-- dump date 20140618_193530 -- class Genbank::misc_feature -- table misc_feature_note -- id note 349741000001 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 349741000002 dimer interface [polypeptide binding]; other site 349741000003 ADP-ribose binding site [chemical binding]; other site 349741000004 active site 349741000005 nudix motif; other site 349741000006 metal binding site [ion binding]; metal-binding site 349741000007 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 349741000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741000009 Walker A motif; other site 349741000010 ATP binding site [chemical binding]; other site 349741000011 Walker B motif; other site 349741000012 arginine finger; other site 349741000013 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 349741000014 DnaA box-binding interface [nucleotide binding]; other site 349741000015 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 349741000016 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 349741000017 Walker A/P-loop; other site 349741000018 ATP binding site [chemical binding]; other site 349741000019 Q-loop/lid; other site 349741000020 ABC transporter signature motif; other site 349741000021 Walker B; other site 349741000022 D-loop; other site 349741000023 H-loop/switch region; other site 349741000024 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 349741000025 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 349741000026 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 349741000027 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 349741000028 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 349741000029 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 349741000030 Uncharacterized conserved protein [Function unknown]; Region: COG0327 349741000031 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 349741000032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349741000033 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 349741000034 RNA binding surface [nucleotide binding]; other site 349741000035 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 349741000036 active site 349741000037 Chorismate mutase type II; Region: CM_2; smart00830 349741000038 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 349741000039 Prephenate dehydratase; Region: PDT; pfam00800 349741000040 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 349741000041 putative L-Phe binding site [chemical binding]; other site 349741000042 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 349741000043 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 349741000044 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 349741000045 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 349741000046 nucleotide binding pocket [chemical binding]; other site 349741000047 K-X-D-G motif; other site 349741000048 catalytic site [active] 349741000049 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 349741000050 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 349741000051 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 349741000052 Dimer interface [polypeptide binding]; other site 349741000053 BRCT sequence motif; other site 349741000054 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 349741000055 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 349741000056 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 349741000057 ATP binding site [chemical binding]; other site 349741000058 Mg++ binding site [ion binding]; other site 349741000059 motif III; other site 349741000060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741000061 nucleotide binding region [chemical binding]; other site 349741000062 ATP-binding site [chemical binding]; other site 349741000063 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349741000064 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 349741000065 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 349741000066 metal binding site [ion binding]; metal-binding site 349741000067 putative MFS family transporter protein; Provisional; Region: PRK03633 349741000068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741000069 putative substrate translocation pore; other site 349741000070 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 349741000071 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 349741000072 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 349741000073 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 349741000074 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741000075 active site 349741000076 catalytic triad [active] 349741000077 oxyanion hole [active] 349741000078 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 349741000079 Predicted membrane protein [Function unknown]; Region: COG1971 349741000080 Domain of unknown function DUF; Region: DUF204; pfam02659 349741000081 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 349741000082 recombination factor protein RarA; Reviewed; Region: PRK13342 349741000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741000084 Walker A motif; other site 349741000085 ATP binding site [chemical binding]; other site 349741000086 Walker B motif; other site 349741000087 arginine finger; other site 349741000088 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 349741000089 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 349741000090 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 349741000091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741000092 NAD(P) binding site [chemical binding]; other site 349741000093 active site 349741000094 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 349741000095 Phosphotransferase enzyme family; Region: APH; pfam01636 349741000096 catalytic site [active] 349741000097 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 349741000098 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 349741000099 active site 349741000100 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 349741000101 Peptidase family M50; Region: Peptidase_M50; pfam02163 349741000102 active site 349741000103 putative substrate binding region [chemical binding]; other site 349741000104 prolyl-tRNA synthetase; Provisional; Region: PRK08661 349741000105 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 349741000106 dimer interface [polypeptide binding]; other site 349741000107 motif 1; other site 349741000108 active site 349741000109 motif 2; other site 349741000110 motif 3; other site 349741000111 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 349741000112 anticodon binding site; other site 349741000113 zinc-binding site [ion binding]; other site 349741000114 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741000115 RHS Repeat; Region: RHS_repeat; pfam05593 349741000116 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741000117 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741000118 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 349741000119 glutaminase; Reviewed; Region: PRK12356 349741000120 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 349741000121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741000122 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349741000123 Coenzyme A binding pocket [chemical binding]; other site 349741000124 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 349741000125 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 349741000126 peptide chain release factor 1; Validated; Region: prfA; PRK00591 349741000127 This domain is found in peptide chain release factors; Region: PCRF; smart00937 349741000128 RF-1 domain; Region: RF-1; pfam00472 349741000129 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 349741000130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741000131 S-adenosylmethionine binding site [chemical binding]; other site 349741000132 primosome assembly protein PriA; Validated; Region: PRK05580 349741000133 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741000134 ATP binding site [chemical binding]; other site 349741000135 putative Mg++ binding site [ion binding]; other site 349741000136 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741000137 ATP-binding site [chemical binding]; other site 349741000138 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 349741000139 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 349741000140 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 349741000141 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 349741000142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741000143 S-adenosylmethionine binding site [chemical binding]; other site 349741000144 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 349741000145 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 349741000146 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 349741000147 DHH family; Region: DHH; pfam01368 349741000148 DHHA1 domain; Region: DHHA1; pfam02272 349741000149 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 349741000150 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741000151 sugar binding site [chemical binding]; other site 349741000152 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 349741000153 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 349741000154 intersubunit interface [polypeptide binding]; other site 349741000155 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 349741000156 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 349741000157 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 349741000158 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 349741000159 ABC-ATPase subunit interface; other site 349741000160 dimer interface [polypeptide binding]; other site 349741000161 putative PBP binding regions; other site 349741000162 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 349741000163 UvrB/uvrC motif; Region: UVR; pfam02151 349741000164 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 349741000165 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 349741000166 ADP binding site [chemical binding]; other site 349741000167 phosphagen binding site; other site 349741000168 substrate specificity loop; other site 349741000169 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 349741000170 Clp amino terminal domain; Region: Clp_N; pfam02861 349741000171 Clp amino terminal domain; Region: Clp_N; pfam02861 349741000172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741000173 Walker A motif; other site 349741000174 ATP binding site [chemical binding]; other site 349741000175 Walker B motif; other site 349741000176 arginine finger; other site 349741000177 UvrB/uvrC motif; Region: UVR; pfam02151 349741000178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741000179 Walker A motif; other site 349741000180 ATP binding site [chemical binding]; other site 349741000181 Walker B motif; other site 349741000182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 349741000183 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 349741000184 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 349741000185 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 349741000186 Restriction endonuclease EcoRI; Region: EcoRI; pfam02963 349741000187 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 349741000188 active site residue [active] 349741000189 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 349741000190 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 349741000191 2-isopropylmalate synthase; Validated; Region: PRK00915 349741000192 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 349741000193 active site 349741000194 catalytic residues [active] 349741000195 metal binding site [ion binding]; metal-binding site 349741000196 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 349741000197 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 349741000198 Yqey-like protein; Region: YqeY; pfam09424 349741000199 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 349741000200 substrate binding site; other site 349741000201 dimer interface; other site 349741000202 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 349741000203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741000204 NAD(P) binding site [chemical binding]; other site 349741000205 active site 349741000206 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 349741000207 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 349741000208 active site 349741000209 HIGH motif; other site 349741000210 dimer interface [polypeptide binding]; other site 349741000211 KMSKS motif; other site 349741000212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 349741000213 Ligand Binding Site [chemical binding]; other site 349741000214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349741000215 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 349741000216 putative active site [active] 349741000217 metal binding site [ion binding]; metal-binding site 349741000218 homodimer binding site [polypeptide binding]; other site 349741000219 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 349741000220 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 349741000221 putative ATP binding site [chemical binding]; other site 349741000222 putative substrate interface [chemical binding]; other site 349741000223 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 349741000224 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 349741000225 putative substrate binding site [chemical binding]; other site 349741000226 putative ATP binding site [chemical binding]; other site 349741000227 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 349741000228 putative active site [active] 349741000229 nucleotide binding site [chemical binding]; other site 349741000230 nudix motif; other site 349741000231 putative metal binding site [ion binding]; other site 349741000232 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 349741000233 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 349741000234 substrate-cofactor binding pocket; other site 349741000235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741000236 catalytic residue [active] 349741000237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 349741000238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349741000239 active site 349741000240 ATP binding site [chemical binding]; other site 349741000241 substrate binding site [chemical binding]; other site 349741000242 activation loop (A-loop); other site 349741000243 PEGA domain; Region: PEGA; pfam08308 349741000244 PEGA domain; Region: PEGA; pfam08308 349741000245 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 349741000246 Uncharacterized conserved protein [Function unknown]; Region: COG1262 349741000247 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 349741000248 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349741000249 P-loop; other site 349741000250 Magnesium ion binding site [ion binding]; other site 349741000251 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 349741000252 Magnesium ion binding site [ion binding]; other site 349741000253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 349741000254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349741000255 active site 349741000256 ATP binding site [chemical binding]; other site 349741000257 substrate binding site [chemical binding]; other site 349741000258 activation loop (A-loop); other site 349741000259 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741000260 PA14 domain; Region: PA14; cl08459 349741000261 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 349741000262 thiS-thiF/thiG interaction site; other site 349741000263 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 349741000264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741000265 ATP binding site [chemical binding]; other site 349741000266 Mg2+ binding site [ion binding]; other site 349741000267 G-X-G motif; other site 349741000268 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 349741000269 ATP binding site [chemical binding]; other site 349741000270 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 349741000271 O-Antigen ligase; Region: Wzy_C; pfam04932 349741000272 Uncharacterized conserved protein [Function unknown]; Region: COG3189 349741000273 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 349741000274 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 349741000275 domain interfaces; other site 349741000276 active site 349741000277 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 349741000278 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 349741000279 tRNA; other site 349741000280 putative tRNA binding site [nucleotide binding]; other site 349741000281 putative NADP binding site [chemical binding]; other site 349741000282 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 349741000283 putative GTP cyclohydrolase; Provisional; Region: PRK13674 349741000284 Ribosomal protein S18; Region: Ribosomal_S18; pfam01084 349741000285 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 349741000286 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 349741000287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 349741000288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349741000289 nucleotide binding site [chemical binding]; other site 349741000290 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 349741000291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741000292 S-adenosylmethionine binding site [chemical binding]; other site 349741000293 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 349741000294 active site 349741000295 metal binding site [ion binding]; metal-binding site 349741000296 homotetramer interface [polypeptide binding]; other site 349741000297 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 349741000298 active site 349741000299 8-oxo-dGMP binding site [chemical binding]; other site 349741000300 nudix motif; other site 349741000301 metal binding site [ion binding]; metal-binding site 349741000302 macrolide transporter subunit MacA; Provisional; Region: PRK11578 349741000303 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741000304 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349741000305 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349741000306 Walker A/P-loop; other site 349741000307 ATP binding site [chemical binding]; other site 349741000308 Q-loop/lid; other site 349741000309 ABC transporter signature motif; other site 349741000310 Walker B; other site 349741000311 D-loop; other site 349741000312 H-loop/switch region; other site 349741000313 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 349741000314 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 349741000315 FtsX-like permease family; Region: FtsX; pfam02687 349741000316 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 349741000317 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 349741000318 Beta-lactamase; Region: Beta-lactamase; pfam00144 349741000319 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 349741000320 Protein export membrane protein; Region: SecD_SecF; cl14618 349741000321 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 349741000322 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 349741000323 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741000324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349741000325 MarR family; Region: MarR_2; pfam12802 349741000326 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 349741000327 homodimer interaction site [polypeptide binding]; other site 349741000328 cofactor binding site; other site 349741000329 Protein of unknown function (DUF3788); Region: DUF3788; pfam12663 349741000330 dihydroorotase; Validated; Region: pyrC; PRK09357 349741000331 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 349741000332 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 349741000333 active site 349741000334 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 349741000335 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 349741000336 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 349741000337 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 349741000338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349741000339 active site 349741000340 AIR carboxylase; Region: AIRC; pfam00731 349741000341 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 349741000342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349741000343 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 349741000344 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 349741000345 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 349741000346 Aspartyl protease; Region: Asp_protease_2; pfam13650 349741000347 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741000348 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 349741000349 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 349741000350 Domain of unknown function DUF20; Region: UPF0118; pfam01594 349741000351 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741000352 Sulfatase; Region: Sulfatase; pfam00884 349741000353 Domain of unknown function (DUF303); Region: DUF303; pfam03629 349741000354 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741000355 active site 349741000356 catalytic triad [active] 349741000357 oxyanion hole [active] 349741000358 SecA DEAD-like domain; Region: SecA_DEAD; pfam07517 349741000359 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 349741000360 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 349741000361 CAP-like domain; other site 349741000362 active site 349741000363 primary dimer interface [polypeptide binding]; other site 349741000364 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 349741000365 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 349741000366 ParB-like nuclease domain; Region: ParBc; pfam02195 349741000367 KorB domain; Region: KorB; pfam08535 349741000368 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 349741000369 Peptidase family M28; Region: Peptidase_M28; pfam04389 349741000370 metal binding site [ion binding]; metal-binding site 349741000371 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 349741000372 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 349741000373 metal ion-dependent adhesion site (MIDAS); other site 349741000374 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 349741000375 MG2 domain; Region: A2M_N; pfam01835 349741000376 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 349741000377 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 349741000378 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 349741000379 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 349741000380 active site 349741000381 HIGH motif; other site 349741000382 dimer interface [polypeptide binding]; other site 349741000383 KMSKS motif; other site 349741000384 Protein of unknown function, DUF486; Region: DUF486; cl01236 349741000385 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 349741000386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741000387 dimer interface [polypeptide binding]; other site 349741000388 conserved gate region; other site 349741000389 putative PBP binding loops; other site 349741000390 ABC-ATPase subunit interface; other site 349741000391 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 349741000392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741000393 dimer interface [polypeptide binding]; other site 349741000394 conserved gate region; other site 349741000395 putative PBP binding loops; other site 349741000396 ABC-ATPase subunit interface; other site 349741000397 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 349741000398 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 349741000399 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 349741000400 peptide binding site [polypeptide binding]; other site 349741000401 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 349741000402 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 349741000403 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 349741000404 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 349741000405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741000406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349741000407 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 349741000408 active site 349741000409 metal binding site [ion binding]; metal-binding site 349741000410 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 349741000411 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 349741000412 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 349741000413 nucleotide binding site [chemical binding]; other site 349741000414 SulA interaction site; other site 349741000415 cell division protein FtsA; Region: ftsA; TIGR01174 349741000416 Cell division protein FtsA; Region: FtsA; smart00842 349741000417 Cell division protein FtsA; Region: FtsA; pfam14450 349741000418 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 349741000419 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 349741000420 active site 349741000421 substrate binding site [chemical binding]; other site 349741000422 metal binding site [ion binding]; metal-binding site 349741000423 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 349741000424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349741000425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741000426 Walker A/P-loop; other site 349741000427 ATP binding site [chemical binding]; other site 349741000428 Q-loop/lid; other site 349741000429 ABC transporter signature motif; other site 349741000430 Walker B; other site 349741000431 D-loop; other site 349741000432 H-loop/switch region; other site 349741000433 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 349741000434 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 349741000435 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 349741000436 Walker A/P-loop; other site 349741000437 ATP binding site [chemical binding]; other site 349741000438 Q-loop/lid; other site 349741000439 ABC transporter signature motif; other site 349741000440 Walker B; other site 349741000441 D-loop; other site 349741000442 H-loop/switch region; other site 349741000443 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 349741000444 NAD synthetase; Provisional; Region: PRK13981 349741000445 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 349741000446 Permease; Region: Permease; pfam02405 349741000447 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 349741000448 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 349741000449 Walker A/P-loop; other site 349741000450 ATP binding site [chemical binding]; other site 349741000451 Q-loop/lid; other site 349741000452 ABC transporter signature motif; other site 349741000453 Walker B; other site 349741000454 D-loop; other site 349741000455 H-loop/switch region; other site 349741000456 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 349741000457 mce related protein; Region: MCE; pfam02470 349741000458 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 349741000459 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 349741000460 Walker A motif; other site 349741000461 ATP binding site [chemical binding]; other site 349741000462 Walker B motif; other site 349741000463 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 349741000464 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 349741000465 Walker A motif; other site 349741000466 ATP binding site [chemical binding]; other site 349741000467 Walker B motif; other site 349741000468 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 349741000469 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 349741000470 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 349741000471 Ligand binding site; other site 349741000472 oligomer interface; other site 349741000473 CTP synthetase; Validated; Region: pyrG; PRK05380 349741000474 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 349741000475 Catalytic site [active] 349741000476 active site 349741000477 UTP binding site [chemical binding]; other site 349741000478 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 349741000479 active site 349741000480 putative oxyanion hole; other site 349741000481 catalytic triad [active] 349741000482 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 349741000483 Na binding site [ion binding]; other site 349741000484 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 349741000485 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741000486 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349741000487 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741000488 Transglycosylase; Region: Transgly; pfam00912 349741000489 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 349741000490 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 349741000491 RmuC family; Region: RmuC; pfam02646 349741000492 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 349741000493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741000494 motif II; other site 349741000495 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 349741000496 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 349741000497 active site 349741000498 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 349741000499 RDD family; Region: RDD; pfam06271 349741000500 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 349741000501 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 349741000502 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 349741000503 FtsX-like permease family; Region: FtsX; pfam02687 349741000504 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 349741000505 Protein of unknown function (DUF456); Region: DUF456; pfam04306 349741000506 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 349741000507 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 349741000508 Peptidase family M28; Region: Peptidase_M28; pfam04389 349741000509 metal binding site [ion binding]; metal-binding site 349741000510 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 349741000511 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 349741000512 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 349741000513 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 349741000514 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741000515 active site 349741000516 HIGH motif; other site 349741000517 nucleotide binding site [chemical binding]; other site 349741000518 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 349741000519 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741000520 active site 349741000521 KMSKS motif; other site 349741000522 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 349741000523 tRNA binding surface [nucleotide binding]; other site 349741000524 anticodon binding site; other site 349741000525 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 349741000526 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 349741000527 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 349741000528 active site residue [active] 349741000529 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 349741000530 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 349741000531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741000532 catalytic residue [active] 349741000533 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 349741000534 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 349741000535 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 349741000536 ATP binding site [chemical binding]; other site 349741000537 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741000538 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 349741000539 TIGR03790 family protein; Region: TIGR03790 349741000540 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 349741000541 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 349741000542 dimer interface [polypeptide binding]; other site 349741000543 substrate binding site [chemical binding]; other site 349741000544 metal binding site [ion binding]; metal-binding site 349741000545 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 349741000546 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 349741000547 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 349741000548 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 349741000549 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 349741000550 carboxyltransferase (CT) interaction site; other site 349741000551 biotinylation site [posttranslational modification]; other site 349741000552 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 349741000553 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 349741000554 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 349741000555 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 349741000556 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 349741000557 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 349741000558 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 349741000559 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 349741000560 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 349741000561 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 349741000562 substrate binding site; other site 349741000563 tetramer interface; other site 349741000564 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 349741000565 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 349741000566 NAD binding site [chemical binding]; other site 349741000567 substrate binding site [chemical binding]; other site 349741000568 homodimer interface [polypeptide binding]; other site 349741000569 active site 349741000570 6-phosphofructokinase; Provisional; Region: PRK03202 349741000571 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 349741000572 active site 349741000573 ADP/pyrophosphate binding site [chemical binding]; other site 349741000574 dimerization interface [polypeptide binding]; other site 349741000575 allosteric effector site; other site 349741000576 fructose-1,6-bisphosphate binding site; other site 349741000577 SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029 349741000578 active site 349741000579 substrate specificity residue; other site 349741000580 DNA binding site [nucleotide binding] 349741000581 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 349741000582 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 349741000583 GatB domain; Region: GatB_Yqey; smart00845 349741000584 pyruvate dehydrogenase; Provisional; Region: PRK09124 349741000585 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 349741000586 PYR/PP interface [polypeptide binding]; other site 349741000587 dimer interface [polypeptide binding]; other site 349741000588 tetramer interface [polypeptide binding]; other site 349741000589 TPP binding site [chemical binding]; other site 349741000590 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 349741000591 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 349741000592 TPP-binding site [chemical binding]; other site 349741000593 PEP-CTERM motif; Region: VPEP; pfam07589 349741000594 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 349741000595 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 349741000596 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741000597 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 349741000598 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349741000599 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 349741000600 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 349741000601 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 349741000602 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741000603 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 349741000604 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 349741000605 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 349741000606 transmembrane helices; other site 349741000607 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 349741000608 substrate binding site [chemical binding]; other site 349741000609 dimer interface [polypeptide binding]; other site 349741000610 ATP binding site [chemical binding]; other site 349741000611 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741000612 Sel1-like repeats; Region: SEL1; smart00671 349741000613 Sel1-like repeats; Region: SEL1; smart00671 349741000614 Sel1-like repeats; Region: SEL1; smart00671 349741000615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741000616 S-adenosylmethionine binding site [chemical binding]; other site 349741000617 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 349741000618 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 349741000619 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 349741000620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741000621 NAD(P) binding site [chemical binding]; other site 349741000622 active site 349741000623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 349741000624 active site 349741000625 catalytic residues [active] 349741000626 metal binding site [ion binding]; metal-binding site 349741000627 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 349741000628 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 349741000629 NAD(P) binding site [chemical binding]; other site 349741000630 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 349741000631 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741000632 Ion transport protein; Region: Ion_trans; pfam00520 349741000633 Ion channel; Region: Ion_trans_2; pfam07885 349741000634 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 349741000635 ArsC family; Region: ArsC; pfam03960 349741000636 putative ArsC-like catalytic residues; other site 349741000637 putative TRX-like catalytic residues [active] 349741000638 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 349741000639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 349741000640 Beta-Casp domain; Region: Beta-Casp; smart01027 349741000641 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 349741000642 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 349741000643 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741000644 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741000645 Sel1-like repeats; Region: SEL1; smart00671 349741000646 Sel1-like repeats; Region: SEL1; smart00671 349741000647 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 349741000648 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349741000649 RNA binding surface [nucleotide binding]; other site 349741000650 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 349741000651 active site 349741000652 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 349741000653 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 349741000654 peptide chain release factor 2; Provisional; Region: PRK05589 349741000655 This domain is found in peptide chain release factors; Region: PCRF; smart00937 349741000656 RF-1 domain; Region: RF-1; pfam00472 349741000657 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 349741000658 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 349741000659 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 349741000660 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 349741000661 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 349741000662 RNA binding site [nucleotide binding]; other site 349741000663 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 349741000664 RNA binding site [nucleotide binding]; other site 349741000665 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 349741000666 RNA binding site [nucleotide binding]; other site 349741000667 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349741000668 RNA binding site [nucleotide binding]; other site 349741000669 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 349741000670 RNA binding site [nucleotide binding]; other site 349741000671 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 349741000672 RNA binding site [nucleotide binding]; other site 349741000673 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 349741000674 putative FMN binding site [chemical binding]; other site 349741000675 NADPH bind site [chemical binding]; other site 349741000676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741000677 Coenzyme A binding pocket [chemical binding]; other site 349741000678 PA14 domain; Region: PA14; cl08459 349741000679 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 349741000680 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 349741000681 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 349741000682 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 349741000683 Peptidase family M23; Region: Peptidase_M23; pfam01551 349741000684 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 349741000685 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 349741000686 active site 349741000687 oligomerization interface [polypeptide binding]; other site 349741000688 metal binding site [ion binding]; metal-binding site 349741000689 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 349741000690 catalytic center binding site [active] 349741000691 ATP binding site [chemical binding]; other site 349741000692 dihydrodipicolinate reductase; Provisional; Region: PRK00048 349741000693 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 349741000694 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 349741000695 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 349741000696 dihydrodipicolinate synthase; Region: dapA; TIGR00674 349741000697 dimer interface [polypeptide binding]; other site 349741000698 active site 349741000699 catalytic residue [active] 349741000700 short chain dehydrogenase; Validated; Region: PRK06484 349741000701 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 349741000702 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741000703 catalytic residues [active] 349741000704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741000705 binding surface 349741000706 TPR motif; other site 349741000707 amine oxidase (copper-containing); Region: PLN02566 349741000708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 349741000709 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 349741000710 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 349741000711 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349741000712 Zn2+ binding site [ion binding]; other site 349741000713 Mg2+ binding site [ion binding]; other site 349741000714 putative phosphate acyltransferase; Provisional; Region: PRK05331 349741000715 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 349741000716 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 349741000717 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 349741000718 nucleotide binding site/active site [active] 349741000719 HIT family signature motif; other site 349741000720 catalytic residue [active] 349741000721 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 349741000722 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 349741000723 shikimate kinase; Reviewed; Region: aroK; PRK00131 349741000724 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 349741000725 ADP binding site [chemical binding]; other site 349741000726 magnesium binding site [ion binding]; other site 349741000727 putative shikimate binding site; other site 349741000728 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 349741000729 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 349741000730 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349741000731 active site 349741000732 DNA binding site [nucleotide binding] 349741000733 Int/Topo IB signature motif; other site 349741000734 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 349741000735 Ca2+ binding site [ion binding]; other site 349741000736 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 349741000737 Ca2+ binding site [ion binding]; other site 349741000738 Preprotein translocase subunit; Region: YajC; pfam02699 349741000739 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 349741000740 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 349741000741 Putative methyltransferase; Region: Methyltransf_4; cl17290 349741000742 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349741000743 nudix motif; other site 349741000744 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 349741000745 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 349741000746 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 349741000747 ribonuclease HIII; Provisional; Region: PRK00996 349741000748 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 349741000749 RNA/DNA hybrid binding site [nucleotide binding]; other site 349741000750 active site 349741000751 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 349741000752 IHF - DNA interface [nucleotide binding]; other site 349741000753 IHF dimer interface [polypeptide binding]; other site 349741000754 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 349741000755 SurA N-terminal domain; Region: SurA_N_3; cl07813 349741000756 