 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469000907 FeS/SAM binding site; other site 1245469000908 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1245469000909 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1245469000910 G1 box; other site 1245469000911 putative GEF interaction site [polypeptide binding]; other site 1245469000912 GTP/Mg2+ binding site [chemical binding]; other site 1245469000913 Switch I region; other site 1245469000914 G2 box; other site 1245469000915 G3 box; other site 1245469000916 Switch II region; other site 1245469000917 G4 box; other site 1245469000918 G5 box; other site 1245469000919 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1245469000920 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1245469000921 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469000922 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1245469000923 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1245469000924 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469000925 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1245469000926 putative dimerization interface [polypeptide binding]; other site 1245469000927 Predicted membrane protein [Function unknown]; Region: COG2855 1245469000928 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1245469000929 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 1245469000930 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469000931 putative NAD(P) binding site [chemical binding]; other site 1245469000932 active site 1245469000933 DoxX-like family; Region: DoxX_3; pfam13781 1245469000934 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 1245469000935 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469000936 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469000937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469000938 Coenzyme A binding pocket [chemical binding]; other site 1245469000939 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1245469000940 dimer interface [polypeptide binding]; other site 1245469000941 substrate binding site [chemical binding]; other site 1245469000942 metal binding sites [ion binding]; metal-binding site 1245469000943 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 1245469000944 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1245469000945 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1245469000946 homodimer interface [polypeptide binding]; other site 1245469000947 NADP binding site [chemical binding]; other site 1245469000948 substrate binding site [chemical binding]; other site 1245469000949 hypothetical protein; Validated; Region: PRK01310 1245469000950 YGGT family; Region: YGGT; pfam02325 1245469000951 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1245469000952 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1245469000953 catalytic triad [active] 1245469000954 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1245469000955 classical (c) SDRs; Region: SDR_c; cd05233 1245469000956 NAD(P) binding site [chemical binding]; other site 1245469000957 active site 1245469000958 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 1245469000959 putative metal binding site [ion binding]; other site 1245469000960 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469000961 cyclase homology domain; Region: CHD; cd07302 1245469000962 nucleotidyl binding site; other site 1245469000963 metal binding site [ion binding]; metal-binding site 1245469000964 dimer interface [polypeptide binding]; other site 1245469000965 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469000966 Cytochrome P450; Region: p450; cl12078 1245469000967 Lipase (class 2); Region: Lipase_2; pfam01674 1245469000968 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1245469000969 Transmembrane secretion effector; Region: MFS_3; pfam05977 1245469000970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469000971 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469000972 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469000973 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1245469000974 putative NAD(P) binding site [chemical binding]; other site 1245469000975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469000976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469000977 short chain dehydrogenase; Provisional; Region: PRK06179 1245469000978 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1245469000979 NADP binding site [chemical binding]; other site 1245469000980 active site 1245469000981 steroid binding site; other site 1245469000982 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 1245469000983 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1245469000984 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1245469000985 NodB motif; other site 1245469000986 active site 1245469000987 catalytic site [active] 1245469000988 metal binding site [ion binding]; metal-binding site 1245469000989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469000990 TPR motif; other site 1245469000991 binding surface 1245469000992 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469000993 GSCFA family; Region: GSCFA; pfam08885 1245469000994 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 1245469000995 HemY protein N-terminus; Region: HemY_N; pfam07219 1245469000996 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1245469000997 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1245469000998 active site 1245469000999 UGMP family protein; Validated; Region: PRK09604 1245469001000 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1245469001001 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1245469001002 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1245469001003 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1245469001004 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1245469001005 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469001006 substrate binding pocket [chemical binding]; other site 1245469001007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469001008 EVE domain; Region: EVE; pfam01878 1245469001009 Dodecin; Region: Dodecin; pfam07311 1245469001010 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 1245469001011 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1245469001012 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1245469001013 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1245469001014 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1245469001015 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1245469001016 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1245469001017 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1245469001018 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1245469001019 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1245469001020 active site 1245469001021 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1245469001022 catalytic triad [active] 1245469001023 dimer interface [polypeptide binding]; other site 1245469001024 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333 1245469001025 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469001026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469001027 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469001028 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1245469001029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469001030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469001031 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1245469001032 Iron permease FTR1 family; Region: FTR1; cl00475 1245469001033 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1245469001034 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1245469001035 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469001036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1245469001037 binding surface 1245469001038 TPR motif; other site 1245469001039 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1245469001040 putative hydrophobic ligand binding site [chemical binding]; other site 1245469001041 protein interface [polypeptide binding]; other site 1245469001042 gate; other site 1245469001043 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1245469001044 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 1245469001045 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 1245469001046 active site 1245469001047 indole acetimide hydrolase; Validated; Region: PRK07488 1245469001048 Amidase; Region: Amidase; cl11426 1245469001049 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1245469001050 Cytochrome c553 [Energy production and conversion]; Region: COG2863 1245469001051 Cytochrome c; Region: Cytochrom_C; cl11414 1245469001052 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1245469001053 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1245469001054 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1245469001055 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1245469001056 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1245469001057 putative NAD(P) binding site [chemical binding]; other site 1245469001058 active site 1245469001059 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1245469001060 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1245469001061 putative catalytic residue [active] 1245469001062 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1245469001063 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1245469001064 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 1245469001065 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469001066 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1245469001067 putative C-terminal domain interface [polypeptide binding]; other site 1245469001068 putative GSH binding site (G-site) [chemical binding]; other site 1245469001069 putative dimer interface [polypeptide binding]; other site 1245469001070 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 1245469001071 putative N-terminal domain interface [polypeptide binding]; other site 1245469001072 putative dimer interface [polypeptide binding]; other site 1245469001073 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469001074 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469001075 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469001076 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1245469001077 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1245469001078 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1245469001079 PAS fold; Region: PAS_7; pfam12860 1245469001080 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469001081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469001082 metal binding site [ion binding]; metal-binding site 1245469001083 active site 1245469001084 I-site; other site 1245469001085 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469001086 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1245469001087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469001088 substrate binding pocket [chemical binding]; other site 1245469001089 membrane-bound complex binding site; other site 1245469001090 hinge residues; other site 1245469001091 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1245469001092 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1245469001093 purine monophosphate binding site [chemical binding]; other site 1245469001094 dimer interface [polypeptide binding]; other site 1245469001095 putative catalytic residues [active] 1245469001096 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1245469001097 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1245469001098 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1245469001099 NusB family; Region: NusB; pfam01029 1245469001100 putative RNA binding site [nucleotide binding]; other site 1245469001101 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1245469001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469001103 S-adenosylmethionine binding site [chemical binding]; other site 1245469001104 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 1245469001105 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 1245469001106 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1245469001107 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1245469001108 CysD dimerization site [polypeptide binding]; other site 1245469001109 G1 box; other site 1245469001110 putative GEF interaction site [polypeptide binding]; other site 1245469001111 GTP/Mg2+ binding site [chemical binding]; other site 1245469001112 Switch I region; other site 1245469001113 G2 box; other site 1245469001114 G3 box; other site 1245469001115 Switch II region; other site 1245469001116 G4 box; other site 1245469001117 G5 box; other site 1245469001118 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1245469001119 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1245469001120 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1245469001121 ligand-binding site [chemical binding]; other site 1245469001122 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1245469001123 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1245469001124 Active Sites [active] 1245469001125 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469001126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469001127 dimer interface [polypeptide binding]; other site 1245469001128 putative CheW interface [polypeptide binding]; other site 1245469001129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469001130 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469001131 acetyl-CoA synthetase; Provisional; Region: PRK00174 1245469001132 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1245469001133 active site 1245469001134 CoA binding site [chemical binding]; other site 1245469001135 acyl-activating enzyme (AAE) consensus motif; other site 1245469001136 AMP binding site [chemical binding]; other site 1245469001137 acetate binding site [chemical binding]; other site 1245469001138 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1245469001139 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 1245469001140 active site 1245469001141 DNA binding site [nucleotide binding] 1245469001142 Int/Topo IB signature motif; other site 1245469001143 catalytic residues [active] 1245469001144 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1245469001145 Fasciclin domain; Region: Fasciclin; pfam02469 1245469001146 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1245469001147 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1245469001148 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1245469001149 Moco binding site; other site 1245469001150 metal coordination site [ion binding]; other site 1245469001151 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 1245469001152 tartrate dehydrogenase; Region: TTC; TIGR02089 1245469001153 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1245469001154 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469001155 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469001156 Walker A/P-loop; other site 1245469001157 ATP binding site [chemical binding]; other site 1245469001158 Q-loop/lid; other site 1245469001159 ABC transporter signature motif; other site 1245469001160 Walker B; other site 1245469001161 D-loop; other site 1245469001162 H-loop/switch region; other site 1245469001163 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469001164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469001165 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469001166 TM-ABC transporter signature motif; other site 1245469001167 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1245469001168 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1245469001169 putative ligand binding site [chemical binding]; other site 1245469001170 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1245469001171 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1245469001172 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1245469001173 active site clefts [active] 1245469001174 zinc binding site [ion binding]; other site 1245469001175 dimer interface [polypeptide binding]; other site 1245469001176 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1245469001177 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469001178 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1245469001179 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1245469001180 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1245469001181 substrate binding site [chemical binding]; other site 1245469001182 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1245469001183 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1245469001184 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1245469001185 substrate binding site [chemical binding]; other site 1245469001186 ligand binding site [chemical binding]; other site 1245469001187 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1245469001188 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1245469001189 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469001190 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469001191 RimM N-terminal domain; Region: RimM; pfam01782 1245469001192 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 1245469001193 PRC-barrel domain; Region: PRC; pfam05239 1245469001194 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1245469001195 signal recognition particle protein; Provisional; Region: PRK10867 1245469001196 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1245469001197 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1245469001198 P loop; other site 1245469001199 GTP binding site [chemical binding]; other site 1245469001200 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1245469001201 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1245469001202 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1245469001203 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1245469001204 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1245469001205 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1245469001206 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1245469001207 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1245469001208 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1245469001209 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1245469001210 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469001211 FeS/SAM binding site; other site 1245469001212 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1245469001213 active site 1245469001214 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1245469001215 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1245469001216 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1245469001217 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1245469001218 P loop; other site 1245469001219 GTP binding site [chemical binding]; other site 1245469001220 intracellular septation protein A; Reviewed; Region: PRK00259 1245469001221 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1245469001222 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1245469001223 catalytic residues [active] 1245469001224 central insert; other site 1245469001225 Heme exporter protein D (CcmD); Region: CcmD; pfam04995 1245469001226 heme exporter protein CcmC; Region: ccmC; TIGR01191 1245469001227 heme exporter protein CcmB; Region: ccmB; TIGR01190 1245469001228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469001229 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1245469001230 Walker A/P-loop; other site 1245469001231 ATP binding site [chemical binding]; other site 1245469001232 Q-loop/lid; other site 1245469001233 ABC transporter signature motif; other site 1245469001234 Walker B; other site 1245469001235 D-loop; other site 1245469001236 H-loop/switch region; other site 1245469001237 aconitate hydratase; Validated; Region: PRK09277 1245469001238 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1245469001239 substrate binding site [chemical binding]; other site 1245469001240 ligand binding site [chemical binding]; other site 1245469001241 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1245469001242 substrate binding site [chemical binding]; other site 1245469001243 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 1245469001244 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 1245469001245 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1245469001246 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1245469001247 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1245469001248 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1245469001249 FtsX-like permease family; Region: FtsX; pfam02687 1245469001250 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1245469001251 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469001252 Walker A/P-loop; other site 1245469001253 ATP binding site [chemical binding]; other site 1245469001254 Q-loop/lid; other site 1245469001255 ABC transporter signature motif; other site 1245469001256 Walker B; other site 1245469001257 D-loop; other site 1245469001258 H-loop/switch region; other site 1245469001259 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1245469001260 active site 1245469001261 oxyanion hole [active] 1245469001262 switch loop; other site 1245469001263 catalytic triad [active] 1245469001264 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1245469001265 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1245469001266 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1245469001267 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1245469001268 malate dehydrogenase; Reviewed; Region: PRK06223 1245469001269 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1245469001270 NAD(P) binding site [chemical binding]; other site 1245469001271 dimer interface [polypeptide binding]; other site 1245469001272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1245469001273 substrate binding site [chemical binding]; other site 1245469001274 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1245469001275 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1245469001276 CoA-ligase; Region: Ligase_CoA; pfam00549 1245469001277 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1245469001278 CoA binding domain; Region: CoA_binding; smart00881 1245469001279 CoA-ligase; Region: Ligase_CoA; pfam00549 1245469001280 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1245469001281 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1245469001282 TPP-binding site [chemical binding]; other site 1245469001283 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1245469001284 dimer interface [polypeptide binding]; other site 1245469001285 PYR/PP interface [polypeptide binding]; other site 1245469001286 TPP binding site [chemical binding]; other site 1245469001287 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1245469001288 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469001289 E3 interaction surface; other site 1245469001290 lipoyl attachment site [posttranslational modification]; other site 1245469001291 e3 binding domain; Region: E3_binding; pfam02817 1245469001292 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1245469001293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469001294 short chain dehydrogenase; Provisional; Region: PRK06123 1245469001295 NAD(P) binding site [chemical binding]; other site 1245469001296 active site 1245469001297 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1245469001298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469001299 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469001300 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1245469001301 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 1245469001302 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1245469001303 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1245469001304 active site 1245469001305 DNA binding site [nucleotide binding] 1245469001306 Int/Topo IB signature motif; other site 1245469001307 primosome assembly protein PriA; Validated; Region: PRK05580 1245469001308 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469001309 ATP binding site [chemical binding]; other site 1245469001310 putative Mg++ binding site [ion binding]; other site 1245469001311 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1245469001312 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1245469001313 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1245469001314 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1245469001315 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1245469001316 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1245469001317 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1245469001318 beta subunit interaction interface [polypeptide binding]; other site 1245469001319 Walker A motif; other site 1245469001320 ATP binding site [chemical binding]; other site 1245469001321 Walker B motif; other site 1245469001322 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1245469001323 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1245469001324 core domain interface [polypeptide binding]; other site 1245469001325 delta subunit interface [polypeptide binding]; other site 1245469001326 epsilon subunit interface [polypeptide binding]; other site 1245469001327 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1245469001328 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1245469001329 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1245469001330 alpha subunit interaction interface [polypeptide binding]; other site 1245469001331 Walker A motif; other site 1245469001332 ATP binding site [chemical binding]; other site 1245469001333 Walker B motif; other site 1245469001334 inhibitor binding site; inhibition site 1245469001335 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1245469001336 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13448 1245469001337 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1245469001338 gamma subunit interface [polypeptide binding]; other site 1245469001339 epsilon subunit interface [polypeptide binding]; other site 1245469001340 LBP interface [polypeptide binding]; other site 1245469001341 cyclase homology domain; Region: CHD; cd07302 1245469001342 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469001343 nucleotidyl binding site; other site 1245469001344 metal binding site [ion binding]; metal-binding site 1245469001345 dimer interface [polypeptide binding]; other site 1245469001346 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1245469001347 putative active site [active] 1245469001348 Ap4A binding site [chemical binding]; other site 1245469001349 nudix motif; other site 1245469001350 putative metal binding site [ion binding]; other site 1245469001351 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1245469001352 putative active site [active] 1245469001353 Ap4A binding site [chemical binding]; other site 1245469001354 nudix motif; other site 1245469001355 putative metal binding site [ion binding]; other site 1245469001356 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1245469001357 putative active site [active] 1245469001358 NodB motif; other site 1245469001359 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1245469001360 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1245469001361 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1245469001362 protein binding site [polypeptide binding]; other site 1245469001363 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1245469001364 Catalytic dyad [active] 1245469001365 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1245469001366 Peptidase family M23; Region: Peptidase_M23; pfam01551 1245469001367 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1245469001368 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1245469001369 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1245469001370 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1245469001371 active site 1245469001372 (T/H)XGH motif; other site 1245469001373 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1245469001374 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1245469001375 putative catalytic cysteine [active] 1245469001376 gamma-glutamyl kinase; Provisional; Region: PRK05429 1245469001377 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1245469001378 nucleotide binding site [chemical binding]; other site 1245469001379 homotetrameric interface [polypeptide binding]; other site 1245469001380 putative phosphate binding site [ion binding]; other site 1245469001381 putative allosteric binding site; other site 1245469001382 PUA domain; Region: PUA; pfam01472 1245469001383 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1245469001384 GTP1/OBG; Region: GTP1_OBG; pfam01018 1245469001385 Obg GTPase; Region: Obg; cd01898 1245469001386 G1 box; other site 1245469001387 GTP/Mg2+ binding site [chemical binding]; other site 1245469001388 Switch I region; other site 1245469001389 G2 box; other site 1245469001390 G3 box; other site 1245469001391 Switch II region; other site 1245469001392 G4 box; other site 1245469001393 G5 box; other site 1245469001394 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469001395 Putative exonuclease, RdgC; Region: RdgC; cl01122 1245469001396 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1245469001397 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469001398 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1245469001399 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1245469001400 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1245469001401 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1245469001402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1245469001403 nucleotide binding site [chemical binding]; other site 1245469001404 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469001405 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1245469001406 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1245469001407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 1245469001408 SEC-C motif; Region: SEC-C; pfam02810 1245469001409 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1245469001410 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469001411 S-adenosylmethionine binding site [chemical binding]; other site 1245469001412 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1245469001413 Ligand binding site; other site 1245469001414 Putative Catalytic site; other site 1245469001415 DXD motif; other site 1245469001416 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469001417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469001418 DNA-binding site [nucleotide binding]; DNA binding site 1245469001419 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1245469001420 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1245469001421 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1245469001422 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469001423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469001424 Walker A/P-loop; other site 1245469001425 ATP binding site [chemical binding]; other site 1245469001426 Q-loop/lid; other site 1245469001427 ABC transporter signature motif; other site 1245469001428 Walker B; other site 1245469001429 D-loop; other site 1245469001430 H-loop/switch region; other site 1245469001431 TOBE domain; Region: TOBE_2; pfam08402 1245469001432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469001433 dimer interface [polypeptide binding]; other site 1245469001434 conserved gate region; other site 1245469001435 putative PBP binding loops; other site 1245469001436 ABC-ATPase subunit interface; other site 1245469001437 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469001438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469001439 dimer interface [polypeptide binding]; other site 1245469001440 conserved gate region; other site 1245469001441 putative PBP binding loops; other site 1245469001442 ABC-ATPase subunit interface; other site 1245469001443 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1245469001444 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1245469001445 active site 1245469001446 catalytic site [active] 1245469001447 tetramer interface [polypeptide binding]; other site 1245469001448 NAD-dependent deacetylase; Provisional; Region: PRK05333 1245469001449 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1245469001450 NAD+ binding site [chemical binding]; other site 1245469001451 substrate binding site [chemical binding]; other site 1245469001452 Zn binding site [ion binding]; other site 1245469001453 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1245469001454 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 1245469001455 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 1245469001456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469001457 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1245469001458 putative ADP-binding pocket [chemical binding]; other site 1245469001459 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1245469001460 Chain length determinant protein; Region: Wzz; cl15801 1245469001461 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1245469001462 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1245469001463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469001464 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1245469001465 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1245469001466 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1245469001467 putative active site [active] 1245469001468 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1245469001469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469001470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469001471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1245469001472 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1245469001473 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1245469001474 NADP-binding site; other site 1245469001475 homotetramer interface [polypeptide binding]; other site 1245469001476 substrate binding site [chemical binding]; other site 1245469001477 homodimer interface [polypeptide binding]; other site 1245469001478 active site 1245469001479 indolepyruvate/phenylpyruvate decarboxylase, Azospirillum family; Region: indol_phenyl_DC; TIGR03394 1245469001480 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1245469001481 PYR/PP interface [polypeptide binding]; other site 1245469001482 dimer interface [polypeptide binding]; other site 1245469001483 TPP binding site [chemical binding]; other site 1245469001484 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469001485 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1245469001486 TPP-binding site [chemical binding]; other site 1245469001487 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469001488 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469001489 DNA binding residues [nucleotide binding] 1245469001490 dimerization interface [polypeptide binding]; other site 1245469001491 Cache domain; Region: Cache_1; pfam02743 1245469001492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469001493 dimer interface [polypeptide binding]; other site 1245469001494 phosphorylation site [posttranslational modification] 1245469001495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469001496 ATP binding site [chemical binding]; other site 1245469001497 Mg2+ binding site [ion binding]; other site 1245469001498 G-X-G motif; other site 1245469001499 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001501 active site 1245469001502 phosphorylation site [posttranslational modification] 1245469001503 intermolecular recognition site; other site 1245469001504 dimerization interface [polypeptide binding]; other site 1245469001505 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1245469001506 putative binding surface; other site 1245469001507 active site 1245469001508 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001510 active site 1245469001511 phosphorylation site [posttranslational modification] 1245469001512 intermolecular recognition site; other site 1245469001513 dimerization interface [polypeptide binding]; other site 1245469001514 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1245469001515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001516 active site 1245469001517 phosphorylation site [posttranslational modification] 1245469001518 intermolecular recognition site; other site 1245469001519 dimerization interface [polypeptide binding]; other site 1245469001520 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469001521 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469001522 ligand binding site [chemical binding]; other site 1245469001523 flexible hinge region; other site 1245469001524 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469001525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469001526 phosphorylation site [posttranslational modification] 1245469001527 dimer interface [polypeptide binding]; other site 1245469001528 flagellin; Reviewed; Region: PRK12688 1245469001529 flagellin; Reviewed; Region: PRK12688 1245469001530 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791 1245469001531 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1245469001532 putative binding surface; other site 1245469001533 active site 1245469001534 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1245469001535 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1245469001536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469001537 ATP binding site [chemical binding]; other site 1245469001538 Mg2+ binding site [ion binding]; other site 1245469001539 G-X-G motif; other site 1245469001540 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1245469001541 CheW-like domain; Region: CheW; pfam01584 1245469001542 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001544 active site 1245469001545 phosphorylation site [posttranslational modification] 1245469001546 intermolecular recognition site; other site 1245469001547 dimerization interface [polypeptide binding]; other site 1245469001548 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1245469001549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001550 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001551 active site 1245469001552 phosphorylation site [posttranslational modification] 1245469001553 intermolecular recognition site; other site 1245469001554 dimerization interface [polypeptide binding]; other site 1245469001555 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1245469001556 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1245469001557 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1245469001558 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001560 active site 1245469001561 phosphorylation site [posttranslational modification] 1245469001562 intermolecular recognition site; other site 1245469001563 dimerization interface [polypeptide binding]; other site 1245469001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001565 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1245469001566 active site 1245469001567 phosphorylation site [posttranslational modification] 1245469001568 intermolecular recognition site; other site 1245469001569 dimerization interface [polypeptide binding]; other site 1245469001570 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469001571 DNA binding residues [nucleotide binding] 1245469001572 dimerization interface [polypeptide binding]; other site 1245469001573 HAMP domain; Region: HAMP; pfam00672 1245469001574 PAS domain S-box; Region: sensory_box; TIGR00229 1245469001575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469001576 putative active site [active] 1245469001577 heme pocket [chemical binding]; other site 1245469001578 PAS domain S-box; Region: sensory_box; TIGR00229 1245469001579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469001580 putative active site [active] 1245469001581 heme pocket [chemical binding]; other site 1245469001582 PAS domain S-box; Region: sensory_box; TIGR00229 1245469001583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469001584 putative active site [active] 1245469001585 heme pocket [chemical binding]; other site 1245469001586 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469001587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469001588 dimer interface [polypeptide binding]; other site 1245469001589 phosphorylation site [posttranslational modification] 1245469001590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469001591 ATP binding site [chemical binding]; other site 1245469001592 G-X-G motif; other site 1245469001593 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469001594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001595 active site 1245469001596 phosphorylation site [posttranslational modification] 1245469001597 intermolecular recognition site; other site 1245469001598 dimerization interface [polypeptide binding]; other site 1245469001599 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001601 active site 1245469001602 phosphorylation site [posttranslational modification] 1245469001603 intermolecular recognition site; other site 1245469001604 dimerization interface [polypeptide binding]; other site 1245469001605 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469001606 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469001607 dimer interface [polypeptide binding]; other site 1245469001608 putative CheW interface [polypeptide binding]; other site 1245469001609 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469001610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469001611 DNA-binding site [nucleotide binding]; DNA binding site 1245469001612 FCD domain; Region: FCD; pfam07729 1245469001613 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469001614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469001615 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469001616 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469001617 Walker A/P-loop; other site 1245469001618 ATP binding site [chemical binding]; other site 1245469001619 Q-loop/lid; other site 1245469001620 ABC transporter signature motif; other site 1245469001621 Walker B; other site 1245469001622 D-loop; other site 1245469001623 H-loop/switch region; other site 1245469001624 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469001625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469001626 putative PBP binding loops; other site 1245469001627 ABC-ATPase subunit interface; other site 1245469001628 dihydroxy-acid dehydratase; Provisional; Region: PRK13016 1245469001629 hypothetical protein; Validated; Region: PRK08245 1245469001630 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1245469001631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469001632 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469001633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469001634 catalytic residue [active] 1245469001635 Staphylococcal nuclease homologues; Region: SNc; smart00318 1245469001636 Catalytic site; other site 1245469001637 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1245469001638 Caspase domain; Region: Peptidase_C14; pfam00656 1245469001639 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469001640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469001641 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469001642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469001643 Caspase domain; Region: Peptidase_C14; pfam00656 1245469001644 TPR repeat; Region: TPR_11; pfam13414 1245469001645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469001646 binding surface 1245469001647 TPR motif; other site 1245469001648 TPR repeat; Region: TPR_11; pfam13414 1245469001649 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469001650 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469001651 ligand binding site [chemical binding]; other site 1245469001652 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469001653 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1245469001654 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1245469001655 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469001656 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469001657 ligand binding site [chemical binding]; other site 1245469001658 flexible hinge region; other site 1245469001659 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469001660 AsmA family; Region: AsmA; pfam05170 1245469001661 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1245469001662 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1245469001663 dimerization interface [polypeptide binding]; other site 1245469001664 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469001665 GAF domain; Region: GAF; pfam01590 1245469001666 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469001667 cyclase homology domain; Region: CHD; cd07302 1245469001668 nucleotidyl binding site; other site 1245469001669 metal binding site [ion binding]; metal-binding site 1245469001670 dimer interface [polypeptide binding]; other site 1245469001671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469001672 MarR family; Region: MarR_2; pfam12802 1245469001673 MarR family; Region: MarR_2; cl17246 1245469001674 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1245469001675 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469001676 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1245469001677 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 1245469001678 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469001679 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1245469001680 fumarylacetoacetase; Region: PLN02856 1245469001681 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1245469001682 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469001683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1245469001684 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1245469001685 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469001686 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469001687 putative DNA binding site [nucleotide binding]; other site 1245469001688 putative Zn2+ binding site [ion binding]; other site 1245469001689 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469001690 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1245469001691 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1245469001692 dimer interface [polypeptide binding]; other site 1245469001693 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1245469001694 active site 1245469001695 Fe binding site [ion binding]; other site 1245469001696 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469001697 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469001698 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469001699 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1245469001700 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469001701 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469001702 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469001703 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469001704 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469001705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469001706 dimerization interface [polypeptide binding]; other site 1245469001707 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469001708 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469001709 dimer interface [polypeptide binding]; other site 1245469001710 putative CheW interface [polypeptide binding]; other site 1245469001711 benzoate transport; Region: 2A0115; TIGR00895 1245469001712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469001713 putative substrate translocation pore; other site 1245469001714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469001715 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1245469001716 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1245469001717 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1245469001718 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1245469001719 active site 1245469001720 homotetramer interface [polypeptide binding]; other site 1245469001721 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1245469001722 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1245469001723 active site 1245469001724 Int/Topo IB signature motif; other site 1245469001725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469001726 non-specific DNA binding site [nucleotide binding]; other site 1245469001727 salt bridge; other site 1245469001728 sequence-specific DNA binding site [nucleotide binding]; other site 1245469001729 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1245469001730 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 1245469001731 MobA/MobL family; Region: MobA_MobL; pfam03389 1245469001732 AAA domain; Region: AAA_30; pfam13604 1245469001733 Family description; Region: UvrD_C_2; pfam13538 1245469001734 Conjugal transfer protein TraD; Region: TraD; cl05753 1245469001735 Conjugal transfer protein TraD; Region: TraD; pfam06412 1245469001736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469001737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469001738 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469001739 putative effector binding pocket; other site 1245469001740 dimerization interface [polypeptide binding]; other site 1245469001741 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1245469001742 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469001743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469001744 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469001745 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469001746 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469001747 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1245469001748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469001749 dimerization interface [polypeptide binding]; other site 1245469001750 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469001751 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469001752 dimer interface [polypeptide binding]; other site 1245469001753 putative CheW interface [polypeptide binding]; other site 1245469001754 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1245469001755 nudix motif; other site 1245469001756 Protein of unknown function (DUF763); Region: DUF763; pfam05559 1245469001757 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904 1245469001758 Proline dehydrogenase; Region: Pro_dh; pfam01619 1245469001759 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1245469001760 Glutamate binding site [chemical binding]; other site 1245469001761 NAD binding site [chemical binding]; other site 1245469001762 catalytic residues [active] 1245469001763 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1245469001764 conserved cys residue [active] 1245469001765 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1245469001766 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1245469001767 homodimer interface [polypeptide binding]; other site 1245469001768 substrate-cofactor binding pocket; other site 1245469001769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469001770 catalytic residue [active] 1245469001771 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469001772 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1245469001773 substrate binding pocket [chemical binding]; other site 1245469001774 aminotransferase; Provisional; Region: PRK13356 1245469001775 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1245469001776 homodimer interface [polypeptide binding]; other site 1245469001777 substrate-cofactor binding pocket; other site 1245469001778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469001779 catalytic residue [active] 1245469001780 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 1245469001781 dimer interface [polypeptide binding]; other site 1245469001782 motif 1; other site 1245469001783 active site 1245469001784 motif 2; other site 1245469001785 motif 3; other site 1245469001786 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469001787 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1245469001788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469001789 acyl carrier protein; Provisional; Region: PRK07081 1245469001790 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 1245469001791 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1245469001792 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1245469001793 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 1245469001794 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469001795 motif II; other site 1245469001796 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1245469001797 active site 1245469001798 substrate binding sites [chemical binding]; other site 1245469001799 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1245469001800 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469001801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001802 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469001803 active site 1245469001804 phosphorylation site [posttranslational modification] 1245469001805 intermolecular recognition site; other site 1245469001806 dimerization interface [polypeptide binding]; other site 1245469001807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469001808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469001809 DNA binding residues [nucleotide binding] 1245469001810 dimerization interface [polypeptide binding]; other site 1245469001811 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1245469001812 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469001813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469001814 dimer interface [polypeptide binding]; other site 1245469001815 phosphorylation site [posttranslational modification] 1245469001816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469001817 ATP binding site [chemical binding]; other site 1245469001818 Mg2+ binding site [ion binding]; other site 1245469001819 G-X-G motif; other site 1245469001820 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469001821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001822 active site 1245469001823 phosphorylation site [posttranslational modification] 1245469001824 intermolecular recognition site; other site 1245469001825 dimerization interface [polypeptide binding]; other site 1245469001826 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469001827 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1245469001828 putative ligand binding site [chemical binding]; other site 1245469001829 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469001830 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469001831 TM-ABC transporter signature motif; other site 1245469001832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469001833 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469001834 TM-ABC transporter signature motif; other site 1245469001835 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1245469001836 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469001837 Walker A/P-loop; other site 1245469001838 ATP binding site [chemical binding]; other site 1245469001839 Q-loop/lid; other site 1245469001840 ABC transporter signature motif; other site 1245469001841 Walker B; other site 1245469001842 D-loop; other site 1245469001843 H-loop/switch region; other site 1245469001844 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1245469001845 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469001846 Walker A/P-loop; other site 1245469001847 ATP binding site [chemical binding]; other site 1245469001848 Q-loop/lid; other site 1245469001849 ABC transporter signature motif; other site 1245469001850 Walker B; other site 1245469001851 D-loop; other site 1245469001852 H-loop/switch region; other site 1245469001853 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1245469001854 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1245469001855 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1245469001856 mce related protein; Region: MCE; pfam02470 1245469001857 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 1245469001858 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1245469001859 active site 1245469001860 catalytic site [active] 1245469001861 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1245469001862 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1245469001863 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 1245469001864 metal ion-dependent adhesion site (MIDAS); other site 1245469001865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469001866 sequence-specific DNA binding site [nucleotide binding]; other site 1245469001867 salt bridge; other site 1245469001868 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469001869 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469001870 putative ligand binding site [chemical binding]; other site 1245469001871 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469001872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469001873 active site 1245469001874 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469001875 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469001876 active site 1245469001877 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469001878 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1245469001879 putative C-terminal domain interface [polypeptide binding]; other site 1245469001880 putative GSH binding site (G-site) [chemical binding]; other site 1245469001881 putative dimer interface [polypeptide binding]; other site 1245469001882 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469001883 N-terminal domain interface [polypeptide binding]; other site 1245469001884 dimer interface [polypeptide binding]; other site 1245469001885 substrate binding pocket (H-site) [chemical binding]; other site 1245469001886 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469001887 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1245469001888 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1245469001889 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1245469001890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469001891 motif II; other site 1245469001892 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1245469001893 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1245469001894 acyl-CoA synthetase; Validated; Region: PRK08316 1245469001895 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469001896 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469001897 acyl-activating enzyme (AAE) consensus motif; other site 1245469001898 acyl-activating enzyme (AAE) consensus motif; other site 1245469001899 putative AMP binding site [chemical binding]; other site 1245469001900 putative active site [active] 1245469001901 putative CoA binding site [chemical binding]; other site 1245469001902 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1245469001903 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1245469001904 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1245469001905 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469001906 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1245469001907 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1245469001908 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1245469001909 carboxyltransferase (CT) interaction site; other site 1245469001910 biotinylation site [posttranslational modification]; other site 1245469001911 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469001912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469001913 active site 1245469001914 phosphorylation site [posttranslational modification] 1245469001915 intermolecular recognition site; other site 1245469001916 dimerization interface [polypeptide binding]; other site 1245469001917 PAS domain S-box; Region: sensory_box; TIGR00229 1245469001918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469001919 putative active site [active] 1245469001920 heme pocket [chemical binding]; other site 1245469001921 PAS domain S-box; Region: sensory_box; TIGR00229 1245469001922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469001923 putative active site [active] 1245469001924 heme pocket [chemical binding]; other site 1245469001925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469001926 HWE histidine kinase; Region: HWE_HK; smart00911 1245469001927 Cytochrome c; Region: Cytochrom_C; cl11414 1245469001928 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1245469001929 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469001930 BON domain; Region: BON; pfam04972 1245469001931 acyl-CoA synthetase; Provisional; Region: PRK13391 1245469001932 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469001933 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469001934 acyl-activating enzyme (AAE) consensus motif; other site 1245469001935 acyl-activating enzyme (AAE) consensus motif; other site 1245469001936 putative AMP binding site [chemical binding]; other site 1245469001937 putative active site [active] 1245469001938 putative CoA binding site [chemical binding]; other site 1245469001939 CoA binding site [chemical binding]; other site 1245469001940 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469001941 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469001942 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469001943 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1245469001944 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469001945 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469001946 putative ligand binding site [chemical binding]; other site 1245469001947 MAPEG family; Region: MAPEG; pfam01124 1245469001948 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1245469001949 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1245469001950 FtsX-like permease family; Region: FtsX; pfam02687 1245469001951 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469001952 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469001953 Walker A/P-loop; other site 1245469001954 ATP binding site [chemical binding]; other site 1245469001955 Q-loop/lid; other site 1245469001956 ABC transporter signature motif; other site 1245469001957 Walker B; other site 1245469001958 D-loop; other site 1245469001959 H-loop/switch region; other site 1245469001960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469001961 D-galactonate transporter; Region: 2A0114; TIGR00893 1245469001962 putative substrate translocation pore; other site 1245469001963 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1245469001964 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1245469001965 active site 1245469001966 putative substrate binding pocket [chemical binding]; other site 1245469001967 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469001968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469001969 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1245469001970 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1245469001971 active site residue [active] 1245469001972 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 1245469001973 active site 1245469001974 metal binding site [ion binding]; metal-binding site 1245469001975 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1245469001976 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1245469001977 Cytochrome c [Energy production and conversion]; Region: COG3258 1245469001978 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1245469001979 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1245469001980 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1245469001981 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469001982 Protein of unknown function (DUF938); Region: DUF938; pfam06080 1245469001983 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1245469001984 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469001985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469001986 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1245469001987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469001988 active site 1245469001989 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1245469001990 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1245469001991 active site 1245469001992 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1245469001993 Fasciclin domain; Region: Fasciclin; pfam02469 1245469001994 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1245469001995 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469001996 substrate binding pocket [chemical binding]; other site 1245469001997 membrane-bound complex binding site; other site 1245469001998 hinge residues; other site 1245469001999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469002000 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469002001 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1245469002002 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1245469002003 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1245469002004 RNA polymerase sigma factor; Provisional; Region: PRK12515 1245469002005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469002006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469002007 DNA binding residues [nucleotide binding] 1245469002008 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1245469002009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469002010 active site 1245469002011 phosphorylation site [posttranslational modification] 1245469002012 intermolecular recognition site; other site 1245469002013 dimerization interface [polypeptide binding]; other site 1245469002014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469002015 DNA binding site [nucleotide binding] 1245469002016 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469002017 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1245469002018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469002019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469002020 dimer interface [polypeptide binding]; other site 1245469002021 phosphorylation site [posttranslational modification] 1245469002022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469002023 ATP binding site [chemical binding]; other site 1245469002024 Mg2+ binding site [ion binding]; other site 1245469002025 G-X-G motif; other site 1245469002026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469002027 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469002028 dimerization interface [polypeptide binding]; other site 1245469002029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469002030 ATP binding site [chemical binding]; other site 1245469002031 Mg2+ binding site [ion binding]; other site 1245469002032 G-X-G motif; other site 1245469002033 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469002034 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469002035 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469002036 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1245469002037 ATP binding site [chemical binding]; other site 1245469002038 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469002039 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1245469002040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002042 dimer interface [polypeptide binding]; other site 1245469002043 conserved gate region; other site 1245469002044 putative PBP binding loops; other site 1245469002045 ABC-ATPase subunit interface; other site 1245469002046 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1245469002047 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469002048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002049 dimer interface [polypeptide binding]; other site 1245469002050 conserved gate region; other site 1245469002051 putative PBP binding loops; other site 1245469002052 ABC-ATPase subunit interface; other site 1245469002053 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469002054 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469002055 Walker A/P-loop; other site 1245469002056 ATP binding site [chemical binding]; other site 1245469002057 Q-loop/lid; other site 1245469002058 ABC transporter signature motif; other site 1245469002059 Walker B; other site 1245469002060 D-loop; other site 1245469002061 H-loop/switch region; other site 1245469002062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1245469002063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469002064 Walker A/P-loop; other site 1245469002065 ATP binding site [chemical binding]; other site 1245469002066 Q-loop/lid; other site 1245469002067 ABC transporter signature motif; other site 1245469002068 Walker B; other site 1245469002069 D-loop; other site 1245469002070 H-loop/switch region; other site 1245469002071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469002072 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 1245469002073 amidase; Provisional; Region: PRK09201 1245469002074 Amidase; Region: Amidase; cl11426 1245469002075 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1245469002076 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469002077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469002078 DNA-binding site [nucleotide binding]; DNA binding site 1245469002079 FCD domain; Region: FCD; pfam07729 1245469002080 allophanate hydrolase; Provisional; Region: PRK08186 1245469002081 Amidase; Region: Amidase; cl11426 1245469002082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469002083 MarR family; Region: MarR_2; pfam12802 1245469002084 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469002085 Cytochrome P450; Region: p450; cl12078 1245469002086 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469002087 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469002088 catalytic loop [active] 1245469002089 iron binding site [ion binding]; other site 1245469002090 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469002091 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469002092 putative ligand binding site [chemical binding]; other site 1245469002093 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469002094 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1245469002095 putative ligand binding site [chemical binding]; other site 1245469002096 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469002097 TM-ABC transporter signature motif; other site 1245469002098 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469002099 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469002100 TM-ABC transporter signature motif; other site 1245469002101 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469002102 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469002103 Walker A/P-loop; other site 1245469002104 ATP binding site [chemical binding]; other site 1245469002105 Q-loop/lid; other site 1245469002106 ABC transporter signature motif; other site 1245469002107 Walker B; other site 1245469002108 D-loop; other site 1245469002109 H-loop/switch region; other site 1245469002110 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469002111 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469002112 Walker A/P-loop; other site 1245469002113 ATP binding site [chemical binding]; other site 1245469002114 Q-loop/lid; other site 1245469002115 ABC transporter signature motif; other site 1245469002116 Walker B; other site 1245469002117 D-loop; other site 1245469002118 H-loop/switch region; other site 1245469002119 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469002120 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1245469002121 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469002122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002123 dimer interface [polypeptide binding]; other site 1245469002124 conserved gate region; other site 1245469002125 putative PBP binding loops; other site 1245469002126 ABC-ATPase subunit interface; other site 1245469002127 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469002128 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469002129 Walker A/P-loop; other site 1245469002130 ATP binding site [chemical binding]; other site 1245469002131 Q-loop/lid; other site 1245469002132 ABC transporter signature motif; other site 1245469002133 Walker B; other site 1245469002134 D-loop; other site 1245469002135 H-loop/switch region; other site 1245469002136 agmatinase; Region: agmatinase; TIGR01230 1245469002137 Agmatinase-like family; Region: Agmatinase-like; cd09990 1245469002138 active site 1245469002139 oligomer interface [polypeptide binding]; other site 1245469002140 Mn binding site [ion binding]; other site 1245469002141 anaerobic benzoate catabolism transcriptional regulator; Reviewed; Region: PRK08154 1245469002142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469002143 non-specific DNA binding site [nucleotide binding]; other site 1245469002144 salt bridge; other site 1245469002145 sequence-specific DNA binding site [nucleotide binding]; other site 1245469002146 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1245469002147 ADP binding site [chemical binding]; other site 1245469002148 magnesium binding site [ion binding]; other site 1245469002149 putative shikimate binding site; other site 1245469002150 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1245469002151 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 1245469002152 dimer interface [polypeptide binding]; other site 1245469002153 acyl-activating enzyme (AAE) consensus motif; other site 1245469002154 putative active site [active] 1245469002155 putative AMP binding site [chemical binding]; other site 1245469002156 putative CoA binding site [chemical binding]; other site 1245469002157 chemical substrate binding site [chemical binding]; other site 1245469002158 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469002159 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 1245469002160 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469002161 substrate binding site [chemical binding]; other site 1245469002162 oxyanion hole (OAH) forming residues; other site 1245469002163 trimer interface [polypeptide binding]; other site 1245469002164 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1245469002165 substrate binding site [chemical binding]; other site 1245469002166 oxyanion hole (OAH) forming residues; other site 1245469002167 trimer interface [polypeptide binding]; other site 1245469002168 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 1245469002169 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1245469002170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469002171 NAD(P) binding site [chemical binding]; other site 1245469002172 active site 1245469002173 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1245469002174 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1245469002175 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1245469002176 putative active site [active] 1245469002177 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469002178 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469002179 ligand binding site [chemical binding]; other site 1245469002180 Predicted integral membrane protein [Function unknown]; Region: COG0392 1245469002181 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1245469002182 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469002183 dimer interface [polypeptide binding]; other site 1245469002184 phosphorylation site [posttranslational modification] 1245469002185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469002186 ATP binding site [chemical binding]; other site 1245469002187 Mg2+ binding site [ion binding]; other site 1245469002188 G-X-G motif; other site 1245469002189 GcrA cell cycle regulator; Region: GcrA; pfam07750 1245469002190 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 1245469002191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469002192 inhibitor-cofactor binding pocket; inhibition site 1245469002193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469002194 catalytic residue [active] 1245469002195 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1245469002196 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1245469002197 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1245469002198 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1245469002199 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1245469002200 dimerization interface [polypeptide binding]; other site 1245469002201 domain crossover interface; other site 1245469002202 redox-dependent activation switch; other site 1245469002203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469002204 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469002205 WHG domain; Region: WHG; pfam13305 1245469002206 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469002207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469002208 NAD(P) binding site [chemical binding]; other site 1245469002209 active site 1245469002210 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1245469002211 OpgC protein; Region: OpgC_C; pfam10129 1245469002212 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1245469002213 active site 1245469002214 catalytic triad [active] 1245469002215 oxyanion hole [active] 1245469002216 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1245469002217 active site 1245469002218 catalytic triad [active] 1245469002219 oxyanion hole [active] 1245469002220 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 1245469002221 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1245469002222 homodimer interface [polypeptide binding]; other site 1245469002223 substrate-cofactor binding pocket; other site 1245469002224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469002225 catalytic residue [active] 1245469002226 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 1245469002227 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1245469002228 trimer interface [polypeptide binding]; other site 1245469002229 active site 1245469002230 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1245469002231 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 1245469002232 putative efflux protein, MATE family; Region: matE; TIGR00797 1245469002233 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1245469002234 putative hydrophobic ligand binding site [chemical binding]; other site 1245469002235 protein interface [polypeptide binding]; other site 1245469002236 gate; other site 1245469002237 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1245469002238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469002239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469002240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469002241 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1245469002242 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1245469002243 DNA binding site [nucleotide binding] 1245469002244 active site 1245469002245 SPW repeat; Region: SPW; pfam03779 1245469002246 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1245469002247 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1245469002248 acyl-activating enzyme (AAE) consensus motif; other site 1245469002249 putative AMP binding site [chemical binding]; other site 1245469002250 putative active site [active] 1245469002251 putative CoA binding site [chemical binding]; other site 1245469002252 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469002253 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1245469002254 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1245469002255 Cu(I) binding site [ion binding]; other site 1245469002256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469002257 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469002258 substrate binding pocket [chemical binding]; other site 1245469002259 membrane-bound complex binding site; other site 1245469002260 hinge residues; other site 1245469002261 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1245469002262 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469002263 active site 1245469002264 nucleotide binding site [chemical binding]; other site 1245469002265 HIGH motif; other site 1245469002266 KMSKS motif; other site 1245469002267 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 1245469002268 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 1245469002269 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1245469002270 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1245469002271 active site 1245469002272 zinc binding site [ion binding]; other site 1245469002273 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1245469002274 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1245469002275 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1245469002276 quinone interaction residues [chemical binding]; other site 1245469002277 active site 1245469002278 catalytic residues [active] 1245469002279 FMN binding site [chemical binding]; other site 1245469002280 substrate binding site [chemical binding]; other site 1245469002281 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1245469002282 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1245469002283 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1245469002284 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1245469002285 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1245469002286 active site 1245469002287 DNA binding site [nucleotide binding] 1245469002288 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1245469002289 DNA binding site [nucleotide binding] 1245469002290 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1245469002291 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469002292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469002293 binding surface 1245469002294 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 1245469002295 TPR motif; other site 1245469002296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469002297 S-adenosylmethionine binding site [chemical binding]; other site 1245469002298 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469002299 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469002300 putative ligand binding site [chemical binding]; other site 1245469002301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1245469002302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469002303 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1245469002304 putative Mg++ binding site [ion binding]; other site 1245469002305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469002306 nucleotide binding region [chemical binding]; other site 1245469002307 ATP-binding site [chemical binding]; other site 1245469002308 DEAD/H associated; Region: DEAD_assoc; pfam08494 1245469002309 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469002310 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1245469002311 putative active site [active] 1245469002312 putative metal binding site [ion binding]; other site 1245469002313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469002314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469002315 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1245469002316 dimerization interface [polypeptide binding]; other site 1245469002317 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1245469002318 EamA-like transporter family; Region: EamA; pfam00892 1245469002319 EamA-like transporter family; Region: EamA; pfam00892 1245469002320 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1245469002321 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1245469002322 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 1245469002323 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469002324 Predicted periplasmic protein [Function unknown]; Region: COG3904 1245469002325 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469002326 Sel1-like repeats; Region: SEL1; smart00671 1245469002327 Sel1-like repeats; Region: SEL1; smart00671 1245469002328 Sel1-like repeats; Region: SEL1; smart00671 1245469002329 Sel1-like repeats; Region: SEL1; smart00671 1245469002330 Predicted transcriptional regulators [Transcription]; Region: COG1695 1245469002331 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1245469002332 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1245469002333 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469002334 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1245469002335 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1245469002336 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1245469002337 FAD binding site [chemical binding]; other site 1245469002338 substrate binding site [chemical binding]; other site 1245469002339 catalytic residues [active] 1245469002340 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1245469002341 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1245469002342 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469002343 dimer interface [polypeptide binding]; other site 1245469002344 active site 1245469002345 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1245469002346 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469002347 substrate binding site [chemical binding]; other site 1245469002348 oxyanion hole (OAH) forming residues; other site 1245469002349 trimer interface [polypeptide binding]; other site 1245469002350 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469002351 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469002352 Putative addiction module component; Region: Unstab_antitox; pfam09720 1245469002353 glutathionine S-transferase; Provisional; Region: PRK10542 1245469002354 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1245469002355 C-terminal domain interface [polypeptide binding]; other site 1245469002356 GSH binding site (G-site) [chemical binding]; other site 1245469002357 dimer interface [polypeptide binding]; other site 1245469002358 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1245469002359 N-terminal domain interface [polypeptide binding]; other site 1245469002360 dimer interface [polypeptide binding]; other site 1245469002361 substrate binding pocket (H-site) [chemical binding]; other site 1245469002362 MarR family; Region: MarR_2; pfam12802 1245469002363 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469002364 glutamate--cysteine ligase; Region: PLN02611 1245469002365 PAN domain; Region: PAN_4; pfam14295 1245469002366 putative binding site; other site 1245469002367 PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech...; Region: PAN_APPLE; cl00112 1245469002368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1245469002369 catalytic residues [active] 1245469002370 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1245469002371 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1245469002372 Protein of unknown function (DUF419); Region: DUF419; cl15265 1245469002373 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1245469002374 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1245469002375 Catalytic site [active] 1245469002376 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1245469002377 protease TldD; Provisional; Region: tldD; PRK10735 1245469002378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1245469002379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469002380 Coenzyme A binding pocket [chemical binding]; other site 1245469002381 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 1245469002382 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1245469002383 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154 1245469002384 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1245469002385 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1245469002386 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 1245469002387 Subunit I/III interface [polypeptide binding]; other site 1245469002388 D-pathway; other site 1245469002389 Subunit I/VIIc interface [polypeptide binding]; other site 1245469002390 Subunit I/IV interface [polypeptide binding]; other site 1245469002391 Subunit I/II interface [polypeptide binding]; other site 1245469002392 Low-spin heme (heme a) binding site [chemical binding]; other site 1245469002393 Subunit I/VIIa interface [polypeptide binding]; other site 1245469002394 Subunit I/VIa interface [polypeptide binding]; other site 1245469002395 Dimer interface; other site 1245469002396 Putative water exit pathway; other site 1245469002397 Binuclear center (heme a3/CuB) [ion binding]; other site 1245469002398 K-pathway; other site 1245469002399 Subunit I/Vb interface [polypeptide binding]; other site 1245469002400 Putative proton exit pathway; other site 1245469002401 Subunit I/VIb interface; other site 1245469002402 Subunit I/VIc interface [polypeptide binding]; other site 1245469002403 Electron transfer pathway; other site 1245469002404 Subunit I/VIIIb interface [polypeptide binding]; other site 1245469002405 Subunit I/VIIb interface [polypeptide binding]; other site 1245469002406 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1245469002407 UbiA prenyltransferase family; Region: UbiA; pfam01040 1245469002408 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 1245469002409 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 1245469002410 Subunit III/VIIa interface [polypeptide binding]; other site 1245469002411 Phospholipid binding site [chemical binding]; other site 1245469002412 Subunit I/III interface [polypeptide binding]; other site 1245469002413 Subunit III/VIb interface [polypeptide binding]; other site 1245469002414 Subunit III/VIa interface; other site 1245469002415 Subunit III/Vb interface [polypeptide binding]; other site 1245469002416 Protein of unknown function (DUF983); Region: DUF983; cl02211 1245469002417 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1245469002418 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1245469002419 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1245469002420 DNA binding residues [nucleotide binding] 1245469002421 putative dimer interface [polypeptide binding]; other site 1245469002422 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1245469002423 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1245469002424 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 1245469002425 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1245469002426 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1245469002427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469002428 catalytic residue [active] 1245469002429 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1245469002430 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1245469002431 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1245469002432 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1245469002433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1245469002434 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 1245469002435 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1245469002436 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1245469002437 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1245469002438 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 1245469002439 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1245469002440 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1245469002441 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1245469002442 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1245469002443 putative catalytic residue [active] 1245469002444 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1245469002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469002446 putative substrate translocation pore; other site 1245469002447 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469002448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469002449 active site 1245469002450 phosphorylation site [posttranslational modification] 1245469002451 intermolecular recognition site; other site 1245469002452 dimerization interface [polypeptide binding]; other site 1245469002453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469002454 DNA binding residues [nucleotide binding] 1245469002455 dimerization interface [polypeptide binding]; other site 1245469002456 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1245469002457 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469002458 non-specific DNA binding site [nucleotide binding]; other site 1245469002459 salt bridge; other site 1245469002460 sequence-specific DNA binding site [nucleotide binding]; other site 1245469002461 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1245469002462 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1245469002463 Cupin; Region: Cupin_6; pfam12852 1245469002464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469002465 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469002466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469002467 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469002468 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469002469 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469002470 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469002471 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469002472 dimerization interface [polypeptide binding]; other site 1245469002473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469002474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469002475 ATP binding site [chemical binding]; other site 1245469002476 Mg2+ binding site [ion binding]; other site 1245469002477 G-X-G motif; other site 1245469002478 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469002479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469002480 active site 1245469002481 phosphorylation site [posttranslational modification] 1245469002482 intermolecular recognition site; other site 1245469002483 dimerization interface [polypeptide binding]; other site 1245469002484 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1245469002485 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1245469002486 substrate-cofactor binding pocket; other site 1245469002487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469002488 catalytic residue [active] 1245469002489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469002490 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469002491 dimerization interface [polypeptide binding]; other site 1245469002492 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469002493 dimer interface [polypeptide binding]; other site 1245469002494 putative CheW interface [polypeptide binding]; other site 1245469002495 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469002496 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469002497 dimerization interface [polypeptide binding]; other site 1245469002498 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469002499 dimer interface [polypeptide binding]; other site 1245469002500 putative CheW interface [polypeptide binding]; other site 1245469002501 PilZ domain; Region: PilZ; pfam07238 1245469002502 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469002503 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469002504 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469002505 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469002506 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1245469002507 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469002508 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469002509 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1245469002510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469002511 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1245469002512 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1245469002513 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1245469002514 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469002515 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 1245469002516 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1245469002517 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1245469002518 alpha subunit interface [polypeptide binding]; other site 1245469002519 active site 1245469002520 substrate binding site [chemical binding]; other site 1245469002521 Fe binding site [ion binding]; other site 1245469002522 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1245469002523 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1245469002524 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1245469002525 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06463 1245469002526 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1245469002527 putative NAD(P) binding site [chemical binding]; other site 1245469002528 putative active site [active] 1245469002529 histidine kinase; Provisional; Region: PRK13557 1245469002530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469002531 putative active site [active] 1245469002532 heme pocket [chemical binding]; other site 1245469002533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469002534 dimer interface [polypeptide binding]; other site 1245469002535 phosphorylation site [posttranslational modification] 1245469002536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469002537 ATP binding site [chemical binding]; other site 1245469002538 Mg2+ binding site [ion binding]; other site 1245469002539 G-X-G motif; other site 1245469002540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469002541 active site 1245469002542 phosphorylation site [posttranslational modification] 1245469002543 intermolecular recognition site; other site 1245469002544 dimerization interface [polypeptide binding]; other site 1245469002545 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1245469002546 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1245469002547 oligomer interface [polypeptide binding]; other site 1245469002548 metal binding site [ion binding]; metal-binding site 1245469002549 metal binding site [ion binding]; metal-binding site 1245469002550 putative Cl binding site [ion binding]; other site 1245469002551 basic sphincter; other site 1245469002552 hydrophobic gate; other site 1245469002553 periplasmic entrance; other site 1245469002554 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1245469002555 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469002556 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1245469002557 classical (c) SDRs; Region: SDR_c; cd05233 1245469002558 NAD(P) binding site [chemical binding]; other site 1245469002559 active site 1245469002560 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1245469002561 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1245469002562 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1245469002563 Restriction endonuclease; Region: Mrr_cat; pfam04471 1245469002564 pyruvate dehydrogenase; Provisional; Region: PRK09124 1245469002565 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1245469002566 PYR/PP interface [polypeptide binding]; other site 1245469002567 dimer interface [polypeptide binding]; other site 1245469002568 tetramer interface [polypeptide binding]; other site 1245469002569 TPP binding site [chemical binding]; other site 1245469002570 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469002571 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1245469002572 TPP-binding site [chemical binding]; other site 1245469002573 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469002574 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469002575 ligand binding site [chemical binding]; other site 1245469002576 flexible hinge region; other site 1245469002577 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1245469002578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469002579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469002580 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1245469002581 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1245469002582 hinge; other site 1245469002583 active site 1245469002584 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 1245469002585 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1245469002586 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1245469002587 NAD binding site [chemical binding]; other site 1245469002588 dimerization interface [polypeptide binding]; other site 1245469002589 product binding site; other site 1245469002590 substrate binding site [chemical binding]; other site 1245469002591 zinc binding site [ion binding]; other site 1245469002592 catalytic residues [active] 1245469002593 hypothetical protein; Provisional; Region: PRK02853 1245469002594 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1245469002595 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1245469002596 active site 1245469002597 Maf-like protein; Region: Maf; pfam02545 1245469002598 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1245469002599 active site 1245469002600 dimer interface [polypeptide binding]; other site 1245469002601 Domain of unknown function (DUF329); Region: DUF329; cl01144 1245469002602 integrase; Provisional; Region: PRK09692 1245469002603 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1245469002604 active site 1245469002605 Int/Topo IB signature motif; other site 1245469002606 Helix-turn-helix domain; Region: HTH_17; cl17695 1245469002607 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1245469002608 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469002609 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1245469002610 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1245469002611 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1245469002612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469002613 ATP binding site [chemical binding]; other site 1245469002614 putative Mg++ binding site [ion binding]; other site 1245469002615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469002616 nucleotide binding region [chemical binding]; other site 1245469002617 ATP-binding site [chemical binding]; other site 1245469002618 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1245469002619 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1245469002620 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1245469002621 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1245469002622 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469002623 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 1245469002624 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1245469002625 active site 1245469002626 catalytic site [active] 1245469002627 substrate binding site [chemical binding]; other site 1245469002628 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1245469002629 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1245469002630 ParB-like nuclease domain; Region: ParBc; pfam02195 1245469002631 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1245469002632 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 1245469002633 Helicase_C-like; Region: Helicase_C_4; pfam13871 1245469002634 Toprim domain; Region: Toprim_3; pfam13362 1245469002635 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 1245469002636 Uncharacterized conserved protein [Function unknown]; Region: COG5489 1245469002637 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469002638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469002639 AMP-binding domain protein; Validated; Region: PRK07529 1245469002640 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469002641 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1245469002642 acyl-activating enzyme (AAE) consensus motif; other site 1245469002643 putative AMP binding site [chemical binding]; other site 1245469002644 putative active site [active] 1245469002645 putative CoA binding site [chemical binding]; other site 1245469002646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469002647 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469002648 TM-ABC transporter signature motif; other site 1245469002649 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1245469002650 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469002651 ligand binding site [chemical binding]; other site 1245469002652 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469002653 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469002654 TM-ABC transporter signature motif; other site 1245469002655 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1245469002656 Strictosidine synthase; Region: Str_synth; pfam03088 1245469002657 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1245469002658 Strictosidine synthase; Region: Str_synth; pfam03088 1245469002659 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469002660 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469002661 Walker A/P-loop; other site 1245469002662 ATP binding site [chemical binding]; other site 1245469002663 Q-loop/lid; other site 1245469002664 ABC transporter signature motif; other site 1245469002665 Walker B; other site 1245469002666 D-loop; other site 1245469002667 H-loop/switch region; other site 1245469002668 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469002669 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1245469002670 NADP binding site [chemical binding]; other site 1245469002671 active site 1245469002672 putative substrate binding site [chemical binding]; other site 1245469002673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1245469002674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469002675 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469002676 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1245469002677 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1245469002678 active site 1245469002679 dimer interface [polypeptide binding]; other site 1245469002680 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1245469002681 Ligand Binding Site [chemical binding]; other site 1245469002682 Molecular Tunnel; other site 1245469002683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469002684 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469002685 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469002686 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1245469002687 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1245469002688 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1245469002689 Walker A/P-loop; other site 1245469002690 ATP binding site [chemical binding]; other site 1245469002691 Q-loop/lid; other site 1245469002692 ABC transporter signature motif; other site 1245469002693 Walker B; other site 1245469002694 D-loop; other site 1245469002695 H-loop/switch region; other site 1245469002696 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1245469002697 putative carbohydrate binding site [chemical binding]; other site 1245469002698 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469002699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469002700 NAD(P) binding site [chemical binding]; other site 1245469002701 active site 1245469002702 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1245469002703 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1245469002704 Probable Catalytic site; other site 1245469002705 metal-binding site 1245469002706 Caenorhabditis protein of unknown function, DUF268; Region: DUF268; pfam03269 1245469002707 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1245469002708 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1245469002709 trimer interface [polypeptide binding]; other site 1245469002710 active site 1245469002711 substrate binding site [chemical binding]; other site 1245469002712 CoA binding site [chemical binding]; other site 1245469002713 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469002714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469002715 S-adenosylmethionine binding site [chemical binding]; other site 1245469002716 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1245469002717 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1245469002718 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1245469002719 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469002720 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469002721 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469002722 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469002723 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1245469002724 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1245469002725 NADP-binding site; other site 1245469002726 homotetramer interface [polypeptide binding]; other site 1245469002727 substrate binding site [chemical binding]; other site 1245469002728 homodimer interface [polypeptide binding]; other site 1245469002729 active site 1245469002730 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 1245469002731 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1245469002732 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1245469002733 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1245469002734 Family description; Region: VCBS; pfam13517 1245469002735 Family description; Region: VCBS; pfam13517 1245469002736 Family description; Region: VCBS; pfam13517 1245469002737 Family description; Region: VCBS; pfam13517 1245469002738 Family description; Region: VCBS; pfam13517 1245469002739 Family description; Region: VCBS; pfam13517 1245469002740 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1245469002741 RHS Repeat; Region: RHS_repeat; pfam05593 1245469002742 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1245469002743 RHS Repeat; Region: RHS_repeat; pfam05593 1245469002744 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1245469002745 RHS protein; Region: RHS; pfam03527 1245469002746 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1245469002747 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1245469002748 Peptidase family M23; Region: Peptidase_M23; pfam01551 1245469002749 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469002750 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469002751 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1245469002752 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469002753 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1245469002754 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469002755 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469002756 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1245469002757 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1245469002758 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1245469002759 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1245469002760 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1245469002761 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1245469002762 general secretion pathway protein J; Validated; Region: PRK08808 1245469002763 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1245469002764 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1245469002765 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1245469002766 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1245469002767 Walker A motif; other site 1245469002768 ATP binding site [chemical binding]; other site 1245469002769 Walker B motif; other site 1245469002770 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1245469002771 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1245469002772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469002773 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1245469002774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469002775 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1245469002776 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1245469002777 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1245469002778 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1245469002779 Substrate binding site; other site 1245469002780 Cupin domain; Region: Cupin_2; cl17218 1245469002781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1245469002782 DNA binding site [nucleotide binding] 1245469002783 active site 1245469002784 Int/Topo IB signature motif; other site 1245469002785 Helix-turn-helix domain; Region: HTH_17; pfam12728 1245469002786 Replication initiator protein A; Region: RPA; pfam10134 1245469002787 Protein of unknown function (DUF2840); Region: DUF2840; pfam11000 1245469002788 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1245469002789 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1245469002790 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1245469002791 Transposase; Region: HTH_Tnp_1; cl17663 1245469002792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1245469002793 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1245469002794 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 1245469002795 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 1245469002796 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 1245469002797 Walker A motif; other site 1245469002798 ATP binding site [chemical binding]; other site 1245469002799 Walker B motif; other site 1245469002800 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1245469002801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469002802 D-galactonate transporter; Region: 2A0114; TIGR00893 1245469002803 putative substrate translocation pore; other site 1245469002804 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1245469002805 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1245469002806 ATP binding site [chemical binding]; other site 1245469002807 Walker A motif; other site 1245469002808 hexamer interface [polypeptide binding]; other site 1245469002809 Walker B motif; other site 1245469002810 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 1245469002811 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1245469002812 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1245469002813 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1245469002814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469002815 Walker A/P-loop; other site 1245469002816 ATP binding site [chemical binding]; other site 1245469002817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469002818 Walker B; other site 1245469002819 D-loop; other site 1245469002820 H-loop/switch region; other site 1245469002821 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 1245469002822 conjugal transfer protein TrbL; Provisional; Region: PRK13875 1245469002823 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 1245469002824 conjugal transfer protein TrbF; Provisional; Region: PRK13872 1245469002825 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1245469002826 VirB7 interaction site; other site 1245469002827 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 1245469002828 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 1245469002829 Autoinducer synthetase; Region: Autoind_synth; cl17404 1245469002830 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1245469002831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469002832 DNA binding residues [nucleotide binding] 1245469002833 dimerization interface [polypeptide binding]; other site 1245469002834 acetolactate synthase catalytic subunit; Validated; Region: PRK06112 1245469002835 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469002836 PYR/PP interface [polypeptide binding]; other site 1245469002837 dimer interface [polypeptide binding]; other site 1245469002838 TPP binding site [chemical binding]; other site 1245469002839 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469002840 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1245469002841 TPP-binding site [chemical binding]; other site 1245469002842 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1245469002843 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469002844 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469002845 catalytic residue [active] 1245469002846 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1245469002847 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469002848 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469002849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469002850 Walker A/P-loop; other site 1245469002851 ATP binding site [chemical binding]; other site 1245469002852 Q-loop/lid; other site 1245469002853 ABC transporter signature motif; other site 1245469002854 Walker B; other site 1245469002855 D-loop; other site 1245469002856 H-loop/switch region; other site 1245469002857 TOBE domain; Region: TOBE_2; pfam08402 1245469002858 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1245469002859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002860 dimer interface [polypeptide binding]; other site 1245469002861 conserved gate region; other site 1245469002862 putative PBP binding loops; other site 1245469002863 ABC-ATPase subunit interface; other site 1245469002864 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469002865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002866 dimer interface [polypeptide binding]; other site 1245469002867 conserved gate region; other site 1245469002868 putative PBP binding loops; other site 1245469002869 ABC-ATPase subunit interface; other site 1245469002870 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469002871 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469002872 DNA-binding site [nucleotide binding]; DNA binding site 1245469002873 FCD domain; Region: FCD; pfam07729 1245469002874 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1245469002875 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1245469002876 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1245469002877 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1245469002878 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1245469002879 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1245469002880 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469002881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002883 dimer interface [polypeptide binding]; other site 1245469002884 conserved gate region; other site 1245469002885 putative PBP binding loops; other site 1245469002886 ABC-ATPase subunit interface; other site 1245469002887 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469002888 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1245469002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469002890 dimer interface [polypeptide binding]; other site 1245469002891 conserved gate region; other site 1245469002892 putative PBP binding loops; other site 1245469002893 ABC-ATPase subunit interface; other site 1245469002894 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469002895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469002896 Walker A/P-loop; other site 1245469002897 ATP binding site [chemical binding]; other site 1245469002898 Q-loop/lid; other site 1245469002899 ABC transporter signature motif; other site 1245469002900 Walker B; other site 1245469002901 D-loop; other site 1245469002902 H-loop/switch region; other site 1245469002903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469002904 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469002905 Walker A/P-loop; other site 1245469002906 ATP binding site [chemical binding]; other site 1245469002907 Q-loop/lid; other site 1245469002908 ABC transporter signature motif; other site 1245469002909 Walker B; other site 1245469002910 D-loop; other site 1245469002911 H-loop/switch region; other site 1245469002912 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1245469002913 Uncharacterized conserved protein (DUF2285); Region: DUF2285; pfam10074 1245469002914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469002915 sequence-specific DNA binding site [nucleotide binding]; other site 1245469002916 salt bridge; other site 1245469002917 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1245469002918 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1245469002919 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1245469002920 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1245469002921 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469002922 Amidase; Region: Amidase; cl11426 1245469002923 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469002924 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469002925 TM-ABC transporter signature motif; other site 1245469002926 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469002927 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469002928 TM-ABC transporter signature motif; other site 1245469002929 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469002930 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469002931 Walker A/P-loop; other site 1245469002932 ATP binding site [chemical binding]; other site 1245469002933 Q-loop/lid; other site 1245469002934 ABC transporter signature motif; other site 1245469002935 Walker B; other site 1245469002936 D-loop; other site 1245469002937 H-loop/switch region; other site 1245469002938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469002939 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469002940 Walker A/P-loop; other site 1245469002941 ATP binding site [chemical binding]; other site 1245469002942 Q-loop/lid; other site 1245469002943 ABC transporter signature motif; other site 1245469002944 Walker B; other site 1245469002945 D-loop; other site 1245469002946 H-loop/switch region; other site 1245469002947 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469002948 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469002949 putative ligand binding site [chemical binding]; other site 1245469002950 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1245469002951 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1245469002952 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 1245469002953 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1245469002954 NAD(P) binding site [chemical binding]; other site 1245469002955 catalytic residues [active] 1245469002956 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469002957 EamA-like transporter family; Region: EamA; pfam00892 1245469002958 EamA-like transporter family; Region: EamA; pfam00892 1245469002959 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1245469002960 dimer interface [polypeptide binding]; other site 1245469002961 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 1245469002962 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 1245469002963 TPP-binding site; other site 1245469002964 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469002965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469002966 S-adenosylmethionine binding site [chemical binding]; other site 1245469002967 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1245469002968 tetramer interface [polypeptide binding]; other site 1245469002969 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1245469002970 active site 1245469002971 Mg2+/Mn2+ binding site [ion binding]; other site 1245469002972 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1245469002973 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1245469002974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469002975 DNA-binding site [nucleotide binding]; DNA binding site 1245469002976 UTRA domain; Region: UTRA; pfam07702 1245469002977 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469002978 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469002979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469002980 S-adenosylmethionine binding site [chemical binding]; other site 1245469002981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469002982 DNA-binding site [nucleotide binding]; DNA binding site 1245469002983 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1245469002984 UTRA domain; Region: UTRA; pfam07702 1245469002985 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469002986 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469002987 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469002988 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469002989 active site 1245469002990 metal binding site [ion binding]; metal-binding site 1245469002991 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469002992 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1245469002993 Walker A/P-loop; other site 1245469002994 ATP binding site [chemical binding]; other site 1245469002995 Q-loop/lid; other site 1245469002996 ABC transporter signature motif; other site 1245469002997 Walker B; other site 1245469002998 D-loop; other site 1245469002999 H-loop/switch region; other site 1245469003000 TOBE domain; Region: TOBE_2; pfam08402 1245469003001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003002 putative PBP binding loops; other site 1245469003003 dimer interface [polypeptide binding]; other site 1245469003004 ABC-ATPase subunit interface; other site 1245469003005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469003006 Bacterial DNA topoisomerase I DNA-binding domain; Region: TOP1Ac; smart00437 1245469003007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003008 ABC-ATPase subunit interface; other site 1245469003009 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1245469003010 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1245469003011 catalytic residues [active] 1245469003012 catalytic nucleophile [active] 1245469003013 Recombinase; Region: Recombinase; pfam07508 1245469003014 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469003015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1245469003016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469003017 Walker A/P-loop; other site 1245469003018 ATP binding site [chemical binding]; other site 1245469003019 Q-loop/lid; other site 1245469003020 ABC transporter signature motif; other site 1245469003021 Walker B; other site 1245469003022 D-loop; other site 1245469003023 H-loop/switch region; other site 1245469003024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003025 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1245469003026 acyl-activating enzyme (AAE) consensus motif; other site 1245469003027 AMP binding site [chemical binding]; other site 1245469003028 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003029 Condensation domain; Region: Condensation; pfam00668 1245469003030 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003032 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003033 acyl-activating enzyme (AAE) consensus motif; other site 1245469003034 AMP binding site [chemical binding]; other site 1245469003035 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003036 Condensation domain; Region: Condensation; pfam00668 1245469003037 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003038 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003039 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003040 acyl-activating enzyme (AAE) consensus motif; other site 1245469003041 AMP binding site [chemical binding]; other site 1245469003042 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003043 Condensation domain; Region: Condensation; pfam00668 1245469003044 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003045 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003046 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003047 acyl-activating enzyme (AAE) consensus motif; other site 1245469003048 AMP binding site [chemical binding]; other site 1245469003049 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003050 Condensation domain; Region: Condensation; pfam00668 1245469003051 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003052 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003053 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003054 acyl-activating enzyme (AAE) consensus motif; other site 1245469003055 AMP binding site [chemical binding]; other site 1245469003056 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003057 Condensation domain; Region: Condensation; pfam00668 1245469003058 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003059 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003060 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003061 acyl-activating enzyme (AAE) consensus motif; other site 1245469003062 AMP binding site [chemical binding]; other site 1245469003063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469003064 S-adenosylmethionine binding site [chemical binding]; other site 1245469003065 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469003066 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003067 Condensation domain; Region: Condensation; pfam00668 1245469003068 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003069 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003070 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003071 acyl-activating enzyme (AAE) consensus motif; other site 1245469003072 AMP binding site [chemical binding]; other site 1245469003073 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003074 Condensation domain; Region: Condensation; pfam00668 1245469003075 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003076 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003077 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003078 acyl-activating enzyme (AAE) consensus motif; other site 1245469003079 AMP binding site [chemical binding]; other site 1245469003080 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003081 Condensation domain; Region: Condensation; pfam00668 1245469003082 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003083 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003084 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003085 acyl-activating enzyme (AAE) consensus motif; other site 1245469003086 AMP binding site [chemical binding]; other site 1245469003087 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003088 Condensation domain; Region: Condensation; pfam00668 1245469003089 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469003090 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003091 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003092 acyl-activating enzyme (AAE) consensus motif; other site 1245469003093 AMP binding site [chemical binding]; other site 1245469003094 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003095 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1245469003096 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469003097 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469003098 acyl-activating enzyme (AAE) consensus motif; other site 1245469003099 AMP binding site [chemical binding]; other site 1245469003100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469003101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469003102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469003103 catalytic residue [active] 1245469003104 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1245469003105 NAD(P) binding site [chemical binding]; other site 1245469003106 catalytic residues [active] 1245469003107 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 1245469003108 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 1245469003109 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1245469003110 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 1245469003111 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1245469003112 Sulfatase; Region: Sulfatase; cl17466 1245469003113 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1245469003114 Substrate binding site [chemical binding]; other site 1245469003115 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1245469003116 Protein of unknown function DUF262; Region: DUF262; pfam03235 1245469003117 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1245469003118 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1245469003119 amphipathic channel; other site 1245469003120 Asn-Pro-Ala signature motifs; other site 1245469003121 Bacterial SH3 domain; Region: SH3_3; cl17532 1245469003122 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1245469003123 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1245469003124 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1245469003125 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1245469003126 MarR family; Region: MarR_2; cl17246 1245469003127 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1245469003128 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469003129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469003130 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1245469003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003132 dimer interface [polypeptide binding]; other site 1245469003133 conserved gate region; other site 1245469003134 putative PBP binding loops; other site 1245469003135 ABC-ATPase subunit interface; other site 1245469003136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469003137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003139 dimer interface [polypeptide binding]; other site 1245469003140 conserved gate region; other site 1245469003141 putative PBP binding loops; other site 1245469003142 ABC-ATPase subunit interface; other site 1245469003143 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469003144 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1245469003145 Walker A/P-loop; other site 1245469003146 ATP binding site [chemical binding]; other site 1245469003147 Q-loop/lid; other site 1245469003148 ABC transporter signature motif; other site 1245469003149 Walker B; other site 1245469003150 D-loop; other site 1245469003151 H-loop/switch region; other site 1245469003152 TOBE domain; Region: TOBE_2; pfam08402 1245469003153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469003154 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469003155 NAD(P) binding site [chemical binding]; other site 1245469003156 active site 1245469003157 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 1245469003158 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 1245469003159 N- and C-terminal domain interface [polypeptide binding]; other site 1245469003160 active site 1245469003161 MgATP binding site [chemical binding]; other site 1245469003162 catalytic site [active] 1245469003163 metal binding site [ion binding]; metal-binding site 1245469003164 carbohydrate binding site [chemical binding]; other site 1245469003165 putative homodimer interface [polypeptide binding]; other site 1245469003166 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1245469003167 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1245469003168 putative substrate binding site [chemical binding]; other site 1245469003169 putative ATP binding site [chemical binding]; other site 1245469003170 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1245469003171 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1245469003172 ligand binding site; other site 1245469003173 oligomer interface; other site 1245469003174 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1245469003175 dimer interface [polypeptide binding]; other site 1245469003176 N-terminal domain interface [polypeptide binding]; other site 1245469003177 sulfate 1 binding site; other site 1245469003178 glycogen synthase; Provisional; Region: PRK14099 1245469003179 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1245469003180 ADP-binding pocket [chemical binding]; other site 1245469003181 homodimer interface [polypeptide binding]; other site 1245469003182 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 1245469003183 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1245469003184 catalytic Zn binding site [ion binding]; other site 1245469003185 structural Zn binding site [ion binding]; other site 1245469003186 NAD(P) binding site [chemical binding]; other site 1245469003187 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1245469003188 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1245469003189 active site 1245469003190 putative substrate binding pocket [chemical binding]; other site 1245469003191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1245469003192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1245469003193 DNA binding site [nucleotide binding] 1245469003194 domain linker motif; other site 1245469003195 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1245469003196 dimerization interface [polypeptide binding]; other site 1245469003197 ligand binding site [chemical binding]; other site 1245469003198 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1245469003199 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1245469003200 active site 1245469003201 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469003202 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469003203 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1245469003204 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469003205 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469003206 active site 1245469003207 catalytic tetrad [active] 1245469003208 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469003209 CoenzymeA binding site [chemical binding]; other site 1245469003210 subunit interaction site [polypeptide binding]; other site 1245469003211 PHB binding site; other site 1245469003212 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1245469003213 putative active site [active] 1245469003214 putative CoA binding site [chemical binding]; other site 1245469003215 nudix motif; other site 1245469003216 metal binding site [ion binding]; metal-binding site 1245469003217 Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; Region: Endostatin-like; cl00181 1245469003218 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1245469003219 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469003220 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 1245469003221 DctM-like transporters; Region: DctM; pfam06808 1245469003222 Domain of unknown function (DUF1850); Region: DUF1850; pfam08905 1245469003223 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1245469003224 classical (c) SDRs; Region: SDR_c; cd05233 1245469003225 NAD(P) binding site [chemical binding]; other site 1245469003226 active site 1245469003227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469003228 TPR motif; other site 1245469003229 TPR repeat; Region: TPR_11; pfam13414 1245469003230 binding surface 1245469003231 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1245469003232 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469003233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469003234 TPR motif; other site 1245469003235 binding surface 1245469003236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469003237 binding surface 1245469003238 TPR motif; other site 1245469003239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469003240 binding surface 1245469003241 TPR motif; other site 1245469003242 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1245469003243 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1245469003244 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1245469003245 acyl-activating enzyme (AAE) consensus motif; other site 1245469003246 putative AMP binding site [chemical binding]; other site 1245469003247 putative active site [active] 1245469003248 putative CoA binding site [chemical binding]; other site 1245469003249 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 1245469003250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3820 1245469003251 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1245469003252 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1245469003253 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1245469003254 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 1245469003255 putative active site [active] 1245469003256 putative substrate binding site [chemical binding]; other site 1245469003257 ATP binding site [chemical binding]; other site 1245469003258 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1245469003259 RNA/DNA hybrid binding site [nucleotide binding]; other site 1245469003260 active site 1245469003261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1245469003262 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 1245469003263 catalytic triad [active] 1245469003264 dimer interface [polypeptide binding]; other site 1245469003265 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1245469003266 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1245469003267 acyl-activating enzyme (AAE) consensus motif; other site 1245469003268 putative AMP binding site [chemical binding]; other site 1245469003269 putative active site [active] 1245469003270 putative CoA binding site [chemical binding]; other site 1245469003271 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1245469003272 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1245469003273 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 1245469003274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469003275 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1245469003276 Walker A/P-loop; other site 1245469003277 ATP binding site [chemical binding]; other site 1245469003278 Q-loop/lid; other site 1245469003279 ABC transporter signature motif; other site 1245469003280 Walker B; other site 1245469003281 D-loop; other site 1245469003282 H-loop/switch region; other site 1245469003283 NMT1/THI5 like; Region: NMT1; pfam09084 1245469003284 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469003285 substrate binding pocket [chemical binding]; other site 1245469003286 membrane-bound complex binding site; other site 1245469003287 hinge residues; other site 1245469003288 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1245469003289 metal binding site [ion binding]; metal-binding site 1245469003290 Predicted membrane protein [Function unknown]; Region: COG1238 1245469003291 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1245469003292 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1245469003293 FMN binding site [chemical binding]; other site 1245469003294 substrate binding site [chemical binding]; other site 1245469003295 putative catalytic residue [active] 1245469003296 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469003297 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469003298 putative ligand binding site [chemical binding]; other site 1245469003299 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469003300 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469003301 putative ligand binding site [chemical binding]; other site 1245469003302 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469003303 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469003304 putative ligand binding site [chemical binding]; other site 1245469003305 septum formation inhibitor; Reviewed; Region: minC; PRK05177 1245469003306 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1245469003307 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1245469003308 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1245469003309 Switch I; other site 1245469003310 Switch II; other site 1245469003311 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1245469003312 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1245469003313 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1245469003314 active site 1 [active] 1245469003315 active site 2 [active] 1245469003316 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469003317 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469003318 dimerization interface [polypeptide binding]; other site 1245469003319 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469003320 dimer interface [polypeptide binding]; other site 1245469003321 putative CheW interface [polypeptide binding]; other site 1245469003322 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1245469003323 acyl-CoA synthetase; Validated; Region: PRK06188 1245469003324 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469003325 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469003326 acyl-activating enzyme (AAE) consensus motif; other site 1245469003327 acyl-activating enzyme (AAE) consensus motif; other site 1245469003328 putative AMP binding site [chemical binding]; other site 1245469003329 putative active site [active] 1245469003330 putative CoA binding site [chemical binding]; other site 1245469003331 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1245469003332 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1245469003333 FMN binding site [chemical binding]; other site 1245469003334 substrate binding site [chemical binding]; other site 1245469003335 putative catalytic residue [active] 1245469003336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469003337 NAD(P) binding site [chemical binding]; other site 1245469003338 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1245469003339 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469003340 active site 1245469003341 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469003342 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469003343 NAD synthetase; Reviewed; Region: nadE; PRK02628 1245469003344 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1245469003345 multimer interface [polypeptide binding]; other site 1245469003346 active site 1245469003347 catalytic triad [active] 1245469003348 protein interface 1 [polypeptide binding]; other site 1245469003349 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1245469003350 homodimer interface [polypeptide binding]; other site 1245469003351 NAD binding pocket [chemical binding]; other site 1245469003352 ATP binding pocket [chemical binding]; other site 1245469003353 Mg binding site [ion binding]; other site 1245469003354 active-site loop [active] 1245469003355 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1245469003356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469003358 putative substrate translocation pore; other site 1245469003359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469003360 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469003361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469003362 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1245469003363 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469003364 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1245469003365 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1245469003366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469003367 ATP binding site [chemical binding]; other site 1245469003368 putative Mg++ binding site [ion binding]; other site 1245469003369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469003370 nucleotide binding region [chemical binding]; other site 1245469003371 ATP-binding site [chemical binding]; other site 1245469003372 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1245469003373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469003374 catalytic loop [active] 1245469003375 iron binding site [ion binding]; other site 1245469003376 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1245469003377 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469003378 catalytic loop [active] 1245469003379 iron binding site [ion binding]; other site 1245469003380 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1245469003381 FAD binding pocket [chemical binding]; other site 1245469003382 conserved FAD binding motif [chemical binding]; other site 1245469003383 phosphate binding motif [ion binding]; other site 1245469003384 beta-alpha-beta structure motif; other site 1245469003385 NAD binding pocket [chemical binding]; other site 1245469003386 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1245469003387 dimerization interface [polypeptide binding]; other site 1245469003388 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1245469003389 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 1245469003390 [2Fe-2S] cluster binding site [ion binding]; other site 1245469003391 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 1245469003392 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1245469003393 dimerization interface [polypeptide binding]; other site 1245469003394 putative path to active site cavity [active] 1245469003395 diiron center [ion binding]; other site 1245469003396 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469003397 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469003398 catalytic loop [active] 1245469003399 iron binding site [ion binding]; other site 1245469003400 short chain dehydrogenase; Provisional; Region: PRK12939 1245469003401 classical (c) SDRs; Region: SDR_c; cd05233 1245469003402 NAD(P) binding site [chemical binding]; other site 1245469003403 active site 1245469003404 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469003405 Zn2+ binding site [ion binding]; other site 1245469003406 Mg2+ binding site [ion binding]; other site 1245469003407 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469003408 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1245469003409 NAD(P) binding site [chemical binding]; other site 1245469003410 catalytic residues [active] 1245469003411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469003412 Zn2+ binding site [ion binding]; other site 1245469003413 Mg2+ binding site [ion binding]; other site 1245469003414 hypothetical protein; Provisional; Region: PRK08296 1245469003415 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1245469003416 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1245469003417 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469003418 Cytochrome P450; Region: p450; cl12078 1245469003419 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1245469003420 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1245469003421 binding surface 1245469003422 TPR motif; other site 1245469003423 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469003424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469003425 hypothetical protein; Reviewed; Region: PRK09588 1245469003426 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1245469003427 RF-1 domain; Region: RF-1; cl17422 1245469003428 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1245469003429 putative chaperone; Provisional; Region: PRK11678 1245469003430 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1245469003431 nucleotide binding site [chemical binding]; other site 1245469003432 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1245469003433 SBD interface [polypeptide binding]; other site 1245469003434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1245469003435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1245469003436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469003437 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1245469003438 DNA binding site [nucleotide binding] 1245469003439 Predicted integral membrane protein [Function unknown]; Region: COG5616 1245469003440 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 1245469003441 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1245469003442 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469003443 putative AMP binding site [chemical binding]; other site 1245469003444 putative active site [active] 1245469003445 acyl-activating enzyme (AAE) consensus motif; other site 1245469003446 putative CoA binding site [chemical binding]; other site 1245469003447 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1245469003448 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469003449 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1245469003450 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1245469003451 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469003452 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469003453 protein binding site [polypeptide binding]; other site 1245469003454 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469003455 Predicted esterase [General function prediction only]; Region: COG0400 1245469003456 Predicted periplasmic protein [Function unknown]; Region: COG3904 1245469003457 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1245469003458 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1245469003459 catalytic residues [active] 1245469003460 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1245469003461 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1245469003462 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1245469003463 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 1245469003464 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1245469003465 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1245469003466 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469003467 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469003468 metal binding site [ion binding]; metal-binding site 1245469003469 active site 1245469003470 I-site; other site 1245469003471 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469003472 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1245469003473 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1245469003474 active site 1245469003475 NHL repeat; Region: NHL; pfam01436 1245469003476 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 1245469003477 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469003478 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1245469003479 endonuclease III; Region: ENDO3c; smart00478 1245469003480 minor groove reading motif; other site 1245469003481 helix-hairpin-helix signature motif; other site 1245469003482 substrate binding pocket [chemical binding]; other site 1245469003483 active site 1245469003484 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1245469003485 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1245469003486 active site 1245469003487 KMSKS motif; other site 1245469003488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469003489 dimer interface [polypeptide binding]; other site 1245469003490 phosphorylation site [posttranslational modification] 1245469003491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469003492 ATP binding site [chemical binding]; other site 1245469003493 Mg2+ binding site [ion binding]; other site 1245469003494 G-X-G motif; other site 1245469003495 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469003496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469003497 active site 1245469003498 phosphorylation site [posttranslational modification] 1245469003499 intermolecular recognition site; other site 1245469003500 dimerization interface [polypeptide binding]; other site 1245469003501 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1245469003502 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 1245469003503 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1245469003504 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1245469003505 Ligand binding site [chemical binding]; other site 1245469003506 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1245469003507 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1245469003508 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1245469003509 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1245469003510 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 1245469003511 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469003512 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469003513 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1245469003514 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1245469003515 catalytic residues [active] 1245469003516 argininosuccinate lyase; Provisional; Region: PRK00855 1245469003517 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1245469003518 active sites [active] 1245469003519 tetramer interface [polypeptide binding]; other site 1245469003520 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1245469003521 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1245469003522 active site 1245469003523 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469003524 substrate binding site [chemical binding]; other site 1245469003525 catalytic residues [active] 1245469003526 dimer interface [polypeptide binding]; other site 1245469003527 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 1245469003528 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1245469003529 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1245469003530 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469003531 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 1245469003532 Protein of unknown function (DUF964); Region: DUF964; cl01483 1245469003533 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1245469003534 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1245469003535 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1245469003536 putative active site [active] 1245469003537 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1245469003538 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1245469003539 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1245469003540 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1245469003541 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1245469003542 active site 1245469003543 metal binding site [ion binding]; metal-binding site 1245469003544 homotetramer interface [polypeptide binding]; other site 1245469003545 transcription elongation factor regulatory protein; Validated; Region: PRK06342 1245469003546 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1245469003547 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1245469003548 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469003549 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469003550 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469003551 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1245469003552 inhibitor site; inhibition site 1245469003553 active site 1245469003554 dimer interface [polypeptide binding]; other site 1245469003555 catalytic residue [active] 1245469003556 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469003557 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469003558 Walker A/P-loop; other site 1245469003559 ATP binding site [chemical binding]; other site 1245469003560 Q-loop/lid; other site 1245469003561 ABC transporter signature motif; other site 1245469003562 Walker B; other site 1245469003563 D-loop; other site 1245469003564 H-loop/switch region; other site 1245469003565 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469003566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003567 dimer interface [polypeptide binding]; other site 1245469003568 conserved gate region; other site 1245469003569 putative PBP binding loops; other site 1245469003570 ABC-ATPase subunit interface; other site 1245469003571 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469003572 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469003573 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469003574 classical (c) SDRs; Region: SDR_c; cd05233 1245469003575 NAD(P) binding site [chemical binding]; other site 1245469003576 active site 1245469003577 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1245469003578 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 1245469003579 putative active site pocket [active] 1245469003580 metal binding site [ion binding]; metal-binding site 1245469003581 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1245469003582 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1245469003583 active site 1245469003584 non-prolyl cis peptide bond; other site 1245469003585 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1245469003586 Na binding site [ion binding]; other site 1245469003587 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1245469003588 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1245469003589 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1245469003590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469003591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469003592 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1245469003593 dimerization interface [polypeptide binding]; other site 1245469003594 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469003595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469003596 active site 1245469003597 phosphorylation site [posttranslational modification] 1245469003598 intermolecular recognition site; other site 1245469003599 dimerization interface [polypeptide binding]; other site 1245469003600 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1245469003601 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1245469003602 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1245469003603 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1245469003604 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469003605 Walker A/P-loop; other site 1245469003606 ATP binding site [chemical binding]; other site 1245469003607 Q-loop/lid; other site 1245469003608 ABC transporter signature motif; other site 1245469003609 Walker B; other site 1245469003610 D-loop; other site 1245469003611 H-loop/switch region; other site 1245469003612 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1245469003613 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1245469003614 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1245469003615 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1245469003616 putative active site [active] 1245469003617 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1245469003618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1245469003619 putative acyl-acceptor binding pocket; other site 1245469003620 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1245469003621 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1245469003622 putative active site pocket [active] 1245469003623 dimerization interface [polypeptide binding]; other site 1245469003624 putative catalytic residue [active] 1245469003625 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 1245469003626 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 1245469003627 prephenate dehydrogenase; Validated; Region: PRK08507 1245469003628 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1245469003629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469003630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469003631 homodimer interface [polypeptide binding]; other site 1245469003632 catalytic residue [active] 1245469003633 hypothetical protein; Provisional; Region: PRK06034 1245469003634 Chorismate mutase type II; Region: CM_2; pfam01817 1245469003635 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1245469003636 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1245469003637 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469003638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469003639 S-adenosylmethionine binding site [chemical binding]; other site 1245469003640 MgtC family; Region: MgtC; pfam02308 1245469003641 Predicted periplasmic protein [Function unknown]; Region: COG3904 1245469003642 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1245469003643 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469003644 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1245469003645 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1245469003646 G1 box; other site 1245469003647 putative GEF interaction site [polypeptide binding]; other site 1245469003648 GTP/Mg2+ binding site [chemical binding]; other site 1245469003649 Switch I region; other site 1245469003650 G2 box; other site 1245469003651 CysD dimerization site [polypeptide binding]; other site 1245469003652 G3 box; other site 1245469003653 Switch II region; other site 1245469003654 G4 box; other site 1245469003655 G5 box; other site 1245469003656 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1245469003657 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1245469003658 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1245469003659 ligand-binding site [chemical binding]; other site 1245469003660 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1245469003661 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1245469003662 Active Sites [active] 1245469003663 siroheme synthase; Provisional; Region: cysG; PRK10637 1245469003664 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1245469003665 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 1245469003666 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1245469003667 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1245469003668 active site 1245469003669 SAM binding site [chemical binding]; other site 1245469003670 homodimer interface [polypeptide binding]; other site 1245469003671 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 1245469003672 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1245469003673 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1245469003674 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1245469003675 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 1245469003676 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1245469003677 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1245469003678 Active Sites [active] 1245469003679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469003680 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1245469003681 substrate binding pocket [chemical binding]; other site 1245469003682 membrane-bound complex binding site; other site 1245469003683 hinge residues; other site 1245469003684 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1245469003685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003686 dimer interface [polypeptide binding]; other site 1245469003687 conserved gate region; other site 1245469003688 putative PBP binding loops; other site 1245469003689 ABC-ATPase subunit interface; other site 1245469003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003691 dimer interface [polypeptide binding]; other site 1245469003692 conserved gate region; other site 1245469003693 putative PBP binding loops; other site 1245469003694 ABC-ATPase subunit interface; other site 1245469003695 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1245469003696 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1245469003697 Walker A/P-loop; other site 1245469003698 ATP binding site [chemical binding]; other site 1245469003699 Q-loop/lid; other site 1245469003700 ABC transporter signature motif; other site 1245469003701 Walker B; other site 1245469003702 D-loop; other site 1245469003703 H-loop/switch region; other site 1245469003704 TOBE-like domain; Region: TOBE_3; pfam12857 1245469003705 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1245469003706 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1245469003707 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1245469003708 active site 1245469003709 nucleophile elbow; other site 1245469003710 Patatin phospholipase; Region: DUF3734; pfam12536 1245469003711 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1245469003712 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1245469003713 NAD binding site [chemical binding]; other site 1245469003714 homotetramer interface [polypeptide binding]; other site 1245469003715 homodimer interface [polypeptide binding]; other site 1245469003716 substrate binding site [chemical binding]; other site 1245469003717 active site 1245469003718 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1245469003719 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1245469003720 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1245469003721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469003722 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469003723 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1245469003724 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1245469003725 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1245469003726 hypothetical protein; Validated; Region: PRK00228 1245469003727 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1245469003728 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1245469003729 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1245469003730 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1245469003731 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1245469003732 classical (c) SDRs; Region: SDR_c; cd05233 1245469003733 NAD(P) binding site [chemical binding]; other site 1245469003734 active site 1245469003735 CsbD-like; Region: CsbD; pfam05532 1245469003736 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1245469003737 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1245469003738 active site 1245469003739 oxyanion hole [active] 1245469003740 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1245469003741 catalytic triad [active] 1245469003742 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1245469003743 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1245469003744 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469003745 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1245469003746 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1245469003747 active site 1245469003748 tetramer interface; other site 1245469003749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469003750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469003751 metal binding site [ion binding]; metal-binding site 1245469003752 active site 1245469003753 I-site; other site 1245469003754 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469003755 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1245469003756 peptide binding site [polypeptide binding]; other site 1245469003757 dimer interface [polypeptide binding]; other site 1245469003758 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469003759 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 1245469003760 peptide binding site [polypeptide binding]; other site 1245469003761 dimer interface [polypeptide binding]; other site 1245469003762 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003764 dimer interface [polypeptide binding]; other site 1245469003765 conserved gate region; other site 1245469003766 putative PBP binding loops; other site 1245469003767 ABC-ATPase subunit interface; other site 1245469003768 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469003769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469003770 dimer interface [polypeptide binding]; other site 1245469003771 conserved gate region; other site 1245469003772 putative PBP binding loops; other site 1245469003773 ABC-ATPase subunit interface; other site 1245469003774 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469003775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469003776 Walker A/P-loop; other site 1245469003777 ATP binding site [chemical binding]; other site 1245469003778 Q-loop/lid; other site 1245469003779 ABC transporter signature motif; other site 1245469003780 Walker B; other site 1245469003781 D-loop; other site 1245469003782 H-loop/switch region; other site 1245469003783 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1245469003784 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1245469003785 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469003786 Walker A/P-loop; other site 1245469003787 ATP binding site [chemical binding]; other site 1245469003788 Q-loop/lid; other site 1245469003789 ABC transporter signature motif; other site 1245469003790 Walker B; other site 1245469003791 D-loop; other site 1245469003792 H-loop/switch region; other site 1245469003793 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1245469003794 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1245469003795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469003796 dimer interface [polypeptide binding]; other site 1245469003797 putative CheW interface [polypeptide binding]; other site 1245469003798 PilZ domain; Region: PilZ; pfam07238 1245469003799 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1245469003800 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1245469003801 acyl-activating enzyme (AAE) consensus motif; other site 1245469003802 putative AMP binding site [chemical binding]; other site 1245469003803 putative active site [active] 1245469003804 putative CoA binding site [chemical binding]; other site 1245469003805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469003806 MarR family; Region: MarR; pfam01047 1245469003807 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 1245469003808 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1245469003809 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469003810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469003811 PAS fold; Region: PAS_3; pfam08447 1245469003812 putative active site [active] 1245469003813 heme pocket [chemical binding]; other site 1245469003814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469003815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469003816 metal binding site [ion binding]; metal-binding site 1245469003817 active site 1245469003818 I-site; other site 1245469003819 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469003820 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1245469003821 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1245469003822 NAD(P) binding site [chemical binding]; other site 1245469003823 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 1245469003824 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 1245469003825 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 1245469003826 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1245469003827 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469003828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469003829 Walker A/P-loop; other site 1245469003830 ATP binding site [chemical binding]; other site 1245469003831 Q-loop/lid; other site 1245469003832 ABC transporter signature motif; other site 1245469003833 Walker B; other site 1245469003834 D-loop; other site 1245469003835 H-loop/switch region; other site 1245469003836 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1245469003837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469003838 Coenzyme A binding pocket [chemical binding]; other site 1245469003839 hypothetical protein; Validated; Region: PRK09039 1245469003840 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469003841 ligand binding site [chemical binding]; other site 1245469003842 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1245469003843 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1245469003844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469003845 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469003846 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1245469003847 Protein export membrane protein; Region: SecD_SecF; cl14618 1245469003848 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1245469003849 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1245469003850 active site 1245469003851 dimerization interface [polypeptide binding]; other site 1245469003852 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469003853 Sel1-like repeats; Region: SEL1; smart00671 1245469003854 Sel1-like repeats; Region: SEL1; smart00671 1245469003855 Sel1-like repeats; Region: SEL1; smart00671 1245469003856 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1245469003857 thiamine phosphate binding site [chemical binding]; other site 1245469003858 active site 1245469003859 pyrophosphate binding site [ion binding]; other site 1245469003860 Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948 1245469003861 active site 1245469003862 intersubunit interface [polypeptide binding]; other site 1245469003863 catalytic residue [active] 1245469003864 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1245469003865 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1245469003866 intersubunit interface [polypeptide binding]; other site 1245469003867 active site 1245469003868 zinc binding site [ion binding]; other site 1245469003869 Na+ binding site [ion binding]; other site 1245469003870 Phosphoglycerate kinase; Region: PGK; pfam00162 1245469003871 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1245469003872 substrate binding site [chemical binding]; other site 1245469003873 hinge regions; other site 1245469003874 ADP binding site [chemical binding]; other site 1245469003875 catalytic site [active] 1245469003876 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1245469003877 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1245469003878 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1245469003879 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1245469003880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469003881 ATP binding site [chemical binding]; other site 1245469003882 putative Mg++ binding site [ion binding]; other site 1245469003883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469003884 nucleotide binding region [chemical binding]; other site 1245469003885 ATP-binding site [chemical binding]; other site 1245469003886 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1245469003887 HRDC domain; Region: HRDC; pfam00570 1245469003888 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1245469003889 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1245469003890 TPP-binding site [chemical binding]; other site 1245469003891 dimer interface [polypeptide binding]; other site 1245469003892 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1245469003893 PYR/PP interface [polypeptide binding]; other site 1245469003894 dimer interface [polypeptide binding]; other site 1245469003895 TPP binding site [chemical binding]; other site 1245469003896 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1245469003897 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 1245469003898 Cell division protein ZapA; Region: ZapA; pfam05164 1245469003899 Predicted ester cyclase [General function prediction only]; Region: COG5485 1245469003900 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469003901 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469003902 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469003903 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1245469003904 putative C-terminal domain interface [polypeptide binding]; other site 1245469003905 putative GSH binding site (G-site) [chemical binding]; other site 1245469003906 putative dimer interface [polypeptide binding]; other site 1245469003907 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469003908 N-terminal domain interface [polypeptide binding]; other site 1245469003909 dimer interface [polypeptide binding]; other site 1245469003910 substrate binding pocket (H-site) [chemical binding]; other site 1245469003911 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469003912 DsrE/DsrF-like family; Region: DrsE; pfam02635 1245469003913 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1245469003914 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1245469003915 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1245469003916 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1245469003917 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469003918 putative active site [active] 1245469003919 metal binding site [ion binding]; metal-binding site 1245469003920 homodimer binding site [polypeptide binding]; other site 1245469003921 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469003922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469003923 dimer interface [polypeptide binding]; other site 1245469003924 putative CheW interface [polypeptide binding]; other site 1245469003925 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469003926 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469003927 dimer interface [polypeptide binding]; other site 1245469003928 putative CheW interface [polypeptide binding]; other site 1245469003929 hypothetical protein; Validated; Region: PRK00110 1245469003930 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1245469003931 active site 1245469003932 putative DNA-binding cleft [nucleotide binding]; other site 1245469003933 dimer interface [polypeptide binding]; other site 1245469003934 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1245469003935 RuvA N terminal domain; Region: RuvA_N; pfam01330 1245469003936 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1245469003937 active site 1245469003938 catalytic motif [active] 1245469003939 Zn binding site [ion binding]; other site 1245469003940 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1245469003941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469003942 Walker A motif; other site 1245469003943 ATP binding site [chemical binding]; other site 1245469003944 Walker B motif; other site 1245469003945 arginine finger; other site 1245469003946 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1245469003947 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1245469003948 nudix motif; other site 1245469003949 phosphodiesterase YaeI; Provisional; Region: PRK11340 1245469003950 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1245469003951 putative active site [active] 1245469003952 putative metal binding site [ion binding]; other site 1245469003953 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1245469003954 active site 1245469003955 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1245469003956 Part of AAA domain; Region: AAA_19; pfam13245 1245469003957 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1245469003958 AAA domain; Region: AAA_12; pfam13087 1245469003959 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1245469003960 putative active site [active] 1245469003961 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1245469003962 glutathionine S-transferase; Provisional; Region: PRK10542 1245469003963 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1245469003964 C-terminal domain interface [polypeptide binding]; other site 1245469003965 GSH binding site (G-site) [chemical binding]; other site 1245469003966 dimer interface [polypeptide binding]; other site 1245469003967 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1245469003968 N-terminal domain interface [polypeptide binding]; other site 1245469003969 dimer interface [polypeptide binding]; other site 1245469003970 substrate binding pocket (H-site) [chemical binding]; other site 1245469003971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469003972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469003973 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1245469003974 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469003975 putative ligand binding site [chemical binding]; other site 1245469003976 NAD binding site [chemical binding]; other site 1245469003977 dimerization interface [polypeptide binding]; other site 1245469003978 catalytic site [active] 1245469003979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1245469003980 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1245469003981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469003982 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1245469003983 DNA binding residues [nucleotide binding] 1245469003984 DoxX-like family; Region: DoxX_2; pfam13564 1245469003985 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1245469003986 dimer interface [polypeptide binding]; other site 1245469003987 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469003988 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469003989 classical (c) SDRs; Region: SDR_c; cd05233 1245469003990 NAD(P) binding site [chemical binding]; other site 1245469003991 active site 1245469003992 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469003993 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1245469003994 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1245469003995 RibD C-terminal domain; Region: RibD_C; cl17279 1245469003996 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469003997 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1245469003998 C-terminal domain interface [polypeptide binding]; other site 1245469003999 GSH binding site (G-site) [chemical binding]; other site 1245469004000 dimer interface [polypeptide binding]; other site 1245469004001 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1245469004002 N-terminal domain interface [polypeptide binding]; other site 1245469004003 dimer interface [polypeptide binding]; other site 1245469004004 substrate binding pocket (H-site) [chemical binding]; other site 1245469004005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1245469004006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1245469004007 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469004008 MarR family; Region: MarR_2; pfam12802 1245469004009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469004010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469004011 WHG domain; Region: WHG; pfam13305 1245469004012 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 1245469004013 TolQ protein; Region: tolQ; TIGR02796 1245469004014 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1245469004015 TolR protein; Region: tolR; TIGR02801 1245469004016 translocation protein TolB; Provisional; Region: tolB; PRK05137 1245469004017 TolB amino-terminal domain; Region: TolB_N; pfam04052 1245469004018 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1245469004019 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1245469004020 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1245469004021 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1245469004022 PAS fold; Region: PAS_7; pfam12860 1245469004023 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469004024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469004025 metal binding site [ion binding]; metal-binding site 1245469004026 active site 1245469004027 I-site; other site 1245469004028 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469004029 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1245469004030 ligand binding site [chemical binding]; other site 1245469004031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004033 binding surface 1245469004034 TPR motif; other site 1245469004035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004037 binding surface 1245469004038 TPR motif; other site 1245469004039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004042 binding surface 1245469004043 TPR motif; other site 1245469004044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004047 binding surface 1245469004048 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004049 TPR motif; other site 1245469004050 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004051 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004052 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004053 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004055 binding surface 1245469004056 TPR motif; other site 1245469004057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004059 binding surface 1245469004060 TPR motif; other site 1245469004061 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004062 CHAT domain; Region: CHAT; pfam12770 1245469004063 Autoinducer synthetase; Region: Autoind_synth; cl17404 1245469004064 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1245469004065 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469004066 ligand binding site [chemical binding]; other site 1245469004067 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1245469004068 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1245469004069 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1245469004070 Ligand Binding Site [chemical binding]; other site 1245469004071 FtsH Extracellular; Region: FtsH_ext; pfam06480 1245469004072 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1245469004073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004074 Walker A motif; other site 1245469004075 ATP binding site [chemical binding]; other site 1245469004076 Walker B motif; other site 1245469004077 arginine finger; other site 1245469004078 Peptidase family M41; Region: Peptidase_M41; pfam01434 1245469004079 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1245469004080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469004081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469004082 pyruvate kinase; Provisional; Region: PRK06247 1245469004083 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1245469004084 domain interfaces; other site 1245469004085 active site 1245469004086 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 1245469004087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3492 1245469004088 hypothetical protein; Provisional; Region: PRK13694 1245469004089 Peptidase M15; Region: Peptidase_M15_3; cl01194 1245469004090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1245469004091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 1245469004092 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469004093 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469004094 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469004095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004096 active site 1245469004097 phosphorylation site [posttranslational modification] 1245469004098 intermolecular recognition site; other site 1245469004099 dimerization interface [polypeptide binding]; other site 1245469004100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004101 Walker A motif; other site 1245469004102 ATP binding site [chemical binding]; other site 1245469004103 Walker B motif; other site 1245469004104 arginine finger; other site 1245469004105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469004106 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1245469004107 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 1245469004108 active site 1245469004109 Zn binding site [ion binding]; other site 1245469004110 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1245469004111 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 1245469004112 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 1245469004113 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1245469004114 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1245469004115 ligand binding site [chemical binding]; other site 1245469004116 homodimer interface [polypeptide binding]; other site 1245469004117 NAD(P) binding site [chemical binding]; other site 1245469004118 trimer interface B [polypeptide binding]; other site 1245469004119 trimer interface A [polypeptide binding]; other site 1245469004120 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1245469004121 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1245469004122 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1245469004123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469004124 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1245469004125 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1245469004126 transmembrane helices; other site 1245469004127 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1245469004128 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1245469004129 Cupin domain; Region: Cupin_2; cl17218 1245469004130 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1245469004131 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1245469004132 ATP-grasp domain; Region: ATP-grasp; pfam02222 1245469004133 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1245469004134 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469004135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469004136 metal binding site [ion binding]; metal-binding site 1245469004137 active site 1245469004138 I-site; other site 1245469004139 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1245469004140 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 1245469004141 Uncharacterized small protein [Function unknown]; Region: COG5570 1245469004142 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1245469004143 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469004144 PAS domain; Region: PAS; smart00091 1245469004145 PAS fold; Region: PAS_7; pfam12860 1245469004146 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469004147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469004148 putative active site [active] 1245469004149 heme pocket [chemical binding]; other site 1245469004150 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469004151 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469004152 metal binding site [ion binding]; metal-binding site 1245469004153 active site 1245469004154 I-site; other site 1245469004155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469004156 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 1245469004157 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1245469004158 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469004159 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1245469004160 Walker A/P-loop; other site 1245469004161 ATP binding site [chemical binding]; other site 1245469004162 Q-loop/lid; other site 1245469004163 ABC transporter signature motif; other site 1245469004164 Walker B; other site 1245469004165 D-loop; other site 1245469004166 H-loop/switch region; other site 1245469004167 TOBE domain; Region: TOBE_2; pfam08402 1245469004168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469004169 dimer interface [polypeptide binding]; other site 1245469004170 conserved gate region; other site 1245469004171 putative PBP binding loops; other site 1245469004172 ABC-ATPase subunit interface; other site 1245469004173 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469004174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469004175 dimer interface [polypeptide binding]; other site 1245469004176 conserved gate region; other site 1245469004177 putative PBP binding loops; other site 1245469004178 ABC-ATPase subunit interface; other site 1245469004179 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469004180 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469004182 dimer interface [polypeptide binding]; other site 1245469004183 conserved gate region; other site 1245469004184 putative PBP binding loops; other site 1245469004185 ABC-ATPase subunit interface; other site 1245469004186 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1245469004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469004188 dimer interface [polypeptide binding]; other site 1245469004189 conserved gate region; other site 1245469004190 putative PBP binding loops; other site 1245469004191 ABC-ATPase subunit interface; other site 1245469004192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469004193 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1245469004194 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1245469004195 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1245469004196 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1245469004197 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1245469004198 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1245469004199 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1245469004200 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1245469004201 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1245469004202 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1245469004203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469004204 FeS/SAM binding site; other site 1245469004205 HemN C-terminal domain; Region: HemN_C; pfam06969 1245469004206 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 1245469004207 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469004208 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469004209 ligand binding site [chemical binding]; other site 1245469004210 flexible hinge region; other site 1245469004211 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469004212 putative switch regulator; other site 1245469004213 non-specific DNA interactions [nucleotide binding]; other site 1245469004214 DNA binding site [nucleotide binding] 1245469004215 sequence specific DNA binding site [nucleotide binding]; other site 1245469004216 putative cAMP binding site [chemical binding]; other site 1245469004217 NnrS protein; Region: NnrS; pfam05940 1245469004218 PAS domain; Region: PAS_9; pfam13426 1245469004219 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1245469004220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469004221 putative active site [active] 1245469004222 heme pocket [chemical binding]; other site 1245469004223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469004224 dimer interface [polypeptide binding]; other site 1245469004225 phosphorylation site [posttranslational modification] 1245469004226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469004227 ATP binding site [chemical binding]; other site 1245469004228 Mg2+ binding site [ion binding]; other site 1245469004229 G-X-G motif; other site 1245469004230 phasin; Region: phasin_2; TIGR01985 1245469004231 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469004232 P-loop; other site 1245469004233 Magnesium ion binding site [ion binding]; other site 1245469004234 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469004235 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1245469004236 dimer interface [polypeptide binding]; other site 1245469004237 active site 1245469004238 catalytic residue [active] 1245469004239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469004240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469004241 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469004242 putative effector binding pocket; other site 1245469004243 dimerization interface [polypeptide binding]; other site 1245469004244 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1245469004245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469004246 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469004247 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469004248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469004249 putative DNA binding site [nucleotide binding]; other site 1245469004250 putative Zn2+ binding site [ion binding]; other site 1245469004251 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469004252 Predicted membrane protein [Function unknown]; Region: COG2259 1245469004253 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1245469004254 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1245469004255 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1245469004256 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1245469004257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469004258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469004259 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1245469004260 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469004261 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469004262 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1245469004263 IMP binding site; other site 1245469004264 dimer interface [polypeptide binding]; other site 1245469004265 interdomain contacts; other site 1245469004266 partial ornithine binding site; other site 1245469004267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469004268 S-adenosylmethionine binding site [chemical binding]; other site 1245469004269 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1245469004270 Ferritin-like domain; Region: Ferritin; pfam00210 1245469004271 dimerization interface [polypeptide binding]; other site 1245469004272 DPS ferroxidase diiron center [ion binding]; other site 1245469004273 ion pore; other site 1245469004274 Predicted transporter component [General function prediction only]; Region: COG2391 1245469004275 Sulphur transport; Region: Sulf_transp; pfam04143 1245469004276 Predicted transporter component [General function prediction only]; Region: COG2391 1245469004277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469004278 dimerization interface [polypeptide binding]; other site 1245469004279 putative DNA binding site [nucleotide binding]; other site 1245469004280 putative Zn2+ binding site [ion binding]; other site 1245469004281 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1245469004282 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1245469004283 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1245469004284 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469004285 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1245469004286 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1245469004287 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1245469004288 catalytic site [active] 1245469004289 subunit interface [polypeptide binding]; other site 1245469004290 Yqey-like protein; Region: YqeY; pfam09424 1245469004291 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1245469004292 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 1245469004293 active site 1245469004294 acyl-activating enzyme (AAE) consensus motif; other site 1245469004295 putative CoA binding site [chemical binding]; other site 1245469004296 AMP binding site [chemical binding]; other site 1245469004297 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1245469004298 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1245469004299 putative hydrophobic ligand binding site [chemical binding]; other site 1245469004300 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1245469004301 putative hydrophobic ligand binding site [chemical binding]; other site 1245469004302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469004303 dimerization interface [polypeptide binding]; other site 1245469004304 putative DNA binding site [nucleotide binding]; other site 1245469004305 putative Zn2+ binding site [ion binding]; other site 1245469004306 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1245469004307 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1245469004308 putative active site [active] 1245469004309 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1245469004310 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 1245469004311 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1245469004312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469004313 DNA-binding site [nucleotide binding]; DNA binding site 1245469004314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469004315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469004316 homodimer interface [polypeptide binding]; other site 1245469004317 catalytic residue [active] 1245469004318 N-formylglutamate amidohydrolase; Region: FGase; cl01522 1245469004319 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1245469004320 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1245469004321 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1245469004322 putative active site pocket [active] 1245469004323 dimerization interface [polypeptide binding]; other site 1245469004324 putative catalytic residue [active] 1245469004325 DNA primase, catalytic core; Region: dnaG; TIGR01391 1245469004326 CHC2 zinc finger; Region: zf-CHC2; cl17510 1245469004327 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1245469004328 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1245469004329 active site 1245469004330 metal binding site [ion binding]; metal-binding site 1245469004331 interdomain interaction site; other site 1245469004332 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1245469004333 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1245469004334 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1245469004335 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1245469004336 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1245469004337 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469004338 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1245469004339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469004340 DNA binding residues [nucleotide binding] 1245469004341 Protein of unknown function (DUF817); Region: DUF817; cl01520 1245469004342 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1245469004343 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1245469004344 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469004345 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469004346 ligand binding site [chemical binding]; other site 1245469004347 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1245469004348 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1245469004349 short chain dehydrogenase; Provisional; Region: PRK05650 1245469004350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469004351 NAD(P) binding site [chemical binding]; other site 1245469004352 active site 1245469004353 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469004354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004355 active site 1245469004356 phosphorylation site [posttranslational modification] 1245469004357 intermolecular recognition site; other site 1245469004358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469004359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469004360 metal binding site [ion binding]; metal-binding site 1245469004361 active site 1245469004362 I-site; other site 1245469004363 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1245469004364 amidase catalytic site [active] 1245469004365 Zn binding residues [ion binding]; other site 1245469004366 substrate binding site [chemical binding]; other site 1245469004367 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1245469004368 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1245469004369 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469004370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469004371 DNA binding residues [nucleotide binding] 1245469004372 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1245469004373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469004374 RNA binding surface [nucleotide binding]; other site 1245469004375 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1245469004376 active site 1245469004377 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1245469004378 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1245469004379 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 1245469004380 5' RNA guide strand anchoring site; other site 1245469004381 active site 1245469004382 SIR2-like domain; Region: SIR2_2; pfam13289 1245469004383 short chain dehydrogenase; Provisional; Region: PRK06500 1245469004384 classical (c) SDRs; Region: SDR_c; cd05233 1245469004385 NAD(P) binding site [chemical binding]; other site 1245469004386 active site 1245469004387 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1245469004388 Moco binding site; other site 1245469004389 metal coordination site [ion binding]; other site 1245469004390 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469004391 Domain of unknown function DUF302; Region: DUF302; pfam03625 1245469004392 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1245469004393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469004394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469004395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004396 DNA binding site [nucleotide binding] 1245469004397 Predicted ATPase [General function prediction only]; Region: COG3903 1245469004398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469004399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004400 TPR motif; other site 1245469004401 binding surface 1245469004402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469004403 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469004404 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469004405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469004406 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469004407 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469004408 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469004409 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1245469004410 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1245469004411 dimerization interface [polypeptide binding]; other site 1245469004412 DPS ferroxidase diiron center [ion binding]; other site 1245469004413 ion pore; other site 1245469004414 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469004415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1245469004416 MOSC domain; Region: MOSC; pfam03473 1245469004417 3-alpha domain; Region: 3-alpha; pfam03475 1245469004418 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1245469004419 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1245469004420 FAD binding pocket [chemical binding]; other site 1245469004421 FAD binding motif [chemical binding]; other site 1245469004422 phosphate binding motif [ion binding]; other site 1245469004423 beta-alpha-beta structure motif; other site 1245469004424 NAD binding pocket [chemical binding]; other site 1245469004425 Heme binding pocket [chemical binding]; other site 1245469004426 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469004427 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469004428 catalytic loop [active] 1245469004429 iron binding site [ion binding]; other site 1245469004430 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469004431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469004432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004433 DNA binding site [nucleotide binding] 1245469004434 Predicted ATPase [General function prediction only]; Region: COG3903 1245469004435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004436 binding surface 1245469004437 TPR motif; other site 1245469004438 Histidine kinase; Region: HisKA_2; pfam07568 1245469004439 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1245469004440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469004441 ATP binding site [chemical binding]; other site 1245469004442 Mg2+ binding site [ion binding]; other site 1245469004443 G-X-G motif; other site 1245469004444 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469004445 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004446 DNA binding site [nucleotide binding] 1245469004447 Predicted ATPase [General function prediction only]; Region: COG3903 1245469004448 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1245469004449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469004450 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1245469004451 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469004452 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469004453 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469004454 substrate binding site [chemical binding]; other site 1245469004455 oxyanion hole (OAH) forming residues; other site 1245469004456 trimer interface [polypeptide binding]; other site 1245469004457 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469004458 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469004459 catalytic loop [active] 1245469004460 iron binding site [ion binding]; other site 1245469004461 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469004462 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469004463 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469004464 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469004465 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469004466 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469004467 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1245469004468 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1245469004469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469004470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004471 DNA binding site [nucleotide binding] 1245469004472 Predicted ATPase [General function prediction only]; Region: COG3903 1245469004473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469004474 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1245469004475 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1245469004476 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1245469004477 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469004478 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1245469004479 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1245469004480 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469004481 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1245469004482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469004483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469004484 Walker A/P-loop; other site 1245469004485 ATP binding site [chemical binding]; other site 1245469004486 Q-loop/lid; other site 1245469004487 ABC transporter signature motif; other site 1245469004488 Walker B; other site 1245469004489 D-loop; other site 1245469004490 H-loop/switch region; other site 1245469004491 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1245469004492 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 1245469004493 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469004494 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469004495 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469004496 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469004497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469004498 catalytic loop [active] 1245469004499 iron binding site [ion binding]; other site 1245469004500 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469004501 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469004502 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1245469004503 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 1245469004504 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469004505 dimer interface [polypeptide binding]; other site 1245469004506 active site 1245469004507 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469004508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004509 active site 1245469004510 phosphorylation site [posttranslational modification] 1245469004511 intermolecular recognition site; other site 1245469004512 dimerization interface [polypeptide binding]; other site 1245469004513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469004514 DNA binding residues [nucleotide binding] 1245469004515 dimerization interface [polypeptide binding]; other site 1245469004516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1245469004517 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1245469004518 ATP binding site [chemical binding]; other site 1245469004519 Mg2+ binding site [ion binding]; other site 1245469004520 G-X-G motif; other site 1245469004521 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 1245469004522 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1245469004523 30S subunit binding site; other site 1245469004524 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1245469004525 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469004526 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469004527 ligand binding site [chemical binding]; other site 1245469004528 flexible hinge region; other site 1245469004529 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469004530 putative switch regulator; other site 1245469004531 non-specific DNA interactions [nucleotide binding]; other site 1245469004532 DNA binding site [nucleotide binding] 1245469004533 sequence specific DNA binding site [nucleotide binding]; other site 1245469004534 putative cAMP binding site [chemical binding]; other site 1245469004535 PAS domain; Region: PAS; smart00091 1245469004536 PAS domain; Region: PAS_9; pfam13426 1245469004537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469004538 Histidine kinase; Region: HisKA_2; pfam07568 1245469004539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469004540 ATP binding site [chemical binding]; other site 1245469004541 Mg2+ binding site [ion binding]; other site 1245469004542 G-X-G motif; other site 1245469004543 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469004544 SseB protein; Region: SseB; cl06279 1245469004545 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1245469004546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004547 Walker A motif; other site 1245469004548 ATP binding site [chemical binding]; other site 1245469004549 Walker B motif; other site 1245469004550 arginine finger; other site 1245469004551 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469004552 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1245469004553 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1245469004554 NAD binding site [chemical binding]; other site 1245469004555 substrate binding site [chemical binding]; other site 1245469004556 catalytic Zn binding site [ion binding]; other site 1245469004557 structural Zn binding site [ion binding]; other site 1245469004558 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 1245469004559 dimerization interface [polypeptide binding]; other site 1245469004560 putative path to active site cavity [active] 1245469004561 diiron center [ion binding]; other site 1245469004562 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1245469004563 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469004564 catalytic loop [active] 1245469004565 iron binding site [ion binding]; other site 1245469004566 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212 1245469004567 FAD binding pocket [chemical binding]; other site 1245469004568 FAD binding motif [chemical binding]; other site 1245469004569 phosphate binding motif [ion binding]; other site 1245469004570 beta-alpha-beta structure motif; other site 1245469004571 NAD binding pocket [chemical binding]; other site 1245469004572 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 1245469004573 dimerization interface [polypeptide binding]; other site 1245469004574 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 1245469004575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1245469004576 active site 1245469004577 Domain of unknown function DUF59; Region: DUF59; cl00941 1245469004578 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1245469004579 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1245469004580 ring oligomerisation interface [polypeptide binding]; other site 1245469004581 ATP/Mg binding site [chemical binding]; other site 1245469004582 stacking interactions; other site 1245469004583 hinge regions; other site 1245469004584 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1245469004585 GAF domain; Region: GAF; pfam01590 1245469004586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004587 Walker A motif; other site 1245469004588 ATP binding site [chemical binding]; other site 1245469004589 Walker B motif; other site 1245469004590 arginine finger; other site 1245469004591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469004592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469004593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004594 DNA binding site [nucleotide binding] 1245469004595 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469004596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004597 binding surface 1245469004598 TPR motif; other site 1245469004599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469004600 binding surface 1245469004601 TPR motif; other site 1245469004602 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004603 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004604 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004605 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004606 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004607 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004608 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469004609 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1245469004610 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1245469004611 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1245469004612 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1245469004613 active site 1245469004614 homodimer interface [polypeptide binding]; other site 1245469004615 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1245469004616 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1245469004617 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469004618 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469004619 Cytochrome P450; Region: p450; cl12078 1245469004620 ParB-like nuclease domain; Region: ParB; smart00470 1245469004621 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1245469004622 putative heme binding pocket [chemical binding]; other site 1245469004623 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1245469004624 catalytic core [active] 1245469004625 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 1245469004626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004627 Walker A motif; other site 1245469004628 ATP binding site [chemical binding]; other site 1245469004629 Walker B motif; other site 1245469004630 arginine finger; other site 1245469004631 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 1245469004632 Gas vesicle protein; Region: Gas_vesicle; pfam00741 1245469004633 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1245469004634 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1245469004635 Gas vesicle protein G; Region: GvpG; pfam05120 1245469004636 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1245469004637 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1245469004638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004639 Walker A motif; other site 1245469004640 ATP binding site [chemical binding]; other site 1245469004641 Walker B motif; other site 1245469004642 arginine finger; other site 1245469004643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469004644 Walker A motif; other site 1245469004645 ATP binding site [chemical binding]; other site 1245469004646 Walker B motif; other site 1245469004647 arginine finger; other site 1245469004648 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1245469004649 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1245469004650 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1245469004651 Gas vesicle protein; Region: Gas_vesicle; cl02954 1245469004652 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1245469004653 Gas vesicle protein K; Region: GvpK; pfam05121 1245469004654 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 1245469004655 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1245469004656 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1245469004657 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469004658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469004659 dimerization interface [polypeptide binding]; other site 1245469004660 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469004661 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469004662 dimer interface [polypeptide binding]; other site 1245469004663 putative CheW interface [polypeptide binding]; other site 1245469004664 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1245469004665 GAF domain; Region: GAF; pfam01590 1245469004666 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469004667 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1245469004668 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469004669 NAD(P) binding site [chemical binding]; other site 1245469004670 catalytic residues [active] 1245469004671 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469004672 PAS fold; Region: PAS_3; pfam08447 1245469004673 putative active site [active] 1245469004674 heme pocket [chemical binding]; other site 1245469004675 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469004676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469004677 dimer interface [polypeptide binding]; other site 1245469004678 putative CheW interface [polypeptide binding]; other site 1245469004679 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1245469004680 iron-sulfur cluster [ion binding]; other site 1245469004681 [2Fe-2S] cluster binding site [ion binding]; other site 1245469004682 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1245469004683 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1245469004684 putative ligand binding site [chemical binding]; other site 1245469004685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469004686 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469004687 TM-ABC transporter signature motif; other site 1245469004688 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469004689 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469004690 Walker A/P-loop; other site 1245469004691 ATP binding site [chemical binding]; other site 1245469004692 Q-loop/lid; other site 1245469004693 ABC transporter signature motif; other site 1245469004694 Walker B; other site 1245469004695 D-loop; other site 1245469004696 H-loop/switch region; other site 1245469004697 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469004698 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1245469004699 N- and C-terminal domain interface [polypeptide binding]; other site 1245469004700 D-xylulose kinase; Region: XylB; TIGR01312 1245469004701 active site 1245469004702 MgATP binding site [chemical binding]; other site 1245469004703 catalytic site [active] 1245469004704 metal binding site [ion binding]; metal-binding site 1245469004705 xylulose binding site [chemical binding]; other site 1245469004706 homodimer interface [polypeptide binding]; other site 1245469004707 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1245469004708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469004709 NAD(P) binding site [chemical binding]; other site 1245469004710 active site 1245469004711 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1245469004712 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1245469004713 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469004714 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1245469004715 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1245469004716 D-glutamate deacylase; Validated; Region: PRK09061 1245469004717 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469004718 active site 1245469004719 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469004720 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1245469004721 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1245469004722 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1245469004723 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469004724 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469004725 metal binding site [ion binding]; metal-binding site 1245469004726 active site 1245469004727 I-site; other site 1245469004728 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1245469004729 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1245469004730 HSP70 interaction site [polypeptide binding]; other site 1245469004731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1245469004732 binding surface 1245469004733 TPR motif; other site 1245469004734 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469004735 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1245469004736 inhibitor site; inhibition site 1245469004737 active site 1245469004738 dimer interface [polypeptide binding]; other site 1245469004739 catalytic residue [active] 1245469004740 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469004741 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469004742 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469004743 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 1245469004744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469004745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469004746 dimer interface [polypeptide binding]; other site 1245469004747 phosphorylation site [posttranslational modification] 1245469004748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469004749 ATP binding site [chemical binding]; other site 1245469004750 G-X-G motif; other site 1245469004751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469004752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004753 active site 1245469004754 phosphorylation site [posttranslational modification] 1245469004755 intermolecular recognition site; other site 1245469004756 dimerization interface [polypeptide binding]; other site 1245469004757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004758 DNA binding site [nucleotide binding] 1245469004759 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469004760 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469004761 Walker A/P-loop; other site 1245469004762 ATP binding site [chemical binding]; other site 1245469004763 Q-loop/lid; other site 1245469004764 ABC transporter signature motif; other site 1245469004765 Walker B; other site 1245469004766 D-loop; other site 1245469004767 H-loop/switch region; other site 1245469004768 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469004770 NMT1-like family; Region: NMT1_2; pfam13379 1245469004771 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469004772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469004773 dimerization interface [polypeptide binding]; other site 1245469004774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469004775 ATP binding site [chemical binding]; other site 1245469004776 Mg2+ binding site [ion binding]; other site 1245469004777 G-X-G motif; other site 1245469004778 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1245469004779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004780 active site 1245469004781 phosphorylation site [posttranslational modification] 1245469004782 intermolecular recognition site; other site 1245469004783 dimerization interface [polypeptide binding]; other site 1245469004784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469004785 DNA binding site [nucleotide binding] 1245469004786 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1245469004787 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1245469004788 Repair protein; Region: Repair_PSII; pfam04536 1245469004789 Repair protein; Region: Repair_PSII; pfam04536 1245469004790 Predicted transcriptional regulator [Transcription]; Region: COG2378 1245469004791 HTH domain; Region: HTH_11; pfam08279 1245469004792 WYL domain; Region: WYL; pfam13280 1245469004793 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469004794 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1245469004795 putative C-terminal domain interface [polypeptide binding]; other site 1245469004796 putative GSH binding site (G-site) [chemical binding]; other site 1245469004797 putative dimer interface [polypeptide binding]; other site 1245469004798 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1245469004799 dimer interface [polypeptide binding]; other site 1245469004800 N-terminal domain interface [polypeptide binding]; other site 1245469004801 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469004802 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1245469004803 benzoate transport; Region: 2A0115; TIGR00895 1245469004804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469004805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469004806 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469004807 hypothetical protein; Provisional; Region: PRK06126 1245469004808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004809 active site 1245469004810 phosphorylation site [posttranslational modification] 1245469004811 intermolecular recognition site; other site 1245469004812 dimerization interface [polypeptide binding]; other site 1245469004813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469004814 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469004815 active site 1245469004816 phosphorylation site [posttranslational modification] 1245469004817 intermolecular recognition site; other site 1245469004818 dimerization interface [polypeptide binding]; other site 1245469004819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469004820 HWE histidine kinase; Region: HWE_HK; smart00911 1245469004821 PRC-barrel domain; Region: PRC; pfam05239 1245469004822 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1245469004823 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1245469004824 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1245469004825 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469004826 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469004827 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469004828 DNA-binding site [nucleotide binding]; DNA binding site 1245469004829 RNA-binding motif; other site 1245469004830 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469004831 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469004832 catalytic loop [active] 1245469004833 iron binding site [ion binding]; other site 1245469004834 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469004835 cyclase homology domain; Region: CHD; cd07302 1245469004836 nucleotidyl binding site; other site 1245469004837 metal binding site [ion binding]; metal-binding site 1245469004838 dimer interface [polypeptide binding]; other site 1245469004839 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1245469004840 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1245469004841 hypothetical protein; Provisional; Region: PRK05415 1245469004842 Domain of unknown function (DUF697); Region: DUF697; cl12064 1245469004843 YcjX-like family, DUF463; Region: DUF463; pfam04317 1245469004844 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1245469004845 short chain dehydrogenase; Provisional; Region: PRK05650 1245469004846 classical (c) SDRs; Region: SDR_c; cd05233 1245469004847 NAD(P) binding site [chemical binding]; other site 1245469004848 active site 1245469004849 MarR family; Region: MarR_2; pfam12802 1245469004850 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469004851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469004852 classical (c) SDRs; Region: SDR_c; cd05233 1245469004853 NAD(P) binding site [chemical binding]; other site 1245469004854 active site 1245469004855 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1245469004856 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1245469004857 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469004858 PYR/PP interface [polypeptide binding]; other site 1245469004859 dimer interface [polypeptide binding]; other site 1245469004860 TPP binding site [chemical binding]; other site 1245469004861 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469004862 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1245469004863 TPP-binding site [chemical binding]; other site 1245469004864 dimer interface [polypeptide binding]; other site 1245469004865 Uncharacterized conserved protein [Function unknown]; Region: COG3777 1245469004866 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1245469004867 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1245469004868 active site 2 [active] 1245469004869 active site 1 [active] 1245469004870 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469004871 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469004872 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469004873 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469004874 active site 1245469004875 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 1245469004876 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 1245469004877 TPP-binding site; other site 1245469004878 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469004879 PYR/PP interface [polypeptide binding]; other site 1245469004880 dimer interface [polypeptide binding]; other site 1245469004881 TPP binding site [chemical binding]; other site 1245469004882 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469004883 Cytochrome P450; Region: p450; cl12078 1245469004884 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469004885 Cytochrome P450; Region: p450; cl12078 1245469004886 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 1245469004887 isovaleryl-CoA dehydrogenase; Region: PLN02519 1245469004888 substrate binding site [chemical binding]; other site 1245469004889 FAD binding site [chemical binding]; other site 1245469004890 catalytic base [active] 1245469004891 Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987 1245469004892 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1245469004893 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 1245469004894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469004895 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469004896 hypothetical protein; Validated; Region: PRK07586 1245469004897 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469004898 PYR/PP interface [polypeptide binding]; other site 1245469004899 dimer interface [polypeptide binding]; other site 1245469004900 TPP binding site [chemical binding]; other site 1245469004901 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1245469004902 TPP-binding site [chemical binding]; other site 1245469004903 dimer interface [polypeptide binding]; other site 1245469004904 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1245469004905 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1245469004906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469004907 putative substrate translocation pore; other site 1245469004908 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1245469004909 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1245469004910 active site 1245469004911 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469004912 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1245469004913 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1245469004914 active site 1245469004915 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1245469004916 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1245469004917 active site 1245469004918 LysR family transcriptional regulator; Provisional; Region: PRK14997 1245469004919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469004920 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 1245469004921 putative effector binding pocket; other site 1245469004922 putative dimerization interface [polypeptide binding]; other site 1245469004923 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1245469004924 YCII-related domain; Region: YCII; cl00999 1245469004925 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1245469004926 ApbE family; Region: ApbE; pfam02424 1245469004927 FMN-binding domain; Region: FMN_bind; pfam04205 1245469004928 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1245469004929 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1245469004930 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1245469004931 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1245469004932 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1245469004933 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1245469004934 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1245469004935 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1245469004936 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1245469004937 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1245469004938 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1245469004939 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1245469004940 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469004941 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469004942 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1245469004943 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1245469004944 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469004945 Walker A motif; other site 1245469004946 ATP binding site [chemical binding]; other site 1245469004947 Walker B motif; other site 1245469004948 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469004949 Sel1-like repeats; Region: SEL1; smart00671 1245469004950 Sel1-like repeats; Region: SEL1; smart00671 1245469004951 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1245469004952 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469004953 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469004954 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469004955 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1245469004956 Part of AAA domain; Region: AAA_19; pfam13245 1245469004957 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1245469004958 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1245469004959 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1245469004960 YciI-like protein; Reviewed; Region: PRK12863 1245469004961 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1245469004962 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1245469004963 ligand binding site [chemical binding]; other site 1245469004964 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469004965 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469004966 TM-ABC transporter signature motif; other site 1245469004967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469004968 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469004969 TM-ABC transporter signature motif; other site 1245469004970 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469004971 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469004972 Walker A/P-loop; other site 1245469004973 ATP binding site [chemical binding]; other site 1245469004974 Q-loop/lid; other site 1245469004975 ABC transporter signature motif; other site 1245469004976 Walker B; other site 1245469004977 D-loop; other site 1245469004978 H-loop/switch region; other site 1245469004979 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469004980 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1245469004981 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469004982 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1245469004983 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1245469004984 dimer interface [polypeptide binding]; other site 1245469004985 active site 1245469004986 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469004987 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469004988 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1245469004989 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1245469004990 active site 1245469004991 dimer interface [polypeptide binding]; other site 1245469004992 metal binding site [ion binding]; metal-binding site 1245469004993 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1245469004994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469004995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469004996 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469004997 putative effector binding pocket; other site 1245469004998 dimerization interface [polypeptide binding]; other site 1245469004999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469005000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469005001 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469005002 putative effector binding pocket; other site 1245469005003 dimerization interface [polypeptide binding]; other site 1245469005004 TIGR04255 family protein; Region: sporadTIGR04255 1245469005005 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1245469005006 active site 1245469005007 catalytic residues [active] 1245469005008 DNA binding site [nucleotide binding] 1245469005009 Int/Topo IB signature motif; other site 1245469005010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1245469005011 DNA polymerase III subunit beta; Validated; Region: PRK05643 1245469005012 putative DNA binding surface [nucleotide binding]; other site 1245469005013 dimer interface [polypeptide binding]; other site 1245469005014 beta-clamp/translesion DNA polymerase binding surface; other site 1245469005015 beta-clamp/clamp loader binding surface; other site 1245469005016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469005017 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469005018 non-specific DNA binding site [nucleotide binding]; other site 1245469005019 salt bridge; other site 1245469005020 sequence-specific DNA binding site [nucleotide binding]; other site 1245469005021 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1245469005022 Catalytic site [active] 1245469005023 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1245469005024 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469005025 DNA binding site [nucleotide binding] 1245469005026 AAA domain; Region: AAA_24; pfam13479 1245469005027 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1245469005028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469005029 ATP binding site [chemical binding]; other site 1245469005030 putative Mg++ binding site [ion binding]; other site 1245469005031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469005032 nucleotide binding region [chemical binding]; other site 1245469005033 ATP-binding site [chemical binding]; other site 1245469005034 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1245469005035 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1245469005036 polymerase nucleotide-binding site; other site 1245469005037 DNA-binding residues [nucleotide binding]; DNA binding site 1245469005038 nucleotide binding site [chemical binding]; other site 1245469005039 primase nucleotide-binding site [nucleotide binding]; other site 1245469005040 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1245469005041 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469005042 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469005043 catalytic residue [active] 1245469005044 HNH endonuclease; Region: HNH_3; pfam13392 1245469005045 VRR-NUC domain; Region: VRR_NUC; cl17748 1245469005046 Antirestriction protein (ArdA); Region: ArdA; cl01953 1245469005047 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1245469005048 active site 1245469005049 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1245469005050 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1245469005051 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1245469005052 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1245469005053 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 1245469005054 tandem repeat interface [polypeptide binding]; other site 1245469005055 oligomer interface [polypeptide binding]; other site 1245469005056 active site residues [active] 1245469005057 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 1245469005058 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 1245469005059 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 1245469005060 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1245469005061 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1245469005062 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1245469005063 Baseplate J-like protein; Region: Baseplate_J; cl01294 1245469005064 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 1245469005065 membrane glycoprotein; Provisional; Region: PHA03332 1245469005066 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1245469005067 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1245469005068 Phage tail tube protein FII; Region: Phage_tube; pfam04985 1245469005069 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1245469005070 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1245469005071 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1245469005072 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1245469005073 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1245469005074 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1245469005075 amidase catalytic site [active] 1245469005076 Zn binding residues [ion binding]; other site 1245469005077 substrate binding site [chemical binding]; other site 1245469005078 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1245469005079 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 1245469005080 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1245469005081 active site 1245469005082 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 1245469005083 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1245469005084 putative binding surface; other site 1245469005085 active site 1245469005086 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1245469005087 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1245469005088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469005089 ATP binding site [chemical binding]; other site 1245469005090 Mg2+ binding site [ion binding]; other site 1245469005091 G-X-G motif; other site 1245469005092 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1245469005093 CheW-like domain; Region: CheW; pfam01584 1245469005094 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469005095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005096 active site 1245469005097 phosphorylation site [posttranslational modification] 1245469005098 intermolecular recognition site; other site 1245469005099 dimerization interface [polypeptide binding]; other site 1245469005100 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1245469005101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005102 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469005103 active site 1245469005104 phosphorylation site [posttranslational modification] 1245469005105 intermolecular recognition site; other site 1245469005106 dimerization interface [polypeptide binding]; other site 1245469005107 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1245469005108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005109 active site 1245469005110 phosphorylation site [posttranslational modification] 1245469005111 intermolecular recognition site; other site 1245469005112 dimerization interface [polypeptide binding]; other site 1245469005113 CheB methylesterase; Region: CheB_methylest; pfam01339 1245469005114 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1245469005115 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1245469005116 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1245469005117 circadian clock protein KaiC; Reviewed; Region: PRK09302 1245469005118 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469005119 Walker A motif; other site 1245469005120 ATP binding site [chemical binding]; other site 1245469005121 Walker B motif; other site 1245469005122 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469005123 Walker A motif; other site 1245469005124 ATP binding site [chemical binding]; other site 1245469005125 Walker B motif; other site 1245469005126 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1245469005127 tetramer interface [polypeptide binding]; other site 1245469005128 dimer interface [polypeptide binding]; other site 1245469005129 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469005130 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469005131 putative active site [active] 1245469005132 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469005133 putative active site [active] 1245469005134 heme pocket [chemical binding]; other site 1245469005135 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469005136 HWE histidine kinase; Region: HWE_HK; pfam07536 1245469005137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1245469005138 active site 1245469005139 phosphorylation site [posttranslational modification] 1245469005140 intermolecular recognition site; other site 1245469005141 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1245469005142 Predicted membrane protein [Function unknown]; Region: COG3766 1245469005143 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469005144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469005145 DNA-binding site [nucleotide binding]; DNA binding site 1245469005146 FCD domain; Region: FCD; pfam07729 1245469005147 NMT1-like family; Region: NMT1_2; pfam13379 1245469005148 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469005149 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469005150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469005151 dimer interface [polypeptide binding]; other site 1245469005152 conserved gate region; other site 1245469005153 putative PBP binding loops; other site 1245469005154 ABC-ATPase subunit interface; other site 1245469005155 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469005156 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469005157 Walker A/P-loop; other site 1245469005158 ATP binding site [chemical binding]; other site 1245469005159 Q-loop/lid; other site 1245469005160 ABC transporter signature motif; other site 1245469005161 Walker B; other site 1245469005162 D-loop; other site 1245469005163 H-loop/switch region; other site 1245469005164 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1245469005165 dihydropyrimidinase; Provisional; Region: PRK13404 1245469005166 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1245469005167 tetramer interface [polypeptide binding]; other site 1245469005168 active site 1245469005169 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1245469005170 PLD-like domain; Region: PLDc_2; pfam13091 1245469005171 putative active site [active] 1245469005172 catalytic site [active] 1245469005173 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 1245469005174 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1245469005175 putative active site [active] 1245469005176 catalytic site [active] 1245469005177 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469005178 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469005179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005180 active site 1245469005181 phosphorylation site [posttranslational modification] 1245469005182 intermolecular recognition site; other site 1245469005183 dimerization interface [polypeptide binding]; other site 1245469005184 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469005185 DNA binding site [nucleotide binding] 1245469005186 flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927 1245469005187 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1245469005188 Walker A motif/ATP binding site; other site 1245469005189 Walker B motif; other site 1245469005190 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1245469005191 RNA polymerase sigma factor; Provisional; Region: PRK12514 1245469005192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469005193 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1245469005194 DNA binding residues [nucleotide binding] 1245469005195 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1245469005196 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1245469005197 FHIPEP family; Region: FHIPEP; pfam00771 1245469005198 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469005199 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1245469005200 substrate binding pocket [chemical binding]; other site 1245469005201 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469005202 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1245469005203 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469005204 putative NAD(P) binding site [chemical binding]; other site 1245469005205 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1245469005206 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1245469005207 DNA binding residues [nucleotide binding] 1245469005208 putative dimer interface [polypeptide binding]; other site 1245469005209 Putative esterase; Region: Esterase; pfam00756 1245469005210 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1245469005211 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1245469005212 C-terminal domain interface [polypeptide binding]; other site 1245469005213 GSH binding site (G-site) [chemical binding]; other site 1245469005214 putative dimer interface [polypeptide binding]; other site 1245469005215 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469005216 N-terminal domain interface [polypeptide binding]; other site 1245469005217 dimer interface [polypeptide binding]; other site 1245469005218 substrate binding pocket (H-site) [chemical binding]; other site 1245469005219 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469005220 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469005221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469005222 binding surface 1245469005223 TPR motif; other site 1245469005224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469005225 TPR motif; other site 1245469005226 binding surface 1245469005227 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469005228 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469005229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469005230 dimer interface [polypeptide binding]; other site 1245469005231 putative CheW interface [polypeptide binding]; other site 1245469005232 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1245469005233 active site 1 [active] 1245469005234 dimer interface [polypeptide binding]; other site 1245469005235 hexamer interface [polypeptide binding]; other site 1245469005236 active site 2 [active] 1245469005237 short chain dehydrogenase; Provisional; Region: PRK12937 1245469005238 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1245469005239 NADP binding site [chemical binding]; other site 1245469005240 homodimer interface [polypeptide binding]; other site 1245469005241 active site 1245469005242 substrate binding site [chemical binding]; other site 1245469005243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469005244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469005245 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1245469005246 putative effector binding pocket; other site 1245469005247 putative dimerization interface [polypeptide binding]; other site 1245469005248 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 1245469005249 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 1245469005250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469005251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469005252 putative substrate translocation pore; other site 1245469005253 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469005254 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469005255 kynureninase; Region: kynureninase; TIGR01814 1245469005256 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469005257 catalytic residue [active] 1245469005258 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1245469005259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469005260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469005261 dimerization interface [polypeptide binding]; other site 1245469005262 putative DNA binding site [nucleotide binding]; other site 1245469005263 putative Zn2+ binding site [ion binding]; other site 1245469005264 threonine dehydratase; Provisional; Region: PRK08246 1245469005265 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1245469005266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469005267 catalytic residue [active] 1245469005268 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1245469005269 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1245469005270 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1245469005271 homotrimer interaction site [polypeptide binding]; other site 1245469005272 putative active site [active] 1245469005273 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469005274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469005275 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1245469005276 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1245469005277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469005278 dimer interface [polypeptide binding]; other site 1245469005279 conserved gate region; other site 1245469005280 putative PBP binding loops; other site 1245469005281 ABC-ATPase subunit interface; other site 1245469005282 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1245469005283 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1245469005284 Walker A/P-loop; other site 1245469005285 ATP binding site [chemical binding]; other site 1245469005286 Q-loop/lid; other site 1245469005287 ABC transporter signature motif; other site 1245469005288 Walker B; other site 1245469005289 D-loop; other site 1245469005290 H-loop/switch region; other site 1245469005291 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469005292 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469005293 substrate binding pocket [chemical binding]; other site 1245469005294 membrane-bound complex binding site; other site 1245469005295 hinge residues; other site 1245469005296 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469005297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469005298 dimer interface [polypeptide binding]; other site 1245469005299 conserved gate region; other site 1245469005300 putative PBP binding loops; other site 1245469005301 ABC-ATPase subunit interface; other site 1245469005302 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469005303 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469005304 Walker A/P-loop; other site 1245469005305 ATP binding site [chemical binding]; other site 1245469005306 Q-loop/lid; other site 1245469005307 ABC transporter signature motif; other site 1245469005308 Walker B; other site 1245469005309 D-loop; other site 1245469005310 H-loop/switch region; other site 1245469005311 TOBE domain; Region: TOBE_2; pfam08402 1245469005312 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1245469005313 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469005314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469005315 dimer interface [polypeptide binding]; other site 1245469005316 conserved gate region; other site 1245469005317 putative PBP binding loops; other site 1245469005318 ABC-ATPase subunit interface; other site 1245469005319 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469005320 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469005321 active site 1245469005322 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1245469005323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469005324 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1245469005325 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1245469005326 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469005327 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469005328 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469005329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469005330 Walker A/P-loop; other site 1245469005331 ATP binding site [chemical binding]; other site 1245469005332 Q-loop/lid; other site 1245469005333 ABC transporter signature motif; other site 1245469005334 Walker B; other site 1245469005335 D-loop; other site 1245469005336 H-loop/switch region; other site 1245469005337 TOBE domain; Region: TOBE_2; pfam08402 1245469005338 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469005339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469005340 dimer interface [polypeptide binding]; other site 1245469005341 conserved gate region; other site 1245469005342 putative PBP binding loops; other site 1245469005343 ABC-ATPase subunit interface; other site 1245469005344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469005345 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469005346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469005347 putative PBP binding loops; other site 1245469005348 dimer interface [polypeptide binding]; other site 1245469005349 ABC-ATPase subunit interface; other site 1245469005350 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1245469005351 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469005352 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1245469005353 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469005354 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469005355 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1245469005356 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469005357 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1245469005358 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1245469005359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469005360 DNA-binding site [nucleotide binding]; DNA binding site 1245469005361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469005362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469005363 homodimer interface [polypeptide binding]; other site 1245469005364 catalytic residue [active] 1245469005365 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1245469005366 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 1245469005367 Zn binding site [ion binding]; other site 1245469005368 Patatin-like phospholipase; Region: Patatin; pfam01734 1245469005369 active site 1245469005370 nucleophile elbow; other site 1245469005371 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1245469005372 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1245469005373 intersubunit interface [polypeptide binding]; other site 1245469005374 active site 1245469005375 Zn2+ binding site [ion binding]; other site 1245469005376 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1245469005377 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1245469005378 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1245469005379 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1245469005380 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469005381 NAD(P) binding site [chemical binding]; other site 1245469005382 catalytic residues [active] 1245469005383 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1245469005384 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1245469005385 active site 1245469005386 tetramer interface [polypeptide binding]; other site 1245469005387 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469005388 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1245469005389 putative active site [active] 1245469005390 catalytic residue [active] 1245469005391 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1245469005392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469005393 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 1245469005394 putative dimerization interface [polypeptide binding]; other site 1245469005395 putative substrate binding pocket [chemical binding]; other site 1245469005396 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 1245469005397 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1245469005398 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1245469005399 active site 1245469005400 DNA binding site [nucleotide binding] 1245469005401 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1245469005402 DNA binding site [nucleotide binding] 1245469005403 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 1245469005404 nucleotide binding site [chemical binding]; other site 1245469005405 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 1245469005406 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1245469005407 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1245469005408 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1245469005409 active site 1245469005410 catalytic site [active] 1245469005411 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1245469005412 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1245469005413 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1245469005414 catalytic site [active] 1245469005415 active site 1245469005416 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1245469005417 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1245469005418 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1245469005419 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1245469005420 active site 1245469005421 catalytic site [active] 1245469005422 glycogen branching enzyme; Provisional; Region: PRK05402 1245469005423 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1245469005424 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1245469005425 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1245469005426 active site 1245469005427 catalytic site [active] 1245469005428 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1245469005429 trehalose synthase; Region: treS_nterm; TIGR02456 1245469005430 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1245469005431 active site 1245469005432 catalytic site [active] 1245469005433 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1245469005434 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1245469005435 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1245469005436 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1245469005437 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1245469005438 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1245469005439 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1245469005440 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1245469005441 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1245469005442 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1245469005443 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1245469005444 putative active site [active] 1245469005445 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1245469005446 AAA domain; Region: AAA_33; pfam13671 1245469005447 ATP-binding site [chemical binding]; other site 1245469005448 Gluconate-6-phosphate binding site [chemical binding]; other site 1245469005449 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1245469005450 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1245469005451 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1245469005452 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469005453 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1245469005454 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1245469005455 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1245469005456 putative active site [active] 1245469005457 catalytic residue [active] 1245469005458 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1245469005459 active site 1245469005460 dimer interface [polypeptide binding]; other site 1245469005461 SIS_TAL_PGI: Transaldolase (TAL)/ Phosphoglucose isomerase (PGI). This group represents the SIS (Sugar ISomerase) PGI domain, of a multifunctional protein (TAL-PGI ) having both TAL and PGI activities. TAL_PGI contains an N-terminal TAL domain and a...; Region: SIS_TAL_PGI; cd05798 1245469005462 PrkA family serine protein kinase; Provisional; Region: PRK15455 1245469005463 AAA ATPase domain; Region: AAA_16; pfam13191 1245469005464 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1245469005465 hypothetical protein; Provisional; Region: PRK05325 1245469005466 SpoVR family protein; Provisional; Region: PRK11767 1245469005467 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1245469005468 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 1245469005469 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 1245469005470 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1245469005471 TPP-binding site [chemical binding]; other site 1245469005472 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1245469005473 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1245469005474 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1245469005475 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1245469005476 dimer interface [polypeptide binding]; other site 1245469005477 PYR/PP interface [polypeptide binding]; other site 1245469005478 TPP binding site [chemical binding]; other site 1245469005479 substrate binding site [chemical binding]; other site 1245469005480 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1245469005481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469005482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469005483 4Fe-4S binding domain; Region: Fer4; pfam00037 1245469005484 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 1245469005485 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1245469005486 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 1245469005487 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469005488 FeS/SAM binding site; other site 1245469005489 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1245469005490 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 1245469005491 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 1245469005492 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 1245469005493 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 1245469005494 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1245469005495 apolar tunnel; other site 1245469005496 heme binding site [chemical binding]; other site 1245469005497 dimerization interface [polypeptide binding]; other site 1245469005498 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1245469005499 amidase; Provisional; Region: PRK07487 1245469005500 Amidase; Region: Amidase; cl11426 1245469005501 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1245469005502 catalytic residues [active] 1245469005503 dimer interface [polypeptide binding]; other site 1245469005504 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 1245469005505 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 1245469005506 putative hydrophobic ligand binding site [chemical binding]; other site 1245469005507 LrgA family; Region: LrgA; pfam03788 1245469005508 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1245469005509 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1245469005510 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469005511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469005512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469005513 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469005514 putative substrate translocation pore; other site 1245469005515 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469005516 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1245469005517 substrate binding pocket [chemical binding]; other site 1245469005518 membrane-bound complex binding site; other site 1245469005519 hinge residues; other site 1245469005520 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 1245469005521 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1245469005522 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469005523 substrate binding pocket [chemical binding]; other site 1245469005524 membrane-bound complex binding site; other site 1245469005525 hinge residues; other site 1245469005526 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1245469005527 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469005528 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1245469005529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469005530 Cupin domain; Region: Cupin_2; pfam07883 1245469005531 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469005532 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 1245469005533 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1245469005534 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1245469005535 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469005536 putative C-terminal domain interface [polypeptide binding]; other site 1245469005537 putative GSH binding site (G-site) [chemical binding]; other site 1245469005538 putative dimer interface [polypeptide binding]; other site 1245469005539 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1245469005540 putative N-terminal domain interface [polypeptide binding]; other site 1245469005541 putative dimer interface [polypeptide binding]; other site 1245469005542 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469005543 Cupin domain; Region: Cupin_2; cl17218 1245469005544 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1245469005545 Strictosidine synthase; Region: Str_synth; pfam03088 1245469005546 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1245469005547 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469005548 choline dehydrogenase; Validated; Region: PRK02106 1245469005549 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469005550 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1245469005551 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1245469005552 putative ligand binding site [chemical binding]; other site 1245469005553 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469005554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469005555 DNA binding residues [nucleotide binding] 1245469005556 dimerization interface [polypeptide binding]; other site 1245469005557 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469005558 Cytochrome P450; Region: p450; cl12078 1245469005559 PAS domain; Region: PAS_9; pfam13426 1245469005560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469005561 PAS domain; Region: PAS_9; pfam13426 1245469005562 putative active site [active] 1245469005563 heme pocket [chemical binding]; other site 1245469005564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469005565 PAS domain; Region: PAS_9; pfam13426 1245469005566 putative active site [active] 1245469005567 heme pocket [chemical binding]; other site 1245469005568 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469005569 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469005570 dimer interface [polypeptide binding]; other site 1245469005571 putative CheW interface [polypeptide binding]; other site 1245469005572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469005573 PAS domain; Region: PAS_9; pfam13426 1245469005574 putative active site [active] 1245469005575 heme pocket [chemical binding]; other site 1245469005576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469005577 PAS fold; Region: PAS_3; pfam08447 1245469005578 putative active site [active] 1245469005579 heme pocket [chemical binding]; other site 1245469005580 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469005581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469005582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469005583 dimer interface [polypeptide binding]; other site 1245469005584 phosphorylation site [posttranslational modification] 1245469005585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469005586 ATP binding site [chemical binding]; other site 1245469005587 Mg2+ binding site [ion binding]; other site 1245469005588 G-X-G motif; other site 1245469005589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469005590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005591 active site 1245469005592 phosphorylation site [posttranslational modification] 1245469005593 intermolecular recognition site; other site 1245469005594 dimerization interface [polypeptide binding]; other site 1245469005595 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1245469005596 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1245469005597 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1245469005598 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1245469005599 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1245469005600 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469005601 Walker A motif; other site 1245469005602 ATP binding site [chemical binding]; other site 1245469005603 Walker B motif; other site 1245469005604 response regulator; Provisional; Region: PRK13435 1245469005605 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1245469005606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469005607 Walker A motif; other site 1245469005608 ATP binding site [chemical binding]; other site 1245469005609 Walker B motif; other site 1245469005610 arginine finger; other site 1245469005611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1245469005612 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1245469005613 active site residue [active] 1245469005614 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1245469005615 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1245469005616 active site residue [active] 1245469005617 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1245469005618 active site residue [active] 1245469005619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469005620 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469005621 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1245469005622 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469005623 dimerization interface [polypeptide binding]; other site 1245469005624 NAD binding site [chemical binding]; other site 1245469005625 ligand binding site [chemical binding]; other site 1245469005626 catalytic site [active] 1245469005627 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1245469005628 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469005629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469005630 Walker A/P-loop; other site 1245469005631 ATP binding site [chemical binding]; other site 1245469005632 Q-loop/lid; other site 1245469005633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469005634 ABC transporter signature motif; other site 1245469005635 ABC transporter; Region: ABC_tran_2; pfam12848 1245469005636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469005637 hypothetical protein; Provisional; Region: PRK05208 1245469005638 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1245469005639 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1245469005640 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469005641 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1245469005642 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1245469005643 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1245469005644 heme binding site [chemical binding]; other site 1245469005645 ferroxidase pore; other site 1245469005646 ferroxidase diiron center [ion binding]; other site 1245469005647 Protein of unknown function (DUF3240); Region: DUF3240; pfam11582 1245469005648 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1245469005649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469005650 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1245469005651 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469005652 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1245469005653 Predicted membrane protein [Function unknown]; Region: COG4270 1245469005654 hypothetical protein; Provisional; Region: PRK06489 1245469005655 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469005656 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1245469005657 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469005658 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1245469005659 active site 1245469005660 SUMO-1 interface [polypeptide binding]; other site 1245469005661 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1245469005662 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469005663 putative C-terminal domain interface [polypeptide binding]; other site 1245469005664 putative GSH binding site (G-site) [chemical binding]; other site 1245469005665 putative dimer interface [polypeptide binding]; other site 1245469005666 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 1245469005667 putative N-terminal domain interface [polypeptide binding]; other site 1245469005668 putative dimer interface [polypeptide binding]; other site 1245469005669 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469005670 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469005671 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1245469005672 homotrimer interaction site [polypeptide binding]; other site 1245469005673 putative active site [active] 1245469005674 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1245469005675 ThiC-associated domain; Region: ThiC-associated; pfam13667 1245469005676 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1245469005677 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1245469005678 thiamine phosphate binding site [chemical binding]; other site 1245469005679 active site 1245469005680 pyrophosphate binding site [ion binding]; other site 1245469005681 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1245469005682 ThiS interaction site; other site 1245469005683 putative active site [active] 1245469005684 tetramer interface [polypeptide binding]; other site 1245469005685 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1245469005686 thiS-thiF/thiG interaction site; other site 1245469005687 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1245469005688 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469005689 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1245469005690 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469005691 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469005692 catalytic residue [active] 1245469005693 PRC-barrel domain; Region: PRC; pfam05239 1245469005694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469005695 dimerization interface [polypeptide binding]; other site 1245469005696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469005697 dimer interface [polypeptide binding]; other site 1245469005698 phosphorylation site [posttranslational modification] 1245469005699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469005700 ATP binding site [chemical binding]; other site 1245469005701 Mg2+ binding site [ion binding]; other site 1245469005702 G-X-G motif; other site 1245469005703 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1245469005704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005705 active site 1245469005706 phosphorylation site [posttranslational modification] 1245469005707 intermolecular recognition site; other site 1245469005708 dimerization interface [polypeptide binding]; other site 1245469005709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469005710 DNA binding site [nucleotide binding] 1245469005711 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469005712 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469005713 putative ligand binding site [chemical binding]; other site 1245469005714 Domain of unknown function (DUF4403); Region: DUF4403; pfam14356 1245469005715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469005716 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469005717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469005718 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1245469005719 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1245469005720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469005721 S-adenosylmethionine binding site [chemical binding]; other site 1245469005722 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1245469005723 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469005724 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469005725 catalytic residue [active] 1245469005726 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1245469005727 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1245469005728 active site 1245469005729 Ap6A binding site [chemical binding]; other site 1245469005730 nudix motif; other site 1245469005731 metal binding site [ion binding]; metal-binding site 1245469005732 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469005733 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1245469005734 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469005735 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469005736 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1245469005737 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469005738 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469005739 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469005740 EamA-like transporter family; Region: EamA; pfam00892 1245469005741 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1245469005742 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1245469005743 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469005744 Walker A/P-loop; other site 1245469005745 ATP binding site [chemical binding]; other site 1245469005746 Q-loop/lid; other site 1245469005747 ABC transporter signature motif; other site 1245469005748 Walker B; other site 1245469005749 D-loop; other site 1245469005750 H-loop/switch region; other site 1245469005751 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1245469005752 FtsX-like permease family; Region: FtsX; pfam02687 1245469005753 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1245469005754 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469005755 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469005756 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1245469005757 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1245469005758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469005759 active site 1245469005760 phosphorylation site [posttranslational modification] 1245469005761 intermolecular recognition site; other site 1245469005762 dimerization interface [polypeptide binding]; other site 1245469005763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469005764 DNA binding site [nucleotide binding] 1245469005765 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1245469005766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469005767 ATP binding site [chemical binding]; other site 1245469005768 Mg2+ binding site [ion binding]; other site 1245469005769 G-X-G motif; other site 1245469005770 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469005771 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1245469005772 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1245469005773 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1245469005774 nickel responsive regulator; Provisional; Region: PRK02967 1245469005775 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1245469005776 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1245469005777 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1245469005778 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1245469005779 putative trimer interface [polypeptide binding]; other site 1245469005780 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1245469005781 putative CoA binding site [chemical binding]; other site 1245469005782 trimer interface [polypeptide binding]; other site 1245469005783 active site 1245469005784 UDP-GlcNAc binding site [chemical binding]; other site 1245469005785 lipid binding site [chemical binding]; lipid-binding site 1245469005786 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1245469005787 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1245469005788 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1245469005789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469005790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469005791 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1245469005792 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1245469005793 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469005794 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469005795 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1245469005796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469005797 putative substrate translocation pore; other site 1245469005798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469005799 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1245469005800 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1245469005801 Walker A/P-loop; other site 1245469005802 ATP binding site [chemical binding]; other site 1245469005803 Q-loop/lid; other site 1245469005804 ABC transporter signature motif; other site 1245469005805 Walker B; other site 1245469005806 D-loop; other site 1245469005807 H-loop/switch region; other site 1245469005808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1245469005809 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1245469005810 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1245469005811 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1245469005812 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1245469005813 amidase catalytic site [active] 1245469005814 Zn binding residues [ion binding]; other site 1245469005815 substrate binding site [chemical binding]; other site 1245469005816 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469005817 MraW methylase family; Region: Methyltransf_5; cl17771 1245469005818 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1245469005819 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 1245469005820 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1245469005821 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1245469005822 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1245469005823 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1245469005824 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1245469005825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1245469005826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1245469005827 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1245469005828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1245469005829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1245469005830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1245469005831 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1245469005832 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1245469005833 Mg++ binding site [ion binding]; other site 1245469005834 putative catalytic motif [active] 1245469005835 putative substrate binding site [chemical binding]; other site 1245469005836 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1245469005837 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469005838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1245469005839 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1245469005840 cell division protein FtsW; Region: ftsW; TIGR02614 1245469005841 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1245469005842 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1245469005843 active site 1245469005844 homodimer interface [polypeptide binding]; other site 1245469005845 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1245469005846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1245469005847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1245469005848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1245469005849 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1245469005850 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469005851 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1245469005852 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1245469005853 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1245469005854 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469005855 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1245469005856 Cell division protein FtsQ; Region: FtsQ; pfam03799 1245469005857 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1245469005858 Cell division protein FtsA; Region: FtsA; smart00842 1245469005859 Cell division protein FtsA; Region: FtsA; pfam14450 1245469005860 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 1245469005861 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1245469005862 nucleotide binding site [chemical binding]; other site 1245469005863 SulA interaction site; other site 1245469005864 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 1245469005865 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1245469005866 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1245469005867 Outer membrane lipoprotein; Region: YfiO; pfam13525 1245469005868 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1245469005869 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1245469005870 Walker A/P-loop; other site 1245469005871 ATP binding site [chemical binding]; other site 1245469005872 Q-loop/lid; other site 1245469005873 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1245469005874 ABC transporter signature motif; other site 1245469005875 Walker B; other site 1245469005876 D-loop; other site 1245469005877 H-loop/switch region; other site 1245469005878 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1245469005879 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1245469005880 nucleotide binding pocket [chemical binding]; other site 1245469005881 K-X-D-G motif; other site 1245469005882 catalytic site [active] 1245469005883 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1245469005884 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1245469005885 Dimer interface [polypeptide binding]; other site 1245469005886 BRCT sequence motif; other site 1245469005887 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1245469005888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469005889 putative substrate translocation pore; other site 1245469005890 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1245469005891 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1245469005892 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 1245469005893 active site 1245469005894 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1245469005895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469005896 S-adenosylmethionine binding site [chemical binding]; other site 1245469005897 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1245469005898 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1245469005899 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469005900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469005901 S-adenosylmethionine binding site [chemical binding]; other site 1245469005902 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 1245469005903 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469005904 ligand binding site [chemical binding]; other site 1245469005905 dimerization interface [polypeptide binding]; other site 1245469005906 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469005907 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469005908 Walker A/P-loop; other site 1245469005909 ATP binding site [chemical binding]; other site 1245469005910 Q-loop/lid; other site 1245469005911 ABC transporter signature motif; other site 1245469005912 Walker B; other site 1245469005913 D-loop; other site 1245469005914 H-loop/switch region; other site 1245469005915 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469005916 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469005917 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469005918 TM-ABC transporter signature motif; other site 1245469005919 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469005920 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1245469005921 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1245469005922 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1245469005923 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1245469005924 Walker A/P-loop; other site 1245469005925 ATP binding site [chemical binding]; other site 1245469005926 Q-loop/lid; other site 1245469005927 ABC transporter signature motif; other site 1245469005928 Walker B; other site 1245469005929 D-loop; other site 1245469005930 H-loop/switch region; other site 1245469005931 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1245469005932 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1245469005933 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1245469005934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469005935 NAD(P) binding site [chemical binding]; other site 1245469005936 active site 1245469005937 Protein of unknown function (DUF962); Region: DUF962; cl01879 1245469005938 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469005939 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469005940 ligand binding site [chemical binding]; other site 1245469005941 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1245469005942 Part of AAA domain; Region: AAA_19; pfam13245 1245469005943 Family description; Region: UvrD_C_2; pfam13538 1245469005944 TPR repeat; Region: TPR_11; pfam13414 1245469005945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1245469005946 binding surface 1245469005947 TPR motif; other site 1245469005948 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 1245469005949 ligand binding site [chemical binding]; other site 1245469005950 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 1245469005951 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469005952 ligand binding site [chemical binding]; other site 1245469005953 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1245469005954 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469005955 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1245469005956 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469005957 Amidase; Region: Amidase; pfam01425 1245469005958 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1245469005959 active site 1245469005960 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1245469005961 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469005962 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 1245469005963 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1245469005964 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1245469005965 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1245469005966 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1245469005967 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469005968 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469005969 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469005970 putative effector binding pocket; other site 1245469005971 dimerization interface [polypeptide binding]; other site 1245469005972 Predicted membrane protein [Function unknown]; Region: COG2259 1245469005973 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1245469005974 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1245469005975 putative active site [active] 1245469005976 metal binding site [ion binding]; metal-binding site 1245469005977 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1245469005978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469005979 putative substrate translocation pore; other site 1245469005980 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469005981 Cytochrome P450; Region: p450; cl12078 1245469005982 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1245469005983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469005984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469005985 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1245469005986 putative dimerization interface [polypeptide binding]; other site 1245469005987 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1245469005988 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1245469005989 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1245469005990 shikimate binding site; other site 1245469005991 NAD(P) binding site [chemical binding]; other site 1245469005992 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469005993 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1245469005994 ligand binding site [chemical binding]; other site 1245469005995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469005996 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469005997 TM-ABC transporter signature motif; other site 1245469005998 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469005999 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469006000 TM-ABC transporter signature motif; other site 1245469006001 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469006002 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469006003 Walker A/P-loop; other site 1245469006004 ATP binding site [chemical binding]; other site 1245469006005 Q-loop/lid; other site 1245469006006 ABC transporter signature motif; other site 1245469006007 Walker B; other site 1245469006008 D-loop; other site 1245469006009 H-loop/switch region; other site 1245469006010 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469006011 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469006012 Walker A/P-loop; other site 1245469006013 ATP binding site [chemical binding]; other site 1245469006014 Q-loop/lid; other site 1245469006015 ABC transporter signature motif; other site 1245469006016 Walker B; other site 1245469006017 D-loop; other site 1245469006018 H-loop/switch region; other site 1245469006019 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1245469006020 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1245469006021 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1245469006022 dimer interface [polypeptide binding]; other site 1245469006023 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1245469006024 active site 1245469006025 Fe binding site [ion binding]; other site 1245469006026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469006027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469006028 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469006029 putative effector binding pocket; other site 1245469006030 dimerization interface [polypeptide binding]; other site 1245469006031 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1245469006032 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1245469006033 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1245469006034 ferrous iron transporter FeoB; Region: feoB; TIGR00437 1245469006035 G1 box; other