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 349741000757 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741000758 sugar binding site [chemical binding]; other site 349741000759 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 349741000760 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 349741000761 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349741000762 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 349741000763 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 349741000764 HIGH motif; other site 349741000765 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 349741000766 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 349741000767 active site 349741000768 KMSKS motif; other site 349741000769 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 349741000770 tRNA binding surface [nucleotide binding]; other site 349741000771 anticodon binding site; other site 349741000772 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 349741000773 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 349741000774 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 349741000775 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 349741000776 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 349741000777 23S rRNA interface [nucleotide binding]; other site 349741000778 putative translocon interaction site; other site 349741000779 signal recognition particle (SRP54) interaction site; other site 349741000780 L23 interface [polypeptide binding]; other site 349741000781 trigger factor interaction site; other site 349741000782 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 349741000783 23S rRNA interface [nucleotide binding]; other site 349741000784 5S rRNA interface [nucleotide binding]; other site 349741000785 putative antibiotic binding site [chemical binding]; other site 349741000786 L25 interface [polypeptide binding]; other site 349741000787 L27 interface [polypeptide binding]; other site 349741000788 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 349741000789 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 349741000790 G-X-X-G motif; other site 349741000791 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 349741000792 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 349741000793 putative translocon binding site; other site 349741000794 protein-rRNA interface [nucleotide binding]; other site 349741000795 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 349741000796 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 349741000797 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 349741000798 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 349741000799 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 349741000800 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 349741000801 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 349741000802 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 349741000803 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 349741000804 elongation factor G; Reviewed; Region: PRK00007 349741000805 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 349741000806 G1 box; other site 349741000807 putative GEF interaction site [polypeptide binding]; other site 349741000808 GTP/Mg2+ binding site [chemical binding]; other site 349741000809 Switch I region; other site 349741000810 G2 box; other site 349741000811 G3 box; other site 349741000812 Switch II region; other site 349741000813 G4 box; other site 349741000814 G5 box; other site 349741000815 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 349741000816 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 349741000817 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 349741000818 30S ribosomal protein S7; Validated; Region: PRK05302 349741000819 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 349741000820 S17 interaction site [polypeptide binding]; other site 349741000821 S8 interaction site; other site 349741000822 16S rRNA interaction site [nucleotide binding]; other site 349741000823 streptomycin interaction site [chemical binding]; other site 349741000824 23S rRNA interaction site [nucleotide binding]; other site 349741000825 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 349741000826 phosphoglyceromutase; Provisional; Region: PRK05434 349741000827 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 349741000828 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 349741000829 active site 349741000830 PAS domain; Region: PAS; smart00091 349741000831 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 349741000832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349741000833 dimer interface [polypeptide binding]; other site 349741000834 phosphorylation site [posttranslational modification] 349741000835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741000836 ATP binding site [chemical binding]; other site 349741000837 Mg2+ binding site [ion binding]; other site 349741000838 G-X-G motif; other site 349741000839 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 349741000840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349741000841 active site 349741000842 phosphorylation site [posttranslational modification] 349741000843 intermolecular recognition site; other site 349741000844 dimerization interface [polypeptide binding]; other site 349741000845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741000846 Walker A motif; other site 349741000847 ATP binding site [chemical binding]; other site 349741000848 Walker B motif; other site 349741000849 arginine finger; other site 349741000850 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 349741000851 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 349741000852 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 349741000853 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 349741000854 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 349741000855 TPP-binding site; other site 349741000856 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 349741000857 PYR/PP interface [polypeptide binding]; other site 349741000858 dimer interface [polypeptide binding]; other site 349741000859 TPP binding site [chemical binding]; other site 349741000860 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 349741000861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741000862 binding surface 349741000863 TPR motif; other site 349741000864 TPR repeat; Region: TPR_11; pfam13414 349741000865 Recombination protein O N terminal; Region: RecO_N; pfam11967 349741000866 Recombination protein O C terminal; Region: RecO_C; pfam02565 349741000867 Predicted permeases [General function prediction only]; Region: COG0795 349741000868 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 349741000869 GTP-binding protein Der; Reviewed; Region: PRK00093 349741000870 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 349741000871 G1 box; other site 349741000872 GTP/Mg2+ binding site [chemical binding]; other site 349741000873 Switch I region; other site 349741000874 G2 box; other site 349741000875 Switch II region; other site 349741000876 G3 box; other site 349741000877 G4 box; other site 349741000878 G5 box; other site 349741000879 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 349741000880 G1 box; other site 349741000881 GTP/Mg2+ binding site [chemical binding]; other site 349741000882 Switch I region; other site 349741000883 G2 box; other site 349741000884 G3 box; other site 349741000885 Switch II region; other site 349741000886 G4 box; other site 349741000887 G5 box; other site 349741000888 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 349741000889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 349741000890 Walker A/P-loop; other site 349741000891 ATP binding site [chemical binding]; other site 349741000892 Q-loop/lid; other site 349741000893 ABC transporter signature motif; other site 349741000894 Walker B; other site 349741000895 D-loop; other site 349741000896 H-loop/switch region; other site 349741000897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 349741000898 Helix-turn-helix domain; Region: HTH_17; pfam12728 349741000899 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 349741000900 Divergent AAA domain; Region: AAA_4; pfam04326 349741000901 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 349741000902 MarR family; Region: MarR_2; pfam12802 349741000903 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 349741000904 Chloramphenicol acetyltransferase; Region: CAT; cl02008 349741000905 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 349741000906 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 349741000907 FtsX-like permease family; Region: FtsX; pfam02687 349741000908 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349741000909 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349741000910 Walker A/P-loop; other site 349741000911 ATP binding site [chemical binding]; other site 349741000912 Q-loop/lid; other site 349741000913 ABC transporter signature motif; other site 349741000914 Walker B; other site 349741000915 D-loop; other site 349741000916 H-loop/switch region; other site 349741000917 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 349741000918 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 349741000919 N-terminal plug; other site 349741000920 ligand-binding site [chemical binding]; other site 349741000921 prephenate dehydrogenase; Validated; Region: PRK08507 349741000922 Prephenate dehydrogenase; Region: PDH; pfam02153 349741000923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741000924 putative substrate translocation pore; other site 349741000925 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 349741000926 putative acyl-acceptor binding pocket; other site 349741000927 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 349741000928 active site 349741000929 Zn binding site [ion binding]; other site 349741000930 OsmC-like protein; Region: OsmC; pfam02566 349741000931 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 349741000932 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 349741000933 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 349741000934 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741000935 active site 349741000936 catalytic triad [active] 349741000937 oxyanion hole [active] 349741000938 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 349741000939 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 349741000940 active site 349741000941 catalytic site [active] 349741000942 substrate binding site [chemical binding]; other site 349741000943 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 349741000944 MutS domain I; Region: MutS_I; pfam01624 349741000945 MutS domain II; Region: MutS_II; pfam05188 349741000946 MutS domain III; Region: MutS_III; pfam05192 349741000947 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 349741000948 Walker A/P-loop; other site 349741000949 ATP binding site [chemical binding]; other site 349741000950 Q-loop/lid; other site 349741000951 ABC transporter signature motif; other site 349741000952 Walker B; other site 349741000953 D-loop; other site 349741000954 H-loop/switch region; other site 349741000955 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 349741000956 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 349741000957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741000958 Walker A motif; other site 349741000959 ATP binding site [chemical binding]; other site 349741000960 Walker B motif; other site 349741000961 arginine finger; other site 349741000962 Peptidase family M41; Region: Peptidase_M41; pfam01434 349741000963 putative inner membrane protein translocase component YidC; Validated; Region: PRK00247 349741000964 AAA domain; Region: AAA_21; pfam13304 349741000965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741000966 Walker B; other site 349741000967 D-loop; other site 349741000968 H-loop/switch region; other site 349741000969 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 349741000970 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 349741000971 substrate binding site [chemical binding]; other site 349741000972 oxyanion hole (OAH) forming residues; other site 349741000973 trimer interface [polypeptide binding]; other site 349741000974 FtsX-like permease family; Region: FtsX; pfam02687 349741000975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741000976 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 349741000977 Walker A/P-loop; other site 349741000978 ATP binding site [chemical binding]; other site 349741000979 Q-loop/lid; other site 349741000980 ABC transporter signature motif; other site 349741000981 Walker B; other site 349741000982 D-loop; other site 349741000983 H-loop/switch region; other site 349741000984 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741000985 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349741000986 Walker A/P-loop; other site 349741000987 ATP binding site [chemical binding]; other site 349741000988 Q-loop/lid; other site 349741000989 ABC transporter signature motif; other site 349741000990 Walker B; other site 349741000991 D-loop; other site 349741000992 H-loop/switch region; other site 349741000993 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 349741000994 short chain dehydrogenase; Provisional; Region: PRK06181 349741000995 classical (c) SDRs; Region: SDR_c; cd05233 349741000996 NAD(P) binding site [chemical binding]; other site 349741000997 active site 349741000998 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 349741000999 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 349741001000 substrate binding pocket [chemical binding]; other site 349741001001 substrate-Mg2+ binding site; other site 349741001002 aspartate-rich region 1; other site 349741001003 aspartate-rich region 2; other site 349741001004 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 349741001005 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 349741001006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741001007 Walker A motif; other site 349741001008 ATP binding site [chemical binding]; other site 349741001009 Walker B motif; other site 349741001010 arginine finger; other site 349741001011 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 349741001012 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 349741001013 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 349741001014 Cl- selectivity filter; other site 349741001015 Cl- binding residues [ion binding]; other site 349741001016 pore gating glutamate residue; other site 349741001017 dimer interface [polypeptide binding]; other site 349741001018 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 349741001019 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741001020 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741001021 active site 349741001022 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 349741001023 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 349741001024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741001025 catalytic residue [active] 349741001026 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 349741001027 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 349741001028 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 349741001029 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 349741001030 active site 349741001031 PHP Thumb interface [polypeptide binding]; other site 349741001032 metal binding site [ion binding]; metal-binding site 349741001033 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 349741001034 generic binding surface I; other site 349741001035 generic binding surface II; other site 349741001036 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 349741001037 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 349741001038 quinone interaction residues [chemical binding]; other site 349741001039 active site 349741001040 catalytic residues [active] 349741001041 FMN binding site [chemical binding]; other site 349741001042 substrate binding site [chemical binding]; other site 349741001043 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 349741001044 thiamine phosphate binding site [chemical binding]; other site 349741001045 active site 349741001046 pyrophosphate binding site [ion binding]; other site 349741001047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349741001048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349741001049 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 349741001050 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 349741001051 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741001052 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 349741001053 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 349741001054 HEAT repeats; Region: HEAT_2; pfam13646 349741001055 TPR repeat; Region: TPR_11; pfam13414 349741001056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741001057 binding surface 349741001058 TPR motif; other site 349741001059 TPR repeat; Region: TPR_11; pfam13414 349741001060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741001061 binding surface 349741001062 TPR motif; other site 349741001063 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 349741001064 Domain of unknown function DUF21; Region: DUF21; pfam01595 349741001065 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 349741001066 Transporter associated domain; Region: CorC_HlyC; smart01091 349741001067 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 349741001068 Domain of unknown function DUF21; Region: DUF21; pfam01595 349741001069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 349741001070 Transporter associated domain; Region: CorC_HlyC; smart01091 349741001071 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 349741001072 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 349741001073 RNase E interface [polypeptide binding]; other site 349741001074 trimer interface [polypeptide binding]; other site 349741001075 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 349741001076 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 349741001077 RNase E interface [polypeptide binding]; other site 349741001078 trimer interface [polypeptide binding]; other site 349741001079 active site 349741001080 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 349741001081 putative nucleic acid binding region [nucleotide binding]; other site 349741001082 G-X-X-G motif; other site 349741001083 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 349741001084 RNA binding site [nucleotide binding]; other site 349741001085 domain interface; other site 349741001086 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 349741001087 16S/18S rRNA binding site [nucleotide binding]; other site 349741001088 S13e-L30e interaction site [polypeptide binding]; other site 349741001089 25S rRNA binding site [nucleotide binding]; other site 349741001090 maltose O-acetyltransferase; Provisional; Region: PRK10092 349741001091 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 349741001092 active site 349741001093 substrate binding site [chemical binding]; other site 349741001094 trimer interface [polypeptide binding]; other site 349741001095 CoA binding site [chemical binding]; other site 349741001096 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741001097 Terminase-like family; Region: Terminase_6; pfam03237 349741001098 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 349741001099 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 349741001100 dimerization interface 3.5A [polypeptide binding]; other site 349741001101 active site 349741001102 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 349741001103 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 349741001104 active site 349741001105 (T/H)XGH motif; other site 349741001106 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 349741001107 Peptidase family M23; Region: Peptidase_M23; pfam01551 349741001108 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 349741001109 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 349741001110 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741001111 Fn3 associated; Region: Fn3_assoc; pfam13287 349741001112 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741001113 sugar binding site [chemical binding]; other site 349741001114 ribonuclease PH; Reviewed; Region: rph; PRK00173 349741001115 Ribonuclease PH; Region: RNase_PH_bact; cd11362 349741001116 hexamer interface [polypeptide binding]; other site 349741001117 active site 349741001118 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 349741001119 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 349741001120 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741001121 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cd02742 349741001122 active site 349741001123 AAA domain; Region: AAA_26; pfam13500 349741001124 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 349741001125 Uncharacterized conserved protein [Function unknown]; Region: COG1624 349741001126 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 349741001127 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349741001128 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 349741001129 Walker A/P-loop; other site 349741001130 ATP binding site [chemical binding]; other site 349741001131 Q-loop/lid; other site 349741001132 ABC transporter signature motif; other site 349741001133 Walker B; other site 349741001134 D-loop; other site 349741001135 H-loop/switch region; other site 349741001136 Pantoate-beta-alanine ligase; Region: PanC; cd00560 349741001137 pantoate--beta-alanine ligase; Region: panC; TIGR00018 349741001138 active site 349741001139 ATP-binding site [chemical binding]; other site 349741001140 pantoate-binding site; other site 349741001141 HXXH motif; other site 349741001142 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 349741001143 periplasmic chaperone; Provisional; Region: PRK10780 349741001144 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 349741001145 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 349741001146 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 349741001147 trimer interface [polypeptide binding]; other site 349741001148 active site 349741001149 UDP-GlcNAc binding site [chemical binding]; other site 349741001150 lipid binding site [chemical binding]; lipid-binding site 349741001151 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 349741001152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741001153 dimer interface [polypeptide binding]; other site 349741001154 conserved gate region; other site 349741001155 putative PBP binding loops; other site 349741001156 ABC-ATPase subunit interface; other site 349741001157 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 349741001158 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 349741001159 Walker A/P-loop; other site 349741001160 ATP binding site [chemical binding]; other site 349741001161 Q-loop/lid; other site 349741001162 ABC transporter signature motif; other site 349741001163 Walker B; other site 349741001164 D-loop; other site 349741001165 H-loop/switch region; other site 349741001166 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 349741001167 NMT1-like family; Region: NMT1_2; pfam13379 349741001168 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 349741001169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741001170 active site 349741001171 motif I; other site 349741001172 motif II; other site 349741001173 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 349741001174 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 349741001175 dimer interface [polypeptide binding]; other site 349741001176 active site 349741001177 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 349741001178 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 349741001179 putative ribose interaction site [chemical binding]; other site 349741001180 putative ADP binding site [chemical binding]; other site 349741001181 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 349741001182 active site 349741001183 nucleotide binding site [chemical binding]; other site 349741001184 HIGH motif; other site 349741001185 KMSKS motif; other site 349741001186 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 349741001187 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 349741001188 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 349741001189 inhibitor-cofactor binding pocket; inhibition site 349741001190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741001191 catalytic residue [active] 349741001192 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 349741001193 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 349741001194 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 349741001195 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 349741001196 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 349741001197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741001198 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 349741001199 HEAT repeats; Region: HEAT_2; pfam13646 349741001200 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 349741001201 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741001202 active site 349741001203 HIGH motif; other site 349741001204 nucleotide binding site [chemical binding]; other site 349741001205 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 349741001206 KMSKS motif; other site 349741001207 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 349741001208 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 349741001209 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 349741001210 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 349741001211 dimerization interface [polypeptide binding]; other site 349741001212 active site 349741001213 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 349741001214 homopentamer interface [polypeptide binding]; other site 349741001215 active site 349741001216 transcription antitermination factor NusB; Region: nusB; TIGR01951 349741001217 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 349741001218 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 349741001219 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349741001220 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 349741001221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741001222 FeS/SAM binding site; other site 349741001223 replicative DNA helicase; Region: DnaB; TIGR00665 349741001224 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 349741001225 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 349741001226 Walker A motif; other site 349741001227 ATP binding site [chemical binding]; other site 349741001228 Walker B motif; other site 349741001229 DNA binding loops [nucleotide binding] 349741001230 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 349741001231 competence damage-inducible protein A; Provisional; Region: PRK00549 349741001232 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 349741001233 putative MPT binding site; other site 349741001234 Competence-damaged protein; Region: CinA; pfam02464 349741001235 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 349741001236 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 349741001237 domain interfaces; other site 349741001238 active site 349741001239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741001240 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349741001241 Coenzyme A binding pocket [chemical binding]; other site 349741001242 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 349741001243 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 349741001244 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 349741001245 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 349741001246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349741001247 RNA binding surface [nucleotide binding]; other site 349741001248 30S ribosomal protein S11; Validated; Region: PRK05309 349741001249 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 349741001250 30S ribosomal protein S13; Region: bact_S13; TIGR03631 349741001251 epoxyqueuosine reductase; Region: TIGR00276 349741001252 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 349741001253 Predicted nucleoside-diphosphate-sugar epimerase [Cell envelope biogenesis, outer membrane]; Region: COG3660 349741001254 Mitochondrial fission ELM1; Region: Mito_fiss_Elm1; pfam06258 349741001255 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741001256 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 349741001257 putative ADP-binding pocket [chemical binding]; other site 349741001258 DNA protecting protein DprA; Region: dprA; TIGR00732 349741001259 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 349741001260 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 349741001261 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 349741001262 GTP-binding protein YchF; Reviewed; Region: PRK09601 349741001263 YchF GTPase; Region: YchF; cd01900 349741001264 G1 box; other site 349741001265 GTP/Mg2+ binding site [chemical binding]; other site 349741001266 Switch I region; other site 349741001267 G2 box; other site 349741001268 Switch II region; other site 349741001269 G3 box; other site 349741001270 G4 box; other site 349741001271 G5 box; other site 349741001272 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 349741001273 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 349741001274 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 349741001275 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 349741001276 lipoyl attachment site [posttranslational modification]; other site 349741001277 glycine dehydrogenase; Provisional; Region: PRK05367 349741001278 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 349741001279 tetramer interface [polypeptide binding]; other site 349741001280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741001281 catalytic residue [active] 349741001282 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 349741001283 tetramer interface [polypeptide binding]; other site 349741001284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741001285 catalytic residue [active] 349741001286 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741001287 Protein of unknown function (DUF805); Region: DUF805; pfam05656 349741001288 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741001289 Sulfatase; Region: Sulfatase; pfam00884 349741001290 PA14 domain; Region: PA14; cl08459 349741001291 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 349741001292 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 349741001293 ATP binding site [chemical binding]; other site 349741001294 Mg++ binding site [ion binding]; other site 349741001295 motif III; other site 349741001296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741001297 nucleotide binding region [chemical binding]; other site 349741001298 ATP-binding site [chemical binding]; other site 349741001299 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 349741001300 RNA binding site [nucleotide binding]; other site 349741001301 Domain of unknown function (DUF303); Region: DUF303; pfam03629 349741001302 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741001303 active site 349741001304 catalytic triad [active] 349741001305 oxyanion hole [active] 349741001306 Lamin Tail Domain; Region: LTD; pfam00932 349741001307 DoxX; Region: DoxX; pfam07681 349741001308 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 349741001309 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 349741001310 dimerization interface [polypeptide binding]; other site 349741001311 putative ATP binding site [chemical binding]; other site 349741001312 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 349741001313 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 349741001314 active site 349741001315 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 349741001316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349741001317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 349741001318 DNA binding residues [nucleotide binding] 349741001319 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 349741001320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741001321 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 349741001322 Flavoprotein; Region: Flavoprotein; pfam02441 349741001323 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 349741001324 Peptidase family M23; Region: Peptidase_M23; pfam01551 349741001325 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349741001326 nudix motif; other site 349741001327 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 349741001328 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 349741001329 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 349741001330 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 349741001331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741001332 Coenzyme A binding pocket [chemical binding]; other site 349741001333 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 349741001334 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 349741001335 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741001336 catalytic residue [active] 349741001337 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 349741001338 GTPase RsgA; Reviewed; Region: PRK01889 349741001339 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349741001340 RNA binding site [nucleotide binding]; other site 349741001341 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 349741001342 GTPase/Zn-binding domain interface [polypeptide binding]; other site 349741001343 GTP/Mg2+ binding site [chemical binding]; other site 349741001344 G4 box; other site 349741001345 G5 box; other site 349741001346 G1 box; other site 349741001347 Switch I region; other site 349741001348 G2 box; other site 349741001349 G3 box; other site 349741001350 Switch II region; other site 349741001351 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 349741001352 catalytic motif [active] 349741001353 Catalytic residue [active] 349741001354 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 349741001355 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 349741001356 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741001357 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 349741001358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741001359 S-adenosylmethionine binding site [chemical binding]; other site 349741001360 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 349741001361 NPCBM/NEW2 domain; Region: NPCBM; cl07060 349741001362 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 349741001363 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 349741001364 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 349741001365 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 349741001366 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 349741001367 metal binding site 2 [ion binding]; metal-binding site 349741001368 putative DNA binding helix; other site 349741001369 metal binding site 1 [ion binding]; metal-binding site 349741001370 dimer interface [polypeptide binding]; other site 349741001371 structural Zn2+ binding site [ion binding]; other site 349741001372 FeS assembly ATPase SufC; Region: sufC; TIGR01978 349741001373 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 349741001374 Walker A/P-loop; other site 349741001375 ATP binding site [chemical binding]; other site 349741001376 Q-loop/lid; other site 349741001377 ABC transporter signature motif; other site 349741001378 Walker B; other site 349741001379 D-loop; other site 349741001380 H-loop/switch region; other site 349741001381 FeS assembly protein SufB; Region: sufB; TIGR01980 349741001382 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 349741001383 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 349741001384 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 349741001385 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 349741001386 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741001387 Sulfatase; Region: Sulfatase; pfam00884 349741001388 biotin synthase; Region: bioB; TIGR00433 349741001389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741001390 FeS/SAM binding site; other site 349741001391 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 349741001392 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 349741001393 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 349741001394 inhibitor-cofactor binding pocket; inhibition site 349741001395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741001396 catalytic residue [active] 349741001397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 349741001398 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 349741001399 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 349741001400 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 349741001401 Ligand binding site; other site 349741001402 Putative Catalytic site; other site 349741001403 DXD motif; other site 349741001404 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 349741001405 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 349741001406 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 349741001407 inhibitor-cofactor binding pocket; inhibition site 349741001408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741001409 catalytic residue [active] 349741001410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 349741001411 SprT-like family; Region: SprT-like; pfam10263 349741001412 SprT homologues; Region: SprT; cl01182 349741001413 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 349741001414 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 349741001415 gamma subunit interface [polypeptide binding]; other site 349741001416 epsilon subunit interface [polypeptide binding]; other site 349741001417 LBP interface [polypeptide binding]; other site 349741001418 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 349741001419 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 349741001420 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 349741001421 alpha subunit interaction interface [polypeptide binding]; other site 349741001422 Walker A motif; other site 349741001423 ATP binding site [chemical binding]; other site 349741001424 Walker B motif; other site 349741001425 inhibitor binding site; inhibition site 349741001426 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 349741001427 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 349741001428 core domain interface [polypeptide binding]; other site 349741001429 delta subunit interface [polypeptide binding]; other site 349741001430 epsilon subunit interface [polypeptide binding]; other site 349741001431 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 349741001432 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 349741001433 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 349741001434 beta subunit interaction interface [polypeptide binding]; other site 349741001435 Walker A motif; other site 349741001436 ATP binding site [chemical binding]; other site 349741001437 Walker B motif; other site 349741001438 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 349741001439 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 349741001440 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 349741001441 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 349741001442 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 349741001443 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 349741001444 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 349741001445 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 349741001446 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 349741001447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 349741001448 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741001449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 349741001450 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684 349741001451 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 349741001452 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 349741001453 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 349741001454 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 349741001455 ATP binding site [chemical binding]; other site 349741001456 substrate interface [chemical binding]; other site 349741001457 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 349741001458 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 349741001459 putative active site [active] 349741001460 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 349741001461 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 349741001462 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741001463 Predicted membrane protein [Function unknown]; Region: COG2259 349741001464 serine acetyltransferase; Provisional; Region: cysE; PRK11132 349741001465 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 349741001466 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 349741001467 trimer interface [polypeptide binding]; other site 349741001468 active site 349741001469 substrate binding site [chemical binding]; other site 349741001470 CoA binding site [chemical binding]; other site 349741001471 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 349741001472 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 349741001473 putative catalytic cysteine [active] 349741001474 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 349741001475 nucleotide binding site [chemical binding]; other site 349741001476 homotetrameric interface [polypeptide binding]; other site 349741001477 putative phosphate binding site [ion binding]; other site 349741001478 putative allosteric binding site; other site 349741001479 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 349741001480 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 349741001481 TPP-binding site [chemical binding]; other site 349741001482 dimer interface [polypeptide binding]; other site 349741001483 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 349741001484 PYR/PP interface [polypeptide binding]; other site 349741001485 dimer interface [polypeptide binding]; other site 349741001486 TPP binding site [chemical binding]; other site 349741001487 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 349741001488 transcription elongation factor GreA; Region: greA; TIGR01462 349741001489 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 349741001490 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 349741001491 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 349741001492 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 349741001493 ATP binding site [chemical binding]; other site 349741001494 active site 349741001495 substrate binding site [chemical binding]; other site 349741001496 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 349741001497 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 349741001498 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 349741001499 dimerization interface [polypeptide binding]; other site 349741001500 ATP binding site [chemical binding]; other site 349741001501 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 349741001502 dimerization interface [polypeptide binding]; other site 349741001503 ATP binding site [chemical binding]; other site 349741001504 Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: PurL; COG0047 349741001505 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 349741001506 conserved cys residue [active] 349741001507 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 349741001508 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 349741001509 oligomer interface [polypeptide binding]; other site 349741001510 active site 349741001511 metal binding site [ion binding]; metal-binding site 349741001512 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 349741001513 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 349741001514 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349741001515 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 349741001516 rod shape-determining protein MreB; Provisional; Region: PRK13927 349741001517 MreB and similar proteins; Region: MreB_like; cd10225 349741001518 nucleotide binding site [chemical binding]; other site 349741001519 Mg binding site [ion binding]; other site 349741001520 putative protofilament interaction site [polypeptide binding]; other site 349741001521 RodZ interaction site [polypeptide binding]; other site 349741001522 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 349741001523 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 349741001524 homodimer interface [polypeptide binding]; other site 349741001525 oligonucleotide binding site [chemical binding]; other site 349741001526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741001527 TPR motif; other site 349741001528 binding surface 349741001529 