site 1245469006036 GTP/Mg2+ binding site [chemical binding]; other site 1245469006037 Switch I region; other site 1245469006038 G2 box; other site 1245469006039 G3 box; other site 1245469006040 Switch II region; other site 1245469006041 G4 box; other site 1245469006042 G5 box; other site 1245469006043 Nucleoside recognition; Region: Gate; pfam07670 1245469006044 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1245469006045 Nucleoside recognition; Region: Gate; pfam07670 1245469006046 FeoA domain; Region: FeoA; cl00838 1245469006047 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 1245469006048 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1245469006049 Class II fumarases; Region: Fumarase_classII; cd01362 1245469006050 active site 1245469006051 tetramer interface [polypeptide binding]; other site 1245469006052 Stringent starvation protein B; Region: SspB; pfam04386 1245469006053 Chromate transporter; Region: Chromate_transp; pfam02417 1245469006054 Chromate transporter; Region: Chromate_transp; pfam02417 1245469006055 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1245469006056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1245469006057 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1245469006058 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1245469006059 dimerization interface [polypeptide binding]; other site 1245469006060 active site 1245469006061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469006062 Coenzyme A binding pocket [chemical binding]; other site 1245469006063 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1245469006064 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1245469006065 folate binding site [chemical binding]; other site 1245469006066 NADP+ binding site [chemical binding]; other site 1245469006067 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1245469006068 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1245469006069 HflK protein; Region: hflK; TIGR01933 1245469006070 HflC protein; Region: hflC; TIGR01932 1245469006071 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1245469006072 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1245469006073 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1245469006074 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469006075 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469006076 protein binding site [polypeptide binding]; other site 1245469006077 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469006078 protein binding site [polypeptide binding]; other site 1245469006079 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1245469006080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469006081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469006082 dimerization interface [polypeptide binding]; other site 1245469006083 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1245469006084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469006085 putative substrate translocation pore; other site 1245469006086 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1245469006087 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1245469006088 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469006089 motif II; other site 1245469006090 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1245469006091 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1245469006092 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 1245469006093 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469006094 PYR/PP interface [polypeptide binding]; other site 1245469006095 dimer interface [polypeptide binding]; other site 1245469006096 TPP binding site [chemical binding]; other site 1245469006097 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469006098 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1245469006099 TPP-binding site [chemical binding]; other site 1245469006100 dimer interface [polypeptide binding]; other site 1245469006101 hypothetical protein; Provisional; Region: PRK06815 1245469006102 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1245469006103 tetramer interface [polypeptide binding]; other site 1245469006104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469006105 catalytic residue [active] 1245469006106 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1245469006107 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1245469006108 putative valine binding site [chemical binding]; other site 1245469006109 dimer interface [polypeptide binding]; other site 1245469006110 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1245469006111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469006112 S-adenosylmethionine binding site [chemical binding]; other site 1245469006113 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1245469006114 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1245469006115 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1245469006116 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1245469006117 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1245469006118 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469006119 N-terminal plug; other site 1245469006120 ligand-binding site [chemical binding]; other site 1245469006121 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 1245469006122 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1245469006123 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1245469006124 catalytic core [active] 1245469006125 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469006126 short chain dehydrogenase; Provisional; Region: PRK06914 1245469006127 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1245469006128 NADP binding site [chemical binding]; other site 1245469006129 active site 1245469006130 steroid binding site; other site 1245469006131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469006132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469006133 active site 1245469006134 phosphorylation site [posttranslational modification] 1245469006135 intermolecular recognition site; other site 1245469006136 dimerization interface [polypeptide binding]; other site 1245469006137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469006138 DNA binding residues [nucleotide binding] 1245469006139 dimerization interface [polypeptide binding]; other site 1245469006140 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1245469006141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469006142 dimerization interface [polypeptide binding]; other site 1245469006143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1245469006144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469006145 ATP binding site [chemical binding]; other site 1245469006146 Mg2+ binding site [ion binding]; other site 1245469006147 G-X-G motif; other site 1245469006148 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1245469006149 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1245469006150 Sulfatase; Region: Sulfatase; cl17466 1245469006151 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469006152 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469006153 putative ligand binding site [chemical binding]; other site 1245469006154 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1245469006155 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469006156 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469006157 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469006158 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1245469006159 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 1245469006160 active site 1245469006161 catalytic residue [active] 1245469006162 H+ Antiporter protein; Region: 2A0121; TIGR00900 1245469006163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469006164 putative substrate translocation pore; other site 1245469006165 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469006166 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1245469006167 catalytic triad [active] 1245469006168 conserved cis-peptide bond; other site 1245469006169 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469006170 MarR family; Region: MarR; pfam01047 1245469006171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006172 ABC-ATPase subunit interface; other site 1245469006173 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1245469006174 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1245469006175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469006176 Walker B; other site 1245469006177 D-loop; other site 1245469006178 H-loop/switch region; other site 1245469006179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469006180 Walker A/P-loop; other site 1245469006181 ATP binding site [chemical binding]; other site 1245469006182 Q-loop/lid; other site 1245469006183 ABC transporter signature motif; other site 1245469006184 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469006185 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469006186 Walker A/P-loop; other site 1245469006187 ATP binding site [chemical binding]; other site 1245469006188 Q-loop/lid; other site 1245469006189 ABC transporter signature motif; other site 1245469006190 Walker B; other site 1245469006191 D-loop; other site 1245469006192 H-loop/switch region; other site 1245469006193 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469006194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006195 dimer interface [polypeptide binding]; other site 1245469006196 conserved gate region; other site 1245469006197 putative PBP binding loops; other site 1245469006198 ABC-ATPase subunit interface; other site 1245469006199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469006200 substrate binding pocket [chemical binding]; other site 1245469006201 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469006202 membrane-bound complex binding site; other site 1245469006203 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1245469006204 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1245469006205 CHASE2 domain; Region: CHASE2; pfam05226 1245469006206 PAS domain S-box; Region: sensory_box; TIGR00229 1245469006207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469006208 putative active site [active] 1245469006209 heme pocket [chemical binding]; other site 1245469006210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469006211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469006212 metal binding site [ion binding]; metal-binding site 1245469006213 active site 1245469006214 I-site; other site 1245469006215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469006216 FecR protein; Region: FecR; pfam04773 1245469006217 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1245469006218 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1245469006219 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1245469006220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469006221 putative substrate translocation pore; other site 1245469006222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1245469006223 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1245469006224 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469006225 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469006226 ligand binding site [chemical binding]; other site 1245469006227 flexible hinge region; other site 1245469006228 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1245469006229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469006230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469006231 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1245469006232 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1245469006233 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1245469006234 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469006235 N-terminal plug; other site 1245469006236 ligand-binding site [chemical binding]; other site 1245469006237 PAS fold; Region: PAS_4; pfam08448 1245469006238 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469006239 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469006240 2-isopropylmalate synthase; Validated; Region: PRK00915 1245469006241 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1245469006242 active site 1245469006243 catalytic residues [active] 1245469006244 metal binding site [ion binding]; metal-binding site 1245469006245 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1245469006246 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469006247 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1245469006248 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1245469006249 DctM-like transporters; Region: DctM; pfam06808 1245469006250 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 1245469006251 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1245469006252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1245469006253 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1245469006254 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469006255 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1245469006256 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469006257 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1245469006258 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469006259 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469006260 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469006261 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469006262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469006263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469006264 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 1245469006265 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1245469006266 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1245469006267 substrate binding site [chemical binding]; other site 1245469006268 trimer interface [polypeptide binding]; other site 1245469006269 Mn binding site [ion binding]; other site 1245469006270 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1245469006271 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1245469006272 active site 1245469006273 catalytic residues [active] 1245469006274 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1245469006275 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1245469006276 active site 1245469006277 dimerization interface [polypeptide binding]; other site 1245469006278 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1245469006279 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1245469006280 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469006281 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469006282 catalytic loop [active] 1245469006283 iron binding site [ion binding]; other site 1245469006284 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469006285 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469006286 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469006287 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469006288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1245469006289 active site 1245469006290 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1245469006291 putative FMN binding site [chemical binding]; other site 1245469006292 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469006293 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1245469006294 NAD(P) binding site [chemical binding]; other site 1245469006295 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469006296 NAD(P) binding site [chemical binding]; other site 1245469006297 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469006298 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469006299 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469006300 putative ligand binding site [chemical binding]; other site 1245469006301 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469006302 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469006303 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469006304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469006305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469006306 Cytochrome P450; Region: p450; cl12078 1245469006307 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1245469006308 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469006309 dimer interface [polypeptide binding]; other site 1245469006310 active site 1245469006311 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1245469006312 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469006313 substrate binding site [chemical binding]; other site 1245469006314 oxyanion hole (OAH) forming residues; other site 1245469006315 trimer interface [polypeptide binding]; other site 1245469006316 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469006317 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469006318 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469006319 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469006320 putative ligand binding site [chemical binding]; other site 1245469006321 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 1245469006322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469006323 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469006324 acyl-activating enzyme (AAE) consensus motif; other site 1245469006325 putative AMP binding site [chemical binding]; other site 1245469006326 putative active site [active] 1245469006327 putative CoA binding site [chemical binding]; other site 1245469006328 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469006329 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469006330 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1245469006331 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1245469006332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469006333 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469006334 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469006335 active site 1245469006336 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1245469006337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469006338 DNA-binding site [nucleotide binding]; DNA binding site 1245469006339 FCD domain; Region: FCD; pfam07729 1245469006340 Coenzyme A transferase; Region: CoA_trans; cl17247 1245469006341 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1245469006342 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469006343 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469006344 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469006345 Cytochrome P450; Region: p450; cl12078 1245469006346 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1245469006347 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 1245469006348 catalytic Zn binding site [ion binding]; other site 1245469006349 NAD binding site [chemical binding]; other site 1245469006350 structural Zn binding site [ion binding]; other site 1245469006351 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469006352 Cytochrome P450; Region: p450; cl12078 1245469006353 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1245469006354 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1245469006355 active site 1245469006356 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1245469006357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469006358 active site 1245469006359 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1245469006360 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1245469006361 FMN binding site [chemical binding]; other site 1245469006362 substrate binding site [chemical binding]; other site 1245469006363 putative catalytic residue [active] 1245469006364 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1245469006365 DUF35 OB-fold domain; Region: DUF35; pfam01796 1245469006366 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1245469006367 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1245469006368 active site 1245469006369 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1245469006370 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1245469006371 dimer interaction site [polypeptide binding]; other site 1245469006372 substrate-binding tunnel; other site 1245469006373 active site 1245469006374 catalytic site [active] 1245469006375 substrate binding site [chemical binding]; other site 1245469006376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469006377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469006378 NAD(P) binding site [chemical binding]; other site 1245469006379 active site 1245469006380 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469006381 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469006382 putative ligand binding site [chemical binding]; other site 1245469006383 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469006384 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469006385 active site 1245469006386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469006387 MarR family; Region: MarR; pfam01047 1245469006388 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 1245469006389 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1245469006390 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1245469006391 hydrophobic ligand binding site; other site 1245469006392 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1245469006393 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1245469006394 FMN-binding pocket [chemical binding]; other site 1245469006395 flavin binding motif; other site 1245469006396 phosphate binding motif [ion binding]; other site 1245469006397 beta-alpha-beta structure motif; other site 1245469006398 NAD binding pocket [chemical binding]; other site 1245469006399 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469006400 catalytic loop [active] 1245469006401 iron binding site [ion binding]; other site 1245469006402 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1245469006403 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1245469006404 Metal-binding active site; metal-binding site 1245469006405 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1245469006406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1245469006407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469006408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1245469006409 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1245469006410 peptide synthase; Provisional; Region: PRK12467 1245469006411 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469006412 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469006413 acyl-activating enzyme (AAE) consensus motif; other site 1245469006414 AMP binding site [chemical binding]; other site 1245469006415 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469006416 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469006417 acyl-activating enzyme (AAE) consensus motif; other site 1245469006418 AMP binding site [chemical binding]; other site 1245469006419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469006420 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469006421 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469006422 acyl-activating enzyme (AAE) consensus motif; other site 1245469006423 AMP binding site [chemical binding]; other site 1245469006424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469006425 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 1245469006426 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469006427 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1245469006428 acyl-activating enzyme (AAE) consensus motif; other site 1245469006429 AMP binding site [chemical binding]; other site 1245469006430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469006431 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1245469006432 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1245469006433 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1245469006434 active site 1245469006435 dimer interface [polypeptide binding]; other site 1245469006436 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1245469006437 Ligand Binding Site [chemical binding]; other site 1245469006438 Molecular Tunnel; other site 1245469006439 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1245469006440 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469006441 FeS/SAM binding site; other site 1245469006442 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1245469006443 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469006444 Walker A/P-loop; other site 1245469006445 ATP binding site [chemical binding]; other site 1245469006446 Q-loop/lid; other site 1245469006447 ABC transporter signature motif; other site 1245469006448 Walker B; other site 1245469006449 D-loop; other site 1245469006450 H-loop/switch region; other site 1245469006451 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1245469006452 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 1245469006453 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1245469006454 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1245469006455 catalytic residues [active] 1245469006456 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1245469006457 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1245469006458 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1245469006459 DsbD alpha interface [polypeptide binding]; other site 1245469006460 catalytic residues [active] 1245469006461 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1245469006462 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1245469006463 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469006464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469006465 ligand binding site [chemical binding]; other site 1245469006466 flexible hinge region; other site 1245469006467 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469006468 putative switch regulator; other site 1245469006469 non-specific DNA interactions [nucleotide binding]; other site 1245469006470 DNA binding site [nucleotide binding] 1245469006471 sequence specific DNA binding site [nucleotide binding]; other site 1245469006472 putative cAMP binding site [chemical binding]; other site 1245469006473 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469006474 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469006475 Walker A/P-loop; other site 1245469006476 ATP binding site [chemical binding]; other site 1245469006477 Q-loop/lid; other site 1245469006478 ABC transporter signature motif; other site 1245469006479 Walker B; other site 1245469006480 D-loop; other site 1245469006481 H-loop/switch region; other site 1245469006482 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469006483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006484 dimer interface [polypeptide binding]; other site 1245469006485 conserved gate region; other site 1245469006486 putative PBP binding loops; other site 1245469006487 ABC-ATPase subunit interface; other site 1245469006488 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469006489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469006490 substrate binding pocket [chemical binding]; other site 1245469006491 membrane-bound complex binding site; other site 1245469006492 NosL; Region: NosL; cl01769 1245469006493 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469006494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469006495 ligand binding site [chemical binding]; other site 1245469006496 flexible hinge region; other site 1245469006497 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469006498 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1245469006499 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1245469006500 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1245469006501 FAD binding pocket [chemical binding]; other site 1245469006502 FAD binding motif [chemical binding]; other site 1245469006503 phosphate binding motif [ion binding]; other site 1245469006504 beta-alpha-beta structure motif; other site 1245469006505 NAD binding pocket [chemical binding]; other site 1245469006506 putative oxidoreductase; Provisional; Region: PRK08275 1245469006507 L-aspartate oxidase; Provisional; Region: PRK06175 1245469006508 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1245469006509 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1245469006510 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1245469006511 HEAT repeats; Region: HEAT_2; pfam13646 1245469006512 HEAT repeats; Region: HEAT_2; pfam13646 1245469006513 Sister chromatid cohesion C-terminus; Region: Nipped-B_C; pfam12830 1245469006514 HEAT repeats; Region: HEAT_2; pfam13646 1245469006515 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1245469006516 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469006517 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1245469006518 putative dimerization interface [polypeptide binding]; other site 1245469006519 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469006520 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1245469006521 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469006522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469006523 Walker A/P-loop; other site 1245469006524 ATP binding site [chemical binding]; other site 1245469006525 Q-loop/lid; other site 1245469006526 ABC transporter signature motif; other site 1245469006527 Walker B; other site 1245469006528 D-loop; other site 1245469006529 H-loop/switch region; other site 1245469006530 TOBE domain; Region: TOBE_2; pfam08402 1245469006531 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469006532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006533 dimer interface [polypeptide binding]; other site 1245469006534 conserved gate region; other site 1245469006535 putative PBP binding loops; other site 1245469006536 ABC-ATPase subunit interface; other site 1245469006537 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469006538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006539 dimer interface [polypeptide binding]; other site 1245469006540 conserved gate region; other site 1245469006541 putative PBP binding loops; other site 1245469006542 ABC-ATPase subunit interface; other site 1245469006543 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469006544 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1245469006545 catalytic loop [active] 1245469006546 iron binding site [ion binding]; other site 1245469006547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1245469006548 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1245469006549 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469006550 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469006551 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1245469006552 homotrimer interaction site [polypeptide binding]; other site 1245469006553 putative active site [active] 1245469006554 hypothetical protein; Provisional; Region: PRK08201 1245469006555 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1245469006556 metal binding site [ion binding]; metal-binding site 1245469006557 putative dimer interface [polypeptide binding]; other site 1245469006558 Domain of unknown function (DUF892); Region: DUF892; cl17410 1245469006559 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1245469006560 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1245469006561 hypothetical protein; Provisional; Region: PRK14812 1245469006562 substrate binding site [chemical binding]; other site 1245469006563 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1245469006564 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1245469006565 substrate binding site [chemical binding]; other site 1245469006566 ligand binding site [chemical binding]; other site 1245469006567 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1245469006568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469006569 DNA-binding site [nucleotide binding]; DNA binding site 1245469006570 UTRA domain; Region: UTRA; pfam07702 1245469006571 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1245469006572 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 1245469006573 putative ligand binding site [chemical binding]; other site 1245469006574 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469006575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469006576 TM-ABC transporter signature motif; other site 1245469006577 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469006578 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469006579 TM-ABC transporter signature motif; other site 1245469006580 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469006581 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469006582 Walker A/P-loop; other site 1245469006583 ATP binding site [chemical binding]; other site 1245469006584 Q-loop/lid; other site 1245469006585 ABC transporter signature motif; other site 1245469006586 Walker B; other site 1245469006587 D-loop; other site 1245469006588 H-loop/switch region; other site 1245469006589 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469006590 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469006591 Walker A/P-loop; other site 1245469006592 ATP binding site [chemical binding]; other site 1245469006593 Q-loop/lid; other site 1245469006594 ABC transporter signature motif; other site 1245469006595 Walker B; other site 1245469006596 D-loop; other site 1245469006597 H-loop/switch region; other site 1245469006598 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1245469006599 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1245469006600 tetramer interface [polypeptide binding]; other site 1245469006601 active site 1245469006602 Mg2+/Mn2+ binding site [ion binding]; other site 1245469006603 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1245469006604 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1245469006605 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1245469006606 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1245469006607 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1245469006608 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469006609 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1245469006610 catalytic triad [active] 1245469006611 conserved cis-peptide bond; other site 1245469006612 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 1245469006613 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469006614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006615 dimer interface [polypeptide binding]; other site 1245469006616 conserved gate region; other site 1245469006617 putative PBP binding loops; other site 1245469006618 ABC-ATPase subunit interface; other site 1245469006619 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469006620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006621 dimer interface [polypeptide binding]; other site 1245469006622 conserved gate region; other site 1245469006623 putative PBP binding loops; other site 1245469006624 ABC-ATPase subunit interface; other site 1245469006625 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469006626 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469006627 Walker A/P-loop; other site 1245469006628 ATP binding site [chemical binding]; other site 1245469006629 Q-loop/lid; other site 1245469006630 ABC transporter signature motif; other site 1245469006631 Walker B; other site 1245469006632 D-loop; other site 1245469006633 H-loop/switch region; other site 1245469006634 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469006635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469006636 DNA-binding site [nucleotide binding]; DNA binding site 1245469006637 FCD domain; Region: FCD; pfam07729 1245469006638 NMT1-like family; Region: NMT1_2; pfam13379 1245469006639 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469006640 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469006641 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469006642 Putative cyclase; Region: Cyclase; pfam04199 1245469006643 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469006644 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469006645 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1245469006646 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1245469006647 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1245469006648 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1245469006649 Transposase; Region: HTH_Tnp_1; cl17663 1245469006650 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469006651 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469006652 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469006653 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469006654 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469006655 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469006656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469006657 catalytic loop [active] 1245469006658 iron binding site [ion binding]; other site 1245469006659 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469006660 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 1245469006661 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1245469006662 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1245469006663 substrate binding site [chemical binding]; other site 1245469006664 catalytic Zn binding site [ion binding]; other site 1245469006665 NAD binding site [chemical binding]; other site 1245469006666 structural Zn binding site [ion binding]; other site 1245469006667 dimer interface [polypeptide binding]; other site 1245469006668 c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874 1245469006669 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469006670 Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278 1245469006671 Trp docking motif [polypeptide binding]; other site 1245469006672 dimer interface [polypeptide binding]; other site 1245469006673 active site 1245469006674 small subunit binding site [polypeptide binding]; other site 1245469006675 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1245469006676 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1245469006677 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469006678 substrate binding pocket [chemical binding]; other site 1245469006679 membrane-bound complex binding site; other site 1245469006680 hinge residues; other site 1245469006681 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469006682 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469006683 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1245469006684 dimer interface [polypeptide binding]; other site 1245469006685 Trp docking motif [polypeptide binding]; other site 1245469006686 active site 1245469006687 EthD domain; Region: EthD; cl17553 1245469006688 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469006689 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469006690 Walker A/P-loop; other site 1245469006691 ATP binding site [chemical binding]; other site 1245469006692 Q-loop/lid; other site 1245469006693 ABC transporter signature motif; other site 1245469006694 Walker B; other site 1245469006695 D-loop; other site 1245469006696 H-loop/switch region; other site 1245469006697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006698 dimer interface [polypeptide binding]; other site 1245469006699 conserved gate region; other site 1245469006700 putative PBP binding loops; other site 1245469006701 ABC-ATPase subunit interface; other site 1245469006702 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469006703 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469006704 substrate binding pocket [chemical binding]; other site 1245469006705 membrane-bound complex binding site; other site 1245469006706 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1245469006707 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1245469006708 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469006709 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1245469006710 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469006711 substrate binding pocket [chemical binding]; other site 1245469006712 membrane-bound complex binding site; other site 1245469006713 hinge residues; other site 1245469006714 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1245469006715 active site residue [active] 1245469006716 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1245469006717 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1245469006718 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1245469006719 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1245469006720 Walker A/P-loop; other site 1245469006721 ATP binding site [chemical binding]; other site 1245469006722 Q-loop/lid; other site 1245469006723 ABC transporter signature motif; other site 1245469006724 Walker B; other site 1245469006725 D-loop; other site 1245469006726 H-loop/switch region; other site 1245469006727 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1245469006728 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469006729 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469006730 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469006731 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469006732 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1245469006733 ligand binding site [chemical binding]; other site 1245469006734 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1245469006735 S-formylglutathione hydrolase; Region: PLN02442 1245469006736 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1245469006737 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469006738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469006739 active site 1245469006740 phosphorylation site [posttranslational modification] 1245469006741 intermolecular recognition site; other site 1245469006742 dimerization interface [polypeptide binding]; other site 1245469006743 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469006744 DNA binding residues [nucleotide binding] 1245469006745 dimerization interface [polypeptide binding]; other site 1245469006746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469006747 dimerization interface [polypeptide binding]; other site 1245469006748 Histidine kinase; Region: HisKA_3; pfam07730 1245469006749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469006750 ATP binding site [chemical binding]; other site 1245469006751 Mg2+ binding site [ion binding]; other site 1245469006752 G-X-G motif; other site 1245469006753 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1245469006754 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1245469006755 short chain dehydrogenase; Provisional; Region: PRK06701 1245469006756 NAD binding site [chemical binding]; other site 1245469006757 metal binding site [ion binding]; metal-binding site 1245469006758 active site 1245469006759 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1245469006760 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1245469006761 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469006762 classical (c) SDRs; Region: SDR_c; cd05233 1245469006763 NAD(P) binding site [chemical binding]; other site 1245469006764 active site 1245469006765 Nif-specific regulatory protein; Region: nifA; TIGR01817 1245469006766 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1245469006767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469006768 Walker A motif; other site 1245469006769 ATP binding site [chemical binding]; other site 1245469006770 Walker B motif; other site 1245469006771 arginine finger; other site 1245469006772 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469006773 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1245469006774 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1245469006775 putative ABC transporter; Region: ycf24; CHL00085 1245469006776 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1245469006777 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1245469006778 Walker A/P-loop; other site 1245469006779 ATP binding site [chemical binding]; other site 1245469006780 Q-loop/lid; other site 1245469006781 ABC transporter signature motif; other site 1245469006782 Walker B; other site 1245469006783 D-loop; other site 1245469006784 H-loop/switch region; other site 1245469006785 FeS assembly protein SufD; Region: sufD; TIGR01981 1245469006786 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1245469006787 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1245469006788 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1245469006789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469006790 catalytic residue [active] 1245469006791 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1245469006792 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469006793 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469006794 active site 1245469006795 phosphorylation site [posttranslational modification] 1245469006796 intermolecular recognition site; other site 1245469006797 dimerization interface [polypeptide binding]; other site 1245469006798 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1245469006799 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1245469006800 Nucleotide-binding sites [chemical binding]; other site 1245469006801 Walker A motif; other site 1245469006802 Switch I region of nucleotide binding site; other site 1245469006803 Fe4S4 binding sites [ion binding]; other site 1245469006804 Switch II region of nucleotide binding site; other site 1245469006805 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 1245469006806 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 1245469006807 MoFe protein alpha/beta subunit interactions; other site 1245469006808 Alpha subunit P cluster binding residues; other site 1245469006809 FeMoco binding residues [chemical binding]; other site 1245469006810 MoFe protein alpha subunit/Fe protein contacts; other site 1245469006811 MoFe protein dimer/ dimer interactions; other site 1245469006812 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 1245469006813 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 1245469006814 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 1245469006815 MoFe protein beta/alpha subunit interactions; other site 1245469006816 Beta subunit P cluster binding residues; other site 1245469006817 MoFe protein beta subunit/Fe protein contacts; other site 1245469006818 MoFe protein dimer/ dimer interactions; other site 1245469006819 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1245469006820 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 1245469006821 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1245469006822 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 1245469006823 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1245469006824 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 1245469006825 probable nitrogen fixation protein; Region: TIGR02935 1245469006826 Rop-like; Region: Rop-like; pfam05082 1245469006827 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 1245469006828 4Fe-4S binding domain; Region: Fer4; cl02805 1245469006829 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 1245469006830 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1245469006831 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1245469006832 active site residue [active] 1245469006833 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1245469006834 active site residue [active] 1245469006835 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1245469006836 iron-sulfur cluster [ion binding]; other site 1245469006837 [2Fe-2S] cluster binding site [ion binding]; other site 1245469006838 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1245469006839 NifU-like domain; Region: NifU; cl00484 1245469006840 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1245469006841 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1245469006842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469006843 catalytic residue [active] 1245469006844 NifT/FixU protein; Region: NifT; pfam06988 1245469006845 SIR2-like domain; Region: SIR2_2; pfam13289 1245469006846 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1245469006847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469006848 FeS/SAM binding site; other site 1245469006849 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 1245469006850 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1245469006851 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1245469006852 LRV protein FeS4 cluster; Region: LRV_FeS; pfam05484 1245469006853 NifZ domain; Region: NifZ; pfam04319 1245469006854 NifZ domain; Region: NifZ; pfam04319 1245469006855 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1245469006856 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1245469006857 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1245469006858 inhibitor-cofactor binding pocket; inhibition site 1245469006859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469006860 catalytic residue [active] 1245469006861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469006862 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469006863 catalytic loop [active] 1245469006864 iron binding site [ion binding]; other site 1245469006865 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1245469006866 apolar tunnel; other site 1245469006867 heme binding site [chemical binding]; other site 1245469006868 dimerization interface [polypeptide binding]; other site 1245469006869 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469006870 Domain of unknown function DUF59; Region: DUF59; cl00941 1245469006871 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1245469006872 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1245469006873 putative GSH binding site [chemical binding]; other site 1245469006874 catalytic residues [active] 1245469006875 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1245469006876 dimer interface [polypeptide binding]; other site 1245469006877 [2Fe-2S] cluster binding site [ion binding]; other site 1245469006878 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 1245469006879 ArsC family; Region: ArsC; pfam03960 1245469006880 putative catalytic residues [active] 1245469006881 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469006883 active site 1245469006884 phosphorylation site [posttranslational modification] 1245469006885 intermolecular recognition site; other site 1245469006886 dimerization interface [polypeptide binding]; other site 1245469006887 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 1245469006888 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1245469006889 Nucleotide-binding sites [chemical binding]; other site 1245469006890 Walker A motif; other site 1245469006891 Switch I region of nucleotide binding site; other site 1245469006892 Fe4S4 binding sites [ion binding]; other site 1245469006893 Switch II region of nucleotide binding site; other site 1245469006894 NifQ; Region: NifQ; pfam04891 1245469006895 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 1245469006896 metal binding site 2 [ion binding]; metal-binding site 1245469006897 putative DNA binding helix; other site 1245469006898 metal binding site 1 [ion binding]; metal-binding site 1245469006899 structural Zn2+ binding site [ion binding]; other site 1245469006900 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 1245469006901 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 1245469006902 active site 1245469006903 catalytic residues [active] 1245469006904 metal binding site [ion binding]; metal-binding site 1245469006905 serine O-acetyltransferase; Region: cysE; TIGR01172 1245469006906 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1245469006907 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1245469006908 trimer interface [polypeptide binding]; other site 1245469006909 active site 1245469006910 substrate binding site [chemical binding]; other site 1245469006911 CoA binding site [chemical binding]; other site 1245469006912 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK00810 1245469006913 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1245469006914 Ligand binding site [chemical binding]; other site 1245469006915 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1245469006916 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1245469006917 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1245469006918 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1245469006919 oxidoreductase; Provisional; Region: PRK10015 1245469006920 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1245469006921 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1245469006922 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1245469006923 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1245469006924 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 1245469006925 active site 1245469006926 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469006927 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469006928 putative ligand binding site [chemical binding]; other site 1245469006929 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469006930 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1245469006931 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1245469006932 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1245469006933 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1245469006934 dimer interface [polypeptide binding]; other site 1245469006935 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1245469006936 catalytic triad [active] 1245469006937 peroxidatic and resolving cysteines [active] 1245469006938 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469006939 classical (c) SDRs; Region: SDR_c; cd05233 1245469006940 NAD(P) binding site [chemical binding]; other site 1245469006941 active site 1245469006942 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 1245469006943 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1245469006944 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469006945 active site 1245469006946 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1245469006947 trimer interface [polypeptide binding]; other site 1245469006948 active site 1245469006949 substrate binding site [chemical binding]; other site 1245469006950 CoA binding site [chemical binding]; other site 1245469006951 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1245469006952 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1245469006953 Walker A/P-loop; other site 1245469006954 ATP binding site [chemical binding]; other site 1245469006955 Q-loop/lid; other site 1245469006956 ABC transporter signature motif; other site 1245469006957 Walker B; other site 1245469006958 D-loop; other site 1245469006959 H-loop/switch region; other site 1245469006960 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1245469006961 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469006962 substrate binding pocket [chemical binding]; other site 1245469006963 membrane-bound complex binding site; other site 1245469006964 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1245469006965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006966 dimer interface [polypeptide binding]; other site 1245469006967 conserved gate region; other site 1245469006968 putative PBP binding loops; other site 1245469006969 ABC-ATPase subunit interface; other site 1245469006970 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1245469006971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006972 dimer interface [polypeptide binding]; other site 1245469006973 conserved gate region; other site 1245469006974 ABC-ATPase subunit interface; other site 1245469006975 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1245469006976 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469006977 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1245469006978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006979 dimer interface [polypeptide binding]; other site 1245469006980 conserved gate region; other site 1245469006981 ABC-ATPase subunit interface; other site 1245469006982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469006983 putative PBP binding loops; other site 1245469006984 dimer interface [polypeptide binding]; other site 1245469006985 ABC-ATPase subunit interface; other site 1245469006986 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469006987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469006988 Walker A/P-loop; other site 1245469006989 ATP binding site [chemical binding]; other site 1245469006990 Q-loop/lid; other site 1245469006991 ABC transporter signature motif; other site 1245469006992 Walker B; other site 1245469006993 D-loop; other site 1245469006994 H-loop/switch region; other site 1245469006995 TOBE domain; Region: TOBE_2; pfam08402 1245469006996 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1245469006997 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469006998 active site 1245469006999 metal binding site [ion binding]; metal-binding site 1245469007000 hexamer interface [polypeptide binding]; other site 1245469007001 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1245469007002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469007003 DNA-binding site [nucleotide binding]; DNA binding site 1245469007004 UTRA domain; Region: UTRA; pfam07702 1245469007005 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1245469007006 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 1245469007007 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1245469007008 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 1245469007009 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1245469007010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469007011 Walker A/P-loop; other site 1245469007012 ATP binding site [chemical binding]; other site 1245469007013 Q-loop/lid; other site 1245469007014 ABC transporter signature motif; other site 1245469007015 Walker B; other site 1245469007016 D-loop; other site 1245469007017 H-loop/switch region; other site 1245469007018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469007019 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1245469007020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469007021 Walker A/P-loop; other site 1245469007022 ATP binding site [chemical binding]; other site 1245469007023 Q-loop/lid; other site 1245469007024 ABC transporter signature motif; other site 1245469007025 Walker B; other site 1245469007026 D-loop; other site 1245469007027 H-loop/switch region; other site 1245469007028 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1245469007029 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1245469007030 active site 1245469007031 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1245469007032 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 1245469007033 Predicted integral membrane protein [Function unknown]; Region: COG0392 1245469007034 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1245469007035 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1245469007036 NADP binding site [chemical binding]; other site 1245469007037 dimer interface [polypeptide binding]; other site 1245469007038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1245469007039 non-specific DNA binding site [nucleotide binding]; other site 1245469007040 salt bridge; other site 1245469007041 Predicted transcriptional regulator [Transcription]; Region: COG2932 1245469007042 sequence-specific DNA binding site [nucleotide binding]; other site 1245469007043 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1245469007044 Catalytic site [active] 1245469007045 GcrA cell cycle regulator; Region: GcrA; cl11564 1245469007046 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1245469007047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469007048 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469007049 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469007050 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469007051 Surface antigen; Region: Bac_surface_Ag; pfam01103 1245469007052 Cupin domain; Region: Cupin_2; cl17218 1245469007053 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 1245469007054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469007055 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469007056 putative substrate translocation pore; other site 1245469007057 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1245469007058 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1245469007059 conserved cys residue [active] 1245469007060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469007061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469007062 Phasin protein; Region: Phasin_2; cl11491 1245469007063 Cytochrome c; Region: Cytochrom_C; cl11414 1245469007064 OpgC protein; Region: OpgC_C; pfam10129 1245469007065 Arginase family; Region: Arginase; cd09989 1245469007066 agmatinase; Region: agmatinase; TIGR01230 1245469007067 active site 1245469007068 Mn binding site [ion binding]; other site 1245469007069 oligomer interface [polypeptide binding]; other site 1245469007070 malate dehydrogenase; Provisional; Region: PRK13529 1245469007071 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1245469007072 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1245469007073 NAD(P) binding site [chemical binding]; other site 1245469007074 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1245469007075 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1245469007076 GAF domain; Region: GAF_3; pfam13492 1245469007077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469007078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469007079 dimer interface [polypeptide binding]; other site 1245469007080 phosphorylation site [posttranslational modification] 1245469007081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469007082 ATP binding site [chemical binding]; other site 1245469007083 Mg2+ binding site [ion binding]; other site 1245469007084 G-X-G motif; other site 1245469007085 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469007086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469007087 active site 1245469007088 phosphorylation site [posttranslational modification] 1245469007089 intermolecular recognition site; other site 1245469007090 dimerization interface [polypeptide binding]; other site 1245469007091 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1245469007092 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469007093 putative active site [active] 1245469007094 heme pocket [chemical binding]; other site 1245469007095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469007096 dimer interface [polypeptide binding]; other site 1245469007097 phosphorylation site [posttranslational modification] 1245469007098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469007099 ATP binding site [chemical binding]; other site 1245469007100 Mg2+ binding site [ion binding]; other site 1245469007101 G-X-G motif; other site 1245469007102 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469007103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469007104 active site 1245469007105 phosphorylation site [posttranslational modification] 1245469007106 intermolecular recognition site; other site 1245469007107 dimerization interface [polypeptide binding]; other site 1245469007108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469007109 Coenzyme A binding pocket [chemical binding]; other site 1245469007110 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469007111 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469007112 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469007113 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 1245469007114 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469007115 BON domain; Region: BON; pfam04972 1245469007116 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 1245469007117 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1245469007118 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1245469007119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1245469007120 AAA domain; Region: AAA_33; pfam13671 1245469007121 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1245469007122 active site 1245469007123 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1245469007124 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1245469007125 putative NAD(P) binding site [chemical binding]; other site 1245469007126 putative substrate binding site [chemical binding]; other site 1245469007127 catalytic Zn binding site [ion binding]; other site 1245469007128 structural Zn binding site [ion binding]; other site 1245469007129 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1245469007130 CoA binding domain; Region: CoA_binding_2; pfam13380 1245469007131 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1245469007132 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1245469007133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1245469007134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469007135 Coenzyme A binding pocket [chemical binding]; other site 1245469007136 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1245469007137 Permease; Region: Permease; pfam02405 1245469007138 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1245469007139 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1245469007140 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1245469007141 Walker A/P-loop; other site 1245469007142 ATP binding site [chemical binding]; other site 1245469007143 Q-loop/lid; other site 1245469007144 ABC transporter signature motif; other site 1245469007145 Walker B; other site 1245469007146 D-loop; other site 1245469007147 H-loop/switch region; other site 1245469007148 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1245469007149 mce related protein; Region: MCE; pfam02470 1245469007150 Protein of unknown function (DUF330); Region: DUF330; cl01135 1245469007151 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469007152 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469007153 ligand binding site [chemical binding]; other site 1245469007154 flexible hinge region; other site 1245469007155 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469007156 putative switch regulator; other site 1245469007157 non-specific DNA interactions [nucleotide binding]; other site 1245469007158 DNA binding site [nucleotide binding] 1245469007159 sequence specific DNA binding site [nucleotide binding]; other site 1245469007160 putative cAMP binding site [chemical binding]; other site 1245469007161 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469007162 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469007163 ligand binding site [chemical binding]; other site 1245469007164 flexible hinge region; other site 1245469007165 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469007166 putative switch regulator; other site 1245469007167 non-specific DNA interactions [nucleotide binding]; other site 1245469007168 DNA binding site [nucleotide binding] 1245469007169 sequence specific DNA binding site [nucleotide binding]; other site 1245469007170 putative cAMP binding site [chemical binding]; other site 1245469007171 DctM-like transporters; Region: DctM; pfam06808 1245469007172 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469007173 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1245469007174 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469007175 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1245469007176 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469007177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469007178 DNA-binding site [nucleotide binding]; DNA binding site 1245469007179 FCD domain; Region: FCD; pfam07729 1245469007180 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1245469007181 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1245469007182 putative [4Fe-4S] binding site [ion binding]; other site 1245469007183 putative molybdopterin cofactor binding site [chemical binding]; other site 1245469007184 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1245469007185 putative molybdopterin cofactor binding site; other site 1245469007186 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 1245469007187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469007188 putative substrate translocation pore; other site 1245469007189 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1245469007190 putative acyl-acceptor binding pocket; other site 1245469007191 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1245469007192 acyl-activating enzyme (AAE) consensus motif; other site 1245469007193 putative AMP binding site [chemical binding]; other site 1245469007194 PGAP1-like protein; Region: PGAP1; pfam07819 1245469007195 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469007196 enoyl-CoA hydratase; Provisional; Region: PRK05995 1245469007197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469007198 substrate binding site [chemical binding]; other site 1245469007199 oxyanion hole (OAH) forming residues; other site 1245469007200 trimer interface [polypeptide binding]; other site 1245469007201 Predicted membrane protein [Function unknown]; Region: COG2311 1245469007202 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1245469007203 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1245469007204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469007205 Coenzyme A binding pocket [chemical binding]; other site 1245469007206 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1245469007207 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469007208 active site 1245469007209 short chain dehydrogenase; Provisional; Region: PRK07109 1245469007210 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1245469007211 putative NAD(P) binding site [chemical binding]; other site 1245469007212 active site 1245469007213 Domain of unknown function (DUF336); Region: DUF336; cl01249 1245469007214 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1245469007215 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469007216 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1245469007217 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469007218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469007219 DNA-binding site [nucleotide binding]; DNA binding site 1245469007220 FCD domain; Region: FCD; pfam07729 1245469007221 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1245469007222 homodimer interface [polypeptide binding]; other site 1245469007223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007224 catalytic residue [active] 1245469007225 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 1245469007226 homodimer interface [polypeptide binding]; other site 1245469007227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007228 catalytic residue [active] 1245469007229 enoyl-CoA hydratase; Provisional; Region: PRK06144 1245469007230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469007231 substrate binding site [chemical binding]; other site 1245469007232 oxyanion hole (OAH) forming residues; other site 1245469007233 trimer interface [polypeptide binding]; other site 1245469007234 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1245469007235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469007236 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1245469007237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1245469007238 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1245469007239 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1245469007240 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 1245469007241 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1245469007242 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469007243 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469007244 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469007245 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1245469007246 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469007247 acyl-activating enzyme (AAE) consensus motif; other site 1245469007248 active site 1245469007249 AMP binding site [chemical binding]; other site 1245469007250 CoA binding site [chemical binding]; other site 1245469007251 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469007252 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469007253 Walker A/P-loop; other site 1245469007254 ATP binding site [chemical binding]; other site 1245469007255 Q-loop/lid; other site 1245469007256 ABC transporter signature motif; other site 1245469007257 Walker B; other site 1245469007258 D-loop; other site 1245469007259 H-loop/switch region; other site 1245469007260 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1245469007261 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469007262 putative ligand binding site [chemical binding]; other site 1245469007263 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469007264 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469007265 TM-ABC transporter signature motif; other site 1245469007266 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469007267 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469007268 TM-ABC transporter signature motif; other site 1245469007269 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1245469007270 putative active site [active] 1245469007271 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1245469007272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469007273 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1245469007274 acyl-activating enzyme (AAE) consensus motif; other site 1245469007275 putative AMP binding site [chemical binding]; other site 1245469007276 putative active site [active] 1245469007277 putative CoA binding site [chemical binding]; other site 1245469007278 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469007279 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469007280 Walker A/P-loop; other site 1245469007281 ATP binding site [chemical binding]; other site 1245469007282 Q-loop/lid; other site 1245469007283 ABC transporter signature motif; other site 1245469007284 Walker B; other site 1245469007285 D-loop; other site 1245469007286 H-loop/switch region; other site 1245469007287 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469007288 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469007289 ligand binding site [chemical binding]; other site 1245469007290 flexible hinge region; other site 1245469007291 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469007292 putative switch regulator; other site 1245469007293 non-specific DNA interactions [nucleotide binding]; other site 1245469007294 DNA binding site [nucleotide binding] 1245469007295 sequence specific DNA binding site [nucleotide binding]; other site 1245469007296 putative cAMP binding site [chemical binding]; other site 1245469007297 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1245469007298 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1245469007299 NADP binding site [chemical binding]; other site 1245469007300 active site 1245469007301 putative substrate binding site [chemical binding]; other site 1245469007302 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1245469007303 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1245469007304 active site 1245469007305 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1245469007306 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1245469007307 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1245469007308 putative active site [active] 1245469007309 putative substrate binding site [chemical binding]; other site 1245469007310 putative cosubstrate binding site; other site 1245469007311 catalytic site [active] 1245469007312 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469007313 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1245469007314 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469007315 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469007316 TM-ABC transporter signature motif; other site 1245469007317 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469007318 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469007319 TM-ABC transporter signature motif; other site 1245469007320 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469007321 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469007322 Walker A/P-loop; other site 1245469007323 ATP binding site [chemical binding]; other site 1245469007324 Q-loop/lid; other site 1245469007325 ABC transporter signature motif; other site 1245469007326 Walker B; other site 1245469007327 D-loop; other site 1245469007328 H-loop/switch region; other site 1245469007329 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469007330 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469007331 Walker A/P-loop; other site 1245469007332 ATP binding site [chemical binding]; other site 1245469007333 Q-loop/lid; other site 1245469007334 ABC transporter signature motif; other site 1245469007335 Walker B; other site 1245469007336 D-loop; other site 1245469007337 H-loop/switch region; other site 1245469007338 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1245469007339 substrate binding site [chemical binding]; other site 1245469007340 THF binding site; other site 1245469007341 zinc-binding site [ion binding]; other site 1245469007342 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469007343 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1245469007344 active site 1245469007345 catalytic triad [active] 1245469007346 oxyanion hole [active] 1245469007347 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469007348 TPR repeat; Region: TPR_11; pfam13414 1245469007349 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007350 binding surface 1245469007351 TPR repeat; Region: TPR_11; pfam13414 1245469007352 TPR motif; other site 1245469007353 TPR repeat; Region: TPR_11; pfam13414 1245469007354 Caspase domain; Region: Peptidase_C14; pfam00656 1245469007355 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007356 binding surface 1245469007357 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469007358 TPR motif; other site 1245469007359 TPR repeat; Region: TPR_11; pfam13414 1245469007360 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1245469007361 catalytic motif [active] 1245469007362 Catalytic residue [active] 1245469007363 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1245469007364 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1245469007365 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1245469007366 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1245469007367 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1245469007368 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1245469007369 homotetramer interface [polypeptide binding]; other site 1245469007370 ligand binding site [chemical binding]; other site 1245469007371 catalytic site [active] 1245469007372 NAD binding site [chemical binding]; other site 1245469007373 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1245469007374 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 1245469007375 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1245469007376 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1245469007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1245469007378 AAA domain; Region: AAA_33; pfam13671 1245469007379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469007380 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1245469007381 catalytic site [active] 1245469007382 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 1245469007383 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1245469007384 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1245469007385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1245469007386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469007387 MarR family; Region: MarR; pfam01047 1245469007388 MarR family; Region: MarR_2; cl17246 1245469007389 phenol 2-monooxygenase; Provisional; Region: PRK08294 1245469007390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469007391 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 1245469007392 dimer interface [polypeptide binding]; other site 1245469007393 PilZ domain; Region: PilZ; cl01260 1245469007394 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469007395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007396 binding surface 1245469007397 TPR motif; other site 1245469007398 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469007399 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 1245469007400 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1245469007401 Type IV pili component [Cell motility and secretion]; Region: COG5461 1245469007402 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1245469007403 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1245469007404 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1245469007405 BON domain; Region: BON; pfam04972 1245469007406 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469007407 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1245469007408 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1245469007409 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 1245469007410 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469007411 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469007412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1245469007413 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469007414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469007415 Walker A/P-loop; other site 1245469007416 ATP binding site [chemical binding]; other site 1245469007417 Q-loop/lid; other site 1245469007418 ABC transporter signature motif; other site 1245469007419 Walker B; other site 1245469007420 D-loop; other site 1245469007421 H-loop/switch region; other site 1245469007422 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1245469007423 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1245469007424 NAD binding site [chemical binding]; other site 1245469007425 homodimer interface [polypeptide binding]; other site 1245469007426 active site 1245469007427 substrate binding site [chemical binding]; other site 1245469007428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469007429 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1245469007430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469007431 active site 1245469007432 motif I; other site 1245469007433 motif II; other site 1245469007434 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1245469007435 dimer interface [polypeptide binding]; other site 1245469007436 active site 1245469007437 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1245469007438 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1245469007439 putative active site [active] 1245469007440 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1245469007441 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1245469007442 NADP binding site [chemical binding]; other site 1245469007443 homopentamer interface [polypeptide binding]; other site 1245469007444 substrate binding site [chemical binding]; other site 1245469007445 active site 1245469007446 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1245469007447 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1245469007448 putative ribose interaction site [chemical binding]; other site 1245469007449 putative ADP binding site [chemical binding]; other site 1245469007450 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469007451 active site 1245469007452 HIGH motif; other site 1245469007453 nucleotide binding site [chemical binding]; other site 1245469007454 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1245469007455 O-Antigen ligase; Region: Wzy_C; pfam04932 1245469007456 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1245469007457 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1245469007458 NAD(P) binding site [chemical binding]; other site 1245469007459 homodimer interface [polypeptide binding]; other site 1245469007460 substrate binding site [chemical binding]; other site 1245469007461 active site 1245469007462 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1245469007463 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 1245469007464 Mg++ binding site [ion binding]; other site 1245469007465 putative catalytic motif [active] 1245469007466 putative substrate binding site [chemical binding]; other site 1245469007467 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1245469007468 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469007469 putative ADP-binding pocket [chemical binding]; other site 1245469007470 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469007471 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469007472 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469007473 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469007474 TPR repeat; Region: TPR_11; pfam13414 1245469007475 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1245469007476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1245469007477 active site 1245469007478 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1245469007479 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1245469007480 Walker A/P-loop; other site 1245469007481 ATP binding site [chemical binding]; other site 1245469007482 Q-loop/lid; other site 1245469007483 ABC transporter signature motif; other site 1245469007484 Walker B; other site 1245469007485 D-loop; other site 1245469007486 H-loop/switch region; other site 1245469007487 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1245469007488 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1245469007489 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1245469007490 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469007491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469007492 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1245469007493 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469007494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469007495 NAD(P) binding site [chemical binding]; other site 1245469007496 active site 1245469007497 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1245469007498 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1245469007499 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469007500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469007501 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1245469007502 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1245469007503 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1245469007504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469007505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469007506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469007507 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1245469007508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469007509 S-adenosylmethionine binding site [chemical binding]; other site 1245469007510 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469007511 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1245469007512 active site 1245469007513 ATP binding site [chemical binding]; other site 1245469007514 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1245469007515 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1245469007516 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469007517 NAD(P) binding site [chemical binding]; other site 1245469007518 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1245469007519 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1245469007520 PYR/PP interface [polypeptide binding]; other site 1245469007521 dimer interface [polypeptide binding]; other site 1245469007522 TPP binding site [chemical binding]; other site 1245469007523 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1245469007524 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1245469007525 TPP-binding site [chemical binding]; other site 1245469007526 dimer interface [polypeptide binding]; other site 1245469007527 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469007528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469007529 NAD(P) binding site [chemical binding]; other site 1245469007530 active site 1245469007531 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1245469007532 dimer interface [polypeptide binding]; other site 1245469007533 active site 1245469007534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469007535 extended (e) SDRs; Region: SDR_e; cd08946 1245469007536 NAD(P) binding site [chemical binding]; other site 1245469007537 active site 1245469007538 substrate binding site [chemical binding]; other site 1245469007539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469007540 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1245469007541 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1245469007542 active site 1245469007543 Substrate binding site; other site 1245469007544 Mg++ binding site; other site 1245469007545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469007546 active site 1245469007547 nucleotide binding site [chemical binding]; other site 1245469007548 HIGH motif; other site 1245469007549 KMSKS motif; other site 1245469007550 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1245469007551 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1245469007552 putative ribose interaction site [chemical binding]; other site 1245469007553 putative ADP binding site [chemical binding]; other site 1245469007554 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1245469007555 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1245469007556 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1245469007557 active site 1245469007558 dimer interface [polypeptide binding]; other site 1245469007559 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1245469007560 Ligand Binding Site [chemical binding]; other site 1245469007561 Molecular Tunnel; other site 1245469007562 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1245469007563 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1245469007564 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1245469007565 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1245469007566 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469007567 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1245469007568 putative NAD(P) binding site [chemical binding]; other site 1245469007569 active site 1245469007570 putative substrate binding site [chemical binding]; other site 1245469007571 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1245469007572 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1245469007573 Substrate binding site; other site 1245469007574 Cupin domain; Region: Cupin_2; cl17218 1245469007575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007576 binding surface 1245469007577 TPR motif; other site 1245469007578 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469007579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007580 binding surface 1245469007581 TPR motif; other site 1245469007582 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007583 binding surface 1245469007584 TPR motif; other site 1245469007585 TPR repeat; Region: TPR_11; pfam13414 1245469007586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007587 binding surface 1245469007588 TPR motif; other site 1245469007589 TPR repeat; Region: TPR_11; pfam13414 1245469007590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007591 binding surface 1245469007592 TPR motif; other site 1245469007593 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469007594 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469007595 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007596 TPR motif; other site 1245469007597 binding surface 1245469007598 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469007599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007600 binding surface 1245469007601 TPR motif; other site 1245469007602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007603 binding surface 1245469007604 TPR motif; other site 1245469007605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007606 binding surface 1245469007607 TPR motif; other site 1245469007608 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469007609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007610 binding surface 1245469007611 TPR motif; other site 1245469007612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007613 binding surface 1245469007614 TPR motif; other site 1245469007615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469007616 binding surface 1245469007617 TPR motif; other site 1245469007618 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 1245469007619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1245469007620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469007621 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1245469007622 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1245469007623 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1245469007624 inhibitor-cofactor binding pocket; inhibition site 1245469007625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007626 catalytic residue [active] 1245469007627 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1245469007628 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1245469007629 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469007630 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469007631 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469007632 Cytochrome C' Region: Cytochrom_C_2; pfam01322 1245469007633 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469007634 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469007635 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469007636 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469007637 putative ligand binding site [chemical binding]; other site 1245469007638 CHASE domain; Region: CHASE; pfam03924 1245469007639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469007640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469007641 metal binding site [ion binding]; metal-binding site 1245469007642 active site 1245469007643 I-site; other site 1245469007644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469007645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469007646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469007647 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469007648 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469007649 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1245469007650 dimer interface [polypeptide binding]; other site 1245469007651 substrate binding site [chemical binding]; other site 1245469007652 ATP binding site [chemical binding]; other site 1245469007653 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1245469007654 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1245469007655 SurA N-terminal domain; Region: SurA_N; pfam09312 1245469007656 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469007657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469007658 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469007659 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469007660 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469007661 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469007662 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1245469007663 catalytic triad [active] 1245469007664 dimer interface [polypeptide binding]; other site 1245469007665 conserved cis-peptide bond; other site 1245469007666 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1245469007667 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1245469007668 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1245469007669 active site 1245469007670 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 1245469007671 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1245469007672 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1245469007673 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469007674 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469007675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469007676 D-galactonate transporter; Region: 2A0114; TIGR00893 1245469007677 putative substrate translocation pore; other site 1245469007678 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1245469007679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469007680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1245469007681 active site 1245469007682 metal binding site [ion binding]; metal-binding site 1245469007683 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 1245469007684 C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239 1245469007685 putative active site [active] 1245469007686 Mn binding site [ion binding]; other site 1245469007687 putative oligomer interface [polypeptide binding]; other site 1245469007688 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469007689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469007690 DNA-binding site [nucleotide binding]; DNA binding site 1245469007691 FCD domain; Region: FCD; pfam07729 1245469007692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469007693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469007694 CHRD domain; Region: CHRD; pfam07452 1245469007695 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1245469007696 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1245469007697 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469007698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1245469007699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469007700 dimerization interface [polypeptide binding]; other site 1245469007701 putative DNA binding site [nucleotide binding]; other site 1245469007702 putative Zn2+ binding site [ion binding]; other site 1245469007703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469007704 putative DNA binding site [nucleotide binding]; other site 1245469007705 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1245469007706 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1245469007707 active site 1245469007708 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1245469007709 Sodium Bile acid symporter family; Region: SBF; cl17470 1245469007710 Predicted membrane protein [Function unknown]; Region: COG3212 1245469007711 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1245469007712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469007713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469007714 active site 1245469007715 phosphorylation site [posttranslational modification] 1245469007716 intermolecular recognition site; other site 1245469007717 dimerization interface [polypeptide binding]; other site 1245469007718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469007719 DNA binding site [nucleotide binding] 1245469007720 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1245469007721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1245469007722 dimer interface [polypeptide binding]; other site 1245469007723 phosphorylation site [posttranslational modification] 1245469007724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469007725 ATP binding site [chemical binding]; other site 1245469007726 Mg2+ binding site [ion binding]; other site 1245469007727 G-X-G motif; other site 1245469007728 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1245469007729 CCC1; Region: CCC1; cd02435 1245469007730 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 1245469007731 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1245469007732 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1245469007733 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1245469007734 active site 1245469007735 catalytic site [active] 1245469007736 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1245469007737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469007738 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1245469007739 dimerization interface [polypeptide binding]; other site 1245469007740 substrate binding pocket [chemical binding]; other site 1245469007741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469007742 D-galactonate transporter; Region: 2A0114; TIGR00893 1245469007743 putative substrate translocation pore; other site 1245469007744 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1245469007745 tartrate dehydrogenase; Region: TTC; TIGR02089 1245469007746 pyruvate kinase; Provisional; Region: PRK06247 1245469007747 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1245469007748 domain interfaces; other site 1245469007749 active site 1245469007750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469007751 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1245469007752 putative active site [active] 1245469007753 putative metal binding site [ion binding]; other site 1245469007754 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1245469007755 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1245469007756 tetramer interface [polypeptide binding]; other site 1245469007757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007758 catalytic residue [active] 1245469007759 Caspase domain; Region: Peptidase_C14; pfam00656 1245469007760 substrate pocket [chemical binding]; other site 1245469007761 active site 1245469007762 proteolytic cleavage site; other site 1245469007763 dimer interface [polypeptide binding]; other site 1245469007764 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1245469007765 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1245469007766 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1245469007767 active site 1245469007768 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1245469007769 Permease; Region: Permease; pfam02405 1245469007770 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1245469007771 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1245469007772 Walker A/P-loop; other site 1245469007773 ATP binding site [chemical binding]; other site 1245469007774 Q-loop/lid; other site 1245469007775 ABC transporter signature motif; other site 1245469007776 Walker B; other site 1245469007777 D-loop; other site 1245469007778 H-loop/switch region; other site 1245469007779 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1245469007780 mce related protein; Region: MCE; pfam02470 1245469007781 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1245469007782 putative binding surface; other site 1245469007783 active site 1245469007784 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469007785 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469007786 catalytic loop [active] 1245469007787 iron binding site [ion binding]; other site 1245469007788 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1245469007789 active site 1245469007790 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1245469007791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469007792 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469007793 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1245469007794 active site 1245469007795 oxyanion hole [active] 1245469007796 Predicted integral membrane protein [Function unknown]; Region: COG0392 1245469007797 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1245469007798 dimerization interface [polypeptide binding]; other site 1245469007799 metal binding site [ion binding]; metal-binding site 1245469007800 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469007801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469007802 putative substrate translocation pore; other site 1245469007803 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1245469007804 putative active site [active] 1245469007805 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469007806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469007807 S-adenosylmethionine binding site [chemical binding]; other site 1245469007808 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1245469007809 Ligand Binding Site [chemical binding]; other site 1245469007810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1245469007811 catalytic core [active] 1245469007812 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1245469007813 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469007814 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1245469007815 SelR domain; Region: SelR; pfam01641 1245469007816 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 1245469007817 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1245469007818 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1245469007819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1245469007820 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1245469007821 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1245469007822 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1245469007823 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 1245469007824 flagellin; Provisional; Region: PRK14708 1245469007825 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 1245469007826 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469007827 tyrosine decarboxylase; Region: PLN02880 1245469007828 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1245469007829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007830 catalytic residue [active] 1245469007831 flagellin; Reviewed; Region: PRK12688 1245469007832 flagellin; Reviewed; Region: PRK12688 1245469007833 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK12791 1245469007834 flagellin; Reviewed; Region: PRK12688 1245469007835 flagellin; Reviewed; Region: PRK12688 1245469007836 flagellin; Reviewed; Region: PRK12688 1245469007837 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 1245469007838 chemotactic signal-response protein CheL; Provisional; Region: PRK12790 1245469007839 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1245469007840 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1245469007841 flagellar assembly regulator FliX; Reviewed; Region: fliX; PRK12787 1245469007842 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469007843 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469007844 dimerization interface [polypeptide binding]; other site 1245469007845 putative DNA binding site [nucleotide binding]; other site 1245469007846 putative Zn2+ binding site [ion binding]; other site 1245469007847 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1245469007848 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1245469007849 NAD binding site [chemical binding]; other site 1245469007850 substrate binding site [chemical binding]; other site 1245469007851 putative active site [active] 1245469007852 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1245469007853 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469007854 PAS fold; Region: PAS_3; pfam08447 1245469007855 putative active site [active] 1245469007856 heme pocket [chemical binding]; other site 1245469007857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469007858 HWE histidine kinase; Region: HWE_HK; pfam07536 1245469007859 cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662 1245469007860 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 1245469007861 NADP binding site [chemical binding]; other site 1245469007862 putative substrate binding site [chemical binding]; other site 1245469007863 active site 1245469007864 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1245469007865 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1245469007866 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1245469007867 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK12786 1245469007868 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1245469007869 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 1245469007870 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1245469007871 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1245469007872 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689 1245469007873 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1245469007874 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK12785 1245469007875 flagellar motor switch protein FliM; Reviewed; Region: fliM; PRK12795 1245469007876 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1245469007877 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1245469007878 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469007879 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1245469007880 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1245469007881 DNA binding residues [nucleotide binding] 1245469007882 dimer interface [polypeptide binding]; other site 1245469007883 putative metal binding site [ion binding]; other site 1245469007884 Cation efflux family; Region: Cation_efflux; cl00316 1245469007885 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1245469007886 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004 1245469007887 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1245469007888 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1245469007889 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1245469007890 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1245469007891 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00732 1245469007892 flagellar biosynthesis protein FliQ; Reviewed; Region: fliQ; PRK06010 1245469007893 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1245469007894 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1245469007895 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1245469007896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469007897 PAS domain; Region: PAS_9; pfam13426 1245469007898 putative active site [active] 1245469007899 heme pocket [chemical binding]; other site 1245469007900 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1245469007901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469007902 dimer interface [polypeptide binding]; other site 1245469007903 phosphorylation site [posttranslational modification] 1245469007904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469007905 ATP binding site [chemical binding]; other site 1245469007906 Mg2+ binding site [ion binding]; other site 1245469007907 G-X-G motif; other site 1245469007908 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469007909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469007910 active site 1245469007911 phosphorylation site [posttranslational modification] 1245469007912 intermolecular recognition site; other site 1245469007913 dimerization interface [polypeptide binding]; other site 1245469007914 Tim44-like domain; Region: Tim44; pfam04280 1245469007915 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469007916 glutathione s-transferase; Provisional; Region: PTZ00057 1245469007917 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 1245469007918 N-terminal domain interface [polypeptide binding]; other site 1245469007919 dimer interface [polypeptide binding]; other site 1245469007920 substrate binding pocket (H-site) [chemical binding]; other site 1245469007921 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 1245469007922 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469007923 fumarate hydratase; Provisional; Region: PRK15389 1245469007924 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1245469007925 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1245469007926 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1245469007927 putative active site [active] 1245469007928 putative catalytic site [active] 1245469007929 Protein of unknown function (DUF429); Region: DUF429; pfam04250 1245469007930 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1245469007931 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1245469007932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469007933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469007934 WHG domain; Region: WHG; pfam13305 1245469007935 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1245469007936 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469007938 S-adenosylmethionine binding site [chemical binding]; other site 1245469007939 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469007940 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469007941 non-specific DNA binding site [nucleotide binding]; other site 1245469007942 salt bridge; other site 1245469007943 sequence-specific DNA binding site [nucleotide binding]; other site 1245469007944 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1245469007945 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1245469007946 catalytic residues [active] 1245469007947 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1245469007948 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469007949 Zn2+ binding site [ion binding]; other site 1245469007950 Mg2+ binding site [ion binding]; other site 1245469007951 Caspase domain; Region: Peptidase_C14; pfam00656 1245469007952 active site 1245469007953 substrate pocket [chemical binding]; other site 1245469007954 dimer interface [polypeptide binding]; other site 1245469007955 proteolytic cleavage site; other site 1245469007956 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1245469007957 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469007958 Trp docking motif [polypeptide binding]; other site 1245469007959 putative active site [active] 1245469007960 PilZ domain; Region: PilZ; pfam07238 1245469007961 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469007962 CoenzymeA binding site [chemical binding]; other site 1245469007963 subunit interaction site [polypeptide binding]; other site 1245469007964 PHB binding site; other site 1245469007965 recombinase A; Provisional; Region: recA; PRK09354 1245469007966 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1245469007967 hexamer interface [polypeptide binding]; other site 1245469007968 Walker A motif; other site 1245469007969 ATP binding site [chemical binding]; other site 1245469007970 Walker B motif; other site 1245469007971 glycine dehydrogenase; Provisional; Region: PRK05367 1245469007972 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1245469007973 tetramer interface [polypeptide binding]; other site 1245469007974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007975 catalytic residue [active] 1245469007976 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1245469007977 tetramer interface [polypeptide binding]; other site 1245469007978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469007979 catalytic residue [active] 1245469007980 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1245469007981 lipoyl attachment site [posttranslational modification]; other site 1245469007982 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 1245469007983 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1245469007984 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1245469007985 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1245469007986 motif 1; other site 1245469007987 active site 1245469007988 motif 2; other site 1245469007989 motif 3; other site 1245469007990 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1245469007991 DHHA1 domain; Region: DHHA1; pfam02272 1245469007992 Ion transport protein; Region: Ion_trans; pfam00520 1245469007993 Ion channel; Region: Ion_trans_2; pfam07885 1245469007994 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469007995 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469007996 ligand binding site [chemical binding]; other site 1245469007997 flexible hinge region; other site 1245469007998 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 1245469007999 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1245469008000 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1245469008001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469008002 catalytic loop [active] 1245469008003 iron binding site [ion binding]; other site 1245469008004 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1245469008005 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1245469008006 [4Fe-4S] binding site [ion binding]; other site 1245469008007 molybdopterin cofactor binding site; other site 1245469008008 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1245469008009 molybdopterin cofactor binding site; other site 1245469008010 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 1245469008011 putative dimer interface [polypeptide binding]; other site 1245469008012 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1245469008013 SLBB domain; Region: SLBB; pfam10531 1245469008014 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1245469008015 formate dehydrogenase subunit gamma; Validated; Region: PRK05988 1245469008016 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469008017 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469008018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469008019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1245469008020 dimerization interface [polypeptide binding]; other site 1245469008021 Phospholipid methyltransferase; Region: PEMT; cl17370 1245469008022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469008023 PAS fold; Region: PAS_3; pfam08447 1245469008024 putative active site [active] 1245469008025 heme pocket [chemical binding]; other site 1245469008026 PAS fold; Region: PAS_7; pfam12860 1245469008027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469008028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469008029 dimer interface [polypeptide binding]; other site 1245469008030 phosphorylation site [posttranslational modification] 1245469008031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469008032 ATP binding site [chemical binding]; other site 1245469008033 Mg2+ binding site [ion binding]; other site 1245469008034 G-X-G motif; other site 1245469008035 Cation efflux family; Region: Cation_efflux; cl00316 1245469008036 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1245469008037 Cation efflux family; Region: Cation_efflux; cl00316 1245469008038 Cation efflux family; Region: Cation_efflux; cl00316 1245469008039 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469008040 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1245469008041 NAD(P) binding site [chemical binding]; other site 1245469008042 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469008043 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1245469008044 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1245469008045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469008046 putative substrate translocation pore; other site 1245469008047 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 1245469008048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469008049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469008050 putative substrate translocation pore; other site 1245469008051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1245469008052 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1245469008053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469008054 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469008055 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469008056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469008057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469008058 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1245469008059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469008060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469008061 DNA binding site [nucleotide binding] 1245469008062 Predicted integral membrane protein [Function unknown]; Region: COG5616 1245469008063 TPR repeat; Region: TPR_11; pfam13414 1245469008064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469008065 TPR motif; other site 1245469008066 binding surface 1245469008067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469008068 binding surface 1245469008069 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469008070 TPR motif; other site 1245469008071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469008072 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1245469008073 NAD(P) binding site [chemical binding]; other site 1245469008074 active site 1245469008075 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469008076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469008077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469008078 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469008079 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469008080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469008081 NAD(P) binding site [chemical binding]; other site 1245469008082 active site 1245469008083 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469008084 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469008085 Cupin domain; Region: Cupin_2; pfam07883 1245469008086 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1245469008087 hypothetical protein; Provisional; Region: PRK06847 1245469008088 hypothetical protein; Provisional; Region: PRK07236 1245469008089 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1245469008090 iron-sulfur cluster [ion binding]; other site 1245469008091 [2Fe-2S] cluster binding site [ion binding]; other site 1245469008092 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 1245469008093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469008094 putative active site [active] 1245469008095 putative metal binding site [ion binding]; other site 1245469008096 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469008097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469008098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469008099 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1245469008100 putative substrate binding pocket [chemical binding]; other site 1245469008101 putative dimerization interface [polypeptide binding]; other site 1245469008102 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1245469008103 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1245469008104 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1245469008105 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469008106 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1245469008107 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469008108 PYR/PP interface [polypeptide binding]; other site 1245469008109 dimer interface [polypeptide binding]; other site 1245469008110 TPP binding site [chemical binding]; other site 1245469008111 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469008112 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1245469008113 TPP-binding site; other site 1245469008114 dimer interface [polypeptide binding]; other site 1245469008115 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469008116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469008117 DNA-binding site [nucleotide binding]; DNA binding site 1245469008118 FCD domain; Region: FCD; pfam07729 1245469008119 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1245469008120 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1245469008121 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1245469008122 CoA binding domain; Region: CoA_binding_2; pfam13380 1245469008123 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1245469008124 transcriptional repressor IclR; Provisional; Region: PRK11569 1245469008125 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1245469008126 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469008127 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1245469008128 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469008129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469008130 active site 1245469008131 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1245469008132 glyoxylate carboligase; Provisional; Region: PRK11269 1245469008133 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469008134 PYR/PP interface [polypeptide binding]; other site 1245469008135 dimer interface [polypeptide binding]; other site 1245469008136 TPP binding site [chemical binding]; other site 1245469008137 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469008138 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1245469008139 TPP-binding site [chemical binding]; other site 1245469008140 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1245469008141 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1245469008142 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1245469008143 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 1245469008144 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1245469008145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469008146 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 1245469008147 putative dimerization interface [polypeptide binding]; other site 1245469008148 putative substrate binding pocket [chemical binding]; other site 1245469008149 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469008150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469008151 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469008152 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1245469008153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469008154 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1245469008155 VanZ like family; Region: VanZ; cl01971 1245469008156 hypothetical protein; Provisional; Region: PRK06163 1245469008157 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 1245469008158 TPP-binding site; other site 1245469008159 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469008160 PYR/PP interface [polypeptide binding]; other site 1245469008161 dimer interface [polypeptide binding]; other site 1245469008162 TPP binding site [chemical binding]; other site 1245469008163 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469008164 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1245469008165 ligand binding site [chemical binding]; other site 1245469008166 NAD binding site [chemical binding]; other site 1245469008167 dimerization interface [polypeptide binding]; other site 1245469008168 catalytic site [active] 1245469008169 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1245469008170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469008171 Coenzyme A binding pocket [chemical binding]; other site 1245469008172 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1245469008173 ornithine decarboxylase; Provisional; Region: PRK13578 1245469008174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469008175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469008176 catalytic residue [active] 1245469008177 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1245469008178 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1245469008179 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1245469008180 putative dimer interface [polypeptide binding]; other site 1245469008181 active site pocket [active] 1245469008182 putative cataytic base [active] 1245469008183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1245469008184 catalytic core [active] 1245469008185 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1245469008186 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1245469008187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469008188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469008189 homodimer interface [polypeptide binding]; other site 1245469008190 catalytic residue [active] 1245469008191 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1245469008192 cobyric acid synthase; Provisional; Region: PRK00784 1245469008193 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469008194 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1245469008195 catalytic triad [active] 1245469008196 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1245469008197 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1245469008198 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1245469008199 homodimer interface [polypeptide binding]; other site 1245469008200 Walker A motif; other site 1245469008201 ATP binding site [chemical binding]; other site 1245469008202 hydroxycobalamin binding site [chemical binding]; other site 1245469008203 Walker B motif; other site 1245469008204 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1245469008205 homotrimer interface [polypeptide binding]; other site 1245469008206 Walker A motif; other site 1245469008207 GTP binding site [chemical binding]; other site 1245469008208 Walker B motif; other site 1245469008209 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 1245469008210 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 1245469008211 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1245469008212 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1245469008213 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 1245469008214 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1245469008215 precorrin-3B synthase; Region: CobG; TIGR02435 1245469008216 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1245469008217 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1245469008218 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1245469008219 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1245469008220 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1245469008221 active site 1245469008222 SAM binding site [chemical binding]; other site 1245469008223 homodimer interface [polypeptide binding]; other site 1245469008224 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1245469008225 active site 1245469008226 SAM binding site [chemical binding]; other site 1245469008227 homodimer interface [polypeptide binding]; other site 1245469008228 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1245469008229 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1245469008230 active site 1245469008231 putative homodimer interface [polypeptide binding]; other site 1245469008232 SAM binding site [chemical binding]; other site 1245469008233 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1245469008234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469008235 S-adenosylmethionine binding site [chemical binding]; other site 1245469008236 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1245469008237 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1245469008238 active site 1245469008239 SAM binding site [chemical binding]; other site 1245469008240 homodimer interface [polypeptide binding]; other site 1245469008241 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1245469008242 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1245469008243 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1245469008244 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1245469008245 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1245469008246 putative FMN binding site [chemical binding]; other site 1245469008247 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1245469008248 active site 1245469008249 cosubstrate binding site; other site 1245469008250 substrate binding site [chemical binding]; other site 1245469008251 catalytic site [active] 1245469008252 RNA polymerase sigma factor; Provisional; Region: PRK12538 1245469008253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469008254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469008255 DNA binding residues [nucleotide binding] 1245469008256 flagellin; Provisional; Region: PRK12807 1245469008257 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1245469008258 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1245469008259 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1245469008260 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1245469008261 Flagellar protein FliS; Region: FliS; cl00654 1245469008262 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1245469008263 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1245469008264 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1245469008265 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1245469008266 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1245469008267 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1245469008268 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08913 1245469008269 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1245469008270 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1245469008271 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1245469008272 short chain dehydrogenase; Provisional; Region: PRK06139 1245469008273 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1245469008274 putative NAD(P) binding site [chemical binding]; other site 1245469008275 active site 1245469008276 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1245469008277 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1245469008278 D-pathway; other site 1245469008279 Putative ubiquinol binding site [chemical binding]; other site 1245469008280 Low-spin heme (heme b) binding site [chemical binding]; other site 1245469008281 Putative water exit pathway; other site 1245469008282 Binuclear center (heme o3/CuB) [ion binding]; other site 1245469008283 K-pathway; other site 1245469008284 Putative proton exit pathway; other site 1245469008285 BA14K-like protein; Region: BA14K; pfam07886 1245469008286 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469008287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469008288 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1245469008289 catalytic site [active] 1245469008290 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 1245469008291 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1245469008292 homodimer interface [polypeptide binding]; other site 1245469008293 substrate-cofactor binding pocket; other site 1245469008294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469008295 catalytic residue [active] 1245469008296 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1245469008297 putative FMN binding site [chemical binding]; other site 1245469008298 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469008299 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469008300 substrate binding pocket [chemical binding]; other site 1245469008301 membrane-bound complex binding site; other site 1245469008302 hinge residues; other site 1245469008303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469008304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469008305 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1245469008306 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1245469008307 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1245469008308 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1245469008309 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1245469008310 active site 1245469008311 non-prolyl cis peptide bond; other site 1245469008312 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1245469008313 PRC-barrel domain; Region: PRC; pfam05239 1245469008314 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 1245469008315 nudix motif; other site 1245469008316 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 1245469008317 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469008318 ligand binding site [chemical binding]; other site 1245469008319 regulator interaction site; other site 1245469008320 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1245469008321 ANTAR domain; Region: ANTAR; cl04297 1245469008322 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469008323 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 1245469008324 putative ligand binding site [chemical binding]; other site 1245469008325 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469008326 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469008327 TM-ABC transporter signature motif; other site 1245469008328 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469008329 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469008330 TM-ABC transporter signature motif; other site 1245469008331 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1245469008332 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469008333 Walker A/P-loop; other site 1245469008334 ATP binding site [chemical binding]; other site 1245469008335 Q-loop/lid; other site 1245469008336 ABC transporter signature motif; other site 1245469008337 Walker B; other site 1245469008338 D-loop; other site 1245469008339 H-loop/switch region; other site 1245469008340 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469008341 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469008342 Walker A/P-loop; other site 1245469008343 ATP binding site [chemical binding]; other site 1245469008344 Q-loop/lid; other site 1245469008345 ABC transporter signature motif; other site 1245469008346 Walker B; other site 1245469008347 D-loop; other site 1245469008348 H-loop/switch region; other site 1245469008349 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1245469008350 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469008351 First nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R1; cd07578 1245469008352 putative active site [active] 1245469008353 catalytic triad [active] 1245469008354 putative dimer interface [polypeptide binding]; other site 1245469008355 Second nitrilase domain of an uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_1_R2; cd07579 1245469008356 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469008357 putative active site [active] 1245469008358 catalytic triad [active] 1245469008359 putative dimer interface [polypeptide binding]; other site 1245469008360 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 1245469008361 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1245469008362 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1245469008363 SLBB domain; Region: SLBB; pfam10531 1245469008364 H-NS histone family; Region: Histone_HNS; pfam00816 1245469008365 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1245469008366 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1245469008367 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1245469008368 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1245469008369 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1245469008370 active site 1245469008371 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1245469008372 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1245469008373 extended (e) SDRs; Region: SDR_e; cd08946 1245469008374 NAD(P) binding site [chemical binding]; other site 1245469008375 active site 1245469008376 substrate binding site [chemical binding]; other site 1245469008377 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1245469008378 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469008379 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1245469008380 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1245469008381 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1245469008382 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469008383 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 1245469008384 metal binding site [ion binding]; metal-binding site 1245469008385 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1245469008386 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1245469008387 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1245469008388 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1245469008389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1245469008390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469008391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469008392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469008393 NAD(P) binding site [chemical binding]; other site 1245469008394 active site 1245469008395 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1245469008396 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1245469008397 active site 1245469008398 dimer interface [polypeptide binding]; other site 1245469008399 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1245469008400 Ligand Binding Site [chemical binding]; other site 1245469008401 Molecular Tunnel; other site 1245469008402 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1245469008403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469008404 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469008405 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469008406 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1245469008407 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1245469008408 DXD motif; other site 1245469008409 Right handed beta helix region; Region: Beta_helix; pfam13229 1245469008410 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1245469008411 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1245469008412 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1245469008413 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1245469008414 anti sigma factor interaction site; other site 1245469008415 regulatory phosphorylation site [posttranslational modification]; other site 1245469008416 Chain length determinant protein; Region: Wzz; pfam02706 1245469008417 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 1245469008418 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1245469008419 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1245469008420 intersubunit interface [polypeptide binding]; other site 1245469008421 active site 1245469008422 Zn2+ binding site [ion binding]; other site 1245469008423 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 1245469008424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469008425 active site 1245469008426 motif I; other site 1245469008427 motif II; other site 1245469008428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469008429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1245469008430 D-xylulose kinase; Region: XylB; TIGR01312 1245469008431 nucleotide binding site [chemical binding]; other site 1245469008432 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1245469008433 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1245469008434 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469008435 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469008436 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1245469008437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469008438 dimer interface [polypeptide binding]; other site 1245469008439 conserved gate region; other site 1245469008440 putative PBP binding loops; other site 1245469008441 ABC-ATPase subunit interface; other site 1245469008442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469008443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469008444 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469008445 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469008446 Walker A/P-loop; other site 1245469008447 ATP binding site [chemical binding]; other site 1245469008448 Q-loop/lid; other site 1245469008449 ABC transporter signature motif; other site 1245469008450 Walker B; other site 1245469008451 D-loop; other site 1245469008452 H-loop/switch region; other site 1245469008453 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469008454 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1245469008455 Walker A/P-loop; other site 1245469008456 ATP binding site [chemical binding]; other site 1245469008457 Q-loop/lid; other site 1245469008458 ABC transporter signature motif; other site 1245469008459 Walker B; other site 1245469008460 D-loop; other site 1245469008461 H-loop/switch region; other site 1245469008462 TOBE domain; Region: TOBE_2; pfam08402 1245469008463 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1245469008464 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1245469008465 putative N- and C-terminal domain interface [polypeptide binding]; other site 1245469008466 MgATP binding site [chemical binding]; other site 1245469008467 putative active site [active] 1245469008468 catalytic site [active] 1245469008469 metal binding site [ion binding]; metal-binding site 1245469008470 putative xylulose binding site [chemical binding]; other site 1245469008471 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469008472 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 1245469008473 putative ligand binding site [chemical binding]; other site 1245469008474 putative NAD binding site [chemical binding]; other site 1245469008475 catalytic site [active] 1245469008476 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1245469008477 intersubunit interface [polypeptide binding]; other site 1245469008478 active site 1245469008479 Zn2+ binding site [ion binding]; other site 1245469008480 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 1245469008481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469008482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469008483 TM-ABC transporter signature motif; other site 1245469008484 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469008485 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469008486 TM-ABC transporter signature motif; other site 1245469008487 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469008488 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469008489 Walker A/P-loop; other site 1245469008490 ATP binding site [chemical binding]; other site 1245469008491 Q-loop/lid; other site 1245469008492 ABC transporter signature motif; other site 1245469008493 Walker B; other site 1245469008494 D-loop; other site 1245469008495 H-loop/switch region; other site 1245469008496 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469008497 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1245469008498 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469008499 putative ligand binding site [chemical binding]; other site 1245469008500 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1245469008501 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1245469008502 DNA binding site [nucleotide binding] 1245469008503 domain linker motif; other site 1245469008504 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1245469008505 putative ligand binding site [chemical binding]; other site 1245469008506 putative dimerization interface [polypeptide binding]; other site 1245469008507 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469008508 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 1245469008509 putative ligand binding site [chemical binding]; other site 1245469008510 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1245469008511 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469008512 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469008513 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469008514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469008515 TM-ABC transporter signature motif; other site 1245469008516 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469008517 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469008518 TM-ABC transporter signature motif; other site 1245469008519 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469008520 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469008521 Walker A/P-loop; other site 1245469008522 ATP binding site [chemical binding]; other site 1245469008523 Q-loop/lid; other site 1245469008524 ABC transporter signature motif; other site 1245469008525 Walker B; other site 1245469008526 D-loop; other site 1245469008527 H-loop/switch region; other site 1245469008528 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469008529 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469008530 Walker A/P-loop; other site 1245469008531 ATP binding site [chemical binding]; other site 1245469008532 Q-loop/lid; other site 1245469008533 ABC transporter signature motif; other site 1245469008534 Walker B; other site 1245469008535 D-loop; other site 1245469008536 H-loop/switch region; other site 1245469008537 hypothetical protein; Provisional; Region: PRK02399 1245469008538 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 1245469008539 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 1245469008540 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1245469008541 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1245469008542 putative hydrophobic ligand binding site [chemical binding]; other site 1245469008543 protein interface [polypeptide binding]; other site 1245469008544 gate; other site 1245469008545 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1245469008546 putative hydrophobic ligand binding site [chemical binding]; other site 1245469008547 protein interface [polypeptide binding]; other site 1245469008548 gate; other site 1245469008549 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469008550 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1245469008551 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469008552 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469008553 catalytic loop [active] 1245469008554 iron binding site [ion binding]; other site 1245469008555 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469008556 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469008557 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469008558 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469008559 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469008560 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469008561 MoxR-like ATPases [General function prediction only]; Region: COG0714 1245469008562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469008563 ATP binding site [chemical binding]; other site 1245469008564 Walker A motif; other site 1245469008565 Walker B motif; other site 1245469008566 arginine finger; other site 1245469008567 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1245469008568 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1245469008569 metal ion-dependent adhesion site (MIDAS); other site 1245469008570 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469008571 Amidohydrolase; Region: Amidohydro_2; pfam04909 1245469008572 active site 1245469008573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1245469008574 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1245469008575 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469008576 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1245469008577 catalytic triad [active] 1245469008578 conserved cis-peptide bond; other site 1245469008579 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1245469008580 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1245469008581 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1245469008582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469008583 ATP binding site [chemical binding]; other site 1245469008584 putative Mg++ binding site [ion binding]; other site 1245469008585 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469008586 nucleotide binding region [chemical binding]; other site 1245469008587 ATP-binding site [chemical binding]; other site 1245469008588 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1245469008589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469008590 CheB methylesterase; Region: CheB_methylest; pfam01339 1245469008591 CheB methylesterase; Region: CheB_methylest; pfam01339 1245469008592 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1245469008593 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1245469008594 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1245469008595 IncA protein; Region: IncA; pfam04156 1245469008596 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1245469008597 PAS domain; Region: PAS_10; pfam13596 1245469008598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469008599 HWE histidine kinase; Region: HWE_HK; smart00911 1245469008600 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469008601 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1245469008602 ligand binding site [chemical binding]; other site 1245469008603 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469008604 non-specific DNA interactions [nucleotide binding]; other site 1245469008605 DNA binding site [nucleotide binding] 1245469008606 sequence specific DNA binding site [nucleotide binding]; other site 1245469008607 putative cAMP binding site [chemical binding]; other site 1245469008608 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1245469008609 MbtH-like protein; Region: MbtH; cl01279 1245469008610 acyl-CoA synthetase; Validated; Region: PRK05850 1245469008611 