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 349741001530 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741001531 binding surface 349741001532 TPR motif; other site 349741001533 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 349741001534 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 349741001535 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 349741001536 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 349741001537 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 349741001538 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 349741001539 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 349741001540 minor groove reading motif; other site 349741001541 helix-hairpin-helix signature motif; other site 349741001542 substrate binding pocket [chemical binding]; other site 349741001543 active site 349741001544 3D domain; Region: 3D; cl01439 349741001545 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 349741001546 Fe-S cluster binding site [ion binding]; other site 349741001547 active site 349741001548 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 349741001549 phosphate binding site [ion binding]; other site 349741001550 hypothetical protein; Reviewed; Region: PRK12497 349741001551 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 349741001552 RNA/DNA hybrid binding site [nucleotide binding]; other site 349741001553 active site 349741001554 Domain of unknown function DUF21; Region: DUF21; pfam01595 349741001555 FOG: CBS domain [General function prediction only]; Region: COG0517 349741001556 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 349741001557 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 349741001558 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 349741001559 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 349741001560 argininosuccinate synthase; Provisional; Region: PRK13820 349741001561 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 349741001562 ANP binding site [chemical binding]; other site 349741001563 Substrate Binding Site II [chemical binding]; other site 349741001564 Substrate Binding Site I [chemical binding]; other site 349741001565 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 349741001566 putative RNA binding site [nucleotide binding]; other site 349741001567 16S rRNA methyltransferase B; Provisional; Region: PRK14902 349741001568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741001569 S-adenosylmethionine binding site [chemical binding]; other site 349741001570 triosephosphate isomerase; Provisional; Region: PRK14567 349741001571 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 349741001572 substrate binding site [chemical binding]; other site 349741001573 dimer interface [polypeptide binding]; other site 349741001574 catalytic triad [active] 349741001575 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741001576 Sulfatase; Region: Sulfatase; pfam00884 349741001577 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 349741001578 active site 349741001579 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 349741001580 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349741001581 active site 349741001582 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 349741001583 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 349741001584 homodimer interface [polypeptide binding]; other site 349741001585 metal binding site [ion binding]; metal-binding site 349741001586 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 349741001587 homodimer interface [polypeptide binding]; other site 349741001588 active site 349741001589 putative chemical substrate binding site [chemical binding]; other site 349741001590 metal binding site [ion binding]; metal-binding site 349741001591 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 349741001592 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 349741001593 catalytic site [active] 349741001594 putative active site [active] 349741001595 putative substrate binding site [chemical binding]; other site 349741001596 HRDC domain; Region: HRDC; cl02578 349741001597 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 349741001598 Putative zinc ribbon domain; Region: DUF164; pfam02591 349741001599 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 349741001600 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 349741001601 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 349741001602 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 349741001603 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 349741001604 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 349741001605 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 349741001606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 349741001607 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 349741001608 diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921 349741001609 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349741001610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 349741001611 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741001612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 349741001613 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 349741001614 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741001615 threonine dehydratase; Reviewed; Region: PRK09224 349741001616 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 349741001617 tetramer interface [polypeptide binding]; other site 349741001618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741001619 catalytic residue [active] 349741001620 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 349741001621 Maf-like protein; Region: Maf; pfam02545 349741001622 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 349741001623 active site 349741001624 dimer interface [polypeptide binding]; other site 349741001625 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 349741001626 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 349741001627 HflX GTPase family; Region: HflX; cd01878 349741001628 G1 box; other site 349741001629 GTP/Mg2+ binding site [chemical binding]; other site 349741001630 Switch I region; other site 349741001631 G2 box; other site 349741001632 G3 box; other site 349741001633 Switch II region; other site 349741001634 G4 box; other site 349741001635 G5 box; other site 349741001636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 349741001637 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349741001638 active site 349741001639 ATP binding site [chemical binding]; other site 349741001640 substrate binding site [chemical binding]; other site 349741001641 activation loop (A-loop); other site 349741001642 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 349741001643 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349741001644 nucleotide binding site [chemical binding]; other site 349741001645 CAAX protease self-immunity; Region: Abi; pfam02517 349741001646 thiamine monophosphate kinase; Provisional; Region: PRK05731 349741001647 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 349741001648 ATP binding site [chemical binding]; other site 349741001649 dimerization interface [polypeptide binding]; other site 349741001650 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 349741001651 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 349741001652 putative acyl-acceptor binding pocket; other site 349741001653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 349741001654 cytidylate kinase; Provisional; Region: cmk; PRK00023 349741001655 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 349741001656 CMP-binding site; other site 349741001657 The sites determining sugar specificity; other site 349741001658 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 349741001659 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 349741001660 putative acyl-acceptor binding pocket; other site 349741001661 recombination protein F; Reviewed; Region: recF; PRK00064 349741001662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741001663 Walker A/P-loop; other site 349741001664 ATP binding site [chemical binding]; other site 349741001665 Q-loop/lid; other site 349741001666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741001667 ABC transporter signature motif; other site 349741001668 Walker B; other site 349741001669 D-loop; other site 349741001670 H-loop/switch region; other site 349741001671 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 349741001672 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 349741001673 dimerization interface [polypeptide binding]; other site 349741001674 active site 349741001675 metal binding site [ion binding]; metal-binding site 349741001676 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 349741001677 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 349741001678 active site 349741001679 catalytic residues [active] 349741001680 DNA binding site [nucleotide binding] 349741001681 Int/Topo IB signature motif; other site 349741001682 MORN repeat; Region: MORN; cl14787 349741001683 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 349741001684 UvrB/uvrC motif; Region: UVR; pfam02151 349741001685 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 349741001686 putative catalytic site [active] 349741001687 putative metal binding site [ion binding]; other site 349741001688 putative phosphate binding site [ion binding]; other site 349741001689 Predicted methyltransferases [General function prediction only]; Region: COG0313 349741001690 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 349741001691 putative SAM binding site [chemical binding]; other site 349741001692 putative homodimer interface [polypeptide binding]; other site 349741001693 Lipopolysaccharide-assembly; Region: LptE; cl01125 349741001694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741001695 binding surface 349741001696 Tetratricopeptide repeat; Region: TPR_16; pfam13432 349741001697 TPR motif; other site 349741001698 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 349741001699 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 349741001700 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 349741001701 DNA polymerase III subunit delta'; Validated; Region: PRK06964 349741001702 DNA polymerase III subunit delta'; Validated; Region: PRK08485 349741001703 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 349741001704 putative active site [active] 349741001705 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 349741001706 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349741001707 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349741001708 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 349741001709 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349741001710 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349741001711 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 349741001712 IMP binding site; other site 349741001713 dimer interface [polypeptide binding]; other site 349741001714 interdomain contacts; other site 349741001715 partial ornithine binding site; other site 349741001716 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 349741001717 active site 349741001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741001719 S-adenosylmethionine binding site [chemical binding]; other site 349741001720 NAD synthetase; Reviewed; Region: nadE; PRK02628 349741001721 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 349741001722 multimer interface [polypeptide binding]; other site 349741001723 active site 349741001724 catalytic triad [active] 349741001725 protein interface 1 [polypeptide binding]; other site 349741001726 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 349741001727 homodimer interface [polypeptide binding]; other site 349741001728 NAD binding pocket [chemical binding]; other site 349741001729 ATP binding pocket [chemical binding]; other site 349741001730 Mg binding site [ion binding]; other site 349741001731 active-site loop [active] 349741001732 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 349741001733 PEP-CTERM motif; Region: VPEP; pfam07589 349741001734 BNR repeat-like domain; Region: BNR_2; pfam13088 349741001735 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 349741001736 Asp-box motif; other site 349741001737 catalytic site [active] 349741001738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349741001739 DNA-binding site [nucleotide binding]; DNA binding site 349741001740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349741001741 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 349741001742 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 349741001743 catalytic site [active] 349741001744 BNR repeat-like domain; Region: BNR_2; pfam13088 349741001745 Asp-box motif; other site 349741001746 Peptidase M60-like family; Region: M60-like; pfam13402 349741001747 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 349741001748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741001749 Walker A motif; other site 349741001750 ATP binding site [chemical binding]; other site 349741001751 Walker B motif; other site 349741001752 arginine finger; other site 349741001753 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 349741001754 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 349741001755 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 349741001756 dimer interface [polypeptide binding]; other site 349741001757 active site 349741001758 CoA binding pocket [chemical binding]; other site 349741001759 FAD binding domain; Region: FAD_binding_1; pfam00667 349741001760 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 349741001761 FAD binding pocket [chemical binding]; other site 349741001762 FAD binding motif [chemical binding]; other site 349741001763 catalytic residues [active] 349741001764 NAD binding pocket [chemical binding]; other site 349741001765 phosphate binding motif [ion binding]; other site 349741001766 beta-alpha-beta structure motif; other site 349741001767 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 349741001768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741001769 active site 349741001770 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741001771 active site 349741001772 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 349741001773 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 349741001774 Ligand binding site; other site 349741001775 metal-binding site 349741001776 type III secretion system chaperone YscW; Region: YscW; TIGR02567 349741001777 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 349741001778 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741001779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741001780 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 349741001781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741001782 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 349741001783 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 349741001784 trimer interface [polypeptide binding]; other site 349741001785 active site 349741001786 substrate binding site [chemical binding]; other site 349741001787 CoA binding site [chemical binding]; other site 349741001788 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741001789 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741001790 active site 349741001791 catalytic triad [active] 349741001792 oxyanion hole [active] 349741001793 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 349741001794 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 349741001795 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 349741001796 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 349741001797 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 349741001798 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 349741001799 Ligand Binding Site [chemical binding]; other site 349741001800 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 349741001801 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 349741001802 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 349741001803 G4 box; other site 349741001804 GTP/Mg2+ binding site [chemical binding]; other site 349741001805 G5 box; other site 349741001806 trmE is a tRNA modification GTPase; Region: trmE; cd04164 349741001807 G1 box; other site 349741001808 G1 box; other site 349741001809 GTP/Mg2+ binding site [chemical binding]; other site 349741001810 Switch I region; other site 349741001811 Switch I region; other site 349741001812 G2 box; other site 349741001813 G2 box; other site 349741001814 Switch II region; other site 349741001815 G3 box; other site 349741001816 G3 box; other site 349741001817 Switch II region; other site 349741001818 G4 box; other site 349741001819 G5 box; other site 349741001820 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 349741001821 Mac 1; Region: Mac-1; pfam09028 349741001822 Predicted membrane protein [Function unknown]; Region: COG2860 349741001823 UPF0126 domain; Region: UPF0126; pfam03458 349741001824 UPF0126 domain; Region: UPF0126; pfam03458 349741001825 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 349741001826 cell division protein MraZ; Reviewed; Region: PRK00326 349741001827 MraW methylase family; Region: Methyltransf_5; cl17771 349741001828 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 349741001829 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 349741001830 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 349741001831 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 349741001832 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 349741001833 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 349741001834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349741001835 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349741001836 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 349741001837 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 349741001838 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349741001839 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349741001840 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 349741001841 KorB domain; Region: KorB; pfam08535 349741001842 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 349741001843 Mg++ binding site [ion binding]; other site 349741001844 putative catalytic motif [active] 349741001845 putative substrate binding site [chemical binding]; other site 349741001846 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 349741001847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349741001848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349741001849 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349741001850 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 349741001851 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349741001852 cell division protein FtsW; Region: ftsW; TIGR02614 349741001853 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 349741001854 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 349741001855 active site 349741001856 homodimer interface [polypeptide binding]; other site 349741001857 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 349741001858 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 349741001859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349741001860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349741001861 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 349741001862 FAD binding domain; Region: FAD_binding_4; pfam01565 349741001863 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 349741001864 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 349741001865 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 349741001866 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349741001867 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 349741001868 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 349741001869 recombinase A; Provisional; Region: recA; PRK09354 349741001870 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 349741001871 hexamer interface [polypeptide binding]; other site 349741001872 Walker A motif; other site 349741001873 ATP binding site [chemical binding]; other site 349741001874 Walker B motif; other site 349741001875 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 349741001876 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 349741001877 active site 349741001878 metal binding site [ion binding]; metal-binding site 349741001879 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 349741001880 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 349741001881 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 349741001882 substrate binding site [chemical binding]; other site 349741001883 ligand binding site [chemical binding]; other site 349741001884 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 349741001885 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 349741001886 substrate binding site [chemical binding]; other site 349741001887 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 349741001888 Trypsin; Region: Trypsin; pfam00089 349741001889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741001890 protein binding site [polypeptide binding]; other site 349741001891 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349741001892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741001893 protein binding site [polypeptide binding]; other site 349741001894 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 349741001895 active site 349741001896 metal binding site [ion binding]; metal-binding site 349741001897 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 349741001898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 349741001899 Walker A/P-loop; other site 349741001900 ATP binding site [chemical binding]; other site 349741001901 Q-loop/lid; other site 349741001902 ABC transporter signature motif; other site 349741001903 Walker B; other site 349741001904 D-loop; other site 349741001905 H-loop/switch region; other site 349741001906 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 349741001907 elongation factor Ts; Provisional; Region: tsf; PRK09377 349741001908 UBA/TS-N domain; Region: UBA; pfam00627 349741001909 Elongation factor TS; Region: EF_TS; pfam00889 349741001910 Elongation factor TS; Region: EF_TS; pfam00889 349741001911 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 349741001912 rRNA interaction site [nucleotide binding]; other site 349741001913 S8 interaction site; other site 349741001914 putative laminin-1 binding site; other site 349741001915 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 349741001916 putative active site [active] 349741001917 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 349741001918 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 349741001919 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 349741001920 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 349741001921 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 349741001922 Walker A/P-loop; other site 349741001923 ATP binding site [chemical binding]; other site 349741001924 Q-loop/lid; other site 349741001925 ABC transporter signature motif; other site 349741001926 Walker B; other site 349741001927 D-loop; other site 349741001928 H-loop/switch region; other site 349741001929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 349741001930 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 349741001931 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 349741001932 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349741001933 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349741001934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 349741001935 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 349741001936 ligand binding site [chemical binding]; other site 349741001937 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 349741001938 Part of AAA domain; Region: AAA_19; pfam13245 349741001939 Family description; Region: UvrD_C_2; pfam13538 349741001940 Predicted transcriptional regulators [Transcription]; Region: COG1733 349741001941 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 349741001942 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 349741001943 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 349741001944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741001945 Walker A/P-loop; other site 349741001946 ATP binding site [chemical binding]; other site 349741001947 Q-loop/lid; other site 349741001948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741001949 ABC transporter signature motif; other site 349741001950 Walker B; other site 349741001951 D-loop; other site 349741001952 H-loop/switch region; other site 349741001953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741001954 Walker A/P-loop; other site 349741001955 ATP binding site [chemical binding]; other site 349741001956 Q-loop/lid; other site 349741001957 ABC transporter signature motif; other site 349741001958 Walker B; other site 349741001959 D-loop; other site 349741001960 H-loop/switch region; other site 349741001961 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 349741001962 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741001963 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 349741001964 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 349741001965 putative dimer interface [polypeptide binding]; other site 349741001966 putative anticodon binding site; other site 349741001967 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 349741001968 homodimer interface [polypeptide binding]; other site 349741001969 motif 1; other site 349741001970 motif 2; other site 349741001971 active site 349741001972 motif 3; other site 349741001973 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 349741001974 putative active site [active] 349741001975 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 349741001976 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741001977 catalytic residues [active] 349741001978 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741001979 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 349741001980 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741001981 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 349741001982 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741001983 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 349741001984 active site 349741001985 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 349741001986 active site 349741001987 Transcriptional regulator [Transcription]; Region: LysR; COG0583 349741001988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 349741001989 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 349741001990 putative dimerization interface [polypeptide binding]; other site 349741001991 Predicted membrane protein [Function unknown]; Region: COG2855 349741001992 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 349741001993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741001994 catalytic residue [active] 349741001995 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 349741001996 Uncharacterized conserved protein [Function unknown]; Region: COG4198 349741001997 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 349741001998 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 349741001999 putative ligand binding site [chemical binding]; other site 349741002000 putative NAD binding site [chemical binding]; other site 349741002001 putative catalytic site [active] 349741002002 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 349741002003 putative L-serine binding site [chemical binding]; other site 349741002004 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 349741002005 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 349741002006 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741002007 FeS/SAM binding site; other site 349741002008 transcription termination factor Rho; Provisional; Region: PRK12608 349741002009 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349741002010 RNA binding site [nucleotide binding]; other site 349741002011 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 349741002012 Walker A motif; other site 349741002013 ATP binding site [chemical binding]; other site 349741002014 Walker B motif; other site 349741002015 hypothetical protein; Validated; Region: PRK00110 349741002016 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 349741002017 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 349741002018 putative cation:proton antiport protein; Provisional; Region: PRK10669 349741002019 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 349741002020 TrkA-N domain; Region: TrkA_N; pfam02254 349741002021 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 349741002022 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 349741002023 hypothetical protein; Provisional; Region: PRK13665 349741002024 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 349741002025 ThiS interaction site; other site 349741002026 putative active site [active] 349741002027 tetramer interface [polypeptide binding]; other site 349741002028 Spore germination protein; Region: Spore_permease; cl17796 349741002029 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 349741002030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741002031 motif II; other site 349741002032 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 349741002033 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 349741002034 Domain of unknown function DUF20; Region: UPF0118; pfam01594 349741002035 diaminopimelate decarboxylase; Region: lysA; TIGR01048 349741002036 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 349741002037 active site 349741002038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349741002039 substrate binding site [chemical binding]; other site 349741002040 catalytic residues [active] 349741002041 dimer interface [polypeptide binding]; other site 349741002042 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 349741002043 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 349741002044 active site 349741002045 intersubunit interface [polypeptide binding]; other site 349741002046 zinc binding site [ion binding]; other site 349741002047 Na+ binding site [ion binding]; other site 349741002048 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 349741002049 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 349741002050 G1 box; other site 349741002051 putative GEF interaction site [polypeptide binding]; other site 349741002052 GTP/Mg2+ binding site [chemical binding]; other site 349741002053 Switch I region; other site 349741002054 G2 box; other site 349741002055 G3 box; other site 349741002056 Switch II region; other site 349741002057 G4 box; other site 349741002058 G5 box; other site 349741002059 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 349741002060 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 349741002061 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 349741002062 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 349741002063 homodimer interface [polypeptide binding]; other site 349741002064 substrate-cofactor binding pocket; other site 349741002065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741002066 catalytic residue [active] 349741002067 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 349741002068 active site 349741002069 catalytic residues [active] 349741002070 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 349741002071 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 349741002072 DNA binding site [nucleotide binding] 349741002073 active site 349741002074 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 349741002075 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 349741002076 phosphopeptide binding site; other site 349741002077 GTPase CgtA; Reviewed; Region: obgE; PRK12299 349741002078 GTP1/OBG; Region: GTP1_OBG; pfam01018 349741002079 Obg GTPase; Region: Obg; cd01898 349741002080 G1 box; other site 349741002081 GTP/Mg2+ binding site [chemical binding]; other site 349741002082 Switch I region; other site 349741002083 G2 box; other site 349741002084 G3 box; other site 349741002085 Switch II region; other site 349741002086 G4 box; other site 349741002087 G5 box; other site 349741002088 Phosphotransferase enzyme family; Region: APH; pfam01636 349741002089 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349741002090 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741002091 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741002092 RHS Repeat; Region: RHS_repeat; pfam05593 349741002093 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741002094 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741002095 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 349741002096 Low molecular weight phosphatase family; Region: LMWPc; cd00115 349741002097 active site 349741002098 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 349741002099 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 349741002100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 349741002101 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 349741002102 active site 349741002103 GMP synthase; Reviewed; Region: guaA; PRK00074 349741002104 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 349741002105 AMP/PPi binding site [chemical binding]; other site 349741002106 candidate oxyanion hole; other site 349741002107 catalytic triad [active] 349741002108 potential glutamine specificity residues [chemical binding]; other site 349741002109 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 349741002110 ATP Binding subdomain [chemical binding]; other site 349741002111 Ligand Binding sites [chemical binding]; other site 349741002112 Dimerization subdomain; other site 349741002113 maltose O-acetyltransferase; Provisional; Region: PRK10092 349741002114 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 349741002115 active site 349741002116 substrate binding site [chemical binding]; other site 349741002117 trimer interface [polypeptide binding]; other site 349741002118 CoA binding site [chemical binding]; other site 349741002119 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 349741002120 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741002121 motif II; other site 349741002122 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 349741002123 putative metal binding site [ion binding]; other site 349741002124 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 349741002125 Membrane transport protein; Region: Mem_trans; cl09117 349741002126 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 349741002127 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 349741002128 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 349741002129 Preprotein translocase SecG subunit; Region: SecG; pfam03840 349741002130 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 349741002131 tetramerization interface [polypeptide binding]; other site 349741002132 active site 349741002133 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 349741002134 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 349741002135 active site 349741002136 Riboflavin kinase; Region: Flavokinase; smart00904 349741002137 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 349741002138 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 349741002139 RNA binding site [nucleotide binding]; other site 349741002140 active site 349741002141 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 349741002142 DHH family; Region: DHH; pfam01368 349741002143 DHHA1 domain; Region: DHHA1; pfam02272 349741002144 phosphodiesterase YaeI; Provisional; Region: PRK11340 349741002145 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 349741002146 putative active site [active] 349741002147 putative metal binding site [ion binding]; other site 349741002148 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 349741002149 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 349741002150 Ligand binding site; other site 349741002151 metal-binding site 349741002152 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349741002153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741002154 active site 349741002155 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 349741002156 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 349741002157 putative active site [active] 349741002158 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 349741002159 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 349741002160 NADP binding site [chemical binding]; other site 349741002161 homopentamer interface [polypeptide binding]; other site 349741002162 substrate binding site [chemical binding]; other site 349741002163 active site 349741002164 putative glycosyl transferase; Provisional; Region: PRK10073 349741002165 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741002166 active site 349741002167 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741002168 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741002169 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 349741002170 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 349741002171 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 349741002172 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 349741002173 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 349741002174 transmembrane helices; other site 349741002175 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 349741002176 TrkA-C domain; Region: TrkA_C; pfam02080 349741002177 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 349741002178 TrkA-C domain; Region: TrkA_C; pfam02080 349741002179 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 349741002180 Bifunctional nuclease; Region: DNase-RNase; cl00553 349741002181 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 349741002182 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 349741002183 trimer interface [polypeptide binding]; other site 349741002184 putative metal binding site [ion binding]; other site 349741002185 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 349741002186 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 349741002187 putative FMN binding site [chemical binding]; other site 349741002188 NADPH bind site [chemical binding]; other site 349741002189 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 349741002190 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 349741002191 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349741002192 catalytic core [active] 349741002193 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 349741002194 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 349741002195 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 349741002196 putative ligand binding site [chemical binding]; other site 349741002197 putative NAD binding site [chemical binding]; other site 349741002198 catalytic site [active] 349741002199 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 349741002200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741002201 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349741002202 putative substrate translocation pore; other site 349741002203 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 349741002204 oxidoreductase; Provisional; Region: PRK07985 349741002205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741002206 NAD(P) binding site [chemical binding]; other site 349741002207 active site 349741002208 Alginate lyase; Region: Alginate_lyase; pfam05426 349741002209 Staphylococcal nuclease homologues; Region: SNc; smart00318 349741002210 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 349741002211 Catalytic site; other site 349741002212 Uncharacterized conserved protein [Function unknown]; Region: COG0585 349741002213 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 349741002214 ParB-like nuclease domain; Region: ParBc; pfam02195 349741002215 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 349741002216 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 349741002217 Active Sites [active] 349741002218 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 349741002219 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 349741002220 tartrate dehydrogenase; Region: TTC; TIGR02089 349741002221 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 349741002222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349741002223 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 349741002224 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 349741002225 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 349741002226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741002227 Walker A motif; other site 349741002228 ATP binding site [chemical binding]; other site 349741002229 Walker B motif; other site 349741002230 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 349741002231 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 349741002232 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 349741002233 homodimer interface [polypeptide binding]; other site 349741002234 substrate-cofactor binding pocket; other site 349741002235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741002236 catalytic residue [active] 349741002237 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 349741002238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741002239 FeS/SAM binding site; other site 349741002240 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 349741002241 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 349741002242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741002243 FeS/SAM binding site; other site 349741002244 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 349741002245 putative exosortase-associated protein, TIGR04073 family; Region: exo_TIGR04073 349741002246 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 349741002247 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 349741002248 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 349741002249 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 349741002250 active site 349741002251 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 349741002252 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 349741002253 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 349741002254 dimer interface [polypeptide binding]; other site 349741002255 putative anticodon binding site; other site 349741002256 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 349741002257 motif 1; other site 349741002258 dimer interface [polypeptide binding]; other site 349741002259 active site 349741002260 motif 2; other site 349741002261 motif 3; other site 349741002262 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 349741002263 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 349741002264 dimer interface [polypeptide binding]; other site 349741002265 PYR/PP interface [polypeptide binding]; other site 349741002266 TPP binding site [chemical binding]; other site 349741002267 substrate binding site [chemical binding]; other site 349741002268 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 349741002269 Domain of unknown function; Region: EKR; pfam10371 349741002270 4Fe-4S binding domain; Region: Fer4_6; pfam12837 349741002271 4Fe-4S binding domain; Region: Fer4_6; pfam12837 349741002272 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 349741002273 TPP-binding site [chemical binding]; other site 349741002274 dimer interface [polypeptide binding]; other site 349741002275 Cupin domain; Region: Cupin_2; cl17218 349741002276 Predicted transcriptional regulators [Transcription]; Region: COG1733 349741002277 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 349741002278 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741002279 sugar binding site [chemical binding]; other site 349741002280 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 349741002281 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 349741002282 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 349741002283 substrate binding site [chemical binding]; other site 349741002284 glutamase interaction surface [polypeptide binding]; other site 349741002285 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 349741002286 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 349741002287 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 349741002288 TrkA-N domain; Region: TrkA_N; pfam02254 349741002289 TrkA-C domain; Region: TrkA_C; pfam02080 349741002290 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 349741002291 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741002292 ATP binding site [chemical binding]; other site 349741002293 putative Mg++ binding site [ion binding]; other site 349741002294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741002295 nucleotide binding region [chemical binding]; other site 349741002296 ATP-binding site [chemical binding]; other site 349741002297 Helicase associated domain (HA2); Region: HA2; pfam04408 349741002298 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 349741002299 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 349741002300 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 349741002301 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 349741002302 putative valine binding site [chemical binding]; other site 349741002303 dimer interface [polypeptide binding]; other site 349741002304 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 349741002305 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 349741002306 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349741002307 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741002308 protein binding site [polypeptide binding]; other site 349741002309 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741002310 protein binding site [polypeptide binding]; other site 349741002311 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 349741002312 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 349741002313 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 349741002314 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 349741002315 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 349741002316 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 349741002317 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 349741002318 catalytic motif [active] 349741002319 Zn binding site [ion binding]; other site 349741002320 RibD C-terminal domain; Region: RibD_C; cl17279 349741002321 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 349741002322 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 349741002323 DNA polymerase III subunit beta; Provisional; Region: PRK14943 349741002324 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 349741002325 putative DNA binding surface [nucleotide binding]; other site 349741002326 dimer interface [polypeptide binding]; other site 349741002327 beta-clamp/clamp loader binding surface; other site 349741002328 beta-clamp/translesion DNA polymerase binding surface; other site 349741002329 S-adenosylhomocysteine hydrolase [Coenzyme metabolism]; Region: SAM1; COG0499 349741002330 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 349741002331 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 349741002332 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 349741002333 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741002334 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 349741002335 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 349741002336 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 349741002337 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 349741002338 active site 349741002339 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 349741002340 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 349741002341 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 349741002342 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 349741002343 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349741002344 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 349741002345 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 349741002346 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cd00057 349741002347 sugar binding site [chemical binding]; other site 349741002348 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 349741002349 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 349741002350 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 349741002351 Ligand Binding Site [chemical binding]; other site 349741002352 GAF domain; Region: GAF_3; pfam13492 349741002353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349741002354 dimer interface [polypeptide binding]; other site 349741002355 phosphorylation site [posttranslational modification] 349741002356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741002357 ATP binding site [chemical binding]; other site 349741002358 Mg2+ binding site [ion binding]; other site 349741002359 G-X-G motif; other site 349741002360 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349741002361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349741002362 active site 349741002363 phosphorylation site [posttranslational modification] 349741002364 intermolecular recognition site; other site 349741002365 dimerization interface [polypeptide binding]; other site 349741002366 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349741002367 DNA binding site [nucleotide binding] 349741002368 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 349741002369 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 349741002370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741002371 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349741002372 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 349741002373 Cupin domain; Region: Cupin_2; pfam07883 349741002374 Transcriptional regulators [Transcription]; Region: MarR; COG1846 349741002375 MarR family; Region: MarR_2; pfam12802 349741002376 MarR family; Region: MarR_2; cl17246 349741002377 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 349741002378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741002379 Coenzyme A binding pocket [chemical binding]; other site 349741002380 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 349741002381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741002382 Walker A motif; other site 349741002383 ATP binding site [chemical binding]; other site 349741002384 Walker B motif; other site 349741002385 arginine finger; other site 349741002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741002387 Walker A motif; other site 349741002388 ATP binding site [chemical binding]; other site 349741002389 Walker B motif; other site 349741002390 arginine finger; other site 349741002391 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 349741002392 Domain of unknown function (DUF303); Region: DUF303; pfam03629 349741002393 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 349741002394 ATP cone domain; Region: ATP-cone; pfam03477 349741002395 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 349741002396 putative transporter; Provisional; Region: PRK11660 349741002397 Sulfate transporter family; Region: Sulfate_transp; pfam00916 349741002398 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 349741002399 argininosuccinate lyase; Provisional; Region: PRK00855 349741002400 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 349741002401 active sites [active] 349741002402 tetramer interface [polypeptide binding]; other site 349741002403 Uncharacterized conserved protein [Function unknown]; Region: COG4279 349741002404 SWIM zinc finger; Region: SWIM; pfam04434 349741002405 enolase; Provisional; Region: eno; PRK00077 349741002406 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 349741002407 dimer interface [polypeptide binding]; other site 349741002408 metal binding site [ion binding]; metal-binding site 349741002409 substrate binding pocket [chemical binding]; other site 349741002410 endonuclease IV; Provisional; Region: PRK01060 349741002411 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 349741002412 AP (apurinic/apyrimidinic) site pocket; other site 349741002413 DNA interaction; other site 349741002414 Metal-binding active site; metal-binding site 349741002415 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 349741002416 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 349741002417 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741002418 Fn3 associated; Region: Fn3_assoc; pfam13287 349741002419 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741002420 sugar binding site [chemical binding]; other site 349741002421 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 349741002422 generic binding surface I; other site 349741002423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349741002424 Zn2+ binding site [ion binding]; other site 349741002425 Mg2+ binding site [ion binding]; other site 349741002426 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 349741002427 Competence protein; Region: Competence; pfam03772 349741002428 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 349741002429 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 349741002430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741002431 FeS/SAM binding site; other site 349741002432 TRAM domain; Region: TRAM; pfam01938 349741002433 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 349741002434 TRAM domain; Region: TRAM; pfam01938 349741002435 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 349741002436 IHF - DNA interface [nucleotide binding]; other site 349741002437 IHF dimer interface [polypeptide binding]; other site 349741002438 Melibiase; Region: Melibiase; pfam02065 349741002439 Predicted permease [General function prediction only]; Region: COG2985 349741002440 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 349741002441 TrkA-C domain; Region: TrkA_C; pfam02080 349741002442 TrkA-C domain; Region: TrkA_C; pfam02080 349741002443 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 349741002444 Response regulator receiver domain; Region: Response_reg; pfam00072 349741002445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349741002446 active site 349741002447 phosphorylation site [posttranslational modification] 349741002448 intermolecular recognition site; other site 349741002449 dimerization interface [polypeptide binding]; other site 349741002450 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 349741002451 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 349741002452 ligand binding site [chemical binding]; other site 349741002453 flexible hinge region; other site 349741002454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 349741002455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741002456 ATP binding site [chemical binding]; other site 349741002457 Mg2+ binding site [ion binding]; other site 349741002458 G-X-G motif; other site 349741002459 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 349741002460 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 349741002461 transmembrane helices; other site 349741002462 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 349741002463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741002464 FeS/SAM binding site; other site 349741002465 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 349741002466 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 349741002467 ATP cone domain; Region: ATP-cone; pfam03477 349741002468 Class III ribonucleotide reductase; Region: RNR_III; cd01675 349741002469 effector binding site; other site 349741002470 active site 349741002471 Zn binding site [ion binding]; other site 349741002472 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 349741002473 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 349741002474 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 349741002475 Sulfatase; Region: Sulfatase; cl17466 349741002476 Rubrerythrin [Energy production and conversion]; Region: COG1592 349741002477 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 349741002478 binuclear metal center [ion binding]; other site 349741002479 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 349741002480 iron binding site [ion binding]; other site 349741002481 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 349741002482 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 349741002483 oligomer interface [polypeptide binding]; other site 349741002484 active site 349741002485 metal binding site [ion binding]; metal-binding site 349741002486 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 349741002487 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741002488 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741002489 active site 349741002490 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 349741002491 Alkaline phosphatase homologues; Region: alkPPc; smart00098 349741002492 active site 349741002493 dimer interface [polypeptide binding]; other site 349741002494 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 349741002495 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 349741002496 acetylornithine aminotransferase; Provisional; Region: PRK02627 349741002497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 349741002498 inhibitor-cofactor binding pocket; inhibition site 349741002499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741002500 catalytic residue [active] 349741002501 ACT domain-containing protein [General function prediction only]; Region: COG4747 349741002502 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 349741002503 elongation factor P; Validated; Region: PRK00529 349741002504 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 349741002505 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 349741002506 RNA binding site [nucleotide binding]; other site 349741002507 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 349741002508 RNA binding site [nucleotide binding]; other site 349741002509 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 349741002510 active site 349741002511 catalytic residues [active] 349741002512 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 349741002513 Heavy-metal-associated domain; Region: HMA; pfam00403 349741002514 metal-binding site [ion binding] 349741002515 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741002516 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349741002517 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 349741002518 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 349741002519 Walker A/P-loop; other site 349741002520 ATP binding site [chemical binding]; other site 349741002521 Q-loop/lid; other site 349741002522 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 349741002523 ABC transporter signature motif; other site 349741002524 Walker B; other site 349741002525 D-loop; other site 349741002526 H-loop/switch region; other site 349741002527 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 349741002528 putative hydrolase; Provisional; Region: PRK02113 349741002529 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 349741002530 Protein of unknown function (DUF419); Region: DUF419; cl15265 349741002531 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920 349741002532 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 349741002533 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 349741002534 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 349741002535 E3 interaction surface; other site 349741002536 lipoyl attachment site [posttranslational modification]; other site 349741002537 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 349741002538 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 349741002539 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 349741002540 alpha subunit interface [polypeptide binding]; other site 349741002541 TPP binding site [chemical binding]; other site 349741002542 heterodimer interface [polypeptide binding]; other site 349741002543 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 349741002544 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 349741002545 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 349741002546 tetramer interface [polypeptide binding]; other site 349741002547 TPP-binding site [chemical binding]; other site 349741002548 heterodimer interface [polypeptide binding]; other site 349741002549 phosphorylation loop region [posttranslational modification] 349741002550 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 349741002551 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 349741002552 DNA binding residues [nucleotide binding] 349741002553 drug binding residues [chemical binding]; other site 349741002554 dimer interface [polypeptide binding]; other site 349741002555 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 349741002556 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 349741002557 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741002558 multidrug efflux protein; Reviewed; Region: PRK09577 349741002559 Protein export membrane protein; Region: SecD_SecF; cl14618 349741002560 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741002561 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 349741002562 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 349741002563 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 349741002564 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 349741002565 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 349741002566 active site 349741002567 SAM binding site [chemical binding]; other site 349741002568 homodimer interface [polypeptide binding]; other site 349741002569 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 349741002570 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 349741002571 active site 349741002572 DNA topoisomerase III; Validated; Region: PRK08173 349741002573 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 349741002574 active site 349741002575 putative interdomain interaction site [polypeptide binding]; other site 349741002576 putative metal-binding site [ion binding]; other site 349741002577 putative nucleotide binding site [chemical binding]; other site 349741002578 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 349741002579 domain I; other site 349741002580 DNA binding groove [nucleotide binding] 349741002581 phosphate binding site [ion binding]; other site 349741002582 domain II; other site 349741002583 domain III; other site 349741002584 nucleotide binding site [chemical binding]; other site 349741002585 catalytic site [active] 349741002586 domain IV; other site 349741002587 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 349741002588 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 349741002589 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 349741002590 amidase catalytic site [active] 349741002591 Zn binding residues [ion binding]; other site 349741002592 substrate binding site [chemical binding]; other site 349741002593 aconitate hydratase; Validated; Region: PRK09277 349741002594 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 349741002595 substrate binding site [chemical binding]; other site 349741002596 ligand binding site [chemical binding]; other site 349741002597 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 349741002598 substrate binding site [chemical binding]; other site 349741002599 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741002600 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 349741002601 methionine sulfoxide reductase B; Provisional; Region: PRK00222 349741002602 SelR domain; Region: SelR; pfam01641 349741002603 Peptidase M60-like family; Region: M60-like; pfam13402 349741002604 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 349741002605 hypothetical protein; Reviewed; Region: PRK09588 349741002606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 349741002607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 349741002608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 349741002609 dimerization interface [polypeptide binding]; other site 349741002610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741002611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349741002612 putative substrate translocation pore; other site 349741002613 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 349741002614 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 349741002615 ribonuclease R; Region: RNase_R; TIGR02063 349741002616 RNB domain; Region: RNB; pfam00773 349741002617 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 349741002618 Peptidase family U32; Region: Peptidase_U32; pfam01136 349741002619 Collagenase; Region: DUF3656; pfam12392 349741002620 Peptidase family U32; Region: Peptidase_U32; cl03113 349741002621 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 349741002622 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 349741002623 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 349741002624 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 349741002625 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 349741002626 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349741002627 SNF2 Helicase protein; Region: DUF3670; pfam12419 349741002628 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 349741002629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741002630 ATP binding site [chemical binding]; other site 349741002631 putative Mg++ binding site [ion binding]; other site 349741002632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741002633 nucleotide binding region [chemical binding]; other site 349741002634 ATP-binding site [chemical binding]; other site 349741002635 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 349741002636 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 349741002637 active site 349741002638 metal binding site [ion binding]; metal-binding site 349741002639 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 349741002640 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 349741002641 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 349741002642 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 349741002643 ATP-NAD kinase; Region: NAD_kinase; pfam01513 349741002644 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 349741002645 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 349741002646 RNA binding site [nucleotide binding]; other site 349741002647 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 349741002648 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 349741002649 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 349741002650 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 349741002651 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 349741002652 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 349741002653 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 349741002654 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 349741002655 5S rRNA interface [nucleotide binding]; other site 349741002656 L27 interface [polypeptide binding]; other site 349741002657 23S rRNA interface [nucleotide binding]; other site 349741002658 L5 interface [polypeptide binding]; other site 349741002659 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 349741002660 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 349741002661 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 349741002662 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 349741002663 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 349741002664 SecY translocase; Region: SecY; pfam00344 349741002665 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 349741002666 adenylate kinase; Reviewed; Region: adk; PRK00279 349741002667 AMP-binding site [chemical binding]; other site 349741002668 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 349741002669 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 349741002670 active site 349741002671 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 349741002672 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 349741002673 polyphosphate kinase; Provisional; Region: PRK05443 349741002674 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 349741002675 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 349741002676 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 349741002677 putative domain interface [polypeptide binding]; other site 349741002678 putative active site [active] 349741002679 catalytic site [active] 349741002680 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 349741002681 putative domain interface [polypeptide binding]; other site 349741002682 putative active site [active] 349741002683 catalytic site [active] 349741002684 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 349741002685 Ligand binding site; other site 349741002686 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 349741002687 metal-binding site 349741002688 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 349741002689 active site 349741002690 catalytic triad [active] 349741002691 oxyanion hole [active] 349741002692 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349741002693 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741002694 active site 349741002695 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 349741002696 GDP-Fucose binding site [chemical binding]; other site 349741002697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741002698 active site 349741002699 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741002700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741002701 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741002702 active site 349741002703 DJ-1 family protein; Region: not_thiJ; TIGR01383 349741002704 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 349741002705 conserved cys residue [active] 349741002706 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 349741002707 E3 interaction surface; other site 349741002708 lipoyl attachment site [posttranslational modification]; other site 349741002709 e3 binding domain; Region: E3_binding; pfam02817 349741002710 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 349741002711 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 349741002712 active site 349741002713 dimer interface [polypeptide binding]; other site 349741002714 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 349741002715 active site 349741002716 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 349741002717 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 349741002718 Carbon starvation protein CstA; Region: CstA; pfam02554 349741002719 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 349741002720 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741002721 Sulfatase; Region: Sulfatase; pfam00884 349741002722 PA14 domain; Region: PA14; cl08459 349741002723 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 349741002724 Ribosome-binding factor A; Region: RBFA; cl00542 349741002725 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 349741002726 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 349741002727 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 349741002728 G1 box; other site 349741002729 putative GEF interaction site [polypeptide binding]; other site 349741002730 GTP/Mg2+ binding site [chemical binding]; other site 349741002731 Switch I region; other site 349741002732 G2 box; other site 349741002733 G3 box; other site 349741002734 Switch II region; other site 349741002735 G4 box; other site 349741002736 G5 box; other site 349741002737 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 349741002738 Translation-initiation factor 2; Region: IF-2; pfam11987 349741002739 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 349741002740 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 349741002741 NusA N-terminal domain; Region: NusA_N; pfam08529 349741002742 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 349741002743 RNA binding site [nucleotide binding]; other site 349741002744 homodimer interface [polypeptide binding]; other site 349741002745 NusA-like KH domain; Region: KH_5; pfam13184 349741002746 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 349741002747 G-X-X-G motif; other site 349741002748 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 349741002749 active site 349741002750 putative catalytic site [active] 349741002751 DNA binding site [nucleotide binding] 349741002752 putative phosphate binding site [ion binding]; other site 349741002753 metal binding site A [ion binding]; metal-binding site 349741002754 AP binding site [nucleotide binding]; other site 349741002755 metal binding site B [ion binding]; metal-binding site 349741002756 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 349741002757 active site 349741002758 dimerization interface [polypeptide binding]; other site 349741002759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 349741002760 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 349741002761 Uncharacterized conserved protein [Function unknown]; Region: COG2006 349741002762 Domain of unknown function (DUF362); Region: DUF362; pfam04015 349741002763 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 349741002764 4Fe-4S binding domain; Region: Fer4_5; pfam12801 349741002765 4Fe-4S binding domain; Region: Fer4_5; pfam12801 349741002766 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 349741002767 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 349741002768 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 349741002769 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 349741002770 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 349741002771 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 349741002772 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 349741002773 Walker A/P-loop; other site 349741002774 ATP binding site [chemical binding]; other site 349741002775 Q-loop/lid; other site 349741002776 ABC transporter signature motif; other site 349741002777 Walker B; other site 349741002778 D-loop; other site 349741002779 H-loop/switch region; other site 349741002780 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 349741002781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 349741002782 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 349741002783 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 349741002784 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 349741002785 Bacterial sugar transferase; Region: Bac_transf; pfam02397 349741002786 galactokinase; Provisional; Region: PRK05101 349741002787 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 349741002788 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 349741002789 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 349741002790 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 349741002791 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 349741002792 Na binding site [ion binding]; other site 349741002793 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 349741002794 Part of AAA domain; Region: AAA_19; pfam13245 349741002795 Family description; Region: UvrD_C_2; pfam13538 349741002796 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 349741002797 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 349741002798 putative active site [active] 349741002799 substrate binding site [chemical binding]; other site 349741002800 putative cosubstrate binding site; other site 349741002801 catalytic site [active] 349741002802 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 349741002803 substrate binding site [chemical binding]; other site 349741002804 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 349741002805 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 349741002806 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741002807 Type III pantothenate kinase; Region: Pan_kinase; cl17198 349741002808 acyl carrier protein; Provisional; Region: acpP; PRK00982 349741002809 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 349741002810 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 349741002811 putative active site [active] 349741002812 dimerization interface [polypeptide binding]; other site 349741002813 putative tRNAtyr binding site [nucleotide binding]; other site 349741002814 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741002815 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 349741002816 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741002817 RHS Repeat; Region: RHS_repeat; pfam05593 349741002818 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741002819 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741002820 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 349741002821 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 349741002822 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 349741002823 L-aspartate oxidase; Provisional; Region: PRK06175 349741002824 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 349741002825 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 349741002826 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 349741002827 putative Iron-sulfur protein interface [polypeptide binding]; other site 349741002828 proximal heme binding site [chemical binding]; other site 349741002829 distal heme binding site [chemical binding]; other site 349741002830 putative dimer interface [polypeptide binding]; other site 349741002831 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 349741002832 active site 349741002833 TatD related DNase; Region: TatD_DNase; pfam01026 349741002834 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 349741002835 Uncharacterized conserved protein [Function unknown]; Region: COG1262 349741002836 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 349741002837 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 349741002838 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 349741002839 NAD(P) binding site [chemical binding]; other site 349741002840 homotetramer interface [polypeptide binding]; other site 349741002841 homodimer interface [polypeptide binding]; other site 349741002842 active site 349741002843 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 349741002844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349741002845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349741002846 ABC transporter; Region: ABC_tran_2; pfam12848 349741002847 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349741002848 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 349741002849 30S subunit binding site; other site 349741002850 short chain dehydrogenase; Provisional; Region: PRK06940 349741002851 classical (c) SDRs; Region: SDR_c; cd05233 349741002852 NAD(P) binding site [chemical binding]; other site 349741002853 active site 349741002854 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 349741002855 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 349741002856 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 349741002857 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 349741002858 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741002859 active site 349741002860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741002861 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741002862 catalytic tetrad [active] 349741002863 Helix-turn-helix domain; Region: HTH_18; pfam12833 349741002864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 349741002865 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 349741002866 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 349741002867 CPE1046 is an uncharacterized Clostridium perfringens protein with a glycosyl hydrolase family 31 (GH31) domain. The domain architecture of CPE1046 and its orthologs includes a C-terminal fibronectin type 3 (FN3) domain and a coagulation factor 5/8 type...; Region: GH31_CPE1046; cd06596 349741002868 putative active site [active] 349741002869 putative catalytic site [active] 349741002870 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 349741002871 Interdomain contacts; other site 349741002872 Cytokine receptor motif; other site 349741002873 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741002874 EF-hand domain pair; Region: EF_hand_5; pfam13499 349741002875 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 349741002876 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 349741002877 LytTr DNA-binding domain; Region: LytTR; smart00850 349741002878 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 349741002879 Protein of unknown function (DUF2589); Region: DUF2589; pfam11655 349741002880 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 349741002881 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 349741002882 MarC family integral membrane protein; Region: MarC; cl00919 349741002883 PA14 domain; Region: PA14; cl08459 349741002884 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741002885 active site 349741002886 catalytic triad [active] 349741002887 oxyanion hole [active] 349741002888 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cl00236 349741002889 dimerization interface [polypeptide binding]; other site 349741002890 domain crossover interface; other site 349741002891 redox-dependent activation switch; other site 349741002892 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 349741002893 active site 349741002894 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 349741002895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741002896 Walker A/P-loop; other site 349741002897 ATP binding site [chemical binding]; other site 349741002898 Q-loop/lid; other site 349741002899 ABC transporter signature motif; other site 349741002900 Walker B; other site 349741002901 D-loop; other site 349741002902 H-loop/switch region; other site 349741002903 ABC transporter; Region: ABC_tran_2; pfam12848 349741002904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 349741002905 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 349741002906 EamA-like transporter family; Region: EamA; pfam00892 349741002907 EamA-like transporter family; Region: EamA; pfam00892 349741002908 Cupin domain; Region: Cupin_2; pfam07883 349741002909 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 349741002910 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741002911 active site 349741002912 HIGH motif; other site 349741002913 nucleotide binding site [chemical binding]; other site 349741002914 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 349741002915 KMSKS motif; other site 349741002916 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 349741002917 tRNA binding surface [nucleotide binding]; other site 349741002918 anticodon binding site; other site 349741002919 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741002920 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741002921 active site 349741002922 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741002923 Sulfatase; Region: Sulfatase; cl17466 349741002924 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741002925 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 349741002926 GTP-binding protein LepA; Provisional; Region: PRK05433 349741002927 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 349741002928 G1 box; other site 349741002929 putative GEF interaction site [polypeptide binding]; other site 349741002930 GTP/Mg2+ binding site [chemical binding]; other site 349741002931 Switch I region; other site 349741002932 G2 box; other site 349741002933 G3 box; other site 349741002934 Switch II region; other site 349741002935 G4 box; other site 349741002936 G5 box; other site 349741002937 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 349741002938 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 349741002939 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 349741002940 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741002941 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 349741002942 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 349741002943 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 349741002944 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 349741002945 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 349741002946 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 349741002947 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 349741002948 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 349741002949 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 349741002950 DNA binding site [nucleotide binding] 349741002951 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 349741002952 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 349741002953 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 349741002954 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 349741002955 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 349741002956 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 349741002957 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 349741002958 RPB3 interaction site [polypeptide binding]; other site 349741002959 RPB1 interaction site [polypeptide binding]; other site 349741002960 RPB11 interaction site [polypeptide binding]; other site 349741002961 RPB10 interaction site [polypeptide binding]; other site 349741002962 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 349741002963 core dimer interface [polypeptide binding]; other site 349741002964 peripheral dimer interface [polypeptide binding]; other site 349741002965 L10 interface [polypeptide binding]; other site 349741002966 L11 interface [polypeptide binding]; other site 349741002967 putative EF-Tu interaction site [polypeptide binding]; other site 349741002968 putative EF-G interaction site [polypeptide binding]; other site 349741002969 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 349741002970 23S rRNA interface [nucleotide binding]; other site 349741002971 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 349741002972 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 349741002973 mRNA/rRNA interface [nucleotide binding]; other site 349741002974 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 349741002975 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 349741002976 23S rRNA interface [nucleotide binding]; other site 349741002977 L7/L12 interface [polypeptide binding]; other site 349741002978 putative thiostrepton binding site; other site 349741002979 L25 interface [polypeptide binding]; other site 349741002980 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 349741002981 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 349741002982 putative homodimer interface [polypeptide binding]; other site 349741002983 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 349741002984 heterodimer interface [polypeptide binding]; other site 349741002985 homodimer interface [polypeptide binding]; other site 349741002986 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 349741002987 elongation factor Tu; Reviewed; Region: PRK00049 349741002988 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 349741002989 G1 box; other site 349741002990 GEF interaction site [polypeptide binding]; other site 349741002991 GTP/Mg2+ binding site [chemical binding]; other site 349741002992 Switch I region; other site 349741002993 G2 box; other site 349741002994 G3 box; other site 349741002995 Switch II region; other site 349741002996 G4 box; other site 349741002997 G5 box; other site 349741002998 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 349741002999 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 349741003000 Antibiotic Binding Site [chemical binding]; other site 349741003001 UGMP family protein; Validated; Region: PRK09604 349741003002 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 349741003003 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 349741003004 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 349741003005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741003006 Walker A motif; other site 349741003007 ATP binding site [chemical binding]; other site 349741003008 Walker B motif; other site 349741003009 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 349741003010 Clp protease; Region: CLP_protease; pfam00574 349741003011 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 349741003012 oligomer interface [polypeptide binding]; other site 349741003013 active site residues [active] 349741003014 trigger factor; Provisional; Region: tig; PRK01490 349741003015 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 349741003016 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 349741003017 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 349741003018 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 349741003019 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 349741003020 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 349741003021 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 349741003022 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 349741003023 Surface antigen; Region: Bac_surface_Ag; pfam01103 349741003024 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 349741003025 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 349741003026 FAD binding site [chemical binding]; other site 349741003027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 349741003028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 349741003029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 349741003030 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 349741003031 Protein export membrane protein; Region: SecD_SecF; cl14618 349741003032 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 349741003033 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741003034 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 349741003035 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 349741003036 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 349741003037 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 349741003038 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 