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1245469008612 acyl-activating enzyme (AAE) consensus motif; other site 1245469008613 active site 1245469008614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008615 Condensation domain; Region: Condensation; pfam00668 1245469008616 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008617 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469008618 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008619 acyl-activating enzyme (AAE) consensus motif; other site 1245469008620 AMP binding site [chemical binding]; other site 1245469008621 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1245469008622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469008623 S-adenosylmethionine binding site [chemical binding]; other site 1245469008624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469008625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008626 Condensation domain; Region: Condensation; pfam00668 1245469008627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008628 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008629 acyl-activating enzyme (AAE) consensus motif; other site 1245469008630 AMP binding site [chemical binding]; other site 1245469008631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008632 Condensation domain; Region: Condensation; pfam00668 1245469008633 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469008634 Condensation domain; Region: Condensation; pfam00668 1245469008635 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008636 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008637 acyl-activating enzyme (AAE) consensus motif; other site 1245469008638 AMP binding site [chemical binding]; other site 1245469008639 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008640 peptide synthase; Provisional; Region: PRK12467 1245469008641 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469008642 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1245469008643 acyl-activating enzyme (AAE) consensus motif; other site 1245469008644 AMP binding site [chemical binding]; other site 1245469008645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008646 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469008647 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008648 acyl-activating enzyme (AAE) consensus motif; other site 1245469008649 AMP binding site [chemical binding]; other site 1245469008650 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008651 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469008652 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008653 acyl-activating enzyme (AAE) consensus motif; other site 1245469008654 AMP binding site [chemical binding]; other site 1245469008655 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008656 Condensation domain; Region: Condensation; pfam00668 1245469008657 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008658 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469008659 Condensation domain; Region: Condensation; pfam00668 1245469008660 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008661 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008662 acyl-activating enzyme (AAE) consensus motif; other site 1245469008663 AMP binding site [chemical binding]; other site 1245469008664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008665 Condensation domain; Region: Condensation; pfam00668 1245469008666 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008667 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469008668 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008669 acyl-activating enzyme (AAE) consensus motif; other site 1245469008670 AMP binding site [chemical binding]; other site 1245469008671 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008672 Condensation domain; Region: Condensation; pfam00668 1245469008673 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008674 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469008675 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469008676 acyl-activating enzyme (AAE) consensus motif; other site 1245469008677 AMP binding site [chemical binding]; other site 1245469008678 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469008679 Condensation domain; Region: Condensation; pfam00668 1245469008680 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469008681 Condensation domain; Region: Condensation; pfam00668 1245469008682 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469008683 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1245469008684 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1245469008685 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1245469008686 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469008687 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469008688 YtkA-like; Region: YtkA; pfam13115 1245469008689 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1245469008690 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1245469008691 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469008692 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469008693 catalytic tetrad [active] 1245469008694 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1245469008695 IHF - DNA interface [nucleotide binding]; other site 1245469008696 IHF dimer interface [polypeptide binding]; other site 1245469008697 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1245469008698 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1245469008699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469008700 MarR family; Region: MarR_2; pfam12802 1245469008701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469008702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469008703 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 1245469008704 putative dimerization interface [polypeptide binding]; other site 1245469008705 tRNA dihydrouridine synthase A; Region: yjbN; TIGR00742 1245469008706 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1245469008707 FMN binding site [chemical binding]; other site 1245469008708 active site 1245469008709 catalytic residues [active] 1245469008710 substrate binding site [chemical binding]; other site 1245469008711 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1245469008712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469008713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469008714 homodimer interface [polypeptide binding]; other site 1245469008715 catalytic residue [active] 1245469008716 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1245469008717 catalytic motif [active] 1245469008718 Catalytic residue [active] 1245469008719 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 1245469008720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469008721 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469008722 dimer interface [polypeptide binding]; other site 1245469008723 phosphorylation site [posttranslational modification] 1245469008724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469008725 ATP binding site [chemical binding]; other site 1245469008726 Mg2+ binding site [ion binding]; other site 1245469008727 G-X-G motif; other site 1245469008728 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1245469008729 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1245469008730 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469008731 N-terminal plug; other site 1245469008732 ligand-binding site [chemical binding]; other site 1245469008733 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469008734 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469008735 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1245469008736 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469008737 dimer interface [polypeptide binding]; other site 1245469008738 putative metal binding site [ion binding]; other site 1245469008739 Domain of unknown function DUF59; Region: DUF59; pfam01883 1245469008740 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1245469008741 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1245469008742 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469008743 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1245469008744 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469008745 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1245469008746 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1245469008747 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 1245469008748 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1245469008749 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1245469008750 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469008751 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 1245469008752 S-adenosylmethionine binding site [chemical binding]; other site 1245469008753 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1245469008754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469008755 FeS/SAM binding site; other site 1245469008756 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1245469008757 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1245469008758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469008759 motif II; other site 1245469008760 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1245469008761 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1245469008762 active site 1245469008763 dimer interface [polypeptide binding]; other site 1245469008764 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 1245469008765 glutathione reductase; Validated; Region: PRK06116 1245469008766 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469008767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469008768 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1245469008769 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1245469008770 putative hydrophobic ligand binding site [chemical binding]; other site 1245469008771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469008772 dimerization interface [polypeptide binding]; other site 1245469008773 putative DNA binding site [nucleotide binding]; other site 1245469008774 putative Zn2+ binding site [ion binding]; other site 1245469008775 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469008776 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 1245469008777 putative sugar binding site [chemical binding]; other site 1245469008778 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1245469008779 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1245469008780 putative sugar binding sites [chemical binding]; other site 1245469008781 Q-X-W motif; other site 1245469008782 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1245469008783 SnoaL-like domain; Region: SnoaL_3; pfam13474 1245469008784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469008785 HWE histidine kinase; Region: HWE_HK; pfam07536 1245469008786 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1245469008787 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 1245469008788 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1245469008789 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1245469008790 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469008791 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1245469008792 multimer interface [polypeptide binding]; other site 1245469008793 active site 1245469008794 catalytic triad [active] 1245469008795 protein interface 1 [polypeptide binding]; other site 1245469008796 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1245469008797 Ligand Binding Site [chemical binding]; other site 1245469008798 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 1245469008799 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1245469008800 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1245469008801 active site 1245469008802 HIGH motif; other site 1245469008803 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1245469008804 KMSKS motif; other site 1245469008805 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1245469008806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1245469008807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469008808 Coenzyme A binding pocket [chemical binding]; other site 1245469008809 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1245469008810 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1245469008811 active site 1245469008812 catalytic residues [active] 1245469008813 metal binding site [ion binding]; metal-binding site 1245469008814 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1245469008815 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1245469008816 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469008817 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1245469008818 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 1245469008819 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469008820 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 1245469008821 Walker A/P-loop; other site 1245469008822 ATP binding site [chemical binding]; other site 1245469008823 Q-loop/lid; other site 1245469008824 ABC transporter signature motif; other site 1245469008825 Walker B; other site 1245469008826 D-loop; other site 1245469008827 H-loop/switch region; other site 1245469008828 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1245469008829 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1245469008830 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1245469008831 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1245469008832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469008833 dimer interface [polypeptide binding]; other site 1245469008834 phosphorylation site [posttranslational modification] 1245469008835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469008836 ATP binding site [chemical binding]; other site 1245469008837 Mg2+ binding site [ion binding]; other site 1245469008838 G-X-G motif; other site 1245469008839 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469008840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469008841 active site 1245469008842 phosphorylation site [posttranslational modification] 1245469008843 intermolecular recognition site; other site 1245469008844 dimerization interface [polypeptide binding]; other site 1245469008845 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1245469008846 putative binding surface; other site 1245469008847 active site 1245469008848 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1245469008849 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1245469008850 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1245469008851 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1245469008852 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469008853 ligand binding site [chemical binding]; other site 1245469008854 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1245469008855 potassium uptake protein; Region: kup; TIGR00794 1245469008856 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1245469008857 potassium uptake protein; Region: kup; TIGR00794 1245469008858 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1245469008859 active site residue [active] 1245469008860 hypothetical protein; Provisional; Region: PRK08912 1245469008861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469008862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469008863 homodimer interface [polypeptide binding]; other site 1245469008864 catalytic residue [active] 1245469008865 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1245469008866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469008867 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1245469008868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469008869 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1245469008870 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1245469008871 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1245469008872 putative acyl-acceptor binding pocket; other site 1245469008873 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06501 1245469008874 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1245469008875 dimer interface [polypeptide binding]; other site 1245469008876 active site 1245469008877 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 1245469008878 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1245469008879 active site 1245469008880 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases [Lipid metabolism]; Region: FabA; COG0764 1245469008881 active site 2 [active] 1245469008882 active site 1 [active] 1245469008883 acyl carrier protein; Provisional; Region: PRK06508 1245469008884 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 1245469008885 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 1245469008886 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1245469008887 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1245469008888 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1245469008889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469008890 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469008891 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 1245469008892 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1245469008893 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1245469008894 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469008895 MarR family; Region: MarR_2; pfam12802 1245469008896 Domain of unknown function DUF87; Region: DUF87; pfam01935 1245469008897 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1245469008898 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1245469008899 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1245469008900 putative dimer interface [polypeptide binding]; other site 1245469008901 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1245469008902 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1245469008903 putative active site [active] 1245469008904 putative metal binding site [ion binding]; other site 1245469008905 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1245469008906 nudix motif; other site 1245469008907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469008908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469008909 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1245469008910 Sulfatase; Region: Sulfatase; pfam00884 1245469008911 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1245469008912 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469008913 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469008914 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469008915 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469008916 MarR family; Region: MarR; pfam01047 1245469008917 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1245469008918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469008919 N-terminal plug; other site 1245469008920 ligand-binding site [chemical binding]; other site 1245469008921 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1245469008922 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1245469008923 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1245469008924 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1245469008925 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1245469008926 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1245469008927 Peptidase family M50; Region: Peptidase_M50; pfam02163 1245469008928 active site 1245469008929 putative substrate binding region [chemical binding]; other site 1245469008930 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469008931 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1245469008932 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1245469008933 putative NAD(P) binding site [chemical binding]; other site 1245469008934 dimer interface [polypeptide binding]; other site 1245469008935 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469008936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469008937 dimerization interface [polypeptide binding]; other site 1245469008938 putative DNA binding site [nucleotide binding]; other site 1245469008939 putative Zn2+ binding site [ion binding]; other site 1245469008940 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1245469008941 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469008942 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469008943 protein binding site [polypeptide binding]; other site 1245469008944 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469008945 protein binding site [polypeptide binding]; other site 1245469008946 recombination factor protein RarA; Reviewed; Region: PRK13342 1245469008947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469008948 Walker A motif; other site 1245469008949 ATP binding site [chemical binding]; other site 1245469008950 Walker B motif; other site 1245469008951 arginine finger; other site 1245469008952 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1245469008953 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1245469008954 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469008955 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469008956 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1245469008957 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469008958 substrate binding pocket [chemical binding]; other site 1245469008959 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1245469008960 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469008961 RNA binding surface [nucleotide binding]; other site 1245469008962 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1245469008963 active site 1245469008964 ATP12 chaperone protein; Region: ATP12; cl02228 1245469008965 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1245469008966 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1245469008967 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1245469008968 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469008969 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469008970 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1245469008971 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1245469008972 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1245469008973 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1245469008974 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469008975 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469008976 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469008977 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469008978 dimerization interface [polypeptide binding]; other site 1245469008979 putative DNA binding site [nucleotide binding]; other site 1245469008980 putative Zn2+ binding site [ion binding]; other site 1245469008981 NIPSNAP; Region: NIPSNAP; pfam07978 1245469008982 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1245469008983 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1245469008984 tetramer interface [polypeptide binding]; other site 1245469008985 active site 1245469008986 Mg2+/Mn2+ binding site [ion binding]; other site 1245469008987 Predicted membrane protein [Function unknown]; Region: COG2860 1245469008988 UPF0126 domain; Region: UPF0126; pfam03458 1245469008989 UPF0126 domain; Region: UPF0126; pfam03458 1245469008990 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 1245469008991 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1245469008992 dimer interface [polypeptide binding]; other site 1245469008993 PYR/PP interface [polypeptide binding]; other site 1245469008994 TPP binding site [chemical binding]; other site 1245469008995 substrate binding site [chemical binding]; other site 1245469008996 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1245469008997 TPP-binding site [chemical binding]; other site 1245469008998 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1245469008999 PAS domain S-box; Region: sensory_box; TIGR00229 1245469009000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469009001 HWE histidine kinase; Region: HWE_HK; smart00911 1245469009002 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469009003 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469009004 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1245469009005 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1245469009006 active site 1245469009007 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1245469009008 DUF35 OB-fold domain; Region: DUF35; pfam01796 1245469009009 enoyl-CoA hydratase; Region: PLN02864 1245469009010 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1245469009011 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1245469009012 dimer interaction site [polypeptide binding]; other site 1245469009013 substrate-binding tunnel; other site 1245469009014 active site 1245469009015 catalytic site [active] 1245469009016 substrate binding site [chemical binding]; other site 1245469009017 short chain dehydrogenase; Provisional; Region: PRK07791 1245469009018 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1245469009019 homodimer interface [polypeptide binding]; other site 1245469009020 NAD binding site [chemical binding]; other site 1245469009021 active site 1245469009022 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469009023 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1245469009024 inhibitor site; inhibition site 1245469009025 active site 1245469009026 dimer interface [polypeptide binding]; other site 1245469009027 catalytic residue [active] 1245469009028 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469009029 HAMP domain; Region: HAMP; pfam00672 1245469009030 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 1245469009031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469009032 putative active site [active] 1245469009033 heme pocket [chemical binding]; other site 1245469009034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009035 ATP binding site [chemical binding]; other site 1245469009036 Mg2+ binding site [ion binding]; other site 1245469009037 G-X-G motif; other site 1245469009038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469009039 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1245469009040 active site 1245469009041 metal binding site [ion binding]; metal-binding site 1245469009042 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1245469009043 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1245469009044 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1245469009045 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469009046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469009047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009048 ATP binding site [chemical binding]; other site 1245469009049 Mg2+ binding site [ion binding]; other site 1245469009050 G-X-G motif; other site 1245469009051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469009052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009053 active site 1245469009054 phosphorylation site [posttranslational modification] 1245469009055 intermolecular recognition site; other site 1245469009056 dimerization interface [polypeptide binding]; other site 1245469009057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469009058 DNA binding site [nucleotide binding] 1245469009059 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1245469009060 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1245469009061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469009062 binding surface 1245469009063 TPR motif; other site 1245469009064 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1245469009065 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1245469009066 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1245469009067 catalytic residues [active] 1245469009068 central insert; other site 1245469009069 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1245469009070 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469009071 Sel1-like repeats; Region: SEL1; smart00671 1245469009072 Sel1-like repeats; Region: SEL1; smart00671 1245469009073 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1245469009074 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1245469009075 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1245469009076 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1245469009077 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1245469009078 4Fe-4S binding domain; Region: Fer4; pfam00037 1245469009079 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1245469009080 4Fe-4S binding domain; Region: Fer4; pfam00037 1245469009081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469009082 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009083 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009084 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009085 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009086 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009087 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009088 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1245469009089 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469009090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469009091 TPR motif; other site 1245469009092 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1245469009093 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1245469009094 substrate-cofactor binding pocket; other site 1245469009095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469009096 catalytic residue [active] 1245469009097 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1245469009098 DNA photolyase; Region: DNA_photolyase; pfam00875 1245469009099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469009100 dimerization interface [polypeptide binding]; other site 1245469009101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469009102 dimer interface [polypeptide binding]; other site 1245469009103 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469009104 putative CheW interface [polypeptide binding]; other site 1245469009105 DctM-like transporters; Region: DctM; pfam06808 1245469009106 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1245469009107 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1245469009108 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469009109 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469009110 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1245469009111 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1245469009112 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1245469009113 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1245469009114 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1245469009115 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1245469009116 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1245469009117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1245469009118 ATP binding site [chemical binding]; other site 1245469009119 putative Mg++ binding site [ion binding]; other site 1245469009120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469009121 nucleotide binding region [chemical binding]; other site 1245469009122 ATP-binding site [chemical binding]; other site 1245469009123 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1245469009124 RNA binding site [nucleotide binding]; other site 1245469009125 Predicted membrane protein (DUF2177); Region: DUF2177; pfam09945 1245469009126 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1245469009127 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1245469009128 dimer interface [polypeptide binding]; other site 1245469009129 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1245469009130 catalytic triad [active] 1245469009131 Sulfatase; Region: Sulfatase; cl17466 1245469009132 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1245469009133 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1245469009134 dimerization interface [polypeptide binding]; other site 1245469009135 metal binding site [ion binding]; metal-binding site 1245469009136 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469009137 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1245469009138 substrate binding pocket [chemical binding]; other site 1245469009139 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469009140 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469009141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469009142 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1245469009143 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1245469009144 transmembrane helices; other site 1245469009145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469009146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469009147 UDP-sulfoquinovose:DAG sulfoquinovosyltransferase; Region: PLN02871 1245469009148 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469009149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009150 active site 1245469009151 phosphorylation site [posttranslational modification] 1245469009152 intermolecular recognition site; other site 1245469009153 dimerization interface [polypeptide binding]; other site 1245469009154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469009155 Walker A motif; other site 1245469009156 ATP binding site [chemical binding]; other site 1245469009157 Walker B motif; other site 1245469009158 arginine finger; other site 1245469009159 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469009160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469009161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469009162 dimer interface [polypeptide binding]; other site 1245469009163 phosphorylation site [posttranslational modification] 1245469009164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009165 ATP binding site [chemical binding]; other site 1245469009166 Mg2+ binding site [ion binding]; other site 1245469009167 G-X-G motif; other site 1245469009168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469009169 PAS fold; Region: PAS_3; pfam08447 1245469009170 putative active site [active] 1245469009171 heme pocket [chemical binding]; other site 1245469009172 PAS domain S-box; Region: sensory_box; TIGR00229 1245469009173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469009174 putative active site [active] 1245469009175 heme pocket [chemical binding]; other site 1245469009176 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1245469009177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469009178 putative active site [active] 1245469009179 heme pocket [chemical binding]; other site 1245469009180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469009181 dimer interface [polypeptide binding]; other site 1245469009182 phosphorylation site [posttranslational modification] 1245469009183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009184 ATP binding site [chemical binding]; other site 1245469009185 Mg2+ binding site [ion binding]; other site 1245469009186 G-X-G motif; other site 1245469009187 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469009188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009189 active site 1245469009190 phosphorylation site [posttranslational modification] 1245469009191 intermolecular recognition site; other site 1245469009192 dimerization interface [polypeptide binding]; other site 1245469009193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1245469009194 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1245469009195 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1245469009196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469009197 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1245469009198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1245469009199 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1245469009200 carboxyltransferase (CT) interaction site; other site 1245469009201 biotinylation site [posttranslational modification]; other site 1245469009202 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1245469009203 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1245469009204 tetramer interface [polypeptide binding]; other site 1245469009205 active site 1245469009206 Mg2+/Mn2+ binding site [ion binding]; other site 1245469009207 Acylphosphatase; Region: Acylphosphatase; cl00551 1245469009208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469009209 S-adenosylmethionine binding site [chemical binding]; other site 1245469009210 Predicted transcriptional regulators [Transcription]; Region: COG1510 1245469009211 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469009212 putative DNA binding site [nucleotide binding]; other site 1245469009213 putative Zn2+ binding site [ion binding]; other site 1245469009214 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1245469009215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469009216 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1245469009217 NAD(P) binding site [chemical binding]; other site 1245469009218 active site 1245469009219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469009220 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469009221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469009222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469009223 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1245469009224 active site 1 [active] 1245469009225 dimer interface [polypeptide binding]; other site 1245469009226 hexamer interface [polypeptide binding]; other site 1245469009227 active site 2 [active] 1245469009228 lipoate-protein ligase B; Provisional; Region: PRK14341 1245469009229 hypothetical protein; Validated; Region: PRK06033 1245469009230 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469009231 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1245469009232 Trp docking motif [polypeptide binding]; other site 1245469009233 active site 1245469009234 quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871 1245469009235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469009236 substrate binding pocket [chemical binding]; other site 1245469009237 membrane-bound complex binding site; other site 1245469009238 hinge residues; other site 1245469009239 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469009240 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469009241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469009242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009243 active site 1245469009244 phosphorylation site [posttranslational modification] 1245469009245 intermolecular recognition site; other site 1245469009246 dimerization interface [polypeptide binding]; other site 1245469009247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469009248 DNA binding residues [nucleotide binding] 1245469009249 dimerization interface [polypeptide binding]; other site 1245469009250 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469009251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009252 active site 1245469009253 phosphorylation site [posttranslational modification] 1245469009254 intermolecular recognition site; other site 1245469009255 dimerization interface [polypeptide binding]; other site 1245469009256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469009257 DNA binding residues [nucleotide binding] 1245469009258 dimerization interface [polypeptide binding]; other site 1245469009259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469009260 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1245469009261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009262 ATP binding site [chemical binding]; other site 1245469009263 Mg2+ binding site [ion binding]; other site 1245469009264 G-X-G motif; other site 1245469009265 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469009266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009267 active site 1245469009268 phosphorylation site [posttranslational modification] 1245469009269 intermolecular recognition site; other site 1245469009270 dimerization interface [polypeptide binding]; other site 1245469009271 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1245469009272 FIST N domain; Region: FIST; pfam08495 1245469009273 FIST C domain; Region: FIST_C; pfam10442 1245469009274 Cytochrome c; Region: Cytochrom_C; cl11414 1245469009275 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1245469009276 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1245469009277 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1245469009278 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469009279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469009280 Walker A/P-loop; other site 1245469009281 ATP binding site [chemical binding]; other site 1245469009282 Q-loop/lid; other site 1245469009283 ABC transporter signature motif; other site 1245469009284 Walker B; other site 1245469009285 D-loop; other site 1245469009286 H-loop/switch region; other site 1245469009287 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469009288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469009289 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469009290 RTX toxin acyltransferase family; Region: HlyC; cl01131 1245469009291 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009292 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469009293 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009294 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009295 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009296 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009297 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009298 legume lectins; Region: lectin_L-type; cd01951 1245469009299 homotetramer interaction site [polypeptide binding]; other site 1245469009300 carbohydrate binding site [chemical binding]; other site 1245469009301 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009302 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009303 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009304 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1245469009305 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469009306 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009307 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009308 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009309 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469009310 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009311 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009312 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469009313 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009314 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009315 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469009316 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009317 Ca2+ binding site [ion binding]; other site 1245469009318 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009319 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009320 Putative Ig domain; Region: He_PIG; pfam05345 1245469009321 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009322 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009323 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469009324 Ca2+ binding site [ion binding]; other site 1245469009325 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009326 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469009327 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009328 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469009329 Ca2+ binding site [ion binding]; other site 1245469009330 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009331 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009332 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469009333 Ca2+ binding site [ion binding]; other site 1245469009334 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469009335 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469009336 Ca2+ binding site [ion binding]; other site 1245469009337 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009338 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009339 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009340 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009341 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009342 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009343 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009344 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 1245469009345 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469009346 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469009347 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469009348 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1245469009349 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469009350 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1245469009351 Cache domain; Region: Cache_1; pfam02743 1245469009352 PAS fold; Region: PAS_4; pfam08448 1245469009353 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469009354 putative active site [active] 1245469009355 heme pocket [chemical binding]; other site 1245469009356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009357 ATP binding site [chemical binding]; other site 1245469009358 G-X-G motif; other site 1245469009359 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469009360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009361 active site 1245469009362 phosphorylation site [posttranslational modification] 1245469009363 intermolecular recognition site; other site 1245469009364 dimerization interface [polypeptide binding]; other site 1245469009365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469009366 non-specific DNA binding site [nucleotide binding]; other site 1245469009367 salt bridge; other site 1245469009368 sequence-specific DNA binding site [nucleotide binding]; other site 1245469009369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469009370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469009371 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469009372 dimerization interface [polypeptide binding]; other site 1245469009373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469009374 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469009375 NAD(P) binding site [chemical binding]; other site 1245469009376 active site 1245469009377 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1245469009378 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1245469009379 active site 1245469009380 catalytic site [active] 1245469009381 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469009382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469009383 non-specific DNA binding site [nucleotide binding]; other site 1245469009384 salt bridge; other site 1245469009385 sequence-specific DNA binding site [nucleotide binding]; other site 1245469009386 Cupin domain; Region: Cupin_2; pfam07883 1245469009387 amidase; Provisional; Region: PRK07486 1245469009388 Amidase; Region: Amidase; cl11426 1245469009389 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1245469009390 homotrimer interaction site [polypeptide binding]; other site 1245469009391 putative active site [active] 1245469009392 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469009393 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469009394 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1245469009395 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1245469009396 NodB motif; other site 1245469009397 active site 1245469009398 catalytic site [active] 1245469009399 metal binding site [ion binding]; metal-binding site 1245469009400 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1245469009401 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1245469009402 NodB motif; other site 1245469009403 active site 1245469009404 catalytic site [active] 1245469009405 metal binding site [ion binding]; metal-binding site 1245469009406 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1245469009407 MgtE intracellular N domain; Region: MgtE_N; smart00924 1245469009408 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1245469009409 Divalent cation transporter; Region: MgtE; cl00786 1245469009410 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469009411 non-specific DNA binding site [nucleotide binding]; other site 1245469009412 salt bridge; other site 1245469009413 sequence-specific DNA binding site [nucleotide binding]; other site 1245469009414 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469009415 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469009416 active site 1245469009417 catalytic tetrad [active] 1245469009418 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1245469009419 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469009420 putative C-terminal domain interface [polypeptide binding]; other site 1245469009421 putative GSH binding site (G-site) [chemical binding]; other site 1245469009422 putative dimer interface [polypeptide binding]; other site 1245469009423 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1245469009424 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469009425 putative N-terminal domain interface [polypeptide binding]; other site 1245469009426 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1245469009427 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 1245469009428 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1245469009429 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1245469009430 active site 1245469009431 ATP-binding site [chemical binding]; other site 1245469009432 pantoate-binding site; other site 1245469009433 HXXH motif; other site 1245469009434 ATPase MipZ; Region: MipZ; pfam09140 1245469009435 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469009436 P-loop; other site 1245469009437 Magnesium ion binding site [ion binding]; other site 1245469009438 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1245469009439 Magnesium ion binding site [ion binding]; other site 1245469009440 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469009441 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1245469009442 nucleophilic elbow; other site 1245469009443 catalytic triad; other site 1245469009444 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1245469009445 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1245469009446 HSP70 interaction site [polypeptide binding]; other site 1245469009447 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1245469009448 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1245469009449 Sporulation related domain; Region: SPOR; pfam05036 1245469009450 Phasin protein; Region: Phasin_2; pfam09361 1245469009451 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1245469009452 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1245469009453 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1245469009454 metal ion-dependent adhesion site (MIDAS); other site 1245469009455 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1245469009456 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1245469009457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469009458 Walker A motif; other site 1245469009459 ATP binding site [chemical binding]; other site 1245469009460 Walker B motif; other site 1245469009461 arginine finger; other site 1245469009462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469009463 Walker A motif; other site 1245469009464 ATP binding site [chemical binding]; other site 1245469009465 Walker B motif; other site 1245469009466 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1245469009467 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469009468 hypothetical protein; Provisional; Region: PRK10621 1245469009469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469009470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1245469009471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469009472 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469009473 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469009474 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1245469009475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469009476 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 1245469009477 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469009478 putative active site [active] 1245469009479 catalytic triad [active] 1245469009480 putative dimer interface [polypeptide binding]; other site 1245469009481 PEGA domain; Region: PEGA; pfam08308 1245469009482 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 1245469009483 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1245469009484 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469009485 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469009486 catalytic residue [active] 1245469009487 Sporulation related domain; Region: SPOR; pfam05036 1245469009488 AzlC protein; Region: AzlC; pfam03591 1245469009489 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1245469009490 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1245469009491 homodimer interaction site [polypeptide binding]; other site 1245469009492 cofactor binding site; other site 1245469009493 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1245469009494 quinolinate synthetase; Provisional; Region: PRK09375 1245469009495 L-aspartate oxidase; Provisional; Region: PRK07512 1245469009496 L-aspartate oxidase; Provisional; Region: PRK06175 1245469009497 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1245469009498 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06106 1245469009499 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1245469009500 dimerization interface [polypeptide binding]; other site 1245469009501 active site 1245469009502 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1245469009503 HIT family signature motif; other site 1245469009504 catalytic residue [active] 1245469009505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 1245469009506 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1245469009507 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1245469009508 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1245469009509 active site 1245469009510 catalytic site [active] 1245469009511 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1245469009512 homotrimer interaction site [polypeptide binding]; other site 1245469009513 putative active site [active] 1245469009514 Domain of unknown function (DUF1849); Region: DUF1849; pfam08904 1245469009515 DNA polymerase IV; Provisional; Region: PRK02794 1245469009516 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1245469009517 active site 1245469009518 DNA binding site [nucleotide binding] 1245469009519 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 1245469009520 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469009521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009522 active site 1245469009523 phosphorylation site [posttranslational modification] 1245469009524 intermolecular recognition site; other site 1245469009525 dimerization interface [polypeptide binding]; other site 1245469009526 response regulator PleD; Reviewed; Region: pleD; PRK09581 1245469009527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009528 active site 1245469009529 phosphorylation site [posttranslational modification] 1245469009530 intermolecular recognition site; other site 1245469009531 dimerization interface [polypeptide binding]; other site 1245469009532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009533 active site 1245469009534 phosphorylation site [posttranslational modification] 1245469009535 intermolecular recognition site; other site 1245469009536 dimerization interface [polypeptide binding]; other site 1245469009537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469009538 metal binding site [ion binding]; metal-binding site 1245469009539 active site 1245469009540 I-site; other site 1245469009541 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1245469009542 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469009543 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1245469009544 catalytic triad [active] 1245469009545 conserved cis-peptide bond; other site 1245469009546 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 1245469009547 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 1245469009548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469009549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469009550 dimer interface [polypeptide binding]; other site 1245469009551 phosphorylation site [posttranslational modification] 1245469009552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469009553 ATP binding site [chemical binding]; other site 1245469009554 Mg2+ binding site [ion binding]; other site 1245469009555 G-X-G motif; other site 1245469009556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469009557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469009558 active site 1245469009559 phosphorylation site [posttranslational modification] 1245469009560 intermolecular recognition site; other site 1245469009561 dimerization interface [polypeptide binding]; other site 1245469009562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469009563 DNA binding site [nucleotide binding] 1245469009564 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1245469009565 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1245469009566 heme-binding site [chemical binding]; other site 1245469009567 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469009568 dimer interface [polypeptide binding]; other site 1245469009569 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469009570 putative CheW interface [polypeptide binding]; other site 1245469009571 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1245469009572 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1245469009573 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1245469009574 active site 1245469009575 non-prolyl cis peptide bond; other site 1245469009576 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469009577 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1245469009578 metal binding site [ion binding]; metal-binding site 1245469009579 putative dimer interface [polypeptide binding]; other site 1245469009580 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1245469009581 homotrimer interaction site [polypeptide binding]; other site 1245469009582 putative active site [active] 1245469009583 NUDIX domain; Region: NUDIX; pfam00293 1245469009584 hypothetical protein; Provisional; Region: PRK05978 1245469009585 ribonuclease R; Region: RNase_R; TIGR02063 1245469009586 RNB domain; Region: RNB; pfam00773 1245469009587 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1245469009588 RNA binding site [nucleotide binding]; other site 1245469009589 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1245469009590 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1245469009591 active site 1245469009592 interdomain interaction site; other site 1245469009593 putative metal-binding site [ion binding]; other site 1245469009594 nucleotide binding site [chemical binding]; other site 1245469009595 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1245469009596 domain I; other site 1245469009597 DNA binding groove [nucleotide binding] 1245469009598 phosphate binding site [ion binding]; other site 1245469009599 domain II; other site 1245469009600 domain III; other site 1245469009601 nucleotide binding site [chemical binding]; other site 1245469009602 catalytic site [active] 1245469009603 domain IV; other site 1245469009604 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1245469009605 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1245469009606 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1245469009607 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1245469009608 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469009609 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1245469009610 short chain dehydrogenase; Provisional; Region: PRK06500 1245469009611 classical (c) SDRs; Region: SDR_c; cd05233 1245469009612 NAD(P) binding site [chemical binding]; other site 1245469009613 active site 1245469009614 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 1245469009615 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1245469009616 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469009617 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1245469009618 DNA protecting protein DprA; Region: dprA; TIGR00732 1245469009619 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1245469009620 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1245469009621 active site 1245469009622 nucleophile elbow; other site 1245469009623 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1245469009624 dihydroorotase; Validated; Region: PRK09059 1245469009625 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469009626 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1245469009627 active site 1245469009628 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1245469009629 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1245469009630 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1245469009631 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1245469009632 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469009633 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469009634 active site 1245469009635 CAAX protease self-immunity; Region: Abi; pfam02517 1245469009636 Predicted permeases [General function prediction only]; Region: COG0679 1245469009637 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1245469009638 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1245469009639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469009640 Walker A/P-loop; other site 1245469009641 ATP binding site [chemical binding]; other site 1245469009642 Q-loop/lid; other site 1245469009643 ABC transporter signature motif; other site 1245469009644 Walker B; other site 1245469009645 D-loop; other site 1245469009646 H-loop/switch region; other site 1245469009647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469009648 Putative cyclase; Region: Cyclase; pfam04199 1245469009649 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469009650 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469009651 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1245469009652 putative dimerization interface [polypeptide binding]; other site 1245469009653 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1245469009654 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1245469009655 FMN binding site [chemical binding]; other site 1245469009656 substrate binding site [chemical binding]; other site 1245469009657 putative catalytic residue [active] 1245469009658 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1245469009659 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1245469009660 FMN binding site [chemical binding]; other site 1245469009661 substrate binding site [chemical binding]; other site 1245469009662 putative catalytic residue [active] 1245469009663 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1245469009664 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469009665 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1245469009666 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1245469009667 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1245469009668 GatB domain; Region: GatB_Yqey; smart00845 1245469009669 Sel1 repeat; Region: Sel1; cl02723 1245469009670 reverse gyrase; Reviewed; Region: PRK09401 1245469009671 Porin subfamily; Region: Porin_2; pfam02530 1245469009672 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 1245469009673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469009674 MarR family; Region: MarR; pfam01047 1245469009675 Porin subfamily; Region: Porin_2; pfam02530 1245469009676 Porin subfamily; Region: Porin_2; pfam02530 1245469009677 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1245469009678 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469009679 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469009680 catalytic residue [active] 1245469009681 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469009682 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1245469009683 dimer interface [polypeptide binding]; other site 1245469009684 active site 1245469009685 catalytic residue [active] 1245469009686 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1245469009687 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1245469009688 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1245469009689 SmpB-tmRNA interface; other site 1245469009690 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1245469009691 catalytic triad [active] 1245469009692 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1245469009693 Fe-S cluster binding site [ion binding]; other site 1245469009694 DNA binding site [nucleotide binding] 1245469009695 active site 1245469009696 LabA_like proteins; Region: LabA; cd10911 1245469009697 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1245469009698 putative metal binding site [ion binding]; other site 1245469009699 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1245469009700 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1245469009701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469009702 Zn2+ binding site [ion binding]; other site 1245469009703 Mg2+ binding site [ion binding]; other site 1245469009704 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1245469009705 synthetase active site [active] 1245469009706 NTP binding site [chemical binding]; other site 1245469009707 metal binding site [ion binding]; metal-binding site 1245469009708 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1245469009709 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1245469009710 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1245469009711 active site 1245469009712 hydrophilic channel; other site 1245469009713 dimerization interface [polypeptide binding]; other site 1245469009714 catalytic residues [active] 1245469009715 active site lid [active] 1245469009716 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1245469009717 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1245469009718 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1245469009719 Catalytic site [active] 1245469009720 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1245469009721 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1245469009722 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1245469009723 dimerization interface [polypeptide binding]; other site 1245469009724 active site 1245469009725 metal binding site [ion binding]; metal-binding site 1245469009726 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1245469009727 dsRNA binding site [nucleotide binding]; other site 1245469009728 GTPase Era; Reviewed; Region: era; PRK00089 1245469009729 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1245469009730 G1 box; other site 1245469009731 GTP/Mg2+ binding site [chemical binding]; other site 1245469009732 Switch I region; other site 1245469009733 G2 box; other site 1245469009734 Switch II region; other site 1245469009735 G3 box; other site 1245469009736 G4 box; other site 1245469009737 G5 box; other site 1245469009738 KH domain; Region: KH_2; pfam07650 1245469009739 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1245469009740 Recombination protein O N terminal; Region: RecO_N; pfam11967 1245469009741 Recombination protein O C terminal; Region: RecO_C; pfam02565 1245469009742 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1245469009743 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1245469009744 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1245469009745 putative dimer interface [polypeptide binding]; other site 1245469009746 N-terminal domain interface [polypeptide binding]; other site 1245469009747 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469009748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 1245469009749 ACT domain; Region: ACT_3; pfam10000 1245469009750 Family description; Region: ACT_7; pfam13840 1245469009751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469009752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469009753 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1245469009754 dimerization interface [polypeptide binding]; other site 1245469009755 hypothetical protein; Validated; Region: PRK07586 1245469009756 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469009757 PYR/PP interface [polypeptide binding]; other site 1245469009758 dimer interface [polypeptide binding]; other site 1245469009759 TPP binding site [chemical binding]; other site 1245469009760 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1245469009761 TPP-binding site [chemical binding]; other site 1245469009762 dimer interface [polypeptide binding]; other site 1245469009763 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1245469009764 glutathione S-transferase; Region: PLN02395 1245469009765 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469009766 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469009767 N-terminal domain interface [polypeptide binding]; other site 1245469009768 dimer interface [polypeptide binding]; other site 1245469009769 substrate binding pocket (H-site) [chemical binding]; other site 1245469009770 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1245469009771 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469009772 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469009773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1245469009774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469009775 NAD(P) binding site [chemical binding]; other site 1245469009776 active site 1245469009777 putative succinate dehydrogenase; Reviewed; Region: PRK12842 1245469009778 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1245469009779 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469009780 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469009781 putative ligand binding site [chemical binding]; other site 1245469009782 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469009783 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469009784 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1245469009785 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1245469009786 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1245469009787 CAP-like domain; other site 1245469009788 active site 1245469009789 primary dimer interface [polypeptide binding]; other site 1245469009790 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1245469009791 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1245469009792 Chromate transporter; Region: Chromate_transp; pfam02417 1245469009793 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1245469009794 active site residue [active] 1245469009795 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 1245469009796 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1245469009797 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1245469009798 ArsC family; Region: ArsC; pfam03960 1245469009799 catalytic residues [active] 1245469009800 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469009801 cyclase homology domain; Region: CHD; cd07302 1245469009802 nucleotidyl binding site; other site 1245469009803 metal binding site [ion binding]; metal-binding site 1245469009804 dimer interface [polypeptide binding]; other site 1245469009805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1245469009806 Ligand Binding Site [chemical binding]; other site 1245469009807 H+ Antiporter protein; Region: 2A0121; TIGR00900 1245469009808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469009809 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469009810 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1245469009811 manganese transport protein MntH; Reviewed; Region: PRK00701 1245469009812 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1245469009813 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1245469009814 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1245469009815 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1245469009816 RDD family; Region: RDD; pfam06271 1245469009817 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 1245469009818 dimer interface [polypeptide binding]; other site 1245469009819 allosteric magnesium binding site [ion binding]; other site 1245469009820 active site 1245469009821 aspartate-rich active site metal binding site; other site 1245469009822 Schiff base residues; other site 1245469009823 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469009824 MarR family; Region: MarR_2; cl17246 1245469009825 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1245469009826 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1245469009827 dimer interface [polypeptide binding]; other site 1245469009828 active site 1245469009829 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1245469009830 folate binding site [chemical binding]; other site 1245469009831 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1245469009832 ATP cone domain; Region: ATP-cone; pfam03477 1245469009833 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1245469009834 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1245469009835 catalytic motif [active] 1245469009836 Zn binding site [ion binding]; other site 1245469009837 RibD C-terminal domain; Region: RibD_C; cl17279 1245469009838 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1245469009839 Lumazine binding domain; Region: Lum_binding; pfam00677 1245469009840 Lumazine binding domain; Region: Lum_binding; pfam00677 1245469009841 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1245469009842 homopentamer interface [polypeptide binding]; other site 1245469009843 active site 1245469009844 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1245469009845 putative RNA binding site [nucleotide binding]; other site 1245469009846 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1245469009847 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1245469009848 ATP binding site [chemical binding]; other site 1245469009849 dimerization interface [polypeptide binding]; other site 1245469009850 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1245469009851 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1245469009852 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469009853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469009854 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 1245469009855 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1245469009856 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981 1245469009857 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1245469009858 putative phosphate acyltransferase; Provisional; Region: PRK05331 1245469009859 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1245469009860 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1245469009861 dimer interface [polypeptide binding]; other site 1245469009862 active site 1245469009863 CoA binding pocket [chemical binding]; other site 1245469009864 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1245469009865 IHF dimer interface [polypeptide binding]; other site 1245469009866 IHF - DNA interface [nucleotide binding]; other site 1245469009867 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1245469009868 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1245469009869 DNA binding residues [nucleotide binding] 1245469009870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1245469009871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469009872 S-adenosylmethionine binding site [chemical binding]; other site 1245469009873 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1245469009874 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1245469009875 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1245469009876 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469009877 Walker A/P-loop; other site 1245469009878 ATP binding site [chemical binding]; other site 1245469009879 Q-loop/lid; other site 1245469009880 ABC transporter signature motif; other site 1245469009881 Walker B; other site 1245469009882 D-loop; other site 1245469009883 H-loop/switch region; other site 1245469009884 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469009885 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469009886 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1245469009887 catalytic triad [active] 1245469009888 conserved cis-peptide bond; other site 1245469009889 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469009890 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1245469009891 TM-ABC transporter signature motif; other site 1245469009892 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469009893 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1245469009894 TM-ABC transporter signature motif; other site 1245469009895 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1245469009896 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1245469009897 putative ligand binding site [chemical binding]; other site 1245469009898 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469009899 classical (c) SDRs; Region: SDR_c; cd05233 1245469009900 NAD(P) binding site [chemical binding]; other site 1245469009901 active site 1245469009902 GcrA cell cycle regulator; Region: GcrA; cl11564 1245469009903 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1245469009904 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1245469009905 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1245469009906 putative active site [active] 1245469009907 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1245469009908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469009909 binding surface 1245469009910 TPR motif; other site 1245469009911 TPR repeat; Region: TPR_11; pfam13414 1245469009912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469009913 binding surface 1245469009914 TPR repeat; Region: TPR_11; pfam13414 1245469009915 TPR motif; other site 1245469009916 TPR repeat; Region: TPR_11; pfam13414 1245469009917 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469009918 binding surface 1245469009919 TPR motif; other site 1245469009920 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469009921 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 1245469009922 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1245469009923 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1245469009924 NAD(P) binding pocket [chemical binding]; other site 1245469009925 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1245469009926 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1245469009927 NAD(P) binding pocket [chemical binding]; other site 1245469009928 O-Antigen ligase; Region: Wzy_C; cl04850 1245469009929 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1245469009930 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1245469009931 prephenate dehydrogenase; Validated; Region: PRK08507 1245469009932 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1245469009933 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1245469009934 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469009935 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1245469009936 AAA domain; Region: AAA_31; pfam13614 1245469009937 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1245469009938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1245469009939 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1245469009940 Putative catalytic NodB homology domain of Mesorhizobium loti Mlr8448 protein and its bacterial homologs; Region: CE4_Mlr8448_like_5s; cd10968 1245469009941 putative active site [active] 1245469009942 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 1245469009943 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1245469009944 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1245469009945 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 1245469009946 flagellin; Provisional; Region: PRK14708 1245469009947 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994 1245469009948 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1245469009949 homodimer interface [polypeptide binding]; other site 1245469009950 substrate-cofactor binding pocket; other site 1245469009951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469009952 catalytic residue [active] 1245469009953 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1245469009954 enoyl-CoA hydratase; Validated; Region: PRK08139 1245469009955 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469009956 substrate binding site [chemical binding]; other site 1245469009957 oxyanion hole (OAH) forming residues; other site 1245469009958 trimer interface [polypeptide binding]; other site 1245469009959 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469009960 CoenzymeA binding site [chemical binding]; other site 1245469009961 subunit interaction site [polypeptide binding]; other site 1245469009962 PHB binding site; other site 1245469009963 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1245469009964 23S rRNA interface [nucleotide binding]; other site 1245469009965 L3 interface [polypeptide binding]; other site 1245469009966 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1245469009967 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1245469009968 putative active site [active] 1245469009969 putative metal binding site [ion binding]; other site 1245469009970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469009971 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1245469009972 YhhN-like protein; Region: YhhN; cl01505 1245469009973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469009974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469009975 metal binding site [ion binding]; metal-binding site 1245469009976 active site 1245469009977 I-site; other site 1245469009978 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1245469009979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1245469009980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469009981 metabolite-proton symporter; Region: 2A0106; TIGR00883 1245469009982 putative substrate translocation pore; other site 1245469009983 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469009984 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1245469009985 metal binding site [ion binding]; metal-binding site 1245469009986 putative dimer interface [polypeptide binding]; other site 1245469009987 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1245469009988 Peptidase C26; Region: Peptidase_C26; pfam07722 1245469009989 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1245469009990 catalytic triad [active] 1245469009991 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 1245469009992 glutamine synthetase; Provisional; Region: glnA; PRK09469 1245469009993 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1245469009994 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1245469009995 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1245469009996 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1245469009997 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1245469009998 putative carbohydrate kinase; Provisional; Region: PRK10565 1245469009999 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1245469010000 putative substrate binding site [chemical binding]; other site 1245469010001 putative ATP binding site [chemical binding]; other site 1245469010002 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1245469010003 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1245469010004 metal binding site [ion binding]; metal-binding site 1245469010005 substrate binding pocket [chemical binding]; other site 1245469010006 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1245469010007 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1245469010008 trigger factor; Provisional; Region: tig; PRK01490 1245469010009 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1245469010010 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1245469010011 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1245469010012 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1245469010013 oligomer interface [polypeptide binding]; other site 1245469010014 active site residues [active] 1245469010015 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1245469010016 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1245469010017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469010018 Walker A motif; other site 1245469010019 ATP binding site [chemical binding]; other site 1245469010020 Walker B motif; other site 1245469010021 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1245469010022 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1245469010023 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1245469010024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469010025 Walker A motif; other site 1245469010026 ATP binding site [chemical binding]; other site 1245469010027 Walker B motif; other site 1245469010028 arginine finger; other site 1245469010029 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1245469010030 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469010031 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469010032 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469010033 ligand binding site [chemical binding]; other site 1245469010034 flexible hinge region; other site 1245469010035 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469010036 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1245469010037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469010038 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1245469010039 peptidase T; Region: peptidase-T; TIGR01882 1245469010040 metal binding site [ion binding]; metal-binding site 1245469010041 dimer interface [polypeptide binding]; other site 1245469010042 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1245469010043 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1245469010044 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 1245469010045 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1245469010046 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1245469010047 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1245469010048 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1245469010049 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1245469010050 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1245469010051 putative dimer interface [polypeptide binding]; other site 1245469010052 [2Fe-2S] cluster binding site [ion binding]; other site 1245469010053 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 1245469010054 SLBB domain; Region: SLBB; pfam10531 1245469010055 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1245469010056 NADH dehydrogenase subunit G; Validated; Region: PRK09130 1245469010057 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469010058 catalytic loop [active] 1245469010059 iron binding site [ion binding]; other site 1245469010060 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1245469010061 MopB_Res_Cmplx1_Nad11: The second domain of the Nad11/75-kDa subunit of the NADH-quinone oxidoreductase/respiratory complex I/NADH dehydrogenase-1(NDH-1) of eukaryotes and the Nqo3/G subunit of alphaproteobacteria NDH-1. The NADH-quinone oxidoreductase...; Region: MopB_Res-Cmplx1_Nad11; cd02773 1245469010062 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 1245469010063 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1245469010064 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1245469010065 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1245469010066 4Fe-4S binding domain; Region: Fer4; pfam00037 1245469010067 4Fe-4S binding domain; Region: Fer4; pfam00037 1245469010068 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1245469010069 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1245469010070 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1245469010071 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1245469010072 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1245469010073 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1245469010074 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1245469010075 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1245469010076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1245469010077 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1245469010078 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00196 1245469010079 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1245469010080 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1245469010081 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1245469010082 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1245469010083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469010084 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1245469010085 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469010086 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1245469010087 dimer interface [polypeptide binding]; other site 1245469010088 substrate binding site [chemical binding]; other site 1245469010089 metal binding site [ion binding]; metal-binding site 1245469010090 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 1245469010091 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1245469010092 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469010093 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469010094 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469010095 TM-ABC transporter signature motif; other site 1245469010096 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469010097 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469010098 Walker A/P-loop; other site 1245469010099 ATP binding site [chemical binding]; other site 1245469010100 Q-loop/lid; other site 1245469010101 ABC transporter signature motif; other site 1245469010102 Walker B; other site 1245469010103 D-loop; other site 1245469010104 H-loop/switch region; other site 1245469010105 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469010106 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1245469010107 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_5; cd06313 1245469010108 putative ligand binding site [chemical binding]; other site 1245469010109 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469010110 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469010111 active site 1245469010112 metal binding site [ion binding]; metal-binding site 1245469010113 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1245469010114 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1245469010115 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469010116 N-terminal plug; other site 1245469010117 ligand-binding site [chemical binding]; other site 1245469010118 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1245469010119 Asp-box motif; other site 1245469010120 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1245469010121 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1245469010122 catalytic residues [active] 1245469010123 prolyl-tRNA synthetase; Provisional; Region: PRK12325 1245469010124 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1245469010125 dimer interface [polypeptide binding]; other site 1245469010126 motif 1; other site 1245469010127 active site 1245469010128 motif 2; other site 1245469010129 motif 3; other site 1245469010130 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1245469010131 anticodon binding site; other site 1245469010132 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1245469010133 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1245469010134 FtsX-like permease family; Region: FtsX; pfam02687 1245469010135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469010136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469010137 Walker A/P-loop; other site 1245469010138 ATP binding site [chemical binding]; other site 1245469010139 Q-loop/lid; other site 1245469010140 ABC transporter signature motif; other site 1245469010141 Walker B; other site 1245469010142 D-loop; other site 1245469010143 H-loop/switch region; other site 1245469010144 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469010145 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469010146 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469010147 NAD(P) binding site [chemical binding]; other site 1245469010148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469010149 sequence-specific DNA binding site [nucleotide binding]; other site 1245469010150 salt bridge; other site 1245469010151 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469010152 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 1245469010153 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469010154 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1245469010155 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1245469010156 putative active site [active] 1245469010157 putative PHP Thumb interface [polypeptide binding]; other site 1245469010158 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1245469010159 generic binding surface I; other site 1245469010160 generic binding surface II; other site 1245469010161 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 1245469010162 Caspase domain; Region: Peptidase_C14; pfam00656 1245469010163 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1245469010164 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469010165 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1245469010166 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1245469010167 phosphopeptide binding site; other site 1245469010168 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1245469010169 30S ribosomal protein S2/unknown domain fusion protein; Provisional; Region: rpsB; PRK12311 1245469010170 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1245469010171 rRNA interaction site [nucleotide binding]; other site 1245469010172 S8 interaction site; other site 1245469010173 putative laminin-1 binding site; other site 1245469010174 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1245469010175 elongation factor Ts; Provisional; Region: tsf; PRK09377 1245469010176 UBA/TS-N domain; Region: UBA; pfam00627 1245469010177 Elongation factor TS; Region: EF_TS; pfam00889 1245469010178 Elongation factor TS; Region: EF_TS; pfam00889 1245469010179 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1245469010180 putative nucleotide binding site [chemical binding]; other site 1245469010181 uridine monophosphate binding site [chemical binding]; other site 1245469010182 homohexameric interface [polypeptide binding]; other site 1245469010183 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1245469010184 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1245469010185 hinge region; other site 1245469010186 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834 1245469010187 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1245469010188 catalytic residue [active] 1245469010189 putative FPP diphosphate binding site; other site 1245469010190 putative FPP binding hydrophobic cleft; other site 1245469010191 dimer interface [polypeptide binding]; other site 1245469010192 putative IPP diphosphate binding site; other site 1245469010193 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1245469010194 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1245469010195 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1245469010196 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1245469010197 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1245469010198 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1245469010199 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1245469010200 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1245469010201 active site 1245469010202 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1245469010203 protein binding site [polypeptide binding]; other site 1245469010204 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1245469010205 putative substrate binding region [chemical binding]; other site 1245469010206 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1245469010207 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469010208 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469010209 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469010210 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469010211 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1245469010212 Surface antigen; Region: Bac_surface_Ag; pfam01103 1245469010213 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1245469010214 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1245469010215 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1245469010216 trimer interface [polypeptide binding]; other site 1245469010217 active site 1245469010218 UDP-GlcNAc binding site [chemical binding]; other site 1245469010219 lipid binding site [chemical binding]; lipid-binding site 1245469010220 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1245469010221 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1245469010222 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1245469010223 active site 1245469010224 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1245469010225 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 1245469010226 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1245469010227 Dienelactone hydrolase family; Region: DLH; pfam01738 1245469010228 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469010229 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1245469010230 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1245469010231 dimer interface [polypeptide binding]; other site 1245469010232 active site 1245469010233 citrylCoA binding site [chemical binding]; other site 1245469010234 NADH binding [chemical binding]; other site 1245469010235 cationic pore residues; other site 1245469010236 oxalacetate/citrate binding site [chemical binding]; other site 1245469010237 coenzyme A binding site [chemical binding]; other site 1245469010238 catalytic triad [active] 1245469010239 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1245469010240 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469010241 active site 1245469010242 HIGH motif; other site 1245469010243 nucleotide binding site [chemical binding]; other site 1245469010244 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1245469010245 active site 1245469010246 KMSKS motif; other site 1245469010247 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1245469010248 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469010249 active site 1245469010250 HIGH motif; other site 1245469010251 nucleotide binding site [chemical binding]; other site 1245469010252 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1245469010253 KMSKS motif; other site 1245469010254 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1245469010255 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1245469010256 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1245469010257 Competence protein; Region: Competence; pfam03772 1245469010258 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1245469010259 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1245469010260 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1245469010261 Protein of unknown function (DUF736); Region: DUF736; pfam05284 1245469010262 TrwC relaxase; Region: TrwC; pfam08751 1245469010263 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1245469010264 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469010265 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1245469010266 Walker A motif; other site 1245469010267 ATP binding site [chemical binding]; other site 1245469010268 Walker B motif; other site 1245469010269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1245469010270 sequence-specific DNA binding site [nucleotide binding]; other site 1245469010271 salt bridge; other site 1245469010272 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1245469010273 Part of AAA domain; Region: AAA_19; pfam13245 1245469010274 Family description; Region: UvrD_C_2; pfam13538 1245469010275 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1245469010276 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469010277 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1245469010278 putative active site [active] 1245469010279 putative metal binding site [ion binding]; other site 1245469010280 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469010281 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1245469010282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469010283 putative DNA binding site [nucleotide binding]; other site 1245469010284 dimerization interface [polypeptide binding]; other site 1245469010285 putative Zn2+ binding site [ion binding]; other site 1245469010286 Domain of unknown function (DUF955); Region: DUF955; cl01076 1245469010287 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1245469010288 active site 1245469010289 catalytic residues [active] 1245469010290 DNA binding site [nucleotide binding] 1245469010291 Int/Topo IB signature motif; other site 1245469010292 Competence protein; Region: Competence; pfam03772 1245469010293 LexA repressor; Validated; Region: PRK00215 1245469010294 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1245469010295 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1245469010296 Catalytic site [active] 1245469010297 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1245469010298 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1245469010299 dimer interface [polypeptide binding]; other site 1245469010300 putative functional site; other site 1245469010301 putative MPT binding site; other site 1245469010302 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1245469010303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469010304 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1245469010305 putative substrate binding pocket [chemical binding]; other site 1245469010306 putative dimerization interface [polypeptide binding]; other site 1245469010307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469010308 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469010309 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1245469010310 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1245469010311 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1245469010312 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1245469010313 putative catalytic residue [active] 1245469010314 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1245469010315 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1245469010316 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1245469010317 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1245469010318 active site 1245469010319 substrate binding site [chemical binding]; other site 1245469010320 FMN binding site [chemical binding]; other site 1245469010321 putative catalytic residues [active] 1245469010322 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1245469010323 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1245469010324 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1245469010325 protein binding site [polypeptide binding]; other site 1245469010326 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1245469010327 Catalytic dyad [active] 1245469010328 PAS fold; Region: PAS_7; pfam12860 1245469010329 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469010330 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469010331 metal binding site [ion binding]; metal-binding site 1245469010332 active site 1245469010333 I-site; other site 1245469010334 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469010335 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1245469010336 trimer interface [polypeptide binding]; other site 1245469010337 dimer interface [polypeptide binding]; other site 1245469010338 putative active site [active] 1245469010339 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1245469010340 active site 1245469010341 ribulose/triose binding site [chemical binding]; other site 1245469010342 phosphate binding site [ion binding]; other site 1245469010343 substrate (anthranilate) binding pocket [chemical binding]; other site 1245469010344 product (indole) binding pocket [chemical binding]; other site 1245469010345 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1245469010346 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1245469010347 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1245469010348 SurA N-terminal domain; Region: SurA_N_3; cl07813 1245469010349 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1245469010350 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1245469010351 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1245469010352 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1245469010353 triosephosphate isomerase; Provisional; Region: PRK14565 1245469010354 substrate binding site [chemical binding]; other site 1245469010355 dimer interface [polypeptide binding]; other site 1245469010356 catalytic triad [active] 1245469010357 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1245469010358 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469010359 Coenzyme A binding pocket [chemical binding]; other site 1245469010360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469010361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469010362 non-specific DNA binding site [nucleotide binding]; other site 1245469010363 salt bridge; other site 1245469010364 sequence-specific DNA binding site [nucleotide binding]; other site 1245469010365 Cupin domain; Region: Cupin_2; pfam07883 1245469010366 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1245469010367 CTP synthetase; Validated; Region: pyrG; PRK05380 1245469010368 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1245469010369 Catalytic site [active] 1245469010370 active site 1245469010371 UTP binding site [chemical binding]; other site 1245469010372 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1245469010373 active site 1245469010374 putative oxyanion hole; other site 1245469010375 catalytic triad [active] 1245469010376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469010377 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469010378 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469010379 dimer interface [polypeptide binding]; other site 1245469010380 phosphorylation site [posttranslational modification] 1245469010381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010382 ATP binding site [chemical binding]; other site 1245469010383 Mg2+ binding site [ion binding]; other site 1245469010384 G-X-G motif; other site 1245469010385 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469010386 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010387 active site 1245469010388 phosphorylation site [posttranslational modification] 1245469010389 intermolecular recognition site; other site 1245469010390 dimerization interface [polypeptide binding]; other site 1245469010391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469010392 DNA binding site [nucleotide binding] 1245469010393 NIPSNAP; Region: NIPSNAP; pfam07978 1245469010394 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1245469010395 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1245469010396 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1245469010397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469010398 putative substrate translocation pore; other site 1245469010399 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1245469010400 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1245469010401 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1245469010402 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1245469010403 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1245469010404 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1245469010405 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1245469010406 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1245469010407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1245469010408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469010409 UvsW helicase; Provisional; Region: uvsW; PHA02558 1245469010410 putative Mg++ binding site [ion binding]; other site 1245469010411 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 1245469010412 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1245469010413 enolase; Provisional; Region: eno; PRK00077 1245469010414 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1245469010415 dimer interface [polypeptide binding]; other site 1245469010416 metal binding site [ion binding]; metal-binding site 1245469010417 substrate binding pocket [chemical binding]; other site 1245469010418 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 1245469010419 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469010420 NADP binding site [chemical binding]; other site 1245469010421 dimer interface [polypeptide binding]; other site 1245469010422 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469010423 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469010424 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469010425 Predicted flavoprotein [General function prediction only]; Region: COG0431 1245469010426 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1245469010427 hypothetical protein; Provisional; Region: PRK06486 1245469010428 intersubunit interface [polypeptide binding]; other site 1245469010429 active site 1245469010430 Zn2+ binding site [ion binding]; other site 1245469010431 putative acetyltransferase; Provisional; Region: PRK03624 1245469010432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469010433 Coenzyme A binding pocket [chemical binding]; other site 1245469010434 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1245469010435 Septum formation initiator; Region: DivIC; pfam04977 1245469010436 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1245469010437 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1245469010438 tetramer interface [polypeptide binding]; other site 1245469010439 TPP-binding site [chemical binding]; other site 1245469010440 heterodimer interface [polypeptide binding]; other site 1245469010441 phosphorylation loop region [posttranslational modification] 1245469010442 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 1245469010443 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469010444 E3 interaction surface; other site 1245469010445 lipoyl attachment site [posttranslational modification]; other site 1245469010446 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1245469010447 alpha subunit interface [polypeptide binding]; other site 1245469010448 TPP binding site [chemical binding]; other site 1245469010449 heterodimer interface [polypeptide binding]; other site 1245469010450 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1245469010451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469010452 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 1245469010453 E3 interaction surface; other site 1245469010454 lipoyl attachment site [posttranslational modification]; other site 1245469010455 e3 binding domain; Region: E3_binding; pfam02817 1245469010456 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1245469010457 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1245469010458 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1245469010459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469010460 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1245469010461 threonine synthase; Validated; Region: PRK08197 1245469010462 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1245469010463 homodimer interface [polypeptide binding]; other site 1245469010464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469010465 catalytic residue [active] 1245469010466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469010467 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1245469010468 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469010469 Sel1-like repeats; Region: SEL1; smart00671 1245469010470 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1245469010471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469010472 Coenzyme A binding pocket [chemical binding]; other site 1245469010473 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469010474 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1245469010475 putative ligand binding site [chemical binding]; other site 1245469010476 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469010477 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 1245469010478 putative ligand binding site [chemical binding]; other site 1245469010479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469010480 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469010481 TM-ABC transporter signature motif; other site 1245469010482 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469010483 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469010484 TM-ABC transporter signature motif; other site 1245469010485 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1245469010486 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469010487 Walker A/P-loop; other site 1245469010488 ATP binding site [chemical binding]; other site 1245469010489 Q-loop/lid; other site 1245469010490 ABC transporter signature motif; other site 1245469010491 Walker B; other site 1245469010492 D-loop; other site 1245469010493 H-loop/switch region; other site 1245469010494 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469010495 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1245469010496 Walker A/P-loop; other site 1245469010497 ATP binding site [chemical binding]; other site 1245469010498 Q-loop/lid; other site 1245469010499 ABC transporter signature motif; other site 1245469010500 Walker B; other site 1245469010501 D-loop; other site 1245469010502 H-loop/switch region; other site 1245469010503 amidase; Provisional; Region: PRK07235 1245469010504 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469010505 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1245469010506 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1245469010507 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 1245469010508 dimer interface [polypeptide binding]; other site 1245469010509 catalytic residues [active] 1245469010510 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1245469010511 UreF; Region: UreF; pfam01730 1245469010512 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 1245469010513 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1245469010514 alpha-gamma subunit interface [polypeptide binding]; other site 1245469010515 beta-gamma subunit interface [polypeptide binding]; other site 1245469010516 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1245469010517 alpha-beta subunit interface [polypeptide binding]; other site 1245469010518 urease subunit alpha; Reviewed; Region: ureC; PRK13308 1245469010519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469010520 active site 1245469010521 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469010522 UreD urease accessory protein; Region: UreD; pfam01774 1245469010523 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1245469010524 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1245469010525 putative catalytic site [active] 1245469010526 putative phosphate binding site [ion binding]; other site 1245469010527 active site 1245469010528 metal binding site A [ion binding]; metal-binding site 1245469010529 DNA binding site [nucleotide binding] 1245469010530 putative AP binding site [nucleotide binding]; other site 1245469010531 putative metal binding site B [ion binding]; other site 1245469010532 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469010533 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469010534 active site 1245469010535 catalytic tetrad [active] 1245469010536 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1245469010537 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1245469010538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469010539 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469010540 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469010541 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469010542 putative effector binding pocket; other site 1245469010543 dimerization interface [polypeptide binding]; other site 1245469010544 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1245469010545 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469010546 active site 1245469010547 metal binding site [ion binding]; metal-binding site 1245469010548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469010549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469010550 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1245469010551 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1245469010552 PAS fold; Region: PAS_4; pfam08448 1245469010553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469010554 dimer interface [polypeptide binding]; other site 1245469010555 phosphorylation site [posttranslational modification] 1245469010556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010557 ATP binding site [chemical binding]; other site 1245469010558 Mg2+ binding site [ion binding]; other site 1245469010559 G-X-G motif; other site 1245469010560 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469010561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010562 active site 1245469010563 phosphorylation site [posttranslational modification] 1245469010564 intermolecular recognition site; other site 1245469010565 dimerization interface [polypeptide binding]; other site 1245469010566 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1245469010567 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 1245469010568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469010569 Zn2+ binding site [ion binding]; other site 1245469010570 Mg2+ binding site [ion binding]; other site 1245469010571 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1245469010572 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1245469010573 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1245469010574 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1245469010575 active site 1245469010576 HIGH motif; other site 1245469010577 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469010578 KMSK motif region; other site 1245469010579 tRNA binding surface [nucleotide binding]; other site 1245469010580 DALR anticodon binding domain; Region: DALR_1; smart00836 1245469010581 anticodon binding site; other site 1245469010582 Sporulation related domain; Region: SPOR; pfam05036 1245469010583 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1245469010584 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1245469010585 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1245469010586 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 1245469010587 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 1245469010588 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1245469010589 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 1245469010590 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1245469010591 seryl-tRNA synthetase; Provisional; Region: PRK05431 1245469010592 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1245469010593 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1245469010594 dimer interface [polypeptide binding]; other site 1245469010595 active site 1245469010596 motif 1; other site 1245469010597 motif 2; other site 1245469010598 motif 3; other site 1245469010599 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1245469010600 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469010601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010602 active site 1245469010603 phosphorylation site [posttranslational modification] 1245469010604 intermolecular recognition site; other site 1245469010605 dimerization interface [polypeptide binding]; other site 1245469010606 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1245469010607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469010608 S-adenosylmethionine binding site [chemical binding]; other site 1245469010609 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1245469010610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1245469010611 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1245469010612 Peptidase family M23; Region: Peptidase_M23; pfam01551 1245469010613 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 1245469010614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469010615 Walker A motif; other site 1245469010616 ATP binding site [chemical binding]; other site 1245469010617 Walker B motif; other site 1245469010618 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1245469010619 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1245469010620 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1245469010621 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1245469010622 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1245469010623 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1245469010624 Protein export membrane protein; Region: SecD_SecF; pfam02355 1245469010625 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 1245469010626 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 1245469010627 substrate binding pocket [chemical binding]; other site 1245469010628 substrate-Mg2+ binding site; other site 1245469010629 aspartate-rich region 1; other site 1245469010630 aspartate-rich region 2; other site 1245469010631 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1245469010632 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1245469010633 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1245469010634 active site 1245469010635 iron coordination sites [ion binding]; other site 1245469010636 substrate binding pocket [chemical binding]; other site 1245469010637 serine/threonine protein kinase; Provisional; Region: PRK09188 1245469010638 serine/threonine protein kinase; Provisional; Region: PRK12274 1245469010639 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469010640 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1245469010641 Glucose inhibited division protein A; Region: GIDA; pfam01134 1245469010642 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1245469010643 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1245469010644 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469010645 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469010646 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1245469010647 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 1245469010648 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 1245469010649 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1245469010650 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1245469010651 acyl-CoA synthetase; Validated; Region: PRK07470 1245469010652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469010653 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469010654 acyl-activating enzyme (AAE) consensus motif; other site 1245469010655 acyl-activating enzyme (AAE) consensus motif; other site 1245469010656 putative AMP binding site [chemical binding]; other site 1245469010657 putative active site [active] 1245469010658 putative CoA binding site [chemical binding]; other site 1245469010659 Predicted ATPase [General function prediction only]; Region: COG3910 1245469010660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1245469010661 Walker A/P-loop; other site 1245469010662 ATP binding site [chemical binding]; other site 1245469010663 Q-loop/lid; other site 1245469010664 ABC transporter signature motif; other site 1245469010665 Walker B; other site 1245469010666 D-loop; other site 1245469010667 H-loop/switch region; other site 1245469010668 Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; pfam09939 1245469010669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469010670 dimerization interface [polypeptide binding]; other site 1245469010671 putative DNA binding site [nucleotide binding]; other site 1245469010672 putative Zn2+ binding site [ion binding]; other site 1245469010673 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1245469010674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469010675 NAD(P) binding site [chemical binding]; other site 1245469010676 active site 1245469010677 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469010678 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 1245469010679 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1245469010680 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1245469010681 Transcriptional regulator; Region: Transcrip_reg; cl00361 1245469010682 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1245469010683 active site 1245469010684 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1245469010685 TSCPD domain; Region: TSCPD; pfam12637 1245469010686 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469010687 EamA-like transporter family; Region: EamA; pfam00892 1245469010688 CHASE3 domain; Region: CHASE3; pfam05227 1245469010689 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1245469010690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469010691 putative active site [active] 1245469010692 heme pocket [chemical binding]; other site 1245469010693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469010694 dimer interface [polypeptide binding]; other site 1245469010695 phosphorylation site [posttranslational modification] 1245469010696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010697 ATP binding site [chemical binding]; other site 1245469010698 Mg2+ binding site [ion binding]; other site 1245469010699 G-X-G motif; other site 1245469010700 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469010701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010702 active site 1245469010703 phosphorylation site [posttranslational modification] 1245469010704 intermolecular recognition site; other site 1245469010705 dimerization interface [polypeptide binding]; other site 1245469010706 CHASE3 domain; Region: CHASE3; pfam05227 1245469010707 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1245469010708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469010709 putative active site [active] 1245469010710 heme pocket [chemical binding]; other site 1245469010711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469010712 dimer interface [polypeptide binding]; other site 1245469010713 phosphorylation site [posttranslational modification] 1245469010714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010715 ATP binding site [chemical binding]; other site 1245469010716 G-X-G motif; other site 1245469010717 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469010718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010719 active site 1245469010720 phosphorylation site [posttranslational modification] 1245469010721 intermolecular recognition site; other site 1245469010722 dimerization interface [polypeptide binding]; other site 1245469010723 BA14K-like protein; Region: BA14K; pfam07886 1245469010724 NADH dehydrogenase; Validated; Region: PRK08183 1245469010725 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1245469010726 conserved cys residue [active] 1245469010727 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1245469010728 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1245469010729 conserved cys residue [active] 1245469010730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469010731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469010732 active site 1245469010733 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469010734 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1245469010735 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469010736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469010737 dimer interface [polypeptide binding]; other site 1245469010738 conserved gate region; other site 1245469010739 putative PBP binding loops; other site 1245469010740 ABC-ATPase subunit interface; other site 1245469010741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469010742 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469010743 substrate binding pocket [chemical binding]; other site 1245469010744 membrane-bound complex binding site; other site 1245469010745 hinge residues; other site 1245469010746 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1245469010747 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1245469010748 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1245469010749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469010750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469010751 homodimer interface [polypeptide binding]; other site 1245469010752 catalytic residue [active] 1245469010753 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469010754 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1245469010755 substrate binding pocket [chemical binding]; other site 1245469010756 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469010757 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1245469010758 classical (c) SDRs; Region: SDR_c; cd05233 1245469010759 NAD(P) binding site [chemical binding]; other site 1245469010760 active site 1245469010761 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 1245469010762 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1245469010763 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469010764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010765 active site 1245469010766 phosphorylation site [posttranslational modification] 1245469010767 intermolecular recognition site; other site 1245469010768 dimerization interface [polypeptide binding]; other site 1245469010769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469010770 Histidine kinase; Region: HisKA_2; pfam07568 1245469010771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010772 ATP binding site [chemical binding]; other site 1245469010773 Mg2+ binding site [ion binding]; other site 1245469010774 G-X-G motif; other site 1245469010775 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469010776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469010777 active site 1245469010778 phosphorylation site [posttranslational modification] 1245469010779 intermolecular recognition site; other site 1245469010780 dimerization interface [polypeptide binding]; other site 1245469010781 CHASE3 domain; Region: CHASE3; pfam05227 1245469010782 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469010783 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1245469010784 dimer interface [polypeptide binding]; other site 1245469010785 phosphorylation site [posttranslational modification] 1245469010786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010787 ATP binding site [chemical binding]; other site 1245469010788 Mg2+ binding site [ion binding]; other site 1245469010789 G-X-G motif; other site 1245469010790 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1245469010791 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469010792 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1245469010793 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1245469010794 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1245469010795 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1245469010796 carboxyltransferase (CT) interaction site; other site 1245469010797 biotinylation site [posttranslational modification]; other site 1245469010798 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1245469010799 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1245469010800 trimer interface [polypeptide binding]; other site 1245469010801 active site 1245469010802 dimer interface [polypeptide binding]; other site 1245469010803 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1245469010804 tricarballylate utilization protein B; Provisional; Region: PRK15033 1245469010805 tricarballylate dehydrogenase; Validated; Region: PRK08274 1245469010806 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469010807 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469010808 DNA-binding site [nucleotide binding]; DNA binding site 1245469010809 FCD domain; Region: FCD; pfam07729 1245469010810 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1245469010811 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 1245469010812 catalytic residues [active] 1245469010813 Peptidase family M48; Region: Peptidase_M48; cl12018 1245469010814 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469010815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469010816 TPR motif; other site 1245469010817 binding surface 1245469010818 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1245469010819 aspartate aminotransferase; Provisional; Region: PRK05764 1245469010820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469010821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469010822 homodimer interface [polypeptide binding]; other site 1245469010823 catalytic residue [active] 1245469010824 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1245469010825 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469010826 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1245469010827 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1245469010828 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1245469010829 AMIN domain; Region: AMIN; pfam11741 1245469010830 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1245469010831 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1245469010832 active site 1245469010833 metal binding site [ion binding]; metal-binding site 1245469010834 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1245469010835 Transglycosylase; Region: Transgly; pfam00912 1245469010836 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1245469010837 peptide chain release factor 2; Provisional; Region: PRK07342 1245469010838 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1245469010839 RF-1 domain; Region: RF-1; pfam00472 1245469010840 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1245469010841 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469010842 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1245469010843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469010844 active site 1245469010845 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1245469010846 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1245469010847 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1245469010848 TrkA-N domain; Region: TrkA_N; pfam02254 1245469010849 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 1245469010850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469010851 PAS domain; Region: PAS_9; pfam13426 1245469010852 putative active site [active] 1245469010853 heme pocket [chemical binding]; other site 1245469010854 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469010855 Tar ligand binding domain homologue; Region: TarH; pfam02203 1245469010856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469010857 dimerization interface [polypeptide binding]; other site 1245469010858 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469010859 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469010860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469010861 dimer interface [polypeptide binding]; other site 1245469010862 putative CheW interface [polypeptide binding]; other site 1245469010863 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1245469010864 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1245469010865 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469010866 DNA-binding site [nucleotide binding]; DNA binding site 1245469010867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469010868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469010869 homodimer interface [polypeptide binding]; other site 1245469010870 catalytic residue [active] 1245469010871 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 1245469010872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469010873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469010874 homodimer interface [polypeptide binding]; other site 1245469010875 catalytic residue [active] 1245469010876 cystathionine beta-lyase; Provisional; Region: PRK07050 1245469010877 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469010878 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469010879 catalytic residue [active] 1245469010880 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 1245469010881 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1245469010882 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1245469010883 Peptidase family M23; Region: Peptidase_M23; pfam01551 1245469010884 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1245469010885 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1245469010886 catalytic triad [active] 1245469010887 Protein of unknown function; Region: DUF3971; pfam13116 1245469010888 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1245469010889 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1245469010890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469010891 dimerization interface [polypeptide binding]; other site 1245469010892 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469010893 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469010894 dimer interface [polypeptide binding]; other site 1245469010895 putative CheW interface [polypeptide binding]; other site 1245469010896 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469010897 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1245469010898 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1245469010899 active site 1245469010900 HIGH motif; other site 1245469010901 dimer interface [polypeptide binding]; other site 1245469010902 KMSKS motif; other site 1245469010903 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469010904 RNA binding surface [nucleotide binding]; other site 1245469010905 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1245469010906 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469010907 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1245469010908 C-terminal domain interface [polypeptide binding]; other site 1245469010909 GSH binding site (G-site) [chemical binding]; other site 1245469010910 dimer interface [polypeptide binding]; other site 1245469010911 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1245469010912 N-terminal domain interface [polypeptide binding]; other site 1245469010913 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1245469010914 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469010915 LytTr DNA-binding domain; Region: LytTR; smart00850 1245469010916 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1245469010917 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1245469010918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469010919 catalytic residue [active] 1245469010920 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1245469010921 putative ABC transporter; Region: ycf24; CHL00085 1245469010922 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1245469010923 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1245469010924 Walker A/P-loop; other site 1245469010925 ATP binding site [chemical binding]; other site 1245469010926 Q-loop/lid; other site 1245469010927 ABC transporter signature motif; other site 1245469010928 Walker B; other site 1245469010929 D-loop; other site 1245469010930 H-loop/switch region; other site 1245469010931 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1245469010932 FeS assembly protein SufD; Region: sufD; TIGR01981 1245469010933 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1245469010934 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1245469010935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469010936 catalytic residue [active] 1245469010937 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 1245469010938 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1245469010939 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1245469010940 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469010941 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469010942 metal binding site [ion binding]; metal-binding site 1245469010943 active site 1245469010944 I-site; other site 1245469010945 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1245469010946 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1245469010947 ATP binding site [chemical binding]; other site 1245469010948 Mg++ binding site [ion binding]; other site 1245469010949 motif III; other site 1245469010950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469010951 nucleotide binding region [chemical binding]; other site 1245469010952 ATP-binding site [chemical binding]; other site 1245469010953 Caspase domain; Region: Peptidase_C14; pfam00656 1245469010954 active site 1245469010955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469010956 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1245469010957 NAD(P) binding site [chemical binding]; other site 1245469010958 active site 1245469010959 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1245469010960 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1245469010961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469010962 ATP binding site [chemical binding]; other site 1245469010963 Mg2+ binding site [ion binding]; other site 1245469010964 G-X-G motif; other site 1245469010965 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1245469010966 anchoring element; other site 1245469010967 dimer interface [polypeptide binding]; other site 1245469010968 ATP binding site [chemical binding]; other site 1245469010969 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1245469010970 active site 1245469010971 metal binding site [ion binding]; metal-binding site 1245469010972 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1245469010973 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1245469010974 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1245469010975 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1245469010976 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 1245469010977 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1245469010978 threonine dehydratase; Provisional; Region: PRK07334 1245469010979 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1245469010980 tetramer interface [polypeptide binding]; other site 1245469010981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469010982 catalytic residue [active] 1245469010983 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1245469010984 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469010985 classical (c) SDRs; Region: SDR_c; cd05233 1245469010986 NAD(P) binding site [chemical binding]; other site 1245469010987 active site 1245469010988 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469010989 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469010990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469010991 dimer interface [polypeptide binding]; other site 1245469010992 conserved gate region; other site 1245469010993 putative PBP binding loops; other site 1245469010994 ABC-ATPase subunit interface; other site 1245469010995 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469010996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469010997 dimer interface [polypeptide binding]; other site 1245469010998 conserved gate region; other site 1245469010999 putative PBP binding loops; other site 1245469011000 ABC-ATPase subunit interface; other site 1245469011001 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1245469011002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469011003 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1245469011004 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1245469011005 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1245469011006 DNA binding site [nucleotide binding] 1245469011007 domain linker motif; other site 1245469011008 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1245469011009 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469011010 putative ligand binding site [chemical binding]; other site 1245469011011 MAPEG family; Region: MAPEG; pfam01124 1245469011012 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 1245469011013 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1245469011014 aminotransferase; Validated; Region: PRK09148 1245469011015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469011016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469011017 homodimer interface [polypeptide binding]; other site 1245469011018 catalytic residue [active] 1245469011019 homoserine dehydrogenase; Provisional; Region: PRK06349 1245469011020 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1245469011021 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1245469011022 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1245469011023 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1245469011024 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1245469011025 putative active site [active] 1245469011026 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1245469011027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469011028 motif II; other site 1245469011029 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469011030 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1245469011031 DHH family; Region: DHH; pfam01368 1245469011032 DHHA1 domain; Region: DHHA1; pfam02272 1245469011033 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469011034 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469011035 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1245469011036 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 1245469011037 putative metal binding site [ion binding]; other site 1245469011038 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1245469011039 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1245469011040 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1245469011041 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469011042 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469011043 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469011044 MarR family; Region: MarR_2; pfam12802 1245469011045 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469011046 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1245469011047 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1245469011048 Peptidase family M23; Region: Peptidase_M23; pfam01551 1245469011049 elongation factor P; Validated; Region: PRK00529 1245469011050 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1245469011051 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1245469011052 RNA binding site [nucleotide binding]; other site 1245469011053 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1245469011054 RNA binding site [nucleotide binding]; other site 1245469011055 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1245469011056 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1245469011057 motif 1; other site 1245469011058 dimer interface [polypeptide binding]; other site 1245469011059 active site 1245469011060 motif 2; other site 1245469011061 motif 3; other site 1245469011062 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1245469011063 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469011064 FeS/SAM binding site; other site 1245469011065 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1245469011066 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469011067 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1245469011068 NAD(P) binding site [chemical binding]; other site 1245469011069 catalytic residues [active] 1245469011070 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1245469011071 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1245469011072 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1245469011073 M6 family metalloprotease domain; Region: M6dom_TIGR03296 1245469011074 Protease prsW family; Region: PrsW-protease; pfam13367 1245469011075 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1245469011076 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1245469011077 substrate-cofactor binding pocket; other site 1245469011078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469011079 catalytic residue [active] 1245469011080 Hemerythrin-like domain; Region: Hr-like; cd12108 1245469011081 Fe binding site [ion binding]; other site 1245469011082 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 1245469011083 [2Fe-2S] cluster binding site [ion binding]; other site 1245469011084 PilZ domain; Region: PilZ; pfam07238 1245469011085 Porin subfamily; Region: Porin_2; pfam02530 1245469011086 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469011087 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1245469011088 putative C-terminal domain interface [polypeptide binding]; other site 1245469011089 putative GSH binding site (G-site) [chemical binding]; other site 1245469011090 putative dimer interface [polypeptide binding]; other site 1245469011091 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 1245469011092 putative N-terminal domain interface [polypeptide binding]; other site 1245469011093 putative dimer interface [polypeptide binding]; other site 1245469011094 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469011095 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469011096 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1245469011097 dimer interface [polypeptide binding]; other site 1245469011098 active site 1245469011099 metal binding site [ion binding]; metal-binding site 1245469011100 glutathione binding site [chemical binding]; other site 1245469011101 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1245469011102 IHF dimer interface [polypeptide binding]; other site 1245469011103 IHF - DNA interface [nucleotide binding]; other site 1245469011104 NAD-dependent deacetylase; Provisional; Region: PRK00481 1245469011105 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1245469011106 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469011107 DNA-binding site [nucleotide binding]; DNA binding site 1245469011108 RNA-binding motif; other site 1245469011109 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469011110 DNA-binding site [nucleotide binding]; DNA binding site 1245469011111 RNA-binding motif; other site 1245469011112 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469011113 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469011114 Walker A/P-loop; other site 1245469011115 ATP binding site [chemical binding]; other site 1245469011116 Q-loop/lid; other site 1245469011117 ABC transporter signature motif; other site 1245469011118 Walker B; other site 1245469011119 D-loop; other site 1245469011120 H-loop/switch region; other site 1245469011121 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1245469011122 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1245469011123 FtsX-like permease family; Region: FtsX; pfam02687 1245469011124 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469011125 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469011126 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469011127 OpgC protein; Region: OpgC_C; pfam10129 1245469011128 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1245469011129 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 1245469011130 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1245469011131 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469011132 putative DNA binding site [nucleotide binding]; other site 1245469011133 putative Zn2+ binding site [ion binding]; other site 1245469011134 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469011135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469011136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469011137 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1245469011138 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1245469011139 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1245469011140 