349741003039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741003040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349741003041 putative substrate translocation pore; other site 349741003042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 349741003043 dimerization interface [polypeptide binding]; other site 349741003044 putative DNA binding site [nucleotide binding]; other site 349741003045 putative Zn2+ binding site [ion binding]; other site 349741003046 Methyltransferase domain; Region: Methyltransf_31; pfam13847 349741003047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741003048 S-adenosylmethionine binding site [chemical binding]; other site 349741003049 S-adenosylmethionine synthetase; Validated; Region: PRK05250 349741003050 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 349741003051 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 349741003052 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 349741003053 Adenosylhomocysteinase; Provisional; Region: PTZ00075 349741003054 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 349741003055 homotetramer interface [polypeptide binding]; other site 349741003056 ligand binding site [chemical binding]; other site 349741003057 catalytic site [active] 349741003058 NAD binding site [chemical binding]; other site 349741003059 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349741003060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 349741003061 active site 349741003062 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 349741003063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 349741003064 Sulfatase; Region: Sulfatase; cl17466 349741003065 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741003066 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 349741003067 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741003068 ATP binding site [chemical binding]; other site 349741003069 putative Mg++ binding site [ion binding]; other site 349741003070 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741003071 nucleotide binding region [chemical binding]; other site 349741003072 ATP-binding site [chemical binding]; other site 349741003073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741003074 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741003075 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 349741003076 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741003077 L-aspartate oxidase; Provisional; Region: PRK09077 349741003078 L-aspartate oxidase; Provisional; Region: PRK06175 349741003079 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 349741003080 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 349741003081 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 349741003082 active site 349741003083 metal binding site [ion binding]; metal-binding site 349741003084 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 349741003085 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 349741003086 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 349741003087 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 349741003088 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741003089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741003090 motif II; other site 349741003091 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 349741003092 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 349741003093 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 349741003094 G1 box; other site 349741003095 GTP/Mg2+ binding site [chemical binding]; other site 349741003096 Switch I region; other site 349741003097 G2 box; other site 349741003098 G3 box; other site 349741003099 Switch II region; other site 349741003100 G4 box; other site 349741003101 G5 box; other site 349741003102 Nucleoside recognition; Region: Gate; pfam07670 349741003103 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 349741003104 Nucleoside recognition; Region: Gate; pfam07670 349741003105 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 349741003106 FeoA domain; Region: FeoA; pfam04023 349741003107 Haem-binding domain; Region: Haem_bd; pfam14376 349741003108 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 349741003109 lipoyl synthase; Provisional; Region: PRK05481 349741003110 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741003111 FeS/SAM binding site; other site 349741003112 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 349741003113 nucleoside/Zn binding site; other site 349741003114 dimer interface [polypeptide binding]; other site 349741003115 catalytic motif [active] 349741003116 D-allose kinase; Provisional; Region: PRK09698 349741003117 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 349741003118 nucleotide binding site [chemical binding]; other site 349741003119 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 349741003120 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741003121 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349741003122 transcription termination factor Rho; Provisional; Region: rho; PRK09376 349741003123 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 349741003124 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349741003125 RNA binding site [nucleotide binding]; other site 349741003126 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 349741003127 Walker A motif; other site 349741003128 ATP binding site [chemical binding]; other site 349741003129 Walker B motif; other site 349741003130 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 349741003131 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 349741003132 CoA-binding site [chemical binding]; other site 349741003133 ATP-binding [chemical binding]; other site 349741003134 TPR repeat; Region: TPR_11; pfam13414 349741003135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741003136 binding surface 349741003137 TPR motif; other site 349741003138 Tetratricopeptide repeat; Region: TPR_12; pfam13424 349741003139 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 349741003140 Competence protein A; Region: Competence_A; pfam11104 349741003141 Cell division protein FtsA; Region: FtsA; pfam14450 349741003142 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 349741003143 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 349741003144 oligomer interface [polypeptide binding]; other site 349741003145 active site 349741003146 metal binding site [ion binding]; metal-binding site 349741003147 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 349741003148 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 349741003149 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 349741003150 proline aminopeptidase P II; Provisional; Region: PRK10879 349741003151 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 349741003152 active site 349741003153 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 349741003154 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 349741003155 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 349741003156 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 349741003157 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349741003158 dimer interface [polypeptide binding]; other site 349741003159 phosphorylation site [posttranslational modification] 349741003160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741003161 ATP binding site [chemical binding]; other site 349741003162 Mg2+ binding site [ion binding]; other site 349741003163 G-X-G motif; other site 349741003164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349741003165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349741003166 active site 349741003167 phosphorylation site [posttranslational modification] 349741003168 intermolecular recognition site; other site 349741003169 dimerization interface [polypeptide binding]; other site 349741003170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349741003171 DNA binding site [nucleotide binding] 349741003172 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 349741003173 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741003174 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349741003175 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 349741003176 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 349741003177 active site 349741003178 catalytic residues [active] 349741003179 DNA binding site [nucleotide binding] 349741003180 Int/Topo IB signature motif; other site 349741003181 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 349741003182 Fe-S cluster binding site [ion binding]; other site 349741003183 active site 349741003184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741003185 Radical SAM superfamily; Region: Radical_SAM; pfam04055 349741003186 FeS/SAM binding site; other site 349741003187 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 349741003188 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 349741003189 Sulfatase; Region: Sulfatase; pfam00884 349741003190 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 349741003191 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 349741003192 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 349741003193 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 349741003194 anti sigma factor interaction site; other site 349741003195 regulatory phosphorylation site [posttranslational modification]; other site 349741003196 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 349741003197 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741003198 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 349741003199 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 349741003200 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741003201 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 349741003202 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 349741003203 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 349741003204 NAD binding site [chemical binding]; other site 349741003205 homodimer interface [polypeptide binding]; other site 349741003206 active site 349741003207 substrate binding site [chemical binding]; other site 349741003208 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 349741003209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741003210 S-adenosylmethionine binding site [chemical binding]; other site 349741003211 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 349741003212 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349741003213 nudix motif; other site 349741003214 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 349741003215 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 349741003216 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 349741003217 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 349741003218 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 349741003219 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 349741003220 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741003221 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741003222 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 349741003223 GDP-Fucose binding site [chemical binding]; other site 349741003224 Alpha 1,4-glycosyltransferase conserved region; Region: Gb3_synth; pfam04572 349741003225 Fringe-like; Region: Fringe; pfam02434 349741003226 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741003227 RHS Repeat; Region: RHS_repeat; cl11982 349741003228 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741003229 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 349741003230 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741003231 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 349741003232 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 349741003233 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 349741003234 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741003235 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349741003236 potassium-transporting ATPase subunit C; Provisional; Region: PRK14002 349741003237 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 349741003238 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 349741003239 Ligand Binding Site [chemical binding]; other site 349741003240 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 349741003241 Uncharacterized conserved protein [Function unknown]; Region: COG1262 349741003242 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 349741003243 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 349741003244 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 349741003245 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 349741003246 DNA binding residues [nucleotide binding] 349741003247 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 349741003248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349741003249 active site 349741003250 ATP binding site [chemical binding]; other site 349741003251 substrate binding site [chemical binding]; other site 349741003252 activation loop (A-loop); other site 349741003253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741003254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741003255 active site 349741003256 catalytic tetrad [active] 349741003257 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 349741003258 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 349741003259 DNA binding residues [nucleotide binding] 349741003260 putative dimer interface [polypeptide binding]; other site 349741003261 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 349741003262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 349741003263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741003264 catalytic residue [active] 349741003265 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 349741003266 metal ion-dependent adhesion site (MIDAS); other site 349741003267 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 349741003268 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 349741003269 metal ion-dependent adhesion site (MIDAS); other site 349741003270 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 349741003271 Protein of unknown function DUF58; Region: DUF58; pfam01882 349741003272 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 349741003273 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 349741003274 Walker A/P-loop; other site 349741003275 ATP binding site [chemical binding]; other site 349741003276 Q-loop/lid; other site 349741003277 ABC transporter signature motif; other site 349741003278 Walker B; other site 349741003279 D-loop; other site 349741003280 H-loop/switch region; other site 349741003281 MoxR-like ATPases [General function prediction only]; Region: COG0714 349741003282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741003283 Walker A motif; other site 349741003284 ATP binding site [chemical binding]; other site 349741003285 Walker B motif; other site 349741003286 arginine finger; other site 349741003287 Predicted membrane protein [Function unknown]; Region: COG2311 349741003288 Protein of unknown function (DUF418); Region: DUF418; pfam04235 349741003289 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 349741003290 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 349741003291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741003292 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 349741003293 NAD(P) binding site [chemical binding]; other site 349741003294 active site 349741003295 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 349741003296 ketol-acid reductoisomerase; Provisional; Region: PRK05479 349741003297 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 349741003298 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 349741003299 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 349741003300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741003301 Walker A/P-loop; other site 349741003302 ATP binding site [chemical binding]; other site 349741003303 Q-loop/lid; other site 349741003304 ABC transporter signature motif; other site 349741003305 Walker B; other site 349741003306 D-loop; other site 349741003307 H-loop/switch region; other site 349741003308 Transcriptional regulators [Transcription]; Region: FadR; COG2186 349741003309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349741003310 DNA-binding site [nucleotide binding]; DNA binding site 349741003311 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 349741003312 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741003313 Sulfatase; Region: Sulfatase; pfam00884 349741003314 Septum formation initiator; Region: DivIC; cl17659 349741003315 enolase; Provisional; Region: eno; PRK00077 349741003316 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 349741003317 dimer interface [polypeptide binding]; other site 349741003318 metal binding site [ion binding]; metal-binding site 349741003319 substrate binding pocket [chemical binding]; other site 349741003320 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 349741003321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741003322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741003323 homodimer interface [polypeptide binding]; other site 349741003324 catalytic residue [active] 349741003325 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 349741003326 ApbE family; Region: ApbE; pfam02424 349741003327 He_PIG associated, NEW1 domain of bacterial glycohydrolase; Region: He_PIG_assoc; pfam10632 349741003328 alpha-galactosidase; Region: PLN02692 349741003329 alpha-galactosidase; Region: PLN02808; cl17638 349741003330 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 349741003331 2-enoyl thioester reductase (ETR); Region: ETR; cd08290 349741003332 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 349741003333 NADP binding site [chemical binding]; other site 349741003334 dimer interface [polypeptide binding]; other site 349741003335 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 349741003336 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 349741003337 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 349741003338 Substrate binding site; other site 349741003339 Cupin domain; Region: Cupin_2; cl17218 349741003340 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 349741003341 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 349741003342 catalytic residue [active] 349741003343 putative FPP diphosphate binding site; other site 349741003344 putative FPP binding hydrophobic cleft; other site 349741003345 dimer interface [polypeptide binding]; other site 349741003346 putative IPP diphosphate binding site; other site 349741003347 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 349741003348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741003349 ATP binding site [chemical binding]; other site 349741003350 Mg2+ binding site [ion binding]; other site 349741003351 G-X-G motif; other site 349741003352 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 349741003353 anchoring element; other site 349741003354 dimer interface [polypeptide binding]; other site 349741003355 ATP binding site [chemical binding]; other site 349741003356 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 349741003357 active site 349741003358 putative metal-binding site [ion binding]; other site 349741003359 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 349741003360 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 349741003361 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 349741003362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 349741003363 DEAD_2; Region: DEAD_2; pfam06733 349741003364 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 349741003365 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 349741003366 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 349741003367 Walker A/P-loop; other site 349741003368 ATP binding site [chemical binding]; other site 349741003369 Q-loop/lid; other site 349741003370 ABC transporter signature motif; other site 349741003371 Walker B; other site 349741003372 D-loop; other site 349741003373 H-loop/switch region; other site 349741003374 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 349741003375 cobalt transport protein CbiM; Validated; Region: PRK06265 349741003376 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 349741003377 PDGLE domain; Region: PDGLE; pfam13190 349741003378 Lipocalin-like; Region: Lipocalin_3; pfam12702 349741003379 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 349741003380 nucleotide binding site [chemical binding]; other site 349741003381 substrate binding site [chemical binding]; other site 349741003382 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 349741003383 uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; Region: EcCorA-like_u1; cd12837 349741003384 Cl binding site [ion binding]; other site 349741003385 oligomer interface [polypeptide binding]; other site 349741003386 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 349741003387 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 349741003388 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 349741003389 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 349741003390 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 349741003391 purine monophosphate binding site [chemical binding]; other site 349741003392 dimer interface [polypeptide binding]; other site 349741003393 putative catalytic residues [active] 349741003394 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 349741003395 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 349741003396 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 349741003397 active site 349741003398 hydrophilic channel; other site 349741003399 dimerization interface [polypeptide binding]; other site 349741003400 catalytic residues [active] 349741003401 active site lid [active] 349741003402 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 349741003403 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 349741003404 active site 349741003405 substrate-binding site [chemical binding]; other site 349741003406 metal-binding site [ion binding] 349741003407 GTP binding site [chemical binding]; other site 349741003408 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 349741003409 amidase catalytic site [active] 349741003410 Zn binding residues [ion binding]; other site 349741003411 substrate binding site [chemical binding]; other site 349741003412 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 349741003413 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 349741003414 ssDNA binding site; other site 349741003415 generic binding surface II; other site 349741003416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741003417 ATP binding site [chemical binding]; other site 349741003418 putative Mg++ binding site [ion binding]; other site 349741003419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741003420 nucleotide binding region [chemical binding]; other site 349741003421 ATP-binding site [chemical binding]; other site 349741003422 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 349741003423 molybdopterin cofactor binding site; other site 349741003424 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 349741003425 molybdopterin cofactor binding site; other site 349741003426 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 349741003427 4Fe-4S binding domain; Region: Fer4; cl02805 349741003428 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 349741003429 heme-binding residues [chemical binding]; other site 349741003430 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 349741003431 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349741003432 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 349741003433 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 349741003434 active site 349741003435 dimer interface [polypeptide binding]; other site 349741003436 metal binding site [ion binding]; metal-binding site 349741003437 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 349741003438 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 349741003439 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 349741003440 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 349741003441 OPT oligopeptide transporter protein; Region: OPT; pfam03169 349741003442 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 349741003443 active site 349741003444 dimer interface [polypeptide binding]; other site 349741003445 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 349741003446 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 349741003447 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 349741003448 DRTGG domain; Region: DRTGG; pfam07085 349741003449 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 349741003450 DHH family; Region: DHH; pfam01368 349741003451 DHHA2 domain; Region: DHHA2; pfam02833 349741003452 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 349741003453 putative catalytic site [active] 349741003454 putative phosphate binding site [ion binding]; other site 349741003455 hypothetical protein; Validated; Region: PRK00153 349741003456 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 349741003457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741003458 Walker A motif; other site 349741003459 ATP binding site [chemical binding]; other site 349741003460 Walker B motif; other site 349741003461 arginine finger; other site 349741003462 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 349741003463 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 349741003464 hypothetical protein; Reviewed; Region: PRK00024 349741003465 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 349741003466 MPN+ (JAMM) motif; other site 349741003467 Zinc-binding site [ion binding]; other site 349741003468 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 349741003469 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 349741003470 putative substrate binding site [chemical binding]; other site 349741003471 putative ATP binding site [chemical binding]; other site 349741003472 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 349741003473 rRNA binding site [nucleotide binding]; other site 349741003474 predicted 30S ribosome binding site; other site 349741003475 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 349741003476 23S rRNA interface [nucleotide binding]; other site 349741003477 L3 interface [polypeptide binding]; other site 349741003478 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 349741003479 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 349741003480 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 349741003481 active site 349741003482 catalytic site [active] 349741003483 putative DNA binding site [nucleotide binding]; other site 349741003484 GIY-YIG motif/motif A; other site 349741003485 metal binding site [ion binding]; metal-binding site 349741003486 UvrB/uvrC motif; Region: UVR; pfam02151 349741003487 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 349741003488 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 349741003489 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 349741003490 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 349741003491 Transglycosylase; Region: Transgly; pfam00912 349741003492 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 349741003493 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 349741003494 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 349741003495 dimerization interface [polypeptide binding]; other site 349741003496 active site 349741003497 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 349741003498 homotrimer interaction site [polypeptide binding]; other site 349741003499 zinc binding site [ion binding]; other site 349741003500 CDP-binding sites; other site 349741003501 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 349741003502 amidase catalytic site [active] 349741003503 Zn binding residues [ion binding]; other site 349741003504 substrate binding site [chemical binding]; other site 349741003505 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 349741003506 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 349741003507 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 349741003508 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 349741003509 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 349741003510 NADP binding site [chemical binding]; other site 349741003511 active site 349741003512 putative substrate binding site [chemical binding]; other site 349741003513 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 349741003514 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 349741003515 NADP-binding site; other site 349741003516 homotetramer interface [polypeptide binding]; other site 349741003517 substrate binding site [chemical binding]; other site 349741003518 homodimer interface [polypeptide binding]; other site 349741003519 active site 349741003520 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 349741003521 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 349741003522 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 349741003523 catalytic site [active] 349741003524 subunit interface [polypeptide binding]; other site 349741003525 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 349741003526 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349741003527 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 349741003528 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 349741003529 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 349741003530 ATP-grasp domain; Region: ATP-grasp_4; cl17255 349741003531 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 349741003532 IMP binding site; other site 349741003533 dimer interface [polypeptide binding]; other site 349741003534 interdomain contacts; other site 349741003535 partial ornithine binding site; other site 349741003536 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 349741003537 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 349741003538 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 349741003539 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 349741003540 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 349741003541 active site 349741003542 dimer interface [polypeptide binding]; other site 349741003543 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 349741003544 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 349741003545 active site 349741003546 FMN binding site [chemical binding]; other site 349741003547 substrate binding site [chemical binding]; other site 349741003548 3Fe-4S cluster binding site [ion binding]; other site 349741003549 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 349741003550 domain interface; other site 349741003551 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 349741003552 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 349741003553 Haemolytic domain; Region: Haemolytic; pfam01809 349741003554 Ribonuclease P; Region: Ribonuclease_P; pfam00825 349741003555 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 349741003556 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 349741003557 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 349741003558 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 349741003559 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 349741003560 active site 349741003561 catalytic triad [active] 349741003562 oxyanion hole [active] 349741003563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 349741003564 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741003565 active site 349741003566 catalytic triad [active] 349741003567 oxyanion hole [active] 349741003568 Trehalase; Region: Trehalase; cl17346 349741003569 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 349741003570 active site 349741003571 phosphate binding residues; other site 349741003572 catalytic residues [active] 349741003573 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 349741003574 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 349741003575 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 349741003576 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 349741003577 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 349741003578 dimerization interface [polypeptide binding]; other site 349741003579 active site 349741003580 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 349741003581 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 349741003582 substrate binding pocket [chemical binding]; other site 349741003583 chain length determination region; other site 349741003584 substrate-Mg2+ binding site; other site 349741003585 catalytic residues [active] 349741003586 aspartate-rich region 1; other site 349741003587 active site lid residues [active] 349741003588 aspartate-rich region 2; other site 349741003589 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 349741003590 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 349741003591 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 349741003592 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 349741003593 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 349741003594 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 349741003595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 349741003596 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349741003597 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 349741003598 active site 349741003599 catalytic triad [active] 349741003600 oxyanion hole [active] 349741003601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741003602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 349741003603 Coenzyme A binding pocket [chemical binding]; other site 349741003604 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 349741003605 active site 349741003606 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 349741003607 putative cation:proton antiport protein; Provisional; Region: PRK10669 349741003608 TrkA-N domain; Region: TrkA_N; pfam02254 349741003609 phosphodiesterase YaeI; Provisional; Region: PRK11340 349741003610 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 349741003611 putative active site [active] 349741003612 putative metal binding site [ion binding]; other site 349741003613 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 349741003614 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 349741003615 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 349741003616 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 349741003617 active site 349741003618 substrate binding site [chemical binding]; other site 349741003619 cosubstrate binding site; other site 349741003620 catalytic site [active] 349741003621 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 349741003622 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 349741003623 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 349741003624 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741003625 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 349741003626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741003627 ATP binding site [chemical binding]; other site 349741003628 Mg2+ binding site [ion binding]; other site 349741003629 G-X-G motif; other site 349741003630 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 349741003631 anchoring element; other site 349741003632 dimer interface [polypeptide binding]; other site 349741003633 ATP binding site [chemical binding]; other site 349741003634 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 349741003635 active site 349741003636 putative metal-binding site [ion binding]; other site 349741003637 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 349741003638 DNA gyrase subunit A; Validated; Region: PRK05560 349741003639 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 349741003640 CAP-like domain; other site 349741003641 active site 349741003642 primary dimer interface [polypeptide binding]; other site 349741003643 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349741003644 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349741003645 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349741003646 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349741003647 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 349741003648 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 349741003649 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 349741003650 Peptidase family U32; Region: Peptidase_U32; pfam01136 349741003651 Uncharacterized conserved protein [Function unknown]; Region: COG1262 349741003652 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 349741003653 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 349741003654 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 349741003655 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 349741003656 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 349741003657 homotrimer interaction site [polypeptide binding]; other site 349741003658 putative active site [active] 349741003659 sulfite reductase subunit beta; Provisional; Region: PRK13504 349741003660 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 349741003661 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 349741003662 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 349741003663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741003664 dimer interface [polypeptide binding]; other site 349741003665 conserved gate region; other site 349741003666 putative PBP binding loops; other site 349741003667 ABC-ATPase subunit interface; other site 349741003668 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 349741003669 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 349741003670 Walker A/P-loop; other site 349741003671 ATP binding site [chemical binding]; other site 349741003672 Q-loop/lid; other site 349741003673 ABC transporter signature motif; other site 349741003674 Walker B; other site 349741003675 D-loop; other site 349741003676 H-loop/switch region; other site 349741003677 NMT1-like family; Region: NMT1_2; pfam13379 349741003678 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 349741003679 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 349741003680 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 349741003681 CysD dimerization site [polypeptide binding]; other site 349741003682 G1 box; other site 349741003683 putative GEF interaction site [polypeptide binding]; other site 349741003684 GTP/Mg2+ binding site [chemical binding]; other site 349741003685 Switch I region; other site 349741003686 G2 box; other site 349741003687 G3 box; other site 349741003688 Switch II region; other site 349741003689 G4 box; other site 349741003690 G5 box; other site 349741003691 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 349741003692 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 349741003693 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 349741003694 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 349741003695 Active Sites [active] 349741003696 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 349741003697 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 349741003698 Active Sites [active] 349741003699 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 349741003700 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 349741003701 dimer interface [polypeptide binding]; other site 349741003702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741003703 catalytic residue [active] 349741003704 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 349741003705 PhoU domain; Region: PhoU; pfam01895 349741003706 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 349741003707 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 349741003708 Walker A/P-loop; other site 349741003709 ATP binding site [chemical binding]; other site 349741003710 Q-loop/lid; other site 349741003711 ABC transporter signature motif; other site 349741003712 Walker B; other site 349741003713 D-loop; other site 349741003714 H-loop/switch region; other site 349741003715 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 349741003716 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 349741003717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741003718 dimer interface [polypeptide binding]; other site 349741003719 conserved gate region; other site 349741003720 putative PBP binding loops; other site 349741003721 ABC-ATPase subunit interface; other site 349741003722 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 349741003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741003724 conserved gate region; other site 349741003725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741003726 ABC-ATPase subunit interface; other site 349741003727 PBP superfamily domain; Region: PBP_like_2; cl17296 349741003728 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 349741003729 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 349741003730 Walker A/P-loop; other site 349741003731 ATP binding site [chemical binding]; other site 349741003732 Q-loop/lid; other site 349741003733 ABC transporter signature motif; other site 349741003734 Walker B; other site 349741003735 D-loop; other site 349741003736 H-loop/switch region; other site 349741003737 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 349741003738 PhoU domain; Region: PhoU; pfam01895 349741003739 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 349741003740 active site 349741003741 catalytic residues [active] 349741003742 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 349741003743 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 349741003744 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 349741003745 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 349741003746 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 349741003747 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 349741003748 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 349741003749 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 349741003750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741003751 Radical SAM superfamily; Region: Radical_SAM; pfam04055 349741003752 FeS/SAM binding site; other site 349741003753 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 349741003754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349741003755 MarR family; Region: MarR_2; pfam12802 349741003756 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 349741003757 ribosome recycling factor; Reviewed; Region: frr; PRK00083 349741003758 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 349741003759 hinge region; other site 349741003760 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 349741003761 putative nucleotide binding site [chemical binding]; other site 349741003762 uridine monophosphate binding site [chemical binding]; other site 349741003763 homohexameric interface [polypeptide binding]; other site 349741003764 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 349741003765 Mechanosensitive ion channel; Region: MS_channel; pfam00924 349741003766 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 349741003767 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 349741003768 dimer interface [polypeptide binding]; other site 349741003769 decamer (pentamer of dimers) interface [polypeptide binding]; other site 349741003770 catalytic triad [active] 349741003771 peroxidatic and resolving cysteines [active] 349741003772 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 349741003773 Na binding site [ion binding]; other site 349741003774 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 349741003775 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 349741003776 recombination protein RecR; Reviewed; Region: recR; PRK00076 349741003777 RecR protein; Region: RecR; pfam02132 349741003778 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 349741003779 putative active site [active] 349741003780 putative metal-binding site [ion binding]; other site 349741003781 tetramer interface [polypeptide binding]; other site 349741003782 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 349741003783 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 349741003784 dimer interface [polypeptide binding]; other site 349741003785 active site 349741003786 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 349741003787 methionine sulfoxide reductase B; Provisional; Region: PRK05508 349741003788 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 349741003789 active site 349741003790 DNA polymerase IV; Validated; Region: PRK02406 349741003791 DNA binding site [nucleotide binding] 349741003792 TLC ATP/ADP transporter; Region: TLC; cl03940 349741003793 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 349741003794 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 349741003795 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 349741003796 tandem repeat interface [polypeptide binding]; other site 349741003797 oligomer interface [polypeptide binding]; other site 349741003798 active site residues [active] 349741003799 PA14 domain; Region: PA14; cl08459 349741003800 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 349741003801 hypothetical protein; Provisional; Region: PRK09126 349741003802 tape measure domain; Region: tape_meas_nterm; TIGR02675 349741003803 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 349741003804 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 349741003805 type III secretion system chaperone YscW; Region: YscW; TIGR02567 349741003806 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 349741003807 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 349741003808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 349741003809 non-specific DNA binding site [nucleotide binding]; other site 349741003810 salt bridge; other site 349741003811 sequence-specific DNA binding site [nucleotide binding]; other site 349741003812 YcfA-like protein; Region: YcfA; pfam07927 349741003813 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 349741003814 Helix-turn-helix domain; Region: HTH_17; cl17695 349741003815 Prophage antirepressor [Transcription]; Region: COG3617 349741003816 BRO family, N-terminal domain; Region: Bro-N; smart01040 349741003817 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 349741003818 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 349741003819 replicative DNA helicase; Region: DnaB; TIGR00665 349741003820 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 349741003821 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 349741003822 Walker A motif; other site 349741003823 ATP binding site [chemical binding]; other site 349741003824 Walker B motif; other site 349741003825 DNA binding loops [nucleotide binding] 349741003826 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 349741003827 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 349741003828 active site 349741003829 catalytic residues [active] 349741003830 DNA binding site [nucleotide binding] 349741003831 Int/Topo IB signature motif; other site 349741003832 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 349741003833 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 349741003834 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 349741003835 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 349741003836 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 349741003837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 349741003838 Walker A/P-loop; other site 349741003839 ATP binding site [chemical binding]; other site 349741003840 Q-loop/lid; other site 349741003841 ABC transporter signature motif; other site 349741003842 Walker B; other site 349741003843 D-loop; other site 349741003844 H-loop/switch region; other site 349741003845 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741003846 Walker A/P-loop; other site 349741003847 ATP binding site [chemical binding]; other site 349741003848 Q-loop/lid; other site 349741003849 ABC transporter signature motif; other site 349741003850 Walker B; other site 349741003851 D-loop; other site 349741003852 H-loop/switch region; other site 349741003853 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 349741003854 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741003855 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 349741003856 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 349741003857 motif 1; other site 349741003858 active site 349741003859 motif 2; other site 349741003860 motif 3; other site 349741003861 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 349741003862 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 349741003863 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 349741003864 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 349741003865 dihydropteroate synthase; Region: DHPS; TIGR01496 349741003866 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 349741003867 substrate binding pocket [chemical binding]; other site 349741003868 dimer interface [polypeptide binding]; other site 349741003869 inhibitor binding site; inhibition site 349741003870 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 349741003871 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048 349741003872 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 349741003873 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 349741003874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 349741003875 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 349741003876 NAD(P) binding site [chemical binding]; other site 349741003877 active site 349741003878 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 349741003879 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741003880 Abhydrolase family; Region: Abhydrolase_7; pfam12715 349741003881 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 349741003882 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 349741003883 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 349741003884 active site 349741003885 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 349741003886 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 349741003887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741003888 catalytic residue [active] 349741003889 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 349741003890 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 349741003891 dimer interface [polypeptide binding]; other site 349741003892 anticodon binding site; other site 349741003893 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 349741003894 homodimer interface [polypeptide binding]; other site 349741003895 motif 1; other site 349741003896 active site 349741003897 motif 2; other site 349741003898 GAD domain; Region: GAD; pfam02938 349741003899 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 349741003900 active site 349741003901 motif 3; other site 349741003902 histidyl-tRNA synthetase; Region: hisS; TIGR00442 349741003903 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 349741003904 dimer interface [polypeptide binding]; other site 349741003905 motif 1; other site 349741003906 active site 349741003907 motif 2; other site 349741003908 motif 3; other site 349741003909 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 349741003910 anticodon binding site; other site 349741003911 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349741003912 Acylphosphatase; Region: Acylphosphatase; pfam00708 349741003913 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 349741003914 HypF finger; Region: zf-HYPF; pfam07503 349741003915 HypF finger; Region: zf-HYPF; pfam07503 349741003916 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 349741003917 HupF/HypC family; Region: HupF_HypC; pfam01455 349741003918 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 349741003919 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 349741003920 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 349741003921 dimerization interface [polypeptide binding]; other site 349741003922 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 349741003923 ATP binding site [chemical binding]; other site 349741003924 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741003925 Sel1-like repeats; Region: SEL1; smart00671 349741003926 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741003927 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 349741003928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349741003929 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 349741003930 putative active site [active] 349741003931 putative metal binding site [ion binding]; other site 349741003932 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 349741003933 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 349741003934 nucleotide binding site [chemical binding]; other site 349741003935 NEF interaction site [polypeptide binding]; other site 349741003936 SBD interface [polypeptide binding]; other site 349741003937 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 349741003938 oligomerisation interface [polypeptide binding]; other site 349741003939 mobile loop; other site 349741003940 roof hairpin; other site 349741003941 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 349741003942 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 349741003943 ring oligomerisation interface [polypeptide binding]; other site 349741003944 ATP/Mg binding site [chemical binding]; other site 349741003945 stacking interactions; other site 349741003946 hinge regions; other site 349741003947 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 349741003948 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 349741003949 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 349741003950 Chain length determinant protein; Region: Wzz; cl15801 349741003951 Chain length determinant protein; Region: Wzz; cl15801 349741003952 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 349741003953 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349741003954 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 349741003955 SLBB domain; Region: SLBB; pfam10531 349741003956 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 349741003957 RuvA N terminal domain; Region: RuvA_N; pfam01330 349741003958 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 349741003959 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 349741003960 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 349741003961 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 349741003962 Phosphoglycerate kinase; Region: PGK; pfam00162 349741003963 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 349741003964 substrate binding site [chemical binding]; other site 349741003965 hinge regions; other site 349741003966 ADP binding site [chemical binding]; other site 349741003967 catalytic site [active] 349741003968 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 349741003969 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 349741003970 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349741003971 active site 349741003972 ATP binding site [chemical binding]; other site 349741003973 substrate binding site [chemical binding]; other site 349741003974 activation loop (A-loop); other site 349741003975 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741003976 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 349741003977 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 349741003978 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 349741003979 Kelch motif; Region: Kelch_1; pfam01344 349741003980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741003981 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349741003982 putative substrate translocation pore; other site 349741003983 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 349741003984 Galactose oxidase, central domain; Region: Kelch_3; cl02701 349741003985 Galactose oxidase, central domain; Region: Kelch_3; cl02701 349741003986 histidinol-phosphatase; Provisional; Region: PRK07328 349741003987 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 349741003988 active site 349741003989 dimer interface [polypeptide binding]; other site 349741003990 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 349741003991 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 349741003992 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 349741003993 Ligand Binding Site [chemical binding]; other site 349741003994 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 349741003995 NlpE N-terminal domain; Region: NlpE; pfam04170 349741003996 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 349741003997 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 349741003998 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 349741003999 malate dehydrogenase; Provisional; Region: PRK05442 349741004000 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 349741004001 NAD(P) binding site [chemical binding]; other site 349741004002 dimer interface [polypeptide binding]; other site 349741004003 malate binding site [chemical binding]; other site 349741004004 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 349741004005 Putative peptidase family; Region: Metallopep; pfam12044 349741004006 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 349741004007 active site 349741004008 NPCBM/NEW2 domain; Region: NPCBM; cl07060 349741004009 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 349741004010 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 349741004011 dimer interface [polypeptide binding]; other site 349741004012 FMN binding site [chemical binding]; other site 349741004013 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 349741004014 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 349741004015 active site 349741004016 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 349741004017 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349741004018 RNA binding surface [nucleotide binding]; other site 349741004019 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 349741004020 active site 349741004021 uracil binding [chemical binding]; other site 349741004022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741004023 binding surface 349741004024 TPR motif; other site 349741004025 AAA domain; Region: AAA_33; pfam13671 349741004026 AAA domain; Region: AAA_17; pfam13207 349741004027 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 349741004028 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 349741004029 Walker A/P-loop; other site 349741004030 ATP binding site [chemical binding]; other site 349741004031 Q-loop/lid; other site 349741004032 ABC transporter signature motif; other site 349741004033 Walker B; other site 349741004034 D-loop; other site 349741004035 H-loop/switch region; other site 349741004036 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 349741004037 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 349741004038 substrate binding pocket [chemical binding]; other site 349741004039 membrane-bound complex binding site; other site 349741004040 hinge residues; other site 349741004041 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 349741004042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741004043 dimer interface [polypeptide binding]; other site 349741004044 conserved gate region; other site 349741004045 putative PBP binding loops; other site 349741004046 ABC-ATPase subunit interface; other site 349741004047 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 349741004048 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 349741004049 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 349741004050 heterotetramer interface [polypeptide binding]; other site 349741004051 active site pocket [active] 349741004052 cleavage site 349741004053 Flagellin N-methylase; Region: FliB; cl00497 349741004054 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741004055 Sel1-like repeats; Region: SEL1; smart00671 349741004056 Sel1-like repeats; Region: SEL1; smart00671 349741004057 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741004058 Sel1-like repeats; Region: SEL1; smart00671 349741004059 Sel1-like repeats; Region: SEL1; smart00671 349741004060 Sel1-like repeats; Region: SEL1; smart00671 349741004061 Sel1-like repeats; Region: SEL1; smart00671 349741004062 Sel1-like repeats; Region: SEL1; smart00671 349741004063 Sel1-like repeats; Region: SEL1; smart00671 349741004064 Sel1-like repeats; Region: SEL1; smart00671 349741004065 Mac 1; Region: Mac-1; pfam09028 349741004066 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 349741004067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741004068 Walker A/P-loop; other site 349741004069 ATP binding site [chemical binding]; other site 349741004070 Q-loop/lid; other site 349741004071 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 349741004072 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349741004073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741004074 Walker A/P-loop; other site 349741004075 ATP binding site [chemical binding]; other site 349741004076 Q-loop/lid; other site 349741004077 ABC transporter signature motif; other site 349741004078 Walker B; other site 349741004079 D-loop; other site 349741004080 H-loop/switch region; other site 349741004081 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 349741004082 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 349741004083 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 349741004084 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 349741004085 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 349741004086 active site 349741004087 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 349741004088 GrpE; Region: GrpE; pfam01025 349741004089 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 349741004090 dimer interface [polypeptide binding]; other site 349741004091 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 349741004092 chaperone protein DnaJ; Provisional; Region: PRK10767 349741004093 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 349741004094 HSP70 interaction site [polypeptide binding]; other site 349741004095 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 349741004096 substrate binding site [polypeptide binding]; other site 349741004097 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 349741004098 Zn binding sites [ion binding]; other site 349741004099 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 349741004100 dimer interface [polypeptide binding]; other site 349741004101 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 349741004102 RNA methyltransferase, RsmE family; Region: TIGR00046 349741004103 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 349741004104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741004105 motif II; other site 349741004106 Dihydroneopterin aldolase; Region: FolB; smart00905 349741004107 active site 349741004108 Right handed beta helix region; Region: Beta_helix; pfam13229 349741004109 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 349741004110 active site lid residues [active] 349741004111 substrate binding pocket [chemical binding]; other site 349741004112 catalytic residues [active] 349741004113 substrate-Mg2+ binding site; other site 349741004114 aspartate-rich region 1; other site 349741004115 aspartate-rich region 2; other site 349741004116 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 349741004117 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 349741004118 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 349741004119 Catalytic site [active] 349741004120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 349741004121 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 349741004122 FAD binding domain; Region: FAD_binding_4; pfam01565 349741004123 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 349741004124 putative heme binding site [chemical binding]; other site 349741004125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 349741004126 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 349741004127 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 349741004128 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 349741004129 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 349741004130 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 349741004131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349741004132 active site 349741004133 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 349741004134 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 349741004135 5S rRNA interface [nucleotide binding]; other site 349741004136 CTC domain interface [polypeptide binding]; other site 349741004137 L16 interface [polypeptide binding]; other site 349741004138 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 349741004139 putative active site pocket [active] 349741004140 4-fold oligomerization interface [polypeptide binding]; other site 349741004141 metal binding residues [ion binding]; metal-binding site 349741004142 3-fold/trimer interface [polypeptide binding]; other site 349741004143 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 349741004144 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 349741004145 putative active site [active] 349741004146 oxyanion strand; other site 349741004147 catalytic triad [active] 349741004148 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 349741004149 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 349741004150 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 349741004151 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 349741004152 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 349741004153 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 349741004154 6-phosphofructokinase; Provisional; Region: PRK03202 349741004155 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 349741004156 active site 349741004157 ADP/pyrophosphate binding site [chemical binding]; other site 349741004158 dimerization interface [polypeptide binding]; other site 349741004159 allosteric effector site; other site 349741004160 fructose-1,6-bisphosphate binding site; other site 349741004161 Protein of unknown function (DUF805); Region: DUF805; pfam05656 349741004162 zinc transporter ZupT; Provisional; Region: PRK04201 349741004163 ZIP Zinc transporter; Region: Zip; pfam02535 349741004164 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 349741004165 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 349741004166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741004167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004168 homodimer interface [polypeptide binding]; other site 349741004169 catalytic residue [active] 349741004170 hypothetical protein; Provisional; Region: PRK11820 349741004171 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 349741004172 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 349741004173 Guanylate kinase; Region: Guanylate_kin; pfam00625 349741004174 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 349741004175 catalytic site [active] 349741004176 G-X2-G-X-G-K; other site 349741004177 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 349741004178 TrkA-C domain; Region: TrkA_C; pfam02080 349741004179 TrkA-C domain; Region: TrkA_C; pfam02080 349741004180 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 349741004181 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 349741004182 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 349741004183 active site 349741004184 HIGH motif; other site 349741004185 nucleotide binding site [chemical binding]; other site 349741004186 active site 349741004187 KMSKS motif; other site 349741004188 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 349741004189 UbiA prenyltransferase family; Region: UbiA; pfam01040 349741004190 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 349741004191 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 349741004192 active site 349741004193 catalytic residue [active] 349741004194 dimer interface [polypeptide binding]; other site 349741004195 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 349741004196 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 349741004197 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 349741004198 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 349741004199 NodB motif; other site 349741004200 active site 349741004201 catalytic site [active] 349741004202 metal binding site [ion binding]; metal-binding site 349741004203 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 349741004204 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 349741004205 Protein export membrane protein; Region: SecD_SecF; pfam02355 349741004206 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 349741004207 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 349741004208 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 349741004209 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 349741004210 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 349741004211 alphaNTD homodimer interface [polypeptide binding]; other site 349741004212 alphaNTD - beta interaction site [polypeptide binding]; other site 349741004213 alphaNTD - beta' interaction site [polypeptide binding]; other site 349741004214 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 349741004215 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 349741004216 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 349741004217 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 349741004218 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 349741004219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741004220 motif II; other site 349741004221 Predicted permeases [General function prediction only]; Region: COG0795 349741004222 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 349741004223 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 349741004224 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 349741004225 ligand binding site [chemical binding]; other site 349741004226 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 349741004227 Peptidase M60-like family; Region: M60-like; pfam13402 349741004228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741004229 H+ Antiporter protein; Region: 2A0121; TIGR00900 349741004230 putative substrate translocation pore; other site 349741004231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 349741004232 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 349741004233 putative active site [active] 349741004234 heme pocket [chemical binding]; other site 349741004235 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 349741004236 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 349741004237 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 349741004238 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349741004239 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 349741004240 putative catalytic site [active] 349741004241 putative metal binding site [ion binding]; other site 349741004242 putative phosphate binding site [ion binding]; other site 349741004243 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 349741004244 putative active site [active] 349741004245 catalytic site [active] 349741004246 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 349741004247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741004248 ATP binding site [chemical binding]; other site 349741004249 putative Mg++ binding site [ion binding]; other site 349741004250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741004251 nucleotide binding region [chemical binding]; other site 349741004252 ATP-binding site [chemical binding]; other site 349741004253 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 349741004254 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 349741004255 DNA methylase; Region: N6_N4_Mtase; pfam01555 349741004256 DNA methylase; Region: N6_N4_Mtase; cl17433 349741004257 Restriction endonuclease [Defense mechanisms]; Region: COG3587 349741004258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741004259 ATP binding site [chemical binding]; other site 349741004260 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 349741004261 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 349741004262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741004263 active site 349741004264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741004265 catalytic tetrad [active] 349741004266 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 349741004267 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 349741004268 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 349741004269 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 349741004270 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 349741004271 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 349741004272 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 349741004273 glutamine binding [chemical binding]; other site 349741004274 catalytic triad [active] 349741004275 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 349741004276 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 349741004277 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 349741004278 active site 349741004279 ribulose/triose binding site [chemical binding]; other site 349741004280 phosphate binding site [ion binding]; other site 349741004281 substrate (anthranilate) binding pocket [chemical binding]; other site 349741004282 product (indole) binding pocket [chemical binding]; other site 349741004283 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 349741004284 active site 349741004285 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 349741004286 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 349741004287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004288 catalytic residue [active] 349741004289 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 349741004290 substrate binding site [chemical binding]; other site 349741004291 active site 349741004292 catalytic residues [active] 349741004293 heterodimer interface [polypeptide binding]; other site 349741004294 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741004295 OsmC-like protein; Region: OsmC; pfam02566 349741004296 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 349741004297 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 349741004298 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 349741004299 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 349741004300 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 349741004301 putative acyl-acceptor binding pocket; other site 349741004302 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741004303 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 349741004304 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741004305 FeS/SAM binding site; other site 349741004306 Pyruvate formate lyase 1; Region: PFL1; cd01678 349741004307 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 349741004308 coenzyme A binding site [chemical binding]; other site 349741004309 active site 349741004310 catalytic residues [active] 349741004311 glycine loop; other site 349741004312 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741004313 active site 349741004314 catalytic triad [active] 349741004315 oxyanion hole [active] 349741004316 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741004317 active site 349741004318 catalytic triad [active] 349741004319 oxyanion hole [active] 349741004320 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 349741004321 dimer interface [polypeptide binding]; other site 349741004322 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 349741004323 Asp-box motif; other site 349741004324 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 349741004325 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 349741004326 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 349741004327 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 349741004328 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 349741004329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741004330 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 349741004331 active site 349741004332 motif I; other site 349741004333 motif II; other site 349741004334 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 349741004335 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 349741004336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741004337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349741004338 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 349741004339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741004340 ATP binding site [chemical binding]; other site 349741004341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741004342 nucleotide binding region [chemical binding]; other site 349741004343 ATP-binding site [chemical binding]; other site 349741004344 Ultra-violet resistance protein B; Region: UvrB; pfam12344 349741004345 UvrB/uvrC motif; Region: UVR; pfam02151 349741004346 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 349741004347 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 349741004348 23S rRNA binding site [nucleotide binding]; other site 349741004349 L21 binding site [polypeptide binding]; other site 349741004350 L13 binding site [polypeptide binding]; other site 349741004351 RIP metalloprotease RseP; Region: TIGR00054 349741004352 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 349741004353 active site 349741004354 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 349741004355 protein binding site [polypeptide binding]; other site 349741004356 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 349741004357 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 349741004358 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 349741004359 Family description; Region: UvrD_C_2; pfam13538 349741004360 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 349741004361 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 349741004362 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 349741004363 EamA-like transporter family; Region: EamA; pfam00892 349741004364 EamA-like transporter family; Region: EamA; pfam00892 349741004365 Dam-replacing family; Region: DRP; pfam06044 349741004366 MG2 domain; Region: A2M_N; pfam01835 349741004367 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 349741004368 Alpha-2-macroglobulin family; Region: A2M; pfam00207 349741004369 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 349741004370 surface patch; other site 349741004371 thioester region; other site 349741004372 specificity defining residues; other site 349741004373 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 349741004374 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 349741004375 dimer interface [polypeptide binding]; other site 349741004376 active site 349741004377 metal binding site [ion binding]; metal-binding site 349741004378 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 349741004379 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 349741004380 DNA binding site [nucleotide binding] 349741004381 active site 349741004382 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 349741004383 Glycoprotease family; Region: Peptidase_M22; pfam00814 349741004384 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 349741004385 Citrate synthase; Region: Citrate_synt; pfam00285 349741004386 oxalacetate binding site [chemical binding]; other site 349741004387 citrylCoA binding site [chemical binding]; other site 349741004388 coenzyme A binding site [chemical binding]; other site 349741004389 catalytic triad [active] 349741004390 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 349741004391 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 349741004392 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 349741004393 SmpB-tmRNA interface; other site 349741004394 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 349741004395 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 349741004396 pseudouridine synthase; Region: TIGR00093 349741004397 active site 349741004398 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 349741004399 active site 349741004400 multimer interface [polypeptide binding]; other site 349741004401 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349741004402 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 349741004403 metal-binding site 349741004404 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 349741004405 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 349741004406 Ligand binding site; other site 349741004407 Putative Catalytic site; other site 349741004408 DXD motif; other site 349741004409 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 349741004410 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 349741004411 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 349741004412 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 349741004413 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 349741004414 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 349741004415 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 349741004416 Walker A motif; other site 349741004417 ATP binding site [chemical binding]; other site 349741004418 Walker B motif; other site 349741004419 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 349741004420 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 349741004421 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 349741004422 Walker A motif; other site 349741004423 ATP binding site [chemical binding]; other site 349741004424 Walker B motif; other site 349741004425 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 349741004426 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 349741004427 FMN binding site [chemical binding]; other site 349741004428 active site 349741004429 catalytic residues [active] 349741004430 substrate binding site [chemical binding]; other site 349741004431 Protein of unknown function (DUF964); Region: DUF964; cl01483 349741004432 aspartate aminotransferase; Provisional; Region: PRK05764 349741004433 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741004434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004435 homodimer interface [polypeptide binding]; other site 349741004436 catalytic residue [active] 349741004437 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 349741004438 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 349741004439 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741004440 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 349741004441 active site 349741004442 nucleotide binding site [chemical binding]; other site 349741004443 HIGH motif; other site 349741004444 KMSKS motif; other site 349741004445 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 349741004446 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 349741004447 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 349741004448 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 349741004449 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 349741004450 AIR carboxylase; Region: AIRC; smart01001 349741004451 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 349741004452 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 349741004453 Ligand Binding Site [chemical binding]; other site 349741004454 Protein of unknown function DUF111; Region: DUF111; pfam01969 349741004455 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 349741004456 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 349741004457 substrate binding pocket [chemical binding]; other site 349741004458 chain length determination region; other site 349741004459 substrate-Mg2+ binding site; other site 349741004460 catalytic residues [active] 349741004461 aspartate-rich region 1; other site 349741004462 active site lid residues [active] 349741004463 aspartate-rich region 2; other site 349741004464 POT family; Region: PTR2; cl17359 349741004465 POT family; Region: PTR2; cl17359 349741004466 SurA N-terminal domain; Region: SurA_N_3; cl07813 349741004467 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 349741004468 Domain of unknown function DUF59; Region: DUF59; cl00941 349741004469 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 349741004470 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00197 349741004471 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 349741004472 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00150 349741004473 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 349741004474 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 349741004475 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 349741004476 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 349741004477 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 349741004478 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 349741004479 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 349741004480 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 349741004481 4Fe-4S binding domain; Region: Fer4; pfam00037 349741004482 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 349741004483 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 349741004484 catalytic loop [active] 349741004485 iron binding site [ion binding]; other site 349741004486 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 349741004487 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 349741004488 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 349741004489 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 349741004490 SLBB domain; Region: SLBB; pfam10531 349741004491 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 349741004492 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 349741004493 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 349741004494 putative dimer interface [polypeptide binding]; other site 349741004495 [2Fe-2S] cluster binding site [ion binding]; other site 349741004496 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 349741004497 NADH dehydrogenase subunit D; Validated; Region: PRK06075 349741004498 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 349741004499 putative active site [active] 349741004500 putative metal binding site [ion binding]; other site 349741004501 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 349741004502 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 349741004503 Lumazine binding domain; Region: Lum_binding; pfam00677 349741004504 Lumazine binding domain; Region: Lum_binding; pfam00677 349741004505 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 349741004506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741004507 S-adenosylmethionine binding site [chemical binding]; other site 349741004508 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741004509 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 349741004510 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 349741004511 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 349741004512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741004513 FeS/SAM binding site; other site 349741004514 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 349741004515 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 349741004516 dimer interface [polypeptide binding]; other site 349741004517 active site residues [active] 349741004518 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 349741004519 DNA primase; Validated; Region: dnaG; PRK05667 349741004520 CHC2 zinc finger; Region: zf-CHC2; pfam01807 349741004521 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 349741004522 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 349741004523 active site 349741004524 metal binding site [ion binding]; metal-binding site 349741004525 interdomain interaction site; other site 349741004526 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 349741004527 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 349741004528 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 349741004529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349741004530 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 349741004531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 349741004532 DNA binding residues [nucleotide binding] 349741004533 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 349741004534 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 349741004535 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 349741004536 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 349741004537 dimer interface [polypeptide binding]; other site 349741004538 active site 349741004539 glycine-pyridoxal phosphate binding site [chemical binding]; other site 349741004540 folate binding site [chemical binding]; other site 349741004541 carboxy-terminal protease; Provisional; Region: PRK11186 349741004542 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 349741004543 protein binding site [polypeptide binding]; other site 349741004544 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 349741004545 Catalytic dyad [active] 349741004546 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 349741004547 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 349741004548 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 349741004549 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 349741004550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741004551 ATP binding site [chemical binding]; other site 349741004552 putative Mg++ binding site [ion binding]; other site 349741004553 nucleotide binding region [chemical binding]; other site 349741004554 helicase superfamily c-terminal domain; Region: HELICc; smart00490 349741004555 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 349741004556 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 349741004557 Phosphate transporter family; Region: PHO4; pfam01384 349741004558 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 349741004559 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741004560 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 349741004561 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 349741004562 active site 