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1245469011141 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469011142 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469011143 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1245469011144 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1245469011145 carboxyltransferase (CT) interaction site; other site 1245469011146 biotinylation site [posttranslational modification]; other site 1245469011147 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1245469011148 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1245469011149 active site 1245469011150 catalytic residues [active] 1245469011151 metal binding site [ion binding]; metal-binding site 1245469011152 DctM-like transporters; Region: DctM; pfam06808 1245469011153 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469011154 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1245469011155 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469011156 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1245469011157 nudix motif; other site 1245469011158 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1245469011159 apolar tunnel; other site 1245469011160 heme binding site [chemical binding]; other site 1245469011161 dimerization interface [polypeptide binding]; other site 1245469011162 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469011163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011164 active site 1245469011165 phosphorylation site [posttranslational modification] 1245469011166 intermolecular recognition site; other site 1245469011167 dimerization interface [polypeptide binding]; other site 1245469011168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469011169 sequence-specific DNA binding site [nucleotide binding]; other site 1245469011170 salt bridge; other site 1245469011171 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1245469011172 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1245469011173 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1245469011174 isocitrate lyase; Provisional; Region: PRK15063 1245469011175 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1245469011176 tetramer interface [polypeptide binding]; other site 1245469011177 active site 1245469011178 Mg2+/Mn2+ binding site [ion binding]; other site 1245469011179 isocitrate lyase; Region: PLN02892 1245469011180 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1245469011181 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1245469011182 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1245469011183 NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435 1245469011184 Ligand binding site; other site 1245469011185 DXD motif; other site 1245469011186 Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309 1245469011187 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 1245469011188 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1245469011189 Substrate binding site; other site 1245469011190 Mg++ binding site; other site 1245469011191 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1245469011192 active site 1245469011193 substrate binding site [chemical binding]; other site 1245469011194 CoA binding site [chemical binding]; other site 1245469011195 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1245469011196 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1245469011197 glutaminase active site [active] 1245469011198 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1245469011199 dimer interface [polypeptide binding]; other site 1245469011200 active site 1245469011201 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1245469011202 dimer interface [polypeptide binding]; other site 1245469011203 active site 1245469011204 LysE type translocator; Region: LysE; cl00565 1245469011205 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1245469011206 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 1245469011207 putative dimer interface [polypeptide binding]; other site 1245469011208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469011209 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 1245469011210 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 1245469011211 active site 1245469011212 catalytic triad [active] 1245469011213 oxyanion hole [active] 1245469011214 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469011215 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469011216 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1245469011217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469011218 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1245469011219 dimer interface [polypeptide binding]; other site 1245469011220 ligand binding site [chemical binding]; other site 1245469011221 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1245469011222 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1245469011223 ssDNA binding site; other site 1245469011224 generic binding surface II; other site 1245469011225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469011226 ATP binding site [chemical binding]; other site 1245469011227 putative Mg++ binding site [ion binding]; other site 1245469011228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469011229 nucleotide binding region [chemical binding]; other site 1245469011230 ATP-binding site [chemical binding]; other site 1245469011231 Uncharacterized conserved protein [Function unknown]; Region: COG2938 1245469011232 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1245469011233 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1245469011234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469011235 ATP binding site [chemical binding]; other site 1245469011236 putative Mg++ binding site [ion binding]; other site 1245469011237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469011238 nucleotide binding region [chemical binding]; other site 1245469011239 ATP-binding site [chemical binding]; other site 1245469011240 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1245469011241 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1245469011242 metal binding site [ion binding]; metal-binding site 1245469011243 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1245469011244 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469011245 acyl-activating enzyme (AAE) consensus motif; other site 1245469011246 active site 1245469011247 AMP binding site [chemical binding]; other site 1245469011248 CoA binding site [chemical binding]; other site 1245469011249 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1245469011250 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1245469011251 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 1245469011252 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 1245469011253 Predicted permeases [General function prediction only]; Region: COG0679 1245469011254 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 1245469011255 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469011256 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1245469011257 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1245469011258 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1245469011259 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1245469011260 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1245469011261 NADP binding site [chemical binding]; other site 1245469011262 dimer interface [polypeptide binding]; other site 1245469011263 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 1245469011264 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469011265 inhibitor-cofactor binding pocket; inhibition site 1245469011266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469011267 catalytic residue [active] 1245469011268 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469011269 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1245469011270 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1245469011271 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469011272 FeS/SAM binding site; other site 1245469011273 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1245469011274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011275 active site 1245469011276 phosphorylation site [posttranslational modification] 1245469011277 intermolecular recognition site; other site 1245469011278 ANTAR domain; Region: ANTAR; pfam03861 1245469011279 NMT1-like family; Region: NMT1_2; pfam13379 1245469011280 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469011281 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 1245469011282 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1245469011283 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1245469011284 sulfite reductase; Provisional; Region: PRK06214 1245469011285 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1245469011286 FAD binding pocket [chemical binding]; other site 1245469011287 FAD binding motif [chemical binding]; other site 1245469011288 catalytic residues [active] 1245469011289 NAD binding pocket [chemical binding]; other site 1245469011290 phosphate binding motif [ion binding]; other site 1245469011291 beta-alpha-beta structure motif; other site 1245469011292 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1245469011293 putative active site [active] 1245469011294 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1245469011295 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1245469011296 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1245469011297 hypothetical protein; Validated; Region: PRK08245 1245469011298 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1245469011299 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469011300 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1245469011301 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469011302 putative DNA binding site [nucleotide binding]; other site 1245469011303 putative Zn2+ binding site [ion binding]; other site 1245469011304 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469011305 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1245469011306 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1245469011307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469011308 catalytic residue [active] 1245469011309 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1245469011310 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469011311 ligand binding site [chemical binding]; other site 1245469011312 dimer interface [polypeptide binding]; other site 1245469011313 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1245469011314 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1245469011315 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1245469011316 DNA binding site [nucleotide binding] 1245469011317 active site 1245469011318 Int/Topo IB signature motif; other site 1245469011319 catalytic residues [active] 1245469011320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469011321 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469011322 substrate binding pocket [chemical binding]; other site 1245469011323 membrane-bound complex binding site; other site 1245469011324 hinge residues; other site 1245469011325 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1245469011326 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469011327 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1245469011328 ligand binding site [chemical binding]; other site 1245469011329 NAD binding site [chemical binding]; other site 1245469011330 dimerization interface [polypeptide binding]; other site 1245469011331 catalytic site [active] 1245469011332 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1245469011333 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1245469011334 Walker A/P-loop; other site 1245469011335 ATP binding site [chemical binding]; other site 1245469011336 Q-loop/lid; other site 1245469011337 ABC transporter signature motif; other site 1245469011338 Walker B; other site 1245469011339 D-loop; other site 1245469011340 H-loop/switch region; other site 1245469011341 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469011342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469011343 dimer interface [polypeptide binding]; other site 1245469011344 conserved gate region; other site 1245469011345 putative PBP binding loops; other site 1245469011346 ABC-ATPase subunit interface; other site 1245469011347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469011348 dimer interface [polypeptide binding]; other site 1245469011349 conserved gate region; other site 1245469011350 putative PBP binding loops; other site 1245469011351 ABC-ATPase subunit interface; other site 1245469011352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469011353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469011354 LTXXQ motif family protein; Region: LTXXQ; pfam07813 1245469011355 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1245469011356 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1245469011357 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1245469011358 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469011359 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1245469011360 Phage Tail Collar Domain; Region: Collar; pfam07484 1245469011361 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1245469011362 Phage Tail Collar Domain; Region: Collar; pfam07484 1245469011363 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1245469011364 Phage Tail Collar Domain; Region: Collar; pfam07484 1245469011365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469011366 Coenzyme A binding pocket [chemical binding]; other site 1245469011367 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469011368 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469011369 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1245469011370 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1245469011371 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1245469011372 thymidylate kinase; Validated; Region: tmk; PRK00698 1245469011373 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1245469011374 TMP-binding site; other site 1245469011375 ATP-binding site [chemical binding]; other site 1245469011376 DNA polymerase III subunit delta'; Validated; Region: PRK07471 1245469011377 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1245469011378 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1245469011379 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1245469011380 active site 1245469011381 HIGH motif; other site 1245469011382 KMSKS motif; other site 1245469011383 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1245469011384 tRNA binding surface [nucleotide binding]; other site 1245469011385 anticodon binding site; other site 1245469011386 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1245469011387 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1245469011388 active site 1245469011389 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1245469011390 putative hydrolase; Provisional; Region: PRK02113 1245469011391 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1245469011392 acyl-CoA synthetase; Validated; Region: PRK08162 1245469011393 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 1245469011394 acyl-activating enzyme (AAE) consensus motif; other site 1245469011395 putative active site [active] 1245469011396 AMP binding site [chemical binding]; other site 1245469011397 putative CoA binding site [chemical binding]; other site 1245469011398 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1245469011399 DctM-like transporters; Region: DctM; pfam06808 1245469011400 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469011401 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469011402 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1245469011403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469011404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469011405 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469011406 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469011407 Walker A/P-loop; other site 1245469011408 ATP binding site [chemical binding]; other site 1245469011409 Q-loop/lid; other site 1245469011410 ABC transporter signature motif; other site 1245469011411 Walker B; other site 1245469011412 D-loop; other site 1245469011413 H-loop/switch region; other site 1245469011414 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469011415 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469011416 Walker A/P-loop; other site 1245469011417 ATP binding site [chemical binding]; other site 1245469011418 Q-loop/lid; other site 1245469011419 ABC transporter signature motif; other site 1245469011420 Walker B; other site 1245469011421 D-loop; other site 1245469011422 H-loop/switch region; other site 1245469011423 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469011424 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469011425 TM-ABC transporter signature motif; other site 1245469011426 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469011427 TM-ABC transporter signature motif; other site 1245469011428 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469011429 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_10; cd06345 1245469011430 putative ligand binding site [chemical binding]; other site 1245469011431 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1245469011432 Peptidase family M50; Region: Peptidase_M50; pfam02163 1245469011433 active site 1245469011434 putative substrate binding region [chemical binding]; other site 1245469011435 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 1245469011436 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1245469011437 beta-galactosidase; Region: BGL; TIGR03356 1245469011438 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 1245469011439 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1245469011440 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1245469011441 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1245469011442 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 1245469011443 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1245469011444 Ligand Binding Site [chemical binding]; other site 1245469011445 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1245469011446 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1245469011447 homodimer interface [polypeptide binding]; other site 1245469011448 metal binding site [ion binding]; metal-binding site 1245469011449 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1245469011450 homodimer interface [polypeptide binding]; other site 1245469011451 active site 1245469011452 putative chemical substrate binding site [chemical binding]; other site 1245469011453 metal binding site [ion binding]; metal-binding site 1245469011454 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469011455 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469011456 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1245469011457 putative dimerization interface [polypeptide binding]; other site 1245469011458 benzoate transport; Region: 2A0115; TIGR00895 1245469011459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469011460 putative substrate translocation pore; other site 1245469011461 hypothetical protein; Provisional; Region: PRK06126 1245469011462 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469011463 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1245469011464 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469011465 PYR/PP interface [polypeptide binding]; other site 1245469011466 dimer interface [polypeptide binding]; other site 1245469011467 TPP binding site [chemical binding]; other site 1245469011468 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1245469011469 TPP-binding site [chemical binding]; other site 1245469011470 dimer interface [polypeptide binding]; other site 1245469011471 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1245469011472 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1245469011473 HflX GTPase family; Region: HflX; cd01878 1245469011474 G1 box; other site 1245469011475 GTP/Mg2+ binding site [chemical binding]; other site 1245469011476 Switch I region; other site 1245469011477 G2 box; other site 1245469011478 G3 box; other site 1245469011479 Switch II region; other site 1245469011480 G4 box; other site 1245469011481 G5 box; other site 1245469011482 bacterial Hfq-like; Region: Hfq; cd01716 1245469011483 hexamer interface [polypeptide binding]; other site 1245469011484 Sm1 motif; other site 1245469011485 RNA binding site [nucleotide binding]; other site 1245469011486 Sm2 motif; other site 1245469011487 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469011488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011489 active site 1245469011490 phosphorylation site [posttranslational modification] 1245469011491 intermolecular recognition site; other site 1245469011492 dimerization interface [polypeptide binding]; other site 1245469011493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469011494 Walker A motif; other site 1245469011495 ATP binding site [chemical binding]; other site 1245469011496 Walker B motif; other site 1245469011497 arginine finger; other site 1245469011498 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469011499 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 1245469011500 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011501 dimerization interface [polypeptide binding]; other site 1245469011502 PAS domain; Region: PAS; smart00091 1245469011503 putative active site [active] 1245469011504 heme pocket [chemical binding]; other site 1245469011505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469011506 dimer interface [polypeptide binding]; other site 1245469011507 phosphorylation site [posttranslational modification] 1245469011508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469011509 ATP binding site [chemical binding]; other site 1245469011510 Mg2+ binding site [ion binding]; other site 1245469011511 G-X-G motif; other site 1245469011512 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1245469011513 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469011514 hypothetical protein; Validated; Region: PRK06201 1245469011515 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1245469011516 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469011517 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1245469011518 ligand binding site [chemical binding]; other site 1245469011519 NAD binding site [chemical binding]; other site 1245469011520 dimerization interface [polypeptide binding]; other site 1245469011521 catalytic site [active] 1245469011522 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1245469011523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469011524 putative substrate translocation pore; other site 1245469011525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469011526 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469011527 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469011528 active site 1245469011529 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1245469011530 Strictosidine synthase; Region: Str_synth; pfam03088 1245469011531 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469011532 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1245469011533 active site 1245469011534 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1245469011535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469011536 putative substrate translocation pore; other site 1245469011537 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1245469011538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011539 active site 1245469011540 phosphorylation site [posttranslational modification] 1245469011541 intermolecular recognition site; other site 1245469011542 dimerization interface [polypeptide binding]; other site 1245469011543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469011544 Walker A motif; other site 1245469011545 ATP binding site [chemical binding]; other site 1245469011546 Walker B motif; other site 1245469011547 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1245469011548 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1245469011549 PAS domain; Region: PAS; smart00091 1245469011550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469011551 dimer interface [polypeptide binding]; other site 1245469011552 phosphorylation site [posttranslational modification] 1245469011553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469011554 ATP binding site [chemical binding]; other site 1245469011555 Mg2+ binding site [ion binding]; other site 1245469011556 G-X-G motif; other site 1245469011557 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1245469011558 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1245469011559 FMN binding site [chemical binding]; other site 1245469011560 active site 1245469011561 catalytic residues [active] 1245469011562 substrate binding site [chemical binding]; other site 1245469011563 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1245469011564 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1245469011565 substrate binding site; other site 1245469011566 dimer interface; other site 1245469011567 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1245469011568 homotrimer interaction site [polypeptide binding]; other site 1245469011569 zinc binding site [ion binding]; other site 1245469011570 CDP-binding sites; other site 1245469011571 Competence-damaged protein; Region: CinA; pfam02464 1245469011572 PAS domain; Region: PAS_9; pfam13426 1245469011573 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469011574 putative active site [active] 1245469011575 heme pocket [chemical binding]; other site 1245469011576 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469011577 dimer interface [polypeptide binding]; other site 1245469011578 putative CheW interface [polypeptide binding]; other site 1245469011579 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1245469011580 putative coenzyme Q binding site [chemical binding]; other site 1245469011581 lipoyl synthase; Provisional; Region: PRK05481 1245469011582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469011583 FeS/SAM binding site; other site 1245469011584 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1245469011585 DNA binding site [nucleotide binding] 1245469011586 active site 1245469011587 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1245469011588 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1245469011589 HIGH motif; other site 1245469011590 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1245469011591 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1245469011592 active site 1245469011593 KMSKS motif; other site 1245469011594 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1245469011595 tRNA binding surface [nucleotide binding]; other site 1245469011596 anticodon binding site; other site 1245469011597 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1245469011598 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 1245469011599 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1245469011600 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1245469011601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469011602 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1245469011603 nudix motif; other site 1245469011604 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1245469011605 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1245469011606 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469011607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011608 active site 1245469011609 phosphorylation site [posttranslational modification] 1245469011610 intermolecular recognition site; other site 1245469011611 dimerization interface [polypeptide binding]; other site 1245469011612 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469011613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011614 active site 1245469011615 phosphorylation site [posttranslational modification] 1245469011616 intermolecular recognition site; other site 1245469011617 dimerization interface [polypeptide binding]; other site 1245469011618 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469011619 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1245469011620 dimer interface [polypeptide binding]; other site 1245469011621 Trp docking motif [polypeptide binding]; other site 1245469011622 active site 1245469011623 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1245469011624 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1245469011625 iron-sulfur cluster [ion binding]; other site 1245469011626 [2Fe-2S] cluster binding site [ion binding]; other site 1245469011627 DTW domain; Region: DTW; cl01221 1245469011628 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1245469011629 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1245469011630 Protein export membrane protein; Region: SecD_SecF; cl14618 1245469011631 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469011632 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469011633 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469011634 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1245469011635 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1245469011636 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469011637 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1245469011638 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1245469011639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469011640 S-adenosylmethionine binding site [chemical binding]; other site 1245469011641 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1245469011642 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1245469011643 dimer interface [polypeptide binding]; other site 1245469011644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469011645 catalytic residue [active] 1245469011646 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1245469011647 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1245469011648 Walker A/P-loop; other site 1245469011649 ATP binding site [chemical binding]; other site 1245469011650 Q-loop/lid; other site 1245469011651 ABC transporter signature motif; other site 1245469011652 Walker B; other site 1245469011653 D-loop; other site 1245469011654 H-loop/switch region; other site 1245469011655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469011656 dimer interface [polypeptide binding]; other site 1245469011657 conserved gate region; other site 1245469011658 putative PBP binding loops; other site 1245469011659 ABC-ATPase subunit interface; other site 1245469011660 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1245469011661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469011662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469011663 dimer interface [polypeptide binding]; other site 1245469011664 conserved gate region; other site 1245469011665 putative PBP binding loops; other site 1245469011666 ABC-ATPase subunit interface; other site 1245469011667 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1245469011668 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469011669 substrate binding pocket [chemical binding]; other site 1245469011670 membrane-bound complex binding site; other site 1245469011671 hinge residues; other site 1245469011672 cystathionine beta-lyase; Provisional; Region: PRK05967 1245469011673 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1245469011674 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469011675 catalytic residue [active] 1245469011676 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1245469011677 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1245469011678 PhoU domain; Region: PhoU; pfam01895 1245469011679 PhoU domain; Region: PhoU; pfam01895 1245469011680 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 1245469011681 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1245469011682 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1245469011683 Ligand binding site; other site 1245469011684 Putative Catalytic site; other site 1245469011685 DXD motif; other site 1245469011686 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1245469011687 active site 1245469011688 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1245469011689 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1245469011690 Transglycosylase; Region: Transgly; pfam00912 1245469011691 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1245469011692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1245469011693 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1245469011694 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1245469011695 MG2 domain; Region: A2M_N; pfam01835 1245469011696 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1245469011697 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1245469011698 surface patch; other site 1245469011699 thioester region; other site 1245469011700 specificity defining residues; other site 1245469011701 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1245469011702 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469011703 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1245469011704 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1245469011705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469011706 putative substrate translocation pore; other site 1245469011707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469011708 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1245469011709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469011710 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469011711 PRC-barrel domain; Region: PRC; pfam05239 1245469011712 oxidoreductase; Provisional; Region: PRK07985 1245469011713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469011714 NAD(P) binding site [chemical binding]; other site 1245469011715 active site 1245469011716 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469011717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011718 dimerization interface [polypeptide binding]; other site 1245469011719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011720 dimerization interface [polypeptide binding]; other site 1245469011721 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469011722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011723 dimerization interface [polypeptide binding]; other site 1245469011724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011725 dimerization interface [polypeptide binding]; other site 1245469011726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011727 dimerization interface [polypeptide binding]; other site 1245469011728 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469011729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011730 dimerization interface [polypeptide binding]; other site 1245469011731 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011732 dimerization interface [polypeptide binding]; other site 1245469011733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011734 dimerization interface [polypeptide binding]; other site 1245469011735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011736 dimerization interface [polypeptide binding]; other site 1245469011737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011738 dimerization interface [polypeptide binding]; other site 1245469011739 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469011740 dimerization interface [polypeptide binding]; other site 1245469011741 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469011742 GAF domain; Region: GAF; pfam01590 1245469011743 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469011744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469011745 dimer interface [polypeptide binding]; other site 1245469011746 phosphorylation site [posttranslational modification] 1245469011747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469011748 ATP binding site [chemical binding]; other site 1245469011749 Mg2+ binding site [ion binding]; other site 1245469011750 G-X-G motif; other site 1245469011751 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469011752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011753 active site 1245469011754 phosphorylation site [posttranslational modification] 1245469011755 intermolecular recognition site; other site 1245469011756 dimerization interface [polypeptide binding]; other site 1245469011757 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469011758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011759 active site 1245469011760 phosphorylation site [posttranslational modification] 1245469011761 intermolecular recognition site; other site 1245469011762 dimerization interface [polypeptide binding]; other site 1245469011763 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469011764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011765 active site 1245469011766 phosphorylation site [posttranslational modification] 1245469011767 intermolecular recognition site; other site 1245469011768 dimerization interface [polypeptide binding]; other site 1245469011769 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469011770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011771 active site 1245469011772 phosphorylation site [posttranslational modification] 1245469011773 intermolecular recognition site; other site 1245469011774 dimerization interface [polypeptide binding]; other site 1245469011775 PAS fold; Region: PAS_3; pfam08447 1245469011776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469011777 putative active site [active] 1245469011778 heme pocket [chemical binding]; other site 1245469011779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469011780 HWE histidine kinase; Region: HWE_HK; smart00911 1245469011781 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1245469011782 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1245469011783 putative molybdopterin cofactor binding site [chemical binding]; other site 1245469011784 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1245469011785 putative molybdopterin cofactor binding site; other site 1245469011786 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1245469011787 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1245469011788 proposed catalytic triad [active] 1245469011789 conserved cys residue [active] 1245469011790 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 1245469011791 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1245469011792 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1245469011793 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1245469011794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469011795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469011796 active site 1245469011797 phosphorylation site [posttranslational modification] 1245469011798 intermolecular recognition site; other site 1245469011799 dimerization interface [polypeptide binding]; other site 1245469011800 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469011801 DNA binding site [nucleotide binding] 1245469011802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469011803 HAMP domain; Region: HAMP; pfam00672 1245469011804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469011805 dimer interface [polypeptide binding]; other site 1245469011806 phosphorylation site [posttranslational modification] 1245469011807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469011808 ATP binding site [chemical binding]; other site 1245469011809 Mg2+ binding site [ion binding]; other site 1245469011810 G-X-G motif; other site 1245469011811 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469011812 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1245469011813 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469011814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469011815 dimer interface [polypeptide binding]; other site 1245469011816 conserved gate region; other site 1245469011817 putative PBP binding loops; other site 1245469011818 ABC-ATPase subunit interface; other site 1245469011819 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469011820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469011821 dimer interface [polypeptide binding]; other site 1245469011822 conserved gate region; other site 1245469011823 putative PBP binding loops; other site 1245469011824 ABC-ATPase subunit interface; other site 1245469011825 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469011826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469011827 Walker A/P-loop; other site 1245469011828 ATP binding site [chemical binding]; other site 1245469011829 Q-loop/lid; other site 1245469011830 ABC transporter signature motif; other site 1245469011831 Walker B; other site 1245469011832 D-loop; other site 1245469011833 H-loop/switch region; other site 1245469011834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469011835 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469011836 Walker A/P-loop; other site 1245469011837 ATP binding site [chemical binding]; other site 1245469011838 Q-loop/lid; other site 1245469011839 ABC transporter signature motif; other site 1245469011840 Walker B; other site 1245469011841 D-loop; other site 1245469011842 H-loop/switch region; other site 1245469011843 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469011844 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1245469011845 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469011846 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1245469011847 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1245469011848 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469011849 catalytic loop [active] 1245469011850 iron binding site [ion binding]; other site 1245469011851 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1245469011852 FAD binding pocket [chemical binding]; other site 1245469011853 FAD binding motif [chemical binding]; other site 1245469011854 phosphate binding motif [ion binding]; other site 1245469011855 beta-alpha-beta structure motif; other site 1245469011856 NAD binding pocket [chemical binding]; other site 1245469011857 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1245469011858 DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625 1245469011859 putative ligand binding site [chemical binding]; other site 1245469011860 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1245469011861 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469011862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469011863 Walker A/P-loop; other site 1245469011864 ATP binding site [chemical binding]; other site 1245469011865 Q-loop/lid; other site 1245469011866 ABC transporter signature motif; other site 1245469011867 Walker B; other site 1245469011868 D-loop; other site 1245469011869 H-loop/switch region; other site 1245469011870 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469011871 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469011872 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469011873 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469011874 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469011875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469011876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011877 TPR motif; other site 1245469011878 binding surface 1245469011879 TPR repeat; Region: TPR_11; pfam13414 1245469011880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011881 binding surface 1245469011882 TPR motif; other site 1245469011883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011884 TPR motif; other site 1245469011885 binding surface 1245469011886 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469011887 TPR repeat; Region: TPR_11; pfam13414 1245469011888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011889 binding surface 1245469011890 TPR motif; other site 1245469011891 TPR repeat; Region: TPR_11; pfam13414 1245469011892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011893 binding surface 1245469011894 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469011895 TPR motif; other site 1245469011896 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1245469011897 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469011898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011899 binding surface 1245469011900 TPR motif; other site 1245469011901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011902 binding surface 1245469011903 TPR motif; other site 1245469011904 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469011905 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469011906 binding surface 1245469011907 TPR motif; other site 1245469011908 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1245469011909 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_2; cd08822 1245469011910 putative active site [active] 1245469011911 putative substrate binding site [chemical binding]; other site 1245469011912 putative cosubstrate binding site; other site 1245469011913 catalytic site [active] 1245469011914 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469011915 EamA-like transporter family; Region: EamA; pfam00892 1245469011916 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 1245469011917 Caspase domain; Region: Peptidase_C14; pfam00656 1245469011918 active site 1245469011919 substrate pocket [chemical binding]; other site 1245469011920 proteolytic cleavage site; other site 1245469011921 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469011922 Caspase domain; Region: Peptidase_C14; pfam00656 1245469011923 active site 1245469011924 substrate pocket [chemical binding]; other site 1245469011925 proteolytic cleavage site; other site 1245469011926 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469011927 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 1245469011928 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1245469011929 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1245469011930 dimer interface [polypeptide binding]; other site 1245469011931 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469011932 catalytic residue [active] 1245469011933 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1245469011934 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1245469011935 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1245469011936 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1245469011937 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1245469011938 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1245469011939 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1245469011940 active site 1245469011941 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1245469011942 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1245469011943 active site 1245469011944 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1245469011945 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1245469011946 active site 1245469011947 (T/H)XGH motif; other site 1245469011948 DNA gyrase subunit A; Validated; Region: PRK05560 1245469011949 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1245469011950 CAP-like domain; other site 1245469011951 active site 1245469011952 primary dimer interface [polypeptide binding]; other site 1245469011953 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1245469011954 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1245469011955 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1245469011956 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1245469011957 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1245469011958 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 1245469011959 HD domain; Region: HD_3; pfam13023 1245469011960 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1245469011961 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1245469011962 dimer interface [polypeptide binding]; other site 1245469011963 ssDNA binding site [nucleotide binding]; other site 1245469011964 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1245469011965 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469011966 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469011967 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1245469011968 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469011969 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1245469011970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1245469011971 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1245469011972 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1245469011973 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1245469011974 active site flap/lid [active] 1245469011975 nucleophilic elbow; other site 1245469011976 catalytic triad [active] 1245469011977 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1245469011978 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1245469011979 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469011980 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469011981 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469011982 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469011983 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469011984 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469011985 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1245469011986 putative hydrophobic ligand binding site [chemical binding]; other site 1245469011987 protein interface [polypeptide binding]; other site 1245469011988 gate; other site 1245469011989 hypothetical protein; Provisional; Region: PRK10396 1245469011990 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 1245469011991 SEC-C motif; Region: SEC-C; pfam02810 1245469011992 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469011993 dimer interface [polypeptide binding]; other site 1245469011994 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469011995 putative CheW interface [polypeptide binding]; other site 1245469011996 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469011997 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469011998 catalytic residue [active] 1245469011999 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469012000 Cytochrome P450; Region: p450; cl12078 1245469012001 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 1245469012002 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1245469012003 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1245469012004 PhnA protein; Region: PhnA; pfam03831 1245469012005 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1245469012006 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1245469012007 putative metal binding site [ion binding]; other site 1245469012008 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1245469012009 active site 1245469012010 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1245469012011 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1245469012012 iron-sulfur cluster [ion binding]; other site 1245469012013 [2Fe-2S] cluster binding site [ion binding]; other site 1245469012014 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 1245469012015 Bacterial SH3 domain; Region: SH3_3; pfam08239 1245469012016 Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839 1245469012017 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1245469012018 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1245469012019 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469012020 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469012021 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469012022 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469012023 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469012024 putative effector binding pocket; other site 1245469012025 dimerization interface [polypeptide binding]; other site 1245469012026 benzoate transport; Region: 2A0115; TIGR00895 1245469012027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469012028 putative substrate translocation pore; other site 1245469012029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469012030 putative substrate translocation pore; other site 1245469012031 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1245469012032 Amidohydrolase; Region: Amidohydro_2; pfam04909 1245469012033 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1245469012034 iron-sulfur cluster [ion binding]; other site 1245469012035 [2Fe-2S] cluster binding site [ion binding]; other site 1245469012036 Predicted membrane protein [Function unknown]; Region: COG4244 1245469012037 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1245469012038 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1245469012039 Protein of unknown function DUF72; Region: DUF72; pfam01904 1245469012040 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1245469012041 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469012042 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469012043 ligand binding site [chemical binding]; other site 1245469012044 flexible hinge region; other site 1245469012045 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469012046 putative switch regulator; other site 1245469012047 non-specific DNA interactions [nucleotide binding]; other site 1245469012048 DNA binding site [nucleotide binding] 1245469012049 sequence specific DNA binding site [nucleotide binding]; other site 1245469012050 putative cAMP binding site [chemical binding]; other site 1245469012051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469012052 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469012053 putative active site [active] 1245469012054 heme pocket [chemical binding]; other site 1245469012055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469012056 putative active site [active] 1245469012057 heme pocket [chemical binding]; other site 1245469012058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469012059 HWE histidine kinase; Region: HWE_HK; smart00911 1245469012060 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1245469012061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469012062 motif II; other site 1245469012063 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469012064 Zn2+ binding site [ion binding]; other site 1245469012065 Mg2+ binding site [ion binding]; other site 1245469012066 TIGR02680 family protein; Region: TIGR02680 1245469012067 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1245469012068 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1245469012069 putative ligand binding site [chemical binding]; other site 1245469012070 NAD binding site [chemical binding]; other site 1245469012071 dimerization interface [polypeptide binding]; other site 1245469012072 catalytic site [active] 1245469012073 acetylornithine deacetylase; Provisional; Region: PRK06837 1245469012074 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1245469012075 metal binding site [ion binding]; metal-binding site 1245469012076 dimer interface [polypeptide binding]; other site 1245469012077 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 1245469012078 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469012079 inhibitor-cofactor binding pocket; inhibition site 1245469012080 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469012081 catalytic residue [active] 1245469012082 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1245469012083 FIST N domain; Region: FIST; pfam08495 1245469012084 FIST C domain; Region: FIST_C; pfam10442 1245469012085 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469012086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469012087 dimer interface [polypeptide binding]; other site 1245469012088 putative CheW interface [polypeptide binding]; other site 1245469012089 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1245469012090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469012091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469012092 dimerization interface [polypeptide binding]; other site 1245469012093 Predicted flavoprotein [General function prediction only]; Region: COG0431 1245469012094 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1245469012095 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469012096 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469012097 active site 1245469012098 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469012099 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469012100 Walker A/P-loop; other site 1245469012101 ATP binding site [chemical binding]; other site 1245469012102 Q-loop/lid; other site 1245469012103 ABC transporter signature motif; other site 1245469012104 Walker B; other site 1245469012105 D-loop; other site 1245469012106 H-loop/switch region; other site 1245469012107 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 1245469012108 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469012109 putative ligand binding site [chemical binding]; other site 1245469012110 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469012111 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469012112 TM-ABC transporter signature motif; other site 1245469012113 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469012114 TM-ABC transporter signature motif; other site 1245469012115 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469012116 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469012117 Walker A/P-loop; other site 1245469012118 ATP binding site [chemical binding]; other site 1245469012119 Q-loop/lid; other site 1245469012120 ABC transporter signature motif; other site 1245469012121 Walker B; other site 1245469012122 D-loop; other site 1245469012123 H-loop/switch region; other site 1245469012124 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1245469012125 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1245469012126 active site 1245469012127 dimer interface [polypeptide binding]; other site 1245469012128 non-prolyl cis peptide bond; other site 1245469012129 insertion regions; other site 1245469012130 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1245469012131 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1245469012132 PAS fold; Region: PAS_4; pfam08448 1245469012133 PAS fold; Region: PAS_4; pfam08448 1245469012134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469012135 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469012136 dimer interface [polypeptide binding]; other site 1245469012137 phosphorylation site [posttranslational modification] 1245469012138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469012139 ATP binding site [chemical binding]; other site 1245469012140 Mg2+ binding site [ion binding]; other site 1245469012141 G-X-G motif; other site 1245469012142 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469012143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469012144 active site 1245469012145 phosphorylation site [posttranslational modification] 1245469012146 intermolecular recognition site; other site 1245469012147 dimerization interface [polypeptide binding]; other site 1245469012148 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1245469012149 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469012150 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469012151 ABC transporter; Region: ABC_tran_2; pfam12848 1245469012152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469012153 glutamine synthetase; Region: PLN02284 1245469012154 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1245469012155 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1245469012156 Protein of unknown function (DUF2735); Region: DUF2735; pfam10931 1245469012157 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1245469012158 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1245469012159 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1245469012160 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1245469012161 active site 1245469012162 catalytic triad [active] 1245469012163 oxyanion hole [active] 1245469012164 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469012165 dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334 1245469012166 NAD binding site [chemical binding]; other site 1245469012167 homodimer interface [polypeptide binding]; other site 1245469012168 active site 1245469012169 Uncharacterized conserved protein [Function unknown]; Region: COG5482 1245469012170 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469012171 Coenzyme A binding pocket [chemical binding]; other site 1245469012172 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469012173 CoenzymeA binding site [chemical binding]; other site 1245469012174 subunit interaction site [polypeptide binding]; other site 1245469012175 PHB binding site; other site 1245469012176 acetylornithine deacetylase; Provisional; Region: PRK06837 1245469012177 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1245469012178 metal binding site [ion binding]; metal-binding site 1245469012179 dimer interface [polypeptide binding]; other site 1245469012180 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469012181 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469012182 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469012183 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469012184 catalytic loop [active] 1245469012185 iron binding site [ion binding]; other site 1245469012186 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469012187 cyclase homology domain; Region: CHD; cd07302 1245469012188 dimer interface [polypeptide binding]; other site 1245469012189 nucleotidyl binding site; other site 1245469012190 metal binding site [ion binding]; metal-binding site 1245469012191 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1245469012192 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469012193 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1245469012194 Walker A/P-loop; other site 1245469012195 ATP binding site [chemical binding]; other site 1245469012196 Q-loop/lid; other site 1245469012197 ABC transporter signature motif; other site 1245469012198 Walker B; other site 1245469012199 D-loop; other site 1245469012200 H-loop/switch region; other site 1245469012201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 1245469012202 CreA protein; Region: CreA; pfam05981 1245469012203 hypothetical protein; Provisional; Region: PRK06132 1245469012204 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469012205 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1245469012206 catalytic residues [active] 1245469012207 dimer interface [polypeptide binding]; other site 1245469012208 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1245469012209 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1245469012210 NodB motif; other site 1245469012211 active site 1245469012212 catalytic site [active] 1245469012213 metal binding site [ion binding]; metal-binding site 1245469012214 Predicted membrane protein [Function unknown]; Region: COG2259 1245469012215 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1245469012216 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1245469012217 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1245469012218 putative NAD(P) binding site [chemical binding]; other site 1245469012219 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1245469012220 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1245469012221 TadE-like protein; Region: TadE; pfam07811 1245469012222 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1245469012223 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1245469012224 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469012225 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469012226 putative ligand binding site [chemical binding]; other site 1245469012227 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1245469012228 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1245469012229 dimer interface [polypeptide binding]; other site 1245469012230 anticodon binding site; other site 1245469012231 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1245469012232 homodimer interface [polypeptide binding]; other site 1245469012233 motif 1; other site 1245469012234 active site 1245469012235 motif 2; other site 1245469012236 GAD domain; Region: GAD; pfam02938 1245469012237 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1245469012238 active site 1245469012239 motif 3; other site 1245469012240 hypothetical protein; Validated; Region: PRK00029 1245469012241 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1245469012242 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1245469012243 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1245469012244 catalytic site [active] 1245469012245 putative active site [active] 1245469012246 putative substrate binding site [chemical binding]; other site 1245469012247 HRDC domain; Region: HRDC; pfam00570 1245469012248 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469012249 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1245469012250 catalytic triad [active] 1245469012251 conserved cis-peptide bond; other site 1245469012252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469012253 Coenzyme A binding pocket [chemical binding]; other site 1245469012254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469012255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469012256 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1245469012257 dimerization interface [polypeptide binding]; other site 1245469012258 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1245469012259 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469012260 DNA-binding site [nucleotide binding]; DNA binding site 1245469012261 RNA-binding motif; other site 1245469012262 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1245469012263 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1245469012264 active site 1245469012265 substrate binding site [chemical binding]; other site 1245469012266 cosubstrate binding site; other site 1245469012267 catalytic site [active] 1245469012268 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1245469012269 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1245469012270 dimerization interface [polypeptide binding]; other site 1245469012271 putative ATP binding site [chemical binding]; other site 1245469012272 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1245469012273 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1245469012274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469012275 polyphosphate kinase; Provisional; Region: PRK05443 1245469012276 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1245469012277 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1245469012278 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1245469012279 putative domain interface [polypeptide binding]; other site 1245469012280 putative active site [active] 1245469012281 catalytic site [active] 1245469012282 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1245469012283 putative domain interface [polypeptide binding]; other site 1245469012284 putative active site [active] 1245469012285 catalytic site [active] 1245469012286 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1245469012287 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1245469012288 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469012289 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 1245469012290 NAD(P) binding site [chemical binding]; other site 1245469012291 catalytic residues [active] 1245469012292 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1245469012293 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1245469012294 putative nucleotide binding site [chemical binding]; other site 1245469012295 putative substrate binding site [chemical binding]; other site 1245469012296 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1245469012297 nucleotide binding site [chemical binding]; other site 1245469012298 substrate binding site [chemical binding]; other site 1245469012299 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469012300 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 1245469012301 NAD(P) binding site [chemical binding]; other site 1245469012302 catalytic residues [active] 1245469012303 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1245469012304 PBP superfamily domain; Region: PBP_like; pfam12727 1245469012305 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1245469012306 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1245469012307 active site 1245469012308 multimer interface [polypeptide binding]; other site 1245469012309 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1245469012310 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469012311 Walker A/P-loop; other site 1245469012312 ATP binding site [chemical binding]; other site 1245469012313 Q-loop/lid; other site 1245469012314 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469012315 ABC transporter; Region: ABC_tran_2; pfam12848 1245469012316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469012317 DNA polymerase III subunit chi; Validated; Region: PRK05728 1245469012318 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1245469012319 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1245469012320 interface (dimer of trimers) [polypeptide binding]; other site 1245469012321 Substrate-binding/catalytic site; other site 1245469012322 Zn-binding sites [ion binding]; other site 1245469012323 Predicted permeases [General function prediction only]; Region: COG0795 1245469012324 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1245469012325 Predicted permeases [General function prediction only]; Region: COG0795 1245469012326 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1245469012327 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1245469012328 OstA-like protein; Region: OstA; cl00844 1245469012329 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1245469012330 SurA N-terminal domain; Region: SurA_N_3; cl07813 1245469012331 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 1245469012332 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1245469012333 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1245469012334 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1245469012335 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1245469012336 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 1245469012337 putative NAD(P) binding site [chemical binding]; other site 1245469012338 catalytic Zn binding site [ion binding]; other site 1245469012339 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1245469012340 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1245469012341 catalytic site [active] 1245469012342 G-X2-G-X-G-K; other site 1245469012343 hypothetical protein; Provisional; Region: PRK11820 1245469012344 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1245469012345 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1245469012346 YceG-like family; Region: YceG; pfam02618 1245469012347 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1245469012348 dimerization interface [polypeptide binding]; other site 1245469012349 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1245469012350 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1245469012351 dimer interface [polypeptide binding]; other site 1245469012352 active site 1245469012353 acyl carrier protein; Provisional; Region: acpP; PRK00982 1245469012354 3-ketoacyl-(acyl-carrier-protein) reductase NodG; Reviewed; Region: PRK12936 1245469012355 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1245469012356 NAD(P) binding site [chemical binding]; other site 1245469012357 homotetramer interface [polypeptide binding]; other site 1245469012358 homodimer interface [polypeptide binding]; other site 1245469012359 active site 1245469012360 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1245469012361 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1245469012362 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1245469012363 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1245469012364 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1245469012365 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1245469012366 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1245469012367 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1245469012368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469012369 S-adenosylmethionine binding site [chemical binding]; other site 1245469012370 replicative DNA helicase; Provisional; Region: PRK09165 1245469012371 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1245469012372 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1245469012373 Walker A motif; other site 1245469012374 ATP binding site [chemical binding]; other site 1245469012375 Walker B motif; other site 1245469012376 DNA binding loops [nucleotide binding] 1245469012377 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1245469012378 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1245469012379 active site 1245469012380 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469012381 dimer interface [polypeptide binding]; other site 1245469012382 substrate binding site [chemical binding]; other site 1245469012383 catalytic residues [active] 1245469012384 Cysteine rich repeat; Region: Cys_rich_FGFR; pfam00839 1245469012385 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1245469012386 putative catalytic site [active] 1245469012387 putative phosphate binding site [ion binding]; other site 1245469012388 active site 1245469012389 metal binding site A [ion binding]; metal-binding site 1245469012390 DNA binding site [nucleotide binding] 1245469012391 putative AP binding site [nucleotide binding]; other site 1245469012392 putative metal binding site B [ion binding]; other site 1245469012393 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1245469012394 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469012395 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469012396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469012397 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469012398 DNA repair protein RadA; Provisional; Region: PRK11823 1245469012399 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1245469012400 Walker A motif/ATP binding site; other site 1245469012401 ATP binding site [chemical binding]; other site 1245469012402 Walker B motif; other site 1245469012403 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1245469012404 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1245469012405 Colicin V production protein; Region: Colicin_V; pfam02674 1245469012406 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1245469012407 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1245469012408 active site 1245469012409 tetramer interface [polypeptide binding]; other site 1245469012410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469012411 active site 1245469012412 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1245469012413 classical (c) SDRs; Region: SDR_c; cd05233 1245469012414 NAD(P) binding site [chemical binding]; other site 1245469012415 active site 1245469012416 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1245469012417 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1245469012418 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1245469012419 active site 1245469012420 nucleophile elbow; other site 1245469012421 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1245469012422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469012423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469012424 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1245469012425 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1245469012426 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469012427 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469012428 putative ligand binding site [chemical binding]; other site 1245469012429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469012430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469012431 putative substrate translocation pore; other site 1245469012432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469012433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469012434 DNA binding residues [nucleotide binding] 1245469012435 dimerization interface [polypeptide binding]; other site 1245469012436 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1245469012437 active site 1245469012438 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1245469012439 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1245469012440 active site 1245469012441 ATP binding site [chemical binding]; other site 1245469012442 substrate binding site [chemical binding]; other site 1245469012443 activation loop (A-loop); other site 1245469012444 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1245469012445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469012446 putative substrate translocation pore; other site 1245469012447 GTP-binding protein Der; Reviewed; Region: PRK00093 1245469012448 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1245469012449 G1 box; other site 1245469012450 GTP/Mg2+ binding site [chemical binding]; other site 1245469012451 Switch I region; other site 1245469012452 G2 box; other site 1245469012453 Switch II region; other site 1245469012454 G3 box; other site 1245469012455 G4 box; other site 1245469012456 G5 box; other site 1245469012457 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1245469012458 G1 box; other site 1245469012459 GTP/Mg2+ binding site [chemical binding]; other site 1245469012460 Switch I region; other site 1245469012461 G2 box; other site 1245469012462 G3 box; other site 1245469012463 Switch II region; other site 1245469012464 G4 box; other site 1245469012465 G5 box; other site 1245469012466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 1245469012467 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 1245469012468 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1245469012469 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469012470 acyl-activating enzyme (AAE) consensus motif; other site 1245469012471 AMP binding site [chemical binding]; other site 1245469012472 active site 1245469012473 CoA binding site [chemical binding]; other site 1245469012474 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1245469012475 oligomerization interface [polypeptide binding]; other site 1245469012476 active site 1245469012477 metal binding site [ion binding]; metal-binding site 1245469012478 NnrU protein; Region: NnrU; pfam07298 1245469012479 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1245469012480 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1245469012481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469012482 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469012483 protein binding site [polypeptide binding]; other site 1245469012484 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469012485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469012486 DNA binding residues [nucleotide binding] 1245469012487 dimerization interface [polypeptide binding]; other site 1245469012488 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1245469012489 active site 1245469012490 oxyanion hole [active] 1245469012491 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 1245469012492 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1245469012493 G1 box; other site 1245469012494 putative GEF interaction site [polypeptide binding]; other site 1245469012495 GTP/Mg2+ binding site [chemical binding]; other site 1245469012496 Switch I region; other site 1245469012497 G2 box; other site 1245469012498 G3 box; other site 1245469012499 Switch II region; other site 1245469012500 G4 box; other site 1245469012501 G5 box; other site 1245469012502 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1245469012503 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1245469012504 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1245469012505 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469012506 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469012507 TM-ABC transporter signature motif; other site 1245469012508 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469012509 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469012510 TM-ABC transporter signature motif; other site 1245469012511 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469012512 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469012513 putative ligand binding site [chemical binding]; other site 1245469012514 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469012515 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469012516 Walker A/P-loop; other site 1245469012517 ATP binding site [chemical binding]; other site 1245469012518 Q-loop/lid; other site 1245469012519 ABC transporter signature motif; other site 1245469012520 Walker B; other site 1245469012521 D-loop; other site 1245469012522 H-loop/switch region; other site 1245469012523 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469012524 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469012525 Walker A/P-loop; other site 1245469012526 ATP binding site [chemical binding]; other site 1245469012527 Q-loop/lid; other site 1245469012528 ABC transporter signature motif; other site 1245469012529 Walker B; other site 1245469012530 D-loop; other site 1245469012531 H-loop/switch region; other site 1245469012532 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1245469012533 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469012534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1245469012535 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1245469012536 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1245469012537 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1245469012538 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1245469012539 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1245469012540 FAD binding domain; Region: FAD_binding_3; pfam01494 1245469012541 hypothetical protein; Provisional; Region: PRK07236 1245469012542 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469012543 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1245469012544 ArsC family; Region: ArsC; pfam03960 1245469012545 putative catalytic residues [active] 1245469012546 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1245469012547 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1245469012548 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469012549 ATP binding site [chemical binding]; other site 1245469012550 putative Mg++ binding site [ion binding]; other site 1245469012551 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469012552 nucleotide binding region [chemical binding]; other site 1245469012553 ATP-binding site [chemical binding]; other site 1245469012554 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 1245469012555 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1245469012556 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469012557 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1245469012558 C-terminal domain interface [polypeptide binding]; other site 1245469012559 GSH binding site (G-site) [chemical binding]; other site 1245469012560 dimer interface [polypeptide binding]; other site 1245469012561 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 1245469012562 dimer interface [polypeptide binding]; other site 1245469012563 N-terminal domain interface [polypeptide binding]; other site 1245469012564 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1245469012565 TROVE domain; Region: TROVE; pfam05731 1245469012566 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1245469012567 metal ion-dependent adhesion site (MIDAS); other site 1245469012568 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1245469012569 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1245469012570 active site 1245469012571 catalytic site [active] 1245469012572 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1245469012573 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 1245469012574 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1245469012575 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1245469012576 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1245469012577 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1245469012578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012579 dimer interface [polypeptide binding]; other site 1245469012580 conserved gate region; other site 1245469012581 putative PBP binding loops; other site 1245469012582 ABC-ATPase subunit interface; other site 1245469012583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469012584 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469012585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469012586 Walker A/P-loop; other site 1245469012587 ATP binding site [chemical binding]; other site 1245469012588 Q-loop/lid; other site 1245469012589 ABC transporter signature motif; other site 1245469012590 Walker B; other site 1245469012591 D-loop; other site 1245469012592 H-loop/switch region; other site 1245469012593 TOBE domain; Region: TOBE_2; pfam08402 1245469012594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469012595 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469012596 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1245469012597 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1245469012598 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 1245469012599 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469012600 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469012601 Walker A/P-loop; other site 1245469012602 ATP binding site [chemical binding]; other site 1245469012603 Q-loop/lid; other site 1245469012604 ABC transporter signature motif; other site 1245469012605 Walker B; other site 1245469012606 D-loop; other site 1245469012607 H-loop/switch region; other site 1245469012608 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469012609 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469012610 Walker A/P-loop; other site 1245469012611 ATP binding site [chemical binding]; other site 1245469012612 Q-loop/lid; other site 1245469012613 ABC transporter signature motif; other site 1245469012614 Walker B; other site 1245469012615 D-loop; other site 1245469012616 H-loop/switch region; other site 1245469012617 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469012618 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469012619 TM-ABC transporter signature motif; other site 1245469012620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469012621 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469012622 TM-ABC transporter signature motif; other site 1245469012623 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469012624 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469012625 putative ligand binding site [chemical binding]; other site 1245469012626 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469012627 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469012628 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469012629 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 1245469012630 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469012631 catalytic loop [active] 1245469012632 iron binding site [ion binding]; other site 1245469012633 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469012634 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1245469012635 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1245469012636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469012637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469012638 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1245469012639 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1245469012640 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1245469012641 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1245469012642 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1245469012643 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1245469012644 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1245469012645 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1245469012646 Phage protein D [General function prediction only]; Region: COG3500 1245469012647 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1245469012648 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 1245469012649 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1245469012650 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1245469012651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469012652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469012653 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1245469012654 Walker A motif; other site 1245469012655 ATP binding site [chemical binding]; other site 1245469012656 Walker B motif; other site 1245469012657 arginine finger; other site 1245469012658 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1245469012659 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1245469012660 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469012661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469012662 binding surface 1245469012663 TPR motif; other site 1245469012664 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469012665 binding surface 1245469012666 TPR repeat; Region: TPR_11; pfam13414 1245469012667 TPR motif; other site 1245469012668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469012669 binding surface 1245469012670 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469012671 TPR motif; other site 1245469012672 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469012673 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1245469012674 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1245469012675 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1245469012676 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1245469012677 thioredoxin 2; Provisional; Region: PRK10996 1245469012678 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1245469012679 catalytic residues [active] 1245469012680 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1245469012681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469012682 dimerization interface [polypeptide binding]; other site 1245469012683 putative DNA binding site [nucleotide binding]; other site 1245469012684 putative Zn2+ binding site [ion binding]; other site 1245469012685 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469012686 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469012687 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469012688 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1245469012689 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1245469012690 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1245469012691 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469012692 metal binding site [ion binding]; metal-binding site 1245469012693 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469012694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469012695 Walker A/P-loop; other site 1245469012696 ATP binding site [chemical binding]; other site 1245469012697 Q-loop/lid; other site 1245469012698 ABC transporter signature motif; other site 1245469012699 Walker B; other site 1245469012700 D-loop; other site 1245469012701 H-loop/switch region; other site 1245469012702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469012703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469012704 Walker A/P-loop; other site 1245469012705 ATP binding site [chemical binding]; other site 1245469012706 Q-loop/lid; other site 1245469012707 ABC transporter signature motif; other site 1245469012708 Walker B; other site 1245469012709 D-loop; other site 1245469012710 H-loop/switch region; other site 1245469012711 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469012712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012713 dimer interface [polypeptide binding]; other site 1245469012714 conserved gate region; other site 1245469012715 putative PBP binding loops; other site 1245469012716 ABC-ATPase subunit interface; other site 1245469012717 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469012718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012719 dimer interface [polypeptide binding]; other site 1245469012720 conserved gate region; other site 1245469012721 putative PBP binding loops; other site 1245469012722 ABC-ATPase subunit interface; other site 1245469012723 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469012724 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1245469012725 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1245469012726 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469012727 metal binding site [ion binding]; metal-binding site 1245469012728 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469012729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469012730 DNA-binding site [nucleotide binding]; DNA binding site 1245469012731 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1245469012732 UTRA domain; Region: UTRA; pfam07702 1245469012733 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1245469012734 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1245469012735 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1245469012736 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1245469012737 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1245469012738 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1245469012739 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1245469012740 dimerization domain swap beta strand [polypeptide binding]; other site 1245469012741 regulatory protein interface [polypeptide binding]; other site 1245469012742 active site 1245469012743 regulatory phosphorylation site [posttranslational modification]; other site 1245469012744 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 1245469012745 active pocket/dimerization site; other site 1245469012746 active site 1245469012747 phosphorylation site [posttranslational modification] 1245469012748 DAK2 domain; Region: Dak2; cl03685 1245469012749 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469012750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469012751 Walker A/P-loop; other site 1245469012752 ATP binding site [chemical binding]; other site 1245469012753 Q-loop/lid; other site 1245469012754 ABC transporter signature motif; other site 1245469012755 Walker B; other site 1245469012756 D-loop; other site 1245469012757 H-loop/switch region; other site 1245469012758 TOBE domain; Region: TOBE_2; pfam08402 1245469012759 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469012760 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1245469012761 Walker A/P-loop; other site 1245469012762 ATP binding site [chemical binding]; other site 1245469012763 Q-loop/lid; other site 1245469012764 ABC transporter signature motif; other site 1245469012765 Walker B; other site 1245469012766 D-loop; other site 1245469012767 H-loop/switch region; other site 1245469012768 TOBE domain; Region: TOBE_2; pfam08402 1245469012769 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469012770 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012771 dimer interface [polypeptide binding]; other site 1245469012772 conserved gate region; other site 1245469012773 putative PBP binding loops; other site 1245469012774 ABC-ATPase subunit interface; other site 1245469012775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469012776 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1245469012777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012778 dimer interface [polypeptide binding]; other site 1245469012779 conserved gate region; other site 1245469012780 putative PBP binding loops; other site 1245469012781 ABC-ATPase subunit interface; other site 1245469012782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469012783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469012784 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469012785 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1245469012786 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 1245469012787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469012788 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1245469012789 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469012790 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1245469012791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469012792 NAD(P) binding site [chemical binding]; other site 1245469012793 active site 1245469012794 peptidase T-like protein; Region: PepT-like; TIGR01883 1245469012795 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469012796 metal binding site [ion binding]; metal-binding site 1245469012797 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 1245469012798 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469012799 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 1245469012800 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1245469012801 nucleoside/Zn binding site; other site 1245469012802 dimer interface [polypeptide binding]; other site 1245469012803 catalytic motif [active] 1245469012804 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1245469012805 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1245469012806 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1245469012807 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1245469012808 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1245469012809 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1245469012810 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1245469012811 homotrimer interaction site [polypeptide binding]; other site 1245469012812 putative active site [active] 1245469012813 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1245469012814 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1245469012815 Walker A/P-loop; other site 1245469012816 ATP binding site [chemical binding]; other site 1245469012817 Q-loop/lid; other site 1245469012818 ABC transporter signature motif; other site 1245469012819 Walker B; other site 1245469012820 D-loop; other site 1245469012821 H-loop/switch region; other site 1245469012822 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1245469012823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012824 dimer interface [polypeptide binding]; other site 1245469012825 conserved gate region; other site 1245469012826 putative PBP binding loops; other site 1245469012827 ABC-ATPase subunit interface; other site 1245469012828 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1245469012829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012830 putative PBP binding loops; other site 1245469012831 dimer interface [polypeptide binding]; other site 1245469012832 ABC-ATPase subunit interface; other site 1245469012833 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469012834 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469012835 substrate binding pocket [chemical binding]; other site 1245469012836 membrane-bound complex binding site; other site 1245469012837 hinge residues; other site 1245469012838 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1245469012839 dimer interface [polypeptide binding]; other site 1245469012840 FMN binding site [chemical binding]; other site 1245469012841 NADPH bind site [chemical binding]; other site 1245469012842 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469012843 MarR family; Region: MarR_2; pfam12802 1245469012844 dihydroorotase; Provisional; Region: PRK09237 1245469012845 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469012846 active site 1245469012847 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469012848 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469012849 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469012850 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1245469012851 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469012852 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1245469012853 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469012854 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1245469012855 putative hydrophobic ligand binding site [chemical binding]; other site 1245469012856 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012857 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012858 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012859 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469012860 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012861 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012862 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012863 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012864 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012865 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469012866 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012867 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012868 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012869 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469012870 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1245469012871 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469012872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469012873 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469012874 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1245469012875 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1245469012876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469012877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469012878 Walker A/P-loop; other site 1245469012879 ATP binding site [chemical binding]; other site 1245469012880 Q-loop/lid; other site 1245469012881 ABC transporter signature motif; other site 1245469012882 Walker B; other site 1245469012883 D-loop; other site 1245469012884 H-loop/switch region; other site 1245469012885 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1245469012886 putative switch regulator; other site 1245469012887 non-specific DNA interactions [nucleotide binding]; other site 1245469012888 DNA binding site [nucleotide binding] 1245469012889 sequence specific DNA binding site [nucleotide binding]; other site 1245469012890 putative cAMP binding site [chemical binding]; other site 1245469012891 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469012892 NMT1-like family; Region: NMT1_2; pfam13379 1245469012893 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1245469012894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469012895 DNA-binding site [nucleotide binding]; DNA binding site 1245469012896 UTRA domain; Region: UTRA; pfam07702 1245469012897 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1245469012898 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1245469012899 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469012900 EamA-like transporter family; Region: EamA; pfam00892 1245469012901 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1245469012902 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1245469012903 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1245469012904 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1245469012905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469012906 DNA binding site [nucleotide binding] 1245469012907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469012908 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1245469012909 Walker A/P-loop; other site 1245469012910 ATP binding site [chemical binding]; other site 1245469012911 Q-loop/lid; other site 1245469012912 ABC transporter signature motif; other site 1245469012913 Walker B; other site 1245469012914 D-loop; other site 1245469012915 H-loop/switch region; other site 1245469012916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469012917 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469012918 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469012919 Walker A/P-loop; other site 1245469012920 ATP binding site [chemical binding]; other site 1245469012921 Q-loop/lid; other site 1245469012922 ABC transporter signature motif; other site 1245469012923 Walker B; other site 1245469012924 D-loop; other site 1245469012925 H-loop/switch region; other site 1245469012926 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469012927 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469012928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012929 dimer interface [polypeptide binding]; other site 1245469012930 conserved gate region; other site 1245469012931 putative PBP binding loops; other site 1245469012932 ABC-ATPase subunit interface; other site 1245469012933 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469012934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469012935 dimer interface [polypeptide binding]; other site 1245469012936 conserved gate region; other site 1245469012937 putative PBP binding loops; other site 1245469012938 ABC-ATPase subunit interface; other site 1245469012939 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1245469012940 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469012941 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1245469012942 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1245469012943 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469012944 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469012945 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469012946 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1245469012947 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469012948 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 1245469012949 putative dimerization interface [polypeptide binding]; other site 1245469012950 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469012951 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_1; cd08508 1245469012952 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1245469012953 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469012954 DNA binding residues [nucleotide binding] 1245469012955 dimerization interface [polypeptide binding]; other site 1245469012956 Autoinducer synthetase; Region: Autoind_synth; cl17404 1245469012957 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1245469012958 YcaO-like family; Region: YcaO; pfam02624 1245469012959 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1245469012960 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1245469012961 Acylphosphatase; Region: Acylphosphatase; pfam00708 1245469012962 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1245469012963 HypF finger; Region: zf-HYPF; pfam07503 1245469012964 HypF finger; Region: zf-HYPF; pfam07503 1245469012965 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1245469012966 HupF/HypC family; Region: HupF_HypC; cl00394 1245469012967 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1245469012968 active site 1245469012969 dimer interface [polypeptide binding]; other site 1245469012970 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1245469012971 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1245469012972 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1245469012973 dimerization interface [polypeptide binding]; other site 1245469012974 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1245469012975 ATP binding site [chemical binding]; other site 1245469012976 comF family protein; Region: comF; TIGR00201 1245469012977 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1245469012978 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1245469012979 FAD dependent oxidoreductase; Region: DAO; pfam01266 1245469012980 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1245469012981 active site residue [active] 1245469012982 Sulphur transport; Region: Sulf_transp; pfam04143 1245469012983 putative inner membrane protein; Provisional; Region: PRK11099 1245469012984 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469012985 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1245469012986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469012987 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469012988 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469012989 dimer interface [polypeptide binding]; other site 1245469012990 putative CheW interface [polypeptide binding]; other site 1245469012991 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1245469012992 DsrE/DsrF-like family; Region: DrsE; cl00672 1245469012993 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469012994 DsrE/DsrF-like family; Region: DrsE; pfam02635 1245469012995 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469012996 bacterial SoxC is a member of the sulfite oxidase (SO) family of molybdopterin binding domains. SoxC is involved in oxidation of sulfur compounds during chemolithothrophic growth. Together with SoxD, a small c-type heme containing subunit, it forms a...; Region: bact_SoxC_Moco; cd02113 1245469012997 Moco binding site; other site 1245469012998 metal coordination site [ion binding]; other site 1245469012999 dimerization interface [polypeptide binding]; other site 1245469013000 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1245469013001 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 1245469013002 active site 1245469013003 metal binding site [ion binding]; metal-binding site 1245469013004 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1245469013005 Cytochrome c [Energy production and conversion]; Region: COG3258 1245469013006 Cytochrome c [Energy production and conversion]; Region: COG3258 1245469013007 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1245469013008 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1245469013009 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1245469013010 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469013011 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 1245469013012 catalytic residues [active] 1245469013013 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1245469013014 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1245469013015 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469013016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469013017 dimerization interface [polypeptide binding]; other site 1245469013018 putative DNA binding site [nucleotide binding]; other site 1245469013019 putative Zn2+ binding site [ion binding]; other site 1245469013020 putative inner membrane protein; Provisional; Region: PRK11099 1245469013021 MarR family; Region: MarR_2; cl17246 1245469013022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469013023 salt bridge; other site 1245469013024 sequence-specific DNA binding site [nucleotide binding]; other site 1245469013025 CHAT domain; Region: CHAT; cl17868 1245469013026 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469013027 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469013028 Walker A/P-loop; other site 1245469013029 ATP binding site [chemical binding]; other site 1245469013030 Q-loop/lid; other site 1245469013031 ABC transporter signature motif; other site 1245469013032 Walker B; other site 1245469013033 D-loop; other site 1245469013034 H-loop/switch region; other site 1245469013035 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469013036 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469013037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469013038 Walker A/P-loop; other site 1245469013039 ATP binding site [chemical binding]; other site 1245469013040 Q-loop/lid; other site 1245469013041 ABC transporter signature motif; other site 1245469013042 Walker B; other site 1245469013043 D-loop; other site 1245469013044 H-loop/switch region; other site 1245469013045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469013046 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469013047 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1245469013048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469013049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469013050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013051 dimer interface [polypeptide binding]; other site 1245469013052 conserved gate region; other site 1245469013053 putative PBP binding loops; other site 1245469013054 ABC-ATPase subunit interface; other site 1245469013055 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469013056 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1245469013057 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1245469013058 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1245469013059 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1245469013060 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1245469013061 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1245469013062 active site 1245469013063 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1245469013064 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469013065 DNA-binding site [nucleotide binding]; DNA binding site 1245469013066 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469013067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469013068 homodimer interface [polypeptide binding]; other site 1245469013069 catalytic residue [active] 1245469013070 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469013071 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469013072 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1245469013073 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469013074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469013075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469013076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469013077 dimerization interface [polypeptide binding]; other site 1245469013078 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1245469013079 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1245469013080 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469013081 short chain dehydrogenase; Provisional; Region: PRK07577 1245469013082 classical (c) SDRs; Region: SDR_c; cd05233 1245469013083 NAD(P) binding site [chemical binding]; other site 1245469013084 active site 1245469013085 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469013086 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1245469013087 C-terminal domain interface [polypeptide binding]; other site 1245469013088 GSH binding site (G-site) [chemical binding]; other site 1245469013089 dimer interface [polypeptide binding]; other site 1245469013090 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469013091 N-terminal domain interface [polypeptide binding]; other site 1245469013092 dimer interface [polypeptide binding]; other site 1245469013093 substrate binding pocket (H-site) [chemical binding]; other site 1245469013094 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1245469013095 putative catalytic residues [active] 1245469013096 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469013097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469013098 substrate binding site [chemical binding]; other site 1245469013099 oxyanion hole (OAH) forming residues; other site 1245469013100 trimer interface [polypeptide binding]; other site 1245469013101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469013102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469013103 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469013104 putative effector binding pocket; other site 1245469013105 dimerization interface [polypeptide binding]; other site 1245469013106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469013107 putative substrate translocation pore; other site 1245469013108 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1245469013109 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1245469013110 putative catalytic residues [active] 1245469013111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469013112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469013113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1245469013114 dimerization interface [polypeptide binding]; other site 1245469013115 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1245469013116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469013117 NAD(P) binding site [chemical binding]; other site 1245469013118 active site 1245469013119 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1245469013120 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1245469013121 active site 1245469013122 nucleophile elbow; other site 1245469013123 Patatin phospholipase; Region: DUF3734; pfam12536 1245469013124 Predicted membrane protein [Function unknown]; Region: COG2259 1245469013125 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1245469013126 hypothetical protein; Provisional; Region: PRK05409 1245469013127 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 1245469013128 Cache domain; Region: Cache_1; pfam02743 1245469013129 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469013130 cyclase homology domain; Region: CHD; cd07302 1245469013131 nucleotidyl binding site; other site 1245469013132 metal binding site [ion binding]; metal-binding site 1245469013133 dimer interface [polypeptide binding]; other site 1245469013134 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1245469013135 Protein of unknown function DUF262; Region: DUF262; pfam03235 1245469013136 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1245469013137 GMP synthase; Reviewed; Region: guaA; PRK00074 1245469013138 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1245469013139 AMP/PPi binding site [chemical binding]; other site 1245469013140 candidate oxyanion hole; other site 1245469013141 catalytic triad [active] 1245469013142 potential glutamine specificity residues [chemical binding]; other site 1245469013143 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1245469013144 ATP Binding subdomain [chemical binding]; other site 1245469013145 Ligand Binding sites [chemical binding]; other site 1245469013146 Dimerization subdomain; other site 1245469013147 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1245469013148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469013149 MAPEG family; Region: MAPEG; cl09190 1245469013150 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1245469013151 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1245469013152 NAD(P) binding site [chemical binding]; other site 1245469013153 substrate binding site [chemical binding]; other site 1245469013154 dimer interface [polypeptide binding]; other site 1245469013155 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1245469013156 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1245469013157 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1245469013158 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1245469013159 active site 1245469013160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469013161 putative transporter; Provisional; Region: PRK10504 1245469013162 putative substrate translocation pore; other site 1245469013163 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1245469013164 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1245469013165 DXD motif; other site 1245469013166 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1245469013167 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469013168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1245469013169 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1245469013170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469013171 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 1245469013172 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1245469013173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469013174 S-adenosylmethionine binding site [chemical binding]; other site 1245469013175 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1245469013176 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1245469013177 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469013178 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469013179 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469013180 hypothetical protein; Validated; Region: PRK00124 1245469013181 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1245469013182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469013183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469013184 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1245469013185 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1245469013186 dimer interface [polypeptide binding]; other site 1245469013187 active site 1245469013188 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469013189 substrate binding site [chemical binding]; other site 1245469013190 catalytic residue [active] 1245469013191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469013192 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 1245469013193 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469013194 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1245469013195 NAD binding site [chemical binding]; other site 1245469013196 homodimer interface [polypeptide binding]; other site 1245469013197 active site 1245469013198 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1245469013199 putative active site [active] 1245469013200 putative catalytic site [active] 1245469013201 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1245469013202 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469013203 acyl-activating enzyme (AAE) consensus motif; other site 1245469013204 AMP binding site [chemical binding]; other site 1245469013205 active site 1245469013206 CoA binding site [chemical binding]; other site 1245469013207 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469013208 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1245469013209 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1245469013210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469013211 substrate binding site [chemical binding]; other site 1245469013212 oxyanion hole (OAH) forming residues; other site 1245469013213 trimer interface [polypeptide binding]; other site 1245469013214 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1245469013215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469013216 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 1245469013217 substrate binding pocket [chemical binding]; other site 1245469013218 FAD binding site [chemical binding]; other site 1245469013219 catalytic base [active] 1245469013220 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1245469013221 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1245469013222 tetrameric interface [polypeptide binding]; other site 1245469013223 NAD binding site [chemical binding]; other site 1245469013224 catalytic residues [active] 1245469013225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469013226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469013227 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469013228 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469013229 substrate binding site [chemical binding]; other site 1245469013230 oxyanion hole (OAH) forming residues; other site 1245469013231 trimer interface [polypeptide binding]; other site 1245469013232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469013233 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469013234 putative substrate translocation pore; other site 1245469013235 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1245469013236 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1245469013237 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469013238 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1245469013239 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469013240 glutaminase A; Region: Gln_ase; TIGR03814 1245469013241 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1245469013242 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1245469013243 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469013244 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469013245 ligand binding site [chemical binding]; other site 1245469013246 flexible hinge region; other site 1245469013247 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1245469013248 DUF35 OB-fold domain; Region: DUF35; pfam01796 1245469013249 thiolase; Provisional; Region: PRK06158 1245469013250 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1245469013251 active site 1245469013252 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469013253 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469013254 active site 1245469013255 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469013256 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469013257 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469013258 putative cation:proton antiport protein; Provisional; Region: PRK10669 1245469013259 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1245469013260 TrkA-N domain; Region: TrkA_N; pfam02254 1245469013261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1245469013262 DinB superfamily; Region: DinB_2; pfam12867 1245469013263 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 1245469013264 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1245469013265 active site 1245469013266 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469013267 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 1245469013268 putative NAD(P) binding site [chemical binding]; other site 1245469013269 active site 1245469013270 putative substrate binding site [chemical binding]; other site 1245469013271 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469013272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013273 dimer interface [polypeptide binding]; other site 1245469013274 conserved gate region; other site 1245469013275 putative PBP binding loops; other site 1245469013276 ABC-ATPase subunit interface; other site 1245469013277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013278 dimer interface [polypeptide binding]; other site 1245469013279 conserved gate region; other site 1245469013280 putative PBP binding loops; other site 1245469013281 ABC-ATPase subunit interface; other site 1245469013282 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469013283 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469013284 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1245469013285 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1245469013286 Walker A/P-loop; other site 1245469013287 ATP binding site [chemical binding]; other site 1245469013288 Q-loop/lid; other site 1245469013289 ABC transporter signature motif; other site 1245469013290 Walker B; other site 1245469013291 D-loop; other site 1245469013292 H-loop/switch region; other site 1245469013293 TOBE domain; Region: TOBE_2; pfam08402 1245469013294 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1245469013295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1245469013296 DNA binding site [nucleotide binding] 1245469013297 domain linker motif; other site 1245469013298 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1245469013299 putative dimerization interface [polypeptide binding]; other site 1245469013300 putative ligand binding site [chemical binding]; other site 1245469013301 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 1245469013302 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1245469013303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469013304 NAD(P) binding site [chemical binding]; other site 1245469013305 active site 1245469013306 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469013307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469013308 NAD(P) binding site [chemical binding]; other site 1245469013309 active site 1245469013310 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 1245469013311 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1245469013312 putative ion selectivity filter; other site 1245469013313 putative pore gating glutamate residue; other site 1245469013314 putative H+/Cl- coupling transport residue; other site 1245469013315 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1245469013316 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1245469013317 classical (c) SDRs; Region: SDR_c; cd05233 1245469013318 NAD(P) binding site [chemical binding]; other site 1245469013319 active site 1245469013320 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1245469013321 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1245469013322 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1245469013323 alphaNTD - beta interaction site [polypeptide binding]; other site 1245469013324 alphaNTD homodimer interface [polypeptide binding]; other site 1245469013325 alphaNTD - beta' interaction site [polypeptide binding]; other site 1245469013326 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1245469013327 30S ribosomal protein S11; Validated; Region: PRK05309 1245469013328 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1245469013329 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1245469013330 adenylate kinase; Reviewed; Region: adk; PRK00279 1245469013331 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1245469013332 AMP-binding site [chemical binding]; other site 1245469013333 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1245469013334 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1245469013335 SecY translocase; Region: SecY; pfam00344 1245469013336 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1245469013337 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1245469013338 23S rRNA binding site [nucleotide binding]; other site 1245469013339 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1245469013340 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1245469013341 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1245469013342 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1245469013343 5S rRNA interface [nucleotide binding]; other site 1245469013344 23S rRNA interface [nucleotide binding]; other site 1245469013345 L5 interface [polypeptide binding]; other site 1245469013346 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1245469013347 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1245469013348 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1245469013349 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1245469013350 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1245469013351 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1245469013352 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1245469013353 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1245469013354 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1245469013355 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1245469013356 RNA binding site [nucleotide binding]; other site 1245469013357 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1245469013358 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1245469013359 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1245469013360 23S rRNA interface [nucleotide binding]; other site 1245469013361 putative translocon interaction site; other site 1245469013362 signal recognition particle (SRP54) interaction site; other site 1245469013363 L23 interface [polypeptide binding]; other site 1245469013364 trigger factor interaction site; other site 1245469013365 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1245469013366 23S rRNA interface [nucleotide binding]; other site 1245469013367 5S rRNA interface [nucleotide binding]; other site 1245469013368 putative antibiotic binding site [chemical binding]; other site 1245469013369 L25 interface [polypeptide binding]; other site 1245469013370 L27 interface [polypeptide binding]; other site 1245469013371 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1245469013372 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1245469013373 G-X-X-G motif; other site 1245469013374 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1245469013375 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1245469013376 putative translocon binding site; other site 1245469013377 protein-rRNA interface [nucleotide binding]; other site 1245469013378 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1245469013379 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1245469013380 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1245469013381 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1245469013382 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1245469013383 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1245469013384 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1245469013385 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1245469013386 elongation factor Tu; Reviewed; Region: PRK00049 1245469013387 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1245469013388 G1 box; other site 1245469013389 GEF interaction site [polypeptide binding]; other site 1245469013390 GTP/Mg2+ binding site [chemical binding]; other site 1245469013391 Switch I region; other site 1245469013392 G2 box; other site 1245469013393 G3 box; other site 1245469013394 Switch II region; other site 1245469013395 G4 box; other site 1245469013396 G5 box; other site 1245469013397 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1245469013398 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1245469013399 Antibiotic Binding Site [chemical binding]; other site 1245469013400 elongation factor G; Reviewed; Region: PRK00007 1245469013401 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1245469013402 G1 box; other site 1245469013403 putative GEF interaction site [polypeptide binding]; other site 1245469013404 GTP/Mg2+ binding site [chemical binding]; other site 1245469013405 Switch I region; other site 1245469013406 G2 box; other site 1245469013407 G3 box; other site 1245469013408 Switch II region; other site 1245469013409 G4 box; other site 1245469013410 G5 box; other site 1245469013411 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1245469013412 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1245469013413 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1245469013414 30S ribosomal protein S7; Validated; Region: PRK05302 1245469013415 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1245469013416 S17 interaction site [polypeptide binding]; other site 1245469013417 S8 interaction site; other site 1245469013418 16S rRNA interaction site [nucleotide binding]; other site 1245469013419 streptomycin interaction site [chemical binding]; other site 1245469013420 23S rRNA interaction site [nucleotide binding]; other site 1245469013421 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1245469013422 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1245469013423 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1245469013424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469013425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469013426 Walker A/P-loop; other site 1245469013427 ATP binding site [chemical binding]; other site 1245469013428 Q-loop/lid; other site 1245469013429 ABC transporter signature motif; other site 1245469013430 Walker B; other site 1245469013431 D-loop; other site 1245469013432 H-loop/switch region; other site 1245469013433 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469013434 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1245469013435 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1245469013436 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1245469013437 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1245469013438 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1245469013439 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1245469013440 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1245469013441 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1245469013442 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1245469013443 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1245469013444 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1245469013445 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1245469013446 DNA binding site [nucleotide binding] 1245469013447 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1245469013448 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1245469013449 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1245469013450 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1245469013451 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1245469013452 RPB11 interaction site [polypeptide binding]; other site 1245469013453 RPB12 interaction site [polypeptide binding]; other site 1245469013454 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1245469013455 RPB3 interaction site [polypeptide binding]; other site 1245469013456 RPB1 interaction site [polypeptide binding]; other site 1245469013457 RPB11 interaction site [polypeptide binding]; other site 1245469013458 RPB10 interaction site [polypeptide binding]; other site 1245469013459 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1245469013460 L11 interface [polypeptide binding]; other site 1245469013461 putative EF-Tu interaction site [polypeptide binding]; other site 1245469013462 putative EF-G interaction site [polypeptide binding]; other site 1245469013463 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1245469013464 23S rRNA interface [nucleotide binding]; other site 1245469013465 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1245469013466 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469013467 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469013468 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469013469 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469013470 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469013471 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469013472 catalytic loop [active] 1245469013473 iron binding site [ion binding]; other site 1245469013474 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469013475 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1245469013476 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1245469013477 putative ligand binding site [chemical binding]; other site 1245469013478 NAD binding site [chemical binding]; other site 1245469013479 catalytic site [active] 1245469013480 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1245469013481 mRNA/rRNA interface [nucleotide binding]; other site 1245469013482 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1245469013483 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1245469013484 23S rRNA interface [nucleotide binding]; other site 1245469013485 L7/L12 interface [polypeptide binding]; other site 1245469013486 putative thiostrepton binding site; other site 1245469013487 L25 interface [polypeptide binding]; other site 1245469013488 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1245469013489 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1245469013490 putative homodimer interface [polypeptide binding]; other site 1245469013491 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1245469013492 heterodimer interface [polypeptide binding]; other site 1245469013493 homodimer interface [polypeptide binding]; other site 1245469013494 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1245469013495 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469013496 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469013497 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1245469013498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469013499 NAD(P) binding site [chemical binding]; other site 1245469013500 active site 1245469013501 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1245469013502 catalytic core [active] 1245469013503 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1245469013504 classical (c) SDRs; Region: SDR_c; cd05233 1245469013505 NAD(P) binding site [chemical binding]; other site 1245469013506 active site 1245469013507 NIPSNAP; Region: NIPSNAP; pfam07978 1245469013508 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1245469013509 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469013510 putative active site [active] 1245469013511 putative substrate binding site [chemical binding]; other site 1245469013512 ATP binding site [chemical binding]; other site 1245469013513 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469013514 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469013515 active site 1245469013516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469013517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469013518 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469013519 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469013520 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1245469013521 nudix motif; other site 1245469013522 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1245469013523 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1245469013524 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1245469013525 NADH kinase; Region: PLN02929 1245469013526 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1245469013527 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1245469013528 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1245469013529 catalytic site [active] 1245469013530 active site 1245469013531 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1245469013532 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1245469013533 dimer interface [polypeptide binding]; other site 1245469013534 putative tRNA-binding site [nucleotide binding]; other site 1245469013535 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1245469013536 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469013537 Walker A/P-loop; other site 1245469013538 ATP binding site [chemical binding]; other site 1245469013539 Q-loop/lid; other site 1245469013540 ABC transporter signature motif; other site 1245469013541 Walker B; other site 1245469013542 D-loop; other site 1245469013543 H-loop/switch region; other site 1245469013544 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1245469013545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469013546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469013547 Walker A/P-loop; other site 1245469013548 ATP binding site [chemical binding]; other site 1245469013549 Q-loop/lid; other site 1245469013550 ABC transporter signature motif; other site 1245469013551 Walker B; other site 1245469013552 D-loop; other site 1245469013553 H-loop/switch region; other site 1245469013554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469013555 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469013556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013557 dimer interface [polypeptide binding]; other site 1245469013558 conserved gate region; other site 1245469013559 putative PBP binding loops; other site 1245469013560 ABC-ATPase subunit interface; other site 1245469013561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469013562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013563 dimer interface [polypeptide binding]; other site 1245469013564 conserved gate region; other site 1245469013565 putative PBP binding loops; other site 1245469013566 ABC-ATPase subunit interface; other site 1245469013567 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469013568 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1245469013569 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 1245469013570 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469013571 tetramer interface [polypeptide binding]; other site 1245469013572 active site 1245469013573 catalytic triad [active] 1245469013574 dimer interface [polypeptide binding]; other site 1245469013575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469013576 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 1245469013577 NAD(P) binding site [chemical binding]; other site 1245469013578 catalytic residues [active] 1245469013579 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469013580 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469013581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469013582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469013583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469013584 dimerization interface [polypeptide binding]; other site 1245469013585 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469013586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469013587 membrane-bound complex binding site; other site 1245469013588 hinge residues; other site 1245469013589 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1245469013590 active site 1245469013591 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1245469013592 dimer interface [polypeptide binding]; other site 1245469013593 non-prolyl cis peptide bond; other site 1245469013594 insertion regions; other site 1245469013595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469013596 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1245469013597 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1245469013598 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469013599 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469013600 Walker A/P-loop; other site 1245469013601 ATP binding site [chemical binding]; other site 1245469013602 Q-loop/lid; other site 1245469013603 ABC transporter signature motif; other site 1245469013604 Walker B; other site 1245469013605 D-loop; other site 1245469013606 H-loop/switch region; other site 1245469013607 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469013608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013609 dimer interface [polypeptide binding]; other site 1245469013610 conserved gate region; other site 1245469013611 putative PBP binding loops; other site 1245469013612 ABC-ATPase subunit interface; other site 1245469013613 NMT1/THI5 like; Region: NMT1; pfam09084 1245469013614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469013615 substrate binding pocket [chemical binding]; other site 1245469013616 membrane-bound complex binding site; other site 1245469013617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1245469013618 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1245469013619 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 1245469013620 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1245469013621 BA14K-like protein; Region: BA14K; pfam07886 1245469013622 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469013623 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469013624 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013625 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013626 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013627 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013628 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013629 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013630 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013631 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013632 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013633 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013634 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013635 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013636 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013637 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013638 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 1245469013639 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469013640 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469013641 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1245469013642 Cadherin repeat-like domain; Region: CA_like; cl15786 1245469013643 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469013644 VCBS repeat; Region: VCBS_repeat; TIGR01965 1245469013645 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 1245469013646 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469013647 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469013648 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1245469013649 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1245469013650 putative active site [active] 1245469013651 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469013652 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1245469013653 Walker A/P-loop; other site 1245469013654 ATP binding site [chemical binding]; other site 1245469013655 Q-loop/lid; other site 1245469013656 ABC transporter signature motif; other site 1245469013657 Walker B; other site 1245469013658 D-loop; other site 1245469013659 H-loop/switch region; other site 1245469013660 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1245469013661 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1245469013662 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1245469013663 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1245469013664 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469013665 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1245469013666 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1245469013667 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469013668 Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cl00084 1245469013669 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469013670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469013671 TPR motif; other site 1245469013672 TPR repeat; Region: TPR_11; pfam13414 1245469013673 binding surface 1245469013674 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469013675 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469013676 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1245469013677 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1245469013678 CHASE2 domain; Region: CHASE2; pfam05226 1245469013679 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1245469013680 cyclase homology domain; Region: CHD; cd07302 1245469013681 nucleotidyl binding site; other site 1245469013682 metal binding site [ion binding]; metal-binding site 1245469013683 dimer interface [polypeptide binding]; other site 1245469013684 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1245469013685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469013686 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469013687 active site 1245469013688 phosphorylation site [posttranslational modification] 1245469013689 intermolecular recognition site; other site 1245469013690 dimerization interface [polypeptide binding]; other site 1245469013691 Hpt domain; Region: Hpt; pfam01627 1245469013692 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469013693 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469013694 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469013695 catalytic residue [active] 1245469013696 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1245469013697 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1245469013698 GTP cyclohydrolase I; Provisional; Region: PLN03044 1245469013699 active site 1245469013700 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1245469013701 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1245469013702 trimerization site [polypeptide binding]; other site 1245469013703 active site 1245469013704 Predicted periplasmic protein [Function unknown]; Region: COG3904 1245469013705 hypothetical protein; Validated; Region: PRK00041 1245469013706 Amino acid permease; Region: AA_permease_2; pfam13520 1245469013707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469013708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469013709 putative substrate translocation pore; other site 1245469013710 Predicted periplasmic protein [Function unknown]; Region: COG3904 1245469013711 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1245469013712 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1245469013713 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1245469013714 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1245469013715 active site 1245469013716 dimer interface [polypeptide binding]; other site 1245469013717 motif 1; other site 1245469013718 motif 2; other site 1245469013719 motif 3; other site 1245469013720 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1245469013721 anticodon binding site; other site 1245469013722 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1245469013723 putative FMN binding site [chemical