349741004563 NTP binding site [chemical binding]; other site 349741004564 metal binding triad [ion binding]; metal-binding site 349741004565 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 349741004566 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349741004567 Zn2+ binding site [ion binding]; other site 349741004568 Mg2+ binding site [ion binding]; other site 349741004569 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 349741004570 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 349741004571 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 349741004572 active site 349741004573 catalytic site [active] 349741004574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741004575 binding surface 349741004576 Tetratricopeptide repeat; Region: TPR_16; pfam13432 349741004577 TPR motif; other site 349741004578 Tetratricopeptide repeat; Region: TPR_16; pfam13432 349741004579 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 349741004580 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 349741004581 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 349741004582 putative acyl-acceptor binding pocket; other site 349741004583 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 349741004584 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 349741004585 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 349741004586 homodimer interface [polypeptide binding]; other site 349741004587 NADP binding site [chemical binding]; other site 349741004588 substrate binding site [chemical binding]; other site 349741004589 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 349741004590 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 349741004591 NAD binding site [chemical binding]; other site 349741004592 homotetramer interface [polypeptide binding]; other site 349741004593 homodimer interface [polypeptide binding]; other site 349741004594 substrate binding site [chemical binding]; other site 349741004595 active site 349741004596 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 349741004597 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 349741004598 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 349741004599 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 349741004600 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 349741004601 FMN binding site [chemical binding]; other site 349741004602 active site 349741004603 catalytic residues [active] 349741004604 substrate binding site [chemical binding]; other site 349741004605 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 349741004606 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 349741004607 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 349741004608 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 349741004609 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 349741004610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 349741004611 motif II; other site 349741004612 acetolactate synthase; Region: PLN02470 349741004613 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 349741004614 PYR/PP interface [polypeptide binding]; other site 349741004615 dimer interface [polypeptide binding]; other site 349741004616 TPP binding site [chemical binding]; other site 349741004617 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 349741004618 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 349741004619 TPP-binding site [chemical binding]; other site 349741004620 dimer interface [polypeptide binding]; other site 349741004621 Peptidase of plants and bacteria; Region: BSP; pfam04450 349741004622 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 349741004623 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 349741004624 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 349741004625 substrate binding site [chemical binding]; other site 349741004626 hexamer interface [polypeptide binding]; other site 349741004627 metal binding site [ion binding]; metal-binding site 349741004628 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 349741004629 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 349741004630 HIGH motif; other site 349741004631 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 349741004632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741004633 active site 349741004634 KMSKS motif; other site 349741004635 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 349741004636 tRNA binding surface [nucleotide binding]; other site 349741004637 Sulfatase; Region: Sulfatase; cl17466 349741004638 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741004639 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 349741004640 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 349741004641 active site 349741004642 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349741004643 dimer interface [polypeptide binding]; other site 349741004644 catalytic residues [active] 349741004645 substrate binding site [chemical binding]; other site 349741004646 arginine decarboxylase; Provisional; Region: PRK05354 349741004647 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 349741004648 dimer interface [polypeptide binding]; other site 349741004649 active site 349741004650 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349741004651 catalytic residues [active] 349741004652 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 349741004653 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 349741004654 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 349741004655 active site 349741004656 catalytic residues [active] 349741004657 DNA binding site [nucleotide binding] 349741004658 Int/Topo IB signature motif; other site 349741004659 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 349741004660 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 349741004661 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 349741004662 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 349741004663 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 349741004664 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 349741004665 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 349741004666 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 349741004667 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349741004668 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 349741004669 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 349741004670 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 349741004671 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741004672 sugar binding site [chemical binding]; other site 349741004673 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 349741004674 beta-D-glucuronidase; Provisional; Region: PRK10150 349741004675 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 349741004676 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 349741004677 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 349741004678 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741004679 sugar binding site [chemical binding]; other site 349741004680 recombination factor protein RarA; Reviewed; Region: PRK13342 349741004681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741004682 Walker A motif; other site 349741004683 ATP binding site [chemical binding]; other site 349741004684 Walker B motif; other site 349741004685 arginine finger; other site 349741004686 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 349741004687 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741004688 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741004689 active site 349741004690 6-phosphofructokinase; Provisional; Region: PRK14072 349741004691 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 349741004692 active site 349741004693 ADP/pyrophosphate binding site [chemical binding]; other site 349741004694 dimerization interface [polypeptide binding]; other site 349741004695 allosteric effector site; other site 349741004696 fructose-1,6-bisphosphate binding site; other site 349741004697 Domain of unknown function (DUF303); Region: DUF303; pfam03629 349741004698 Transcriptional regulators [Transcription]; Region: FadR; COG2186 349741004699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 349741004700 DNA-binding site [nucleotide binding]; DNA binding site 349741004701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 349741004702 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 349741004703 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349741004704 active site 349741004705 DNA binding site [nucleotide binding] 349741004706 Int/Topo IB signature motif; other site 349741004707 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 349741004708 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 349741004709 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 349741004710 homotrimer interface [polypeptide binding]; other site 349741004711 Walker A motif; other site 349741004712 GTP binding site [chemical binding]; other site 349741004713 Walker B motif; other site 349741004714 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 349741004715 cobalamin synthase; Reviewed; Region: cobS; PRK00235 349741004716 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 349741004717 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 349741004718 active site pocket [active] 349741004719 putative dimer interface [polypeptide binding]; other site 349741004720 putative cataytic base [active] 349741004721 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 349741004722 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 349741004723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741004724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004725 homodimer interface [polypeptide binding]; other site 349741004726 catalytic residue [active] 349741004727 cobyric acid synthase; Provisional; Region: PRK00784 349741004728 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349741004729 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349741004730 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 349741004731 catalytic triad [active] 349741004732 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 349741004733 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 349741004734 N-terminal plug; other site 349741004735 ligand-binding site [chemical binding]; other site 349741004736 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 349741004737 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 349741004738 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 349741004739 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 349741004740 sugar binding site [chemical binding]; other site 349741004741 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 349741004742 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 349741004743 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 349741004744 active site 349741004745 putative substrate binding pocket [chemical binding]; other site 349741004746 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 349741004747 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 349741004748 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 349741004749 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 349741004750 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 349741004751 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 349741004752 active site 349741004753 NTP binding site [chemical binding]; other site 349741004754 metal binding triad [ion binding]; metal-binding site 349741004755 antibiotic binding site [chemical binding]; other site 349741004756 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 349741004757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 349741004758 E3 interaction surface; other site 349741004759 lipoyl attachment site [posttranslational modification]; other site 349741004760 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 349741004761 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 349741004762 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 349741004763 TPP-binding site [chemical binding]; other site 349741004764 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 349741004765 dimer interface [polypeptide binding]; other site 349741004766 PYR/PP interface [polypeptide binding]; other site 349741004767 TPP binding site [chemical binding]; other site 349741004768 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 349741004769 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 349741004770 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 349741004771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 349741004772 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741004773 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 349741004774 Low molecular weight phosphatase family; Region: LMWPc; cd00115 349741004775 active site 349741004776 CHASE2 domain; Region: CHASE2; cl01732 349741004777 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 349741004778 Phosphotransferase enzyme family; Region: APH; pfam01636 349741004779 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 349741004780 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 349741004781 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004782 catalytic residue [active] 349741004783 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349741004784 MarR family; Region: MarR; pfam01047 349741004785 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 349741004786 Ferritin-like domain; Region: Ferritin; pfam00210 349741004787 ferroxidase diiron center [ion binding]; other site 349741004788 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 349741004789 homotrimer interaction site [polypeptide binding]; other site 349741004790 putative active site [active] 349741004791 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 349741004792 putative active site [active] 349741004793 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 349741004794 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 349741004795 DEAD-like helicases superfamily; Region: DEXDc; smart00487 349741004796 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741004797 ATP binding site [chemical binding]; other site 349741004798 putative Mg++ binding site [ion binding]; other site 349741004799 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741004800 nucleotide binding region [chemical binding]; other site 349741004801 ATP-binding site [chemical binding]; other site 349741004802 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 349741004803 HRDC domain; Region: HRDC; pfam00570 349741004804 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 349741004805 CoA binding domain; Region: CoA_binding; smart00881 349741004806 CoA-ligase; Region: Ligase_CoA; pfam00549 349741004807 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 349741004808 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 349741004809 CoA-ligase; Region: Ligase_CoA; pfam00549 349741004810 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 349741004811 histidinol dehydrogenase; Region: hisD; TIGR00069 349741004812 NAD binding site [chemical binding]; other site 349741004813 dimerization interface [polypeptide binding]; other site 349741004814 product binding site; other site 349741004815 substrate binding site [chemical binding]; other site 349741004816 zinc binding site [ion binding]; other site 349741004817 catalytic residues [active] 349741004818 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 349741004819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 349741004820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741004821 TPR motif; other site 349741004822 binding surface 349741004823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 349741004824 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 349741004825 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 349741004826 generic binding surface II; other site 349741004827 generic binding surface I; other site 349741004828 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 349741004829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 349741004830 acyl-activating enzyme (AAE) consensus motif; other site 349741004831 AMP binding site [chemical binding]; other site 349741004832 active site 349741004833 CoA binding site [chemical binding]; other site 349741004834 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741004835 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 349741004836 Autotransporter beta-domain; Region: Autotransporter; pfam03797 349741004837 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 349741004838 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 349741004839 active site 349741004840 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 349741004841 active site 2 [active] 349741004842 active site 1 [active] 349741004843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 349741004844 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 349741004845 NAD binding site [chemical binding]; other site 349741004846 putative substrate binding site 2 [chemical binding]; other site 349741004847 putative substrate binding site 1 [chemical binding]; other site 349741004848 active site 349741004849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 349741004850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 349741004851 dimer interface [polypeptide binding]; other site 349741004852 phosphorylation site [posttranslational modification] 349741004853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741004854 ATP binding site [chemical binding]; other site 349741004855 Mg2+ binding site [ion binding]; other site 349741004856 G-X-G motif; other site 349741004857 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 349741004858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 349741004859 active site 349741004860 phosphorylation site [posttranslational modification] 349741004861 intermolecular recognition site; other site 349741004862 dimerization interface [polypeptide binding]; other site 349741004863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 349741004864 DNA binding site [nucleotide binding] 349741004865 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 349741004866 dimer interface [polypeptide binding]; other site 349741004867 allosteric magnesium binding site [ion binding]; other site 349741004868 active site 349741004869 aspartate-rich active site metal binding site; other site 349741004870 Schiff base residues; other site 349741004871 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 349741004872 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 349741004873 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 349741004874 active site 349741004875 dimer interface [polypeptide binding]; other site 349741004876 motif 1; other site 349741004877 motif 2; other site 349741004878 motif 3; other site 349741004879 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 349741004880 anticodon binding site; other site 349741004881 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 349741004882 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 349741004883 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 349741004884 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 349741004885 Predicted membrane protein [Function unknown]; Region: COG2311 349741004886 Protein of unknown function (DUF418); Region: DUF418; pfam04235 349741004887 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 349741004888 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 349741004889 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 349741004890 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 349741004891 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 349741004892 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 349741004893 active site 349741004894 (T/H)XGH motif; other site 349741004895 RF-1 domain; Region: RF-1; pfam00472 349741004896 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 349741004897 active site 349741004898 substrate binding site; other site 349741004899 Methyltransferase domain; Region: Methyltransf_31; pfam13847 349741004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741004901 S-adenosylmethionine binding site [chemical binding]; other site 349741004902 Tetratricopeptide repeat; Region: TPR_6; pfam13174 349741004903 LicD family; Region: LicD; pfam04991 349741004904 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 349741004905 active site 349741004906 nucleotide binding site [chemical binding]; other site 349741004907 HIGH motif; other site 349741004908 KMSKS motif; other site 349741004909 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 349741004910 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349741004911 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 349741004912 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 349741004913 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 349741004914 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 349741004915 active site 349741004916 metal-binding site 349741004917 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 349741004918 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741004919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004920 homodimer interface [polypeptide binding]; other site 349741004921 catalytic residue [active] 349741004922 LicD family; Region: LicD; pfam04991 349741004923 1,4-alpha-glucan-branching enzyme; Region: PLN02447 349741004924 N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854 349741004925 Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321 349741004926 active site 349741004927 catalytic site [active] 349741004928 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 349741004929 PEGA domain; Region: PEGA; pfam08308 349741004930 Fe-S metabolism associated domain; Region: SufE; cl00951 349741004931 ornithine carbamoyltransferase; Provisional; Region: PRK00779 349741004932 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 349741004933 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 349741004934 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 349741004935 Sulfatase; Region: Sulfatase; pfam00884 349741004936 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 349741004937 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 349741004938 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 349741004939 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 349741004940 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 349741004941 dimerization domain swap beta strand [polypeptide binding]; other site 349741004942 regulatory protein interface [polypeptide binding]; other site 349741004943 active site 349741004944 regulatory phosphorylation site [posttranslational modification]; other site 349741004945 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 349741004946 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 349741004947 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 349741004948 Hpr binding site; other site 349741004949 active site 349741004950 homohexamer subunit interaction site [polypeptide binding]; other site 349741004951 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 349741004952 hypothetical protein; Provisional; Region: PRK08201 349741004953 metal binding site [ion binding]; metal-binding site 349741004954 putative dimer interface [polypeptide binding]; other site 349741004955 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 349741004956 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 349741004957 Walker A/P-loop; other site 349741004958 ATP binding site [chemical binding]; other site 349741004959 Q-loop/lid; other site 349741004960 ABC transporter signature motif; other site 349741004961 Walker B; other site 349741004962 D-loop; other site 349741004963 H-loop/switch region; other site 349741004964 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 349741004965 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 349741004966 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 349741004967 G1 box; other site 349741004968 GTP/Mg2+ binding site [chemical binding]; other site 349741004969 G2 box; other site 349741004970 Switch I region; other site 349741004971 G3 box; other site 349741004972 Switch II region; other site 349741004973 G4 box; other site 349741004974 G5 box; other site 349741004975 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 349741004976 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349741004977 catalytic residue [active] 349741004978 hypothetical protein; Validated; Region: PRK00228 349741004979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 349741004980 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741004981 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741004982 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 349741004983 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 349741004984 DXD motif; other site 349741004985 Protein of unknown function (DUF525); Region: DUF525; cl01119 349741004986 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 349741004987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741004988 ATP binding site [chemical binding]; other site 349741004989 putative Mg++ binding site [ion binding]; other site 349741004990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741004991 nucleotide binding region [chemical binding]; other site 349741004992 ATP-binding site [chemical binding]; other site 349741004993 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 349741004994 AsnC family; Region: AsnC_trans_reg; pfam01037 349741004995 hypothetical protein; Validated; Region: PRK07682 349741004996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741004997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741004998 homodimer interface [polypeptide binding]; other site 349741004999 catalytic residue [active] 349741005000 CAAX protease self-immunity; Region: Abi; cl00558 349741005001 Uncharacterized conserved protein [Function unknown]; Region: COG1434 349741005002 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 349741005003 putative active site [active] 349741005004 glycyl-tRNA synthetase; Provisional; Region: PRK04173 349741005005 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 349741005006 motif 1; other site 349741005007 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 349741005008 active site 349741005009 motif 2; other site 349741005010 motif 3; other site 349741005011 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 349741005012 anticodon binding site; other site 349741005013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741005014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741005015 active site 349741005016 catalytic tetrad [active] 349741005017 Oxygen tolerance; Region: BatD; pfam13584 349741005018 TPR repeat; Region: TPR_11; pfam13414 349741005019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741005020 binding surface 349741005021 TPR motif; other site 349741005022 von Willebrand factor type A domain; Region: VWA_2; pfam13519 349741005023 metal ion-dependent adhesion site (MIDAS); other site 349741005024 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 349741005025 metal ion-dependent adhesion site (MIDAS); other site 349741005026 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 349741005027 Protein of unknown function DUF58; Region: DUF58; pfam01882 349741005028 MoxR-like ATPases [General function prediction only]; Region: COG0714 349741005029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741005030 Walker A motif; other site 349741005031 ATP binding site [chemical binding]; other site 349741005032 Walker B motif; other site 349741005033 arginine finger; other site 349741005034 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 349741005035 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 349741005036 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 349741005037 TPR repeat; Region: TPR_11; pfam13414 349741005038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741005039 TPR motif; other site 349741005040 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 349741005041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349741005042 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 349741005043 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 349741005044 protein binding site [polypeptide binding]; other site 349741005045 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 349741005046 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 349741005047 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 349741005048 Catalytic site [active] 349741005049 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 349741005050 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 349741005051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741005052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741005053 homodimer interface [polypeptide binding]; other site 349741005054 catalytic residue [active] 349741005055 Domain of unknown function (DUF362); Region: DUF362; pfam04015 349741005056 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741005057 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741005058 active site 349741005059 catalytic tetrad [active] 349741005060 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 349741005061 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741005062 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741005063 active site 349741005064 catalytic tetrad [active] 349741005065 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 349741005066 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349741005067 putative active site [active] 349741005068 putative metal binding site [ion binding]; other site 349741005069 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 349741005070 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 349741005071 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 349741005072 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 349741005073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 349741005074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 349741005075 active site 349741005076 catalytic tetrad [active] 349741005077 Amidohydrolase; Region: Amidohydro_2; pfam04909 349741005078 active site 349741005079 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 349741005080 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 349741005081 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 349741005082 DNA binding residues [nucleotide binding] 349741005083 putative dimer interface [polypeptide binding]; other site 349741005084 Domain of unknown function (DUF386); Region: DUF386; cl01047 349741005085 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 349741005086 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 349741005087 active site 349741005088 Na/Ca binding site [ion binding]; other site 349741005089 catalytic site [active] 349741005090 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 349741005091 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 349741005092 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 349741005093 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741005094 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 349741005095 active site 349741005096 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 349741005097 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 349741005098 metal binding site [ion binding]; metal-binding site 349741005099 substrate binding pocket [chemical binding]; other site 349741005100 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 349741005101 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 349741005102 NADP binding site [chemical binding]; other site 349741005103 active site 349741005104 putative substrate binding site [chemical binding]; other site 349741005105 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 349741005106 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 349741005107 putative RNA binding site [nucleotide binding]; other site 349741005108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741005109 S-adenosylmethionine binding site [chemical binding]; other site 349741005110 hypothetical protein; Region: PHA00661 349741005111 hypothetical protein; Region: PHA00661 349741005112 KH domain; Region: KH_4; pfam13083 349741005113 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 349741005114 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 349741005115 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 349741005116 putative RNA binding site [nucleotide binding]; other site 349741005117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741005118 S-adenosylmethionine binding site [chemical binding]; other site 349741005119 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 349741005120 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 349741005121 active site 349741005122 trimer interface [polypeptide binding]; other site 349741005123 allosteric site; other site 349741005124 active site lid [active] 349741005125 hexamer (dimer of trimers) interface [polypeptide binding]; other site 349741005126 PA14 domain; Region: PA14; cl08459 349741005127 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 349741005128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 349741005129 RNA binding surface [nucleotide binding]; other site 349741005130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741005131 S-adenosylmethionine binding site [chemical binding]; other site 349741005132 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 349741005133 Pirin-related protein [General function prediction only]; Region: COG1741 349741005134 Pirin; Region: Pirin; pfam02678 349741005135 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 349741005136 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 349741005137 intersubunit interface [polypeptide binding]; other site 349741005138 active site 349741005139 Zn2+ binding site [ion binding]; other site 349741005140 L-fuculokinase; Provisional; Region: PRK10331 349741005141 L-fuculose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_FK; cd07773 349741005142 putative N- and C-terminal domain interface [polypeptide binding]; other site 349741005143 putative active site [active] 349741005144 putative MgATP binding site [chemical binding]; other site 349741005145 putative catalytic site [active] 349741005146 metal binding site [ion binding]; metal-binding site 349741005147 putative carbohydrate binding site [chemical binding]; other site 349741005148 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 349741005149 L-fucose isomerase; Provisional; Region: fucI; PRK10991 349741005150 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 349741005151 hexamer (dimer of trimers) interface [polypeptide binding]; other site 349741005152 trimer interface [polypeptide binding]; other site 349741005153 substrate binding site [chemical binding]; other site 349741005154 Mn binding site [ion binding]; other site 349741005155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 349741005156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741005157 putative substrate translocation pore; other site 349741005158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 349741005159 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 349741005160 catalytic site [active] 349741005161 BNR repeat-like domain; Region: BNR_2; pfam13088 349741005162 Asp-box motif; other site 349741005163 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 349741005164 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349741005165 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 349741005166 DNA binding residues [nucleotide binding] 349741005167 Uncharacterized family 3; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_3; cd10160 349741005168 putative homodimer interface [polypeptide binding]; other site 349741005169 putative homotetramer interface [polypeptide binding]; other site 349741005170 putative metal binding site [ion binding]; other site 349741005171 putative homodimer-homodimer interface [polypeptide binding]; other site 349741005172 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 349741005173 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 349741005174 Soluble P-type ATPase [General function prediction only]; Region: COG4087 349741005175 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 349741005176 ThiC-associated domain; Region: ThiC-associated; pfam13667 349741005177 ThiC family; Region: ThiC; cl08031 349741005178 ThiC family; Region: ThiC; pfam01964 349741005179 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 349741005180 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741005181 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 349741005182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 349741005183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 349741005184 DNA binding residues [nucleotide binding] 349741005185 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 349741005186 protein binding site [polypeptide binding]; other site 349741005187 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 349741005188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 349741005189 Zn2+ binding site [ion binding]; other site 349741005190 Mg2+ binding site [ion binding]; other site 349741005191 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 349741005192 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 349741005193 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 349741005194 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 349741005195 active site 349741005196 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349741005197 dimer interface [polypeptide binding]; other site 349741005198 substrate binding site [chemical binding]; other site 349741005199 catalytic residues [active] 349741005200 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 349741005201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 349741005202 Walker A/P-loop; other site 349741005203 ATP binding site [chemical binding]; other site 349741005204 Q-loop/lid; other site 349741005205 ABC transporter signature motif; other site 349741005206 Walker B; other site 349741005207 D-loop; other site 349741005208 H-loop/switch region; other site 349741005209 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 349741005210 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 349741005211 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 349741005212 Walker A/P-loop; other site 349741005213 ATP binding site [chemical binding]; other site 349741005214 Q-loop/lid; other site 349741005215 ABC transporter signature motif; other site 349741005216 Walker B; other site 349741005217 D-loop; other site 349741005218 H-loop/switch region; other site 349741005219 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 349741005220 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 349741005221 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 349741005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741005223 dimer interface [polypeptide binding]; other site 349741005224 conserved gate region; other site 349741005225 putative PBP binding loops; other site 349741005226 ABC-ATPase subunit interface; other site 349741005227 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 349741005228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 349741005229 dimer interface [polypeptide binding]; other site 349741005230 conserved gate region; other site 349741005231 putative PBP binding loops; other site 349741005232 ABC-ATPase subunit interface; other site 349741005233 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349741005234 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 349741005235 active site 349741005236 metal binding site [ion binding]; metal-binding site 349741005237 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 349741005238 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 349741005239 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 349741005240 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 349741005241 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 349741005242 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 349741005243 Potassium binding sites [ion binding]; other site 349741005244 Cesium cation binding sites [ion binding]; other site 349741005245 Domain of unknown function (DUF1287); Region: DUF1287; pfam06940 349741005246 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 349741005247 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 349741005248 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 349741005249 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 349741005250 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 349741005251 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 349741005252 dimer interface [polypeptide binding]; other site 349741005253 ssDNA binding site [nucleotide binding]; other site 349741005254 tetramer (dimer of dimers) interface [polypeptide binding]; other site 349741005255 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 349741005256 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 349741005257 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 349741005258 active site 349741005259 catalytic residues [active] 349741005260 metal binding site [ion binding]; metal-binding site 349741005261 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 349741005262 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 349741005263 putative active site [active] 349741005264 catalytic site [active] 349741005265 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 349741005266 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 349741005267 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 349741005268 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 349741005269 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 349741005270 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 349741005271 trimer interface [polypeptide binding]; other site 349741005272 active site 349741005273 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 349741005274 catalytic site [active] 349741005275 chorismate binding enzyme; Region: Chorismate_bind; cl10555 349741005276 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 349741005277 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 349741005278 Cytochrome c; Region: Cytochrom_C; pfam00034 349741005279 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 349741005280 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 349741005281 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 349741005282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 349741005283 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 349741005284 active site 349741005285 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 349741005286 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741005287 isocitrate dehydrogenase; Validated; Region: PRK07362 349741005288 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 349741005289 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 349741005290 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 349741005291 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 349741005292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 349741005293 Beta-Casp domain; Region: Beta-Casp; pfam10996 349741005294 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 349741005295 thymidylate kinase; Validated; Region: tmk; PRK00698 349741005296 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 349741005297 TMP-binding site; other site 349741005298 ATP-binding site [chemical binding]; other site 349741005299 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 349741005300 Ligand Binding Site [chemical binding]; other site 349741005301 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 349741005302 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 349741005303 Mechanosensitive ion channel; Region: MS_channel; pfam00924 349741005304 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 349741005305 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 349741005306 active site 349741005307 HIGH motif; other site 349741005308 KMSKS motif; other site 349741005309 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 349741005310 Bacitracin resistance protein BacA; Region: BacA; pfam02673 349741005311 Flagellin N-methylase; Region: FliB; cl00497 349741005312 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 349741005313 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 349741005314 hinge; other site 349741005315 active site 349741005316 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 349741005317 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 349741005318 hinge; other site 349741005319 active site 349741005320 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 349741005321 IHF - DNA interface [nucleotide binding]; other site 349741005322 IHF dimer interface [polypeptide binding]; other