binding]; other site 1245469013724 PAS domain S-box; Region: sensory_box; TIGR00229 1245469013725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469013726 putative active site [active] 1245469013727 heme pocket [chemical binding]; other site 1245469013728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469013729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469013730 metal binding site [ion binding]; metal-binding site 1245469013731 active site 1245469013732 I-site; other site 1245469013733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469013734 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1245469013735 hypothetical protein; Provisional; Region: PRK10279 1245469013736 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1245469013737 nucleophile elbow; other site 1245469013738 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469013739 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1245469013740 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1245469013741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 1245469013742 PAS domain; Region: PAS_5; pfam07310 1245469013743 AAA ATPase domain; Region: AAA_16; pfam13191 1245469013744 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1245469013745 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469013746 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469013747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469013748 TPR motif; other site 1245469013749 binding surface 1245469013750 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469013751 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469013752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1245469013753 PilZ domain; Region: PilZ; pfam07238 1245469013754 PilZ domain; Region: PilZ; pfam07238 1245469013755 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; pfam06035 1245469013756 Dienelactone hydrolase family; Region: DLH; pfam01738 1245469013757 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469013758 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1245469013759 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1245469013760 trimer interface [polypeptide binding]; other site 1245469013761 putative metal binding site [ion binding]; other site 1245469013762 Protein of unknown function (DUF3126); Region: DUF3126; pfam11324 1245469013763 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1245469013764 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1245469013765 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1245469013766 trimer interface [polypeptide binding]; other site 1245469013767 active site 1245469013768 substrate binding site [chemical binding]; other site 1245469013769 CoA binding site [chemical binding]; other site 1245469013770 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469013771 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469013772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 1245469013773 salicylate hydroxylase; Provisional; Region: PRK08163 1245469013774 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469013775 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469013776 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469013777 ligand binding site [chemical binding]; other site 1245469013778 flexible hinge region; other site 1245469013779 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469013780 putative switch regulator; other site 1245469013781 non-specific DNA interactions [nucleotide binding]; other site 1245469013782 DNA binding site [nucleotide binding] 1245469013783 sequence specific DNA binding site [nucleotide binding]; other site 1245469013784 putative cAMP binding site [chemical binding]; other site 1245469013785 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1245469013786 putative hydrophobic ligand binding site [chemical binding]; other site 1245469013787 CLM binding site; other site 1245469013788 L1 loop; other site 1245469013789 DNA binding site [nucleotide binding] 1245469013790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469013791 dimerization interface [polypeptide binding]; other site 1245469013792 putative DNA binding site [nucleotide binding]; other site 1245469013793 putative Zn2+ binding site [ion binding]; other site 1245469013794 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469013795 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469013796 dimer interface [polypeptide binding]; other site 1245469013797 putative CheW interface [polypeptide binding]; other site 1245469013798 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1245469013799 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1245469013800 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469013801 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469013802 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1245469013803 hypothetical protein; Provisional; Region: PRK07338 1245469013804 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1245469013805 metal binding site [ion binding]; metal-binding site 1245469013806 dimer interface [polypeptide binding]; other site 1245469013807 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469013808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013809 dimer interface [polypeptide binding]; other site 1245469013810 conserved gate region; other site 1245469013811 putative PBP binding loops; other site 1245469013812 ABC-ATPase subunit interface; other site 1245469013813 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469013814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469013815 dimer interface [polypeptide binding]; other site 1245469013816 conserved gate region; other site 1245469013817 putative PBP binding loops; other site 1245469013818 ABC-ATPase subunit interface; other site 1245469013819 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469013820 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469013821 Walker A/P-loop; other site 1245469013822 ATP binding site [chemical binding]; other site 1245469013823 Q-loop/lid; other site 1245469013824 ABC transporter signature motif; other site 1245469013825 Walker B; other site 1245469013826 D-loop; other site 1245469013827 H-loop/switch region; other site 1245469013828 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469013829 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469013830 Walker A/P-loop; other site 1245469013831 ATP binding site [chemical binding]; other site 1245469013832 Q-loop/lid; other site 1245469013833 ABC transporter signature motif; other site 1245469013834 Walker B; other site 1245469013835 D-loop; other site 1245469013836 H-loop/switch region; other site 1245469013837 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469013838 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1245469013839 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1245469013840 MlrC C-terminus; Region: MlrC_C; pfam07171 1245469013841 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469013842 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1245469013843 metal binding site [ion binding]; metal-binding site 1245469013844 putative dimer interface [polypeptide binding]; other site 1245469013845 amidase; Provisional; Region: PRK07042 1245469013846 Amidase; Region: Amidase; pfam01425 1245469013847 enoyl-CoA hydratase; Provisional; Region: PRK08260 1245469013848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469013849 substrate binding site [chemical binding]; other site 1245469013850 oxyanion hole (OAH) forming residues; other site 1245469013851 trimer interface [polypeptide binding]; other site 1245469013852 Nitrate and nitrite sensing; Region: NIT; pfam08376 1245469013853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469013854 dimerization interface [polypeptide binding]; other site 1245469013855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469013856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469013857 dimer interface [polypeptide binding]; other site 1245469013858 putative CheW interface [polypeptide binding]; other site 1245469013859 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1245469013860 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469013861 NAD(P) binding site [chemical binding]; other site 1245469013862 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1245469013863 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1245469013864 putative catalytic residue [active] 1245469013865 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1245469013866 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1245469013867 C-terminal domain interface [polypeptide binding]; other site 1245469013868 GSH binding site (G-site) [chemical binding]; other site 1245469013869 dimer interface [polypeptide binding]; other site 1245469013870 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469013871 N-terminal domain interface [polypeptide binding]; other site 1245469013872 dimer interface [polypeptide binding]; other site 1245469013873 substrate binding pocket (H-site) [chemical binding]; other site 1245469013874 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1245469013875 substrate binding site [chemical binding]; other site 1245469013876 methionine synthase; Provisional; Region: PRK01207 1245469013877 THF binding site; other site 1245469013878 zinc-binding site [ion binding]; other site 1245469013879 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1245469013880 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1245469013881 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469013882 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469013883 active site 1245469013884 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1245469013885 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1245469013886 putative MPT binding site; other site 1245469013887 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1245469013888 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1245469013889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1245469013890 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1245469013891 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1245469013892 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1245469013893 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 1245469013894 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1245469013895 active site 1245469013896 classical (c) SDRs; Region: SDR_c; cd05233 1245469013897 NAD(P) binding site [chemical binding]; other site 1245469013898 active site 1245469013899 H+ Antiporter protein; Region: 2A0121; TIGR00900 1245469013900 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1245469013901 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1245469013902 Nucleoside recognition; Region: Gate; pfam07670 1245469013903 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1245469013904 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1245469013905 Cupin domain; Region: Cupin_2; cl17218 1245469013906 Usg-like family; Region: Usg; pfam06233 1245469013907 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1245469013908 oligomerisation interface [polypeptide binding]; other site 1245469013909 mobile loop; other site 1245469013910 roof hairpin; other site 1245469013911 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1245469013912 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1245469013913 ring oligomerisation interface [polypeptide binding]; other site 1245469013914 ATP/Mg binding site [chemical binding]; other site 1245469013915 stacking interactions; other site 1245469013916 hinge regions; other site 1245469013917 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1245469013918 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1245469013919 Catalytic site [active] 1245469013920 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1245469013921 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1245469013922 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1245469013923 hypothetical protein; Reviewed; Region: PRK09588 1245469013924 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1245469013925 GIY-YIG motif/motif A; other site 1245469013926 putative active site [active] 1245469013927 putative metal binding site [ion binding]; other site 1245469013928 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1245469013929 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1245469013930 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1245469013931 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1245469013932 active site 1245469013933 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 1245469013934 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1245469013935 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1245469013936 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1245469013937 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1245469013938 Ligand binding site; other site 1245469013939 Putative Catalytic site; other site 1245469013940 DXD motif; other site 1245469013941 Predicted membrane protein [Function unknown]; Region: COG2246 1245469013942 GtrA-like protein; Region: GtrA; pfam04138 1245469013943 Protein of unknown function DUF72; Region: DUF72; pfam01904 1245469013944 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1245469013945 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1245469013946 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469013947 cyclase homology domain; Region: CHD; cd07302 1245469013948 nucleotidyl binding site; other site 1245469013949 metal binding site [ion binding]; metal-binding site 1245469013950 dimer interface [polypeptide binding]; other site 1245469013951 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1245469013952 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1245469013953 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1245469013954 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1245469013955 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1245469013956 Walker A/P-loop; other site 1245469013957 ATP binding site [chemical binding]; other site 1245469013958 Q-loop/lid; other site 1245469013959 ABC transporter signature motif; other site 1245469013960 Walker B; other site 1245469013961 D-loop; other site 1245469013962 H-loop/switch region; other site 1245469013963 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469013964 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469013965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469013966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469013967 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1245469013968 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1245469013969 NAD binding site [chemical binding]; other site 1245469013970 substrate binding site [chemical binding]; other site 1245469013971 catalytic Zn binding site [ion binding]; other site 1245469013972 tetramer interface [polypeptide binding]; other site 1245469013973 structural Zn binding site [ion binding]; other site 1245469013974 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 1245469013975 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1245469013976 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1245469013977 putative MPT binding site; other site 1245469013978 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1245469013979 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1245469013980 Ligand binding site; other site 1245469013981 metal-binding site 1245469013982 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1245469013983 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1245469013984 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1245469013985 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1245469013986 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1245469013987 metal ion-dependent adhesion site (MIDAS); other site 1245469013988 MoxR-like ATPases [General function prediction only]; Region: COG0714 1245469013989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469013990 Walker A motif; other site 1245469013991 ATP binding site [chemical binding]; other site 1245469013992 Walker B motif; other site 1245469013993 arginine finger; other site 1245469013994 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469013995 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1245469013996 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469013997 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469013998 catalytic loop [active] 1245469013999 iron binding site [ion binding]; other site 1245469014000 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469014001 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 1245469014002 putative hydrophobic ligand binding site [chemical binding]; other site 1245469014003 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1245469014004 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469014005 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469014006 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469014007 TM-ABC transporter signature motif; other site 1245469014008 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1245469014009 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1245469014010 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469014011 TM-ABC transporter signature motif; other site 1245469014012 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469014013 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469014014 Walker A/P-loop; other site 1245469014015 ATP binding site [chemical binding]; other site 1245469014016 Q-loop/lid; other site 1245469014017 ABC transporter signature motif; other site 1245469014018 Walker B; other site 1245469014019 D-loop; other site 1245469014020 H-loop/switch region; other site 1245469014021 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469014022 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469014023 Walker A/P-loop; other site 1245469014024 ATP binding site [chemical binding]; other site 1245469014025 Q-loop/lid; other site 1245469014026 ABC transporter signature motif; other site 1245469014027 Walker B; other site 1245469014028 D-loop; other site 1245469014029 H-loop/switch region; other site 1245469014030 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1245469014031 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1245469014032 dimerization interface [polypeptide binding]; other site 1245469014033 ligand binding site [chemical binding]; other site 1245469014034 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469014035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469014036 active site 1245469014037 phosphorylation site [posttranslational modification] 1245469014038 intermolecular recognition site; other site 1245469014039 dimerization interface [polypeptide binding]; other site 1245469014040 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1245469014041 PAS domain S-box; Region: sensory_box; TIGR00229 1245469014042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469014043 putative active site [active] 1245469014044 heme pocket [chemical binding]; other site 1245469014045 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1245469014046 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469014047 putative active site [active] 1245469014048 heme pocket [chemical binding]; other site 1245469014049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469014050 dimer interface [polypeptide binding]; other site 1245469014051 phosphorylation site [posttranslational modification] 1245469014052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469014053 ATP binding site [chemical binding]; other site 1245469014054 Mg2+ binding site [ion binding]; other site 1245469014055 G-X-G motif; other site 1245469014056 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469014057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469014058 active site 1245469014059 phosphorylation site [posttranslational modification] 1245469014060 intermolecular recognition site; other site 1245469014061 dimerization interface [polypeptide binding]; other site 1245469014062 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1245469014063 putative active site pocket [active] 1245469014064 cleavage site 1245469014065 EF hand; Region: EF_hand_3; pfam13202 1245469014066 Ca2+ binding site [ion binding]; other site 1245469014067 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1245469014068 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1245469014069 substrate binding site [chemical binding]; other site 1245469014070 hexamer interface [polypeptide binding]; other site 1245469014071 metal binding site [ion binding]; metal-binding site 1245469014072 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1245469014073 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 1245469014074 hypothetical protein; Provisional; Region: PRK11171 1245469014075 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1245469014076 Cupin domain; Region: Cupin_2; pfam07883 1245469014077 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1245469014078 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469014079 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1245469014080 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1245469014081 active site 1245469014082 ATP binding site [chemical binding]; other site 1245469014083 substrate binding site [chemical binding]; other site 1245469014084 activation loop (A-loop); other site 1245469014085 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1245469014086 Ligand Binding Site [chemical binding]; other site 1245469014087 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469014088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1245469014089 active site 1245469014090 metal binding site [ion binding]; metal-binding site 1245469014091 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 1245469014092 active site 1245469014093 Zn binding site [ion binding]; other site 1245469014094 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469014095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469014096 ATP binding site [chemical binding]; other site 1245469014097 Mg2+ binding site [ion binding]; other site 1245469014098 G-X-G motif; other site 1245469014099 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469014100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469014101 active site 1245469014102 phosphorylation site [posttranslational modification] 1245469014103 intermolecular recognition site; other site 1245469014104 dimerization interface [polypeptide binding]; other site 1245469014105 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469014106 DNA binding residues [nucleotide binding] 1245469014107 dimerization interface [polypeptide binding]; other site 1245469014108 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469014109 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469014110 adenylosuccinate lyase; Provisional; Region: PRK07492 1245469014111 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1245469014112 tetramer interface [polypeptide binding]; other site 1245469014113 active site 1245469014114 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1245469014115 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1245469014116 FtsH Extracellular; Region: FtsH_ext; pfam06480 1245469014117 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1245469014118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469014119 Walker A motif; other site 1245469014120 ATP binding site [chemical binding]; other site 1245469014121 Walker B motif; other site 1245469014122 arginine finger; other site 1245469014123 Peptidase family M41; Region: Peptidase_M41; pfam01434 1245469014124 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1245469014125 putative lipid kinase; Reviewed; Region: PRK13057 1245469014126 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1245469014127 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1245469014128 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1245469014129 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1245469014130 putative active site [active] 1245469014131 putative metal binding residues [ion binding]; other site 1245469014132 signature motif; other site 1245469014133 putative triphosphate binding site [ion binding]; other site 1245469014134 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1245469014135 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469014136 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1245469014137 metal binding site [ion binding]; metal-binding site 1245469014138 putative dimer interface [polypeptide binding]; other site 1245469014139 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1245469014140 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469014141 putative NAD(P) binding site [chemical binding]; other site 1245469014142 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1245469014143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469014144 HWE histidine kinase; Region: HWE_HK; smart00911 1245469014145 Staphylococcal nuclease homologues; Region: SNc; smart00318 1245469014146 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1245469014147 Catalytic site; other site 1245469014148 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1245469014149 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1245469014150 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469014151 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 1245469014152 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1245469014153 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1245469014154 Transposase IS200 like; Region: Y1_Tnp; cl00848 1245469014155 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1245469014156 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469014157 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1245469014158 putative hydrophobic ligand binding site [chemical binding]; other site 1245469014159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469014160 putative DNA binding site [nucleotide binding]; other site 1245469014161 dimerization interface [polypeptide binding]; other site 1245469014162 putative Zn2+ binding site [ion binding]; other site 1245469014163 glutamate racemase; Provisional; Region: PRK00865 1245469014164 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1245469014165 Cupin domain; Region: Cupin_2; pfam07883 1245469014166 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1245469014167 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1245469014168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469014169 RNA binding surface [nucleotide binding]; other site 1245469014170 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1245469014171 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1245469014172 tetramer interface [polypeptide binding]; other site 1245469014173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469014174 catalytic residue [active] 1245469014175 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469014176 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469014177 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1245469014178 putative active site [active] 1245469014179 putative ADP-ribose binding site [chemical binding]; other site 1245469014180 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1245469014181 putative GSH binding site [chemical binding]; other site 1245469014182 catalytic residues [active] 1245469014183 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1245469014184 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1245469014185 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1245469014186 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1245469014187 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1245469014188 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1245469014189 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1245469014190 hypothetical protein; Provisional; Region: PRK13682 1245469014191 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1245469014192 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1245469014193 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1245469014194 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1245469014195 dimerization interface [polypeptide binding]; other site 1245469014196 ATP binding site [chemical binding]; other site 1245469014197 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1245469014198 dimerization interface [polypeptide binding]; other site 1245469014199 ATP binding site [chemical binding]; other site 1245469014200 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469014201 CoenzymeA binding site [chemical binding]; other site 1245469014202 subunit interaction site [polypeptide binding]; other site 1245469014203 PHB binding site; other site 1245469014204 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 1245469014205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469014206 binding surface 1245469014207 TPR motif; other site 1245469014208 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469014209 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469014210 active site 1245469014211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469014212 classical (c) SDRs; Region: SDR_c; cd05233 1245469014213 NAD(P) binding site [chemical binding]; other site 1245469014214 active site 1245469014215 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1245469014216 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1245469014217 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1245469014218 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469014219 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1245469014220 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469014221 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1245469014222 putative dimerization interface [polypeptide binding]; other site 1245469014223 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1245469014224 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469014225 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1245469014226 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1245469014227 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1245469014228 putative active site [active] 1245469014229 catalytic triad [active] 1245469014230 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1245469014231 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1245469014232 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1245469014233 ATP binding site [chemical binding]; other site 1245469014234 active site 1245469014235 substrate binding site [chemical binding]; other site 1245469014236 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 1245469014237 cyanate hydratase; Validated; Region: PRK02866 1245469014238 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1245469014239 oligomer interface [polypeptide binding]; other site 1245469014240 active site 1245469014241 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469014242 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469014243 Walker A/P-loop; other site 1245469014244 ATP binding site [chemical binding]; other site 1245469014245 Q-loop/lid; other site 1245469014246 ABC transporter signature motif; other site 1245469014247 Walker B; other site 1245469014248 D-loop; other site 1245469014249 H-loop/switch region; other site 1245469014250 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469014251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469014252 dimer interface [polypeptide binding]; other site 1245469014253 conserved gate region; other site 1245469014254 putative PBP binding loops; other site 1245469014255 ABC-ATPase subunit interface; other site 1245469014256 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469014257 NMT1-like family; Region: NMT1_2; pfam13379 1245469014258 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1245469014259 Rhodanese-like domain; Region: Rhodanese; pfam00581 1245469014260 active site residue [active] 1245469014261 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1245469014262 active site residue [active] 1245469014263 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469014264 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469014265 active site 1245469014266 OsmC-like protein; Region: OsmC; pfam02566 1245469014267 putative transcriptional regulator; Provisional; Region: PRK11640 1245469014268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469014269 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469014270 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469014271 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469014272 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469014273 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1245469014274 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1245469014275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469014276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469014277 Walker A/P-loop; other site 1245469014278 ATP binding site [chemical binding]; other site 1245469014279 Q-loop/lid; other site 1245469014280 ABC transporter signature motif; other site 1245469014281 Walker B; other site 1245469014282 D-loop; other site 1245469014283 H-loop/switch region; other site 1245469014284 Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051 1245469014285 catalytic site [active] 1245469014286 lipoprotein NlpI; Provisional; Region: PRK11189 1245469014287 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1245469014288 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1245469014289 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1245469014290 putative active site [active] 1245469014291 isocitrate dehydrogenase; Validated; Region: PRK08299 1245469014292 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 1245469014293 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1245469014294 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469014295 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1245469014296 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1245469014297 Walker A/P-loop; other site 1245469014298 ATP binding site [chemical binding]; other site 1245469014299 Q-loop/lid; other site 1245469014300 ABC transporter signature motif; other site 1245469014301 Walker B; other site 1245469014302 D-loop; other site 1245469014303 H-loop/switch region; other site 1245469014304 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469014305 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1245469014306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469014307 dimer interface [polypeptide binding]; other site 1245469014308 conserved gate region; other site 1245469014309 putative PBP binding loops; other site 1245469014310 ABC-ATPase subunit interface; other site 1245469014311 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469014312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469014313 substrate binding pocket [chemical binding]; other site 1245469014314 membrane-bound complex binding site; other site 1245469014315 hinge residues; other site 1245469014316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469014317 sequence-specific DNA binding site [nucleotide binding]; other site 1245469014318 salt bridge; other site 1245469014319 Cupin domain; Region: Cupin_2; pfam07883 1245469014320 Copper resistance protein D; Region: CopD; cl00563 1245469014321 CopC domain; Region: CopC; pfam04234 1245469014322 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1245469014323 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1245469014324 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469014325 substrate binding pocket [chemical binding]; other site 1245469014326 membrane-bound complex binding site; other site 1245469014327 hinge residues; other site 1245469014328 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 1245469014329 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469014330 cyclase homology domain; Region: CHD; cd07302 1245469014331 nucleotidyl binding site; other site 1245469014332 metal binding site [ion binding]; metal-binding site 1245469014333 dimer interface [polypeptide binding]; other site 1245469014334 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1245469014335 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 1245469014336 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1245469014337 metal binding triad; other site 1245469014338 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1245469014339 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1245469014340 metal binding triad; other site 1245469014341 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1245469014342 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469014343 dimerization interface [polypeptide binding]; other site 1245469014344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469014345 dimer interface [polypeptide binding]; other site 1245469014346 phosphorylation site [posttranslational modification] 1245469014347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469014348 ATP binding site [chemical binding]; other site 1245469014349 Mg2+ binding site [ion binding]; other site 1245469014350 G-X-G motif; other site 1245469014351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469014352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469014353 active site 1245469014354 phosphorylation site [posttranslational modification] 1245469014355 intermolecular recognition site; other site 1245469014356 dimerization interface [polypeptide binding]; other site 1245469014357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469014358 DNA binding site [nucleotide binding] 1245469014359 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1245469014360 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469014361 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469014362 protein binding site [polypeptide binding]; other site 1245469014363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469014364 protein binding site [polypeptide binding]; other site 1245469014365 Glucuronate isomerase; Region: UxaC; cl00829 1245469014366 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1245469014367 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469014368 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469014369 dimerization interface [polypeptide binding]; other site 1245469014370 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014371 dimer interface [polypeptide binding]; other site 1245469014372 putative CheW interface [polypeptide binding]; other site 1245469014373 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469014374 dimerization interface [polypeptide binding]; other site 1245469014375 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469014376 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014377 dimer interface [polypeptide binding]; other site 1245469014378 putative CheW interface [polypeptide binding]; other site 1245469014379 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1245469014380 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1245469014381 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 1245469014382 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 1245469014383 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 1245469014384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469014385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469014386 ATP binding site [chemical binding]; other site 1245469014387 Mg2+ binding site [ion binding]; other site 1245469014388 G-X-G motif; other site 1245469014389 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469014390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469014391 active site 1245469014392 phosphorylation site [posttranslational modification] 1245469014393 intermolecular recognition site; other site 1245469014394 dimerization interface [polypeptide binding]; other site 1245469014395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469014396 DNA binding site [nucleotide binding] 1245469014397 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 1245469014398 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1245469014399 putative DNA binding site [nucleotide binding]; other site 1245469014400 putative homodimer interface [polypeptide binding]; other site 1245469014401 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469014402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469014403 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1245469014404 putative effector binding pocket; other site 1245469014405 putative dimerization interface [polypeptide binding]; other site 1245469014406 Porin subfamily; Region: Porin_2; pfam02530 1245469014407 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 1245469014408 thymidine phosphorylase; Provisional; Region: PRK04350 1245469014409 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1245469014410 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1245469014411 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1245469014412 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1245469014413 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469014414 Beta-Casp domain; Region: Beta-Casp; smart01027 1245469014415 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1245469014416 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469014417 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469014418 ligand binding site [chemical binding]; other site 1245469014419 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1245469014420 Uncharacterized conserved protein [Function unknown]; Region: COG3743 1245469014421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469014422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469014423 putative substrate translocation pore; other site 1245469014424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469014425 hypothetical protein; Provisional; Region: PRK05170 1245469014426 Transglycosylase; Region: Transgly; pfam00912 1245469014427 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1245469014428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1245469014429 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1245469014430 Predicted integral membrane protein [Function unknown]; Region: COG5436 1245469014431 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1245469014432 putative active site [active] 1245469014433 putative metal binding residues [ion binding]; other site 1245469014434 signature motif; other site 1245469014435 putative dimer interface [polypeptide binding]; other site 1245469014436 putative phosphate binding site [ion binding]; other site 1245469014437 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1245469014438 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1245469014439 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1245469014440 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469014441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469014442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469014443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469014444 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 1245469014445 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469014446 PAS domain S-box; Region: sensory_box; TIGR00229 1245469014447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469014448 putative active site [active] 1245469014449 heme pocket [chemical binding]; other site 1245469014450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469014451 dimer interface [polypeptide binding]; other site 1245469014452 phosphorylation site [posttranslational modification] 1245469014453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469014454 ATP binding site [chemical binding]; other site 1245469014455 Mg2+ binding site [ion binding]; other site 1245469014456 G-X-G motif; other site 1245469014457 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1245469014458 Predicted transcriptional regulator [Transcription]; Region: COG4957 1245469014459 aldolase II superfamily protein; Provisional; Region: PRK07044 1245469014460 intersubunit interface [polypeptide binding]; other site 1245469014461 active site 1245469014462 Zn2+ binding site [ion binding]; other site 1245469014463 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1245469014464 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1245469014465 putative dimer interface [polypeptide binding]; other site 1245469014466 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1245469014467 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469014468 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469014469 protein binding site [polypeptide binding]; other site 1245469014470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469014471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469014472 metal binding site [ion binding]; metal-binding site 1245469014473 active site 1245469014474 I-site; other site 1245469014475 hypothetical protein; Validated; Region: PRK09104 1245469014476 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1245469014477 metal binding site [ion binding]; metal-binding site 1245469014478 putative dimer interface [polypeptide binding]; other site 1245469014479 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1245469014480 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1245469014481 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1245469014482 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1245469014483 dihydropteroate synthase; Region: DHPS; TIGR01496 1245469014484 substrate binding pocket [chemical binding]; other site 1245469014485 dimer interface [polypeptide binding]; other site 1245469014486 inhibitor binding site; inhibition site 1245469014487 Dihydroneopterin aldolase; Region: FolB; pfam02152 1245469014488 active site 1245469014489 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1245469014490 catalytic center binding site [active] 1245469014491 ATP binding site [chemical binding]; other site 1245469014492 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1245469014493 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1245469014494 heterodimer interface [polypeptide binding]; other site 1245469014495 substrate interaction site [chemical binding]; other site 1245469014496 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469014497 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1245469014498 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1245469014499 active site 1245469014500 substrate binding site [chemical binding]; other site 1245469014501 coenzyme B12 binding site [chemical binding]; other site 1245469014502 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1245469014503 B12 binding site [chemical binding]; other site 1245469014504 cobalt ligand [ion binding]; other site 1245469014505 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1245469014506 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1245469014507 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1245469014508 active site 1245469014509 NTP binding site [chemical binding]; other site 1245469014510 metal binding triad [ion binding]; metal-binding site 1245469014511 antibiotic binding site [chemical binding]; other site 1245469014512 Protein of unknown function DUF86; Region: DUF86; cl01031 1245469014513 ArgK protein; Region: ArgK; pfam03308 1245469014514 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1245469014515 Walker A; other site 1245469014516 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1245469014517 G4 box; other site 1245469014518 G5 box; other site 1245469014519 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1245469014520 putative substrate binding pocket [chemical binding]; other site 1245469014521 AC domain interface; other site 1245469014522 catalytic triad [active] 1245469014523 AB domain interface; other site 1245469014524 interchain disulfide; other site 1245469014525 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 1245469014526 putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807 1245469014527 putative cofactor-binding repeat; Region: RR_fam_repeat; TIGR03807 1245469014528 EamA-like transporter family; Region: EamA; pfam00892 1245469014529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469014530 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469014531 TIGR03809 family protein; Region: TIGR03809 1245469014532 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 1245469014533 active site 1245469014534 catalytic triad [active] 1245469014535 RNA polymerase sigma factor; Provisional; Region: PRK12515 1245469014536 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469014537 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469014538 DNA binding residues [nucleotide binding] 1245469014539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469014540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469014541 metal binding site [ion binding]; metal-binding site 1245469014542 active site 1245469014543 I-site; other site 1245469014544 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 1245469014545 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 1245469014546 RNA polymerase sigma factor; Provisional; Region: PRK12512 1245469014547 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469014548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469014549 DNA binding residues [nucleotide binding] 1245469014550 enoyl-CoA hydratase; Provisional; Region: PRK05862 1245469014551 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469014552 substrate binding site [chemical binding]; other site 1245469014553 oxyanion hole (OAH) forming residues; other site 1245469014554 trimer interface [polypeptide binding]; other site 1245469014555 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1245469014556 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469014557 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1245469014558 active site 1245469014559 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1245469014560 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1245469014561 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1245469014562 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469014563 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 1245469014564 ligand binding site [chemical binding]; other site 1245469014565 regulator interaction site; other site 1245469014566 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1245469014567 ANTAR domain; Region: ANTAR; pfam03861 1245469014568 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469014569 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 1245469014570 putative active site [active] 1245469014571 catalytic triad [active] 1245469014572 putative dimer interface [polypeptide binding]; other site 1245469014573 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469014574 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1245469014575 putative ligand binding site [chemical binding]; other site 1245469014576 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469014577 TM-ABC transporter signature motif; other site 1245469014578 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469014579 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469014580 TM-ABC transporter signature motif; other site 1245469014581 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469014582 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469014583 Walker A/P-loop; other site 1245469014584 ATP binding site [chemical binding]; other site 1245469014585 Q-loop/lid; other site 1245469014586 ABC transporter signature motif; other site 1245469014587 Walker B; other site 1245469014588 D-loop; other site 1245469014589 H-loop/switch region; other site 1245469014590 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469014591 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469014592 Walker A/P-loop; other site 1245469014593 ATP binding site [chemical binding]; other site 1245469014594 Q-loop/lid; other site 1245469014595 ABC transporter signature motif; other site 1245469014596 Walker B; other site 1245469014597 D-loop; other site 1245469014598 H-loop/switch region; other site 1245469014599 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1245469014600 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1245469014601 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1245469014602 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469014603 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1245469014604 putative active site [active] 1245469014605 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1245469014606 putative PHP Thumb interface [polypeptide binding]; other site 1245469014607 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1245469014608 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1245469014609 generic binding surface I; other site 1245469014610 generic binding surface II; other site 1245469014611 DNA Polymerase Y-family; Region: PolY_like; cd03468 1245469014612 active site 1245469014613 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1245469014614 DNA binding site [nucleotide binding] 1245469014615 Uncharacterized conserved protein [Function unknown]; Region: COG4544 1245469014616 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1245469014617 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469014618 FeS/SAM binding site; other site 1245469014619 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 1245469014620 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1245469014621 Fe-S cluster binding site [ion binding]; other site 1245469014622 active site 1245469014623 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469014624 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1245469014625 metal binding site [ion binding]; metal-binding site 1245469014626 putative dimer interface [polypeptide binding]; other site 1245469014627 choline dehydrogenase; Validated; Region: PRK02106 1245469014628 lycopene cyclase; Region: lycopene_cycl; TIGR01789 1245469014629 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469014630 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1245469014631 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469014632 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469014633 active site 1245469014634 metal binding site [ion binding]; metal-binding site 1245469014635 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1245469014636 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1245469014637 RNA polymerase sigma factor; Provisional; Region: PRK11924 1245469014638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469014639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469014640 DNA binding residues [nucleotide binding] 1245469014641 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1245469014642 Putative zinc-finger; Region: zf-HC2; pfam13490 1245469014643 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469014644 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1245469014645 inhibitor-cofactor binding pocket; inhibition site 1245469014646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469014647 catalytic residue [active] 1245469014648 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469014649 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1245469014650 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1245469014651 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1245469014652 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 1245469014653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469014654 FeS/SAM binding site; other site 1245469014655 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 1245469014656 hypothetical protein; Provisional; Region: PRK07077 1245469014657 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469014658 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1245469014659 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1245469014660 active site lid residues [active] 1245469014661 substrate binding pocket [chemical binding]; other site 1245469014662 catalytic residues [active] 1245469014663 substrate-Mg2+ binding site; other site 1245469014664 aspartate-rich region 1; other site 1245469014665 aspartate-rich region 2; other site 1245469014666 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1245469014667 active site lid residues [active] 1245469014668 substrate binding pocket [chemical binding]; other site 1245469014669 catalytic residues [active] 1245469014670 substrate-Mg2+ binding site; other site 1245469014671 aspartate-rich region 1; other site 1245469014672 aspartate-rich region 2; other site 1245469014673 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1245469014674 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1245469014675 B12 binding site [chemical binding]; other site 1245469014676 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1245469014677 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 1245469014678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469014679 dimerization interface [polypeptide binding]; other site 1245469014680 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469014681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014682 dimer interface [polypeptide binding]; other site 1245469014683 putative CheW interface [polypeptide binding]; other site 1245469014684 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1245469014685 GTP cyclohydrolase I; Provisional; Region: PLN03044 1245469014686 active site 1245469014687 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1245469014688 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469014689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469014690 DNA binding residues [nucleotide binding] 1245469014691 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1245469014692 Putative zinc-finger; Region: zf-HC2; pfam13490 1245469014693 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1245469014694 RNA polymerase sigma factor; Provisional; Region: PRK12514 1245469014695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469014696 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1245469014697 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1245469014698 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1245469014699 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 1245469014700 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1245469014701 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1245469014702 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 1245469014703 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1245469014704 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1245469014705 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1245469014706 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1245469014707 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1245469014708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1245469014709 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1245469014710 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1245469014711 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1245469014712 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1245469014713 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1245469014714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1245469014715 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1245469014716 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1245469014717 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1245469014718 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1245469014719 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 1245469014720 MarR family; Region: MarR_2; cl17246 1245469014721 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469014722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1245469014723 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1245469014724 putative substrate binding pocket [chemical binding]; other site 1245469014725 trimer interface [polypeptide binding]; other site 1245469014726 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1245469014727 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1245469014728 NAD binding site [chemical binding]; other site 1245469014729 catalytic residues [active] 1245469014730 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469014731 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469014732 hypothetical protein; Provisional; Region: PRK08266 1245469014733 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469014734 PYR/PP interface [polypeptide binding]; other site 1245469014735 dimer interface [polypeptide binding]; other site 1245469014736 TPP binding site [chemical binding]; other site 1245469014737 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469014738 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1245469014739 TPP-binding site [chemical binding]; other site 1245469014740 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469014741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469014742 putative substrate translocation pore; other site 1245469014743 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1245469014744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1245469014745 Transglycosylase; Region: Transgly; pfam00912 1245469014746 amidase; Provisional; Region: PRK07056 1245469014747 Amidase; Region: Amidase; cl11426 1245469014748 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1245469014749 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1245469014750 DUF35 OB-fold domain; Region: DUF35; pfam01796 1245469014751 thiolase; Provisional; Region: PRK06158 1245469014752 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1245469014753 active site 1245469014754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469014755 short chain dehydrogenase; Provisional; Region: PRK07791 1245469014756 NAD(P) binding site [chemical binding]; other site 1245469014757 active site 1245469014758 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1245469014759 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1245469014760 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1245469014761 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 1245469014762 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469014763 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469014764 acyl-activating enzyme (AAE) consensus motif; other site 1245469014765 putative AMP binding site [chemical binding]; other site 1245469014766 putative active site [active] 1245469014767 putative CoA binding site [chemical binding]; other site 1245469014768 enoyl-CoA hydratase; Provisional; Region: PRK07509 1245469014769 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469014770 substrate binding site [chemical binding]; other site 1245469014771 oxyanion hole (OAH) forming residues; other site 1245469014772 trimer interface [polypeptide binding]; other site 1245469014773 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1245469014774 short chain dehydrogenase; Provisional; Region: PRK07677 1245469014775 NAD(P) binding site [chemical binding]; other site 1245469014776 substrate binding site [chemical binding]; other site 1245469014777 homotetramer interface [polypeptide binding]; other site 1245469014778 active site 1245469014779 homodimer interface [polypeptide binding]; other site 1245469014780 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1245469014781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469014782 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469014783 acyl-activating enzyme (AAE) consensus motif; other site 1245469014784 acyl-activating enzyme (AAE) consensus motif; other site 1245469014785 putative AMP binding site [chemical binding]; other site 1245469014786 putative active site [active] 1245469014787 putative CoA binding site [chemical binding]; other site 1245469014788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469014789 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1245469014790 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1245469014791 active site 1245469014792 enoyl-CoA hydratase; Provisional; Region: PRK06494 1245469014793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469014794 substrate binding site [chemical binding]; other site 1245469014795 oxyanion hole (OAH) forming residues; other site 1245469014796 trimer interface [polypeptide binding]; other site 1245469014797 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1245469014798 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1245469014799 putative active site [active] 1245469014800 putative substrate binding site [chemical binding]; other site 1245469014801 ATP binding site [chemical binding]; other site 1245469014802 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469014803 enoyl-CoA hydratase; Provisional; Region: PRK05981 1245469014804 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469014805 substrate binding site [chemical binding]; other site 1245469014806 oxyanion hole (OAH) forming residues; other site 1245469014807 trimer interface [polypeptide binding]; other site 1245469014808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469014809 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1245469014810 NAD(P) binding site [chemical binding]; other site 1245469014811 active site 1245469014812 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469014813 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1245469014814 Predicted membrane protein [Function unknown]; Region: COG3748 1245469014815 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1245469014816 sulfite oxidase; Provisional; Region: PLN00177 1245469014817 Moco binding site; other site 1245469014818 metal coordination site [ion binding]; other site 1245469014819 putative S-transferase; Provisional; Region: PRK11752 1245469014820 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1245469014821 C-terminal domain interface [polypeptide binding]; other site 1245469014822 GSH binding site (G-site) [chemical binding]; other site 1245469014823 dimer interface [polypeptide binding]; other site 1245469014824 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1245469014825 dimer interface [polypeptide binding]; other site 1245469014826 N-terminal domain interface [polypeptide binding]; other site 1245469014827 active site 1245469014828 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1245469014829 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1245469014830 active site 1245469014831 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1245469014832 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1245469014833 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1245469014834 HSP70 interaction site [polypeptide binding]; other site 1245469014835 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469014836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469014837 binding surface 1245469014838 TPR motif; other site 1245469014839 TPR repeat; Region: TPR_11; pfam13414 1245469014840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469014841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469014842 PAS fold; Region: PAS_3; pfam08447 1245469014843 putative active site [active] 1245469014844 heme pocket [chemical binding]; other site 1245469014845 HAMP domain; Region: HAMP; pfam00672 1245469014846 dimerization interface [polypeptide binding]; other site 1245469014847 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014848 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469014849 dimer interface [polypeptide binding]; other site 1245469014850 putative CheW interface [polypeptide binding]; other site 1245469014851 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469014852 CHASE3 domain; Region: CHASE3; pfam05227 1245469014853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469014854 dimerization interface [polypeptide binding]; other site 1245469014855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469014856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014857 dimer interface [polypeptide binding]; other site 1245469014858 putative CheW interface [polypeptide binding]; other site 1245469014859 HAMP domain; Region: HAMP; pfam00672 1245469014860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014861 dimer interface [polypeptide binding]; other site 1245469014862 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469014863 putative CheW interface [polypeptide binding]; other site 1245469014864 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469014865 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469014866 putative ligand binding site [chemical binding]; other site 1245469014867 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1245469014868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469014869 dimerization interface [polypeptide binding]; other site 1245469014870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469014871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014872 dimer interface [polypeptide binding]; other site 1245469014873 putative CheW interface [polypeptide binding]; other site 1245469014874 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469014875 HAMP domain; Region: HAMP; pfam00672 1245469014876 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014877 dimer interface [polypeptide binding]; other site 1245469014878 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469014879 putative CheW interface [polypeptide binding]; other site 1245469014880 HAMP domain; Region: HAMP; pfam00672 1245469014881 dimerization interface [polypeptide binding]; other site 1245469014882 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469014883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469014884 dimer interface [polypeptide binding]; other site 1245469014885 putative CheW interface [polypeptide binding]; other site 1245469014886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1245469014887 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1245469014888 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469014889 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469014890 putative aldolase; Validated; Region: PRK08130 1245469014891 intersubunit interface [polypeptide binding]; other site 1245469014892 active site 1245469014893 Zn2+ binding site [ion binding]; other site 1245469014894 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469014895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469014896 Walker A/P-loop; other site 1245469014897 ATP binding site [chemical binding]; other site 1245469014898 Q-loop/lid; other site 1245469014899 ABC transporter signature motif; other site 1245469014900 Walker B; other site 1245469014901 D-loop; other site 1245469014902 H-loop/switch region; other site 1245469014903 TOBE domain; Region: TOBE_2; pfam08402 1245469014904 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1245469014905 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469014906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469014907 dimer interface [polypeptide binding]; other site 1245469014908 putative PBP binding loops; other site 1245469014909 ABC-ATPase subunit interface; other site 1245469014910 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469014911 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1245469014912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469014913 dimer interface [polypeptide binding]; other site 1245469014914 ABC-ATPase subunit interface; other site 1245469014915 putative PBP binding loops; other site 1245469014916 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469014917 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469014918 Walker A/P-loop; other site 1245469014919 ATP binding site [chemical binding]; other site 1245469014920 Q-loop/lid; other site 1245469014921 ABC transporter signature motif; other site 1245469014922 Walker B; other site 1245469014923 D-loop; other site 1245469014924 H-loop/switch region; other site 1245469014925 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469014926 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469014927 Walker A/P-loop; other site 1245469014928 ATP binding site [chemical binding]; other site 1245469014929 Q-loop/lid; other site 1245469014930 ABC transporter signature motif; other site 1245469014931 Walker B; other site 1245469014932 D-loop; other site 1245469014933 H-loop/switch region; other site 1245469014934 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469014935 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469014936 TM-ABC transporter signature motif; other site 1245469014937 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469014938 TM-ABC transporter signature motif; other site 1245469014939 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1245469014940 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 1245469014941 putative ligand binding site [chemical binding]; other site 1245469014942 hypothetical protein; Provisional; Region: PRK05463 1245469014943 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469014944 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469014945 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1245469014946 dimerization interface [polypeptide binding]; other site 1245469014947 allantoate amidohydrolase; Reviewed; Region: PRK09290 1245469014948 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1245469014949 active site 1245469014950 metal binding site [ion binding]; metal-binding site 1245469014951 dimer interface [polypeptide binding]; other site 1245469014952 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1245469014953 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1245469014954 NAD binding site [chemical binding]; other site 1245469014955 tartrate dehydrogenase; Region: TTC; TIGR02089 1245469014956 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1245469014957 short chain dehydrogenase; Provisional; Region: PRK06125 1245469014958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469014959 NAD(P) binding site [chemical binding]; other site 1245469014960 active site 1245469014961 amidase; Provisional; Region: PRK07486 1245469014962 Amidase; Region: Amidase; pfam01425 1245469014963 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1245469014964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469014965 putative substrate translocation pore; other site 1245469014966 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1245469014967 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1245469014968 Moco binding site; other site 1245469014969 metal coordination site [ion binding]; other site 1245469014970 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469014971 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1245469014972 Sulphur transport; Region: Sulf_transp; pfam04143 1245469014973 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469014974 CoenzymeA binding site [chemical binding]; other site 1245469014975 subunit interaction site [polypeptide binding]; other site 1245469014976 PHB binding site; other site 1245469014977 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469014978 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1245469014979 acyl-activating enzyme (AAE) consensus motif; other site 1245469014980 AMP binding site [chemical binding]; other site 1245469014981 active site 1245469014982 CoA binding site [chemical binding]; other site 1245469014983 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1245469014984 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1245469014985 FAD binding pocket [chemical binding]; other site 1245469014986 FAD binding motif [chemical binding]; other site 1245469014987 phosphate binding motif [ion binding]; other site 1245469014988 beta-alpha-beta structure motif; other site 1245469014989 NAD(p) ribose binding residues [chemical binding]; other site 1245469014990 NAD binding pocket [chemical binding]; other site 1245469014991 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1245469014992 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469014993 catalytic loop [active] 1245469014994 iron binding site [ion binding]; other site 1245469014995 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1245469014996 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1245469014997 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1245469014998 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1245469014999 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1245469015000 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1245469015001 PaaX-like protein; Region: PaaX; pfam07848 1245469015002 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1245469015003 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1245469015004 Phasin protein; Region: Phasin_2; cl11491 1245469015005 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1245469015006 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469015007 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469015008 TAP-like protein; Region: Abhydrolase_4; pfam08386 1245469015009 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469015010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469015011 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469015012 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1245469015013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469015014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015015 dimer interface [polypeptide binding]; other site 1245469015016 conserved gate region; other site 1245469015017 putative PBP binding loops; other site 1245469015018 ABC-ATPase subunit interface; other site 1245469015019 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469015020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015021 dimer interface [polypeptide binding]; other site 1245469015022 conserved gate region; other site 1245469015023 putative PBP binding loops; other site 1245469015024 ABC-ATPase subunit interface; other site 1245469015025 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469015026 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469015027 Walker A/P-loop; other site 1245469015028 ATP binding site [chemical binding]; other site 1245469015029 Q-loop/lid; other site 1245469015030 ABC transporter signature motif; other site 1245469015031 Walker B; other site 1245469015032 D-loop; other site 1245469015033 H-loop/switch region; other site 1245469015034 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1245469015035 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1245469015036 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469015037 Walker A/P-loop; other site 1245469015038 ATP binding site [chemical binding]; other site 1245469015039 Q-loop/lid; other site 1245469015040 ABC transporter signature motif; other site 1245469015041 Walker B; other site 1245469015042 D-loop; other site 1245469015043 H-loop/switch region; other site 1245469015044 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469015045 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1245469015046 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1245469015047 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1245469015048 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1245469015049 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469015050 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 1245469015051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469015052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015053 dimer interface [polypeptide binding]; other site 1245469015054 conserved gate region; other site 1245469015055 putative PBP binding loops; other site 1245469015056 ABC-ATPase subunit interface; other site 1245469015057 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469015058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015059 dimer interface [polypeptide binding]; other site 1245469015060 conserved gate region; other site 1245469015061 putative PBP binding loops; other site 1245469015062 ABC-ATPase subunit interface; other site 1245469015063 multidrug efflux protein; Reviewed; Region: PRK09579 1245469015064 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469015065 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469015066 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469015067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469015068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469015069 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469015070 Cytochrome P450; Region: p450; cl12078 1245469015071 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1245469015072 NAD(P) binding site [chemical binding]; other site 1245469015073 putative active site [active] 1245469015074 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1245469015075 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469015076 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1245469015077 active site 1245469015078 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1245469015079 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1245469015080 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1245469015081 NAD(P) binding site [chemical binding]; other site 1245469015082 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1245469015083 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1245469015084 substrate binding site [chemical binding]; other site 1245469015085 ATP binding site [chemical binding]; other site 1245469015086 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1245469015087 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1245469015088 substrate binding site [chemical binding]; other site 1245469015089 dimer interface [polypeptide binding]; other site 1245469015090 ATP binding site [chemical binding]; other site 1245469015091 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1245469015092 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469015093 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469015094 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469015095 substrate binding site [chemical binding]; other site 1245469015096 oxyanion hole (OAH) forming residues; other site 1245469015097 trimer interface [polypeptide binding]; other site 1245469015098 DctM-like transporters; Region: DctM; pfam06808 1245469015099 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469015100 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1245469015101 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469015102 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469015103 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1245469015104 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1245469015105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469015106 NAD(P) binding site [chemical binding]; other site 1245469015107 active site 1245469015108 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1245469015109 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1245469015110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469015111 NAD binding site [chemical binding]; other site 1245469015112 catalytic residues [active] 1245469015113 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1245469015114 TPP-binding site [chemical binding]; other site 1245469015115 PYR/PP interface [polypeptide binding]; other site 1245469015116 dimer interface [polypeptide binding]; other site 1245469015117 TPP binding site [chemical binding]; other site 1245469015118 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 1245469015119 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469015120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469015121 putative DNA binding site [nucleotide binding]; other site 1245469015122 putative Zn2+ binding site [ion binding]; other site 1245469015123 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469015124 ferredoxin-type protein NapF; Region: napF; TIGR00402 1245469015125 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469015126 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1245469015127 catalytic loop [active] 1245469015128 iron binding site [ion binding]; other site 1245469015129 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1245469015130 FAD binding pocket [chemical binding]; other site 1245469015131 FAD binding motif [chemical binding]; other site 1245469015132 phosphate binding motif [ion binding]; other site 1245469015133 beta-alpha-beta structure motif; other site 1245469015134 NAD binding pocket [chemical binding]; other site 1245469015135 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 1245469015136 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469015137 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469015138 EamA-like transporter family; Region: EamA; pfam00892 1245469015139 EamA-like transporter family; Region: EamA; pfam00892 1245469015140 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469015141 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469015142 active site 1245469015143 catalytic tetrad [active] 1245469015144 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1245469015145 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1245469015146 [4Fe-4S] binding site [ion binding]; other site 1245469015147 molybdopterin cofactor binding site; other site 1245469015148 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1245469015149 molybdopterin cofactor binding site; other site 1245469015150 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1245469015151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1245469015152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469015153 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1245469015154 heme-binding site [chemical binding]; other site 1245469015155 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469015156 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469015157 Walker A/P-loop; other site 1245469015158 ATP binding site [chemical binding]; other site 1245469015159 Q-loop/lid; other site 1245469015160 ABC transporter signature motif; other site 1245469015161 Walker B; other site 1245469015162 D-loop; other site 1245469015163 H-loop/switch region; other site 1245469015164 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469015165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015166 putative PBP binding loops; other site 1245469015167 dimer interface [polypeptide binding]; other site 1245469015168 ABC-ATPase subunit interface; other site 1245469015169 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469015170 NMT1-like family; Region: NMT1_2; pfam13379 1245469015171 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1245469015172 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1245469015173 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1245469015174 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1245469015175 active site 1245469015176 ATP binding site [chemical binding]; other site 1245469015177 substrate binding site [chemical binding]; other site 1245469015178 activation loop (A-loop); other site 1245469015179 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 1245469015180 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 1245469015181 dimer interface [polypeptide binding]; other site 1245469015182 active site 1245469015183 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469015184 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469015185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469015186 HWE histidine kinase; Region: HWE_HK; pfam07536 1245469015187 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1245469015188 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1245469015189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469015190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469015191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469015192 dimerization interface [polypeptide binding]; other site 1245469015193 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469015194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469015195 non-specific DNA binding site [nucleotide binding]; other site 1245469015196 salt bridge; other site 1245469015197 sequence-specific DNA binding site [nucleotide binding]; other site 1245469015198 enoyl-CoA hydratase; Provisional; Region: PRK06127 1245469015199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469015200 substrate binding site [chemical binding]; other site 1245469015201 oxyanion hole (OAH) forming residues; other site 1245469015202 trimer interface [polypeptide binding]; other site 1245469015203 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1245469015204 tartrate dehydrogenase; Region: TTC; TIGR02089 1245469015205 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 1245469015206 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1245469015207 putative NAD(P) binding site [chemical binding]; other site 1245469015208 catalytic Zn binding site [ion binding]; other site 1245469015209 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1245469015210 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1245469015211 glycogen synthase; Provisional; Region: glgA; PRK00654 1245469015212 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1245469015213 ADP-binding pocket [chemical binding]; other site 1245469015214 homodimer interface [polypeptide binding]; other site 1245469015215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469015216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469015217 dimer interface [polypeptide binding]; other site 1245469015218 putative CheW interface [polypeptide binding]; other site 1245469015219 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1245469015220 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1245469015221 nucleophile elbow; other site 1245469015222 Patatin phospholipase; Region: DUF3734; pfam12536 1245469015223 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 1245469015224 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1245469015225 metal-binding site [ion binding] 1245469015226 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1245469015227 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1245469015228 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1245469015229 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 1245469015230 FixH; Region: FixH; pfam05751 1245469015231 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1245469015232 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1245469015233 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1245469015234 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1245469015235 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1245469015236 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469015237 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 1245469015238 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 1245469015239 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 1245469015240 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1245469015241 Low-spin heme binding site [chemical binding]; other site 1245469015242 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1245469015243 Putative water exit pathway; other site 1245469015244 Binuclear center (active site) [active] 1245469015245 Putative proton exit pathway; other site 1245469015246 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1245469015247 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1245469015248 Ligand Binding Site [chemical binding]; other site 1245469015249 PAS fold; Region: PAS; pfam00989 1245469015250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469015251 putative active site [active] 1245469015252 heme pocket [chemical binding]; other site 1245469015253 PAS domain S-box; Region: sensory_box; TIGR00229 1245469015254 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469015255 putative active site [active] 1245469015256 heme pocket [chemical binding]; other site 1245469015257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469015258 dimer interface [polypeptide binding]; other site 1245469015259 phosphorylation site [posttranslational modification] 1245469015260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469015261 ATP binding site [chemical binding]; other site 1245469015262 Mg2+ binding site [ion binding]; other site 1245469015263 G-X-G motif; other site 1245469015264 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1245469015265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469015266 active site 1245469015267 phosphorylation site [posttranslational modification] 1245469015268 intermolecular recognition site; other site 1245469015269 dimerization interface [polypeptide binding]; other site 1245469015270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469015271 DNA binding residues [nucleotide binding] 1245469015272 dimerization interface [polypeptide binding]; other site 1245469015273 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469015274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469015275 active site 1245469015276 phosphorylation site [posttranslational modification] 1245469015277 intermolecular recognition site; other site 1245469015278 dimerization interface [polypeptide binding]; other site 1245469015279 transcriptional regulator FixK; Provisional; Region: fixK; PRK09391 1245469015280 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469015281 ligand binding site [chemical binding]; other site 1245469015282 flexible hinge region; other site 1245469015283 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1245469015284 putative switch regulator; other site 1245469015285 non-specific DNA interactions [nucleotide binding]; other site 1245469015286 DNA binding site [nucleotide binding] 1245469015287 sequence specific DNA binding site [nucleotide binding]; other site 1245469015288 putative cAMP binding site [chemical binding]; other site 1245469015289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469015290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469015291 PRC-barrel domain; Region: PRC; pfam05239 1245469015292 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 1245469015293 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1245469015294 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1245469015295 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469015296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469015297 Walker A/P-loop; other site 1245469015298 ATP binding site [chemical binding]; other site 1245469015299 Q-loop/lid; other site 1245469015300 ABC transporter signature motif; other site 1245469015301 Walker B; other site 1245469015302 D-loop; other site 1245469015303 H-loop/switch region; other site 1245469015304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469015305 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1245469015306 putative ADP-binding pocket [chemical binding]; other site 1245469015307 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1245469015308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469015309 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1245469015310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469015311 inhibitor-cofactor binding pocket; inhibition site 1245469015312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469015313 catalytic residue [active] 1245469015314 AAA domain; Region: AAA_26; pfam13500 1245469015315 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1245469015316 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1245469015317 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1245469015318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469015319 catalytic residue [active] 1245469015320 biotin synthase; Region: bioB; TIGR00433 1245469015321 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469015322 FeS/SAM binding site; other site 1245469015323 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1245469015324 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469015325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469015326 DNA-binding site [nucleotide binding]; DNA binding site 1245469015327 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1245469015328 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1245469015329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469015330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469015331 putative substrate translocation pore; other site 1245469015332 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469015333 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469015334 catalytic loop [active] 1245469015335 iron binding site [ion binding]; other site 1245469015336 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469015337 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469015338 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469015339 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469015340 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469015341 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469015342 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1245469015343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469015344 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 1245469015345 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 1245469015346 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469015347 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 1245469015348 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 1245469015349 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 1245469015350 Cytochrome c [Energy production and conversion]; Region: COG3258 1245469015351 Cytochrome c [Energy production and conversion]; Region: COG3258 1245469015352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469015353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469015354 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469015355 putative effector binding pocket; other site 1245469015356 dimerization interface [polypeptide binding]; other site 1245469015357 DoxX-like family; Region: DoxX_2; pfam13564 1245469015358 DsrE/DsrF-like family; Region: DrsE; cl00672 1245469015359 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1245469015360 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1245469015361 catalytic residues [active] 1245469015362 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1245469015363 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469015364 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1245469015365 catalytic triad [active] 1245469015366 conserved cis-peptide bond; other site 1245469015367 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1245469015368 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1245469015369 protein binding site [polypeptide binding]; other site 1245469015370 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469015371 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469015372 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469015373 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1245469015374 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469015375 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1245469015376 Staphylococcal nuclease homologues; Region: SNc; smart00318 1245469015377 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1245469015378 Catalytic site; other site 1245469015379 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1245469015380 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1245469015381 Subunit I/III interface [polypeptide binding]; other site 1245469015382 Subunit III/IV interface [polypeptide binding]; other site 1245469015383 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1245469015384 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1245469015385 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1245469015386 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1245469015387 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1245469015388 Cl- selectivity filter; other site 1245469015389 Cl- binding residues [ion binding]; other site 1245469015390 pore gating glutamate residue; other site 1245469015391 dimer interface [polypeptide binding]; other site 1245469015392 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469015393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 1245469015394 acetyl-CoA acetyltransferase; Provisional; Region: PRK06025 1245469015395 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469015396 dimer interface [polypeptide binding]; other site 1245469015397 active site 1245469015398 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1245469015399 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469015400 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1245469015401 active site 1245469015402 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1245469015403 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469015404 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1245469015405 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469015406 substrate binding pocket [chemical binding]; other site 1245469015407 membrane-bound complex binding site; other site 1245469015408 hinge residues; other site 1245469015409 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1245469015410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469015411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469015412 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1245469015413 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1245469015414 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469015415 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469015416 multidrug efflux protein; Reviewed; Region: PRK09579 1245469015417 Predicted transcriptional regulators [Transcription]; Region: COG1695 1245469015418 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1245469015419 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 1245469015420 The B subunit of unknown Class III extradiol dioxygenases with similarity to Protocatechuate 4,5-dioxygenase; Region: PCA_45_Doxase_B_like_1; cd07949 1245469015421 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1245469015422 putative active site [active] 1245469015423 Fe(II) binding site [ion binding]; other site 1245469015424 putative dimer interface [polypeptide binding]; other site 1245469015425 putative tetramer interface [polypeptide binding]; other site 1245469015426 The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925 1245469015427 putative dimer interface [polypeptide binding]; other site 1245469015428 putative tetramer interface [polypeptide binding]; other site 1245469015429 putative active site [active] 1245469015430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469015431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469015432 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1245469015433 substrate binding pocket [chemical binding]; other site 1245469015434 dimerization interface [polypeptide binding]; other site 1245469015435 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1245469015436 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1245469015437 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469015438 RibD C-terminal domain; Region: RibD_C; cl17279 1245469015439 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1245469015440 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469015441 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469015442 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1245469015443 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469015444 CoenzymeA binding site [chemical binding]; other site 1245469015445 subunit interaction site [polypeptide binding]; other site 1245469015446 PHB binding site; other site 1245469015447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469015448 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1245469015449 CoenzymeA binding site [chemical binding]; other site 1245469015450 subunit interaction site [polypeptide binding]; other site 1245469015451 PHB binding site; other site 1245469015452 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1245469015453 hypothetical protein; Provisional; Region: PRK12472 1245469015454 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469015455 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1245469015456 active site 2 [active] 1245469015457 dimer interface [polypeptide binding]; other site 1245469015458 active site 1 [active] 1245469015459 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469015460 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469015461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469015462 Coenzyme A binding pocket [chemical binding]; other site 1245469015463 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1245469015464 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469015465 ligand binding site [chemical binding]; other site 1245469015466 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469015467 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469015468 TM-ABC transporter signature motif; other site 1245469015469 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469015470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469015471 Walker A/P-loop; other site 1245469015472 ATP binding site [chemical binding]; other site 1245469015473 Q-loop/lid; other site 1245469015474 ABC transporter signature motif; other site 1245469015475 Walker B; other site 1245469015476 D-loop; other site 1245469015477 H-loop/switch region; other site 1245469015478 xylose isomerase; Provisional; Region: PRK05474 1245469015479 xylose isomerase; Region: xylose_isom_A; TIGR02630 1245469015480 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1245469015481 N- and C-terminal domain interface [polypeptide binding]; other site 1245469015482 D-xylulose kinase; Region: XylB; TIGR01312 1245469015483 active site 1245469015484 MgATP binding site [chemical binding]; other site 1245469015485 catalytic site [active] 1245469015486 metal binding site [ion binding]; metal-binding site 1245469015487 xylulose binding site [chemical binding]; other site 1245469015488 homodimer interface [polypeptide binding]; other site 1245469015489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1245469015490 DNA binding site [nucleotide binding] 1245469015491 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1245469015492 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469015493 putative ligand binding site [chemical binding]; other site 1245469015494 PAN domain; Region: PAN_4; pfam14295 1245469015495 putative binding site; other site 1245469015496 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469015497 GAF domain; Region: GAF; pfam01590 1245469015498 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469015499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469015500 metal binding site [ion binding]; metal-binding site 1245469015501 active site 1245469015502 I-site; other site 1245469015503 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1245469015504 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1245469015505 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469015506 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469015507 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1245469015508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469015509 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469015510 Cytochrome P450; Region: p450; cl12078 1245469015511 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1245469015512 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1245469015513 putative active site [active] 1245469015514 putative FMN binding site [chemical binding]; other site 1245469015515 putative substrate binding site [chemical binding]; other site 1245469015516 putative catalytic residue [active] 1245469015517 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469015518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469015519 dimerization interface [polypeptide binding]; other site 1245469015520 putative DNA binding site [nucleotide binding]; other site 1245469015521 putative Zn2+ binding site [ion binding]; other site 1245469015522 AMP nucleosidase; Provisional; Region: PRK08292 1245469015523 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1245469015524 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1245469015525 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1245469015526 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1245469015527 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1245469015528 shikimate binding site; other site 1245469015529 NAD(P) binding site [chemical binding]; other site 1245469015530 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469015531 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469015532 active site 1245469015533 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469015534 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1245469015535 ligand binding site [chemical binding]; other site 1245469015536 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1245469015537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469015538 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 1245469015539 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1245469015540 active site 1245469015541 Fe(II) binding site [ion binding]; other site 1245469015542 dimer interface [polypeptide binding]; other site 1245469015543 tetramer interface [polypeptide binding]; other site 1245469015544 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 1245469015545 tetramer interface [polypeptide binding]; other site 1245469015546 dimer interface [polypeptide binding]; other site 1245469015547 active site 1245469015548 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469015549 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 1245469015550 active site 1245469015551 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469015552 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 1245469015553 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1245469015554 hypothetical protein; Provisional; Region: PRK09262 1245469015555 Amidohydrolase; Region: Amidohydro_2; pfam04909 1245469015556 benzoate transport; Region: 2A0115; TIGR00895 1245469015557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469015558 putative substrate translocation pore; other site 1245469015559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469015560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469015561 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1245469015562 putative dimerization interface [polypeptide binding]; other site 1245469015563 TspO/MBR family; Region: TspO_MBR; pfam03073 1245469015564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469015565 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1245469015566 Walker A motif; other site 1245469015567 ATP binding site [chemical binding]; other site 1245469015568 Walker B motif; other site 1245469015569 arginine finger; other site 1245469015570 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1245469015571 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1245469015572 homotrimer interaction site [polypeptide binding]; other site 1245469015573 putative active site [active] 1245469015574 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469015575 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1245469015576 acyl-activating enzyme (AAE) consensus motif; other site 1245469015577 AMP binding site [chemical binding]; other site 1245469015578 active site 1245469015579 CoA binding site [chemical binding]; other site 1245469015580 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469015581 MarR family; Region: MarR; pfam01047 1245469015582 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469015583 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 1245469015584 putative ligand binding site [chemical binding]; other site 1245469015585 Cupin domain; Region: Cupin_2; pfam07883 1245469015586 hypothetical protein; Provisional; Region: PRK07538 1245469015587 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469015588 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1245469015589 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1245469015590 hypothetical protein; Provisional; Region: PRK07236 1245469015591 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1245469015592 active site 1245469015593 FMN binding site [chemical binding]; other site 1245469015594 substrate binding site [chemical binding]; other site 1245469015595 homotetramer interface [polypeptide binding]; other site 1245469015596 catalytic residue [active] 1245469015597 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469015598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469015599 substrate binding site [chemical binding]; other site 1245469015600 oxyanion hole (OAH) forming residues; other site 1245469015601 trimer interface [polypeptide binding]; other site 1245469015602 classical (c) SDRs; Region: SDR_c; cd05233 1245469015603 NAD(P) binding site [chemical binding]; other site 1245469015604 active site 1245469015605 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469015606 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1245469015607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469015608 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1245469015609 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1245469015610 active site 1245469015611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469015612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1245469015613 acyl-activating enzyme (AAE) consensus motif; other site 1245469015614 AMP binding site [chemical binding]; other site 1245469015615 active site 1245469015616 CoA binding site [chemical binding]; other site 1245469015617 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1245469015618 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 1245469015619 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469015620 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 1245469015621 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469015622 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1245469015623 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469015624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469015625 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469015626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015627 dimer interface [polypeptide binding]; other site 1245469015628 conserved gate region; other site 1245469015629 putative PBP binding loops; other site 1245469015630 ABC-ATPase subunit interface; other site 1245469015631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469015632 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469015633 Walker A/P-loop; other site 1245469015634 ATP binding site [chemical binding]; other site 1245469015635 Q-loop/lid; other site 1245469015636 ABC transporter signature motif; other site 1245469015637 Walker B; other site 1245469015638 D-loop; other site 1245469015639 H-loop/switch region; other site 1245469015640 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1245469015641 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469015642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469015643 substrate binding pocket [chemical binding]; other site 1245469015644 membrane-bound complex binding site; other site 1245469015645 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1245469015646 homotrimer interaction site [polypeptide binding]; other site 1245469015647 putative active site [active] 1245469015648 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469015649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469015650 active site 1245469015651 phosphorylation site [posttranslational modification] 1245469015652 intermolecular recognition site; other site 1245469015653 dimerization interface [polypeptide binding]; other site 1245469015654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469015655 Walker A motif; other site 1245469015656 ATP binding site [chemical binding]; other site 1245469015657 Walker B motif; other site 1245469015658 arginine finger; other site 1245469015659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469015660 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1245469015661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469015662 dimer interface [polypeptide binding]; other site 1245469015663 phosphorylation site [posttranslational modification] 1245469015664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469015665 ATP binding site [chemical binding]; other site 1245469015666 Mg2+ binding site [ion binding]; other site 1245469015667 G-X-G motif; other site 1245469015668 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1245469015669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469015670 malic enzyme; Reviewed; Region: PRK12862 1245469015671 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1245469015672 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1245469015673 putative NAD(P) binding site [chemical binding]; other site 1245469015674 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1245469015675 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1245469015676 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469015677 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469015678 E3 interaction surface; other site 1245469015679 lipoyl attachment site [posttranslational modification]; other site 1245469015680 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1245469015681 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469015682 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469015683 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1245469015684 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1245469015685 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469015686 E3 interaction surface; other site 1245469015687 lipoyl attachment site [posttranslational modification]; other site 1245469015688 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469015689 E3 interaction surface; other site 1245469015690 lipoyl attachment site [posttranslational modification]; other site 1245469015691 e3 binding domain; Region: E3_binding; pfam02817 1245469015692 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1245469015693 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1245469015694 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1245469015695 dimer interface [polypeptide binding]; other site 1245469015696 TPP-binding site [chemical binding]; other site 1245469015697 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1245469015698 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469015699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1245469015700 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1245469015701 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1245469015702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469015703 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1245469015704 Walker A/P-loop; other site 1245469015705 ATP binding site [chemical binding]; other site 1245469015706 Q-loop/lid; other site 1245469015707 ABC transporter signature motif; other site 1245469015708 Walker B; other site 1245469015709 D-loop; other site 1245469015710 H-loop/switch region; other site 1245469015711 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469015712 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1245469015713 Condensation domain; Region: Condensation; pfam00668 1245469015714 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015715 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469015716 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469015717 acyl-activating enzyme (AAE) consensus motif; other site 1245469015718 AMP binding site [chemical binding]; other site 1245469015719 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015720 Condensation domain; Region: Condensation; pfam00668 1245469015721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015722 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469015723 Condensation domain; Region: Condensation; pfam00668 1245469015724 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015725 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469015726 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469015727 acyl-activating enzyme (AAE) consensus motif; other site 1245469015728 AMP binding site [chemical binding]; other site 1245469015729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015730 Condensation domain; Region: Condensation; pfam00668 1245469015731 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469015732 Condensation domain; Region: Condensation; pfam00668 1245469015733 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1245469015734 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1245469015735 acyl-activating enzyme (AAE) consensus motif; other site 1245469015736 AMP binding site [chemical binding]; other site 1245469015737 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015738 Condensation domain; Region: Condensation; pfam00668 1245469015739 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015740 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469015741 acyl-activating enzyme (AAE) consensus motif; other site 1245469015742 AMP binding site [chemical binding]; other site 1245469015743 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015744 Thioesterase domain; Region: Thioesterase; pfam00975 1245469015745 Condensation domain; Region: Condensation; pfam00668 1245469015746 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015747 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469015748 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469015749 acyl-activating enzyme (AAE) consensus motif; other site 1245469015750 AMP binding site [chemical binding]; other site 1245469015751 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015752 Condensation domain; Region: Condensation; pfam00668 1245469015753 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1245469015754 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1245469015755 acyl-activating enzyme (AAE) consensus motif; other site 1245469015756 AMP binding site [chemical binding]; other site 1245469015757 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015758 acyl-CoA synthetase; Validated; Region: PRK05850 1245469015759 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1245469015760 acyl-activating enzyme (AAE) consensus motif; other site 1245469015761 active site 1245469015762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015763 Condensation domain; Region: Condensation; pfam00668 1245469015764 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015765 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1245469015766 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1245469015767 acyl-activating enzyme (AAE) consensus motif; other site 1245469015768 AMP binding site [chemical binding]; other site 1245469015769 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015770 Condensation domain; Region: Condensation; pfam00668 1245469015771 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1245469015772 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1245469015773 Condensation domain; Region: Condensation; pfam00668 1245469015774 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1245469015775 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1245469015776 acyl-activating enzyme (AAE) consensus motif; other site 1245469015777 AMP binding site [chemical binding]; other site 1245469015778 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1245469015779 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1245469015780 Thioesterase domain; Region: Thioesterase; pfam00975 1245469015781 MbtH-like protein; Region: MbtH; cl01279 1245469015782 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1245469015783 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469015784 N-terminal plug; other site 1245469015785 ligand-binding site [chemical binding]; other site 1245469015786 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1245469015787 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1245469015788 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1245469015789 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1245469015790 active site 1245469015791 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469015792 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1245469015793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469015794 putative NAD(P) binding site [chemical binding]; other site 1245469015795 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469015796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469015797 salt bridge; other site 1245469015798 non-specific DNA binding site [nucleotide binding]; other site 1245469015799 sequence-specific DNA binding site [nucleotide binding]; other site 1245469015800 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1245469015801 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1245469015802 nucleotide binding site [chemical binding]; other site 1245469015803 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1245469015804 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1245469015805 ligand binding site [chemical binding]; other site 1245469015806 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469015807 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469015808 TM-ABC transporter signature motif; other site 1245469015809 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469015810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469015811 TM-ABC transporter signature motif; other site 1245469015812 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469015813 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469015814 Walker A/P-loop; other site 1245469015815 ATP binding site [chemical binding]; other site 1245469015816 Q-loop/lid; other site 1245469015817 ABC transporter signature motif; other site 1245469015818 Walker B; other site 1245469015819 D-loop; other site 1245469015820 H-loop/switch region; other site 1245469015821 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469015822 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1245469015823 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1245469015824 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1245469015825 short chain dehydrogenase; Validated; Region: PRK08324 1245469015826 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1245469015827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469015828 NAD(P) binding site [chemical binding]; other site 1245469015829 active site 1245469015830 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1245469015831 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1245469015832 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469015833 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1245469015834 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469015835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469015836 putative DNA binding site [nucleotide binding]; other site 1245469015837 putative Zn2+ binding site [ion binding]; other site 1245469015838 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469015839 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469015840 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469015841 Walker A/P-loop; other site 1245469015842 ATP binding site [chemical binding]; other site 1245469015843 Q-loop/lid; other site 1245469015844 ABC transporter signature motif; other site 1245469015845 Walker B; other site 1245469015846 D-loop; other site 1245469015847 H-loop/switch region; other site 1245469015848 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469015849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469015850 Walker A/P-loop; other site 1245469015851 ATP binding site [chemical binding]; other site 1245469015852 Q-loop/lid; other site 1245469015853 ABC transporter signature motif; other site 1245469015854 Walker B; other site 1245469015855 D-loop; other site 1245469015856 H-loop/switch region; other site 1245469015857 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469015858 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469015859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015860 dimer interface [polypeptide binding]; other site 1245469015861 conserved gate region; other site 1245469015862 ABC-ATPase subunit interface; other site 1245469015863 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469015864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469015865 dimer interface [polypeptide binding]; other site 1245469015866 conserved gate region; other site 1245469015867 putative PBP binding loops; other site 1245469015868 ABC-ATPase subunit interface; other site 1245469015869 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469015870 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 1245469015871 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1245469015872 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1245469015873 hypothetical protein; Provisional; Region: PRK05965 1245469015874 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469015875 inhibitor-cofactor binding pocket; inhibition site 1245469015876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469015877 catalytic residue [active] 1245469015878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1245469015879 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1245469015880 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 1245469015881 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1245469015882 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1245469015883 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1245469015884 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1245469015885 putative ligand binding site [chemical binding]; other site 1245469015886 NAD binding site [chemical binding]; other site 1245469015887 dimerization interface [polypeptide binding]; other site 1245469015888 catalytic site [active] 1245469015889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1245469015890 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1245469015891 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469015892 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469015893 active site 1245469015894 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1245469015895 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1245469015896 Berberine and berberine like; Region: BBE; pfam08031 1245469015897 HdeA/HdeB family; Region: HdeA; cl05752 1245469015898 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1245469015899 dimanganese center [ion binding]; other site 1245469015900 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1245469015901 dimerization interface [polypeptide binding]; other site 1245469015902 metal binding site [ion binding]; metal-binding site 1245469015903 enoyl-CoA hydratase; Provisional; Region: PRK06688 1245469015904 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469015905 substrate binding site [chemical binding]; other site 1245469015906 oxyanion hole (OAH) forming residues; other site 1245469015907 trimer interface [polypeptide binding]; other site 1245469015908 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1245469015909 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1245469015910 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1245469015911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469015912 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1245469015913 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1245469015914 putative active site [active] 1245469015915 putative metal binding site [ion binding]; other site 1245469015916 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1245469015917 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1245469015918 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1245469015919 putative active site [active] 1245469015920 Zn binding site [ion binding]; other site 1245469015921 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1245469015922 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1245469015923 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1245469015924 TPP-binding site; other site 1245469015925 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1245469015926 PYR/PP interface [polypeptide binding]; other site 1245469015927 dimer interface [polypeptide binding]; other site 1245469015928 TPP binding site [chemical binding]; other site 1245469015929 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1245469015930 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1245469015931 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1245469015932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469015933 RNA binding surface [nucleotide binding]; other site 1245469015934 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1245469015935 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1245469015936 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1245469015937 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1245469015938 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1245469015939 metal ion-dependent adhesion site (MIDAS); other site 1245469015940 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 1245469015941 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469015942 cyclase homology domain; Region: CHD; cd07302 1245469015943 nucleotidyl binding site; other site 1245469015944 metal binding site [ion binding]; metal-binding site 1245469015945 dimer interface [polypeptide binding]; other site 1245469015946 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1245469015947 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1245469015948 Tetramer interface [polypeptide binding]; other site 1245469015949 active site 1245469015950 FMN-binding site [chemical binding]; other site 1245469015951 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1245469015952 catalytic core [active] 1245469015953 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 1245469015954 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1245469015955 NAD binding site [chemical binding]; other site 1245469015956 homotetramer interface [polypeptide binding]; other site 1245469015957 homodimer interface [polypeptide binding]; other site 1245469015958 substrate binding site [chemical binding]; other site 1245469015959 active site 1245469015960 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469015961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469015962 DNA binding residues [nucleotide binding] 1245469015963 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1245469015964 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1245469015965 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1245469015966 HSP70 interaction site [polypeptide binding]; other site 1245469015967 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1245469015968 substrate binding site [polypeptide binding]; other site 1245469015969 dimer interface [polypeptide binding]; other site 1245469015970 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1245469015971 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1245469015972 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1245469015973 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1245469015974 classical (c) SDRs; Region: SDR_c; cd05233 1245469015975 NAD(P) binding site [chemical binding]; other site 1245469015976 active site 1245469015977 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1245469015978 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 1245469015979 Cl binding site [ion binding]; other site 1245469015980 oligomer interface [polypeptide binding]; other site 1245469015981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469015982 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469015983 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 1245469015984 nuclear-egress-membrane-like protein; Provisional; Region: PHA03325 1245469015985 putative acyl-CoA synthetase; Provisional; Region: PRK06018 1245469015986 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1245469015987 dimer interface [polypeptide binding]; other site 1245469015988 acyl-activating enzyme (AAE) consensus motif; other site 1245469015989 putative active site [active] 1245469015990 AMP binding site [chemical binding]; other site 1245469015991 putative CoA binding site [chemical binding]; other site 1245469015992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469015993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469015994 putative substrate translocation pore; other site 1245469015995 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 1245469015996 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469015997 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1245469015998 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469015999 FAD binding site [chemical binding]; other site 1245469016000 substrate binding pocket [chemical binding]; other site 1245469016001 catalytic base [active] 1245469016002 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1245469016003 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1245469016004 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1245469016005 dimerization interface [polypeptide binding]; other site 1245469016006 active site 1245469016007 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1245469016008 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469016009 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469016010 homodimer interface [polypeptide binding]; other site 1245469016011 catalytic residue [active] 1245469016012 dihydroorotase; Provisional; Region: PRK09237 1245469016013 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469016014 active site 1245469016015 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469016016 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469016017 active site 1245469016018 catalytic tetrad [active] 1245469016019 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1245469016020 active site 1245469016021 catalytic residues [active] 1245469016022 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016023 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469016024 TM-ABC transporter signature motif; other site 1245469016025 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469016026 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469016027 Walker A/P-loop; other site 1245469016028 ATP binding site [chemical binding]; other site 1245469016029 Q-loop/lid; other site 1245469016030 ABC transporter signature motif; other site 1245469016031 Walker B; other site 1245469016032 D-loop; other site 1245469016033 H-loop/switch region; other site 1245469016034 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469016035 TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955 1245469016036 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1245469016037 putative ligand binding site [chemical binding]; other site 1245469016038 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1245469016039 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1245469016040 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1245469016041 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1245469016042 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1245469016043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469016044 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1245469016045 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1245469016046 carboxyltransferase (CT) interaction site; other site 1245469016047 biotinylation site [posttranslational modification]; other site 1245469016048 hypothetical protein; Provisional; Region: PRK12569 1245469016049 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469016050 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469016051 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 1245469016052 putative substrate binding pocket [chemical binding]; other site 1245469016053 dimerization interface [polypeptide binding]; other site 1245469016054 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1245469016055 Amidohydrolase; Region: Amidohydro_5; pfam13594 1245469016056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1245469016057 active site 1245469016058 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469016059 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469016060 MarR family; Region: MarR_2; cl17246 1245469016061 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469016062 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469016063 Walker A/P-loop; other site 1245469016064 ATP binding site [chemical binding]; other site 1245469016065 Q-loop/lid; other site 1245469016066 ABC transporter signature motif; other site 1245469016067 Walker B; other site 1245469016068 D-loop; other site 1245469016069 H-loop/switch region; other site 1245469016070 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469016071 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469016072 Walker A/P-loop; other site 1245469016073 ATP binding site [chemical binding]; other site 1245469016074 Q-loop/lid; other site 1245469016075 ABC transporter signature motif; other site 1245469016076 Walker B; other site 1245469016077 D-loop; other site 1245469016078 H-loop/switch region; other site 1245469016079 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469016080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016081 TM-ABC transporter signature motif; other site 1245469016082 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469016083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016084 TM-ABC transporter signature motif; other site 1245469016085 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469016086 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 1245469016087 putative ligand binding site [chemical binding]; other site 1245469016088 Amino acid synthesis; Region: AA_synth; pfam06684 1245469016089 hypothetical protein; Provisional; Region: PRK04334 1245469016090 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469016091 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469016092 catalytic loop [active] 1245469016093 iron binding site [ion binding]; other site 1245469016094 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469016095 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469016096 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469016097 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469016098 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469016099 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469016100 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469016101 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469016102 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1245469016103 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469016104 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469016105 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1245469016106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469016107 dimer interface [polypeptide binding]; other site 1245469016108 conserved gate region; other site 1245469016109 putative PBP binding loops; other site 1245469016110 ABC-ATPase subunit interface; other site 1245469016111 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469016112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469016113 dimer interface [polypeptide binding]; other site 1245469016114 conserved gate region; other site 1245469016115 putative PBP binding loops; other site 1245469016116 ABC-ATPase subunit interface; other site 1245469016117 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1245469016118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469016119 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469016120 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1245469016121 Walker A/P-loop; other site 1245469016122 ATP binding site [chemical binding]; other site 1245469016123 Q-loop/lid; other site 1245469016124 ABC transporter signature motif; other site 1245469016125 Walker B; other site 1245469016126 D-loop; other site 1245469016127 H-loop/switch region; other site 1245469016128 TOBE domain; Region: TOBE_2; pfam08402 1245469016129 AroM protein; Region: AroM; cl17601 1245469016130 Protein of unknown function (DUF917); Region: DUF917; pfam06032 1245469016131 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1245469016132 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1245469016133 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1245469016134 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1245469016135 Isochorismatase family; Region: Isochorismatase; pfam00857 1245469016136 catalytic triad [active] 1245469016137 metal binding site [ion binding]; metal-binding site 1245469016138 conserved cis-peptide bond; other site 1245469016139 aldehyde dehydrogenase family 7 member; Region: PLN02315 1245469016140 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1245469016141 NAD(P) binding site [chemical binding]; other site 1245469016142 catalytic residues [active] 1245469016143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469016144 S-adenosylmethionine binding site [chemical binding]; other site 1245469016145 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1245469016146 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1245469016147 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 1245469016148 serine O-acetyltransferase; Region: cysE; TIGR01172 1245469016149 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1245469016150 trimer interface [polypeptide binding]; other site 1245469016151 active site 1245469016152 substrate binding site [chemical binding]; other site 1245469016153 CoA binding site [chemical binding]; other site 1245469016154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016155 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469016156 putative active site [active] 1245469016157 heme pocket [chemical binding]; other site 1245469016158 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469016159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016160 putative active site [active] 1245469016161 heme pocket [chemical binding]; other site 1245469016162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016163 putative active site [active] 1245469016164 heme pocket [chemical binding]; other site 1245469016165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469016166 dimer interface [polypeptide binding]; other site 1245469016167 putative CheW interface [polypeptide binding]; other site 1245469016168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4312 1245469016169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469016170 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1245469016171 DNA-binding site [nucleotide binding]; DNA binding site 1245469016172 FCD domain; Region: FCD; pfam07729 1245469016173 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1245469016174 DctM-like transporters; Region: DctM; pfam06808 1245469016175 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469016176 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 1245469016177 malonyl-CoA synthase; Validated; Region: PRK07514 1245469016178 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 1245469016179 acyl-activating enzyme (AAE) consensus motif; other site 1245469016180 active site 1245469016181 AMP binding site [chemical binding]; other site 1245469016182 CoA binding site [chemical binding]; other site 1245469016183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469016184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469016185 dimer interface [polypeptide binding]; other site 1245469016186 phosphorylation site [posttranslational modification] 1245469016187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469016188 ATP binding site [chemical binding]; other site 1245469016189 G-X-G motif; other site 1245469016190 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469016191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469016192 active site 1245469016193 phosphorylation site [posttranslational modification] 1245469016194 intermolecular recognition site; other site 1245469016195 dimerization interface [polypeptide binding]; other site 1245469016196 circadian clock protein KaiC; Reviewed; Region: PRK09302 1245469016197 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469016198 Walker A motif; other site 1245469016199 ATP binding site [chemical binding]; other site 1245469016200 Walker B motif; other site 1245469016201 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469016202 Walker A motif; other site 1245469016203 ATP binding site [chemical binding]; other site 1245469016204 Walker B motif; other site 1245469016205 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1245469016206 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 1245469016207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469016208 Coenzyme A binding pocket [chemical binding]; other site 1245469016209 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1245469016210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469016211 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469016212 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1245469016213 HAMP domain; Region: HAMP; pfam00672 1245469016214 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469016215 dimer interface [polypeptide binding]; other site 1245469016216 putative CheW interface [polypeptide binding]; other site 1245469016217 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469016218 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469016219 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469016220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469016221 hypothetical protein; Provisional; Region: PRK06126 1245469016222 hypothetical protein; Provisional; Region: PRK07236 1245469016223 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469016224 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1245469016225 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469016226 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1245469016227 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1245469016228 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1245469016229 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469016230 putative acetyltransferase; Provisional; Region: PRK03624 1245469016231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469016232 Coenzyme A binding pocket [chemical binding]; other site 1245469016233 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1245469016234 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1245469016235 dimer interface [polypeptide binding]; other site 1245469016236 ADP-ribose binding site [chemical binding]; other site 1245469016237 active site 1245469016238 nudix motif; other site 1245469016239 metal binding site [ion binding]; metal-binding site 1245469016240 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1245469016241 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 1245469016242 nudix motif; other site 1245469016243 Protein of unknown function (DUF2385); Region: DUF2385; pfam09539 1245469016244 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1245469016245 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1245469016246 Cupin; Region: Cupin_6; pfam12852 1245469016247 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469016248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469016249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469016250 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1245469016251 FOG: CBS domain [General function prediction only]; Region: COG0517 1245469016252 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1245469016253 dihydroorotase; Validated; Region: PRK09060 1245469016254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469016255 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 1245469016256 active site 1245469016257 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1245469016258 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1245469016259 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1245469016260 