site 349741005323 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 349741005324 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 349741005325 Tetramer interface [polypeptide binding]; other site 349741005326 active site 349741005327 FMN-binding site [chemical binding]; other site 349741005328 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 349741005329 Pre-mRNA-splicing factor of RES complex; Region: Bud13; pfam09736 349741005330 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 349741005331 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 349741005332 putative active site [active] 349741005333 putative metal binding site [ion binding]; other site 349741005334 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 349741005335 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 349741005336 GGGtGRT protein; Region: GGGtGRT; pfam14057 349741005337 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 349741005338 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 349741005339 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349741005340 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 349741005341 active site 349741005342 DNA binding site [nucleotide binding] 349741005343 Int/Topo IB signature motif; other site 349741005344 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 349741005345 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 349741005346 putative active site [active] 349741005347 metal binding site [ion binding]; metal-binding site 349741005348 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 349741005349 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 349741005350 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 349741005351 ATP binding site [chemical binding]; other site 349741005352 putative Mg++ binding site [ion binding]; other site 349741005353 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 349741005354 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 349741005355 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 349741005356 HsdM N-terminal domain; Region: HsdM_N; pfam12161 349741005357 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 349741005358 Methyltransferase domain; Region: Methyltransf_26; pfam13659 349741005359 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 349741005360 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 349741005361 substrate binding site [chemical binding]; other site 349741005362 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 349741005363 ATP binding site [chemical binding]; other site 349741005364 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 349741005365 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 349741005366 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 349741005367 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 349741005368 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 349741005369 Substrate binding site; other site 349741005370 metal-binding site 349741005371 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 349741005372 Predicted periplasmic protein [Function unknown]; Region: COG3698 349741005373 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 349741005374 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 349741005375 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 349741005376 putative active site [active] 349741005377 catalytic triad [active] 349741005378 putative dimer interface [polypeptide binding]; other site 349741005379 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 349741005380 Protein of unknown function (DUF721); Region: DUF721; pfam05258 349741005381 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 349741005382 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741005383 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cd02742 349741005384 active site 349741005385 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741005386 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 349741005387 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 349741005388 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 349741005389 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 349741005390 putative ligand binding residues [chemical binding]; other site 349741005391 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 349741005392 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 349741005393 Walker A/P-loop; other site 349741005394 ATP binding site [chemical binding]; other site 349741005395 Q-loop/lid; other site 349741005396 ABC transporter signature motif; other site 349741005397 Walker B; other site 349741005398 D-loop; other site 349741005399 H-loop/switch region; other site 349741005400 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 349741005401 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 349741005402 ABC-ATPase subunit interface; other site 349741005403 dimer interface [polypeptide binding]; other site 349741005404 putative PBP binding regions; other site 349741005405 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 349741005406 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 349741005407 ABC-ATPase subunit interface; other site 349741005408 dimer interface [polypeptide binding]; other site 349741005409 putative PBP binding regions; other site 349741005410 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 349741005411 homotrimer interaction site [polypeptide binding]; other site 349741005412 putative active site [active] 349741005413 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 349741005414 homotrimer interaction site [polypeptide binding]; other site 349741005415 putative active site [active] 349741005416 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 349741005417 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 349741005418 Imelysin; Region: Peptidase_M75; pfam09375 349741005419 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 349741005420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 349741005421 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349741005422 active site 349741005423 DNA polymerase I; Provisional; Region: PRK05755 349741005424 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 349741005425 active site 349741005426 metal binding site 1 [ion binding]; metal-binding site 349741005427 putative 5' ssDNA interaction site; other site 349741005428 metal binding site 3; metal-binding site 349741005429 metal binding site 2 [ion binding]; metal-binding site 349741005430 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 349741005431 putative DNA binding site [nucleotide binding]; other site 349741005432 putative metal binding site [ion binding]; other site 349741005433 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 349741005434 active site 349741005435 catalytic site [active] 349741005436 substrate binding site [chemical binding]; other site 349741005437 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 349741005438 active site 349741005439 DNA binding site [nucleotide binding] 349741005440 catalytic site [active] 349741005441 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 349741005442 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 349741005443 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741005444 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 349741005445 adenylosuccinate lyase; Region: purB; TIGR00928 349741005446 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 349741005447 tetramer interface [polypeptide binding]; other site 349741005448 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 349741005449 peptidase T; Region: peptidase-T; TIGR01882 349741005450 metal binding site [ion binding]; metal-binding site 349741005451 dimer interface [polypeptide binding]; other site 349741005452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741005453 binding surface 349741005454 TPR repeat; Region: TPR_11; pfam13414 349741005455 TPR motif; other site 349741005456 TPR repeat; Region: TPR_11; pfam13414 349741005457 Tetratricopeptide repeat; Region: TPR_17; pfam13431 349741005458 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 349741005459 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 349741005460 NAD binding site [chemical binding]; other site 349741005461 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 349741005462 Class I aldolases; Region: Aldolase_Class_I; cl17187 349741005463 catalytic residue [active] 349741005464 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 349741005465 dimerization interface [polypeptide binding]; other site 349741005466 putative active cleft [active] 349741005467 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 349741005468 substrate-cofactor binding pocket; other site 349741005469 homodimer interface [polypeptide binding]; other site 349741005470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741005471 catalytic residue [active] 349741005472 para-aminobenzoate synthase component I; Validated; Region: PRK07093 349741005473 Glutamine amidotransferase class-I; Region: GATase; pfam00117 349741005474 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 349741005475 glutamine binding [chemical binding]; other site 349741005476 catalytic triad [active] 349741005477 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 349741005478 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 349741005479 putative active site [active] 349741005480 putative FMN binding site [chemical binding]; other site 349741005481 putative substrate binding site [chemical binding]; other site 349741005482 putative catalytic residue [active] 349741005483 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 349741005484 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 349741005485 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 349741005486 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 349741005487 catalytic triad [active] 349741005488 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 349741005489 putative deacylase active site [active] 349741005490 Predicted membrane protein [Function unknown]; Region: COG2364 349741005491 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 349741005492 PA14 domain; Region: PA14; cl08459 349741005493 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 349741005494 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 349741005495 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 349741005496 substrate binding pocket [chemical binding]; other site 349741005497 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 349741005498 B12 binding site [chemical binding]; other site 349741005499 cobalt ligand [ion binding]; other site 349741005500 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 349741005501 Uncharacterized conserved protein [Function unknown]; Region: COG2966 349741005502 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 349741005503 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 349741005504 homoserine dehydrogenase; Provisional; Region: PRK06349 349741005505 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 349741005506 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 349741005507 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 349741005508 aspartate kinase; Reviewed; Region: PRK06635 349741005509 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 349741005510 putative catalytic residues [active] 349741005511 putative nucleotide binding site [chemical binding]; other site 349741005512 putative aspartate binding site [chemical binding]; other site 349741005513 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 349741005514 putative allosteric regulatory site; other site 349741005515 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 349741005516 putative allosteric regulatory residue; other site 349741005517 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 349741005518 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 349741005519 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 349741005520 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 349741005521 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 349741005522 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 349741005523 TSCPD domain; Region: TSCPD; pfam12637 349741005524 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 349741005525 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 349741005526 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 349741005527 shikimate binding site; other site 349741005528 NAD(P) binding site [chemical binding]; other site 349741005529 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 349741005530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 349741005531 minor groove reading motif; other site 349741005532 helix-hairpin-helix signature motif; other site 349741005533 substrate binding pocket [chemical binding]; other site 349741005534 active site 349741005535 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349741005536 nudix motif; other site 349741005537 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 349741005538 pyruvate phosphate dikinase; Provisional; Region: PRK09279 349741005539 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 349741005540 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 349741005541 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 349741005542 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 349741005543 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 349741005544 active site 349741005545 dimer interface [polypeptide binding]; other site 349741005546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 349741005547 dimer interface [polypeptide binding]; other site 349741005548 active site 349741005549 TPR repeat; Region: TPR_11; pfam13414 349741005550 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741005551 Sel1-like repeats; Region: SEL1; smart00671 349741005552 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 349741005553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 349741005554 S-adenosylmethionine binding site [chemical binding]; other site 349741005555 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 349741005556 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 349741005557 active site 349741005558 substrate binding site [chemical binding]; other site 349741005559 coenzyme B12 binding site [chemical binding]; other site 349741005560 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 349741005561 B12 binding site [chemical binding]; other site 349741005562 cobalt ligand [ion binding]; other site 349741005563 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 349741005564 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 349741005565 heterodimer interface [polypeptide binding]; other site 349741005566 substrate interaction site [chemical binding]; other site 349741005567 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 349741005568 B12 binding site [chemical binding]; other site 349741005569 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 349741005570 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741005571 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 349741005572 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 349741005573 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 349741005574 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 349741005575 Protein of unknown function (DUF511); Region: DUF511; cl01114 349741005576 Protein kinase domain; Region: Pkinase; pfam00069 349741005577 Catalytic domain of Protein Kinases; Region: PKc; cd00180 349741005578 active site 349741005579 ATP binding site [chemical binding]; other site 349741005580 substrate binding site [chemical binding]; other site 349741005581 activation loop (A-loop); other site 349741005582 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 349741005583 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 349741005584 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 349741005585 catalytic residue [active] 349741005586 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 349741005587 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 349741005588 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 349741005589 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 349741005590 putative tRNA-binding site [nucleotide binding]; other site 349741005591 B3/4 domain; Region: B3_4; pfam03483 349741005592 tRNA synthetase B5 domain; Region: B5; smart00874 349741005593 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 349741005594 dimer interface [polypeptide binding]; other site 349741005595 motif 1; other site 349741005596 motif 3; other site 349741005597 motif 2; other site 349741005598 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 349741005599 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 349741005600 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 349741005601 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 349741005602 dimer interface [polypeptide binding]; other site 349741005603 motif 1; other site 349741005604 active site 349741005605 motif 2; other site 349741005606 motif 3; other site 349741005607 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 349741005608 Peptidase M60-like family; Region: M60-like; pfam13402 349741005609 heat shock protein 90; Provisional; Region: PRK05218 349741005610 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 349741005611 ATP binding site [chemical binding]; other site 349741005612 Mg2+ binding site [ion binding]; other site 349741005613 G-X-G motif; other site 349741005614 Ion transport protein; Region: Ion_trans; pfam00520 349741005615 Ion channel; Region: Ion_trans_2; pfam07885 349741005616 Protein of unknown function (DUF805); Region: DUF805; pfam05656 349741005617 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 349741005618 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 349741005619 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 349741005620 active site 349741005621 catalytic residues [active] 349741005622 DNA binding site [nucleotide binding] 349741005623 Int/Topo IB signature motif; other site 349741005624 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 349741005625 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 349741005626 HNH endonuclease; Region: HNH_4; pfam13395 349741005627 alanine racemase; Reviewed; Region: alr; PRK00053 349741005628 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 349741005629 active site 349741005630 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 349741005631 dimer interface [polypeptide binding]; other site 349741005632 substrate binding site [chemical binding]; other site 349741005633 catalytic residues [active] 349741005634 Transcriptional regulator; Region: Rrf2; cl17282 349741005635 Rrf2 family protein; Region: rrf2_super; TIGR00738 349741005636 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 349741005637 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 349741005638 homodimer interface [polypeptide binding]; other site 349741005639 substrate-cofactor binding pocket; other site 349741005640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741005641 catalytic residue [active] 349741005642 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 349741005643 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 349741005644 dimer interface [polypeptide binding]; other site 349741005645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741005646 catalytic residue [active] 349741005647 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 349741005648 thiamine phosphate binding site [chemical binding]; other site 349741005649 active site 349741005650 pyrophosphate binding site [ion binding]; other site 349741005651 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 349741005652 substrate binding site [chemical binding]; other site 349741005653 multimerization interface [polypeptide binding]; other site 349741005654 ATP binding site [chemical binding]; other site 349741005655 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 349741005656 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741005657 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741005658 active site 349741005659 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741005660 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741005661 active site 349741005662 membrane ATPase/protein kinase; Provisional; Region: PRK09435 349741005663 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 349741005664 Walker A; other site 349741005665 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 349741005666 nudix motif; other site 349741005667 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 349741005668 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 349741005669 active site 349741005670 putative DNA-binding cleft [nucleotide binding]; other site 349741005671 dimer interface [polypeptide binding]; other site 349741005672 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 349741005673 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 349741005674 ATP binding site [chemical binding]; other site 349741005675 Mg++ binding site [ion binding]; other site 349741005676 motif III; other site 349741005677 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 349741005678 nucleotide binding region [chemical binding]; other site 349741005679 ATP-binding site [chemical binding]; other site 349741005680 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 349741005681 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 349741005682 active site 349741005683 substrate binding pocket [chemical binding]; other site 349741005684 dimer interface [polypeptide binding]; other site 349741005685 MarR family; Region: MarR_2; pfam12802 349741005686 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 349741005687 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 349741005688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 349741005689 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741005690 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 349741005691 Protein export membrane protein; Region: SecD_SecF; cl14618 349741005692 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 349741005693 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 349741005694 folate binding site [chemical binding]; other site 349741005695 NADP+ binding site [chemical binding]; other site 349741005696 thymidylate synthase; Reviewed; Region: thyA; PRK01827 349741005697 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 349741005698 dimerization interface [polypeptide binding]; other site 349741005699 active site 349741005700 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 349741005701 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 349741005702 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 349741005703 putative active site [active] 349741005704 catalytic site [active] 349741005705 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 349741005706 putative active site [active] 349741005707 catalytic site [active] 349741005708 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 349741005709 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 349741005710 active site 349741005711 catalytic residues [active] 349741005712 metal binding site [ion binding]; metal-binding site 349741005713 homodimer binding site [polypeptide binding]; other site 349741005714 multidrug efflux protein; Reviewed; Region: PRK01766 349741005715 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 349741005716 cation binding site [ion binding]; other site 349741005717 antiporter inner membrane protein; Provisional; Region: PRK11670 349741005718 Domain of unknown function DUF59; Region: DUF59; cl00941 349741005719 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 349741005720 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; Region: PUR; smart00712 349741005721 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 349741005722 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 349741005723 active site 349741005724 catalytic residues [active] 349741005725 metal binding site [ion binding]; metal-binding site 349741005726 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 349741005727 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 349741005728 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 349741005729 active site 349741005730 Zn binding site [ion binding]; other site 349741005731 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 349741005732 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 349741005733 HlyD family secretion protein; Region: HlyD_3; pfam13437 349741005734 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 349741005735 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 349741005736 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 349741005737 active site 349741005738 catalytic triad [active] 349741005739 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 349741005740 K+ potassium transporter; Region: K_trans; cl15781 349741005741 YcxB-like protein; Region: YcxB; pfam14317 349741005742 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 349741005743 active site 349741005744 phosphorylation site [posttranslational modification] 349741005745 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 349741005746 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 349741005747 Cl- selectivity filter; other site 349741005748 Cl- binding residues [ion binding]; other site 349741005749 pore gating glutamate residue; other site 349741005750 dimer interface [polypeptide binding]; other site 349741005751 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 349741005752 Transposase IS200 like; Region: Y1_Tnp; cl00848 349741005753 glutamate dehydrogenase; Provisional; Region: PRK09414 349741005754 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 349741005755 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 349741005756 NAD(P) binding site [chemical binding]; other site 349741005757 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 349741005758 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 349741005759 Predicted membrane protein [Function unknown]; Region: COG1238 349741005760 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 349741005761 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 349741005762 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 349741005763 dinuclear metal binding motif [ion binding]; other site 349741005764 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 349741005765 dinuclear metal binding motif [ion binding]; other site 349741005766 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 349741005767 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741005768 hypothetical protein; Region: PHA00670 349741005769 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 349741005770 hypothetical protein; Region: PHA00662 349741005771 Transcriptional regulators [Transcription]; Region: MarR; COG1846 349741005772 Penicillinase repressor; Region: Pencillinase_R; cl17580 349741005773 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741005774 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 349741005775 Proline dehydrogenase; Region: Pro_dh; cl03282 349741005776 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 349741005777 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 349741005778 Glutamate binding site [chemical binding]; other site 349741005779 NAD binding site [chemical binding]; other site 349741005780 catalytic residues [active] 349741005781 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 349741005782 hydroperoxidase II; Provisional; Region: katE; PRK11249 349741005783 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 349741005784 tetramer interface [polypeptide binding]; other site 349741005785 heme binding pocket [chemical binding]; other site 349741005786 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 349741005787 domain interactions; other site 349741005788 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 349741005789 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 349741005790 Rubrerythrin [Energy production and conversion]; Region: COG1592 349741005791 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 349741005792 binuclear metal center [ion binding]; other site 349741005793 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 349741005794 iron binding site [ion binding]; other site 349741005795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 349741005796 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 349741005797 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 349741005798 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 349741005799 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 349741005800 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 349741005801 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 349741005802 SLBB domain; Region: SLBB; pfam10531 349741005803 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 349741005804 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 349741005805 AAA domain; Region: AAA_31; pfam13614 349741005806 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 349741005807 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 349741005808 Bacterial sugar transferase; Region: Bac_transf; pfam02397 349741005809 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349741005810 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 349741005811 metal-binding site 349741005812 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 349741005813 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741005814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741005815 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 349741005816 putative ADP-binding pocket [chemical binding]; other site 349741005817 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741005818 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 349741005819 putative ADP-binding pocket [chemical binding]; other site 349741005820 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 349741005821 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 349741005822 Protein of unknown function (DUF817); Region: DUF817; cl01520 349741005823 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 349741005824 GDP-Fucose binding site [chemical binding]; other site 349741005825 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741005826 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 349741005827 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 349741005828 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741005829 putative ADP-binding pocket [chemical binding]; other site 349741005830 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 349741005831 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 349741005832 putative ADP-binding pocket [chemical binding]; other site 349741005833 putative acyl transferase; Provisional; Region: PRK10502 349741005834 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 349741005835 putative trimer interface [polypeptide binding]; other site 349741005836 putative active site [active] 349741005837 putative substrate binding site [chemical binding]; other site 349741005838 putative CoA binding site [chemical binding]; other site 349741005839 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 349741005840 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 349741005841 putative metal binding site; other site 349741005842 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 349741005843 active site 349741005844 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 349741005845 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 349741005846 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 349741005847 Nitroreductase family; Region: Nitroreductase; pfam00881 349741005848 FMN binding site [chemical binding]; other site 349741005849 dimer interface [polypeptide binding]; other site 349741005850 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741005851 Phosphotransferase enzyme family; Region: APH; pfam01636 349741005852 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 349741005853 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 349741005854 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 349741005855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741005856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741005857 homodimer interface [polypeptide binding]; other site 349741005858 catalytic residue [active] 349741005859 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 349741005860 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 349741005861 active site 349741005862 HIGH motif; other site 349741005863 KMSKS motif; other site 349741005864 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 349741005865 tRNA binding surface [nucleotide binding]; other site 349741005866 anticodon binding site; other site 349741005867 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 349741005868 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 349741005869 PYR/PP interface [polypeptide binding]; other site 349741005870 dimer interface [polypeptide binding]; other site 349741005871 TPP binding site [chemical binding]; other site 349741005872 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 349741005873 TPP-binding site [chemical binding]; other site 349741005874 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 349741005875 Malic enzyme, N-terminal domain; Region: malic; pfam00390 349741005876 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 349741005877 putative NAD(P) binding site [chemical binding]; other site 349741005878 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 349741005879 NPCBM/NEW2 domain; Region: NPCBM; cl07060 349741005880 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 349741005881 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 349741005882 active site 349741005883 catalytic residues [active] 349741005884 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 349741005885 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 349741005886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 349741005887 active site 349741005888 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 349741005889 coproporphyrinogen III oxidase; Validated; Region: PRK05628 349741005890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 349741005891 FeS/SAM binding site; other site 349741005892 HemN C-terminal domain; Region: HemN_C; pfam06969 349741005893 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 349741005894 seryl-tRNA synthetase; Provisional; Region: PRK05431 349741005895 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 349741005896 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 349741005897 dimer interface [polypeptide binding]; other site 349741005898 active site 349741005899 motif 1; other site 349741005900 motif 2; other site 349741005901 motif 3; other site 349741005902 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 349741005903 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 349741005904 catalytic Zn binding site [ion binding]; other site 349741005905 structural Zn binding site [ion binding]; other site 349741005906 tetramer interface [polypeptide binding]; other site 349741005907 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 349741005908 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 349741005909 putative active site; other site 349741005910 catalytic triad [active] 349741005911 putative dimer interface [polypeptide binding]; other site 349741005912 MoxR-like ATPases [General function prediction only]; Region: COG0714 349741005913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 349741005914 Walker A motif; other site 349741005915 ATP binding site [chemical binding]; other site 349741005916 Walker B motif; other site 349741005917 arginine finger; other site 349741005918 Protein of unknown function DUF58; Region: DUF58; pfam01882 349741005919 von Willebrand factor type A domain; Region: VWA_2; pfam13519 349741005920 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 349741005921 putative active site [active] 349741005922 catalytic residue [active] 349741005923 Transglycosylase; Region: Transgly; pfam00912 349741005924 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 349741005925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 349741005926 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 349741005927 Switch II region; other site 349741005928 G4 box; other site 349741005929 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 349741005930 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 349741005931 GDP-binding site [chemical binding]; other site 349741005932 ACT binding site; other site 349741005933 IMP binding site; other site 349741005934 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 349741005935 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 349741005936 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 349741005937 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 349741005938 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 349741005939 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 349741005940 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 349741005941 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 349741005942 putative substrate-binding site; other site 349741005943 nickel binding site [ion binding]; other site 349741005944 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 349741005945 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 349741005946 Tic20-like protein; Region: Tic20; pfam09685 349741005947 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 349741005948 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 349741005949 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741005950 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 349741005951 active site 349741005952 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 349741005953 dimer interface [polypeptide binding]; other site 349741005954 FMN binding site [chemical binding]; other site 349741005955 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 349741005956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 349741005957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 349741005958 homodimer interface [polypeptide binding]; other site 349741005959 catalytic residue [active] 349741005960 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 349741005961 Acyltransferase family; Region: Acyl_transf_3; pfam01757 349741005962 Inner membrane protein CreD; Region: CreD; cl01844 349741005963 fumarate hydratase; Provisional; Region: PRK15389 349741005964 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 349741005965 Fumarase C-terminus; Region: Fumerase_C; pfam05683 349741005966 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 349741005967 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 349741005968 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 349741005969 active site 349741005970 signal recognition particle protein; Provisional; Region: PRK10867 349741005971 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 349741005972 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 349741005973 P loop; other site 349741005974 GTP binding site [chemical binding]; other site 349741005975 Signal peptide binding domain; Region: SRP_SPB; pfam02978 349741005976 Quinolinate synthetase A protein; Region: NadA; pfam02445 349741005977 Uncharacterized conserved protein [Function unknown]; Region: COG1565 349741005978 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 349741005979 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741005980 RHS Repeat; Region: RHS_repeat; pfam05593 349741005981 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 349741005982 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 349741005983 NADH dehydrogenase subunit B; Provisional; Region: PRK14815 349741005984 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 349741005985 conjugal transfer protein TraD; Provisional; Region: PRK13700 349741005986 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 349741005987 dimerization interface [polypeptide binding]; other site 349741005988 active site 349741005989 metal binding site [ion binding]; metal-binding site 349741005990 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 349741005991 acyl-activating enzyme (AAE) consensus motif; other site 349741005992 AMP binding site [chemical binding]; other site 349741005993 active site 349741005994 CoA binding site [chemical binding]; other site 349741005995 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741005996 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 349741005997 Sel1-like repeats; Region: SEL1; smart00671 349741005998 Sel1-like repeats; Region: SEL1; smart00671 349741005999 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 349741006000 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 349741006001 Glyco_18 domain; Region: Glyco_18; smart00636 349741006002 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 349741006003 active site 349741006004 Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004 349741006005 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 349741006006 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 349741006007 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 349741006008 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 349741006009 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 349741006010 active site 349741006011 Zn binding site [ion binding]; other site 349741006012 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 349741006013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 349741006014 TPR motif; other site 349741006015 binding surface 349741006016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 349741006017 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 349741006018 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 349741006019 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 349741006020 active site 349741006021 HIGH motif; other site 349741006022 KMSK motif region; other site 349741006023 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 349741006024 tRNA binding surface [nucleotide binding]; other site 349741006025 anticodon binding site; other site 349741006026 DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; Region: RPB9; COG1594 349741006027 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 349741006028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741006029 Coenzyme A binding pocket [chemical binding]; other site 349741006030 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 349741006031 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 349741006032 catalytic residues [active] 349741006033 TfoX N-terminal domain; Region: TfoX_N; pfam04993 349741006034 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 349741006035 AAA domain; Region: AAA_33; pfam13671 349741006036 P-loop motif; other site 349741006037 ATP binding site [chemical binding]; other site 349741006038 Chloramphenicol (Cm) binding site [chemical binding]; other site 349741006039 catalytic residue [active] 349741006040 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 349741006041 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349741006042 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349741006043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741006044 Walker A/P-loop; other site 349741006045 ATP binding site [chemical binding]; other site 349741006046 Q-loop/lid; other site 349741006047 ABC transporter signature motif; other site 349741006048 Walker B; other site 349741006049 D-loop; other site 349741006050 H-loop/switch region; other site 349741006051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741006052 Walker A/P-loop; other site 349741006053 ATP binding site [chemical binding]; other site 349741006054 Q-loop/lid; other site 349741006055 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 349741006056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 349741006057 AAA domain; Region: AAA_21; pfam13304 349741006058 Walker A/P-loop; other site 349741006059 ATP binding site [chemical binding]; other site 349741006060 Q-loop/lid; other site 349741006061 ABC transporter signature motif; other site 349741006062 Walker B; other site 349741006063 D-loop; other site 349741006064 H-loop/switch region; other site 349741006065 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 349741006066 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 349741006067 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 349741006068 nucleotide binding region [chemical binding]; other site 349741006069 ATP-binding site [chemical binding]; other site 349741006070 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 349741006071 nucleotide binding site [chemical binding]; other site 349741006072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 349741006073 Coenzyme A binding pocket [chemical binding]; other site