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1245469016261 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1245469016262 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1245469016263 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1245469016264 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469016265 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469016266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469016267 dimer interface [polypeptide binding]; other site 1245469016268 putative CheW interface [polypeptide binding]; other site 1245469016269 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469016270 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469016271 dimer interface [polypeptide binding]; other site 1245469016272 putative CheW interface [polypeptide binding]; other site 1245469016273 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1245469016274 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1245469016275 NADP binding site [chemical binding]; other site 1245469016276 dimer interface [polypeptide binding]; other site 1245469016277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469016278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469016279 putative substrate translocation pore; other site 1245469016280 L-aspartate oxidase; Provisional; Region: PRK07512 1245469016281 L-aspartate oxidase; Provisional; Region: PRK06175 1245469016282 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1245469016283 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469016284 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469016285 putative ligand binding site [chemical binding]; other site 1245469016286 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469016287 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1245469016288 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1245469016289 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1245469016290 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1245469016291 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1245469016292 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1245469016293 Protein of unknown function (DUF1236); Region: DUF1236; pfam06823 1245469016294 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1245469016295 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1245469016296 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1245469016297 dimer interface [polypeptide binding]; other site 1245469016298 motif 1; other site 1245469016299 active site 1245469016300 motif 2; other site 1245469016301 motif 3; other site 1245469016302 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1245469016303 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1245469016304 tandem repeat interface [polypeptide binding]; other site 1245469016305 oligomer interface [polypeptide binding]; other site 1245469016306 active site residues [active] 1245469016307 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1245469016308 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1245469016309 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1245469016310 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1245469016311 substrate binding pocket [chemical binding]; other site 1245469016312 chain length determination region; other site 1245469016313 substrate-Mg2+ binding site; other site 1245469016314 catalytic residues [active] 1245469016315 aspartate-rich region 1; other site 1245469016316 active site lid residues [active] 1245469016317 aspartate-rich region 2; other site 1245469016318 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 1245469016319 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1245469016320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1245469016321 binding surface 1245469016322 TPR motif; other site 1245469016323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469016324 binding surface 1245469016325 TPR motif; other site 1245469016326 TPR repeat; Region: TPR_11; pfam13414 1245469016327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469016328 binding surface 1245469016329 TPR motif; other site 1245469016330 TPR repeat; Region: TPR_11; pfam13414 1245469016331 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1245469016332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469016333 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 1245469016334 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1245469016335 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1245469016336 Fe-S cluster binding site [ion binding]; other site 1245469016337 active site 1245469016338 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1245469016339 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1245469016340 RNA/DNA hybrid binding site [nucleotide binding]; other site 1245469016341 active site 1245469016342 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 1245469016343 HAD-superfamily phosphatase, subfamily IIIC; Region: HAD-SF-IIIC; TIGR01681 1245469016344 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1245469016345 B12 binding site [chemical binding]; other site 1245469016346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469016347 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1245469016348 FeS/SAM binding site; other site 1245469016349 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 1245469016350 dimer interaction site [polypeptide binding]; other site 1245469016351 substrate-binding tunnel; other site 1245469016352 active site 1245469016353 catalytic site [active] 1245469016354 substrate binding site [chemical binding]; other site 1245469016355 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1245469016356 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1245469016357 catalytic triad [active] 1245469016358 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1245469016359 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1245469016360 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1245469016361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469016362 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1245469016363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469016364 FeS/SAM binding site; other site 1245469016365 putative phosphoketolase; Provisional; Region: PRK05261 1245469016366 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1245469016367 TPP-binding site; other site 1245469016368 XFP C-terminal domain; Region: XFP_C; pfam09363 1245469016369 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1245469016370 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1245469016371 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1245469016372 active site 1245469016373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469016374 MarR family; Region: MarR; pfam01047 1245469016375 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1245469016376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469016377 Coenzyme A binding pocket [chemical binding]; other site 1245469016378 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1245469016379 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1245469016380 MPT binding site; other site 1245469016381 trimer interface [polypeptide binding]; other site 1245469016382 Predicted metalloprotease [General function prediction only]; Region: COG2321 1245469016383 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1245469016384 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1245469016385 DNA methylase; Region: N6_N4_Mtase; pfam01555 1245469016386 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 1245469016387 GAF domain; Region: GAF; pfam01590 1245469016388 Phytochrome region; Region: PHY; pfam00360 1245469016389 HWE histidine kinase; Region: HWE_HK; pfam07536 1245469016390 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469016391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469016392 active site 1245469016393 phosphorylation site [posttranslational modification] 1245469016394 intermolecular recognition site; other site 1245469016395 dimerization interface [polypeptide binding]; other site 1245469016396 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1245469016397 heme binding pocket [chemical binding]; other site 1245469016398 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1245469016399 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1245469016400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469016401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469016402 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1245469016403 substrate binding pocket [chemical binding]; other site 1245469016404 dimerization interface [polypeptide binding]; other site 1245469016405 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1245469016406 C-terminal domain interface [polypeptide binding]; other site 1245469016407 GSH binding site (G-site) [chemical binding]; other site 1245469016408 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469016409 dimer interface [polypeptide binding]; other site 1245469016410 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1245469016411 dimer interface [polypeptide binding]; other site 1245469016412 N-terminal domain interface [polypeptide binding]; other site 1245469016413 substrate binding pocket (H-site) [chemical binding]; other site 1245469016414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469016415 Cache domain; Region: Cache_1; pfam02743 1245469016416 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469016417 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469016418 metal binding site [ion binding]; metal-binding site 1245469016419 active site 1245469016420 I-site; other site 1245469016421 classical (c) SDRs; Region: SDR_c; cd05233 1245469016422 NAD(P) binding site [chemical binding]; other site 1245469016423 active site 1245469016424 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1245469016425 nucleotide binding site/active site [active] 1245469016426 HIT family signature motif; other site 1245469016427 catalytic residue [active] 1245469016428 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1245469016429 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1245469016430 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1245469016431 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1245469016432 FMN binding site [chemical binding]; other site 1245469016433 substrate binding site [chemical binding]; other site 1245469016434 putative catalytic residue [active] 1245469016435 AAA ATPase domain; Region: AAA_16; pfam13191 1245469016436 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469016437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469016438 DNA binding site [nucleotide binding] 1245469016439 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1245469016440 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1245469016441 minor groove reading motif; other site 1245469016442 helix-hairpin-helix signature motif; other site 1245469016443 substrate binding pocket [chemical binding]; other site 1245469016444 active site 1245469016445 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1245469016446 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1245469016447 DNA binding and oxoG recognition site [nucleotide binding] 1245469016448 Protein of unknown function (DUF721); Region: DUF721; cl02324 1245469016449 Thioredoxin; Region: Thioredoxin_4; pfam13462 1245469016450 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1245469016451 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1245469016452 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1245469016453 Walker A/P-loop; other site 1245469016454 ATP binding site [chemical binding]; other site 1245469016455 Q-loop/lid; other site 1245469016456 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1245469016457 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1245469016458 ABC transporter signature motif; other site 1245469016459 Walker B; other site 1245469016460 D-loop; other site 1245469016461 H-loop/switch region; other site 1245469016462 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1245469016463 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1245469016464 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1245469016465 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1245469016466 Peptidase family M48; Region: Peptidase_M48; cl12018 1245469016467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469016468 active site 1245469016469 anthranilate synthase; Provisional; Region: PRK13566 1245469016470 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1245469016471 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1245469016472 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1245469016473 glutamine binding [chemical binding]; other site 1245469016474 catalytic triad [active] 1245469016475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469016476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469016477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016478 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469016479 putative active site [active] 1245469016480 heme pocket [chemical binding]; other site 1245469016481 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1245469016482 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016483 putative active site [active] 1245469016484 heme pocket [chemical binding]; other site 1245469016485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016486 putative active site [active] 1245469016487 heme pocket [chemical binding]; other site 1245469016488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469016489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469016490 dimer interface [polypeptide binding]; other site 1245469016491 putative CheW interface [polypeptide binding]; other site 1245469016492 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469016493 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469016494 hypothetical protein; Provisional; Region: PRK02237 1245469016495 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1245469016496 cytochrome b; Provisional; Region: CYTB; MTH00156 1245469016497 Qi binding site; other site 1245469016498 intrachain domain interface; other site 1245469016499 interchain domain interface [polypeptide binding]; other site 1245469016500 heme bH binding site [chemical binding]; other site 1245469016501 heme bL binding site [chemical binding]; other site 1245469016502 Qo binding site; other site 1245469016503 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 1245469016504 interchain domain interface [polypeptide binding]; other site 1245469016505 intrachain domain interface; other site 1245469016506 Qi binding site; other site 1245469016507 Qo binding site; other site 1245469016508 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 1245469016509 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 1245469016510 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 1245469016511 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 1245469016512 [2Fe-2S] cluster binding site [ion binding]; other site 1245469016513 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1245469016514 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1245469016515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469016516 FeS/SAM binding site; other site 1245469016517 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1245469016518 active site 1245469016519 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1245469016520 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 1245469016521 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1245469016522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469016523 motif II; other site 1245469016524 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1245469016525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469016526 DNA-binding site [nucleotide binding]; DNA binding site 1245469016527 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1245469016528 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1245469016529 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1245469016530 tetramer interface [polypeptide binding]; other site 1245469016531 active site 1245469016532 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1245469016533 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469016534 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1245469016535 Class II fumarases; Region: Fumarase_classII; cd01362 1245469016536 active site 1245469016537 tetramer interface [polypeptide binding]; other site 1245469016538 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469016539 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469016540 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1245469016541 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469016542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469016543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469016544 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 1245469016545 putative substrate binding pocket [chemical binding]; other site 1245469016546 putative dimerization interface [polypeptide binding]; other site 1245469016547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469016548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469016549 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469016550 putative effector binding pocket; other site 1245469016551 dimerization interface [polypeptide binding]; other site 1245469016552 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 1245469016553 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1245469016554 catalytic residues [active] 1245469016555 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469016556 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1245469016557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469016558 dimerization interface [polypeptide binding]; other site 1245469016559 GAF domain; Region: GAF; cl17456 1245469016560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469016561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469016562 metal binding site [ion binding]; metal-binding site 1245469016563 active site 1245469016564 I-site; other site 1245469016565 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1245469016566 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1245469016567 metal binding triad [ion binding]; metal-binding site 1245469016568 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1245469016569 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1245469016570 putative active site [active] 1245469016571 putative CoA binding site [chemical binding]; other site 1245469016572 nudix motif; other site 1245469016573 metal binding site [ion binding]; metal-binding site 1245469016574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 1245469016575 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1245469016576 MoxR-like ATPases [General function prediction only]; Region: COG0714 1245469016577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469016578 Walker A motif; other site 1245469016579 ATP binding site [chemical binding]; other site 1245469016580 Walker B motif; other site 1245469016581 arginine finger; other site 1245469016582 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1245469016583 Protein of unknown function DUF58; Region: DUF58; pfam01882 1245469016584 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 1245469016585 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1245469016586 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1245469016587 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1245469016588 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1245469016589 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1245469016590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469016591 Coenzyme A binding pocket [chemical binding]; other site 1245469016592 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1245469016593 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1245469016594 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1245469016595 ethanolamine permease; Region: 2A0305; TIGR00908 1245469016596 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1245469016597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469016598 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469016599 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1245469016600 metal binding site [ion binding]; metal-binding site 1245469016601 putative dimer interface [polypeptide binding]; other site 1245469016602 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1245469016603 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1245469016604 Ligand binding site; other site 1245469016605 Putative Catalytic site; other site 1245469016606 DXD motif; other site 1245469016607 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1245469016608 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680 1245469016609 nudix motif; other site 1245469016610 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1245469016611 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469016612 active site 1245469016613 metal binding site [ion binding]; metal-binding site 1245469016614 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1245469016615 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469016616 non-specific DNA binding site [nucleotide binding]; other site 1245469016617 salt bridge; other site 1245469016618 sequence-specific DNA binding site [nucleotide binding]; other site 1245469016619 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1245469016620 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1245469016621 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1245469016622 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 1245469016623 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1245469016624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469016625 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1245469016626 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1245469016627 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1245469016628 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1245469016629 Ligand binding site; other site 1245469016630 DXD motif; other site 1245469016631 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1245469016632 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1245469016633 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1245469016634 NAD binding site [chemical binding]; other site 1245469016635 catalytic Zn binding site [ion binding]; other site 1245469016636 structural Zn binding site [ion binding]; other site 1245469016637 phosphoglucomutase; Validated; Region: PRK07564 1245469016638 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1245469016639 active site 1245469016640 substrate binding site [chemical binding]; other site 1245469016641 metal binding site [ion binding]; metal-binding site 1245469016642 lytic murein transglycosylase; Region: MltB_2; TIGR02283 1245469016643 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1245469016644 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469016645 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1245469016646 active site 1245469016647 metal binding site [ion binding]; metal-binding site 1245469016648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469016649 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1245469016650 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469016651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016652 TM-ABC transporter signature motif; other site 1245469016653 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016654 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469016655 TM-ABC transporter signature motif; other site 1245469016656 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469016657 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469016658 Walker A/P-loop; other site 1245469016659 ATP binding site [chemical binding]; other site 1245469016660 Q-loop/lid; other site 1245469016661 ABC transporter signature motif; other site 1245469016662 Walker B; other site 1245469016663 D-loop; other site 1245469016664 H-loop/switch region; other site 1245469016665 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469016666 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1245469016667 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 1245469016668 putative ligand binding site [chemical binding]; other site 1245469016669 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1245469016670 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1245469016671 FMN binding site [chemical binding]; other site 1245469016672 active site 1245469016673 substrate binding site [chemical binding]; other site 1245469016674 catalytic residue [active] 1245469016675 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469016676 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1245469016677 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1245469016678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469016679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469016680 active site 1245469016681 phosphorylation site [posttranslational modification] 1245469016682 intermolecular recognition site; other site 1245469016683 dimerization interface [polypeptide binding]; other site 1245469016684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469016685 DNA binding residues [nucleotide binding] 1245469016686 dimerization interface [polypeptide binding]; other site 1245469016687 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1245469016688 EF-hand domain pair; Region: EF_hand_5; pfam13499 1245469016689 Ca2+ binding site [ion binding]; other site 1245469016690 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1245469016691 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1245469016692 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1245469016693 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1245469016694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1245469016695 TPR motif; other site 1245469016696 binding surface 1245469016697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469016698 TPR motif; other site 1245469016699 binding surface 1245469016700 TPR repeat; Region: TPR_11; pfam13414 1245469016701 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469016702 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469016703 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 1245469016704 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469016705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469016706 dimer interface [polypeptide binding]; other site 1245469016707 conserved gate region; other site 1245469016708 putative PBP binding loops; other site 1245469016709 ABC-ATPase subunit interface; other site 1245469016710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469016711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469016712 dimer interface [polypeptide binding]; other site 1245469016713 conserved gate region; other site 1245469016714 putative PBP binding loops; other site 1245469016715 ABC-ATPase subunit interface; other site 1245469016716 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469016717 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1245469016718 Walker A/P-loop; other site 1245469016719 ATP binding site [chemical binding]; other site 1245469016720 Q-loop/lid; other site 1245469016721 ABC transporter signature motif; other site 1245469016722 Walker B; other site 1245469016723 D-loop; other site 1245469016724 H-loop/switch region; other site 1245469016725 TOBE domain; Region: TOBE; pfam03459 1245469016726 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1245469016727 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1245469016728 Walker A/P-loop; other site 1245469016729 ATP binding site [chemical binding]; other site 1245469016730 Q-loop/lid; other site 1245469016731 ABC transporter signature motif; other site 1245469016732 Walker B; other site 1245469016733 D-loop; other site 1245469016734 H-loop/switch region; other site 1245469016735 TOBE domain; Region: TOBE; pfam03459 1245469016736 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1245469016737 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1245469016738 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1245469016739 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1245469016740 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1245469016741 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1245469016742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469016743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469016744 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1245469016745 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469016746 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1245469016747 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469016748 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1245469016749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469016750 putative substrate translocation pore; other site 1245469016751 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1245469016752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1245469016753 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1245469016754 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1245469016755 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1245469016756 ligand binding site [chemical binding]; other site 1245469016757 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1245469016758 FecR protein; Region: FecR; pfam04773 1245469016759 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 1245469016760 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1245469016761 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1245469016762 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1245469016763 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469016764 Cupin domain; Region: Cupin_2; cl17218 1245469016765 CsbD-like; Region: CsbD; pfam05532 1245469016766 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1245469016767 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1245469016768 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1245469016769 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1245469016770 rhodanese superfamily protein; Provisional; Region: PRK05320 1245469016771 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1245469016772 active site residue [active] 1245469016773 SlyX; Region: SlyX; pfam04102 1245469016774 Cache domain; Region: Cache_1; pfam02743 1245469016775 PAS domain S-box; Region: sensory_box; TIGR00229 1245469016776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469016777 putative active site [active] 1245469016778 heme pocket [chemical binding]; other site 1245469016779 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469016780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469016781 metal binding site [ion binding]; metal-binding site 1245469016782 active site 1245469016783 I-site; other site 1245469016784 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1245469016785 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1245469016786 substrate binding site [chemical binding]; other site 1245469016787 active site 1245469016788 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1245469016789 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1245469016790 domain interfaces; other site 1245469016791 active site 1245469016792 choline dehydrogenase; Validated; Region: PRK02106 1245469016793 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469016794 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1245469016795 propionate/acetate kinase; Provisional; Region: PRK12379 1245469016796 methionine synthase; Provisional; Region: PRK01207 1245469016797 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1245469016798 substrate binding site [chemical binding]; other site 1245469016799 THF binding site; other site 1245469016800 zinc-binding site [ion binding]; other site 1245469016801 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1245469016802 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1245469016803 FMN-binding pocket [chemical binding]; other site 1245469016804 flavin binding motif; other site 1245469016805 phosphate binding motif [ion binding]; other site 1245469016806 beta-alpha-beta structure motif; other site 1245469016807 NAD binding pocket [chemical binding]; other site 1245469016808 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469016809 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1245469016810 catalytic loop [active] 1245469016811 iron binding site [ion binding]; other site 1245469016812 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1245469016813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469016814 DNA-binding site [nucleotide binding]; DNA binding site 1245469016815 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1245469016816 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1245469016817 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1245469016818 iron-sulfur cluster [ion binding]; other site 1245469016819 [2Fe-2S] cluster binding site [ion binding]; other site 1245469016820 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 1245469016821 alpha subunit interface [polypeptide binding]; other site 1245469016822 active site 1245469016823 substrate binding site [chemical binding]; other site 1245469016824 Fe binding site [ion binding]; other site 1245469016825 SnoaL-like domain; Region: SnoaL_4; pfam13577 1245469016826 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 1245469016827 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1245469016828 dimer interface [polypeptide binding]; other site 1245469016829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469016830 S-adenosylmethionine binding site [chemical binding]; other site 1245469016831 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469016832 HWE histidine kinase; Region: HWE_HK; smart00911 1245469016833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469016834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469016835 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469016836 putative effector binding pocket; other site 1245469016837 dimerization interface [polypeptide binding]; other site 1245469016838 PcfJ-like protein; Region: PcfJ; pfam14284 1245469016839 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1245469016840 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1245469016841 FMN-binding pocket [chemical binding]; other site 1245469016842 flavin binding motif; other site 1245469016843 phosphate binding motif [ion binding]; other site 1245469016844 beta-alpha-beta structure motif; other site 1245469016845 NAD binding pocket [chemical binding]; other site 1245469016846 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469016847 catalytic loop [active] 1245469016848 iron binding site [ion binding]; other site 1245469016849 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1245469016850 NADPH bind site [chemical binding]; other site 1245469016851 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1245469016852 putative FMN binding site [chemical binding]; other site 1245469016853 NADPH bind site [chemical binding]; other site 1245469016854 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1245469016855 active site residue [active] 1245469016856 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1245469016857 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1245469016858 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1245469016859 iron-sulfur cluster [ion binding]; other site 1245469016860 [2Fe-2S] cluster binding site [ion binding]; other site 1245469016861 glutathionine S-transferase; Provisional; Region: PRK10542 1245469016862 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1245469016863 C-terminal domain interface [polypeptide binding]; other site 1245469016864 GSH binding site (G-site) [chemical binding]; other site 1245469016865 dimer interface [polypeptide binding]; other site 1245469016866 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1245469016867 dimer interface [polypeptide binding]; other site 1245469016868 substrate binding pocket (H-site) [chemical binding]; other site 1245469016869 N-terminal domain interface [polypeptide binding]; other site 1245469016870 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1245469016871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469016872 Walker A motif; other site 1245469016873 ATP binding site [chemical binding]; other site 1245469016874 Walker B motif; other site 1245469016875 arginine finger; other site 1245469016876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469016877 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1245469016878 SnoaL-like domain; Region: SnoaL_3; pfam13474 1245469016879 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1245469016880 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1245469016881 active site residue [active] 1245469016882 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 1245469016883 active site residue [active] 1245469016884 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 1245469016885 active site residue [active] 1245469016886 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1245469016887 active site residue [active] 1245469016888 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016889 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1245469016890 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469016891 TM-ABC transporter signature motif; other site 1245469016892 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469016893 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469016894 Walker A/P-loop; other site 1245469016895 ATP binding site [chemical binding]; other site 1245469016896 Q-loop/lid; other site 1245469016897 ABC transporter signature motif; other site 1245469016898 Walker B; other site 1245469016899 D-loop; other site 1245469016900 H-loop/switch region; other site 1245469016901 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469016902 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1245469016903 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1245469016904 putative ligand binding site [chemical binding]; other site 1245469016905 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1245469016906 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1245469016907 active site 1245469016908 catalytic residues [active] 1245469016909 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1245469016910 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469016911 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469016912 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1245469016913 inhibitor site; inhibition site 1245469016914 active site 1245469016915 dimer interface [polypeptide binding]; other site 1245469016916 catalytic residue [active] 1245469016917 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1245469016918 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1245469016919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469016920 DNA-binding site [nucleotide binding]; DNA binding site 1245469016921 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1245469016922 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016923 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469016924 TM-ABC transporter signature motif; other site 1245469016925 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469016926 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1245469016927 TM-ABC transporter signature motif; other site 1245469016928 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1245469016929 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469016930 Walker A/P-loop; other site 1245469016931 ATP binding site [chemical binding]; other site 1245469016932 Q-loop/lid; other site 1245469016933 ABC transporter signature motif; other site 1245469016934 Walker B; other site 1245469016935 D-loop; other site 1245469016936 H-loop/switch region; other site 1245469016937 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469016938 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1245469016939 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469016940 putative ligand binding site [chemical binding]; other site 1245469016941 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1245469016942 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1245469016943 active site 1245469016944 intersubunit interface [polypeptide binding]; other site 1245469016945 catalytic residue [active] 1245469016946 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1245469016947 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1245469016948 substrate binding site [chemical binding]; other site 1245469016949 ATP binding site [chemical binding]; other site 1245469016950 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1245469016951 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1245469016952 putative NAD(P) binding site [chemical binding]; other site 1245469016953 catalytic Zn binding site [ion binding]; other site 1245469016954 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 1245469016955 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1245469016956 NADP binding site [chemical binding]; other site 1245469016957 homodimer interface [polypeptide binding]; other site 1245469016958 active site 1245469016959 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1245469016960 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1245469016961 active site pocket [active] 1245469016962 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469016963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469016964 DNA-binding site [nucleotide binding]; DNA binding site 1245469016965 FCD domain; Region: FCD; pfam07729 1245469016966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469016967 putative substrate translocation pore; other site 1245469016968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469016969 mannonate dehydratase; Region: uxuA; TIGR00695 1245469016970 mannonate dehydratase; Provisional; Region: PRK03906 1245469016971 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469016972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469016973 DNA-binding site [nucleotide binding]; DNA binding site 1245469016974 FCD domain; Region: FCD; pfam07729 1245469016975 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1245469016976 DctM-like transporters; Region: DctM; pfam06808 1245469016977 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469016978 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469016979 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1245469016980 putative oxidoreductase; Provisional; Region: PRK10083 1245469016981 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1245469016982 putative NAD(P) binding site [chemical binding]; other site 1245469016983 catalytic Zn binding site [ion binding]; other site 1245469016984 structural Zn binding site [ion binding]; other site 1245469016985 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1245469016986 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1245469016987 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1245469016988 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469016989 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469016990 Walker A/P-loop; other site 1245469016991 ATP binding site [chemical binding]; other site 1245469016992 Q-loop/lid; other site 1245469016993 ABC transporter signature motif; other site 1245469016994 Walker B; other site 1245469016995 D-loop; other site 1245469016996 H-loop/switch region; other site 1245469016997 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469016998 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469016999 Walker A/P-loop; other site 1245469017000 ATP binding site [chemical binding]; other site 1245469017001 Q-loop/lid; other site 1245469017002 ABC transporter signature motif; other site 1245469017003 Walker B; other site 1245469017004 D-loop; other site 1245469017005 H-loop/switch region; other site 1245469017006 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469017007 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469017008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017009 dimer interface [polypeptide binding]; other site 1245469017010 conserved gate region; other site 1245469017011 putative PBP binding loops; other site 1245469017012 ABC-ATPase subunit interface; other site 1245469017013 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469017014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017015 dimer interface [polypeptide binding]; other site 1245469017016 conserved gate region; other site 1245469017017 putative PBP binding loops; other site 1245469017018 ABC-ATPase subunit interface; other site 1245469017019 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1245469017020 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469017021 Immunoglobulin domain; Region: Ig; cl11960 1245469017022 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1245469017023 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1245469017024 short chain dehydrogenase; Provisional; Region: PRK06138 1245469017025 classical (c) SDRs; Region: SDR_c; cd05233 1245469017026 NAD(P) binding site [chemical binding]; other site 1245469017027 active site 1245469017028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469017029 extended (e) SDRs; Region: SDR_e; cd08946 1245469017030 NAD(P) binding site [chemical binding]; other site 1245469017031 active site 1245469017032 substrate binding site [chemical binding]; other site 1245469017033 dihydropyrimidinase; Provisional; Region: PRK13404 1245469017034 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1245469017035 tetramer interface [polypeptide binding]; other site 1245469017036 active site 1245469017037 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1245469017038 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 1245469017039 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469017040 tetramer interface [polypeptide binding]; other site 1245469017041 active site 1245469017042 catalytic triad [active] 1245469017043 dimer interface [polypeptide binding]; other site 1245469017044 cytosine deaminase; Provisional; Region: PRK05985 1245469017045 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1245469017046 active site 1245469017047 hypothetical protein; Validated; Region: PRK07198 1245469017048 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1245469017049 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1245469017050 dimerization interface [polypeptide binding]; other site 1245469017051 active site 1245469017052 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1245469017053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469017054 active site 1245469017055 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 1245469017056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1245469017057 active site 1245469017058 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469017059 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 1245469017060 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 1245469017061 active site 1245469017062 catalytic site [active] 1245469017063 Zn binding site [ion binding]; other site 1245469017064 tetramer interface [polypeptide binding]; other site 1245469017065 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1245469017066 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469017067 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469017068 substrate binding pocket [chemical binding]; other site 1245469017069 membrane-bound complex binding site; other site 1245469017070 hinge residues; other site 1245469017071 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1245469017072 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1245469017073 Walker A/P-loop; other site 1245469017074 ATP binding site [chemical binding]; other site 1245469017075 Q-loop/lid; other site 1245469017076 ABC transporter signature motif; other site 1245469017077 Walker B; other site 1245469017078 D-loop; other site 1245469017079 H-loop/switch region; other site 1245469017080 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1245469017081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017082 dimer interface [polypeptide binding]; other site 1245469017083 conserved gate region; other site 1245469017084 putative PBP binding loops; other site 1245469017085 ABC-ATPase subunit interface; other site 1245469017086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469017087 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469017088 substrate binding pocket [chemical binding]; other site 1245469017089 membrane-bound complex binding site; other site 1245469017090 hinge residues; other site 1245469017091 N-carbamyl-D-amino acid amidohydrolase (DCase, class 6 nitrilases); Region: DCase; cd07569 1245469017092 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1245469017093 tetramer interface [polypeptide binding]; other site 1245469017094 active site 1245469017095 catalytic triad [active] 1245469017096 dimer interface [polypeptide binding]; other site 1245469017097 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469017098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469017099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469017100 dimerization interface [polypeptide binding]; other site 1245469017101 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1245469017102 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1245469017103 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1245469017104 metal ion-dependent adhesion site (MIDAS); other site 1245469017105 MoxR-like ATPases [General function prediction only]; Region: COG0714 1245469017106 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1245469017107 Walker A motif; other site 1245469017108 ATP binding site [chemical binding]; other site 1245469017109 Walker B motif; other site 1245469017110 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1245469017111 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1245469017112 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1245469017113 D-pathway; other site 1245469017114 K-pathway; other site 1245469017115 Binuclear center (active site) [active] 1245469017116 Putative proton exit pathway; other site 1245469017117 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469017118 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1245469017119 Subunit I/III interface [polypeptide binding]; other site 1245469017120 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1245469017121 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469017122 putative metal binding site [ion binding]; other site 1245469017123 amidase; Provisional; Region: PRK07487 1245469017124 Amidase; Region: Amidase; cl11426 1245469017125 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1245469017126 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469017127 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1245469017128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017129 dimer interface [polypeptide binding]; other site 1245469017130 conserved gate region; other site 1245469017131 putative PBP binding loops; other site 1245469017132 ABC-ATPase subunit interface; other site 1245469017133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469017134 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1245469017135 Walker A/P-loop; other site 1245469017136 ATP binding site [chemical binding]; other site 1245469017137 Q-loop/lid; other site 1245469017138 ABC transporter signature motif; other site 1245469017139 Walker B; other site 1245469017140 D-loop; other site 1245469017141 H-loop/switch region; other site 1245469017142 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1245469017143 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 1245469017144 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1245469017145 TOBE domain; Region: TOBE; cl01440 1245469017146 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1245469017147 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1245469017148 ligand binding site [chemical binding]; other site 1245469017149 NAD binding site [chemical binding]; other site 1245469017150 tetramer interface [polypeptide binding]; other site 1245469017151 catalytic site [active] 1245469017152 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1245469017153 L-serine binding site [chemical binding]; other site 1245469017154 ACT domain interface; other site 1245469017155 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1245469017156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1245469017157 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1245469017158 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1245469017159 substrate binding pocket [chemical binding]; other site 1245469017160 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1245469017161 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1245469017162 active site 1245469017163 intersubunit interface [polypeptide binding]; other site 1245469017164 catalytic residue [active] 1245469017165 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1245469017166 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1245469017167 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1245469017168 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1245469017169 Uncharacterized conserved protein [Function unknown]; Region: COG2155 1245469017170 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1245469017171 Cation efflux family; Region: Cation_efflux; pfam01545 1245469017172 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1245469017173 nucleoside/Zn binding site; other site 1245469017174 dimer interface [polypeptide binding]; other site 1245469017175 catalytic motif [active] 1245469017176 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1245469017177 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1245469017178 Walker A/P-loop; other site 1245469017179 ATP binding site [chemical binding]; other site 1245469017180 Q-loop/lid; other site 1245469017181 ABC transporter signature motif; other site 1245469017182 Walker B; other site 1245469017183 D-loop; other site 1245469017184 H-loop/switch region; other site 1245469017185 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1245469017186 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469017187 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1245469017188 TM-ABC transporter signature motif; other site 1245469017189 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1245469017190 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469017191 TM-ABC transporter signature motif; other site 1245469017192 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1245469017193 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1245469017194 putative ligand binding site [chemical binding]; other site 1245469017195 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469017196 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1245469017197 peptide binding site [polypeptide binding]; other site 1245469017198 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469017199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017200 dimer interface [polypeptide binding]; other site 1245469017201 conserved gate region; other site 1245469017202 putative PBP binding loops; other site 1245469017203 ABC-ATPase subunit interface; other site 1245469017204 dipeptide transporter; Provisional; Region: PRK10913 1245469017205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017206 dimer interface [polypeptide binding]; other site 1245469017207 conserved gate region; other site 1245469017208 putative PBP binding loops; other site 1245469017209 ABC-ATPase subunit interface; other site 1245469017210 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469017211 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469017212 Walker A/P-loop; other site 1245469017213 ATP binding site [chemical binding]; other site 1245469017214 Q-loop/lid; other site 1245469017215 ABC transporter signature motif; other site 1245469017216 Walker B; other site 1245469017217 D-loop; other site 1245469017218 H-loop/switch region; other site 1245469017219 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469017220 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1245469017221 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469017222 Walker A/P-loop; other site 1245469017223 ATP binding site [chemical binding]; other site 1245469017224 Q-loop/lid; other site 1245469017225 ABC transporter signature motif; other site 1245469017226 Walker B; other site 1245469017227 D-loop; other site 1245469017228 H-loop/switch region; other site 1245469017229 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469017230 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1245469017231 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1245469017232 active site 1245469017233 putative substrate binding pocket [chemical binding]; other site 1245469017234 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1245469017235 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469017236 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469017237 catalytic loop [active] 1245469017238 iron binding site [ion binding]; other site 1245469017239 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469017240 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469017241 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469017242 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469017243 xanthine permease; Region: pbuX; TIGR03173 1245469017244 Protein of unknown function (DUF989); Region: DUF989; pfam06181 1245469017245 Predicted membrane protein [Function unknown]; Region: COG3748 1245469017246 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469017247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469017248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469017249 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469017250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469017251 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469017252 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469017253 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469017254 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1245469017255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1245469017256 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1245469017257 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1245469017258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469017259 active site 1245469017260 phosphorylation site [posttranslational modification] 1245469017261 intermolecular recognition site; other site 1245469017262 dimerization interface [polypeptide binding]; other site 1245469017263 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469017264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1245469017265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469017266 dimer interface [polypeptide binding]; other site 1245469017267 phosphorylation site [posttranslational modification] 1245469017268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469017269 ATP binding site [chemical binding]; other site 1245469017270 Mg2+ binding site [ion binding]; other site 1245469017271 G-X-G motif; other site 1245469017272 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1245469017273 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1245469017274 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1245469017275 Subunit I/III interface [polypeptide binding]; other site 1245469017276 Subunit III/IV interface [polypeptide binding]; other site 1245469017277 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1245469017278 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1245469017279 D-pathway; other site 1245469017280 Putative ubiquinol binding site [chemical binding]; other site 1245469017281 Low-spin heme (heme b) binding site [chemical binding]; other site 1245469017282 Putative water exit pathway; other site 1245469017283 Binuclear center (heme o3/CuB) [ion binding]; other site 1245469017284 K-pathway; other site 1245469017285 Putative proton exit pathway; other site 1245469017286 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1245469017287 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1245469017288 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1245469017289 metabolite-proton symporter; Region: 2A0106; TIGR00883 1245469017290 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1245469017291 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469017292 PYR/PP interface [polypeptide binding]; other site 1245469017293 dimer interface [polypeptide binding]; other site 1245469017294 TPP binding site [chemical binding]; other site 1245469017295 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469017296 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1245469017297 TPP-binding site; other site 1245469017298 dimer interface [polypeptide binding]; other site 1245469017299 Membrane transport protein; Region: Mem_trans; cl09117 1245469017300 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1245469017301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469017302 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469017303 acyl-activating enzyme (AAE) consensus motif; other site 1245469017304 acyl-activating enzyme (AAE) consensus motif; other site 1245469017305 putative AMP binding site [chemical binding]; other site 1245469017306 putative active site [active] 1245469017307 putative CoA binding site [chemical binding]; other site 1245469017308 Cytochrome c; Region: Cytochrom_C; cl11414 1245469017309 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 1245469017310 Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277 1245469017311 dimer interface [polypeptide binding]; other site 1245469017312 Trp docking motif [polypeptide binding]; other site 1245469017313 active site 1245469017314 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1245469017315 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469017316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469017317 DNA-binding site [nucleotide binding]; DNA binding site 1245469017318 FCD domain; Region: FCD; pfam07729 1245469017319 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1245469017320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469017321 DNA-binding site [nucleotide binding]; DNA binding site 1245469017322 FCD domain; Region: FCD; pfam07729 1245469017323 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1245469017324 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1245469017325 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469017326 putative active site [active] 1245469017327 heme pocket [chemical binding]; other site 1245469017328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469017329 dimer interface [polypeptide binding]; other site 1245469017330 phosphorylation site [posttranslational modification] 1245469017331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469017332 ATP binding site [chemical binding]; other site 1245469017333 Mg2+ binding site [ion binding]; other site 1245469017334 G-X-G motif; other site 1245469017335 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469017336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469017337 active site 1245469017338 phosphorylation site [posttranslational modification] 1245469017339 intermolecular recognition site; other site 1245469017340 dimerization interface [polypeptide binding]; other site 1245469017341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469017342 Walker A motif; other site 1245469017343 ATP binding site [chemical binding]; other site 1245469017344 Walker B motif; other site 1245469017345 arginine finger; other site 1245469017346 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469017347 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1245469017348 dimerization interface [polypeptide binding]; other site 1245469017349 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1245469017350 ATP binding site [chemical binding]; other site 1245469017351 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1245469017352 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1245469017353 HupF/HypC family; Region: HupF_HypC; pfam01455 1245469017354 Acylphosphatase; Region: Acylphosphatase; pfam00708 1245469017355 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1245469017356 HypF finger; Region: zf-HYPF; pfam07503 1245469017357 HypF finger; Region: zf-HYPF; pfam07503 1245469017358 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1245469017359 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469017360 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1245469017361 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1245469017362 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1245469017363 Protein of unknown function (DUF3457); Region: DUF3457; pfam11939 1245469017364 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1245469017365 Rubredoxin; Region: Rubredoxin; pfam00301 1245469017366 iron binding site [ion binding]; other site 1245469017367 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1245469017368 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1245469017369 HupF/HypC family; Region: HupF_HypC; pfam01455 1245469017370 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1245469017371 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1245469017372 putative substrate-binding site; other site 1245469017373 nickel binding site [ion binding]; other site 1245469017374 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1245469017375 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1245469017376 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1245469017377 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1245469017378 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1245469017379 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1245469017380 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1245469017381 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1245469017382 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1245469017383 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1245469017384 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1245469017385 High-affinity nickel-transport protein; Region: NicO; cl00964 1245469017386 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469017387 Sel1-like repeats; Region: SEL1; smart00671 1245469017388 Sel1-like repeats; Region: SEL1; smart00671 1245469017389 Sel1-like repeats; Region: SEL1; smart00671 1245469017390 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1245469017391 active site 1245469017392 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1245469017393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469017394 active site 1245469017395 phosphorylation site [posttranslational modification] 1245469017396 intermolecular recognition site; other site 1245469017397 dimerization interface [polypeptide binding]; other site 1245469017398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469017399 DNA binding site [nucleotide binding] 1245469017400 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1245469017401 PhoU domain; Region: PhoU; pfam01895 1245469017402 PhoU domain; Region: PhoU; pfam01895 1245469017403 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1245469017404 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1245469017405 Walker A/P-loop; other site 1245469017406 ATP binding site [chemical binding]; other site 1245469017407 Q-loop/lid; other site 1245469017408 ABC transporter signature motif; other site 1245469017409 Walker B; other site 1245469017410 D-loop; other site 1245469017411 H-loop/switch region; other site 1245469017412 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1245469017413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017414 dimer interface [polypeptide binding]; other site 1245469017415 conserved gate region; other site 1245469017416 putative PBP binding loops; other site 1245469017417 ABC-ATPase subunit interface; other site 1245469017418 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1245469017419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017420 dimer interface [polypeptide binding]; other site 1245469017421 conserved gate region; other site 1245469017422 putative PBP binding loops; other site 1245469017423 ABC-ATPase subunit interface; other site 1245469017424 PBP superfamily domain; Region: PBP_like_2; cl17296 1245469017425 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1245469017426 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469017427 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1245469017428 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1245469017429 dimerization interface [polypeptide binding]; other site 1245469017430 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1245469017431 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1245469017432 dimer interface [polypeptide binding]; other site 1245469017433 active site 1245469017434 heme binding site [chemical binding]; other site 1245469017435 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1245469017436 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1245469017437 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1245469017438 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1245469017439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469017440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469017441 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1245469017442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469017443 motif II; other site 1245469017444 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 1245469017445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469017446 Walker A motif; other site 1245469017447 ATP binding site [chemical binding]; other site 1245469017448 Walker B motif; other site 1245469017449 arginine finger; other site 1245469017450 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 1245469017451 multimerization interface [polypeptide binding]; other site 1245469017452 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 1245469017453 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 1245469017454 homodimer interface [polypeptide binding]; other site 1245469017455 active site 1245469017456 heterodimer interface [polypeptide binding]; other site 1245469017457 catalytic residue [active] 1245469017458 metal binding site [ion binding]; metal-binding site 1245469017459 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1245469017460 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1245469017461 intersubunit interface [polypeptide binding]; other site 1245469017462 active site 1245469017463 zinc binding site [ion binding]; other site 1245469017464 Na+ binding site [ion binding]; other site 1245469017465 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1245469017466 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1245469017467 TPP-binding site [chemical binding]; other site 1245469017468 dimer interface [polypeptide binding]; other site 1245469017469 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1245469017470 PYR/PP interface [polypeptide binding]; other site 1245469017471 dimer interface [polypeptide binding]; other site 1245469017472 TPP binding site [chemical binding]; other site 1245469017473 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1245469017474 phosphoribulokinase; Provisional; Region: PRK15453 1245469017475 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1245469017476 metal binding site [ion binding]; metal-binding site 1245469017477 active site 1245469017478 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469017479 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469017480 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 1245469017481 putative dimerization interface [polypeptide binding]; other site 1245469017482 V4R domain; Region: V4R; cl15268 1245469017483 magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026 1245469017484 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1245469017485 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469017486 FeS/SAM binding site; other site 1245469017487 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1245469017488 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1245469017489 substrate-cofactor binding pocket; other site 1245469017490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469017491 catalytic residue [active] 1245469017492 Protein of unknown function (DUF3623); Region: DUF3623; pfam12291 1245469017493 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 1245469017494 diiron binding motif [ion binding]; other site 1245469017495 putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054 1245469017496 photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150 1245469017497 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581 1245469017498 subunit M interaction residues [polypeptide binding]; other site 1245469017499 subunit L interaction residues [polypeptide binding]; other site 1245469017500 putative proton transfer pathway, P1; other site 1245469017501 putative proton transfer pathway, P2; other site 1245469017502 PUCC protein; Region: PUCC; pfam03209 1245469017503 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 1245469017504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469017505 S-adenosylmethionine binding site [chemical binding]; other site 1245469017506 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 1245469017507 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 1245469017508 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 1245469017509 P-loop; other site 1245469017510 magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405 1245469017511 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 1245469017512 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1245469017513 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 1245469017514 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 1245469017515 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1245469017516 light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842 1245469017517 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 1245469017518 2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284 1245469017519 B12 binding domain; Region: B12-binding_2; pfam02607 1245469017520 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 1245469017521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469017522 putative active site [active] 1245469017523 heme pocket [chemical binding]; other site 1245469017524 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469017525 bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566 1245469017526 UbiA prenyltransferase family; Region: UbiA; pfam01040 1245469017527 PUCC protein; Region: PUCC; pfam03209 1245469017528 geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023 1245469017529 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469017530 Cytochrome c; Region: Cytochrom_C; cl11414 1245469017531 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 1245469017532 PAS domain; Region: PAS; smart00091 1245469017533 putative active site [active] 1245469017534 heme pocket [chemical binding]; other site 1245469017535 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469017536 PAS fold; Region: PAS_2; pfam08446 1245469017537 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469017538 GAF domain; Region: GAF; pfam01590 1245469017539 Phytochrome region; Region: PHY; pfam00360 1245469017540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469017541 PAS domain; Region: PAS_9; pfam13426 1245469017542 putative active site [active] 1245469017543 heme pocket [chemical binding]; other site 1245469017544 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1245469017545 heme binding pocket [chemical binding]; other site 1245469017546 heme ligand [chemical binding]; other site 1245469017547 Subunit M of bacterial photosynthetic reaction center; Region: Photo-RC_M; cd09291 1245469017548 subunit H interface; other site 1245469017549 subunit L interface; other site 1245469017550 bacteriopheophytin binding site; other site 1245469017551 carotenoid binding site; other site 1245469017552 bacteriochlorophyll binding site; other site 1245469017553 cytochrome C interface; other site 1245469017554 quinone binding site; other site 1245469017555 Fe binding site [ion binding]; other site 1245469017556 Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290 1245469017557 subunit H interface; other site 1245469017558 subunit M interface; other site 1245469017559 quinone binding site; other site 1245469017560 bacteriopheophytin binding site; other site 1245469017561 bacteriochlorophyll binding site; other site 1245469017562 cytochrome C subunit interface; other site 1245469017563 Fe binding site [ion binding]; other site 1245469017564 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 1245469017565 Antenna complex alpha/beta subunit; Region: LHC; pfam00556 1245469017566 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1245469017567 chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014 1245469017568 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 1245469017569 Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY). Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980 1245469017570 chlorophyllide reductase subunit Y; Region: BchY; TIGR02015 1245469017571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469017572 chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016 1245469017573 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202 1245469017574 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1245469017575 putative NAD(P) binding site [chemical binding]; other site 1245469017576 O-methyltransferase; Region: Methyltransf_2; pfam00891 1245469017577 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1245469017578 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1245469017579 substrate binding pocket [chemical binding]; other site 1245469017580 chain length determination region; other site 1245469017581 substrate-Mg2+ binding site; other site 1245469017582 catalytic residues [active] 1245469017583 aspartate-rich region 1; other site 1245469017584 active site lid residues [active] 1245469017585 aspartate-rich region 2; other site 1245469017586 phytoene desaturase; Region: crtI_fam; TIGR02734 1245469017587 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1245469017588 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1245469017589 active site lid residues [active] 1245469017590 substrate binding pocket [chemical binding]; other site 1245469017591 catalytic residues [active] 1245469017592 substrate-Mg2+ binding site; other site 1245469017593 aspartate-rich region 1; other site 1245469017594 aspartate-rich region 2; other site 1245469017595 phytoene desaturase; Region: crtI_fam; TIGR02734 1245469017596 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469017597 putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056 1245469017598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469017599 magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406 1245469017600 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1245469017601 metal ion-dependent adhesion site (MIDAS); other site 1245469017602 magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407 1245469017603 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1245469017604 urocanate hydratase; Provisional; Region: PRK05414 1245469017605 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1245469017606 active sites [active] 1245469017607 tetramer interface [polypeptide binding]; other site 1245469017608 imidazolonepropionase; Validated; Region: PRK09356 1245469017609 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1245469017610 active site 1245469017611 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1245469017612 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1245469017613 active site 1245469017614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469017615 DNA-binding site [nucleotide binding]; DNA binding site 1245469017616 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 1245469017617 UTRA domain; Region: UTRA; pfam07702 1245469017618 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469017619 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1245469017620 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469017621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017622 dimer interface [polypeptide binding]; other site 1245469017623 conserved gate region; other site 1245469017624 putative PBP binding loops; other site 1245469017625 ABC-ATPase subunit interface; other site 1245469017626 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469017627 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469017628 Walker A/P-loop; other site 1245469017629 ATP binding site [chemical binding]; other site 1245469017630 Q-loop/lid; other site 1245469017631 ABC transporter signature motif; other site 1245469017632 Walker B; other site 1245469017633 D-loop; other site 1245469017634 H-loop/switch region; other site 1245469017635 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1245469017636 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1245469017637 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1245469017638 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1245469017639 Metal-binding active site; metal-binding site 1245469017640 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 1245469017641 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469017642 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469017643 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469017644 Walker A/P-loop; other site 1245469017645 ATP binding site [chemical binding]; other site 1245469017646 Q-loop/lid; other site 1245469017647 ABC transporter signature motif; other site 1245469017648 Walker B; other site 1245469017649 D-loop; other site 1245469017650 H-loop/switch region; other site 1245469017651 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469017652 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1245469017653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469017654 Walker A/P-loop; other site 1245469017655 ATP binding site [chemical binding]; other site 1245469017656 Q-loop/lid; other site 1245469017657 ABC transporter signature motif; other site 1245469017658 Walker B; other site 1245469017659 D-loop; other site 1245469017660 H-loop/switch region; other site 1245469017661 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1245469017662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469017663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017664 dimer interface [polypeptide binding]; other site 1245469017665 conserved gate region; other site 1245469017666 putative PBP binding loops; other site 1245469017667 ABC-ATPase subunit interface; other site 1245469017668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469017669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017670 dimer interface [polypeptide binding]; other site 1245469017671 conserved gate region; other site 1245469017672 ABC-ATPase subunit interface; other site 1245469017673 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1245469017674 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1245469017675 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469017676 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1245469017677 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1245469017678 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469017679 Walker A/P-loop; other site 1245469017680 ATP binding site [chemical binding]; other site 1245469017681 Q-loop/lid; other site 1245469017682 ABC transporter signature motif; other site 1245469017683 Walker B; other site 1245469017684 D-loop; other site 1245469017685 H-loop/switch region; other site 1245469017686 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469017687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469017688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469017689 Walker A/P-loop; other site 1245469017690 ATP binding site [chemical binding]; other site 1245469017691 Q-loop/lid; other site 1245469017692 ABC transporter signature motif; other site 1245469017693 Walker B; other site 1245469017694 D-loop; other site 1245469017695 H-loop/switch region; other site 1245469017696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469017697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1245469017698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017699 dimer interface [polypeptide binding]; other site 1245469017700 conserved gate region; other site 1245469017701 putative PBP binding loops; other site 1245469017702 ABC-ATPase subunit interface; other site 1245469017703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469017704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469017705 dimer interface [polypeptide binding]; other site 1245469017706 ABC-ATPase subunit interface; other site 1245469017707 putative PBP binding loops; other site 1245469017708 haloalkane dehalogenase; Provisional; Region: PRK03592 1245469017709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469017710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469017711 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1245469017712 beta-galactosidase; Region: BGL; TIGR03356 1245469017713 Glucokinase; Region: Glucokinase; pfam02685 1245469017714 glucokinase, proteobacterial type; Region: glk; TIGR00749 1245469017715 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1245469017716 putative substrate binding site [chemical binding]; other site 1245469017717 putative ATP binding site [chemical binding]; other site 1245469017718 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1245469017719 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1245469017720 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1245469017721 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1245469017722 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1245469017723 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1245469017724 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 1245469017725 active site 1245469017726 Zn binding site [ion binding]; other site 1245469017727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469017728 D-galactonate transporter; Region: 2A0114; TIGR00893 1245469017729 putative substrate translocation pore; other site 1245469017730 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1245469017731 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1245469017732 putative DNA binding site [nucleotide binding]; other site 1245469017733 putative homodimer interface [polypeptide binding]; other site 1245469017734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469017735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469017736 active site 1245469017737 phosphorylation site [posttranslational modification] 1245469017738 intermolecular recognition site; other site 1245469017739 dimerization interface [polypeptide binding]; other site 1245469017740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469017741 DNA binding site [nucleotide binding] 1245469017742 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1245469017743 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1245469017744 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1245469017745 Ligand Binding Site [chemical binding]; other site 1245469017746 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1245469017747 GAF domain; Region: GAF_3; pfam13492 1245469017748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469017749 dimer interface [polypeptide binding]; other site 1245469017750 phosphorylation site [posttranslational modification] 1245469017751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469017752 ATP binding site [chemical binding]; other site 1245469017753 Mg2+ binding site [ion binding]; other site 1245469017754 G-X-G motif; other site 1245469017755 potassium-transporting ATPase subunit C; Provisional; Region: PRK13999 1245469017756 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1245469017757 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1245469017758 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1245469017759 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1245469017760 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1245469017761 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1245469017762 dimer interface [polypeptide binding]; other site 1245469017763 active site 1245469017764 catalytic residue [active] 1245469017765 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469017766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469017767 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1245469017768 CPxP motif; other site 1245469017769 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1245469017770 Walker A motif; other site 1245469017771 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1245469017772 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1245469017773 GTP binding site; other site 1245469017774 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1245469017775 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469017776 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469017777 putative ligand binding site [chemical binding]; other site 1245469017778 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1245469017779 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469017780 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1245469017781 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1245469017782 active site 1245469017783 catalytic residues [active] 1245469017784 DNA binding site [nucleotide binding] 1245469017785 Int/Topo IB signature motif; other site 1245469017786 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1245469017787 AAA domain; Region: AAA_14; pfam13173 1245469017788 AAA domain; Region: AAA_21; pfam13304 1245469017789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469017790 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1245469017791 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1245469017792 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1245469017793 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1245469017794 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1245469017795 Walker A motif; other site 1245469017796 ATP binding site [chemical binding]; other site 1245469017797 Walker B motif; other site 1245469017798 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1245469017799 general secretion pathway protein J; Validated; Region: PRK08808 1245469017800 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1245469017801 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1245469017802 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1245469017803 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1245469017804 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1245469017805 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469017806 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469017807 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1245469017808 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469017809 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469017810 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469017811 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1245469017812 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017813 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017814 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017815 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017816 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017817 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1245469017818 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017819 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1245469017820 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1245469017821 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1245469017822 RHS Repeat; Region: RHS_repeat; pfam05593 1245469017823 RHS Repeat; Region: RHS_repeat; pfam05593 1245469017824 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1245469017825 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469017826 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469017827 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469017828 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1245469017829 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1245469017830 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469017831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469017832 Walker A/P-loop; other site 1245469017833 ATP binding site [chemical binding]; other site 1245469017834 Q-loop/lid; other site 1245469017835 ABC transporter signature motif; other site 1245469017836 Walker B; other site 1245469017837 D-loop; other site 1245469017838 H-loop/switch region; other site 1245469017839 TPR repeat; Region: TPR_11; pfam13414 1245469017840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469017841 binding surface 1245469017842 TPR motif; other site 1245469017843 TPR repeat; Region: TPR_11; pfam13414 1245469017844 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469017845 binding surface 1245469017846 TPR motif; other site 1245469017847 TPR repeat; Region: TPR_11; pfam13414 1245469017848 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469017849 VirB8 protein; Region: VirB8; cl01500 1245469017850 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1245469017851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1245469017852 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1245469017853 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1245469017854 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1245469017855 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1245469017856 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1245469017857 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1245469017858 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469017859 DNA binding residues [nucleotide binding] 1245469017860 dimerization interface [polypeptide binding]; other site 1245469017861 Integrase core domain; Region: rve; pfam00665 1245469017862 Integrase core domain; Region: rve_3; pfam13683 1245469017863 Transposase; Region: HTH_Tnp_1; pfam01527 1245469017864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469017865 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 1245469017866 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1245469017867 B12 binding site [chemical binding]; other site 1245469017868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1245469017869 FeS/SAM binding site; other site 1245469017870 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1245469017871 active site 1245469017872 nucleophile elbow; other site 1245469017873 transcriptional regulator TraR; Provisional; Region: PRK13870 1245469017874 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1245469017875 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469017876 DNA binding residues [nucleotide binding] 1245469017877 dimerization interface [polypeptide binding]; other site 1245469017878 Autoinducer synthetase; Region: Autoind_synth; cl17404 1245469017879 EamA-like transporter family; Region: EamA; pfam00892 1245469017880 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 1245469017881 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1245469017882 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1245469017883 active site 1245469017884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469017885 Coenzyme A binding pocket [chemical binding]; other site 1245469017886 B12 binding domain; Region: B12-binding; pfam02310 1245469017887 B12 binding site [chemical binding]; other site 1245469017888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469017889 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1245469017890 FeS/SAM binding site; other site 1245469017891 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1245469017892 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1245469017893 substrate-cofactor binding pocket; other site 1245469017894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469017895 catalytic residue [active] 1245469017896 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1245469017897 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469017898 EamA-like transporter family; Region: EamA; pfam00892 1245469017899 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469017900 Amidase; Region: Amidase; pfam01425 1245469017901 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1245469017902 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 1245469017903 metal binding site [ion binding]; metal-binding site 1245469017904 putative dimer interface [polypeptide binding]; other site 1245469017905 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1245469017906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469017907 Coenzyme A binding pocket [chemical binding]; other site 1245469017908 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1245469017909 active site 1245469017910 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1245469017911 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1245469017912 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1245469017913 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1245469017914 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 1245469017915 NAD(P) binding site [chemical binding]; other site 1245469017916 catalytic residues [active] 1245469017917 catalytic residues [active] 1245469017918 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1245469017919 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1245469017920 transmembrane helices; other site 1245469017921 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1245469017922 CoA binding domain; Region: CoA_binding_2; pfam13380 1245469017923 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1245469017924 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1245469017925 enoyl-CoA hydratase; Provisional; Region: PRK06688 1245469017926 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469017927 substrate binding site [chemical binding]; other site 1245469017928 oxyanion hole (OAH) forming residues; other site 1245469017929 trimer interface [polypeptide binding]; other site 1245469017930 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1245469017931 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469017932 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469017933 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1245469017934 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1245469017935 active site 1245469017936 DNA polymerase IV; Validated; Region: PRK02406 1245469017937 DNA binding site [nucleotide binding] 1245469017938 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469017939 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469017940 Walker A/P-loop; other site 1245469017941 ATP binding site [chemical binding]; other site 1245469017942 Q-loop/lid; other site 1245469017943 ABC transporter signature motif; other site 1245469017944 Walker B; other site 1245469017945 D-loop; other site 1245469017946 H-loop/switch region; other site 1245469017947 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469017948 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469017949 Walker A/P-loop; other site 1245469017950 ATP binding site [chemical binding]; other site 1245469017951 Q-loop/lid; other site 1245469017952 ABC transporter signature motif; other site 1245469017953 Walker B; other site 1245469017954 D-loop; other site 1245469017955 H-loop/switch region; other site 1245469017956 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469017957 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469017958 TM-ABC transporter signature motif; other site 1245469017959 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469017960 TM-ABC transporter signature motif; other site 1245469017961 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469017962 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 1245469017963 putative ligand binding site [chemical binding]; other site 1245469017964 Beta-lactamase; Region: Beta-lactamase; pfam00144 1245469017965 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1245469017966 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469017967 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469017968 putative ligand binding site [chemical binding]; other site 1245469017969 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469017970 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469017971 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1245469017972 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469017973 acyl-activating enzyme (AAE) consensus motif; other site 1245469017974 AMP binding site [chemical binding]; other site 1245469017975 active site 1245469017976 CoA binding site [chemical binding]; other site 1245469017977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469017978 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1245469017979 NAD(P) binding site [chemical binding]; other site 1245469017980 active site 1245469017981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469017982 S-adenosylmethionine binding site [chemical binding]; other site 1245469017983 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1245469017984 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1245469017985 Ligand Binding Site [chemical binding]; other site 1245469017986 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1245469017987 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1245469017988 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1245469017989 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 1245469017990 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1245469017991 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1245469017992 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1245469017993 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1245469017994 MgtE intracellular N domain; Region: MgtE_N; cl15244 1245469017995 FliG C-terminal domain; Region: FliG_C; pfam01706 1245469017996 flagellar assembly protein H; Validated; Region: fliH; PRK06032 1245469017997 Flagellar assembly protein FliH; Region: FliH; pfam02108 1245469017998 flagellar motor switch protein; Reviewed; Region: PRK08916 1245469017999 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469018000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469018001 Walker A motif; other site 1245469018002 ATP binding site [chemical binding]; other site 1245469018003 Walker B motif; other site 1245469018004 arginine finger; other site 1245469018005 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1245469018006 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1245469018007 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1245469018008 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469018009 Walker A/P-loop; other site 1245469018010 ATP binding site [chemical binding]; other site 1245469018011 Q-loop/lid; other site 1245469018012 ABC transporter signature motif; other site 1245469018013 Walker B; other site 1245469018014 D-loop; other site 1245469018015 H-loop/switch region; other site 1245469018016 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469018017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018018 dimer interface [polypeptide binding]; other site 1245469018019 conserved gate region; other site 1245469018020 putative PBP binding loops; other site 1245469018021 ABC-ATPase subunit interface; other site 1245469018022 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1245469018023 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1245469018024 active site 1245469018025 dimer interface [polypeptide binding]; other site 1245469018026 non-prolyl cis peptide bond; other site 1245469018027 insertion regions; other site 1245469018028 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469018029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469018030 substrate binding pocket [chemical binding]; other site 1245469018031 membrane-bound complex binding site; other site 1245469018032 hinge residues; other site 1245469018033 Periplasmic nitrate reductase protein NapE; Region: NapE; pfam06796 1245469018034 NapD protein; Region: NapD; pfam03927 1245469018035 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1245469018036 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1245469018037 [4Fe-4S] binding site [ion binding]; other site 1245469018038 molybdopterin cofactor binding site; other site 1245469018039 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1245469018040 molybdopterin cofactor binding site; other site 1245469018041 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 1245469018042 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 1245469018043 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1245469018044 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 1245469018045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469018046 Walker A motif; other site 1245469018047 ATP binding site [chemical binding]; other site 1245469018048 Walker B motif; other site 1245469018049 Family description; Region: UvrD_C_2; pfam13538 1245469018050 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1245469018051 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469018052 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469018053 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469018054 N-terminal domain interface [polypeptide binding]; other site 1245469018055 dimer interface [polypeptide binding]; other site 1245469018056 substrate binding pocket (H-site) [chemical binding]; other site 1245469018057 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1245469018058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469018059 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1245469018060 dimerization interface [polypeptide binding]; other site 1245469018061 substrate binding pocket [chemical binding]; other site 1245469018062 methionine sulfoxide reductase A; Provisional; Region: PRK13014 1245469018063 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1245469018064 SelR domain; Region: SelR; pfam01641 1245469018065 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1245469018066 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469018067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469018068 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1245469018069 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1245469018070 GDP-binding site [chemical binding]; other site 1245469018071 ACT binding site; other site 1245469018072 IMP binding site; other site 1245469018073 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469018074 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469018075 Walker A/P-loop; other site 1245469018076 ATP binding site [chemical binding]; other site 1245469018077 Q-loop/lid; other site 1245469018078 ABC transporter signature motif; other site 1245469018079 Walker B; other site 1245469018080 D-loop; other site 1245469018081 H-loop/switch region; other site 1245469018082 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1245469018083 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1245469018084 FtsX-like permease family; Region: FtsX; pfam02687 1245469018085 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469018086 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469018087 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469018088 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1245469018089 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1245469018090 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1245469018091 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1245469018092 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1245469018093 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1245469018094 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1245469018095 EamA-like transporter family; Region: EamA; pfam00892 1245469018096 EamA-like transporter family; Region: EamA; pfam00892 1245469018097 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469018098 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1245469018099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469018100 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1245469018101 EamA-like transporter family; Region: EamA; pfam00892 1245469018102 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1245469018103 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1245469018104 HAMP domain; Region: HAMP; pfam00672 1245469018105 dimerization interface [polypeptide binding]; other site 1245469018106 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469018107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469018108 dimer interface [polypeptide binding]; other site 1245469018109 putative CheW interface [polypeptide binding]; other site 1245469018110 FtsH Extracellular; Region: FtsH_ext; pfam06480 1245469018111 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1245469018112 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1245469018113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469018114 Walker A motif; other site 1245469018115 ATP binding site [chemical binding]; other site 1245469018116 Walker B motif; other site 1245469018117 arginine finger; other site 1245469018118 Peptidase family M41; Region: Peptidase_M41; pfam01434 1245469018119 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469018120 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469018121 putative ligand binding site [chemical binding]; other site 1245469018122 conserved hypothetical protein; Region: TIGR02231 1245469018123 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1245469018124 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1245469018125 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1245469018126 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1245469018127 ligand binding site [chemical binding]; other site 1245469018128 NAD binding site [chemical binding]; other site 1245469018129 dimerization interface [polypeptide binding]; other site 1245469018130 catalytic site [active] 1245469018131 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1245469018132 putative L-serine binding site [chemical binding]; other site 1245469018133 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 1245469018134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1245469018135 catalytic residue [active] 1245469018136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469018137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469018138 active site 1245469018139 catalytic tetrad [active] 1245469018140 Amidohydrolase; Region: Amidohydro_2; pfam04909 1245469018141 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1245469018142 active site 1245469018143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469018144 Coenzyme A binding pocket [chemical binding]; other site 1245469018145 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469018146 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 1245469018147 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1245469018148 active site 1245469018149 substrate binding site [chemical binding]; other site 1245469018150 metal binding site [ion binding]; metal-binding site 1245469018151 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1245469018152 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1245469018153 phosphate binding site [ion binding]; other site 1245469018154 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1245469018155 generic binding surface II; other site 1245469018156 generic binding surface I; other site 1245469018157 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1245469018158 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1245469018159 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1245469018160 shikimate binding site; other site 1245469018161 NAD(P) binding site [chemical binding]; other site 1245469018162 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1245469018163 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1245469018164 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1245469018165 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1245469018166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469018167 non-specific DNA binding site [nucleotide binding]; other site 1245469018168 salt bridge; other site 1245469018169 sequence-specific DNA binding site [nucleotide binding]; other site 1245469018170 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1245469018171 elongation factor G; Reviewed; Region: PRK12740 1245469018172 G1 box; other site 1245469018173 putative GEF interaction site [polypeptide binding]; other site 1245469018174 GTP/Mg2+ binding site [chemical binding]; other site 1245469018175 Switch I region; other site 1245469018176 G2 box; other site 1245469018177 G3 box; other site 1245469018178 Switch II region; other site 1245469018179 G4 box; other site 1245469018180 G5 box; other site 1245469018181 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1245469018182 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1245469018183 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1245469018184 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1245469018185 Protein of unknown function (DUF992); Region: DUF992; pfam06186 1245469018186 aspartate aminotransferase; Provisional; Region: PRK05764 1245469018187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469018188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469018189 homodimer interface [polypeptide binding]; other site 1245469018190 catalytic residue [active] 1245469018191 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1245469018192 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469018193 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1245469018194 putative C-terminal domain interface [polypeptide binding]; other site 1245469018195 putative GSH binding site (G-site) [chemical binding]; other site 1245469018196 putative dimer interface [polypeptide binding]; other site 1245469018197 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469018198 N-terminal domain interface [polypeptide binding]; other site 1245469018199 dimer interface [polypeptide binding]; other site 1245469018200 substrate binding pocket (H-site) [chemical binding]; other site 1245469018201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1245469018202 Coenzyme A binding pocket [chemical binding]; other site 1245469018203 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1245469018204 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1245469018205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 1245469018206 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 1245469018207 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1245469018208 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469018209 motif II; other site 1245469018210 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1245469018211 putative FMN binding site [chemical binding]; other site 1245469018212 NADPH bind site [chemical binding]; other site 1245469018213 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469018214 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469018215 enoyl-CoA hydratase; Provisional; Region: PRK05980 1245469018216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469018217 substrate binding site [chemical binding]; other site 1245469018218 oxyanion hole (OAH) forming residues; other site 1245469018219 trimer interface [polypeptide binding]; other site 1245469018220 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 1245469018221 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469018222 putative C-terminal domain interface [polypeptide binding]; other site 1245469018223 putative GSH binding site (G-site) [chemical binding]; other site 1245469018224 putative dimer interface [polypeptide binding]; other site 1245469018225 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 1245469018226 putative dimer interface [polypeptide binding]; other site 1245469018227 putative N-terminal domain interface [polypeptide binding]; other site 1245469018228 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469018229 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1245469018230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469018231 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1245469018232 dimerization interface [polypeptide binding]; other site 1245469018233 substrate binding pocket [chemical binding]; other site 1245469018234 excinuclease ABC subunit B; Provisional; Region: PRK05298 1245469018235 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469018236 ATP binding site [chemical binding]; other site 1245469018237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469018238 nucleotide binding region [chemical binding]; other site 1245469018239 ATP-binding site [chemical binding]; other site 1245469018240 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1245469018241 UvrB/uvrC motif; Region: UVR; pfam02151 1245469018242 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1245469018243 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469018244 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469018245 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469018246 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1245469018247 putative active site [active] 1245469018248 putative catalytic site [active] 1245469018249 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1245469018250 putative active site [active] 1245469018251 putative catalytic site [active] 1245469018252 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 1245469018253 GTP-binding protein YchF; Reviewed; Region: PRK09601 1245469018254 YchF GTPase; Region: YchF; cd01900 1245469018255 G1 box; other site 1245469018256 GTP/Mg2+ binding site [chemical binding]; other site 1245469018257 Switch I region; other site 1245469018258 G2 box; other site 1245469018259 Switch II region; other site 1245469018260 G3 box; other site 1245469018261 G4 box; other site 1245469018262 G5 box; other site 1245469018263 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1245469018264 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1245469018265 putative active site [active] 1245469018266 catalytic residue [active] 1245469018267 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1245469018268 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1245469018269 5S rRNA interface [nucleotide binding]; other site 1245469018270 CTC domain interface [polypeptide binding]; other site 1245469018271 L16 interface [polypeptide binding]; other site 1245469018272 Membrane fusogenic activity; Region: BMFP; pfam04380 1245469018273 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1245469018274 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1245469018275 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 1245469018276 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1245469018277 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1245469018278 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1245469018279 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1245469018280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469018281 active site 1245469018282 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1245469018283 benzoate transporter; Region: benE; TIGR00843 1245469018284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1245469018285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1245469018286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018287 dimer interface [polypeptide binding]; other site 1245469018288 conserved gate region; other site 1245469018289 putative PBP binding loops; other site 1245469018290 ABC-ATPase subunit interface; other site 1245469018291 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1245469018292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018293 dimer interface [polypeptide binding]; other site 1245469018294 conserved gate region; other site 1245469018295 putative PBP binding loops; other site 1245469018296 ABC-ATPase subunit interface; other site 1245469018297 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469018298 GAF domain; Region: GAF; pfam01590 1245469018299 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469018300 HWE histidine kinase; Region: HWE_HK; smart00911 1245469018301 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1245469018302 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1245469018303 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1245469018304 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1245469018305 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1245469018306 metal ion-dependent adhesion site (MIDAS); other site 1245469018307 MoxR-like ATPases [General function prediction only]; Region: COG0714 1245469018308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469018309 Walker A motif; other site 1245469018310 ATP binding site [chemical binding]; other site 1245469018311 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1245469018312 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1245469018313 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469018314 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469018315 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469018316 catalytic loop [active] 1245469018317 iron binding site [ion binding]; other site 1245469018318 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469018319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1245469018320 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1245469018321 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1245469018322 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1245469018323 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1245469018324 LytTr DNA-binding domain; Region: LytTR; smart00850 1245469018325 riboflavin synthase subunit beta; Provisional; Region: PRK12419 1245469018326 active site 1245469018327 homopentamer interface [polypeptide binding]; other site 1245469018328 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1245469018329 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1245469018330 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1245469018331 Predicted thioesterase [General function prediction only]; Region: COG5496 1245469018332 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1245469018333 active site 1 [active] 1245469018334 dimer interface [polypeptide binding]; other site 1245469018335 hexamer interface [polypeptide binding]; other site 1245469018336 active site 2 [active] 1245469018337 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1245469018338 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1245469018339 dimer interface [polypeptide binding]; other site 1245469018340 motif 1; other site 1245469018341 motif 2; other site 1245469018342 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1245469018343 active site 1245469018344 motif 3; other site 1245469018345 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1245469018346 anticodon binding site; other site 1245469018347 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1245469018348 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1245469018349 homodimer interface [polypeptide binding]; other site 1245469018350 substrate-cofactor binding pocket; other site 1245469018351 catalytic residue [active] 1245469018352 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469018353 MarR family; Region: MarR_2; pfam12802 1245469018354 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1245469018355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469018356 active site 1245469018357 phosphorylation site [posttranslational modification] 1245469018358 intermolecular recognition site; other site 1245469018359 dimerization interface [polypeptide binding]; other site 1245469018360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469018361 DNA binding site [nucleotide binding] 1245469018362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1245469018363 dimerization interface [polypeptide binding]; other site 1245469018364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469018365 dimer interface [polypeptide binding]; other site 1245469018366 phosphorylation site [posttranslational modification] 1245469018367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469018368 ATP binding site [chemical binding]; other site 1245469018369 Mg2+ binding site [ion binding]; other site 1245469018370 G-X-G motif; other site 1245469018371 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1245469018372 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1245469018373 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1245469018374 active site 1245469018375 Fe binding site [ion binding]; other site 1245469018376 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1245469018377 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469018378 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469018379 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1245469018380 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469018381 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469018382 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469018383 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469018384 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469018385 putative ligand binding site [chemical binding]; other site 1245469018386 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1245469018387 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1245469018388 NAD(P) binding site [chemical binding]; other site 1245469018389 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 1245469018390 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1245469018391 B1 nucleotide binding pocket [chemical binding]; other site 1245469018392 B2 nucleotide binding pocket [chemical binding]; other site 1245469018393 CAS motifs; other site 1245469018394 active site 1245469018395 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1245469018396 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469018397 DNA-binding site [nucleotide binding]; DNA binding site 1245469018398 RNA-binding motif; other site 1245469018399 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469018400 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1245469018401 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1245469018402 GIY-YIG motif/motif A; other site 1245469018403 active site 1245469018404 catalytic site [active] 1245469018405 putative DNA binding site [nucleotide binding]; other site 1245469018406 metal binding site [ion binding]; metal-binding site 1245469018407 UvrB/uvrC motif; Region: UVR; pfam02151 1245469018408 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1245469018409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1245469018410 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 1245469018411 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1245469018412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469018413 dimerization interface [polypeptide binding]; other site 1245469018414 putative DNA binding site [nucleotide binding]; other site 1245469018415 putative Zn2+ binding site [ion binding]; other site 1245469018416 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469018417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469018418 putative DNA binding site [nucleotide binding]; other site 1245469018419 putative Zn2+ binding site [ion binding]; other site 1245469018420 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469018421 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1245469018422 NAD(P) binding site [chemical binding]; other site 1245469018423 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1245469018424 GIY-YIG motif/motif A; other site 1245469018425 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1245469018426 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1245469018427 MoaE interaction surface [polypeptide binding]; other site 1245469018428 MoeB interaction surface [polypeptide binding]; other site 1245469018429 thiocarboxylated glycine; other site 1245469018430 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1245469018431 MoaE homodimer interface [polypeptide binding]; other site 1245469018432 MoaD interaction [polypeptide binding]; other site 1245469018433 active site residues [active] 1245469018434 HemK family putative methylases; Region: hemK_fam; TIGR00536 1245469018435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469018436 S-adenosylmethionine binding site [chemical binding]; other site 1245469018437 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 1245469018438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1245469018439 inhibitor-cofactor binding pocket; inhibition site 1245469018440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469018441 catalytic residue [active] 1245469018442 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1245469018443 Fic/DOC family; Region: Fic; pfam02661 1245469018444 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 1245469018445 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469018446 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 1245469018447 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469018448 active site 1245469018449 motif I; other site 1245469018450 motif II; other site 1245469018451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469018452 short chain dehydrogenase; Provisional; Region: PRK06180 1245469018453 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1245469018454 NADP binding site [chemical binding]; other site 1245469018455 active site 1245469018456 steroid binding site; other site 1245469018457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469018458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469018459 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1245469018460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469018461 active site 1245469018462 phosphorylation site [posttranslational modification] 1245469018463 intermolecular recognition site; other site 1245469018464 dimerization interface [polypeptide binding]; other site 1245469018465 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1245469018466 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1245469018467 active site 1245469018468 Riboflavin kinase; Region: Flavokinase; pfam01687 1245469018469 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 1245469018470 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1245469018471 active site 1245469018472 HIGH motif; other site 1245469018473 nucleotide binding site [chemical binding]; other site 1245469018474 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1245469018475 active site 1245469018476 KMSKS motif; other site 1245469018477 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1245469018478 tRNA binding surface [nucleotide binding]; other site 1245469018479 anticodon binding site; other site 1245469018480 lipoprotein signal peptidase; Provisional; Region: PRK14796 1245469018481 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1245469018482 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1245469018483 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1245469018484 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1245469018485 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1245469018486 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1245469018487 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1245469018488 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469018489 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469018490 DNA binding residues [nucleotide binding] 1245469018491 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1245469018492 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469018493 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1245469018494 Domain of unknown function (DUF305); Region: DUF305; cl17794 1245469018495 hypothetical protein; Provisional; Region: PRK09256 1245469018496 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1245469018497 Cytochrome c; Region: Cytochrom_C; cl11414 1245469018498 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469018499 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1245469018500 active site 1245469018501 dimer interface [polypeptide binding]; other site 1245469018502 metal binding site [ion binding]; metal-binding site 1245469018503 glutathione binding site [chemical binding]; other site 1245469018504 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1245469018505 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1245469018506 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469018507 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 1245469018508 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1245469018509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469018510 ATP binding site [chemical binding]; other site 1245469018511 Mg2+ binding site [ion binding]; other site 1245469018512 G-X-G motif; other site 1245469018513 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1245469018514 ATP binding site [chemical binding]; other site 1245469018515 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1245469018516 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1245469018517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469018518 S-adenosylmethionine binding site [chemical binding]; other site 1245469018519 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1245469018520 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469018521 RNA binding surface [nucleotide binding]; other site 1245469018522 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1245469018523 active site 1245469018524 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1245469018525 nucleoside/Zn binding site; other site 1245469018526 dimer interface [polypeptide binding]; other site 1245469018527 catalytic motif [active] 1245469018528 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469018529 Cytochrome P450; Region: p450; cl12078 1245469018530 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1245469018531 S-adenosylmethionine binding site [chemical binding]; other site 1245469018532 Double zinc ribbon; Region: DZR; pfam12773 1245469018533 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 1245469018534 cyclase homology domain; Region: CHD; cd07302 1245469018535 nucleotidyl binding site; other site 1245469018536 metal binding site [ion binding]; metal-binding site 1245469018537 dimer interface [polypeptide binding]; other site 1245469018538 AAA ATPase domain; Region: AAA_16; pfam13191 1245469018539 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1245469018540 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1245469018541 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1245469018542 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1245469018543 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1245469018544 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469018545 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469018546 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1245469018547 catalytic site [active] 1245469018548 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1245469018549 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1245469018550 generic binding surface II; other site 1245469018551 generic binding surface I; other site 1245469018552 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469018553 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469018554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908 1245469018555 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1245469018556 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 1245469018557 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1245469018558 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1245469018559 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469018560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1245469018561 putative acyl-acceptor binding pocket; other site 1245469018562 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 1245469018563 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1245469018564 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1245469018565 active site 1245469018566 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1245469018567 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 1245469018568 UbiA prenyltransferase family; Region: UbiA; pfam01040 1245469018569 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1245469018570 RNA methyltransferase, RsmE family; Region: TIGR00046 1245469018571 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 1245469018572 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1245469018573 motif 1; other site 1245469018574 dimer interface [polypeptide binding]; other site 1245469018575 active site 1245469018576 motif 2; other site 1245469018577 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1245469018578 active site 1245469018579 motif 3; other site 1245469018580 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1245469018581 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 1245469018582 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1245469018583 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1245469018584 Ligand binding site; other site 1245469018585 Putative Catalytic site; other site 1245469018586 DXD motif; other site 1245469018587 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_3; cd10807 1245469018588 putative active site [active] 1245469018589 YdjC motif; other site 1245469018590 Mg binding site [ion binding]; other site 1245469018591 putative homodimer interface [polypeptide binding]; other site 1245469018592 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 1245469018593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469018594 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469018595 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1245469018596 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1245469018597 oligomerisation interface [polypeptide binding]; other site 1245469018598 mobile loop; other site 1245469018599 roof hairpin; other site 1245469018600 chaperonin GroEL; Reviewed; Region: groEL; PRK12852 1245469018601 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1245469018602 ring oligomerisation interface [polypeptide binding]; other site 1245469018603 ATP/Mg binding site [chemical binding]; other site 1245469018604 stacking interactions; other site 1245469018605 hinge regions; other site 1245469018606 L-lactate permease; Region: Lactate_perm; cl00701 1245469018607 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1245469018608 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1245469018609 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1245469018610 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1245469018611 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1245469018612 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1245469018613 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1245469018614 Cysteine-rich domain; Region: CCG; pfam02754 1245469018615 Cysteine-rich domain; Region: CCG; pfam02754 1245469018616 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469018617 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1245469018618 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1245469018619 methionine gamma-lyase; Validated; Region: PRK07049 1245469018620 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1245469018621 homodimer interface [polypeptide binding]; other site 1245469018622 substrate-cofactor binding pocket; other site 1245469018623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469018624 catalytic residue [active] 1245469018625 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1245469018626 Fic/DOC family; Region: Fic; cl00960 1245469018627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1245469018628 ATP binding site [chemical binding]; other site 1245469018629 Mg2+ binding site [ion binding]; other site 1245469018630 G-X-G motif; other site 1245469018631 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1245469018632 FAD binding domain; Region: FAD_binding_4; pfam01565 1245469018633 Cytochrome c2 [Energy production and conversion]; Region: COG3474 1245469018634 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1245469018635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469018636 catalytic site [active] 1245469018637 TPR repeat; Region: TPR_11; pfam13414 1245469018638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469018639 binding surface 1245469018640 TPR motif; other site 1245469018641 TPR repeat; Region: TPR_11; pfam13414 1245469018642 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1245469018643 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1245469018644 active site 1245469018645 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1245469018646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469018647 motif II; other site 1245469018648 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1245469018649 putative deacylase active site [active] 1245469018650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1245469018651 LysR family transcriptional regulator; Provisional; Region: PRK14997 1245469018652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469018653 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469018654 putative effector binding pocket; other site 1245469018655 dimerization interface [polypeptide binding]; other site 1245469018656 Pirin-related protein [General function prediction only]; Region: COG1741 1245469018657 Pirin; Region: Pirin; pfam02678 1245469018658 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1245469018659 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1245469018660 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1245469018661 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1245469018662 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1245469018663 homodimer interface [polypeptide binding]; other site 1245469018664 substrate-cofactor binding pocket; other site 1245469018665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469018666 catalytic residue [active] 1245469018667 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1245469018668 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1245469018669 Walker A/P-loop; other site 1245469018670 ATP binding site [chemical binding]; other site 1245469018671 Q-loop/lid; other site 1245469018672 ABC transporter signature motif; other site 1245469018673 Walker B; other site 1245469018674 D-loop; other site 1245469018675 H-loop/switch region; other site 1245469018676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018677 dimer interface [polypeptide binding]; other site 1245469018678 conserved gate region; other site 1245469018679 putative PBP binding loops; other site 1245469018680 ABC-ATPase subunit interface; other site 1245469018681 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1245469018682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018683 dimer interface [polypeptide binding]; other site 1245469018684 conserved gate region; other site 1245469018685 putative PBP binding loops; other site 1245469018686 ABC-ATPase subunit interface; other site 1245469018687 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1245469018688 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469018689 substrate binding pocket [chemical binding]; other site 1245469018690 membrane-bound complex binding site; other site 1245469018691 hinge residues; other site 1245469018692 hypothetical protein; Provisional; Region: PRK07079 1245469018693 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 1245469018694 metal binding site [ion binding]; metal-binding site 1245469018695 putative dimer interface [polypeptide binding]; other site 1245469018696 benzoylformate decarboxylase; Reviewed; Region: PRK07092 1245469018697 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1245469018698 PYR/PP interface [polypeptide binding]; other site 1245469018699 dimer interface [polypeptide binding]; other site 1245469018700 TPP binding site [chemical binding]; other site 1245469018701 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1245469018702 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1245469018703 TPP-binding site [chemical binding]; other site 1245469018704 dimer interface [polypeptide binding]; other site 1245469018705 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469018706 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1245469018707 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1245469018708 FMN binding site [chemical binding]; other site 1245469018709 active site 1245469018710 substrate binding site [chemical binding]; other site 1245469018711 catalytic residue [active] 1245469018712 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1245469018713 hypothetical protein; Provisional; Region: PRK06194 1245469018714 classical (c) SDRs; Region: SDR_c; cd05233 1245469018715 NAD(P) binding site [chemical binding]; other site 1245469018716 active site 1245469018717 yiaA/B two helix domain; Region: YiaAB; cl01759 1245469018718 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1245469018719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469018720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469018721 WHG domain; Region: WHG; pfam13305 1245469018722 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469018723 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1245469018724 putative ligand binding site [chemical binding]; other site 1245469018725 Helix-turn-helix domain; Region: HTH_18; pfam12833 1245469018726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469018727 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1245469018728 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1245469018729 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469018730 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469018731 ligand binding site [chemical binding]; other site 1245469018732 flexible hinge region; other site 1245469018733 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469018734 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469018735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 1245469018736 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1245469018737 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469018738 GAF domain; Region: GAF; pfam01590 1245469018739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469018740 Histidine kinase; Region: HisKA_2; pfam07568 1245469018741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469018742 ATP binding site [chemical binding]; other site 1245469018743 Mg2+ binding site [ion binding]; other site 1245469018744 G-X-G motif; other site 1245469018745 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1245469018746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469018747 NAD(P) binding site [chemical binding]; other site 1245469018748 active site 1245469018749 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1245469018750 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469018751 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469018752 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1245469018753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469018754 putative substrate translocation pore; other site 1245469018755 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1245469018756 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1245469018757 MlrC C-terminus; Region: MlrC_C; pfam07171 1245469018758 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469018759 cyclase homology domain; Region: CHD; cd07302 1245469018760 nucleotidyl binding site; other site 1245469018761 metal binding site [ion binding]; metal-binding site 1245469018762 dimer interface [polypeptide binding]; other site 1245469018763 2TM domain; Region: 2TM; pfam13239 1245469018764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469018765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469018766 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469018767 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469018768 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 1245469018769 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1245469018770 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1245469018771 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469018772 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1245469018773 Walker A/P-loop; other site 1245469018774 ATP binding site [chemical binding]; other site 1245469018775 Q-loop/lid; other site 1245469018776 ABC transporter signature motif; other site 1245469018777 Walker B; other site 1245469018778 D-loop; other site 1245469018779 H-loop/switch region; other site 1245469018780 TOBE domain; Region: TOBE_2; pfam08402 1245469018781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018782 dimer interface [polypeptide binding]; other site 1245469018783 conserved gate region; other site 1245469018784 putative PBP binding loops; other site 1245469018785 ABC-ATPase subunit interface; other site 1245469018786 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469018787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469018788 dimer interface [polypeptide binding]; other site 1245469018789 conserved gate region; other site 1245469018790 putative PBP binding loops; other site 1245469018791 ABC-ATPase subunit interface; other site 1245469018792 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1245469018793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469018794 NAD(P) binding site [chemical binding]; other site 1245469018795 active site 1245469018796 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469018797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469018798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469018799 WHG domain; Region: WHG; pfam13305 1245469018800 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1245469018801 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 1245469018802 putative hydrophobic ligand binding site [chemical binding]; other site 1245469018803 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1245469018804 active site 1245469018805 zinc binding site [ion binding]; other site 1245469018806 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469018807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469018808 active site 1245469018809 phosphorylation site [posttranslational modification] 1245469018810 intermolecular recognition site; other site 1245469018811 dimerization interface [polypeptide binding]; other site 1245469018812 N-formylglutamate amidohydrolase [Amino acid transport and metabolism]; Region: HutG; COG3741 1245469018813 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1245469018814 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1245469018815 active site 1245469018816 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1245469018817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469018818 dimerization interface [polypeptide binding]; other site 1245469018819 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469018820 dimer interface [polypeptide binding]; other site 1245469018821 putative CheW interface [polypeptide binding]; other site 1245469018822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469018823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469018824 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 1245469018825 putative dimerization interface [polypeptide binding]; other site 1245469018826 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1245469018827 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1245469018828 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469018829 cyclase homology domain; Region: CHD; cd07302 1245469018830 nucleotidyl binding site; other site 1245469018831 metal binding site [ion binding]; metal-binding site 1245469018832 dimer interface [polypeptide binding]; other site 1245469018833 Predicted integral membrane protein [Function unknown]; Region: COG5616 1245469018834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469018835 TPR motif; other site 1245469018836 binding surface 1245469018837 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1245469018838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469018839 TPR motif; other site 1245469018840 binding surface 1245469018841 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469018842 cyclase homology domain; Region: CHD; cd07302 1245469018843 nucleotidyl binding site; other site 1245469018844 metal binding site [ion binding]; metal-binding site 1245469018845 dimer interface [polypeptide binding]; other site 1245469018846 Predicted integral membrane protein [Function unknown]; Region: COG5616 1245469018847 TPR repeat; Region: TPR_11; pfam13414 1245469018848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469018849 TPR motif; other site 1245469018850 binding surface 1245469018851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469018852 TPR motif; other site 1245469018853 binding surface 1245469018854 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1245469018855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1245469018856 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 1245469018857 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1245469018858 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1245469018859 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469018860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1245469018861 dimerization interface [polypeptide binding]; other site 1245469018862 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469018863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469018864 DNA-binding site [nucleotide binding]; DNA binding site 1245469018865 FCD domain; Region: FCD; pfam07729 1245469018866 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469018867 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469018868 putative ligand binding site [chemical binding]; other site 1245469018869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469018870 HWE histidine kinase; Region: HWE_HK; smart00911 1245469018871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469018872 binding surface 1245469018873 TPR motif; other site 1245469018874 TPR repeat; Region: TPR_11; pfam13414 1245469018875 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1245469018876 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469018877 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1245469018878 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1245469018879 putative dimer interface [polypeptide binding]; other site 1245469018880 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469018881 Lentivirus surface glycoprotein; Region: Env-gp36; pfam09590 1245469018882 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1245469018883 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1245469018884 active site 1245469018885 dimer interface [polypeptide binding]; other site 1245469018886 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1245469018887 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1245469018888 active site 1245469018889 FMN binding site [chemical binding]; other site 1245469018890 substrate binding site [chemical binding]; other site 1245469018891 3Fe-4S cluster binding site [ion binding]; other site 1245469018892 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1245469018893 domain interface; other site 1245469018894 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1245469018895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1245469018896 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1245469018897 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1245469018898 Predicted transcriptional regulators [Transcription]; Region: COG1733 1245469018899 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1245469018900 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1245469018901 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1245469018902 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1245469018903 putative active site [active] 1245469018904 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1245469018905 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1245469018906 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1245469018907 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1245469018908 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1245469018909 ferrochelatase; Reviewed; Region: hemH; PRK00035 1245469018910 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1245469018911 C-terminal domain interface [polypeptide binding]; other site 1245469018912 active site 1245469018913 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1245469018914 active site 1245469018915 N-terminal domain interface [polypeptide binding]; other site 1245469018916 MAPEG family; Region: MAPEG; cl09190 1245469018917 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1245469018918 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 1245469018919 Active site cavity [active] 1245469018920 catalytic acid [active] 1245469018921 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1245469018922 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1245469018923 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1245469018924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469018925 putative substrate translocation pore; other site 1245469018926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469018927 High-affinity nickel-transport protein; Region: NicO; cl00964 1245469018928 High-affinity nickel-transport protein; Region: NicO; cl00964 1245469018929 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 1245469018930 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1245469018931 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1245469018932 active site 1245469018933 Zn binding site [ion binding]; other site 1245469018934 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1245469018935 dimer interface [polypeptide binding]; other site 1245469018936 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1245469018937 active site 1245469018938 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469018939 catalytic residues [active] 1245469018940 substrate binding site [chemical binding]; other site 1245469018941 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1245469018942 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1245469018943 homotrimer interaction site [polypeptide binding]; other site 1245469018944 putative active site [active] 1245469018945 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 1245469018946 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1245469018947 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1245469018948 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1245469018949 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1245469018950 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1245469018951 P-loop, Walker A motif; other site 1245469018952 Base recognition motif; other site 1245469018953 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1245469018954 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1245469018955 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1245469018956 metal binding site [ion binding]; metal-binding site 1245469018957 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1245469018958 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1245469018959 ABC-ATPase subunit interface; other site 1245469018960 dimer interface [polypeptide binding]; other site 1245469018961 putative PBP binding regions; other site 1245469018962 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1245469018963 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1245469018964 camphor resistance protein CrcB; Provisional; Region: PRK14198 1245469018965 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1245469018966 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1245469018967 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1245469018968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1245469018969 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 1245469018970 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 1245469018971 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 1245469018972 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1245469018973 MgtC family; Region: MgtC; pfam02308 1245469018974 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1245469018975 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1245469018976 Hemerythrin-like domain; Region: Hr-like; cd12108 1245469018977 Fe binding site [ion binding]; other site 1245469018978 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1245469018979 classical (c) SDRs; Region: SDR_c; cd05233 1245469018980 NAD(P) binding site [chemical binding]; other site 1245469018981 active site 1245469018982 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1245469018983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469018984 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469018985 acyl-activating enzyme (AAE) consensus motif; other site 1245469018986 acyl-activating enzyme (AAE) consensus motif; other site 1245469018987 AMP binding site [chemical binding]; other site 1245469018988 active site 1245469018989 CoA binding site [chemical binding]; other site 1245469018990 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1245469018991 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1245469018992 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1245469018993 acyl-activating enzyme (AAE) consensus motif; other site 1245469018994 putative AMP binding site [chemical binding]; other site 1245469018995 putative active site [active] 1245469018996 putative CoA binding site [chemical binding]; other site 1245469018997 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1245469018998 heat shock protein 90; Provisional; Region: PRK05218 1245469018999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469019000 ATP binding site [chemical binding]; other site 1245469019001 Mg2+ binding site [ion binding]; other site 1245469019002 G-X-G motif; other site 1245469019003 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469019004 MarR family; Region: MarR; pfam01047 1245469019005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469019006 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1245469019007 Zn binding site [ion binding]; other site 1245469019008 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 1245469019009 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469019010 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 1245469019011 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469019012 Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663 1245469019013 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1245469019014 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469019015 N-terminal plug; other site 1245469019016 ligand-binding site [chemical binding]; other site 1245469019017 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1245469019018 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1245469019019 N-terminal plug; other site 1245469019020 ligand-binding site [chemical binding]; other site 1245469019021 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1245469019022 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1245469019023 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1245469019024 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1245469019025 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1245469019026 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1245469019027 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1245469019028 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1245469019029 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 1245469019030 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1245469019031 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1245469019032 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1245469019033 Part of AAA domain; Region: AAA_19; pfam13245 1245469019034 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469019035 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1245469019036 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1245469019037 diiron binding motif [ion binding]; other site 1245469019038 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1245469019039 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 1245469019040 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1245469019041 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1245469019042 nitrous-oxide reductase; Validated; Region: PRK02888 1245469019043 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208 1245469019044 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1245469019045 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1245469019046 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 1245469019047 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1245469019048 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1245469019049 Walker A/P-loop; other site 1245469019050 ATP binding site [chemical binding]; other site 1245469019051 Q-loop/lid; other site 1245469019052 ABC transporter signature motif; other site 1245469019053 Walker B; other site 1245469019054 D-loop; other site 1245469019055 H-loop/switch region; other site 1245469019056 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1245469019057 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1245469019058 NosL; Region: NosL; cl01769 1245469019059 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1245469019060 ApbE family; Region: ApbE; pfam02424 1245469019061 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 1245469019062 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1245469019063 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 1245469019064 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1245469019065 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 1245469019066 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1245469019067 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1245469019068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469019069 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 1245469019070 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1245469019071 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1245469019072 HupE / UreJ protein; Region: HupE_UreJ; pfam04955 1245469019073 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 1245469019074 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1245469019075 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1245469019076 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 1245469019077 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1245469019078 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1245469019079 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1245469019080 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1245469019081 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469019082 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1245469019083 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1245469019084 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469019085 Walker A motif; other site 1245469019086 ATP binding site [chemical binding]; other site 1245469019087 Walker B motif; other site 1245469019088 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1245469019089 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469019090 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1245469019091 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469019092 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1245469019093 Sel1-like repeats; Region: SEL1; smart00671 1245469019094 Sel1-like repeats; Region: SEL1; smart00671 1245469019095 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 1245469019096 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1245469019097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1245469019098 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1245469019099 catalytic residue [active] 1245469019100 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1245469019101 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1245469019102 TonB C terminal; Region: TonB_2; pfam13103 1245469019103 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1245469019104 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1245469019105 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 1245469019106 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1245469019107 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1245469019108 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1245469019109 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1245469019110 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1245469019111 FecR protein; Region: FecR; pfam04773 1245469019112 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1245469019113 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1245469019114 DNA binding residues [nucleotide binding] 1245469019115 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1245469019116 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1245469019117 PBP superfamily domain; Region: PBP_like_2; cl17296 1245469019118 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1245469019119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469019120 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1245469019121 DNA binding residues [nucleotide binding] 1245469019122 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1245469019123 Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545 1245469019124 Secretin and TonB N terminus short domain; Region: STN; smart00965 1245469019125 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1245469019126 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 1245469019127 NAD(P) binding site [chemical binding]; other site 1245469019128 catalytic residues [active] 1245469019129 choline dehydrogenase; Validated; Region: PRK02106 1245469019130 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1245469019131 short chain dehydrogenase; Provisional; Region: PRK06949 1245469019132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469019133 NAD(P) binding site [chemical binding]; other site 1245469019134 active site 1245469019135 Colicin V production protein; Region: Colicin_V; pfam02674 1245469019136 short chain dehydrogenase; Provisional; Region: PRK08339 1245469019137 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1245469019138 putative NAD(P) binding site [chemical binding]; other site 1245469019139 putative active site [active] 1245469019140 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 1245469019141 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469019142 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1245469019143 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1245469019144 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469019145 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469019146 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1245469019147 dimer interface [polypeptide binding]; other site 1245469019148 N-terminal domain interface [polypeptide binding]; other site 1245469019149 putative substrate binding pocket (H-site) [chemical binding]; other site 1245469019150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469019151 Cupin domain; Region: Cupin_2; cl17218 1245469019152 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1245469019153 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1245469019154 DNA binding site [nucleotide binding] 1245469019155 active site 1245469019156 glutamate carboxypeptidase; Reviewed; Region: PRK06133 1245469019157 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1245469019158 metal binding site [ion binding]; metal-binding site 1245469019159 dimer interface [polypeptide binding]; other site 1245469019160 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1245469019161 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1245469019162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1245469019163 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1245469019164 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1245469019165 Peptidase family M23; Region: Peptidase_M23; pfam01551 1245469019166 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1245469019167 Clp amino terminal domain; Region: Clp_N; pfam02861 1245469019168 Clp amino terminal domain; Region: Clp_N; pfam02861 1245469019169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469019170 Walker A motif; other site 1245469019171 ATP binding site [chemical binding]; other site 1245469019172 Walker B motif; other site 1245469019173 arginine finger; other site 1245469019174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469019175 Walker A motif; other site 1245469019176 ATP binding site [chemical binding]; other site 1245469019177 Walker B motif; other site 1245469019178 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1245469019179 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1245469019180 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1245469019181 MOSC domain; Region: MOSC; pfam03473 1245469019182 TIGR02594 family protein; Region: TIGR02594 1245469019183 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469019184 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1245469019185 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1245469019186 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1245469019187 malate synthase G; Provisional; Region: PRK02999 1245469019188 active site 1245469019189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469019190 dimerization interface [polypeptide binding]; other site 1245469019191 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469019192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469019193 dimer interface [polypeptide binding]; other site 1245469019194 putative CheW interface [polypeptide binding]; other site 1245469019195 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 1245469019196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1245469019197 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1245469019198 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1245469019199 ATP-dependent helicase HepA; Validated; Region: PRK04914 1245469019200 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1245469019201 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1245469019202 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469019203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469019204 active site 1245469019205 phosphorylation site [posttranslational modification] 1245469019206 intermolecular recognition site; other site 1245469019207 dimerization interface [polypeptide binding]; other site 1245469019208 RNA polymerase sigma factor; Provisional; Region: PRK12540 1245469019209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1245469019210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1245469019211 DNA binding residues [nucleotide binding] 1245469019212 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 1245469019213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469019214 HWE histidine kinase; Region: HWE_HK; pfam07536 1245469019215 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469019216 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1245469019217 UreF; Region: UreF; pfam01730 1245469019218 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 1245469019219 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 1245469019220 dimer interface [polypeptide binding]; other site 1245469019221 catalytic residues [active] 1245469019222 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1245469019223 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1245469019224 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1245469019225 subunit interactions [polypeptide binding]; other site 1245469019226 active site 1245469019227 flap region; other site 1245469019228 HD domain; Region: HD_4; pfam13328 1245469019229 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1245469019230 gamma-beta subunit interface [polypeptide binding]; other site 1245469019231 alpha-beta subunit interface [polypeptide binding]; other site 1245469019232 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1245469019233 alpha-gamma subunit interface [polypeptide binding]; other site 1245469019234 beta-gamma subunit interface [polypeptide binding]; other site 1245469019235 UreD urease accessory protein; Region: UreD; pfam01774 1245469019236 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1245469019237 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469019238 Walker A/P-loop; other site 1245469019239 ATP binding site [chemical binding]; other site 1245469019240 Q-loop/lid; other site 1245469019241 ABC transporter signature motif; other site 1245469019242 Walker B; other site 1245469019243 D-loop; other site 1245469019244 H-loop/switch region; other site 1245469019245 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1245469019246 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469019247 Walker A/P-loop; other site 1245469019248 ATP binding site [chemical binding]; other site 1245469019249 Q-loop/lid; other site 1245469019250 ABC transporter signature motif; other site 1245469019251 Walker B; other site 1245469019252 D-loop; other site 1245469019253 H-loop/switch region; other site 1245469019254 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469019255 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469019256 TM-ABC transporter signature motif; other site 1245469019257 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469019258 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469019259 TM-ABC transporter signature motif; other site 1245469019260 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469019261 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1245469019262 putative ligand binding site [chemical binding]; other site 1245469019263 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1245469019264 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1245469019265 ATP binding site [chemical binding]; other site 1245469019266 Mg++ binding site [ion binding]; other site 1245469019267 motif III; other site 1245469019268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469019269 nucleotide binding region [chemical binding]; other site 1245469019270 ATP-binding site [chemical binding]; other site 1245469019271 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1245469019272 rRNA binding site [nucleotide binding]; other site 1245469019273 predicted 30S ribosome binding site; other site 1245469019274 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469019275 DNA-binding site [nucleotide binding]; DNA binding site 1245469019276 RNA-binding motif; other site 1245469019277 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1245469019278 TadE-like protein; Region: TadE; pfam07811 1245469019279 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1245469019280 TadE-like protein; Region: TadE; pfam07811 1245469019281 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1245469019282 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1245469019283 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1245469019284 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 1245469019285 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1245469019286 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1245469019287 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1245469019288 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1245469019289 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1245469019290 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469019291 Type IV pili component [Cell motility and secretion]; Region: COG5461 1245469019292 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 1245469019293 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1245469019294 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1245469019295 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1245469019296 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1245469019297 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1245469019298 ATP binding site [chemical binding]; other site 1245469019299 Walker A motif; other site 1245469019300 hexamer interface [polypeptide binding]; other site 1245469019301 Walker B motif; other site 1245469019302 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1245469019303 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469019304 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1245469019305 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1245469019306 allantoate amidohydrolase; Reviewed; Region: PRK12892 1245469019307 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1245469019308 active site 1245469019309 metal binding site [ion binding]; metal-binding site 1245469019310 dimer interface [polypeptide binding]; other site 1245469019311 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 1245469019312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469019313 TPR motif; other site 1245469019314 binding surface 1245469019315 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1245469019316 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1245469019317 interface (dimer of trimers) [polypeptide binding]; other site 1245469019318 Substrate-binding/catalytic site; other site 1245469019319 Zn-binding sites [ion binding]; other site 1245469019320 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1245469019321 NlpC/P60 family; Region: NLPC_P60; cl17555 1245469019322 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1245469019323 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469019324 Walker A/P-loop; other site 1245469019325 ATP binding site [chemical binding]; other site 1245469019326 Q-loop/lid; other site 1245469019327 ABC transporter signature motif; other site 1245469019328 Walker B; other site 1245469019329 D-loop; other site 1245469019330 H-loop/switch region; other site 1245469019331 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469019332 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469019333 Walker A/P-loop; other site 1245469019334 ATP binding site [chemical binding]; other site 1245469019335 Q-loop/lid; other site 1245469019336 ABC transporter signature motif; other site 1245469019337 Walker B; other site 1245469019338 D-loop; other site 1245469019339 H-loop/switch region; other site 1245469019340 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469019341 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1245469019342 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1245469019343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019344 dimer interface [polypeptide binding]; other site 1245469019345 conserved gate region; other site 1245469019346 ABC-ATPase subunit interface; other site 1245469019347 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1245469019348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019349 dimer interface [polypeptide binding]; other site 1245469019350 conserved gate region; other site 1245469019351 putative PBP binding loops; other site 1245469019352 ABC-ATPase subunit interface; other site 1245469019353 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1245469019354 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1245469019355 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1245469019356 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1245469019357 Cytochrome c; Region: Cytochrom_C; cl11414 1245469019358 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1245469019359 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1245469019360 Ligand binding site; other site 1245469019361 oligomer interface; other site 1245469019362 prephenate dehydratase; Provisional; Region: PRK11899 1245469019363 Prephenate dehydratase; Region: PDT; pfam00800 1245469019364 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1245469019365 putative L-Phe binding site [chemical binding]; other site 1245469019366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469019367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469019368 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469019369 putative effector binding pocket; other site 1245469019370 dimerization interface [polypeptide binding]; other site 1245469019371 NmrA-like family; Region: NmrA; pfam05368 1245469019372 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1245469019373 NADP binding site [chemical binding]; other site 1245469019374 active site 1245469019375 regulatory binding site [polypeptide binding]; other site 1245469019376 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1245469019377 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1245469019378 NAD binding site [chemical binding]; other site 1245469019379 substrate binding site [chemical binding]; other site 1245469019380 putative active site [active] 1245469019381 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1245469019382 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1245469019383 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1245469019384 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1245469019385 FAD binding site [chemical binding]; other site 1245469019386 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1245469019387 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1245469019388 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1245469019389 substrate binding pocket [chemical binding]; other site 1245469019390 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1245469019391 B12 binding site [chemical binding]; other site 1245469019392 cobalt ligand [ion binding]; other site 1245469019393 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1245469019394 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1245469019395 DevC protein; Region: devC; TIGR01185 1245469019396 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1245469019397 FtsX-like permease family; Region: FtsX; pfam02687 1245469019398 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1245469019399 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1245469019400 Walker A/P-loop; other site 1245469019401 ATP binding site [chemical binding]; other site 1245469019402 Q-loop/lid; other site 1245469019403 ABC transporter signature motif; other site 1245469019404 Walker B; other site 1245469019405 D-loop; other site 1245469019406 H-loop/switch region; other site 1245469019407 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1245469019408 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469019409 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1245469019410 C-terminal domain interface [polypeptide binding]; other site 1245469019411 GSH binding site (G-site) [chemical binding]; other site 1245469019412 dimer interface [polypeptide binding]; other site 1245469019413 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469019414 N-terminal domain interface [polypeptide binding]; other site 1245469019415 dimer interface [polypeptide binding]; other site 1245469019416 substrate binding pocket (H-site) [chemical binding]; other site 1245469019417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469019418 Coenzyme A binding pocket [chemical binding]; other site 1245469019419 glycerol kinase; Provisional; Region: glpK; PRK00047 1245469019420 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1245469019421 N- and C-terminal domain interface [polypeptide binding]; other site 1245469019422 active site 1245469019423 MgATP binding site [chemical binding]; other site 1245469019424 catalytic site [active] 1245469019425 metal binding site [ion binding]; metal-binding site 1245469019426 glycerol binding site [chemical binding]; other site 1245469019427 homotetramer interface [polypeptide binding]; other site 1245469019428 homodimer interface [polypeptide binding]; other site 1245469019429 FBP binding site [chemical binding]; other site 1245469019430 protein IIAGlc interface [polypeptide binding]; other site 1245469019431 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1245469019432 classical (c) SDRs; Region: SDR_c; cd05233 1245469019433 NAD(P) binding site [chemical binding]; other site 1245469019434 active site 1245469019435 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1245469019436 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1245469019437 active site 1245469019438 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1245469019439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469019440 active site 1245469019441 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1245469019442 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469019443 dimer interface [polypeptide binding]; other site 1245469019444 active site 1245469019445 dicarboxylate--CoA ligase PimA; Region: pimA; TIGR03205 1245469019446 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1245469019447 acyl-activating enzyme (AAE) consensus motif; other site 1245469019448 putative AMP binding site [chemical binding]; other site 1245469019449 putative active site [active] 1245469019450 putative CoA binding site [chemical binding]; other site 1245469019451 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469019452 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1245469019453 substrate binding site [chemical binding]; other site 1245469019454 oxyanion hole (OAH) forming residues; other site 1245469019455 trimer interface [polypeptide binding]; other site 1245469019456 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1245469019457 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469019458 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1245469019459 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1245469019460 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1245469019461 Bacterial transcriptional regulator; Region: IclR; pfam01614 1245469019462 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469019463 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469019464 Walker A/P-loop; other site 1245469019465 ATP binding site [chemical binding]; other site 1245469019466 Q-loop/lid; other site 1245469019467 ABC transporter signature motif; other site 1245469019468 Walker B; other site 1245469019469 D-loop; other site 1245469019470 H-loop/switch region; other site 1245469019471 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469019472 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469019473 Walker A/P-loop; other site 1245469019474 ATP binding site [chemical binding]; other site 1245469019475 Q-loop/lid; other site 1245469019476 ABC transporter signature motif; other site 1245469019477 Walker B; other site 1245469019478 D-loop; other site 1245469019479 H-loop/switch region; other site 1245469019480 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469019481 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469019482 TM-ABC transporter signature motif; other site 1245469019483 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469019484 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469019485 TM-ABC transporter signature motif; other site 1245469019486 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469019487 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469019488 putative ligand binding site [chemical binding]; other site 1245469019489 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469019490 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469019491 putative ligand binding site [chemical binding]; other site 1245469019492 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469019493 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469019494 putative ligand binding site [chemical binding]; other site 1245469019495 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1245469019496 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1245469019497 MOFRL family; Region: MOFRL; pfam05161 1245469019498 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469019499 MarR family; Region: MarR; pfam01047 1245469019500 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469019501 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469019502 TM-ABC transporter signature motif; other site 1245469019503 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469019504 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469019505 TM-ABC transporter signature motif; other site 1245469019506 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469019507 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469019508 Walker A/P-loop; other site 1245469019509 ATP binding site [chemical binding]; other site 1245469019510 Q-loop/lid; other site 1245469019511 ABC transporter signature motif; other site 1245469019512 Walker B; other site 1245469019513 D-loop; other site 1245469019514 H-loop/switch region; other site 1245469019515 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469019516 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469019517 Walker A/P-loop; other site 1245469019518 ATP binding site [chemical binding]; other site 1245469019519 Q-loop/lid; other site 1245469019520 ABC transporter signature motif; other site 1245469019521 Walker B; other site 1245469019522 D-loop; other site 1245469019523 H-loop/switch region; other site 1245469019524 quinate/shikimate dehydrogenase; Provisional; Region: PRK14027 1245469019525 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1245469019526 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1245469019527 shikimate binding site; other site 1245469019528 NAD(P) binding site [chemical binding]; other site 1245469019529 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1245469019530 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1245469019531 putative ligand binding site [chemical binding]; other site 1245469019532 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1245469019533 active site 1245469019534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1245469019535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469019536 NAD(P) binding site [chemical binding]; other site 1245469019537 active site 1245469019538 feruloyl-CoA synthase; Reviewed; Region: PRK08180 1245469019539 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1245469019540 acyl-activating enzyme (AAE) consensus motif; other site 1245469019541 putative AMP binding site [chemical binding]; other site 1245469019542 putative active site [active] 1245469019543 putative CoA binding site [chemical binding]; other site 1245469019544 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469019545 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469019546 substrate binding site [chemical binding]; other site 1245469019547 oxyanion hole (OAH) forming residues; other site 1245469019548 trimer interface [polypeptide binding]; other site 1245469019549 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 1245469019550 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1245469019551 P loop; other site 1245469019552 Nucleotide binding site [chemical binding]; other site 1245469019553 DTAP/Switch II; other site 1245469019554 Switch I; other site 1245469019555 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1245469019556 DTAP/Switch II; other site 1245469019557 Switch I; other site 1245469019558 hypothetical protein; Provisional; Region: PRK00872 1245469019559 DctM-like transporters; Region: DctM; pfam06808 1245469019560 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469019561 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1245469019562 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469019563 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469019564 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1245469019565 CoenzymeA binding site [chemical binding]; other site 1245469019566 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1245469019567 subunit interaction site [polypeptide binding]; other site 1245469019568 PHB binding site; other site 1245469019569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469019570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469019571 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 1245469019572 putative effector binding pocket; other site 1245469019573 putative dimerization interface [polypeptide binding]; other site 1245469019574 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1245469019575 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469019576 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469019577 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 1245469019578 putative N-terminal domain interface [polypeptide binding]; other site 1245469019579 Predicted transcriptional regulator [Transcription]; Region: COG2378 1245469019580 HTH domain; Region: HTH_11; pfam08279 1245469019581 WYL domain; Region: WYL; pfam13280 1245469019582 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1245469019583 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 1245469019584 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 1245469019585 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469019586 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469019587 ligand binding site [chemical binding]; other site 1245469019588 flexible hinge region; other site 1245469019589 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469019590 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469019591 substrate binding site [chemical binding]; other site 1245469019592 oxyanion hole (OAH) forming residues; other site 1245469019593 trimer interface [polypeptide binding]; other site 1245469019594 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 1245469019595 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1245469019596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469019597 DNA binding residues [nucleotide binding] 1245469019598 dimerization interface [polypeptide binding]; other site 1245469019599 Autoinducer synthetase; Region: Autoind_synth; cl17404 1245469019600 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 1245469019601 putative FMN binding site [chemical binding]; other site 1245469019602 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469019603 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1245469019604 FAD binding site [chemical binding]; other site 1245469019605 substrate binding site [chemical binding]; other site 1245469019606 catalytic base [active] 1245469019607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469019608 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1245469019609 FAD binding site [chemical binding]; other site 1245469019610 substrate binding site [chemical binding]; other site 1245469019611 catalytic base [active] 1245469019612 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469019613 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469019614 active site 1245469019615 acyl-CoA synthetase; Provisional; Region: PRK12582 1245469019616 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 1245469019617 acyl-activating enzyme (AAE) consensus motif; other site 1245469019618 putative AMP binding site [chemical binding]; other site 1245469019619 putative active site [active] 1245469019620 putative CoA binding site [chemical binding]; other site 1245469019621 enoyl-CoA hydratase; Provisional; Region: PRK06688 1245469019622 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469019623 substrate binding site [chemical binding]; other site 1245469019624 oxyanion hole (OAH) forming residues; other site 1245469019625 trimer interface [polypeptide binding]; other site 1245469019626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469019627 NAD(P) binding site [chemical binding]; other site 1245469019628 active site 1245469019629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469019630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469019631 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 1245469019632 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469019633 dimer interface [polypeptide binding]; other site 1245469019634 active site 1245469019635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469019636 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1245469019637 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469019638 acyl-activating enzyme (AAE) consensus motif; other site 1245469019639 putative AMP binding site [chemical binding]; other site 1245469019640 putative active site [active] 1245469019641 putative CoA binding site [chemical binding]; other site 1245469019642 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469019643 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469019644 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1245469019645 diiron binding motif [ion binding]; other site 1245469019646 Uncharacterized conserved protein [Function unknown]; Region: COG1633 1245469019647 CCC1-related family of proteins; Region: CCC1_like; cl00278 1245469019648 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1245469019649 amidase; Provisional; Region: PRK06170 1245469019650 Amidase; Region: Amidase; cl11426 1245469019651 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1245469019652 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1245469019653 NAD binding site [chemical binding]; other site 1245469019654 catalytic Zn binding site [ion binding]; other site 1245469019655 substrate binding site [chemical binding]; other site 1245469019656 structural Zn binding site [ion binding]; other site 1245469019657 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469019658 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469019659 active site 1245469019660 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1245469019661 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1245469019662 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 1245469019663 N-terminal domain interface [polypeptide binding]; other site 1245469019664 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1245469019665 classical (c) SDR, subgroup 10; Region: SDR_c10; cd05373 1245469019666 putative NAD(P) binding site [chemical binding]; other site 1245469019667 active site 1245469019668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1245469019669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469019670 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 1245469019671 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1245469019672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469019673 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1245469019674 dimerization interface [polypeptide binding]; other site 1245469019675 substrate binding pocket [chemical binding]; other site 1245469019676 citrate-proton symporter; Provisional; Region: PRK15075 1245469019677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469019678 putative substrate translocation pore; other site 1245469019679 Competence-damaged protein; Region: CinA; pfam02464 1245469019680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1245469019681 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1245469019682 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469019683 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469019684 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 1245469019685 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1245469019686 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 1245469019687 Walker A/P-loop; other site 1245469019688 ATP binding site [chemical binding]; other site 1245469019689 Q-loop/lid; other site 1245469019690 ABC transporter signature motif; other site 1245469019691 Walker B; other site 1245469019692 D-loop; other site 1245469019693 H-loop/switch region; other site 1245469019694 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1245469019695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469019696 Walker B; other site 1245469019697 D-loop; other site 1245469019698 H-loop/switch region; other site 1245469019699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469019700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469019701 Amidase; Region: Amidase; cl11426 1245469019702 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1245469019703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469019704 Walker A/P-loop; other site 1245469019705 ATP binding site [chemical binding]; other site 1245469019706 Q-loop/lid; other site 1245469019707 ABC transporter signature motif; other site 1245469019708 Walker B; other site 1245469019709 D-loop; other site 1245469019710 H-loop/switch region; other site 1245469019711 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1245469019712 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469019713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019714 dimer interface [polypeptide binding]; other site 1245469019715 conserved gate region; other site 1245469019716 putative PBP binding loops; other site 1245469019717 ABC-ATPase subunit interface; other site 1245469019718 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469019719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019720 dimer interface [polypeptide binding]; other site 1245469019721 conserved gate region; other site 1245469019722 putative PBP binding loops; other site 1245469019723 ABC-ATPase subunit interface; other site 1245469019724 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469019725 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 1245469019726 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 1245469019727 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469019728 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1245469019729 CHASE2 domain; Region: CHASE2; pfam05226 1245469019730 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469019731 cyclase homology domain; Region: CHD; cd07302 1245469019732 nucleotidyl binding site; other site 1245469019733 metal binding site [ion binding]; metal-binding site 1245469019734 dimer interface [polypeptide binding]; other site 1245469019735 FecR protein; Region: FecR; pfam04773 1245469019736 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 1245469019737 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1245469019738 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1245469019739 Amidase; Region: Amidase; cl11426 1245469019740 Outer membrane efflux protein; Region: OEP; pfam02321 1245469019741 Outer membrane efflux protein; Region: OEP; pfam02321 1245469019742 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1245469019743 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1245469019744 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469019745 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1245469019746 CHAT domain; Region: CHAT; pfam12770 1245469019747 AAA ATPase domain; Region: AAA_16; pfam13191 1245469019748 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 1245469019749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1245469019750 MarR family; Region: MarR_2; cl17246 1245469019751 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469019752 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1245469019753 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1245469019754 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1245469019755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469019756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1245469019757 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1245469019758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019759 dimer interface [polypeptide binding]; other site 1245469019760 conserved gate region; other site 1245469019761 putative PBP binding loops; other site 1245469019762 ABC-ATPase subunit interface; other site 1245469019763 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469019764 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1245469019765 Walker A/P-loop; other site 1245469019766 ATP binding site [chemical binding]; other site 1245469019767 Q-loop/lid; other site 1245469019768 ABC transporter signature motif; other site 1245469019769 Walker B; other site 1245469019770 D-loop; other site 1245469019771 H-loop/switch region; other site 1245469019772 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1245469019773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469019774 Walker A/P-loop; other site 1245469019775 ATP binding site [chemical binding]; other site 1245469019776 Q-loop/lid; other site 1245469019777 ABC transporter signature motif; other site 1245469019778 Walker B; other site 1245469019779 D-loop; other site 1245469019780 H-loop/switch region; other site 1245469019781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469019782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469019783 NAD(P) binding site [chemical binding]; other site 1245469019784 active site 1245469019785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469019786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1245469019787 active site 1245469019788 metal binding site [ion binding]; metal-binding site 1245469019789 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469019790 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469019791 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1245469019792 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1245469019793 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 1245469019794 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 1245469019795 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1245469019796 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1245469019797 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469019798 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1245469019799 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1245469019800 Walker A/P-loop; other site 1245469019801 ATP binding site [chemical binding]; other site 1245469019802 Q-loop/lid; other site 1245469019803 ABC transporter signature motif; other site 1245469019804 Walker B; other site 1245469019805 D-loop; other site 1245469019806 H-loop/switch region; other site 1245469019807 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1245469019808 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1245469019809 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1245469019810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469019811 Walker A/P-loop; other site 1245469019812 ATP binding site [chemical binding]; other site 1245469019813 Q-loop/lid; other site 1245469019814 ABC transporter signature motif; other site 1245469019815 Walker B; other site 1245469019816 D-loop; other site 1245469019817 H-loop/switch region; other site 1245469019818 TOBE domain; Region: TOBE_2; pfam08402 1245469019819 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1245469019820 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1245469019821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019822 dimer interface [polypeptide binding]; other site 1245469019823 conserved gate region; other site 1245469019824 putative PBP binding loops; other site 1245469019825 ABC-ATPase subunit interface; other site 1245469019826 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1245469019827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469019828 dimer interface [polypeptide binding]; other site 1245469019829 conserved gate region; other site 1245469019830 putative PBP binding loops; other site 1245469019831 ABC-ATPase subunit interface; other site 1245469019832 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1245469019833 active site 1245469019834 homotetramer interface [polypeptide binding]; other site 1245469019835 amidase; Provisional; Region: PRK07487 1245469019836 Amidase; Region: Amidase; cl11426 1245469019837 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 1245469019838 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 1245469019839 active site 1245469019840 catalytic site [active] 1245469019841 tetramer interface [polypeptide binding]; other site 1245469019842 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 1245469019843 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1245469019844 active site 1245469019845 homotetramer interface [polypeptide binding]; other site 1245469019846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1245469019847 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 1245469019848 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 1245469019849 dimer interface [polypeptide binding]; other site 1245469019850 active site 1245469019851 catalytic residue [active] 1245469019852 metal binding site [ion binding]; metal-binding site 1245469019853 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1245469019854 dimer interface [polypeptide binding]; other site 1245469019855 substrate binding site [chemical binding]; other site 1245469019856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469019857 metal binding site [ion binding]; metal-binding site 1245469019858 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1245469019859 DctM-like transporters; Region: DctM; pfam06808 1245469019860 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1245469019861 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469019862 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1245469019863 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1245469019864 DNA binding site [nucleotide binding] 1245469019865 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1245469019866 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1245469019867 putative ligand binding site [chemical binding]; other site 1245469019868 transcriptional regulator; Provisional; Region: PRK10632 1245469019869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469019870 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1245469019871 putative effector binding pocket; other site 1245469019872 dimerization interface [polypeptide binding]; other site 1245469019873 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1245469019874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469019875 Zn binding site [ion binding]; other site 1245469019876 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1245469019877 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469019878 Zn binding site [ion binding]; other site 1245469019879 putative hydrolase; Provisional; Region: PRK11460 1245469019880 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1245469019881 cytosine deaminase; Provisional; Region: PRK05985 1245469019882 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1245469019883 active site 1245469019884 carboxylate-amine ligase; Provisional; Region: PRK13515 1245469019885 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1245469019886 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1245469019887 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1245469019888 active site 1245469019889 dimer interface [polypeptide binding]; other site 1245469019890 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1245469019891 Ligand Binding Site [chemical binding]; other site 1245469019892 Molecular Tunnel; other site 1245469019893 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1245469019894 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1245469019895 putative active site [active] 1245469019896 putative dimer interface [polypeptide binding]; other site 1245469019897 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1245469019898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469019899 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1245469019900 putative dimerization interface [polypeptide binding]; other site 1245469019901 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1245469019902 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1245469019903 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1245469019904 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1245469019905 catalytic triad [active] 1245469019906 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469019907 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469019908 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469019909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1245469019910 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1245469019911 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1245469019912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1245469019913 motif II; other site 1245469019914 hypothetical protein; Provisional; Region: PRK01254 1245469019915 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1245469019916 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1245469019917 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 1245469019918 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1245469019919 iron-sulfur cluster [ion binding]; other site 1245469019920 [2Fe-2S] cluster binding site [ion binding]; other site 1245469019921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1245469019922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1245469019923 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1245469019924 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1245469019925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469019926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469019927 putative substrate translocation pore; other site 1245469019928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469019929 binding surface 1245469019930 TPR motif; other site 1245469019931 TPR repeat; Region: TPR_11; pfam13414 1245469019932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469019933 binding surface 1245469019934 TPR motif; other site 1245469019935 TPR repeat; Region: TPR_11; pfam13414 1245469019936 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469019937 binding surface 1245469019938 TPR motif; other site 1245469019939 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469019940 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469019941 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469019942 active site 1245469019943 catalytic tetrad [active] 1245469019944 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1245469019945 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 1245469019946 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469019947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469019948 dimer interface [polypeptide binding]; other site 1245469019949 phosphorylation site [posttranslational modification] 1245469019950 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1245469019951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469019952 ATP binding site [chemical binding]; other site 1245469019953 Mg2+ binding site [ion binding]; other site 1245469019954 G-X-G motif; other site 1245469019955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469019956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469019957 active site 1245469019958 phosphorylation site [posttranslational modification] 1245469019959 intermolecular recognition site; other site 1245469019960 dimerization interface [polypeptide binding]; other site 1245469019961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469019962 DNA binding site [nucleotide binding] 1245469019963 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1245469019964 Flagellar L-ring protein; Region: FlgH; cl17277 1245469019965 Peptidase family M48; Region: Peptidase_M48; cl12018 1245469019966 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1245469019967 TIGR04222 domain; Region: near_uncomplex 1245469019968 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1245469019969 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1245469019970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469019971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469019972 homodimer interface [polypeptide binding]; other site 1245469019973 catalytic residue [active] 1245469019974 hypothetical protein; Provisional; Region: PRK02395 1245469019975 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1245469019976 putative active site [active] 1245469019977 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1245469019978 putative active site [active] 1245469019979 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469019980 Cytochrome c; Region: Cytochrom_C; pfam00034 1245469019981 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1245469019982 heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051 1245469019983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1245469019984 FeS/SAM binding site; other site 1245469019985 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1245469019986 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469019987 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1245469019988 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469019989 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469019990 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469019991 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1245469019992 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469019993 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1245469019994 active site 1245469019995 SAM binding site [chemical binding]; other site 1245469019996 homodimer interface [polypeptide binding]; other site 1245469019997 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1245469019998 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1245469019999 Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239 1245469020000 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 1245469020001 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1245469020002 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1245469020003 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1245469020004 ApbE family; Region: ApbE; pfam02424 1245469020005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469020006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469020007 ligand binding site [chemical binding]; other site 1245469020008 flexible hinge region; other site 1245469020009 putative protease; Provisional; Region: PRK15447 1245469020010 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1245469020011 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1245469020012 Peptidase family U32; Region: Peptidase_U32; pfam01136 1245469020013 SCP-2 sterol transfer family; Region: SCP2; cl01225 1245469020014 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1245469020015 Flavoprotein; Region: Flavoprotein; pfam02441 1245469020016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469020017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469020018 ATP binding site [chemical binding]; other site 1245469020019 Mg2+ binding site [ion binding]; other site 1245469020020 G-X-G motif; other site 1245469020021 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 1245469020022 Ribonuclease P; Region: Ribonuclease_P; cl00457 1245469020023 membrane protein insertase; Provisional; Region: PRK01318 1245469020024 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 1245469020025 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1245469020026 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1245469020027 G1 box; other site 1245469020028 GTP/Mg2+ binding site [chemical binding]; other site 1245469020029 Switch I region; other site 1245469020030 G2 box; other site 1245469020031 G3 box; other site 1245469020032 Switch II region; other site 1245469020033 G4 box; other site 1245469020034 G5 box; other site 1245469020035 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1245469020036 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1245469020037 feedback inhibition sensing region; other site 1245469020038 homohexameric interface [polypeptide binding]; other site 1245469020039 nucleotide binding site [chemical binding]; other site 1245469020040 N-acetyl-L-glutamate binding site [chemical binding]; other site 1245469020041 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 1245469020042 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1245469020043 Protein of unknown function (DUF1036); Region: DUF1036; pfam06282 1245469020044 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 1245469020045 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1245469020046 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1245469020047 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1245469020048 trimer interface [polypeptide binding]; other site 1245469020049 active site 1245469020050 substrate binding site [chemical binding]; other site 1245469020051 CoA binding site [chemical binding]; other site 1245469020052 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1245469020053 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1245469020054 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1245469020055 metal binding site [ion binding]; metal-binding site 1245469020056 dimer interface [polypeptide binding]; other site 1245469020057 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1245469020058 homotrimer interaction site [polypeptide binding]; other site 1245469020059 putative active site [active] 1245469020060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469020061 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469020062 dimer interface [polypeptide binding]; other site 1245469020063 putative CheW interface [polypeptide binding]; other site 1245469020064 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1245469020065 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1245469020066 dimerization interface 3.5A [polypeptide binding]; other site 1245469020067 active site 1245469020068 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1245469020069 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1245469020070 putative active site [active] 1245469020071 substrate binding site [chemical binding]; other site 1245469020072 putative cosubstrate binding site; other site 1245469020073 catalytic site [active] 1245469020074 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1245469020075 substrate binding site [chemical binding]; other site 1245469020076 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1245469020077 active site 1245469020078 catalytic residues [active] 1245469020079 metal binding site [ion binding]; metal-binding site 1245469020080 RmuC family; Region: RmuC; pfam02646 1245469020081 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1245469020082 GIY-YIG motif/motif A; other site 1245469020083 putative active site [active] 1245469020084 putative metal binding site [ion binding]; other site 1245469020085 muropeptide transporter; Validated; Region: ampG; cl17669 1245469020086 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1245469020087 recombination protein RecR; Reviewed; Region: recR; PRK00076 1245469020088 RecR protein; Region: RecR; pfam02132 1245469020089 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1245469020090 tetramer interface [polypeptide binding]; other site 1245469020091 putative active site [active] 1245469020092 putative metal-binding site [ion binding]; other site 1245469020093 hypothetical protein; Validated; Region: PRK00153 1245469020094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 1245469020095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469020096 Walker A motif; other site 1245469020097 ATP binding site [chemical binding]; other site 1245469020098 Walker B motif; other site 1245469020099 arginine finger; other site 1245469020100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1245469020101 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 1245469020102 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1245469020103 nucleotide binding site/active site [active] 1245469020104 HIT family signature motif; other site 1245469020105 catalytic residue [active] 1245469020106 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1245469020107 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1245469020108 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1245469020109 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1245469020110 putative NADH binding site [chemical binding]; other site 1245469020111 putative active site [active] 1245469020112 nudix motif; other site 1245469020113 putative metal binding site [ion binding]; other site 1245469020114 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1245469020115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469020116 dimerization interface [polypeptide binding]; other site 1245469020117 putative DNA binding site [nucleotide binding]; other site 1245469020118 putative Zn2+ binding site [ion binding]; other site 1245469020119 AsnC family; Region: AsnC_trans_reg; pfam01037 1245469020120 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1245469020121 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469020122 dimer interface [polypeptide binding]; other site 1245469020123 putative CheW interface [polypeptide binding]; other site 1245469020124 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1245469020125 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1245469020126 active site 1245469020127 substrate binding site [chemical binding]; other site 1245469020128 metal binding site [ion binding]; metal-binding site 1245469020129 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1245469020130 catalytic motif [active] 1245469020131 Catalytic residue [active] 1245469020132 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1245469020133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469020134 ATP binding site [chemical binding]; other site 1245469020135 putative Mg++ binding site [ion binding]; other site 1245469020136 nucleotide binding region [chemical binding]; other site 1245469020137 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1245469020138 ATP-binding site [chemical binding]; other site 1245469020139 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1245469020140 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1245469020141 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1245469020142 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1245469020143 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1245469020144 Predicted membrane protein [Function unknown]; Region: COG4763 1245469020145 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1245469020146 5'-3' exonuclease; Region: 53EXOc; smart00475 1245469020147 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1245469020148 active site 1245469020149 metal binding site 1 [ion binding]; metal-binding site 1245469020150 putative 5' ssDNA interaction site; other site 1245469020151 metal binding site 3; metal-binding site 1245469020152 metal binding site 2 [ion binding]; metal-binding site 1245469020153 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1245469020154 putative DNA binding site [nucleotide binding]; other site 1245469020155 putative metal binding site [ion binding]; other site 1245469020156 DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749 1245469020157 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1245469020158 active site 1245469020159 catalytic site [active] 1245469020160 substrate binding site [chemical binding]; other site 1245469020161 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1245469020162 active site 1245469020163 DNA binding site [nucleotide binding] 1245469020164 catalytic site [active] 1245469020165 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1245469020166 hypothetical protein; Validated; Region: PRK06201 1245469020167 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1245469020168 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469020169 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469020170 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1245469020171 dimerization interface [polypeptide binding]; other site 1245469020172 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469020173 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1245469020174 substrate binding pocket [chemical binding]; other site 1245469020175 membrane-bound complex binding site; other site 1245469020176 hinge residues; other site 1245469020177 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1245469020178 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1245469020179 N-terminal domain interface [polypeptide binding]; other site 1245469020180 dimer interface [polypeptide binding]; other site 1245469020181 substrate binding pocket (H-site) [chemical binding]; other site 1245469020182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469020183 active site 1245469020184 Protein of unknown function (DUF2865); Region: DUF2865; pfam11064 1245469020185 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1245469020186 homodimer interface [polypeptide binding]; other site 1245469020187 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1245469020188 active site pocket [active] 1245469020189 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1245469020190 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1245469020191 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1245469020192 active site 1245469020193 substrate-binding site [chemical binding]; other site 1245469020194 metal-binding site [ion binding] 1245469020195 ATP binding site [chemical binding]; other site 1245469020196 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 1245469020197 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 1245469020198 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1245469020199 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469020200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469020201 active site 1245469020202 phosphorylation site [posttranslational modification] 1245469020203 intermolecular recognition site; other site 1245469020204 dimerization interface [polypeptide binding]; other site 1245469020205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469020206 DNA binding site [nucleotide binding] 1245469020207 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 1245469020208 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 1245469020209 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469020210 HAMP domain; Region: HAMP; pfam00672 1245469020211 dimerization interface [polypeptide binding]; other site 1245469020212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469020213 dimer interface [polypeptide binding]; other site 1245469020214 phosphorylation site [posttranslational modification] 1245469020215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469020216 ATP binding site [chemical binding]; other site 1245469020217 Mg2+ binding site [ion binding]; other site 1245469020218 G-X-G motif; other site 1245469020219 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1245469020220 Hpr binding site; other site 1245469020221 active site 1245469020222 homohexamer subunit interaction site [polypeptide binding]; other site 1245469020223 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1245469020224 active pocket/dimerization site; other site 1245469020225 active site 1245469020226 phosphorylation site [posttranslational modification] 1245469020227 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1245469020228 dimerization domain swap beta strand [polypeptide binding]; other site 1245469020229 regulatory protein interface [polypeptide binding]; other site 1245469020230 active site 1245469020231 regulatory phosphorylation site [posttranslational modification]; other site 1245469020232 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1245469020233 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469020234 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1245469020235 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1245469020236 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1245469020237 GTP-binding protein LepA; Provisional; Region: PRK05433 1245469020238 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1245469020239 G1 box; other site 1245469020240 putative GEF interaction site [polypeptide binding]; other site 1245469020241 GTP/Mg2+ binding site [chemical binding]; other site 1245469020242 Switch I region; other site 1245469020243 G2 box; other site 1245469020244 G3 box; other site 1245469020245 Switch II region; other site 1245469020246 G4 box; other site 1245469020247 G5 box; other site 1245469020248 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1245469020249 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1245469020250 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1245469020251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1245469020252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1245469020253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1245469020254 dimerization interface [polypeptide binding]; other site 1245469020255 PAS domain; Region: PAS; smart00091 1245469020256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469020257 DNA binding residues [nucleotide binding] 1245469020258 dimerization interface [polypeptide binding]; other site 1245469020259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469020260 dimerization interface [polypeptide binding]; other site 1245469020261 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469020262 dimer interface [polypeptide binding]; other site 1245469020263 putative CheW interface [polypeptide binding]; other site 1245469020264 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1245469020265 active site residue [active] 1245469020266 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1245469020267 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1245469020268 conserved cys residue [active] 1245469020269 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1245469020270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469020271 PAS fold; Region: PAS_7; pfam12860 1245469020272 PAS domain S-box; Region: sensory_box; TIGR00229 1245469020273 PAS domain; Region: PAS_8; pfam13188 1245469020274 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469020275 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469020276 metal binding site [ion binding]; metal-binding site 1245469020277 active site 1245469020278 I-site; other site 1245469020279 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469020280 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1245469020281 potassium/proton antiporter; Reviewed; Region: PRK05326 1245469020282 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1245469020283 Transporter associated domain; Region: CorC_HlyC; smart01091 1245469020284 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1245469020285 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1245469020286 active site 1245469020287 catalytic residues [active] 1245469020288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469020289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1245469020290 active site 1245469020291 phosphorylation site [posttranslational modification] 1245469020292 intermolecular recognition site; other site 1245469020293 dimerization interface [polypeptide binding]; other site 1245469020294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469020295 DNA binding residues [nucleotide binding] 1245469020296 dimerization interface [polypeptide binding]; other site 1245469020297 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1245469020298 active site 1245469020299 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 1245469020300 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1245469020301 putative active site [active] 1245469020302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469020303 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469020304 putative substrate translocation pore; other site 1245469020305 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1245469020306 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1245469020307 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469020308 hypothetical protein; Reviewed; Region: PRK00024 1245469020309 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1245469020310 MPN+ (JAMM) motif; other site 1245469020311 Zinc-binding site [ion binding]; other site 1245469020312 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 1245469020313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1245469020314 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1245469020315 active site 1245469020316 DNA binding site [nucleotide binding] 1245469020317 Int/Topo IB signature motif; other site 1245469020318 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1245469020319 Family description; Region: UvrD_C_2; pfam13538 1245469020320 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1245469020321 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 1245469020322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1245469020323 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1245469020324 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1245469020325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469020326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1245469020327 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1245469020328 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1245469020329 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1245469020330 potential catalytic triad [active] 1245469020331 conserved cys residue [active] 1245469020332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469020333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469020334 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469020335 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1245469020336 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1245469020337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1245469020338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1245469020339 active site 1245469020340 catalytic tetrad [active] 1245469020341 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1245469020342 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1245469020343 DNA binding site [nucleotide binding] 1245469020344 Predicted ATPase [General function prediction only]; Region: COG3903 1245469020345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1245469020346 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1245469020347 MPN+ (JAMM) motif; other site 1245469020348 Zinc-binding site [ion binding]; other site 1245469020349 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1245469020350 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1245469020351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469020352 DNA-binding site [nucleotide binding]; DNA binding site 1245469020353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1245469020354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1245469020355 homodimer interface [polypeptide binding]; other site 1245469020356 catalytic residue [active] 1245469020357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469020358 dimerization interface [polypeptide binding]; other site 1245469020359 PAS fold; Region: PAS_7; pfam12860 1245469020360 PAS domain; Region: PAS; smart00091 1245469020361 PAS domain; Region: PAS_9; pfam13426 1245469020362 TIGR03032 family protein; Region: TIGR03032 1245469020363 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1245469020364 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1245469020365 putative ligand binding site [chemical binding]; other site 1245469020366 NAD binding site [chemical binding]; other site 1245469020367 catalytic site [active] 1245469020368 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469020369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020370 dimer interface [polypeptide binding]; other site 1245469020371 conserved gate region; other site 1245469020372 ABC-ATPase subunit interface; other site 1245469020373 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469020374 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469020375 Walker A/P-loop; other site 1245469020376 ATP binding site [chemical binding]; other site 1245469020377 Q-loop/lid; other site 1245469020378 ABC transporter signature motif; other site 1245469020379 Walker B; other site 1245469020380 D-loop; other site 1245469020381 H-loop/switch region; other site 1245469020382 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1245469020383 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469020384 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1245469020385 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469020386 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 1245469020387 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1245469020388 Domain of unknown function DUF21; Region: DUF21; pfam01595 1245469020389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1245469020390 Transporter associated domain; Region: CorC_HlyC; smart01091 1245469020391 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1245469020392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020393 dimer interface [polypeptide binding]; other site 1245469020394 conserved gate region; other site 1245469020395 putative PBP binding loops; other site 1245469020396 ABC-ATPase subunit interface; other site 1245469020397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020398 dimer interface [polypeptide binding]; other site 1245469020399 ABC-ATPase subunit interface; other site 1245469020400 putative PBP binding loops; other site 1245469020401 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469020402 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469020403 Walker A/P-loop; other site 1245469020404 ATP binding site [chemical binding]; other site 1245469020405 Q-loop/lid; other site 1245469020406 ABC transporter signature motif; other site 1245469020407 Walker B; other site 1245469020408 D-loop; other site 1245469020409 H-loop/switch region; other site 1245469020410 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1245469020411 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1245469020412 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1245469020413 active site 1245469020414 FMN binding site [chemical binding]; other site 1245469020415 substrate binding site [chemical binding]; other site 1245469020416 3Fe-4S cluster binding site [ion binding]; other site 1245469020417 acyl-CoA synthetase; Validated; Region: PRK08316 1245469020418 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469020419 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1245469020420 acyl-activating enzyme (AAE) consensus motif; other site 1245469020421 acyl-activating enzyme (AAE) consensus motif; other site 1245469020422 putative AMP binding site [chemical binding]; other site 1245469020423 putative active site [active] 1245469020424 putative CoA binding site [chemical binding]; other site 1245469020425 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1245469020426 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1245469020427 FAD binding pocket [chemical binding]; other site 1245469020428 FAD binding motif [chemical binding]; other site 1245469020429 phosphate binding motif [ion binding]; other site 1245469020430 beta-alpha-beta structure motif; other site 1245469020431 NAD binding pocket [chemical binding]; other site 1245469020432 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1245469020433 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 1245469020434 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469020435 substrate binding pocket [chemical binding]; other site 1245469020436 membrane-bound complex binding site; other site 1245469020437 hinge residues; other site 1245469020438 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1245469020439 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1245469020440 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469020441 hypothetical protein; Provisional; Region: PRK06847 1245469020442 hypothetical protein; Provisional; Region: PRK07236 1245469020443 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469020444 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 1245469020445 acyl-activating enzyme (AAE) consensus motif; other site 1245469020446 AMP binding site [chemical binding]; other site 1245469020447 active site 1245469020448 CoA binding site [chemical binding]; other site 1245469020449 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469020450 MarR family; Region: MarR_2; pfam12802 1245469020451 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1245469020452 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1245469020453 C-terminal domain interface [polypeptide binding]; other site 1245469020454 GSH binding site (G-site) [chemical binding]; other site 1245469020455 putative dimer interface [polypeptide binding]; other site 1245469020456 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1245469020457 dimer interface [polypeptide binding]; other site 1245469020458 N-terminal domain interface [polypeptide binding]; other site 1245469020459 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1245469020460 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 1245469020461 Cupin domain; Region: Cupin_2; pfam07883 1245469020462 Cupin domain; Region: Cupin_2; cl17218 1245469020463 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469020464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020465 dimer interface [polypeptide binding]; other site 1245469020466 conserved gate region; other site 1245469020467 putative PBP binding loops; other site 1245469020468 ABC-ATPase subunit interface; other site 1245469020469 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469020470 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469020471 Walker A/P-loop; other site 1245469020472 ATP binding site [chemical binding]; other site 1245469020473 Q-loop/lid; other site 1245469020474 ABC transporter signature motif; other site 1245469020475 Walker B; other site 1245469020476 D-loop; other site 1245469020477 H-loop/switch region; other site 1245469020478 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1245469020479 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1245469020480 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469020481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469020482 dimerization interface [polypeptide binding]; other site 1245469020483 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469020484 dimer interface [polypeptide binding]; other site 1245469020485 putative CheW interface [polypeptide binding]; other site 1245469020486 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469020487 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469020488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469020489 dimerization interface [polypeptide binding]; other site 1245469020490 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469020491 dimer interface [polypeptide binding]; other site 1245469020492 putative CheW interface [polypeptide binding]; other site 1245469020493 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1245469020494 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1245469020495 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1245469020496 dimerization interface [polypeptide binding]; other site 1245469020497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1245469020498 dimer interface [polypeptide binding]; other site 1245469020499 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1245469020500 putative CheW interface [polypeptide binding]; other site 1245469020501 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1245469020502 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 1245469020503 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1245469020504 NAD binding site [chemical binding]; other site 1245469020505 active site 1245469020506 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1245469020507 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1245469020508 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1245469020509 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1245469020510 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1245469020511 RNA binding site [nucleotide binding]; other site 1245469020512 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1245469020513 Part of AAA domain; Region: AAA_19; pfam13245 1245469020514 Family description; Region: UvrD_C_2; pfam13538 1245469020515 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 1245469020516 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1245469020517 putative di-iron ligands [ion binding]; other site 1245469020518 hypothetical protein; Validated; Region: PRK07581 1245469020519 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1245469020520 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1245469020521 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1245469020522 TPR repeat; Region: TPR_11; pfam13414 1245469020523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469020524 binding surface 1245469020525 TPR motif; other site 1245469020526 TPR repeat; Region: TPR_11; pfam13414 1245469020527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469020528 binding surface 1245469020529 TPR motif; other site 1245469020530 TPR repeat; Region: TPR_11; pfam13414 1245469020531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469020532 binding surface 1245469020533 TPR motif; other site 1245469020534 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1245469020535 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1245469020536 active site 1245469020537 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 1245469020538 Autotransporter beta-domain; Region: Autotransporter; smart00869 1245469020539 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1245469020540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469020541 S-adenosylmethionine binding site [chemical binding]; other site 1245469020542 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1245469020543 Peptidase family M28; Region: Peptidase_M28; pfam04389 1245469020544 metal binding site [ion binding]; metal-binding site 1245469020545 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1245469020546 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1245469020547 Predicted membrane protein [Function unknown]; Region: COG2261 1245469020548 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1245469020549 classical (c) SDRs; Region: SDR_c; cd05233 1245469020550 NAD(P) binding site [chemical binding]; other site 1245469020551 active site 1245469020552 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469020553 active site 1245469020554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1245469020555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469020556 active site 1245469020557 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1245469020558 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469020559 substrate binding site [chemical binding]; other site 1245469020560 oxyanion hole (OAH) forming residues; other site 1245469020561 trimer interface [polypeptide binding]; other site 1245469020562 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1245469020563 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1245469020564 active site 1245469020565 metal binding site [ion binding]; metal-binding site 1245469020566 enoyl-CoA hydratase; Provisional; Region: PRK06688 1245469020567 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1245469020568 substrate binding site [chemical binding]; other site 1245469020569 oxyanion hole (OAH) forming residues; other site 1245469020570 trimer interface [polypeptide binding]; other site 1245469020571 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469020572 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 1245469020573 putative ligand binding site [chemical binding]; other site 1245469020574 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 1245469020575 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 1245469020576 Peptidase family M48; Region: Peptidase_M48; pfam01435 1245469020577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1245469020578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469020579 short chain dehydrogenase; Provisional; Region: PRK12939 1245469020580 NAD(P) binding site [chemical binding]; other site 1245469020581 active site 1245469020582 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1245469020583 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1245469020584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469020585 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1245469020586 Ferredoxin [Energy production and conversion]; Region: COG1146 1245469020587 4Fe-4S binding domain; Region: Fer4; pfam00037 1245469020588 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1245469020589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1245469020590 RNA binding surface [nucleotide binding]; other site 1245469020591 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1245469020592 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1245469020593 ATP binding site [chemical binding]; other site 1245469020594 putative Mg++ binding site [ion binding]; other site 1245469020595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469020596 nucleotide binding region [chemical binding]; other site 1245469020597 ATP-binding site [chemical binding]; other site 1245469020598 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1245469020599 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1245469020600 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1245469020601 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1245469020602 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1245469020603 DNA-binding site [nucleotide binding]; DNA binding site 1245469020604 RNA-binding motif; other site 1245469020605 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1245469020606 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469020607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469020608 Walker A/P-loop; other site 1245469020609 ATP binding site [chemical binding]; other site 1245469020610 Q-loop/lid; other site 1245469020611 ABC transporter signature motif; other site 1245469020612 Walker B; other site 1245469020613 D-loop; other site 1245469020614 H-loop/switch region; other site 1245469020615 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1245469020616 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1245469020617 Walker A/P-loop; other site 1245469020618 ATP binding site [chemical binding]; other site 1245469020619 Q-loop/lid; other site 1245469020620 ABC transporter signature motif; other site 1245469020621 Walker B; other site 1245469020622 D-loop; other site 1245469020623 H-loop/switch region; other site 1245469020624 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1245469020625 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1245469020626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020627 dimer interface [polypeptide binding]; other site 1245469020628 conserved gate region; other site 1245469020629 putative PBP binding loops; other site 1245469020630 ABC-ATPase subunit interface; other site 1245469020631 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1245469020632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020633 dimer interface [polypeptide binding]; other site 1245469020634 conserved gate region; other site 1245469020635 putative PBP binding loops; other site 1245469020636 ABC-ATPase subunit interface; other site 1245469020637 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1245469020638 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517 1245469020639 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1245469020640 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1245469020641 Predicted periplasmic protein [Function unknown]; Region: COG3904 1245469020642 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1245469020643 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1245469020644 active site 1245469020645 FMN binding site [chemical binding]; other site 1245469020646 substrate binding site [chemical binding]; other site 1245469020647 homotetramer interface [polypeptide binding]; other site 1245469020648 catalytic residue [active] 1245469020649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 1245469020650 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1245469020651 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1245469020652 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 1245469020653 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1245469020654 metal ion-dependent adhesion site (MIDAS); other site 1245469020655 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 1245469020656 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1245469020657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469020658 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1245469020659 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1245469020660 Citrate synthase; Region: Citrate_synt; pfam00285 1245469020661 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1245469020662 dimer interface [polypeptide binding]; other site 1245469020663 active site 1245469020664 oxalacetate/citrate binding site [chemical binding]; other site 1245469020665 citrylCoA binding site [chemical binding]; other site 1245469020666 coenzyme A binding site [chemical binding]; other site 1245469020667 catalytic triad [active] 1245469020668 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1245469020669 dimer interface [polypeptide binding]; other site 1245469020670 Citrate synthase; Region: Citrate_synt; pfam00285 1245469020671 active site 1245469020672 citrylCoA binding site [chemical binding]; other site 1245469020673 oxalacetate/citrate binding site [chemical binding]; other site 1245469020674 coenzyme A binding site [chemical binding]; other site 1245469020675 catalytic triad [active] 1245469020676 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1245469020677 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1245469020678 HSP70 interaction site [polypeptide binding]; other site 1245469020679 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 1245469020680 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 1245469020681 Domain of unknown function DUF21; Region: DUF21; pfam01595 1245469020682 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1245469020683 Transporter associated domain; Region: CorC_HlyC; smart01091 1245469020684 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1245469020685 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1245469020686 active site 1245469020687 dimer interface [polypeptide binding]; other site 1245469020688 metal binding site [ion binding]; metal-binding site 1245469020689 shikimate kinase; Provisional; Region: PRK13946 1245469020690 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1245469020691 ADP binding site [chemical binding]; other site 1245469020692 magnesium binding site [ion binding]; other site 1245469020693 putative shikimate binding site; other site 1245469020694 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1245469020695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1245469020696 active site 1245469020697 DNA binding site [nucleotide binding] 1245469020698 Int/Topo IB signature motif; other site 1245469020699 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1245469020700 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1245469020701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1245469020702 Predicted transcriptional regulator [Transcription]; Region: COG1959 1245469020703 Transcriptional regulator; Region: Rrf2; pfam02082 1245469020704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469020705 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1245469020706 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1245469020707 Trp docking motif [polypeptide binding]; other site 1245469020708 putative active site [active] 1245469020709 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1245469020710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469020711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469020712 metal binding site [ion binding]; metal-binding site 1245469020713 active site 1245469020714 I-site; other site 1245469020715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469020716 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 1245469020717 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469020718 putative ligand binding site [chemical binding]; other site 1245469020719 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1245469020720 MarR family; Region: MarR_2; pfam12802 1245469020721 AMP-binding domain protein; Validated; Region: PRK07529 1245469020722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469020723 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 1245469020724 acyl-activating enzyme (AAE) consensus motif; other site 1245469020725 putative AMP binding site [chemical binding]; other site 1245469020726 putative active site [active] 1245469020727 putative CoA binding site [chemical binding]; other site 1245469020728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469020729 Coenzyme A binding pocket [chemical binding]; other site 1245469020730 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1245469020731 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1245469020732 active site 1245469020733 catalytic site [active] 1245469020734 metal binding site [ion binding]; metal-binding site 1245469020735 hypothetical protein; Provisional; Region: PRK07538 1245469020736 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1245469020737 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1245469020738 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1245469020739 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1245469020740 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1245469020741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1245469020742 ATP binding site [chemical binding]; other site 1245469020743 putative Mg++ binding site [ion binding]; other site 1245469020744 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1245469020745 SEC-C motif; Region: SEC-C; pfam02810 1245469020746 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1245469020747 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1245469020748 heterotetramer interface [polypeptide binding]; other site 1245469020749 active site pocket [active] 1245469020750 cleavage site 1245469020751 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 1245469020752 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1245469020753 active site 1245469020754 8-oxo-dGMP binding site [chemical binding]; other site 1245469020755 nudix motif; other site 1245469020756 metal binding site [ion binding]; metal-binding site 1245469020757 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1245469020758 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1245469020759 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1245469020760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1245469020761 active site 1245469020762 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1245469020763 GSH binding site [chemical binding]; other site 1245469020764 catalytic residues [active] 1245469020765 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1245469020766 nitrilase; Region: PLN02798 1245469020767 putative active site [active] 1245469020768 catalytic triad [active] 1245469020769 dimer interface [polypeptide binding]; other site 1245469020770 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 1245469020771 Predicted membrane protein [Function unknown]; Region: COG2510 1245469020772 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 1245469020773 GIY-YIG motif/motif A; other site 1245469020774 putative active site [active] 1245469020775 putative metal binding site [ion binding]; other site 1245469020776 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1245469020777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469020778 S-adenosylmethionine binding site [chemical binding]; other site 1245469020779 Bacterial PH domain; Region: DUF304; pfam03703 1245469020780 aspartate kinase; Reviewed; Region: PRK06635 1245469020781 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1245469020782 putative nucleotide binding site [chemical binding]; other site 1245469020783 putative catalytic residues [active] 1245469020784 putative Mg ion binding site [ion binding]; other site 1245469020785 putative aspartate binding site [chemical binding]; other site 1245469020786 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1245469020787 putative allosteric regulatory site; other site 1245469020788 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1245469020789 putative allosteric regulatory residue; other site 1245469020790 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 1245469020791 GAF domain; Region: GAF; pfam01590 1245469020792 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1245469020793 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1245469020794 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1245469020795 peptide chain release factor 2; Provisional; Region: PRK05589 1245469020796 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1245469020797 RF-1 domain; Region: RF-1; pfam00472 1245469020798 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1245469020799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1245469020800 S-adenosylmethionine binding site [chemical binding]; other site 1245469020801 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 1245469020802 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1245469020803 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1245469020804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1245469020805 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 1245469020806 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1245469020807 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 1245469020808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469020809 metal binding site [ion binding]; metal-binding site 1245469020810 active site 1245469020811 I-site; other site 1245469020812 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469020813 aromatic amino acid exporter; Provisional; Region: PRK11689 1245469020814 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 1245469020815 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1245469020816 NAD(P) binding site [chemical binding]; other site 1245469020817 homotetramer interface [polypeptide binding]; other site 1245469020818 homodimer interface [polypeptide binding]; other site 1245469020819 active site 1245469020820 putative acyltransferase; Provisional; Region: PRK05790 1245469020821 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469020822 dimer interface [polypeptide binding]; other site 1245469020823 active site 1245469020824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 1245469020825 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1245469020826 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 1245469020827 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469020828 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469020829 metal binding site [ion binding]; metal-binding site 1245469020830 active site 1245469020831 I-site; other site 1245469020832 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469020833 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1245469020834 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1245469020835 Transglycosylase; Region: Transgly; cl17702 1245469020836 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1245469020837 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1245469020838 substrate binding pocket [chemical binding]; other site 1245469020839 chain length determination region; other site 1245469020840 substrate-Mg2+ binding site; other site 1245469020841 catalytic residues [active] 1245469020842 aspartate-rich region 1; other site 1245469020843 active site lid residues [active] 1245469020844 aspartate-rich region 2; other site 1245469020845 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1245469020846 Caspase domain; Region: Peptidase_C14; pfam00656 1245469020847 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1245469020848 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1245469020849 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1245469020850 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1245469020851 Coenzyme A binding pocket [chemical binding]; other site 1245469020852 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1245469020853 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1245469020854 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1245469020855 EamA-like transporter family; Region: EamA; pfam00892 1245469020856 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1245469020857 EamA-like transporter family; Region: EamA; pfam00892 1245469020858 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1245469020859 metal binding site 2 [ion binding]; metal-binding site 1245469020860 putative DNA binding helix; other site 1245469020861 metal binding site 1 [ion binding]; metal-binding site 1245469020862 dimer interface [polypeptide binding]; other site 1245469020863 structural Zn2+ binding site [ion binding]; other site 1245469020864 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469020865 MarR family; Region: MarR; pfam01047 1245469020866 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1245469020867 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1245469020868 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469020869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469020870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1245469020871 putative substrate translocation pore; other site 1245469020872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1245469020873 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1245469020874 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1245469020875 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1245469020876 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469020877 Ecdysteroid kinase; Region: EcKinase; cl17738 1245469020878 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1245469020879 active site 1245469020880 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1245469020881 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1245469020882 dimer interface [polypeptide binding]; other site 1245469020883 active site 1245469020884 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1245469020885 MutS domain I; Region: MutS_I; pfam01624 1245469020886 MutS domain II; Region: MutS_II; pfam05188 1245469020887 MutS domain III; Region: MutS_III; pfam05192 1245469020888 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1245469020889 Walker A/P-loop; other site 1245469020890 ATP binding site [chemical binding]; other site 1245469020891 Q-loop/lid; other site 1245469020892 ABC transporter signature motif; other site 1245469020893 Walker B; other site 1245469020894 D-loop; other site 1245469020895 H-loop/switch region; other site 1245469020896 TIGR02594 family protein; Region: TIGR02594 1245469020897 OsmC-like protein; Region: OsmC; pfam02566 1245469020898 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1245469020899 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1245469020900 Walker A/P-loop; other site 1245469020901 ATP binding site [chemical binding]; other site 1245469020902 Q-loop/lid; other site 1245469020903 ABC transporter signature motif; other site 1245469020904 Walker B; other site 1245469020905 D-loop; other site 1245469020906 H-loop/switch region; other site 1245469020907 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1245469020908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1245469020909 dimer interface [polypeptide binding]; other site 1245469020910 conserved gate region; other site 1245469020911 putative PBP binding loops; other site 1245469020912 ABC-ATPase subunit interface; other site 1245469020913 NMT1/THI5 like; Region: NMT1; pfam09084 1245469020914 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1245469020915 substrate binding pocket [chemical binding]; other site 1245469020916 membrane-bound complex binding site; other site 1245469020917 hinge residues; other site 1245469020918 PII uridylyl-transferase; Provisional; Region: PRK05092 1245469020919 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1245469020920 metal binding triad; other site 1245469020921 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1245469020922 HD domain; Region: HD; pfam01966 1245469020923 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1245469020924 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1245469020925 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1245469020926 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469020927 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469020928 putative ligand binding site [chemical binding]; other site 1245469020929 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343 1245469020930 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469020931 putative ligand binding site [chemical binding]; other site 1245469020932 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1245469020933 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1245469020934 oligomer interface [polypeptide binding]; other site 1245469020935 active site residues [active] 1245469020936 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1245469020937 putative hydrophobic ligand binding site [chemical binding]; other site 1245469020938 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469020939 dimerization interface [polypeptide binding]; other site 1245469020940 putative DNA binding site [nucleotide binding]; other site 1245469020941 putative Zn2+ binding site [ion binding]; other site 1245469020942 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1245469020943 Transglycosylase; Region: Transgly; pfam00912 1245469020944 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1245469020945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1245469020946 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1245469020947 PAS domain; Region: PAS_9; pfam13426 1245469020948 putative active site [active] 1245469020949 heme pocket [chemical binding]; other site 1245469020950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1245469020951 GAF domain; Region: GAF; pfam01590 1245469020952 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469020953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469020954 metal binding site [ion binding]; metal-binding site 1245469020955 active site 1245469020956 I-site; other site 1245469020957 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469020958 Protein of unknown function DUF45; Region: DUF45; pfam01863 1245469020959 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 1245469020960 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1245469020961 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1245469020962 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1245469020963 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1245469020964 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1245469020965 Walker A/P-loop; other site 1245469020966 ATP binding site [chemical binding]; other site 1245469020967 Q-loop/lid; other site 1245469020968 ABC transporter signature motif; other site 1245469020969 Walker B; other site 1245469020970 D-loop; other site 1245469020971 H-loop/switch region; other site 1245469020972 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1245469020973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469020974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469020975 dimer interface [polypeptide binding]; other site 1245469020976 phosphorylation site [posttranslational modification] 1245469020977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469020978 ATP binding site [chemical binding]; other site 1245469020979 Mg2+ binding site [ion binding]; other site 1245469020980 G-X-G motif; other site 1245469020981 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1245469020982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469020983 active site 1245469020984 phosphorylation site [posttranslational modification] 1245469020985 intermolecular recognition site; other site 1245469020986 dimerization interface [polypeptide binding]; other site 1245469020987 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1245469020988 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1245469020989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1245469020990 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1245469020991 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1245469020992 active site 1245469020993 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1245469020994 Protein of unknown function (DUF1052); Region: DUF1052; pfam06319 1245469020995 trehalose synthase; Region: treS_nterm; TIGR02456 1245469020996 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1245469020997 active site 1245469020998 catalytic site [active] 1245469020999 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 1245469021000 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1245469021001 active site 1245469021002 catalytic site [active] 1245469021003 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1245469021004 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1245469021005 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1245469021006 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1245469021007 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1245469021008 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1245469021009 Response regulator receiver domain; Region: Response_reg; pfam00072 1245469021010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469021011 active site 1245469021012 phosphorylation site [posttranslational modification] 1245469021013 intermolecular recognition site; other site 1245469021014 dimerization interface [polypeptide binding]; other site 1245469021015 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 1245469021016 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 1245469021017 DNA binding residues [nucleotide binding] 1245469021018 dimer interface [polypeptide binding]; other site 1245469021019 putative metal binding site [ion binding]; other site 1245469021020 hypothetical protein; Provisional; Region: PRK02237 1245469021021 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1245469021022 Cytochrome P450; Region: p450; cl12078 1245469021023 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469021024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1245469021025 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1245469021026 NAD(P) binding site [chemical binding]; other site 1245469021027 active site 1245469021028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1245469021029 HWE histidine kinase; Region: HWE_HK; smart00911 1245469021030 PAS fold; Region: PAS_4; pfam08448 1245469021031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469021032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469021033 metal binding site [ion binding]; metal-binding site 1245469021034 active site 1245469021035 I-site; other site 1245469021036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469021037 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1245469021038 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 1245469021039 putative ligand binding site [chemical binding]; other site 1245469021040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1245469021041 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1245469021042 Walker A/P-loop; other site 1245469021043 ATP binding site [chemical binding]; other site 1245469021044 Q-loop/lid; other site 1245469021045 ABC transporter signature motif; other site 1245469021046 Walker B; other site 1245469021047 D-loop; other site 1245469021048 H-loop/switch region; other site 1245469021049 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1245469021050 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1245469021051 Walker A/P-loop; other site 1245469021052 ATP binding site [chemical binding]; other site 1245469021053 Q-loop/lid; other site 1245469021054 ABC transporter signature motif; other site 1245469021055 Walker B; other site 1245469021056 D-loop; other site 1245469021057 H-loop/switch region; other site 1245469021058 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1245469021059 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1245469021060 TM-ABC transporter signature motif; other site 1245469021061 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1245469021062 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1245469021063 TM-ABC transporter signature motif; other site 1245469021064 PAS fold; Region: PAS_7; pfam12860 1245469021065 PAS domain; Region: PAS; smart00091 1245469021066 PAS fold; Region: PAS_4; pfam08448 1245469021067 putative active site [active] 1245469021068 heme pocket [chemical binding]; other site 1245469021069 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1245469021070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1245469021071 metal binding site [ion binding]; metal-binding site 1245469021072 active site 1245469021073 I-site; other site 1245469021074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1245469021075 hypothetical protein; Provisional; Region: PRK11770 1245469021076 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1245469021077 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1245469021078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469021079 non-specific DNA binding site [nucleotide binding]; other site 1245469021080 salt bridge; other site 1245469021081 sequence-specific DNA binding site [nucleotide binding]; other site 1245469021082 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1245469021083 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1245469021084 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 1245469021085 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 1245469021086 Predicted metal binding domain; Region: Metal_CEHH; pfam14455 1245469021087 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1245469021088 E1 N-terminal domain; Region: E1-N; pfam14463 1245469021089 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1245469021090 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 1245469021091 RNase_H superfamily; Region: RNase_H_2; pfam13482 1245469021092 AAA domain; Region: AAA_30; pfam13604 1245469021093 AAA domain; Region: AAA_11; pfam13086 1245469021094 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1245469021095 AAA domain; Region: AAA_12; pfam13087 1245469021096 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1245469021097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1245469021098 ATP binding site [chemical binding]; other site 1245469021099 putative Mg++ binding site [ion binding]; other site 1245469021100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1245469021101 nucleotide binding region [chemical binding]; other site 1245469021102 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1245469021103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1245469021104 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 1245469021105 Conjugal transfer protein TraD; Region: TraD; pfam06412 1245469021106 Conjugal transfer protein TraD; Region: TraD; pfam06412 1245469021107 conjugal transfer relaxase TraA; Provisional; Region: PRK13889 1245469021108 MobA/MobL family; Region: MobA_MobL; pfam03389 1245469021109 AAA domain; Region: AAA_30; pfam13604 1245469021110 Family description; Region: UvrD_C_2; pfam13538 1245469021111 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 1245469021112 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1245469021113 active site 1245469021114 NTP binding site [chemical binding]; other site 1245469021115 metal binding triad [ion binding]; metal-binding site 1245469021116 antibiotic binding site [chemical binding]; other site 1245469021117 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1245469021118 active site 1245469021119 catalytic site [active] 1245469021120 substrate binding site [chemical binding]; other site 1245469021121 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1245469021122 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1245469021123 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1245469021124 sequence-specific DNA binding site [nucleotide binding]; other site 1245469021125 salt bridge; other site 1245469021126 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1245469021127 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1245469021128 ligand binding site [chemical binding]; other site 1245469021129 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1245469021130 cyclase homology domain; Region: CHD; cd07302 1245469021131 nucleotidyl binding site; other site 1245469021132 metal binding site [ion binding]; metal-binding site 1245469021133 dimer interface [polypeptide binding]; other site 1245469021134 cyclase homology domain; Region: CHD; cd07302 1245469021135 dimer interface [polypeptide binding]; other site 1245469021136 nucleotidyl binding site; other site 1245469021137 metal binding site [ion binding]; metal-binding site 1245469021138 cyclase homology domain; Region: CHD; cd07302 1245469021139 nucleotidyl binding site; other site 1245469021140 metal binding site [ion binding]; metal-binding site 1245469021141 dimer interface [polypeptide binding]; other site 1245469021142 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 1245469021143 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1245469021144 active site 1245469021145 DNA binding site [nucleotide binding] 1245469021146 Int/Topo IB signature motif; other site 1245469021147 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1245469021148 active site 1245469021149 catalytic residues [active] 1245469021150 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1245469021151 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1245469021152 active site 1245469021153 Predicted integral membrane protein [Function unknown]; Region: COG5616 1245469021154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469021155 TPR motif; other site 1245469021156 binding surface 1245469021157 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1245469021158 peptidase domain interface [polypeptide binding]; other site 1245469021159 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1245469021160 active site 1245469021161 catalytic triad [active] 1245469021162 calcium binding site [ion binding]; other site 1245469021163 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1245469021164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469021165 DNA-binding site [nucleotide binding]; DNA binding site 1245469021166 FCD domain; Region: FCD; pfam07729 1245469021167 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1245469021168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1245469021169 putative substrate translocation pore; other site 1245469021170 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1245469021171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469021172 active site 1245469021173 phosphorylation site [posttranslational modification] 1245469021174 intermolecular recognition site; other site 1245469021175 dimerization interface [polypeptide binding]; other site 1245469021176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1245469021177 Walker A motif; other site 1245469021178 ATP binding site [chemical binding]; other site 1245469021179 Walker B motif; other site 1245469021180 arginine finger; other site 1245469021181 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1245469021182 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1245469021183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469021184 dimer interface [polypeptide binding]; other site 1245469021185 phosphorylation site [posttranslational modification] 1245469021186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469021187 ATP binding site [chemical binding]; other site 1245469021188 Mg2+ binding site [ion binding]; other site 1245469021189 G-X-G motif; other site 1245469021190 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1245469021191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1245469021192 DNA-binding site [nucleotide binding]; DNA binding site 1245469021193 FCD domain; Region: FCD; pfam07729 1245469021194 Predicted ATPase [General function prediction only]; Region: COG3899 1245469021195 AAA ATPase domain; Region: AAA_16; pfam13191 1245469021196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1245469021197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469021198 DNA binding residues [nucleotide binding] 1245469021199 dimerization interface [polypeptide binding]; other site 1245469021200 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1245469021201 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 1245469021202 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1245469021203 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1245469021204 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 1245469021205 type III secretion system protein YscR; Provisional; Region: PRK12797 1245469021206 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1245469021207 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1245469021208 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 1245469021209 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1245469021210 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1245469021211 Walker A motif; other site 1245469021212 ATP binding site [chemical binding]; other site 1245469021213 Walker B motif; other site 1245469021214 Nodulation protein NolV; Region: NolV; pfam06635 1245469021215 Flagellar assembly protein FliH; Region: FliH; pfam02108 1245469021216 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1245469021217 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 1245469021218 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 1245469021219 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1245469021220 FHIPEP family; Region: FHIPEP; pfam00771 1245469021221 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1245469021222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469021223 TPR motif; other site 1245469021224 binding surface 1245469021225 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1245469021226 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1245469021227 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1245469021228 Type IV pili component [Cell motility and secretion]; Region: COG5461 1245469021229 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1245469021230 B12 binding site [chemical binding]; other site 1245469021231 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1245469021232 Deoxyhypusine synthase; Region: DS; cl00826 1245469021233 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 1245469021234 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1245469021235 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469021236 catalytic residue [active] 1245469021237 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1245469021238 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1245469021239 Cupin-like domain; Region: Cupin_8; pfam13621 1245469021240 Cupin-like domain; Region: Cupin_8; pfam13621 1245469021241 Phosphotransferase enzyme family; Region: APH; pfam01636 1245469021242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1245469021243 active site 1245469021244 ATP binding site [chemical binding]; other site 1245469021245 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1245469021246 B12 binding site [chemical binding]; other site 1245469021247 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1245469021248 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1245469021249 putative di-iron ligands [ion binding]; other site 1245469021250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1245469021251 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1245469021252 acyl-activating enzyme (AAE) consensus motif; other site 1245469021253 active site 1245469021254 AMP binding site [chemical binding]; other site 1245469021255 CoA binding site [chemical binding]; other site 1245469021256 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1245469021257 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1245469021258 active site 1245469021259 metal binding site [ion binding]; metal-binding site 1245469021260 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1245469021261 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 1245469021262 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1245469021263 active site 1245469021264 formamidase; Provisional; Region: amiF; PRK13287 1245469021265 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 1245469021266 multimer interface [polypeptide binding]; other site 1245469021267 active site 1245469021268 catalytic triad [active] 1245469021269 dimer interface [polypeptide binding]; other site 1245469021270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1245469021271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1245469021272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 1245469021273 SnoaL-like domain; Region: SnoaL_2; pfam12680 1245469021274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1245469021275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1245469021276 dimer interface [polypeptide binding]; other site 1245469021277 phosphorylation site [posttranslational modification] 1245469021278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1245469021279 ATP binding site [chemical binding]; other site 1245469021280 Mg2+ binding site [ion binding]; other site 1245469021281 G-X-G motif; other site 1245469021282 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1245469021283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1245469021284 active site 1245469021285 phosphorylation site [posttranslational modification] 1245469021286 intermolecular recognition site; other site 1245469021287 dimerization interface [polypeptide binding]; other site 1245469021288 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 1245469021289 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1245469021290 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1245469021291 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1245469021292 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1245469021293 Walker A/P-loop; other site 1245469021294 ATP binding site [chemical binding]; other site 1245469021295 Q-loop/lid; other site 1245469021296 ABC transporter signature motif; other site 1245469021297 Walker B; other site 1245469021298 D-loop; other site 1245469021299 H-loop/switch region; other site 1245469021300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1245469021301 Walker A/P-loop; other site 1245469021302 ATP binding site [chemical binding]; other site 1245469021303 Q-loop/lid; other site 1245469021304 ABC transporter signature motif; other site 1245469021305 Walker B; other site 1245469021306 D-loop; other site 1245469021307 H-loop/switch region; other site 1245469021308 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1245469021309 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1245469021310 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1245469021311 HlyD family secretion protein; Region: HlyD_3; pfam13437 1245469021312 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 1245469021313 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1245469021314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1245469021315 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1245469021316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1245469021317 DNA binding residues [nucleotide binding] 1245469021318 dimerization interface [polypeptide binding]; other site 1245469021319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469021320 binding surface 1245469021321 TPR motif; other site 1245469021322 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1245469021323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469021324 binding surface 1245469021325 TPR motif; other site 1245469021326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1245469021327 binding surface 1245469021328 TPR motif; other site 1245469021329 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1245469021330 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14839 1245469021331 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1245469021332 catalytic residue [active] 1245469021333 putative FPP diphosphate binding site; other site 1245469021334 putative FPP binding hydrophobic cleft; other site 1245469021335 dimer interface [polypeptide binding]; other site 1245469021336 putative IPP diphosphate binding site; other site 1245469021337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1245469021338 putative DNA binding site [nucleotide binding]; other site 1245469021339 dimerization interface [polypeptide binding]; other site 1245469021340 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1245469021341 putative Zn2+ binding site [ion binding]; other site 1245469021342 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1245469021343 Protein of unknown function (DUF3551); Region: DUF3551; pfam12071 1245469021344 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1245469021345 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1245469021346 dimer interface [polypeptide binding]; other site 1245469021347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1245469021348 metal binding site [ion binding]; metal-binding site 1245469021349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 1245469021350 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1245469021351 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1245469021352 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1245469021353 acyl-activating enzyme (AAE) consensus motif; other site 1245469021354 putative AMP binding site [chemical binding]; other site 1245469021355 putative active site [active] 1245469021356 putative CoA binding site [chemical binding]; other site 1245469021357 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1245469021358 Cytochrome P450; Region: p450; cl12078 1245469021359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1245469021360 active site 1245469021361 phosphorylation site [posttranslational modification] 1245469021362 dimerization interface [polypeptide binding]; other site 1245469021363 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1245469021364 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1245469021365 Zn2+ binding site [ion binding]; other site 1245469021366 Mg2+ binding site [ion binding]; other site 1245469021367 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1245469021368 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469021369 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1245469021370 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469021371 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1245469021372 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1245469021373 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1245469021374 catalytic loop [active] 1245469021375 iron binding site [ion binding]; other site 1245469021376 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1245469021377 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1245469021378 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1245469021379 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1245469021380 SLBB domain; Region: SLBB; pfam10531 1245469021381 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1245469021382 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239